In north-central Des Moines, it intersects US 69 and I-235. In northeast Des Moines, it turns to the northeast along Hubbell Avenue, which takes US 6 to Altoona.
In north-central Des Moines, Interstate 235 connects with US Highway 69 and I-235. In northeast Des Moines, it shifts direction along Hubbell Avenue, which serves as a pathway for US Highway 6 to Altoona.