In addition, there are a number of genes which contain multiple promoter and enhancer regions each regulated by a different HNF. Furthermore, efficient expression of these genes require synergistic activation by multiple HNFs. Hence hepatocyte nuclear factors function to ensure liver specific expression of certain genes.
The text highlights the importance of coordinated regulation of gene expression in the liver. Specifically, it explains that certain genes require simultaneous activation from multiple HNFs to be expressed efficiently. This underscores the role of hepatocyte nuclear factors in ensuring the specific expression of these genes in liver cells.