GDF2 activate JNK in osteogenic differentiation of mesenchymal progenitor cells (MPCs). GDF2 also triggers p38 and ERK activation who will modulate de Smad pathway, p38 increase the phosphorylation of Smad 1,5,8 by GDF2 whereas ERK has the opposite effect.
GDF2 activates JNK in osteogenic differentiation of mesenchymal progenitor cells (MPCs). GDF2 initiates p38 and ERK activation, which will regulate the Smad pathway. P38 increases the phosphorylation of Smad 1,5,8 by GDF2, whereas ERK has the opposite effect.