Using (R)-3-hydroxybutanoic acid, 5-(9-isobutyl-6-morpholino-8-(piperazin-1-yl)-9H-purin-2-yl)pyrimidin-2-amine to produce (R)-1-(4-(2-(2-aminopyrimidin-5-yl)-9-isobutyl-6-morpholino-9H-purin-8-yl)piperazin-1-yl)-3-hydroxybutan-1-one, please predict the condition, including solvent and agent in SMILES notation in json format like:

```JSON
{
    "solvent": [
        "CCN(CC)CC",
        "CCOC(C)=O"
    ],
    "agent": [
        "On1nnc2ccccc21",
        "C(=NC1CCCCC1)=NC1CCCCC1",
        "Cl"
    ]
}
```
