*3.5. Meroterpenes*

3.5.1. Alisiaquinones and Alisiaquinol

Alisiaquinones A–C (**96**–**98**) and alisiaquinol (**99**) (Figure 24) are meroterpenes that were isolated in 2008 from a New Caledonian deep-water sponge [90]. They display mild antimalarial activity, but the high level of toxicity (100% and 80% mortality, respectively) shown in in vivo assays limited their interest as antimalarial agents. Nevertheless, their structure can be an inspiration for the development of related structures towards novel antimalarial drugs.

**Figure 24.** Structure of alisiaquinones A–C (**96–98**) and alisiaquinol (**99**).