As a post-translational modification, MYCN binding to C-terminal domains of tetrameric p53 impacts p53 promoter selectivity and interferes other cofactors binding to this region.
MYCN's post-translational modification of the p53 protein, which occurs by binding to its C-terminal domain within a tetrameric structure, alters p53's ability to regulate gene expression. This interaction specifically impacts promoter selectivity and hinders other cofactors from binding to this region.