She was active in Philadelphia and exhibited her work in the city at the Pennsylvania Academy of the Fine Arts and in New York and Washington, D.C. Greenwood painted portraits, especially of young women, floral still lifes, and landscapes. She painted with oils on canvas and over her career her brush strokes became more free and expressive.
Greenwood was engaged in Philadelphia activities and displayed her artwork at the Pennsylvania Academy of the Fine Arts in the city as well as in New York and Washington, D.C. She specialized in portraits, especially those of young women, floral still lifes, and landscapes. Throughout her career, she painted with oils on canvas, and her brushwork became more fluid and expressive.