An important observation is that in behavioral studies, rodents would consistently self-administer selective norepinephrine and dopamine releasing agents such as d-amphetamine, yet compounds that also release serotonin like naphthylisopropylamine would not be self-administered.
It's noteworthy to observe that in behavioral research, rats would repeatedly administer themselves certain norepinephrine and dopamine-releasing substances, such as d-amphetamine, but they wouldn't self-administer compounds that also release serotonin, like naphthylisopropylamine.