Pharmacokinetic data of oral trifluridine have only been evaluated in combination with tipiracil, which significantly affects biotransformation of the former. At least 57% of trifluridine are absorbed from the gut, and highest blood plasma concentrations are reached after two hours in cancer patients.
The pharmacokinetic properties of oral trifluridine have been investigated only when combined with tipiracil, which significantly influences its metabolism.  At least 57% of trifluridine is absorbed from the gut, and peak blood plasma concentrations are achieved after two hours in cancer patients.