Most important economy branches are production of metallurgy products and the pharmaceutical industry. Its administrative seat is the town of Hlohovec. District is important for its transport location, Leopoldov is a railway hub and a D1 motorway connects the district area to Trnava, Bratislava and other Slovak regions.
Key economic activities include metallurgy products manufacturing and pharmaceuticals. The administrative headquarters is in Hlohovec town. The region's importance stems from its strategic transportation position; Leopoldov functions as a railway hub, while the D1 motorway connects the district to Trnava, Bratislava, and other Slovak areas.