These cytokines induce the activation of transcription factors which push completion of the monoblast's myeloid cell fate. Monoblasts are normally found in bone marrow and do not appear in the normal peripheral blood. They mature into monocytes which, in turn, develop into macrophages.
The process described involves cytokines that initiate the transformation of monoblasts into myeloid cells. These cells originate from the bone marrow and are not found in the bloodstream. Monoblasts mature into monocytes, which eventually differentiate into macrophages.