When in the bloodstream, 96,6% of the substance are bound to blood plasma proteins. Its main metabolite is silodosin glucuronide, which inhibits the α1A receptor with 1/8 of the affinity of the parent substance.
When circulating in the circulatory system, 96.6% of the substance is attached to plasma proteins in the blood. Its primary breakdown product is silodosin glucuronide, which blocks the α1A receptor with one-eighth of the potency of the parent compound.