In general, receptors for the series 2 prostanoids also bind with and respond to the series 1 and 3 prostanoids. Typically, prostanoid receptors show somewhat less affinity and responsiveness to the 1 and 3 series prostanoids.
Generally, receptors for the series 2 prostanoids can connect to and respond to the series 1 and 3 prostanoids. Prostanoid receptors usually have a diminished ability to bind with and react to the 1 and 3 series prostanoids.