Although Hormone-Sensitive Lipase (HSL) is able to catalyze hydrolysis of triglycerides and diglycerides, another enzyme found in adipose tissue, Adipose triglyceride lipase (ATGL), has a higher affinity for triglycerides than HSL, and ATGL predominantly acts as the enzyme for triglyceride-specific hydrolysis in the adipocyte. Hormone-sensitive lipase, which has 11-fold greater affinity for diglycerides than triglycerides, predominantly cleaves these diglycerides, forming 2-monoglyceride and a free fatty acid.
Although Hormone-Sensitive Lipase (HSL) can catalyze triglyceride and diglyceride hydrolysis, another enzyme in adipose tissue, Adipose Triglyceride Lipase (ATGL), has a stronger attraction to triglycerides than HSL. ATGL primarily performs triglyceride-specific hydrolysis within adipocytes. Hormone-Sensitive Lipase, which binds 11 times more strongly to diglycerides than triglycerides, mainly breaks down these diglycerides into 2-monoglyceride and a free fatty acid.