2-AG was discovered by Raphael Mechoulam and his student Shimon Ben-Shabat. 2-AG was a known chemical compound but its occurrence in mammals and its affinity for the cannabinoid receptors were first described in 1994–1995.
Raphael Mechoulam and his student Shimon Ben-Shabat discovered 2-AG. Although it had been previously known as a chemical compound, its occurrence in mammals and its interaction with cannabinoid receptors were initially described between 1994 and 1995.