Sironko is approximately  by road, northeast of the city of Mbale on the highway between Mbale and Moroto. This is approximately , by road, northeast of Kampala, Uganda's capital and largest city.
Sironko lies roughly midway by road, northeast of Mbale town on the highway connecting Mbale to Moroto. It is situated around , by road, northeast of Kampala, the capital and largest metropolis in Uganda.