CD8αα homodimer is an alternative isoform to classical CD8αβ heterodimer, which is expressed on conventional CD8 T-cells. CD8αα is mainly expressed by effector or mature antigen-experienced cells in the gut.
CD8αα homodimer functions as a variant of the classical CD8αβ heterodimer, both of which are present on conventional CD8 T-cells. CD8αα is predominantly observed in effector or mature antigen-experienced cells located in the gut.