Various important factors could cause actual results or events to differ materially from the forward looking statements that Ascendis makes including the following dependence on third party manufacturers distributors and service providers for Ascendis products and product candidates unforeseen safety or efficacy results in its development programs or on market products unforeseen expenses related to commercialization of any approved Ascendis products expenses related to Ascendis development programs unforeseen selling general an d administrative expenses other research and development expenses and Ascendis business generally delays in the development of its programs related to manufacturing regulatory requirements speed of patient recruitment or other unforeseen delays Ascen dis ability to obtain additional funding if needed to support its business activities  the impact of international economic political legal compliance social and business factors including inflation and the effects on its business from the worldwi de COVID 19 pandemic and the ongoing conflict in the region surrounding Ukraine and Russia