Typically, low molecular weight proteins are displaced by high molecular weight protein while the opposite, high molecular weight being displaced by low molecular weight, does not occur. A typical example of this occurs when fibrinogen displaces earlier adsorbed proteins on a biopolymer surface and is later replaced by high molecular weight kininogen.
Typically, smaller-sized proteins are evicted by larger-sized proteins whereas the opposite scenario does not occur frequently. A classic case of this phenomenon can be seen when fibrinogen displaces earlier adsorbed proteins on a polymer surface and is later replaced by high molecular weight kininogen.