The drug is highly cardioselective at 5 mg. In addition, at doses above 10 mg, nebivolol loses its cardioselectivity and blocks both β1 and β2 receptors, while the recommended starting dose of nebivolol is 5 mg, sufficient control of blood pressure may require doses up to 40 mg.
Nebivolol exhibits pronounced preference for β1 receptors at a dosage of 5 mg. However, at doses above 10 mg, it loses this selectivity and affects both β1 and β2 receptors, with the starting dose of 5 mg often being insufficient to control blood pressure effectively, potentially requiring higher doses up to 40 mg.