Thus, at high concentrations, ATP outcompetes the drug. One limitation of traditional coumarins is gyrB ability to confer antibiotic resistance due to mutations and as a result decrease the inhibitor's ability to bind and induce cell death.
At high concentrations, ATP outcompetes the drug.  A limitation of traditional coumarins is their ability to confer antibiotic resistance due to mutations and as a result decrease the inhibitor's ability to bind and induce cell death.