Activation through the T cell receptor may play a role. It is found that memory T cells can sometimes react to novel antigens, potentially caused by intrinsic the diversity and breadth of the T cell receptor binding targets. These T cells could cross-react to environmental or resident antigens in our bodies (like bacteria in our gut) and proliferate.
The activation of T cells through their receptors may play a role in immune response, particularly when memory T cells react to novel antigens. This can occur due to the inherent diversity and breadth of T cell receptor binding targets, leading to cross-reactivity with environmental or resident antigens like bacteria in our gut.