In mammals, chromodomain-containing proteins are responsible for aspects of gene regulation related to chromatin remodeling and formation of heterochromatin regions. Chromodomain-containing proteins also bind methylated histones and appear in the RNA-induced transcriptional silencing complex. In histone modifications, chromodomains are very conserved.
Mammalian genes are regulated by proteins that contain a specific domain, which is involved in chromatin remodeling and heterochromatin formation. These proteins also interact with methylated histones and participate in the RNA-induced transcriptional silencing complex. The structure of these domains remains highly conserved across different histone modifications.