Demetrios Pepagomenos is lampooned in a 15th-century satire, Mazaris' Journey to Hades, as a doctor who poisoned himself. Mazaris says he had two sons: the older, Saromates ("Lizard Eyes"), also a doctor, and Theodosios the Little Stinker, a social climber. When Emperor Manuel II Palaeologos (r. 1391–1425) visited the Morea in 1415, Pepagomenos was a doctor in his retinue.
Demetrios Pepagomenos is ridiculed in a 15th-century satire, Mazaris' Journey to Hades, as a doctor who poisoned himself. Mazaris mentions he had two sons: the elder, Saromates ("Lizard Eyes"), also a doctor, and Theodosios the Little Stinker, a social climber. When Emperor Manuel II Palaeologos (r. 1391–1425) visited the Morea in 1415, Pepagomenos was a physician in his entourage.