He served as Minister for Trade in the 1961–1963 Konstantinos Karamanlis cabinet and, following Karamanlis' resignation and self-exile, Pipinelis served briefly as an interim Prime Minister of Greece from 17 June 1963 to 29 September 1963. On 20 November 1967 he was appointed as Minister of Foreign Affairs during the dictatorship.
He held the position of Trade Minister in the 1961–1963 Konstantinos Karamanlis government, subsequently assuming a brief tenure as interim Prime Minister of Greece from June 17, 1963, to September 29, 1963. Following Karamanlis' resignation and self-imposition into exile, Pipinelis was appointed Minister of Foreign Affairs in November 20, 1967, during the regime.