The first portion of MD 350 was constructed between Salisbury and Mount Hermon as a state-aid road by 1915; this highway was improved and brought into the state highway system by 1919.
The initial stretch of Maryland Route 350 was constructed between Salisbury and Mount Hermon as a state-funded road by 1915, and it remained in that condition until it was upgraded and added to the state's highway network by 1919.