In tissues with high energetic demands, oxygen is rapidly consumed, which increases the concentration of H+ and carbon dioxide. Through the Bohr effect, hemoglobin is induced to release more oxygen to supply cells that need it. In contrast, 2,3-BPG has no effect on the related compound myoglobin.
In tissues where energy demands are high, oxygen is consumed quickly, increasing the levels of H+ and carbon dioxide. The Bohr effect causes hemoglobin to release more oxygen for cells that need it. In contrast, 2,3-BPG does not influence the related compound myoglobin.