At the height of the 2001 EDSA Revolution, Reyes withdrew his support for Estrada, which led to the installation of Vice President Gloria Macapagal Arroyo as president, under whom he then served as Cabinet Secretary until 2010.
During the height of the 2001 EDSA Revolution, Reyes abandoned his support for Estrada, resulting in the appointment of Vice President Gloria Macapagal Arroyo as president, and he subsequently served as Cabinet Secretary until 2010 under her leadership.