This gene and MAPK8 are also known as c-Jun  N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells.
This gene, MAPK8, is also known as c-Jun N-terminal kinases. This kinase inhibits the ubiquitination of tumor suppressor p53, thereby increasing the stability of p53 in nonstressed cells.