Ishiwata's research interests go beyond the mechanical and physiological import of SPOC to bio-motile systems focusing on the structural and functional hierarchy from single molecules (myosin, kinesin, actin) to macromolecular assemblies (myofibrils, meiotic spindle and cells (cardiac, HeLa, etc.).
Ishiwata's research focuses on the intricate organization of SPOC within bio-motile systems. It examines its structural and functional relationships from the smallest components like individual proteins to larger structures such as myofibrils, meiotic spindles, and various cell types.