Belatacept, sold under the brand name Nulojix, is a fusion protein composed of the Fc fragment of a human IgG1 immunoglobulin linked to the extracellular domain of CTLA-4, which is a molecule crucial in the regulation of T cell costimulation, selectively blocking the process of T-cell activation.
Belatacept, marketed under Nulojix, is a fusion protein incorporating the Fc fragment of a human antibody with the extracellular domain of CTLA-4. CTLA-4 regulates T cell stimulation and selectively blocks T-cell activation.