Since the initial description of CFSE it has been used in thousands of immunological studies, an example of an early proliferation study in animals being described by Kurts et al. However, perhaps the most important CFSE investigations have been those demonstrating that many of the effector functions of lymphocytes, such as cytokine production by T lymphocytes, and antibody class switching by B cells, are division dependent.
Since its initial explanation, CFSE has been utilized in thousands of immunological studies, exemplified by an early proliferation study in animals described by Kurts et al. However, perhaps the most significant CFSE investigations have been those illustrating that many of the effector functions of lymphocytes, such as cytokine production by T lymphocytes and antibody class switching by B cells, are division-dependent.