As a member of the BCL2 protein family, BAK1 functions as a pro-apoptotic regulator involved in a wide variety of cellular activities. In healthy mammalian cells, BAK1 localizes primarily to the MOM, but remains in an inactive form until stimulated by apoptotic signaling.
As a part of the BCL2 protein family, BAK1 acts as a pro-apoptotic controller participating in numerous cellular processes. In normal mammalian cells, BAK1 mainly resides at the mitochondria outer membrane (MOM), but remains in an inactive state until triggered by apoptotic signals.