Furthermore, it was shown that p18INK4c is preferentially inhibitory to CDK6, but not CDK4 activity in activated T cells that suggest p18INK4c may set an inhibitory threshold in resting T cells.
Moreover, research revealed that p18INK4c has a greater inhibitory effect on CDK6 than CDK4 in activated T cells, suggesting that p18INK4c establishes a limiting condition in quiescent T cells.