All of the components of the gamma-secretase complex undergo extensive post-translational modification, especially proteolytic activation; APH-1 and PEN-2 are regarded as regulators of the maturation process of the catalytic component presenilin.
Post-translational modifications, particularly proteolytic activation, impact all components of the gamma-secretase complex; APH-1 and PEN-2 oversee the maturation process of presenilin.