As of 2017, Ctenophryne includes two other genera, Nelsonophryne and Melanophryne, in synonymy. The latter might represent valid genera, but molecular analyses could not resolve their relationships in a robust way.
In 2017, Ctenophryne was found to include two additional genera: Nelsonophryne and Melanophryne. While the latter may represent legitimate genera, molecular studies haven't provided a clear picture of their evolutionary connections.