The polyketide backbone was synthesized by type I polyketide synthase (PKS) and the thiazole ring was derived from a cysteine incorporated by a nonribosomal peptide synthetase (NRPS).
The polyketide backbone was created by type I polyketide synthase (PKS), and the thiazole ring was formed from a cysteine processed by a nonribosomal peptide synthetase (NRPS).