Fatal insomnia
Fatal familial insomnia (FFI) is an extremely rare autosomal dominant inherited prion disease of the brain. It is almost always caused by a mutation to the protein PrP, but can also develop spontaneously in patients with a non-inherited mutation variant called sporadic fatal insomnia (sFI). FFI has no known cure and involves progressively worsening insomnia, which leads to hallucinations, delirium, confusional states like that of dementia, and eventually, death. The average survival time for patients diagnosed with FFI after the onset of symptoms is 18 months.
Federal Bureau of Investigation
FBI Directors are appointed by the President of the United States. They must be confirmed by the United States Senate and serve a term of office of five years, with a maximum of ten years, if reappointed, unless they resign or are fired by the President before their term ends. J. Edgar Hoover, appointed by Calvin Coolidge in 1924, was by far the longest-serving director, serving until his death in 1972. In 1968, Congress passed legislation as part of the Omnibus Crime Control and Safe Streets Act Pub.L. 90–351, June 19, 1968, 82 Stat. 197 that specified a 10-year limit, a maximum of two 5-year terms, for future FBI Directors, as well as requiring Senate confirmation of appointees. As the incumbent, this legislation did not apply to Hoover, only to his successors. The current FBI Director is James B. Comey, who was appointed in 2013 by Barack Obama.
Sino-Tibetan relations during the Ming dynasty
In 1207, the Mongol ruler Genghis Khan (r. 1206–1227) conquered and subjugated the ethnic Tangut state of the Western Xia (1038–1227). In the same year, he established diplomatic relations with Tibet by sending envoys there. The conquest of the Western Xia alarmed Tibetan rulers, who decided to pay tribute to the Mongols. However, when they ceased to pay tribute after Genghis Khan's death, his successor Ögedei Khan (r. 1229–1241) launched an invasion into Tibet.
Rise of the Planet of the Apes
Andy Serkis as Caesar, a common chimpanzee whose intelligence is increased from inheriting ALZ - 112 from his mother during her pregnancy, and who is raised by Will for eight years.
Coat of arms of Charles V, Holy Roman Emperor
Charles V, Holy Roman Emperor, or Charles I of Spain, was the heir of four of Europe's leading royal houses. Charles was the first sole monarch of Spain, inheriting the kingdoms first united by his maternal grandparents, Isabella I of Castile and Ferdinand II of Aragon (the Catholic Monarchs). From his father, Philip I of Castile, he inherited the Burgundian Netherlands, which came from his paternal grandmother, Mary of Burgundy. Finally, on the death of his paternal grandfather, Maximilian I, Holy Roman Emperor, he inherited the Habsburg lands in Austria. His coat of arms, representing much of the land he inherited, is blazoned as follows:
Wilhelm Kettler
Born in Mitau in 1574, Wilhelm Kettler was the youngest son of Gotthard Kettler and his wife, Anna of Mecklenburg. After their father's death in 1587, Wilhelm and his brother Friedrich inherited the Duchy of Courland and Semigallia. The brothers divided the duchy between themselves, and Wilhelm ruled the Courland portion, with the seat in Kuldīga.
Roberto D'Ettorre Piazzoli
Born in Rome, Piazzoli began working for the Italian movie industry in the early 1960s as a cameraman, under the direction of Vittorio De Sica, Damiano Damiani, Marco Ferreri, Florestano Vancini, Mauro Bolognini, Dino Risi and Pasquale Festa Campanile.
Southern Europe
The period between 1815 and 1871 saw a large number of revolutionary attempts and independence wars. Balkan nations began to regain independence from the Ottoman Empire. Italy unified into a nation state. The capture of Rome in 1870 ended the Papal temporal power. Rivalry in a scramble for empires spread in what is known as The Age of Empire.
Jeanette Wohl
Jeanette Wohl (October 16, 1783, Frankfurt am Main – November 27, 1861, Paris) was a longtime friend and correspondent of Ludwig Börne. She inherited the rights to his literary works after his death and edited his works. She is buried at Père Lachaise Cemetery in Paris.
Roger I Trencavel
Roger I Trencavel, ("Roger I of Beziers"), (died 1150) was the eldest son of Bernard Ato IV, Viscount of Albi, Agde, Béziers, Carcassonne, Nîmes, and Razès. On his father's death in 1130 he inherited Albi, Carcassonne, and Razès, while his younger brother Raymond inherited Agde and Béziers and his youngest brother Bernard Ato V inherited Nîmes.
