In Powellville, MD 354 intersects the western terminus of MD 374 (Burbage Crossing Road) at an acute angle and the eastern terminus of MD 350 (Mount Hermon Road) at a right angle before crossing Adkins Mill Pond. After passing through more farmland, the state highway enters the town of Willards and intersects U.S. Route 50 (US 50, Ocean Gateway).
In Powellville, MD 354 meets the western endpoint of MD 374 (Burbage Crossing Road) at a sharp angle and the eastern endpoint of MD 350 (Mount Hermon Road) at a right angle before crossing Adkins Mill Pond. Following through more agricultural areas, the state highway enters the town of Willards and intersects U.S. Route 50 (US 50, Ocean Gateway).