The route passes through rural areas of southeastern Sussex County along with the communities of Dagsboro, Millville, Ocean View and Bethany Beach. DE 26 intersects DE 54 in the Gumboro area, U.S. Route 113 (US 113) and DE 20 in Dagsboro, and DE 17 west of Millville.
The route traverses through rural Sussex County's southeastern areas, passing by communities such as Dagsboro, Millville, Ocean View, and Bethany Beach. It intersects with DE 26 and DE 54 in the Gumboro area, and also meets US 113 and DE 20 in Dagsboro, while DE 17 is situated to the west of Millville.