Here, the route intersects with June Road (unsigned County Route 310 or CR 310). Beginning a parallel with the Titicus River, NY 121 soon reaches a junction with NY 116, which become concurrent as NY 121 bypasses the hamlet of North Salem.
Here, June Road (unsigned County Route 310 or CR 310) intersects with the route. Following a parallel path along the Titicus River, NY 121 eventually meets NY 116, which then become concurrent as NY 121 bypasses North Salem.