**8. References**

Endometriosis and Infertility: The Role of Oxidative Stress 411

Cahill DJ, Harlow CR, Wardle PG. Pre-ovulatory granulosa cells of infertile women with

Calvin HI, Grosshans K, Blake EJ. Estimation and manipulation of glutathione levels in

Campos Petean C, Ferriani RA, Dos Reis RM, Dias de Moura M, Jordao AA, Jr., Navarro PA.

Carbone MC, Tatone C, Delle Monache S, Marci R, Caserta D, Colonna R et al. Antioxidant

Cetica PD, Pintos LN, Dalvit GC, Beconi MT. Antioxidant enzyme activity and oxidative stress in bovine oocyte in vitro maturation. IUBMB Life. 2001 Jan;51(1):57-64. Chaube SK, Prasad PV, Thakur SC, et al. Hydrogen peroxide modulates meiotic cell cycle

Cheesman KL, Cheesman SD, Chatterton Jr RT, Cohen MR. Alterations in progesterone

Combelles CM, Carabatsos MJ, Kumar TR, Matzuk MM, Albertini DF. Hormonal control of

Costa LO, Mendes MC, Ferriani RA, Moura MD, Reis RM, Silva de Sá MF. Estradiol and

de Matos DG, Furnus CC, Moses DF. Glutathione synthesis during in vitro maturation of bovine oocytes: role of cumulus cells. Biol Reprod. 1997 Dec;57(6):1420-5. de Matos DG, Furnus CC. The importance of having high glutathione (GSH) level after

De Santis L, Cino I, Rabellotti E, Calzi F, Persico P, Borini A et al. Polar body morphology

Díaz I, Navarro J, Blasco L, et al. Impact of stage III-IV endometriosis on recipients of sibling

Erickson GF, Garzo VG, Magoffin DA. Insulin-like growth factor-I regulates aromatase

Fernando S, Breheny S, Jaques AM, Halliday JL, Baker G, Healy D. Preterm birth, ovarian endometriomata, and assisted reproduction technologies. Fertil Steril 2008. Ferreira EM, Vireque AA, Adona PR, Meirelles FV, Ferriani RA, Navarro PA. Cytoplasmic

cysteine and cystine. Theriogenology. 2000 Feb;53(3):761-71.

oocytes: matched case-control study. Fertil Steril. 2000;74(1):31-4.

2003 Feb;49(2):66-9.

1983;40(5):590–5.

2004 Oct 26.

2005;11:36-42.

1989 Oct;69(4):716-24.

Dev. 2004 Nov;69(3):347-55.

the fertilized egg. Gamete Res 1986.

changes. Mol Hum Reprod 2003;9:639-43.

cultured in vitro. Apoptosis. 2005; 10(4):863–874.

pilot study. Fertil Steril 2008.

endometriosis are less sensitive to luteinizing hormone. Am J Reprod Immunol.

prepuberal mouse ovaries and ova: relevance to sperm nucleus transformation in

Lipid peroxidation and vitamin E in serum and follicular fluid of infertile women with peritoneal endometriosis submitted to controlled ovarian hyperstimulation: a

enzymatic defences in human follicular fluid: characterization and age-dependent

and induces morphological features characteristic of apoptosis in rat oocytes

metabolism and luteal function in infertile women with endometriosis. Fertil Steril

somatic cell oocyte interactions during ovarian follicle development. Mol Reprod

testosterone concentrations in follicular fluid as criteria to discriminate between mature and immature oocytes. Braz J Med Biol Res. 2004 Nov;37(11):1747-55. Epub

bovine in vitro maturation on embryo development effect of beta-mercaptoethanol,

and spindle imaging as predictors of oocyte quality. Reprod Biomed Online

activity in human granulosa and granulosa luteal cells. J Clin Endocrinol Metab.

maturation of bovine oocytes: structural and biochemical modifications and

Al-Fadhli R, Kelly SM, Tulandi T, Tanr SL. Effects of different stages of endometriosis on the outcome of in vitro fertilization. J Obstet Gynaecol Can 2006;28:888-91. Ali AA, Bilodeau JF, Sirard MA. Antioxidant requirements for bovine oocytes varies during

Alpay Z, Saed GM, Diamond MP. Female infertility and free radicals: potential role in adhesions and endometriosis. J Soc Gynecol Investig. 2006; 13(6):390-8. Amaral VF, Bydlowski SP, Peranovich TC, Navarro PA, Subbiah MT, Ferriani RA. Lipid

endometriosis. Eur J Obstet Gynecol Reprod Biol. 2005 Mar 1;119(1):72-5. Andrade AZ, Rodrigues JK, Dib LA, Romão GS, Ferriani RA, Jordão Junior AA, Navarro

Armstrong DT. Effects of maternal age on oocyte developmental competence.

