Many malignancies of the soft tissues are challenging for the pathologist to diagnose through gross examination and microscopy alone, and additional tools such as immunohistochemistry, electron microscopy, and molecular pathology techniques are sometimes employed to obtain a definitive diagnosis.
Soft tissue malignancies frequently require more than visual inspection and microscopic analysis for accurate diagnosis; therefore, supplementary methods like immunohistochemistry, electron microscopy, and molecular pathology are often employed to confirm the diagnosis.