Over time, these pigment cells can accumulate in the anterior chamber in such a way that they begin to clog the trabecular meshwork (the major site of aqueous humour drainage), which can in turn prevent the aqueous humour from draining and therefore increases the pressure inside the eye. A common finding in PDS are central, vertical corneal endothelial pigment deposits, known as Krukenberg spindle.
Over time, these pigment cells can accumulate in the anterior chamber to the point where they clog the trabecular meshwork (the major site of aqueous humor drainage), which can subsequently prevent the aqueous humor from draining and therefore increase pressure inside the eye. A common finding in PDS is central, vertical corneal endothelial pigment deposits, known as Krukenberg spindle.