Solms-Laubach
Solms-Laubach was originally created as a partition of Solms-Lich. Solms-Laubach partitioned between itself and Solms-Sonnenwalde 1561; between itself, Solms-Baruth and Solms-Rödelheim 1607; and between itself and Solms-Sonnenwalde 1627. Solms-Laubach inherited Solms-Sonnenwalde in 1615. With the death of Count Charles Otto in 1676, it was inherited by Solms-Baruth and recreated as a partition in 1696. Solms-Laubach was mediatised to Hesse-Darmstadt in 1806.
Exit 67
The film was shot in French, English and Creole language and is set around Montreal's street gangs. In an interview with Montreal's La Presse columnist Rima Elkouri, director Jephté Bastien states that the death of his 16 years old nephew inspired him to make the film.
History of hospitals
The Normans brought their hospital system along when they conquered England in 1066. By merging with traditional land - tenure and customs, the new charitable houses became popular and were distinct from both English monasteries and French hospitals. They dispensed alms and some medicine, and were generously endowed by the nobility and gentry who counted on them for spiritual rewards after death.
Rookwood (novel)
Rookwood is a novel by William Harrison Ainsworth published in 1834. It is a historical and gothic romance that describes a dispute over the legitimate claim for the inheritance of Rookwood Place and the Rookwood family name.
Marion Koogler McNay
Marion Koogler McNay (7 February 1883 – 13 April 1950), was an American painter,art collector, and art teacher who inherited a substantial oil fortune upon the death of her parents She later willed her fortune to be used to establish San Antonio's first museum of modern art, which today bears her name.Inspired by Modern,Impressionism,and American Art she used her wealthy background to cultivate her eclectic art collection.McNay was able to design her San Antonio home after moving there in 1926.As soon as McNay moved to San Antonio she began buying and commissioning art pieces.The Spanish styled house was able to showcase a diverse amount of paintings including both American and European styled art. McNay favored Art made in the South Western American style.The fortune she inherited was able to fund her art collection which spanned over seven hundred art pieces by 1950, marking the year of her passing.San Antonio allowed McNay to have an expansive estate marking over 23 acres of land.The goal for McNay was to make her museum "a place of beauty with the comforts and warmth of a home."
Yoshiaki Tsutsumi
In 1964, the thirty-year-old Yoshiaki Tsutsumi inherited control of the Seibu Corporation upon the death of the company founder, his father Yasujirō Tsutsumi. Most observers had expected the designated successor to be his elder half-brother Seiji Tsutsumi. Seiji instead inherited the Seibu department stores, which he subsequently parlayed into the Credit Saison empire. Perceived rivalry between the two brothers' fiefdoms provided fodder for the popular press.
Vincenzo Scamozzi
Vincenzo Scamozzi (2 September 1548 – 7 August 1616) was an Italian architect and a writer on architecture, active mainly in Vicenza and Republic of Venice area in the second half of the 16th century. He was perhaps the most important figure there between Andrea Palladio, whose unfinished projects he inherited at Palladio's death in 1580, and Baldassarre Longhena, Scamozzi's only pupil.
History of genetics
In breeding experiments between 1856 and 1865, Gregor Mendel first traced inheritance patterns of certain traits in pea plants and showed that they obeyed simple statistical rules with some traits being dominant and others being recessive. These patterns of Mendelian inheritance demonstrated that application of statistics to inheritance could be highly useful; they also contradicted 19th century theories of blending inheritance as the traits remained discrete through multiple generation of hybridization.
The Inheritance (1976 film)
The Inheritance () is a 1976 Italian drama film directed by Mauro Bolognini. It was entered into the 1976 Cannes Film Festival, where Dominique Sanda won the award for Best Actress.
Ludwig Julius Caspar Mende
After graduation from the University of Göttingen (1801), he began work as a lecturer at the University of Greifswald. In 1814 he became an associate professor at Greifswald, followed by a full professorship during the following year. In 1823 he was appointed professor of forensic medicine and obstetrics at Göttingen, where until his death in 1832, he served as director of the department of obstetrics and gynecology.
What year saw the conquest of the city where the director of The Inheritance died?
The Inheritance >> director
Mauro Bolognini
#1 >> place of death
Rome
In what year was #2 conquered?
1870