TREs have been shown to occur during DNA replication in both in vitro and in vivo studies, allowing for these long tracts of triplet repeats to assemble rapidly in different mechanisms that can result in either small scale or large scale expansions.
The occurrence of TReS (triplet repeat expansions) has been documented during DNA replication, both in vitro and in vivo studies. These expansions can occur through different mechanisms, resulting in either small-scale or large-scale increases in the number of repeats.