IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association domain and several regulatory phosphorylation sites.
IRF3 was initially identified as a homologue of IRF1 and IRF2. IRF3 has been more thoroughly studied and revealed to possess several functional regions, including a nuclear export signal, a DNA-binding domain, an IRF association domain at its C-terminus, and multiple regulatory phosphorylation sites.