The malfunctions in CSNB1 specifically affect the ON pathway, by hindering the ability of ON-type bipolar cells to detect neurotransmitter released from photoreceptors. Rods, which are responsible for low-light vision, make contacts with ON-type bipolar cells only, while, cones, which are responsible for bright-light vision, make contacts with bipolar cells of both ON an OFF subtypes.
The malfunctions in CSNB1 influence the ON pathway by diminishing the ability of ON-type bipolar cells to detect neurotransmitter from photoreceptors. Rods, which are crucial for low-light vision, link exclusively with ON-type bipolar cells, whereas cones, essential for bright-light vision, connect with both ON and OFF subtype bipolar cells.