However, Beals and Hecht discovered in 1972 that, unlike Marfan's, CCA is caused by mutations to the fibrillin-2 (FBN2) gene rather than the fibrillin-1 (FBN1) gene.
Beals and Hecht's discovery in 1972 revealed that CCA is distinct from Marfan's syndrome, which is attributed to mutations in either the fibrillin-1 (FBN1) or fibrillin-2 (FBN2) genes.