While it is accepted that modifications (such as methylation, acetylation, ADP-ribosylation, ubiquitination, citrullination, SUMO-ylation and phosphorylation) to histone tails alter chromatin structure, a complete understanding of the precise mechanisms by which these alterations to histone tails influence DNA-histone interactions remains elusive.
Although it is widely recognized that various modifications (such as methylation, acetylation, ADP-ribosylation, ubiquitination, citrullination, SUMO-ylation and phosphorylation) applied to histone tails alter chromatin structure, a thorough understanding of the precise mechanisms by which these changes impact DNA-histone interactions remains unexplained.