Donnolo is one of the earliest Jewish writers on medicine, and one of the few Jewish scholars of Southern Italy at this early time. What remains of his medical work, Sefer ha-Yaqar "Precious Book", was published by Moritz Steinschneider in 1867, from MS. 37, Plut.
Donnolo's work as a Jewish scholar of medicine is significant because he represents one of the few individuals from Southern Italy to have made notable contributions to the field at that early period. His medical writings, "Sefer ha-Yaqar", were later published by Moritz Steinschneider in 1867.