In 1953, Paul Fatt and Bernard Katz discovered voltage gated calcium channels in crustacean muscle. The channels exhibited different activation voltages and calcium conducting properties and were thus separated into High Voltage Activating channels (HVA) and Low Voltage Activating channels (LVA). After further experimentation, it was found that HVA channels would open to 1,4-dihydropyridine (DHPs).
In 1953, Paul Fatt and Bernard Katz identified voltage-sensitive calcium channels in crustacean muscle. The channels displayed varying activation voltages and calcium-conducting characteristics and were thus categorized into High Voltage Activating channels (HVA) and Low Voltage Activating channels (LVA). Subsequent research revealed that HVA channels would open to 1,4-dihydropyridine (DHPs).