CB signaling naturally modulates synaptic transmission and mediates psychoactivity, and synthetic cannabinoids mimic these same actions. Although the efficacy of Levonantradol is dependent on the level of GCPR activity, Full agonists like Levonantradol have the ability to activate GPCRs and convert Gα into a high affinity state for GTP or low affinity state for GDP.
CB signaling regulates synaptic transmission and psychoactivity, while synthetic cannabinoids mimic these effects. The effectiveness of Levonantradol is influenced by GCPR activity; full agonists like Levonantradol can activate GPCRs and alter the affinity of Gα to either high or low states for GTP or GDP.