With Craig Kundrot, Richards investigated the effects of high pressure (1000 atmospheres) on protein structure, using hen-egg lysozyme crystals, finding that the structure was robust to such pressures apart from a quite modest compaction in size.
To study the impact of high pressure (1000 atmospheres), Craig Kundrot and Richards used hen-egg lysozyme crystals. Their research revealed that the protein's structure remained intact under these conditions, with only a minor decrease in size.