More recently, cellular accumulation mediated by heparan sulfate proteoglycans and high-affinity glycosaminoglycan (GAG) binding indicates that cationic PPCs are intrinsically dual-function agents, acting by mechanisms discrete from the neutral, mononuclear agents.
More recently, cellular uptake mediated by heparan sulfate proteoglycans and high-affinity glycosaminoglycan (GAG) binding suggests that cationic polyproline peptides are intrinsically dual-functional agents, acting through mechanisms distinct from neutral, mononuclear agents.