*5.2.1. Local tumour spread: T*

In 88 patients undergoing only surgical treatment, increasing GPS was associated with higher T and resection line status [96]. In a recent meta-analysis, association between high GPS and high TNM stage was found. Although the association with lymph node metastases (OR 4.60; 95% CI = 3.23–6.56) was significant, there was no association with T [106].