Her father Charles was a brother of Queen Charlotte of the UK and her mother Frederike was a granddaughter of Louis VIII, Landgrave of Hesse-Darmstadt. Her maternal grandmother, Landgravine Marie Louise of Hesse-Darmstadt, and her paternal first-cousin Princess Augusta Sophia of the United Kingdom served as sponsors at her baptism; her second given name came from Princess Augusta Sophia. At the time of her birth, Louise's father was not yet the ruler of Mecklenburg-Strelitz (he would not succeed his brother as Duke until 1794), and consequently she was not born in a court, but rather in a less formal home.
Augusta Sophia
Louise