Since NMDA receptors Dysfunction has been suggested as one of the promising hypotheses for the pathophysiology of schizophrenia, it has been shown that underexpression of this enzyme is an indicator, especially for the paranoid subtype.
The idea that NMDA receptor dysfunction may contribute to the pathogenesis of schizophrenia has been reinforced by research showing that decreased enzyme activity serves as a marker, especially for individuals with the paranoid form of the disorder.