CNO activates the excitatory Gq- coupled DREADDs: hM3Dq, hM1Dq and hM5Dq and also the inhibitory hM4Di and hM2Di Gi-coupled DREADDs.
CNO activates the stimulatory Gq-coupled DREADDs: hM3Dq, hM1Dq, and hM5Dq, as well as the inhibitory Gi-coupled DREADDs: hM4Di and hM2Di.