MD 300 crosses Andover Branch and curves to the northeast at Busic Church Road to its eastern terminus at the Delaware state line, where Sudlersville Road continues east as DE 300 toward the town of Smyrna.
MD 300 runs along Andover Branch and makes a turn to the northeast at Busic Church Road, concluding at the state line, where Sudlersville Road continues east as DE 300 toward Smyrna.