In his second season with the club, the 26-year-old Ledesma, was hampered by injuries, and found playing time harder to come by under Siniša Mihajlović, as he was not fully fit for the majority of the season. Ledesma made just 16 appearances in the duration of the 2009–10 Serie A season, but helped to guide Catania to a 13th place league finish, also reaching a record points total for the club. He has since re-established himself back into Catania's starting line-up and made 30 appearances during the 2010-11 campaign, bringing his total appearances for the club up to 74, helping the club to a 13th-place finish in the league and a record points total in Serie A for a third consecutive season.
In his second season with the club, the 26-year-old Ledesma was hindered by injuries and struggled to find playing time under Siniša Mihajlović. He made just 16 appearances in the 2009–10 Serie A season but assisted Catania in securing a 13th place league finish, also setting a record for points scored. Since then, Ledesma has re-established himself in Catania's starting lineup and appeared in 30 matches during the 2010-11 campaign, bringing his total appearances to 74, helping the club achieve another 13th-place league finish and set a new record for points scored in Serie A over three consecutive seasons.