Upon reaching the east bank of the Susquehanna River, the route enters the town of Perryville and passes over residential areas and Norfolk Southern's Port Road Branch railroad line before descending off the Thomas J. Hatem Memorial Bridge, where it passes a pair of weigh stations. US 40 becomes state-maintained again and follows four-lane divided Pulaski Highway northeast to an intersection with MD 222. Following this, the road passes through business areas with some woodland to the south.
As one approaches the eastern bank of the Susquehanna River, the route enters the town of Perryville and proceeds through residential neighborhoods and Norfolk Southern's Port Road Branch railroad line before descending from the Thomas J. Hatem Memorial Bridge, where it encounters a pair of weigh stations. US 40 resumes state maintenance and follows four-lane divided Pulaski Highway northeast to an intersection with MD 222. Subsequently, the road passes through commercial districts with some woodland to the south.