Euphemia married John Bruce of Cultmalindie (c. 1507 – March 1547), and had five children: Laurence Bruce, Robert Bruce (born c. 1536), Henry Bruce (born c. 1538), James Bruce (born c. 1540) and Euphamie Bruce (born c. 1542).
Euphemia's marriage to John Bruce resulted in the birth of five children: Laurence, Robert, Henry, James, and Euphamie.