Edwards ran for a full term in November 2008, defeating Republican candidate Peter James with 85% of the vote. She ran for U.S. Senate in 2016 in the primary to replace retiring Barbara Mikulski instead of running for re-election to her Congressional seat but was defeated by Congressman Chris Van Hollen in the Democratic primary.
Edwards participated in a comprehensive campaign in November 2008, emerging victorious against Republican candidate Peter James with an overwhelming majority of 85% of the vote. She pursued a seat in the U.S. Senate in 2016 as part of the primary election to replace retiring Senator Barbara Mikulski rather than seeking re-election to her congressional position but was ultimately defeated by Congressman Chris Van Hollen in the Democratic primary.