Antonino was treasurer of the Antonino Construction Enterprises (1946–1953); secretary-treasurer, then manager, Western Mindanao Lumber Co.; general manager, G. E. Antonio, Inc., treasurer, Polytechnic Colleges of the Philippines; director, Philippine Commercial and Industrial Bank, and Luzon Cement Corporation.
Antonino held various financial and managerial positions throughout his career, including treasurer for Antonino Construction Enterprises from 1946 to 1953, secretary-treasurer and manager at Western Mindanao Lumber Co., general manager of G. E. Antonio, Inc., treasurer of Polytechnic Colleges of the Philippines, director of Philippine Commercial and Industrial Bank, and Luzon Cement Corporation.