More recently, it has been shown that Cxcl3 regulates cell autonomously the migration of the precursors of cerebellar granule neurons toward the internal layers of cerebellum, during the morphogenesis of cerebellum. Moreover, if the expression of Cxcl3 is reduced in cerebellar granule neuron precursors, this highly enhances the frequency of the medulloblastoma, the tumor of cerebellum.
This has been shown more recently that Cxcl3 autonomously regulates the migration of cerebellar granule neuron precursors towards the internal layers of the cerebellum during its formation. Moreover, a decrease in Cxcl3 expression in these precursor cells significantly increases the frequency of medulloblastoma.