The construction of the chapel was promoted by eminent physician Girolamo Mercuriali, with his son Massimiliano, to honour the Saints Girolamo and Mercuriale. The chapel was finished in 1606, the same year of the death of Mercuriali who wanted to be buried in it.
The construction of the chapel was initiated by physician Girolamo Mercuriali and his son Massimiliano as a memorial to Saints Girolamo and Mercuriale. The chapel was completed in 1606, coinciding with the death of Mercuriali who desired burial within its walls.