The Cascade Range forms its western boundary with the Palouse regions bordering the area to the east. To the north, the Okanogan–Wenatchee National Forest forms a border with the AVA and Canada. It encompasses the valleys formed by the Columbia River and its tributaries, including the Walla Walla River, the Snake River, and the Yakima River.
The Cascade Range borders the Palouse regions to the east, while the Okanogan–Wenatchee National Forest forms a northern boundary with the AVA and Canada. The region is characterized by valleys carved by the Columbia River and its tributaries, including the Walla Walla River, Snake River, and Yakima River.