Merck
Associate Principal Scientist, (Peptide/Bioconjugation)
Job Description

We are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines and vaccines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility, and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At our Company Research Labs, you will have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

Our Company is currently seeking an experienced peptide medicinal chemist, collaborator, and mentor to join the Discovery Chemistry Department at our West Point, PA site. The successful candidate will be responsible for the design, synthesis, purification and characterization of peptide or macrocycle drug candidates in target validation, hit-to-lead and lead optimization projects. In this role, the incumbent will engage in synthetic and medicinal chemistry problem solving and work with team members to drive progress. Experience is highly desired in the design and synthesis of bioconjugates with an understanding of protein chemistry, protein handling, purification and characterization.

He/She will collaborate across disciplines to analyze diverse data sets to build structure-activity relationships, influence experimental design and contribute to project strategy. Furthermore, the incumbent will be responsible for training and mentoring members of the team. As an Associate Principal Scientist, the candidate will have collaborative engagement with the external scientific community and make direct contributions to our Company’s external reputation. The successful candidate must also have excellent interpersonal, cross functional collaboration and communication skills.

To accomplish these goals, the successful candidate should have the following minimum qualifications, and required skills and experience:

Minimum Qualifications

Ph.D. in chemistry with a minimum of 4 years of industry experience in drug discovery or,M.S. in chemistry with a minimum of 7 years of industry experience in drug discovery or,B.S. in chemistry with a minimum of 9 years of industry experience in drug discovery

Required Skills And Experience

A minimum of 3 years’ experience in peptide synthesis, purification and analytical characterization including HPLC, MS and biophysical methodsExperience in communication, collaboration and leadership skills in a team environmentTrack record of scientific impact and driving project progress in the peptide/macrocycle modality fieldPublication record in the peptide/macrocycle literature

Desirable Skills

Experience with synthesis, purification, and characterization of peptide-protein and small molecule-protein lipidated conjugates.Expertise in protein analytical techniques, including gel electrophoresis, LC-MS, SEC-MALS, DLS, and CE.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separationpackage, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

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About

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status

Regular

Relocation:

Domestic

VISA Sponsorship

Yes

Travel Requirements

10%

Flexible Work Arrangements

Not Applicable

Shift

1st - Day

Valid Driving License

No

Hazardous Material(s)

N/A

Requisition ID:R290919
West Point, PA