Assou S, Anahory T, Pantesco V, Carrour1 T, Pellestor F, Klein B, Reyftmann L, Dechaud H,

Assou S, Haouzi D, Mahmoud K, Aouacheria A, Guillemin Y, Pantesco V, Rème T, Dechaud

Bar-Ami S. Increasing progesterone secretion and 3 beta-hydroxysteroid dehydrogenase

Barcelos ID, Vieira RC, Ferreira EM, Araújo MC, Martins W de P, Ferriani RA, Navarro PA.

Barnhart K, Dungsmoor-Su R, Coutifaris C. Effect of endometriosis on in vitro fertilization.

Bornoden W. Antioxidant nutrients and protection from free radicals. In: Kotsonis FN,

Brizek CL, Schlaff S, Pellegrini VA, Frank JB, Worrilow KC. Increased incidence of aberrant

Bulun SE, Ping Yin YHC, Imir G, et al. Progesterone resistance in endometriosis: link to failure to metabolize estradiol. Mol Cell Endocrinol 2006;248:94–103.

ovarian stimulation. Rev Bras Ginecol Obstet. 2008 Aug;30(8):413-9. Barcelos ID, Vieira RC, Ferreira EM, Martins WP, Ferriani RA, Navarro PA. Comparative

Bras Ginecol Obstet. 2010 Jun;32(6):279-85.

profile Hum Reprod. 2006 July ; 21(7): 1705–1719.

Steril. 2009 Nov;92(5):1749-52. Epub 2009 Jun 12.

endometriosis. J Assist Reprod Genet 1995;12:106-12.

Babior BM. Superoxide: a two-edged sword. Bras J Biol Res. 1997; 30(2): 141-55.

Theriogenology. 2001; 55(6):1303-22.

Hum Reprod. 2008 ;14(12):711-9.

1994 Dec;51(5-6):299-305.

Fertil Steril. 2002; 77(6): 148-55.

48.

4):939-49.

in vitro maturation, fertilization and development. Theriogenology. 2003 Feb;59(3-

peroxidation in the peritoneal fluid of infertile women with peritoneal

PA. Serum markers of oxidative stress in infertile women with endometriosis. Rev

De Vos J, Hamamah S. The human cumulus-oocyte complex gene-expression

H, De Vos J, Hamamah S. A non-invasive test for assessing embryo potential by gene expression profiles of human cumulus cells: a proof of concept study. Mol

activity of human cumulus cells and granulosa-lutein cells concurrent with successful fertilization of the corresponding oocyte. J Steroid Biochem Mol Biol.

Meiotic abnormalities of oocytes from patients with endometriosis submitted to

analysis of the spindle and chromosome configurations of in vitro-matured oocytes from patients with endometriosis and from control subjects: a pilot study. Fertil

Mackey M, Hjelle JJ (eds). Nutritional Toxicolgy. New York, Raven Press 1994; 19-

morphological phenotypes in human embryogenesis--an association with

Endometriosis and Infertility: The Role of Oxidative Stress 413

Haouzi D, Hamamah S. Pertinence of Apoptosis Markers for the Improvement of In Vitro

Harlow CR, Cahill DJ, Maile LA, et al. Reduced preovulatory granulosa cell steroidogenesis in women with endometriosis. J Clin Endocrinol Metab 1996;81:426–9. Ho YS, Magnenat JL, Bronson RT, Cao J, Gargano M, Sugawara M, Funk CD: Mice deficient

