Upon binding to the LTβ receptor, LT-αβ transmits signals leading to proliferation, homeostasis and activation of tissue cells in secondary lymphoid organs through induced expression of chemokines, major histocompatibility complex, and adhesion molecules. LT-αβ, which is produced by activated TH1, CD8+ T cells, and natural killer (NK) cells, is known to have a major role in the normal development of Peyer's patches.
Upon binding to the LTβ receptor, LT-αβ triggers signals that promote cell proliferation, maintenance, and activation within secondary lymphoid organs by inducing the expression of chemokines, major histocompatibility complex, and adhesion molecules. This molecule, produced by activated T helper 1 (TH1), CD8+ T cells, and natural killer (NK) cells, plays a vital role in the development of Peyer's patches.