After founding of nearby Hermoupolis, Ano Syros ceased to be the administrative centre of Syros. Nevertheless, the settlement remained a religious centre since it is the seat of Roman Catholic Diocese of Syros and Milos.
After establishing Hermoupolis, Ano Syros lost its administrative status as the center of Syros, but remained a vital religious location due to its role as the seat of the Roman Catholic Diocese of Syros and Milos.