AII amyloid can be induced in mice by a variety of β-sheet rich amyloid fibrils, and cerebral tauopathy can be induced by brain extracts that are rich in aggregated Aβ. There is also experimental evidence for cross-seeding between prion protein and Aβ. In general, such heterologous seeding is less efficient than is seeding by a corrupted form of the same protein.
AII amyloid can be induced in mice through different β-sheet-rich amyloid fibrils, while cerebral tauopathy can be triggered by brain extracts rich in aggregated Aβ. There's also evidence that prion protein and Aβ can cross-seed each other. Typically, this mixed seeding is less effective than using a corrupted form of the same protein.