TIM1, TIM4, ICOS, CD3 or DR3 and several molecules from the SLAM family were shown to induce polarization towards TH2. In contrast, CD27 and HVEM promote TH1 polarization.
The involvement of TIM1, TIM4, ICOS, CD3 or DR3, and several SLAM family members in promoting TH2 responses is notable. Conversely, CD27 and HVEM have been linked to the promotion of TH1 responses.