It rises on the edge of the Belvedere subdivision on the outskirts of Newport, Delaware and flows southward along the western edge of that town. To the west of the run lies Bread and Cheese Island, cut off by a partly filled back channel between Hershey Run and Red Clay Creek.
The stream is situated at the edge of the Belvedere subdivision in Newport, Delaware, and travels south along the western boundary of the town.  To the west of the stream is Bread and Cheese Island, which is cut off from the main body by a partially filled channel between Hershey Run and Red Clay Creek.