When these two subunits interact in the plasma, the enzyme is activated and can act within the clotting cascade. rFXIII acts by inhibiting fibrinolysis factors which enzymatically cleave the fibrin matrix, leading to the ultimate formation of clots.
When these two subunits interact in the plasma, the enzyme is activated and can participate in the clotting cascade. rFXIII inhibits fibrinolysis factors by enzymatically cleaving the fibrin matrix, leading to clot formation.