Iannetta made his MLB debut with the Rockies on August 27, 2006. Iannetta got his first career MLB hit that same day, off Jake Peavy of the San Diego Padres.
On August 27, 2006, Iannetta made his debut in Major League Baseball with the Rockies. He also achieved his first career hit on that same day, against Jake Peavy of the San Diego Padres.