The minimum effective oral dose to change serum osteocalcin levels is 1500 μg/d, where as oral MK-7 is effective on this parameter at 45 μg/d, a level more in line with nutritional intake.
To alter serum osteocalcin levels, an oral dose of 1500 μg/d is necessary. In contrast, oral MK-7 becomes effective at a lower dose of 45 μg/d for this parameter, which better reflects typical nutritional intake.