*Metabolite Multiprobiotic Formulas for Microbial Health DOI: http://dx.doi.org/10.5772/intechopen.86449*

*Oral Health by Using Probiotic Products*

and antibiotics)

mosaics of antimicrobials)

functioning mucosal organs

(using upon therapy)

gies of therapy)

**4. Conclusion**

of non-culturable microorganisms).

*3.7.2 Intercellular and cell-metabolite technologies*

(constructing symbiotic consortia, balanced vaccines)

• For Gram-positive bacteria (opportunistic and pathogenic)

microassay (reactions of mono- and mixed biofilms)

• Leader strains and species within MB (evaluation of temporary

• The use of recognizing metabolites instead of cells or in combinations with cells for support of feeble living and antibiotic-sensitive cultures (also in cases

• Constructing balanced supporting MB of probiotic cell-metabolite consortia

• Sensor microbial systems of MB (revealing and using key antagonistic systems) Directed assembling of cytokine-cell gradients: reversible functional (1–2 days) or late irreversible conserved and partially inactivated (4–6 weeks), as in cases of biofilms containing erythrocytes—in microassay (evaluation of protection and degradation of human cells in the presence of pathogens)

• Biofilm forming as ranked quantitative and qualitative, early and delayed—in

• Species-dependent redistribution of antagonistic MB (prediction of mutual influence between species and strains of probiotics, opportunistic microbes,

MB-destabilizing strains in coexistent antagonistic microbial populations)

• Destabilization and synchronization of MB by recognizing components of cultures for increasing future selective synergistic action of antimicrobials and stress factors (increase of early and late suppression of pathogens) Microecological interniche early and delayed landscape relationships in cases of solid-phased and suspension microbial massifs, for microanalysis (evaluation of opportunistic microbes and MB as communicative bodies opposed to

• Construction of active (involving probiotic leaders) and stabilizing (speciesdependent and resistant to antibiotics, probiotic-like supporting MB) consortia

• Strain-phenotyping dysbiotic MB using lectin systems (revealing early changes in patient MB in the presence of lectins of MB, for development of new strate-

• LS of probiotic consortia (directions of consortium formula actions can be predicted by constructing) as ingredients of functional food to support resistant

The data presented consider aspects of constructing probiotic multistrain intra- and inter-genus Gram-positive bacterial metabolites on examples of bifidobacteria and lactobacilli of the human gut origin. Algorithms of creation

**86**

of 4- and 7-code MP formulas are presented and argued. It is of importance to consider LSSM and their GC as a new perspective protective basis/scaffold factor influencing and supporting human interactome, involving biotope infrastructures, signaling, and anti-infectious actions as well as cofunctioning together with other protective human systems [17, 42]. Results support the use of pro-/symbiotic LS as assistant-coordinated metabolomic agents; carriers for delivery and releasing GC, metabiotics (including simulators of cell surface patterns of opportunistic microorganisms), prebiotics, therapeutics, and antigens (for cofunctioning to antibodies); and reserves for decoration elements that support stabile functioning landscapes of the human cell surfaces and mucosal tissues. Probiotic lectins (interacting with synthetic GC simulators) are important for screening, typing, and selection of useful strains and their consortia supporting organs. The proposed LSSM-containing preparations promise LSSM using a soft adaptive multidirected network synergistically acting together with other protectors (also in conditions of the absence of oxygen [involving oxidative stress and forming of covalently bound by-products] within biotope). Variants of multipro-/sym-/synbiotics constructed can be perspective for prophylaxis for individuals and contingents as well as for supporting treatments of patients (before and postoperative period, during chemotherapy, etc.). Approaches developed are useful in study of interniche relationships of extended set of Gram-positive and fungal microorganisms in mono- and mixed cultures. Procedures can be applied in different fields of clinical microbiology and medical biotechnology.