Holtz G, Williamson HO, Mathur RS, Landgrebe SC, Moore EE. Luteinized unruptured

Hu Y, Betzendahl I, Cortvrindt R, Smitz J, Eichenlaub-Ritter U. Effects of low O2 and ageing

Hutt KJ, Albertini DF. An oocentric view of folliculogenesis and embryogenesis. Reprod

Jana SK, K NB, Chattopadhyay R, Chakravarty B, Chaudhury K. Upper control limit of

Jancar N, Kopitar AN, Ihan A, Virant Klun I, Bokal EV. Effect of apoptosis and reactive

blastocyst development. J Assist Reprod Genet. 2007 Feb-Mar;24(2-3):91-7. Jozwik M, Wolczynski S, Szamatowicz M. Oxidative stress markers in preovulatory

Katsoff B, Check JH, Davies E, Wilson C. Evaluation of the effect of endometriosis on oocyte

Kaya H, Oral B. Effect of ovarian involvement on the frequency of luteinized unruptured

Kim NH, Chung HM, Cha KY, Chung KS. Microtubule and microfilament organization in

Kumbak B, Kahraman S, Karlikaya G, Lacin S, Guney A. In vitro fertilization in

LaPolt PS, Hong LS. Inhibitory effects of superoxide dismutase and cyclic guanosine 30,50-

Liu L, Trimarchi JR, Navarro P, Blasco MA, Keefe DL. Oxidative stress contributes to

Mandelbaum J, Anastasiou O, Levy R, Guerin JF, de Larouziere V, Antoine JM. Effects of

Mansour G, Abdelrazik H, Sharma RK, Radwan E, Falcone T, Agarwal A. L-carnitine

follicle in endometriosis. Gynecol Obstet Invest 1999;48(2):123–6.

maturing human oocytes. Hum Reprod 1998;13:2217-22.

ovarian cysts. Gynecol Obstet Invest 2008;65:212-6.

in cellular glutathione peroxidase develop normally and show no increased

follicle syndrome in mild endometriosis assessment with biochemical parameters. J

on spindles and chromosomes in mouse oocytes from pre-antral follicle culture.

reactive oxygen species in follicular fluid beyond which viable embryo formation is

oxygen species production in human granulosa cells on oocyte fertilization and

quality and endometrial environment by comparison of donor and recipient outcomes following embryo transfer in a shared oocyte program. Clin Exp Obstet

normoresponder patients with endometriomas: comparison with basal simple

monophosphate on estrogen production in cultured rat granulosa cells.

arsenic-induced telomere attrition, chromosome instability, and apoptosis. J Biol

cryopreservation on the meiotic spindle of human oocytes. Eur J Obstet Gynecol

supplementation reduces oocyte cytoskeleton damage and embryo apoptosis

Fertilization (IVF). Curr Med Chem. 2009;16(15):1905-16.

sensitivity to hyperoxia. J Biol Chem 1997, 272:16644-16651.

Reprod Med 1985;30(9):643–5.

Hum Reprod 2001;16:737-48.

Gynecol. 2006; 33(4):201-2.

Endocrinology 1995;136:5533–9.

Reprod Biol 2004;113 Suppl 1:S17-23.

Chem 2003;278:31998-2004.

Biomed Online. 2007 Jun;14(6):758-64.

not favorable. Reprod Toxicol. 2010 Jul;29(4):447-51.

follicular fluid in humans. Mol Hum Reprod 1999;5:409-13.

acquisition of developmental competence. Theriogenology. 2009 Mar 15;71(5):836- 48. Epub 2009 Jan 3. Review.

Földesi I, Breckwoldt M, Neulen J. Oestradiol production by luteinized human granulosa

Fujii J, Iuchi Y, Okada F. Fundamental roles of reactive oxygen species and protective

Furger C, Cronier L, Poirot C, Pouchelet M. Human granulosa cells in culture exhibit

Furnus CC, de Matos DG, Moses DF. Cumulus expansion during in vitro maturation of

subsequent embryo development. Mol Reprod Dev. 1998 Sep;51(1):76-83 García-Velasco J, Arici A. Is endometrium or the oocyte/embryo affected in endometriosis?

