Although not all causes of SGBS have been identified, one cause of SGBS type I is a mutation of the glypican-3 gene (GPC3) on the X chromosome locus q26.1.
While the exact causes of SGBS are still being investigated, one known cause of SGBS type I is a mutation in the glypican-3 gene (GPC3), located on the X chromosome at position q26.1.