Known risk factors include the following we may not be able to comply with all FDA postapproval commitments and requirements with respect to our products in a timely manner or at all success in preclinical and clinical trials especially if based on a small patient sample does not ensure that later clinical trials will be successful and the results of future research may not be consistent with past positive results or may fail to meet regulatory approval requirements for the safety and efficacy of product candidates if the actual number of patients suffering from the diseases we aim to treat is smaller than estimated our revenue and ability to achieve profitability may be adversely affected we may not be able to execute on our business plans including meeting our expected or planned regulatory milestones and timelines research and clinical development plans and bringing our product candidates to market for various reasons some of which may be outside of our control including possible limitations of company financial and other resources manufacturing limitations that may not be anticipated or resolved for in a timely manner the COVID19 pandemic and regulatory court or agency decisions such as decisions by the United States Patent and Trademark Office with respect to patents that cover our product candidates and those risks identified under the heading Risk Factors in our most recent Annual Report on Form 10K for the year ended December 31 2020 and most recent Quarterly Report on Form 10Q filed with the Securities and Exchange Commission SEC as well as other SEC filings made by the Company which you are encouraged to review