CXCR2 receptor for CXCL1 is expressed in the brain and spinal cord by neurons and oligodendrocytes and during CNS pathologies such as Alzheimer's disease, multiple sclerosis and brain injury also by microglia. An initial study in mice showed evidence that CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function.
The CXCR2 receptor for CXCL1 is found in the brains and spinal cords of neurons, oligodendrocytes, and microglia, as well as during conditions like Alzheimer's disease, multiple sclerosis, and brain injury. Research on mice revealed that CXCL1 may help alleviate symptoms of multiple sclerosis and provide neuroprotection.