Jeffersonia diphylla is native to Eastern North America where it is found from Minnesota east to New York and south to Tennessee. In Minnesota it grows in the lower southeastern section of the state in mesic deciduous forests and most commonly in ravines or on talus slopes.
Jeffersonia diphylla inhabits Eastern North America, stretching from Minnesota to New York and south to Tennessee. In Minnesota, it is commonly found in the southeastern part of the state within mesic deciduous forests and ravines or talus slopes.