In line with its dopaminergic neurotoxicity, methamphetamine use is associated with a higher risk of Parkinson's disease. In addition to its dopaminergic neurotoxicity, a review of evidence in humans indicated that high-dose methamphetamine use can also be neurotoxic to serotonergic neurons.
The relationship between methamphetamine's neurotoxic effects and Parkinson's disease is grounded in its damage to dopamine-producing neurons. Moreover, research suggests that high-dose methamphetamine use can also be detrimental to serotonin-producing neurons.