He also found that application of serotonin (5-HT) produces an increase in the frequency and amplitude of spontaneous excitatory postsynaptic potentials in layer V pyramidal cells of the neocortex and transitional cortex by whole-cell recording in rat brain slices.
Serotonin (5-HT) application, when applied to rat brain slices, was found to increase the frequency and strength of spontaneous excitatory signals in layer V pyramidal cells of the neocortex and transitional cortex as measured by whole-cell recordings.