It is very similar to The MCA Years: A Retrospective but with several different tracks. Two of the tracks on The Best of Nanci Griffith had previously never been released on any album.
The compilation bears a strong resemblance to The MCA Years: A Retrospective but features an assortment of different tracks. Two of the tracks on The Best of Nanci Griffith were previously unissued and appeared only in this specific release.