The following season, he marries Jo for a second time and helps save Meredith from losing her medical license. Midway through season 16, he disappeared to Iowa to see his mom, but it was revealed in the episode "Leave a Light On", Alex reconnected with Izzie, in the weeks leading up to Meredith's trial seeking her medical license to be reinstated. It was during that process that he chose to reach out to Izzie because he wanted to know if she was alive, okay, and willing to be there in person for Meredith's trial.
In the subsequent season, Alex marries Jo for a second time and assists Meredith in avoiding losing her medical license. He subsequently travels to Iowa to see his mother, but later reconnects with Izzie as Meredith prepares for her medical license reinstatement trial.