A mutation of the IRF6 gene can lead to the autosomal dominant van der Woude syndrome (VWS)  or the related popliteal pterygium syndrome (PPS). Van der Woude syndrome can include cleft lip and palate features along with dental anomalies and lip fistulas.
A mutation in the IRF6 gene is associated with both van der Woude syndrome (VWS) and related popliteal pterygium syndrome (PPS). VWS can include features like cleft lip and palate, dental anomalies, and lip fistulas.