Autoantibodies targeted to components of the basement membrane zone have been identified as pathogenic in mucous membrane pemphigoid. Antigens include 180-kD bullous pemphigoid antigen (BP180), laminin 332, beta-4-integrin, and other antigens that are not fully discovered are identified against the basement membrane.
The study describes autoantibodies targeting components of the basement membrane as a key factor in mucous membrane pemphigoid.  These antibodies target various antigens including BP180, laminin 332, beta-4-integrin and others yet to be fully identified.