Situated on the important Vilnius–Hrodna road, the village had a royal estate for accommodation of traveling Grand Dukes and other Lithuanian nobles. After Christianization of Lithuania, the village was one of the first places to construct a Catholic church funded by Vytautas the Great. In 1710, during the Great Northern War, the plague wiped out almost all inhabitants of Perloja.
The village, located on the significant Vilnius–Hrodna highway, had a royal estate for accommodating visiting Grand Dukes and Lithuanian nobles. Following Lithuania's Christianization, it was one of the first places to build a Catholic church funded by Vytautas the Great. In 1710, during the Great Northern War, the plague nearly wiped out almost all inhabitants of Perloja.