In 562, when the warlord Zhou Di (), who controlled parts of modern Jiangxi, rebelled, Wu was made the governor of Jiang Province (江州, roughly modern Jiujiang), to command the army against Zhou. However, the strict Wu was unable to get his subordinate generals to obey his orders, and Emperor Wen subsequently sent his brother Chen Xu the Prince of Ancheng to replace Wu.
In 562, when warlord Zhou Di revolted, Wu was appointed governor of Jiang Province to lead the army against him. However, Wu's strict leadership style proved ineffective in commanding his subordinates, and Emperor Wen subsequently sent Chen Xu, the Prince of Ancheng, to replace Wu.