In 1865, Comstock married Cornelia Guild Davis, the daughter of Daniel Guild, one of the pioneers of the Grand River Valley. They had two daughters, Etta (Mrs. Lucius Boltwood) and Clara (Mrs. Huntley Russell) (1866–1935).
In 1865, Comstock's marriage to Cornelia Guild Davis marked an important milestone, as she was the daughter of Daniel Guild, a key figure in the development of the Grand River Valley. This union would eventually produce two daughters, Etta and Clara.