They supplied designs to the department stores Biki and later, La Rinascente in Milan, where in 1958, the first Missoni-labelled garments, a line of colourful vertically striped shirtdresses, were displayed in the window. Ottavio's experience as an activewear designer and manufacturer was applied to his and Rosita's designs, which contributed significantly to the development of Italian sportswear as a challenge to the American industry.
They designed for department stores Biki and La Rinascente in Milan. In 1958, they presented the first Missoni garments – colorful vertically striped shirtdresses – in store windows. Ottavio's background in activewear design was incorporated into their creations, which helped to elevate Italian sportswear as a counterpoint to American industry.