For , from the city of Terre Haute until it rejoins U.S. Route 41 (US 41) near Carbondale, it is a four-lane divided highway and replaces US 41 as the major north–south artery in this portion of the state.
This stretch of , originating from Terre Haute, merges with U.S. Route 41 (US 41) near Carbondale, becoming a four-lane divided road and assuming the role of the main north-south route in this area.