The effect of these changes on drug protein binding and drug delivery, however, appear to be minimal. AGP shows a complex interaction with thyroid homeostasis: AGP in low concentrations was observed to stimulate the thyrotropin (TSH) receptor and intracellular accumulation of cyclic AMP. High AGP concentrations, however, inhibited TSH signalling.
These changes in AGP have a complex effect on drug protein binding and drug delivery, but they appear to be minimal.  AGP interacts with thyroid homeostasis in a complex way: low concentrations stimulate the TSH receptor and increase cyclic AMP levels. High concentrations, however, inhibit TSH signaling.