Mitochondrial acetoacetyl-CoA thiolase, also known as thiolase II, the enzyme responsible for catalyzing the synthesis of acetoacetyl-CoA within ketogenesis as mentioned, is also involved within acetoacetyl-CoA cleavage in ketolysis. It is observed to play a role within cleavage of acetyl-CoA from acetoacetyl-CoA and 2-methylacetoacetyl-CoA.
The enzyme mitochondrial acetoacetyl-CoA thiolase II, also referred to as thiolase II, plays a crucial role in ketogenesis by synthesizing acetoacetyl-CoA. Additionally, it participates in the breakdown of acetyl-CoA from acetoacetyl-CoA and 2-methylacetoacetyl-CoA.