For example, the (R)- and (S)-enantiomers of 1-phenylethanol react with (S)-Mosher acid chloride to yield (R,S)- and (S,S)-diastereomers, respectively, that are distinguishable in NMR.
To illustrate, the (R)- and (S)-forms of 1-phenylethanol combine with (S)-Mosher acid chloride to form (R,S)- and (S,S)-diastereomeric compounds, which can be distinguished through nuclear magnetic resonance (NMR) analysis.