At the dose that can reduce cocaine intake, most of the analogs require a high DAT occupancy. This would mean that the agonists would need to be behaviorally active at the dose that can bring about reductions in cocaine craving. Most of the analogs will readily substitute for cocaine, although most do not elicit as many lever responses per session because of pharmacokinetic factors.
At the dose that can decrease cocaine consumption, most of the analogs need a high DAT occupancy. This would imply that agonists must be behaviorally active at the dose that could reduce cocaine cravings. Most of the analogs will easily replace cocaine, although many do not produce as many lever responses per session due to pharmacokinetic factors.