Nevertheless, since the CD-loop is quite flexible, the monomeric and polymerigenic forms are fully interconvertible, and one state can be favored over the other by altering the redox environment of the protein. Polymerization of PAI-2 occurs spontaneously under physiological conditions, for instance in the cytosol of placental cells.
Despite its flexibility, the CD-loop is adaptable, allowing for conversion between monomeric and polymerigenic forms. The preference of one form over the other can be influenced by altering the redox environment of the protein. Polymerization of PAI-2 occurs naturally under physiological conditions, such as in the cytosol of placental cells.