Canistro, located in the Roveto valley, borders to the north with Capistrello and the frazione of Pescocanale, to the east with the municipality of Luco dei Marsi, to the south with Civitella Roveto and to the west with the mountainous territory of Filettino, in Lazio, from which it is separated from the Simbruini mountains.
Canistro is located within the Roveto valley, bordering Capistrello to the north, Pescocanale to the east, Luco dei Marsi to the east, Civitella Roveto to the south, and Filettino in Lazio to the west, separated from the Simbruini mountains by this region.