The changes in the ecology of the gingival sulcus impacts gene expression and changes the competitiveness of periodontal pathogens like Porphyromonas gingivalis. Hence, the growth of proteolytic and Gram-Negative Anaerobes (most of the time) will be favoured by fluctuating homeostasis, the natural balance, of the subgingival microflora.
Alterations in the gingival sulcus ecology affect gene expression and impact the dominance of periodontal pathogens such as Porphyromonas gingivalis. Consequently, proteolytic and Gram-Negative anaerobes (often) benefit from fluctuating homeostasis within subgingival microflora.