Garrido N, Navarro J, Garcia-Velasco J, Remohi J, Pellice A, Simon C. The endometrium

Garrido N, Navarro J, Remohi J, Simon C, Pellicer A. Follicular hormonal environment and embryo quality in women with endometriosis. Hum Reprod Update 2000;6:67-74. Gomes FM, Navarro PA, de Abreu LG, Ferriani RA, dos Reis RM, de Moura MD. Effect of

Guérin P, El Mouatassim S, Ménézo Y. Oxidative stress and protection against reactive

Guet P, Royère D, Paris A, Lansac J, Driancourt MA. Aromatase activity of human granulosa

Gupta S, Agarwal A, Kraicir N, et al. Role of oxidative stress in endometriosis. Reprod

Halliwell B. Free radicals, antioxidants and human disease: curiosity, cause or consequence?

Hamamah S, Matha V, Berthenet C, Anahory T, Loup V, Dechaud H, Hedon B, Fernandez

Hamel M, Dufort I, Robert C, Gravel C, Leveille MC, Leader A, Sirard MA. Identification of

Hansen JC, Deguchi Y: Selenium and fertility in animals and man – a review. Acta Vet

competent oocytes. Hum Reprod. 2008;23(5):1118-27.

48. Epub 2009 Jan 3. Review.

Aug;2(8):541-8.

2002;8:95-103.

Update. 2001; 7(2):175-89.

Biomed Online. 2006; 13(1):126-34.

Lancet. 1994; 344(8924):721-4.

Online. 2006;13(6):807-14.

Scand 1996, 37:19-30.

May;14(5):1182-9.

hormone. Hum Reprod. 1998 Jun;13(6):1455-60.

Hum Reprod. 1999; 14 (Suppl. 2):77-89.

acquisition of developmental competence. Theriogenology. 2009 Mar 15;71(5):836-

cells: evidence of the stimulatory action of recombinant human follicle stimulating

mechanisms in the female reproductive system. Reprod Biol Endocrinol. 2005; 3:43.

functional cyclic AMP-regulated gap junctions. Mol Hum Reprod. 1996

bovine oocytes: relationship with intracellular glutathione level and its role on

versus embryonic quality in endometriosis-related infertility. Hum Reprod Update

peritoneal fluid from patients with minimal/mild endometriosis on progesterone release by human granulosa-lutein cells obtained from infertile patients without endometriosis: a pilot study. Eur J Obstet Gynecol Reprod Biol. 2008;138(1):60-5. González F, Rote NS, Minium J, Kirwan JP. Reactive oxygen species-induced oxidative

stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome. J Clin Endocrinol Metab. 2006 Jan;91(1):336-40. Epub 2005 Oct 25.

oxygen species in the pre-implantation embryo and its surroundings. Hum Reprod

cells in vitro: effects of gonadotrophins and follicular fluid. Hum Reprod. 1999

A, Lamb N. Comparative protein expression profiling in human cumulus cells in relation to oocyte fertilization and ovarian stimulation protocol. Reprod Biomed

differentially expressed markers in human follicular cells associated with

Endometriosis and Infertility: The Role of Oxidative Stress 415

Silva AL, Abreu LG, Rosa-e-Silva AC, Ferriani RA, Silva-de-Sá MF. Leuprolide acetate

Speroff L, Fritz MA. Regulation of the Menstrual Cycle. In: Speroff L & Fritz MA. Clinical

Szczepanska M, Kozlik J, Skrzypczak J, et al. Oxidative stress may be a piece in the

Tanghe S, Van Soom A, Nauwynck H, Coryn M, de Kruif A. Minireview: Functions of the

Tatemoto H, Sakurai N, Muto N. Protection of porcine oocytes against apoptotic cell death

Tesfaye D, Ghanem N, Carter F, Fair T, Sirard MA, Hoelker M, Schellander K, Lonergan P

Thomas FH, Vanderhyden BC. Oocyte-granulosa cell interactions during mouse follicular

Tsai-Turton M, Luderer U. Opposing effects of glutathione depletion and follicle-

Van Blerkom J, Davis P. Differential effects of repeated ovarian stimulation on cytoplasmic

Van Kaam KJ, Romano A, Schouten JP, Dunselman GA, Groothuis PG. Progesterone

Van Langendonckt A, Casanas-Roux F, Donnez J. Oxidative stress and peritoneal

Verit FF, Erel O, Kocyigit A, Association of increased total antioxidant capacity and

