Using ethyl (R)-4-(4-((6-oxo-5,6,6a,7,9,10-hexahydropyrido[3',2':5,6]pyrazino[2,1-c][1,4]thiazin-3-yl)methyl)piperazin-1-yl)benzoate to produce (R)-4-(4-((6-oxo-5,6,6a,7,9,10-hexahydropyrido[3',2':5,6]pyrazino[2,1-c][1,4]thiazin-3-yl)methyl)piperazin-1-yl)benzoic acid, please predict the condition, including solvent and agent in SMILES notation in json format like:

```JSON
{
    "solvent": [
        "CCN(CC)CC",
        "CCOC(C)=O"
    ],
    "agent": [
        "On1nnc2ccccc21",
        "C(=NC1CCCCC1)=NC1CCCCC1",
        "Cl"
    ]
}
```
