**Author details**

M. Arnal-Pastor1 , J. C. Chachques2 , M. Monleón Pradas1,3\* and A. Vallés-Lluch1

\*Address all correspondence to<EMAIL_ADDRESS>
1 Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Cno. de Vera s/n, Valencia, Spain

2 Department of Cardiovascular Surgery, Laboratory of Biosurgical Research, Georges Pom‐ pidou European Hospital, Paris, France

3 Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Valencia, Spain

### **References**

**References**

304 Regenerative Medicine and Tissue Engineering

1999; 118: 375-82.

j.ejcts.2006.03.011

326-33.

[1] Roger VL et al. Heart Disease and Stroke Statistics - 2012 Update A Report From the

[2] Vasan SV, Benjamin EJ, Sullivan LM, D'agostino RB. The burden of increasing world‐ wide cardiovascular disease. In: Fuster V, Walsh RA, O'Rourke RA, Poole-Wilson P

[3] World Hearth Organitation. WHO: Programes and projects: Cardiovascular disease: The Atlas of Heart Disease and Stroke; 2004. http://www.who.int/cardiovascu‐

[4] Venugopal JR, Prabhakaran MP, Mukherjee S, Ravichandran R, Dan K, Ramakrishna S. Biomaterial Strategies for Alleviation of Myocardial Infarction. Journal of the Roy‐

[5] Walker CA, Spinale FG. The Structure and Function of the Cardiac Myocite: a Re‐ view of Fundamental Concepts. The Journal of Thoracic and Cardiovascular Surgery

[6] Di Donato M, Toso A, Dor V, Sabatier M, Barletta G, Menicanti L, Fantini F and the RESTORE Group. Surgical Ventricular Restoration Improves Mechanical Intraven‐ tricular Dyssynchrony in Ischemic Cardiomyopathy. Circulation 2004; 109: 2536-43. [7] Smaill BH, LeGrice IJ, Hooks DA, Pullan AJ, Caldwell BJ, Hunter PJ. Cardiac Struc‐ ture and Electrical Activation: Models and Measurement. Clinical and Experimental

[8] Kocica MJ, Corno AF, Carreras-Costa F, Ballester-Rodes M, Moghbel MC, Cueva CNC, Lackovic V, Kanjuh V, Torrent-Guasp F. The Helical Ventricular Myocardial Band: Global, Three-Dimensional, Functional Architecture of the Ventricular Myo‐ cardium. European Journal Cardio-Thoracic Surgery 2006; 29: 21-40. DOI: 10.1016/

[9] LeGrice IJ, Smaill BH, Chai LZ, Edgar SG, Gavin JB, Hunter PJ. Laminar Structure of the Heart: Ventricular Myocyte Arrangement and Connective Tissue Architecture in

[10] Chen FY, Cohn LH. The Surgical Treatment of Heart Failure. A New Frontier: Non‐ transplant Surgical Alternatives in Heart Failure. Cardiology in Review 2002; 10(6):

[11] Hoyt RH, Cohen ML, Saffitz JE. Distribution and Three-Dimensional Structure of In‐ tercellular Junctions in Canine Myocardium. Circulation Research 1989; 64: 563-74.

(ed.) Hurst the Heart. 12th edition McGraw-Hill Professional; 2010 p17-46.

American Heart Association. Circulation 2012; 125: 2-220.

lar\_diseases/resources/atlas/en/ (accessed 03 June 2012)

Pharmacology and Physiology 2004; 31 (12): 913-9.

the Dog. American Journal of Physiology 1995; 269: H571-82.

al Society Interface 2012; 9(66): 1-19. doi:10.1098/rsif.2011.0301.

trix and Cellular Cardiomyoplasty for Myocardial Support and Regeneration. Tissue engineering 2007; 13(11): 2681-2687. doi: 10.1089/ten.2006.0447.

[39] Hofmann M, Wollert KC, Meyer GP, Menke A, Arseniev L, Hertenstein B, Ganser A, Knapp WH, Drexler H. Monitoring of Bone Marrow Cell Homing into the Infarcted Human Myocardium. Circulation 2005; 111: 2198-202.

trix and Cellular Cardiomyoplasty for Myocardial Support and Regeneration. Tissue

[26] Jawad H, Ali NN, Lyon AR, Chen QZ, Harding SE, Boccaccini AR. Myocardial Tis‐ sue Engineering: a Review. Journal of Tissue Engineering and Regenerative Medicine

[27] Nelson DM, Mab Z, Fujimoto KL, Hashizume R, Wagner WR. Intra-Myocardial Bio‐ material Injection Therapy in the Treatment of Heart Failure: Materials, Outcomes

[28] Chachques JC, Salanson-Lajos C, Lajos P, Shafy A, Alshamry A, Carpentier A. Cellu‐ lar Cardiomyoplasty for Myocardial Regeneration. Asian Cardiovascular & Thoracic

[29] Chen QZ, Harding SE, Ali NN, Lyon AR, Boccaccini AR. Biomaterials in Cardiac Tis‐ sue Engineering: Ten Years of Research Survey. Materials Science and Engineering

[30] Anversa P, Leri A, Kajstura J, Nadal-Ginard B. Myocyte Growth and Cardiac Repair.

