Meet the editors

Dr. Amit Agrawal completed his MCh in Neurosurgery at the National Institute of Mental Health and Neurosciences, Bangalore, India, and is now a member of many field-related societies including the World Federation of Neurological Societies, Congress of Neurological Societies, American Association of Neurological Surgeons, International Stroke Society, World Association of Medical Editors, Indian Society of Neuro-oncol-

ogy, and World Endoscopic Spine Society.

Dr. Daulat Singh obtained his MD from Gandhi Medical College, India. He has vast experience in managing oncology clinical practice. He worked closely to establish the Radiation Oncology Department, including helping to install a dual-energy linear accelerator, as well as the tele-radiation therapy and chemotherapy unit at Government Doon Medical College, India.

## Contents

Preface

Glioblastoma multiforme (GBM) has a complex pathogenesis and mutates and alters several key cellular pathways involving cell proliferation, cell migration, and tumor vessel angiogenesis. GBM is known for its rapidly progressive nature. It is a debilitating disease associated with limited response to therapies, poor outcomes, and a very short median overall survival. The diagnosis and management of glioblastomas require multimodal strategies and a multidisciplinary approach. Treatment may involve surgical resection, radiation therapy, and chemotherapy. Significant advances have been made to understand the pathology of GBM, particularly molecular mechanisms and targets for immunotherapy. Recent advances in genetic testing have improved our understanding of the glioblastoma category of brain tumors and have helped us decide on management and follow-up strategies. This book discusses the management of glioblastoma, isocitrate dehydrogenases (IDH)-mutated gliomas, evolving molecular diagnosis strategies, management of lesions involving the corpus callosum, glycan and glycosylation as

potential targets for designing therapies, systemic treatment in glioblastoma, the potential

glycosides in disease evaluation and treatment, management of glioblastoma in the elderly, research related to immunization with autologous IFN-D, and the use of canine glioma as a model for human glioblastoma. This book is a useful resource for understanding and exploring current advances in GBM treatment, including the identification of the molecular characteristics that determine the malignant phenotype, which t may further

> **Amit Agrawal** Professor,

> > Bhopal, India

Dehradun, India

**Daulat Singh Kunwar**

Department of Neurosurgery,

All India Institute of Medical Sciences,

Government Doon Medical College,

Department of Radiotherapy and Clinical Oncology,

utility of lipid-based nano-drug carriers, the role of cancer stem cells and cardiac

help to develop effective management strategies including immunotherapy.