Using 1-(chloromethyl)-3-methylisoquinoline, tert-butyl (R)-(1-(1-(but-2-yn-1-yl)-5-methyl-4,7-dioxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl)piperidin-3-yl)carbamate to produce tert-butyl (R)-(1-(1-(but-2-yn-1-yl)-5-methyl-6-((3-methylisoquinolin-1-yl)methyl)-4,7-dioxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl)piperidin-3-yl)carbamate, please predict the condition, including solvent and agent in SMILES notation in json format like:

```JSON
{
    "solvent": [
        "CCN(CC)CC",
        "CCOC(C)=O"
    ],
    "agent": [
        "On1nnc2ccccc21",
        "C(=NC1CCCCC1)=NC1CCCCC1",
        "Cl"
    ]
}
```
