Pseudoproline dipeptides have proven particularly effective in the synthesis of intractable peptides, long peptides/small proteins, and cyclic peptides, enabling in many cases the production of peptides that otherwise could not be made. These dipeptides are extremely easy to use: simply substitute a serine or threonine residue together with the preceding amino acid residue in the peptide sequence with the appropriate pseudoproline dipeptide (see the figure on your right).
Pseudoproline dipeptides have proven effective for synthesizing difficult peptides, long peptides/small proteins, and cyclic peptides. They are extremely easy to use: replace a serine or threonine residue with its preceding amino acid in the peptide sequence with the appropriate pseudoproline dipeptide (see the figure on your right).