Homospermidine synthase (HSS) catalyses the synthesis of the polyamine homospermidine from 2 mol putrescine in an NAD+-dependent reaction.
In cellular metabolism, homospermidine synthase (HSS) plays a crucial role in producing the polyamine compound homospermidine from 2 moles of putrescine through an NAD+-dependent reaction, which is analogous to other biochemical pathways involving nucleotide cofactors.