Molecular phylogenetic investigations have also demonstrated Gomphidiaceae are nested well within Boletales, being more closely related to Suillaceae than to Boletaceae, a finding that is supported by chemotaxonomic investigation of these groups.
Research into molecular phylogeny has indicated that Gomphidiaceae are intricately placed within the Boletales family, with closer ties to Suillaceae rather than Boletaceae. This conclusion is also backed by chemotaxonomic studies examining these groups.