The administration of folinic acid, which forces the methylation of CXCL 16, induces high levels of methylation of the CXCL 16 gene promoter in colon, ileum and lung and causes iNKT cells accumulation in these tissues.
Folinic acid administration induces the methylation of CXCL 16, causing high levels of methylation at the CXCL 16 gene promoter in colon, ileum, and lung tissues. This results in an accumulation of iNKT cells in these same tissues.