South Omo is bordered on the south by Kenya, on the southwest by the South Sudan, on the west by Bench Maji, on the northwest by Keffa, on the north by Konta, Gamo Gofa and Basketo, on the northeast by Dirashe and Konso, and on the east by the Oromia Region.
South Omo is surrounded by Kenya on its southern border, South Sudan in the southwest, Bench Maji to the west, Keffa to the northwest, Konta, Gamo Gofa, and Basketo to the north, Dirashe and Konso to the northeast, and Oromia Region to the east.