A ubiquitous form of the protein in mammals, CALM, (Clathrin-assembly lymphoid myeloid leukaemia protein) is named after its association with myeloid and lymphoid leukemias where some translocations map to this gene. The C-terminus of AP180 is a powerful and specific inhibitor of clathrin-mediated endocytosis.
CALM, a protein found in mammals, is associated with myeloid and lymphoid leukemias, and its name reflects this connection. AP180's C-terminus acts as a potent and specific inhibitor of clathrin-mediated endocytosis.