Allentown Central Catholic competes athletically in the Eastern Pennsylvania Conference (EPC) in the District XI division of the Pennsylvania Interscholastic Athletic Association (PIAA), one of the premier high school athletic divisions in the nation.
Within the Eastern Pennsylvania Conference (EPC) and District XI of the Pennsylvania Interscholastic Athletic Association (PIAA), Allentown Central Catholic competes in athletic events, which are among the most distinguished high school sporting leagues nationwide.