These AIF-deficient mouse models are important for fixing complex I deficiencies. The identification of AIF-interacting proteins in the inner mitochondrial membrane and intermembrane space will help researchers identify the mechanism of the signalling pathway that monitors the function of AIF in the mitochondria.
AIF-deficient mouse models are essential tools for investigating the mechanisms of complex I deficiencies, particularly in relation to the signaling pathways that regulate AIF activity within the mitochondria.