Corticosteroids inhibit inflammatory cytokines, chemokines, adhesion molecules, and other inflammatory mediators. They also reduce synthesis of histamine, stabilize cell membranes, and inhibit degranulation of mast cells. Recent work suggests that the activated corticosteroid-GR complex also elicits nongenomic effects, particularly the inhibition of vasodilation, vascular permeability, and migration of leukocytes.
Corticosteroids suppress inflammatory cytokines, chemokines, adhesion molecules, and other mediators of inflammation. They also reduce histamine production, stabilize cell membranes, and inhibit mast cell degranulation. Recent research indicates that the activated corticosteroid-GR complex can elicit non-genomic effects, particularly inhibiting vasodilation, vascular permeability, and leukocyte migration.