As Provincial of Mexico in 1535, he organized missions among three Indigenous groups stocks: the Nahua people, the Mixtec people, and the Zapotec people. He returned to Spain in 1549, and died in September of the same year at Valladolid. The Bishopric of Guatemala was tendered to Betanzos, but he declined it. In his classic work on the evangelization of Mexico, French scholar Robert Ricard called Betanzos zealous, ``an impetuous character, not well balanced, but not without intelligence'' with a passionate temper.
Robert Ricard
Betanzos