These two proteins homeostatically control miRNA biogenesis by an auto-feedback loop. A 2nt 3' overhang is generated by Drosha in the nucleus recognized by Dicer in the cytoplasm, which couples the upstream and downstream processing events.
Two proteins work together to control the production of microRNAs (miRNA) by creating a feedback loop.  Drosha creates a 2nt 3' overhang in the nucleus, which is recognized by Dicer in the cytoplasm. This process couples the initial processing steps with the final ones.