Lake Miccosukee was a natural prairie lake prior to the settlement by Miccosukee Indians the original indigenous inhabitants of Florida. Thousands of years ago, the lake connected directly with the St. Marks River on the south end.
Before the Miccosukee Indians established their presence in Florida, Lake Miccosukee existed as a natural prairie lake. Over millennia, it shared a direct connection with the St. Marks River at its southernmost point.