Mackaill rose to leading-lady status in the drama The Man Who Came Back (1924), opposite rugged matinee idol George O'Brien. In 1924, she also starred in the western film The Mine with the Iron Door, shot on location outside of Tucson, Arizona.
Mackaill's career gained momentum when she played a leading role in the drama The Man Who Came Back (1924), opposite the charming George O'Brien. She also starred in the western film The Mine with the Iron Door that year, filmed on location in the Arizona desert near Tucson.