It was originally isolated from the mammalian small intestine amongst mammalian neurons called intramural neurons which function in the motor activity of the intestinal walls. An example of this was revealed in a study that demonstrated that this peptide regulates water and electrolyte transportation in the human jejunum; similar to its inhibitory effects on fluid absorption in the small intestine of pigs and rats.
This peptide was originally found in mammalian small intestine, alongside intramural neurons involved in intestinal wall motor activity. An example is provided by a study that demonstrated this peptide regulates water and electrolyte transport in human jejunum; similar to its inhibitory effect on fluid absorption in the intestines of pigs and rats.