Once the tumor is seeded in the bone, the tumor cells stimulate bone resorption by secreting factors such as RANKL or prompting the surrounding stroma to express growth factors. These growth factors then upregulate production of RANKL which leads to osteoclastogenesis and bone destruction.
When a tumor takes hold in the bone, it stimulates bone resorption through the secretion of factors such as RANKL or by prompting the stroma to produce growth factors. These growth factors then boost RANKL levels, leading to osteoclast formation and bone degradation.