In their landmark 1987 paper, Hon Cheung Lee and colleagues discovered not one but two Ca2+-mobilizing second messengers, cADPR and NAADP from the effects of nucleotides on Ca2+ release in sea urchin egg homogenates. It turns out that NAADP was a contaminant in commercial sources of NADP, but it was not until 1995 that its structure was solved.
In their groundbreaking 1987 research, Hon Cheung Lee and colleagues found two Ca2+-mobilizing second messengers: cADPR and NAADP. These were discovered through nucleotide-induced Ca2+ release in sea urchin egg homogenates. It was not until 1995 that the structure of NAADP was solved, revealing it to be a contaminant in commercial NADP sources.