NY 220 passes into the town of McDonough and enters a hamlet bearing the same name, where it turns eastward. The route winds its way through the eastern, forested portion of the town to the small community of East McDonough, located near the McDonough–Preston town line.
NY 220 moves into the town of McDonough and enters a hamlet with the same name, where it shifts eastward. The route meanders through the eastern, wooded part of the town to the small community of East McDonough, situated near the McDonough–Preston town boundary.