The rate of mass transfer per area unit is, among other factors, related to the shape of polymeric chains within the dosage form. Higher tortuosity or curviness retards mass transfer as it acts obstructively on the drug particles within the formulation.
The rate of mass transfer per unit area is affected by the shape of polymeric chains within the dosage form. Higher tortuosity or curvature slows down the movement of drug particles due to obstruction.