There are typically four vertebrate MRF paralogues which are homologous to typically a single MRF gene in non-vertebrates. These four genes are thought to have been duplicated in the two rounds of whole-genome duplication early in vertebrate evolution that played a role in the evolution of more complex vertebrate body plans.
Four vertebrate MRF paralogues exist, corresponding to a single MRF gene in non-vertebrates. These genes are thought to have been duplicated twice during the initial rounds of whole-genome duplication that occurred early in vertebrate evolution and played a role in creating more complex body plans for vertebrates.