It comes close to the hamlet of Cairo, but bypasses it on a four-lane divided highway that takes it around the northern fringe of the community. As it runs around Cairo, the route connects to NY 145 and briefly overlaps NY 32, the major north–south state route on the west side of the Hudson River.
The road nearly reaches the hamlet of Cairo but takes a bypass on a four-lane divided highway that goes around the northern edge of the community. As it skirts around Cairo, the route links to NY 145 and briefly shares a path with NY 32, a major north–south state road on the west side of the Hudson River.