Already populated in ancient Roman times, in the Middle Ages the area of Cavenago d'Adda belonged to the bishop of Lodi (10th century), and was later a fief of the family of Fissiraga (1297–1482), the Bocconi of Mozzanica, and finally of the Cavenaghi Clerici.
Cavenago d'Adda has a history marked by different rulers throughout time: Roman, bishop of Lodi, Fissiraga family, Bocconi of Mozzanica, and finally the Cavenaghi Clerici.