At this point, PA 72 merges onto westbound US 322 and the two routes head north-northwest along a four-lane freeway, reaching an interchange with the southern terminus of PA 117. The road passes over the Lebanon Valley Rail Trail at this interchange.
At this point, PA 72 joins westbound US 322, and the two routes travel north-northwest along a four-lane freeway, reaching an interchange with the southern terminus of PA 117. The road crosses over the Lebanon Valley Rail Trail at this intersection.