On March 16 of 1542, Heredia departed for Antioquia to annex the territory to Cartagena. There Heredia was taken prisoner himself  by Sebastián de Belalcázar and sent to Panamá to stand trial for his attempts to seize control of Antioquia.
In 1542, Heredia left for Antioquia with the intention of incorporating it into Cartagena's territory. However, he was captured by Sebastián de Belalcázar and imprisoned in Panama before being put on trial for his actions.