W90 in loop D is critical for ligand binding and antagonists may directly contact R92. The azabicyclic ring of the competitive antagonist granisetron is located close to W183 forming a cation-pi interaction. Loop E residues Y143, G148, E149, V150, Q151, N152, Y153 and K154 may be important for granisetron binding.
W90 in loop D is crucial for ligand attachment and antagonists may make direct contact with R92. The azabicyclic ring of the competitive antagonist granisetron is situated near W183, forming a cation-pi interaction. Loop E residues Y143, G148, E149, V150, Q151, N152, Y153, and K154 might play a significant role in granisetron binding.