Enzymatic activity excising 8-oxoguanine from DNA (OGG activity) was reduced in peripheral blood mononuclear cells (PBMCs), and in paired lung tissue, from patients with non–small cell lung cancer.
There was a reduction in the enzymatic capacity to remove 8-oxoguanine from DNA (OGG activity) within peripheral blood mononuclear cells (PBMCs) as well as in corresponding lung tissue samples from individuals diagnosed with non–small cell lung cancer.