MD 481 begins at an intersection with MD 309 (Starr Road) north of Queen Anne. The two-lane undivided state highway heads north through farmland, passing Crouse Mill Road, which is used to access Tuckahoe State Park from the west.
MD 481 starts at an intersection with MD 309 (Starr Road), located north of Queen Anne. As it heads north through countryside, it passes by Crouse Mill Road, providing a route into Tuckahoe State Park from the western side.