The church was the site of the nomination of Pope Leo IX in 1048 and of the conclusion of the 1122 Concordat of Worms ending the Investiture Controversy. In 1235 the marriage of Emperor Frederick II with Isabella of England took place here.
The church played a pivotal role in two significant events: the nomination of Pope Leo IX in 1048 and the conclusion of the 1122 Concordat of Worms, which resolved the Investiture Controversy. Another notable event occurred at this location in 1235 when Emperor Frederick II married Isabella of England.