The RRM domain in its carboxylic region attaches to the SMAD (protein) proteins, which is involved in mediating TGF-β cellular signalling. Consequently, LEMD3 indirectly regulates downstream genes.
The RRM domain in its carboxylic region connects with the SMAD (protein) proteins, which is part of the process that regulates TGF-β cellular signaling. Consequently, LEMD3 affects the expression of downstream genes.