State Road 68 begins in New Harmony at State Road 69 and runs east, passing through the towns of Poseyville, Cynthiana, Haubstadt, Lynnville and Selvin.
The route of State Road 68 starts in New Harmony, intersecting with State Road 69. It then proceeds eastward, traversing the communities of Poseyville, Cynthiana, Haubstadt, Lynnville, and Selvin.