A descendant of Marranos from around the city of Celorico, in the province of Beira, Portugal, he studied medicine at the University of Salamanca together with his older brother Fernando Isaac, and while the latter was given to his studies, Michael spent his time in singing serenades under ladies' balconies. After having completed his education, he left Spain for Venice.
From Celorico, a city in Beira province, Portugal, this Marrano descendant studied medicine at the University of Salamanca with his older brother Fernando Isaac. While the latter was engrossed in studies, Michael spent time serenading ladies from balconies. After finishing his education, he moved to Venice.