"Neuron specific" mouse Thy-1 promoter has been used to drive "brain specific" forced expression of proteins e.g. mutated Amyloid precursor protein(APP) as transgenic animal models of Alzheimer's disease. Thy-1 expression in the brain is developmentally regulated.
The study utilizes a mouse model where the Thy-1 promoter drives the expression of specific proteins like mutated APP in the brain. This expression is controlled by developmental stages, making it a valuable tool for studying Alzheimer's disease.