*2.1. Materials*

Itraconazole (ITR) was purchased from Glentham Life Sciences Ltd. (Whitshire, UK). MeOH (HPLC grade) and terephthalic acid (TER) were purchased from Sigma-Aldrich (Arklow, Ireland). All other ingredients, such as solvents, solution and bu ffer components, as well as polymers, were kindly provided by Zentiva (Prague, Czech Republic).