However, people whose CrCl levels are less than 50ml/min should not follow this dosage. Instead, patients should be prescribed drug components of the fixed-dose combinations while adjusting TDF and FTC doses according to the patient's CrCl levels.
For individuals with CrCl levels lower than 50 ml/min, a different dosage regimen is required.  Instead of taking the standard dose, they should receive the drug components in fixed-dose combinations, and their TDF and FTC dosages will be adjusted according to their individual CrCl levels.