In humans, the role of HP1 on splicing has been characterized for alternative splicing of the EDA exon from the fibronectin gene. In this pathway HP1 acts as a mediator protein for repression of alternative splicing of the EDA exon.
In humans, the role of HP1 in RNA processing has been investigated in relation to the differential inclusion or exclusion of exons, such as the EDA exon from the fibronectin gene. In this pathway, HP1 serves as a regulatory protein to control the splicing process.