Therefore, it is not surprising that NFAT2 lymphocytes specific ablation causes a defect of the BCR-mediated proliferation but whether this phenotype is caused by sole dysregulation of Tfh or B cells or combination of both is uncertain.
Given the fact that eliminating NFAT2 lymphocytes specifically leads to a problem with B cell proliferation triggered by the BCR, it's uncertain if this effect is solely due to Tfh cell dysfunction or B cell dysfunction itself, or a combination of both.