
[BOR]
0: Safe
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[EOR]
[BOC]
I would approach her because this has serious implications. If I were in your shoes, I would try and speak to her in a very private place but ask casually (ex: "Hey sarah, can I talk to you for a second out back?"). If she says yes, I would pre-face my conversation with something along the lines of "I'm not asking for any of your personal business" and ask if she's aware of her changing skin color.

You'll get two reactions most likely..
1. Yes I am. Then reassure her that her life is none of your business and you're only bringing it up due to her personal health.
2. No I'm not. Stay Calm. Make a connection between your experiences with your father and your uncle and suggest she see's a physician or care provider. 

Good luck
[EOC]
