While previously cases universally required heart transplantation, recent studies show that two-thirds of patients can survive past one year with high doses of immunosuppressants such as prednisone and cyclosporine. The transplanted heart has a high chance of disease recurrence. Compared to lymphocytic (presumed viral) myocarditis, giant cell myocarditis is much more severe with much more rapid progression.
In the past, all patients undergoing heart transplantation were required; however, recent studies indicate that two-thirds can survive beyond one year using high doses of immunosuppressive medications like prednisone and cyclosporine. The transplanted heart is susceptible to disease recurrence. Notably, giant cell myocarditis is more severe and progresses rapidly compared to lymphocytic (viral) myocarditis.