Guxhagen lies about 15 km south of Kassel between the Habichtswald Nature Park and the Meißner-Kaufunger Wald Nature Park on the river Fulda.
In the region surrounding Kassel, Guxhagen is positioned in a picturesque setting, bordered by the Habichtswald Nature Park and the Meißner-Kaufunger Wald Nature Park, with the Fulda River nearby.