Schafer wrote that "Coma White" displays "all of Manson's favorite themes — the seductive evil of prescription medication, lost love, [and] the paralyzing effect of celebrity culture". Craig Hlavaty wrote in the Houston Press that the song is about the assassination of John F. Kennedy.
Schafer and Hlavaty both analyzed "Coma White" by Manson, with Schafer highlighting its themes of prescription drug addiction, lost love, and celebrity culture's influence, while Hlavaty suggested it was inspired by the assassination of John F. Kennedy.