Volarcik K, Sheean L, Goldfarb J, Woods L, Abdul-Karim FW, Hunt P. The meiotic

Wang WH, Keefe DL. Prediction of chromosome misalignment among in vitro matured

Wardle PG, Mitchell JD, McLaughlin EA, Ray BD, McDermott A, Hull MG. Endometriosis

matured either in vivo or in vitro. Reprod Fertil Dev. 2009;21(3):451-61. Tetsuka M, Hillier SG. Differential regulation of aromatase and androgen receptor in

granulosa cells. J Steroid Biochem Mol Biol. 1997 Apr;61(3-6):233-9.

preovulatory rat follicles. Endocrinology 2006;147:1224–36.

infiltrating endometriosis. Hum Reprod 2007;22(1):129–35.

endometriosis. Fertil Steril. 2002; 77(5):861-70.

unexplained infertility. Lancet 1985; 2(8449):236-9.

endometriosis puzzle. Fertil Steril. 2003; 79(6):1288-93.

Aug 26.

Wilkins p. 187-231: 2005.

Reprod Dev. 2002 Mar;61(3):414-24.

Reprod Biol Endocrinol. 2006 Apr 12;4:19.

vitro. Hum Reprod 2001;16:757-64.

Hum Reprod 1998;13:154-60.

polycystic

Reprod. 2000 Sep;63(3):805-10.

reduces both in vivo and in vitro ovarian steroidogenesis in infertile women undergoing assisted reproduction. Steroids. 2008 Dec 22;73(14):1475-84. Epub 2008

Gynecologic Endocrinology and Infertility. 7 ed. Baltimore: Lippincott Williams &

cumulus oophorus during oocyte maturation, ovulation, and fertilization. Mol

caused by oxidative stress during In vitro maturation: role of cumulus cells. Biol

Gene expression profile of cumulus cells derived from cumulus-oocyte complexes

development: regulation of kit ligand expression and its role in oocyte growth.

stimulating hormone on reactive oxygen species and apoptosis in cultured

and spindle organization in metaphase II mouse oocytes matured in vivo and in

receptor polymorphism +331G/A is associated with a decreased risk of deep

anovulation in nonobese infertile patients with clomiphene citrate–resistant

competence of in-vitro matured human oocytes is influenced by donor age: evidence that folliculogenesis is compromised in the reproductively aged ovary.

human oocytes by spindle imaging with the PolScope. Fertil Steril 2002;78:1077-81.

and ovulatory disorder: reduced fertilization in vitro compared with tubal and

induced by incubation in peritoneal fluid from patients with endometriosis. Fertil Steril. 91(5 Suppl):2079-86, 2009

Matos L, Stevenson D, Gomes F, Silva-Carvalho JL, Almeida H. Superoxide dismutase

Murray AA, Molinek MD, Baker SJ, Kojima FN, Smith MF, Hillier SG, et al. Role of ascorbic

Navarro PA, Liu L, Ferriani RA, Keefe DL. Arsenite induces aberrations in meiosis that can

Navarro PA, Liu L, Keefe DL. In vivo effects of arsenite on meiosis, preimplantation development, and apoptosis in the mouse. Biol Reprod. 2004; 70(4):980-5. Navarro PA, Liu L, Trimarchi JR, et al. Noninvasive imaging of spindle dynamics during mammalian oocyte activation. Fertil Steril. 2005; 83(Suppl 1):1197-205. Paszkowski T, Traub AI, Robinson SY, McMaster D: Selenium dependent glutathione peroxidase activity in human follicular fluid. Clin Chim Acta 1995, 236:173-180). Pellicer A, Navarro J, Bosch E, Garrido N, Garcia-Velasco JA, Remohí J, Simón C.

Pellicer A, Oliveira N, Ruiz A, Remohi J, Simon C. Exploring the mechanism(s) of

implantation in assisted reproduction. Hum Reprod 1995;10 Suppl 2:91-7. Pellicer A, Valbuena D, Bauset C, et al. The follicular environment in stimulated cycles of

Perreault SD, Barbee RR, Slott VI. Importance of glutathione in the acquisition and

Perreault SD, Wolff RA, Zirkin BR. The role of disulfide bond reduction during mammalian sperm nuclear decondensation in vivo. Dev Biol. 1984 Jan;101(1):160-7. Revised American Society for Reproductive Medicine classification of endometriosis: 1996.

