At one point the CIA even sought the help of the Mafia in the hope they would be able to succeed where so many others had failed. Other characters are Cuban exile Félix Rodríguez, the CIA operative who trained Cuban exiles for the Bay of Pigs Invasion, and who was present when the Bolivian Army killed Che Guevara in 1967 at the request of the Bolivian President at the time, and Enrique Ovares, possibly the first man to make an attempt on Castro's life after he took power. Robert Maheu is also interviewed, the Hughes associate who served as liaison between the CIA and mobsters "Johnny" Roselli and Sam "Momo" Giancana, in another plot to kill Castro, this time using poison pills.
The CIA's attempts to assassinate Fidel Castro are highlighted, with various individuals involved, including Félix Rodríguez, Enrique Ovares, Robert Maheu, and the mobsters Johnny Roselli and Sam "Momo" Giancana.