These mutations cause for the deficiency of 3-methylglutaconyl-CoA hydratase which leads to the amalgamation of  3-methylglutaconyl-CoA, 3-methylglutaric acid, and 3-hydroxyisovaleric acid which eventually leads to 3-Methylglutaconic Acuduria Type 1.
These mutations lead to a deficiency in 3-methylglutaconyl-CoA hydratase, resulting in the formation of 3-methylglutaconyl-CoA, 3-methylglutaric acid, and 3-hydroxyisovaleric acid, culminating in 3-Methylglutaconic Aciduria Type 1.