Tetrahydrofolate gets this extra carbon atom by sequestering formaldehyde produced in other processes. These single-carbon moieties are important in the formation of precursors for DNA synthesis. A shortage in tetrahydrofolic acid (FH4) can cause megaloblastic anemia.
Tetrahydrofolate acquires its extra carbon atom by capturing formaldehyde generated in other processes. These single-carbon groups are crucial for DNA synthesis precursors. A deficiency of tetrahydrofolic acid (FH4) can lead to megaloblastic anemia.