Makharadze started his career as a low-ranking member of the Soviet Foreign Ministry, initially starting as a Clerk in the Soviet Embassy in Bulgaria in 1982. He was later posted in a Soviet Consulate in Calcutta, India.
Makharadze's early career path within the Soviet Foreign Ministry involved him starting as a low-ranking employee, first as a clerk at the Soviet Embassy in Bulgaria in 1982.  He then moved on to work at a Soviet Consulate in Calcutta, India.