SH 110 swings around the downtown area to the south and west by way of multiplexes with SH 64, SH 155, and US 69. After splitting with US 69, SH 110 leaves Tyler toward the northwest.
SH 110 curves around the downtown area to the south and west, passing through multiplexes alongside SH 64, SH 155, and US 69. After parting ways with US 69, SH 110 heads northwest from Tyler.