Sabatini L, Wilson C, Lower A, Al-Shawaf T, Grudzinskas JG Superoxide dismutase activity

Saracoglu OF, Aksel S, Yeoman RR,Wiebe RH. Endometrial estradiol and progesterone

Seino T, Saito H, Kaneko T, Takahashi T, Kawachiya S, Kurachi H. Eight-hydroxy-2'-

undergoing in vitro fertilization. Fertil Steril 1999, 72:1027-1034.].

Fertil Steril. 1997 May;67(5):817-21. [No authors listed]

Meister A. Selective modification of glutathione metabolism. Science 1983; 220:472-477. Murphy AA, Santanam N, Parthasarathy S. Endometriosis: A disease of oxidative stress?

Steril. 91(5 Suppl):2079-86, 2009

Vol.15, No.7 pp. 411–419, 2009

vitro. Reproduction 2001;121:89–96.

2001 Sep;943:122-30. Review.

Dev Biol. 1988 Jan;125(1):181-6.

Suppl 1:1187-94.

1998;69:1135–41.

1985;43(6):851–5.

Jun;77(6):1184-90.

Semin Reprod Endocrinol. 1998; 16(4):263-73.

induced by incubation in peritoneal fluid from patients with endometriosis. Fertil

expression in human cumulus oophorus cells Molecular Human Reproduction,

acid in promoting follicle integrity and survival in intact mouse ovarian follicles in

be prevented by coadministration of N-acetylcysteine in mice. Fertil Steril 2006;85

Endometrial quality in infertile women with endometriosis. Ann N Y Acad Sci.

endometriosis-related infertility: an analysis of embryo development and

women with endometriosis: esteroid levels and embryo quality. Fertil Steril

maintenance of sperm nuclear decondensing activity in maturing hamster oocytes. .

in human follicular fluid after controlled ovarian hyperstimulation in women

receptors in patients with luteal phase defects and endometriosis. Fertil Steril

deoxyguanosine in granulosa cells is correlated with the quality of oocytes and embryos in an in vitro fertilization-embryo transfer program. Fertil Steril. 2002

**Section 4**

**Diagnosis and Treatment**


2.4.6. Solubility Studies

The solubility of KET from the crystalline acid form (KETH) and ZnAl-KET was measured in water, and the samples were prepared as follows: an excess of the sample (10 mg KETH and 24.10 mg of ZnAl-KET corresponding to 10 mg of KETH) was dispersed in 10 mL of ultrapure water under magnetic stirring (600 rpm) at 25 ◦C until equilibrium was achieved (48 h). The samples were filtered through a 0.45 μm nylon filter, suitably diluted, and analyzed by UV-VIS spectrophotometry.


*3.1. Study Participants*

The number of subjects participating in this study was 87. There were 41 men and 46 women who were all 90 years old. Adequate mount samples for pyrosequencing analysis were not obtained from one man and one woman.


*Edited by Marie Alricsson*

Work-related musculoskeletal disorders are a significant problem throughout the world. The work environment has undergone rapid changes in recent years. With increasing number of workers being tied to man, machine systems, susceptibility to constrained postures, visual strain and mental and physical stresses have increased. This book is a collaboration among many clinicians and researchers and a small step in addressing these issues by discussing various aspects of musculoskeletal disorders from different professions, researchers and countries.

ISBN 978-953-51-0485-8

Musculoskeletal Disorder

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## Musculoskeletal Disorder

*Edited by Marie Alricsson*

**MUSCULOSKELETAL**

**DISORDER**

Edited by **Marie Alricsson**

## **MUSCULOSKELETAL DISORDER**

Edited by **Marie Alricsson**

http://dx.doi.org/10.5772/2547 Edited by Marie Alricsson

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Bang Nguyen, Newman Lau, Rita Sjostrom, Marie Alricsson, Mauro Carino, Carsten Tjell

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