If the pressure becomes great enough, blood flow to the muscle can be blocked, leading to a condition known as compartment syndrome. Severe damage to the nerve and blood vessels around a muscle can cause the muscle to die and amputation might be necessary.
In situations where pressure becomes extremely high, it can cut off blood flow to the muscle, leading to compartment syndrome. Severe injury to the nerves and blood vessels surrounding the muscle can result in muscle tissue death, potentially requiring surgical removal.