For the bulk of its length, it runs parallel to Interstate 64 and approximately  north of it. Most of the route is two-lane undivided highway, with undivided multi-lane segments in the city of Princeton around the junction of U.S. Route 41, and through the city of Huntingburg as well as near English.
The majority of its length runs alongside Interstate 64, roughly north of it. The vast majority of the route is two-lane undivided highway, with divided multi-lane segments in Princeton at the intersection of U.S. Route 41, and through Huntingburg as well as near English.