**5. Conclusions**

Concluding, we can state that it was received the most complete up to now quantum map of the biologically-important conformationally-tautomeric transitions of the classical AT/AU nucleobase pair, which enable to classify it as a *quantum choreography with all further going consequences*. But it is not a pursuit of a new term, but rather an attempt to realize the molecular logic of the quantum evolution at its initial stages, when it was formed its behavior, which is evolutionary programmed in its electronic structure.

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**13**

For the first time, it was shown for the classical AT DNA base pair that prototropic tautomerism of the DNA bases is responsible both for the origin, as well as for the supporting of the unusual local structures in the constitution of DNA and in complexes with proteins and small biomolecules. Moreover, prototropic tautomerism of the classical AT DNA base pair significantly expands its conformational possibilities and its impact on the biological importance.

It is connected with the fact that presented mechanisms of the tautomerization are assisted by the significant changing of the geometry of the tautomerizing base pair. This means that they are conformationally-tautomeric transitions by their essence.

This conclusion is confirmed by the structural bioinformatics. Thus, it was identified hundredth of the structures containing tautomers of the DNA bases. This fact points that all described exited conformationally-tautomeric states of the AT and AU nucleobase pairs, corresponding to local minima, are real structures.


**5. Conclusions**

Our present work has characterized the detoxification gene families of *T. yunanensis* by transcriptome, together with bioinformatics-based analyses and molecular strategies of qPCR. Our study first lead to the identification of 113 genes associated with detoxification, with as many as 51 CYPs. Further, expression profile studies provided reference data for these genes to explore their potential roles in the detoxification of plant secondary metabolites. Together, this study has complemented the information of detoxification gene families in *T. yunanensis* and will allow for target experiments to screen potential attractants or repellents and to develop novel pest control strategies for controlling this beetle and protect the balance of the forest ecosystem.

**Supplementary Materials:** The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/10.3390/d14010023/s1, Table S1: The primers designed for qPCR analysis; Table S2: Protein sequence of Tomicus yunnanensis.

**Author Contributions:** Conceptualization, W.L. and N.Z.; methodology, B.Y. and N.L.; software, J.Z. and Z.L.; validation, W.L., S.Z. and N.Z.; formal analysis, N.L.; investigation, J.Z. and Z.L.; resources, W.L. and B.Y.; data curation, J.Y.; writing—original draft preparation, W.L.; writing—review and editing, W.L. and N.Z.; visualization, N.Z.; supervision, N.Z.; project administration, N.Z.; funding acquisition, N.Z. All authors have read and agreed to the published version of the manuscript.

**Funding:** The research was supported by the National Natural Science Foundation of China (31760210), the Science Research Foundation of Yunnan Provincial Department of Education Project (2021Y269), and Key Project of Yunnan Applied Basic Research Program (grand No.202101AS070009; 2018FG001-010).

**Institutional Review Board Statement:** Not applicable.

**Data Availability Statement:** All Data are provided within the paper and supplementary material.

**Conflicts of Interest:** All the authors declare that they have no conflict of interest.