By far the most famous case he prosecuted as district attorney was H. H. Holmes, one of America's first serial killers. Although Holmes confessed to killing twenty-seven men, women, and children, he was only tried for killing his business partner, Benjamin Pitezel. Graham worked closely with Detective Frank Geyer and requested he search for Pitezel's missing three children, whom Holmes took temporary custody of after Benjamin's death.
The most renowned case he handled as district attorney was H. H. Holmes, one of America's earliest serial killers. Although Holmes admitted to murdering twenty-seven men, women, and children, he was only charged with killing his business partner, Benjamin Pitezel. Graham collaborated closely with Detective Frank Geyer and asked him to look for the missing three children that Holmes had temporarily taken custody of after Benjamin's death.