Tsongas is pro-choice and received a 100% approval rating from Planned Parenthood in 2008. A supporter of LGBT rights, she cosponsored the Respect for Marriage Act to repeal the Defense of Marriage Act; and voted for the Don't Ask, Don't Tell Repeal Act of 2010, which allows gays and lesbians to serve openly in the United States Armed Forces.
Tsongas holds progressive views on women's rights and has received full backing from Planned Parenthood in 2008. As a supporter of equality, she sponsored the Respect for Marriage Act and voted for the Don't Ask, Don't Tell Repeal Act, allowing LGBTQ+ individuals to serve openly.