It is produced by typical esterification procedures with usual catalysts such as HCl or H2SO4, and is rather slow, usually done for 20+hr at 100°C or a bit higher. Validol, the anxiety medication containing a roughly 25% solution of menthol in menthyl isovalerate is prepared essentially in one step, in which the amount of menthol added before conducting the acid catalysed esterification is in an excess such that the resulting solution of the yielded ester has around 25% menthol, simplifying the procedure.
The compound's production involves typical esterification procedures and requires a long time (over 20 hours) at high temperatures (100°C or higher).  A simplified method for preparing Validol, an anxiety medication containing menthol in menthyl isovalerate, involves adding excess menthol before the acid-catalyzed esterification step. This results in a solution with around 25% menthol.