[31] Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabe-Heider F, Walsh S, Zupi‐ cich J, Alkass K, Buchholz BA, Druid H, Jovinge S, Frisén J. Evidence for Cardiomyo‐

[32] Wang F, Guan J. Cellular Cardiomyoplasty and Cardiac Tissue Engineering for Myo‐

[33] Chachques JC, Grandjean PA, Tommasi JJ, Perier P, Chauvaud S, Bourgeois I, Car‐ pentier A. Dynamic Cardiomyoplasty: A New Approach to Assist Chronic Myocar‐

[34] Chachques JC. Development of Bioartificial Myocardium Using Stem Cells and Nanobiotechnology Templates. Cardiology Research and Practice 2011; 2011: 806795.

[35] Wu J, Zeng F, Weisel RD, Li RK. Stem Cells for Cardiac Regeneration by Cell Thera‐ py and Myocardial Tissue Engineering. Advances in Biochemical Engineering/

[36] Pendyala L, Goodchild T, Gadesam RR, Chen J, Robinson K, Chronos N, Hou D. Cel‐ lular cardiomyoplasty and cardiac regeneration. Current Cardiology Reviews 2008;

[37] Leor J, Amsalem Y, Cohen S. Cells, scaffolds, and molecules for myocardial tissue en‐

[38] Zhou R, Acton PD, Ferrari VA. Imaging stem cells implanted in infarcted myocardi‐

cardial Therapy. Advanced Drug Delivery Reviews 2010; 62: 784–797.

Journal of Molecular and Cellular Cardiology 2002; 34: 91-105.

cyte Renewal in Humans. Science 2009; 324(5923): 98-102.

dial Failure. Life Support System 1987; 5(4): 323-7.

Biotechnology 2009; 114: 107-128. doi: 10.1007/10\_2008\_37.

gineering. Pharmacology and Therapeutics 2005; 105(2): 151-63.

um. Journal American college of cardiology 2006; 48(10): 2094-2106.

engineering 2007; 13(11): 2681-2687. doi: 10.1089/ten.2006.0447.

and Challenges. Acta Biomaterialia 2011; 7: 1-15.

2007; 1: 327–342.

306 Regenerative Medicine and Tissue Engineering

Annals 2005; 13: 287-296.

doi:10.4061/2011/806795.

4: 72-80.

2008; 59: 1-37.

and 2, MAGIC, ABCD, PABA-CHF, IMPROVECHF, and Percutaneous Mitral Annu‐ loplasty. European Journal of Heart Failure 2007; 9: 92-7.

[61] Hirata Y, Sata M, Motomura N, Takanashi M, Suematsu Y, Ono M, Takamoto S. Hu‐ man umbilical cord blood cells improve cardiac function after myocardial infarction. Biochemical and Biophysical Research Communications 2005; 327(2): 609-14. doi: 10.1016/j.bbrc.2004.12.044.

[50] Vulliet PR, Greeley M, Halloran SM, MacDonald KA, Kittleson MD. Intra-Coronary Arterial Injection of Mesenchymal Stromal Cells and Microinfarction in Dogs. The

[51] Meyer GP, Wollert KC, Lotz J, Steffens J, Lippolt P, Fichtner S, Hecker H, Schaefer A, Arseniev L, Hertenstein B, Ganser A, Drexler H. Intracoronary Bone Marrow Cell Transfer After Myocardial Infarction: Eighteen Months Follow-up Data from the Randomized, Controlled BOOST (BOne marrOw transfer to enhance ST-elevation in‐ farct regeneration) Trial. Circulation 2006; 113: 1287–94, doi: 10.1161/CIRCULATIO‐

[52] Hahn JY, Cho HJ, Kang HJ, Kim TS, Kim MH, Chung JH, Bae JW, Oh BH, Park YB, Kim HS. Pre-treatment of Mesenchymal Stem Cells with a Combination of Growth Factors Enhances Gap Junction Formation, Cytoprotective Effect on Cardiomyocytes, and Therapeutic Efficacy for Myocardial Infarction. Journal of the American College

[53] Miyahara Y, Nagaya N, Kataoka M, Yanagawa B, Tanaka K, Hao H, Ishino K, Ishida H, Shimizu T, Kangawa K, Sano S, Okano T, Kitamura S, Mori H. Monolayered mes‐ enchymal stem cells repair scarred myocardium after myocardial infarction. Nature

[55] REgeneration of CArdiac Tissue Assisted by Bioactive Implants. funded by the Euro‐

[56] Messina E, De Angelis L, Frati G, Morrone S, Chimenti S, Fiordaliso F, Salio M, Batta‐ glia M, Latronico MV, Coletta M, Vivarelli E, Frati L, Cossu G, Giacomello A. Isola‐ tion and Expansion of Adult Cardiac Stem Cells From Human and Murine Heart.

[57] Smith RR, Barile L, Cho HC, Leppo MK, Hare JM, Messina E, Giacomello A, Abra‐ ham MR, Marbán E. Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation 2007; 115(7):

[58] Makkar RR, Smith RR, Cheng K, Malliaras K, Thomson LEJ, Berman D, Czer LSC, Marbán L, Mendizabal A, Johnston PV, Russell SD, Schuleri KH, Lardo AC, Gersten‐ blith G, Marbán E. Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial.

[59] Shafy A, Lavergne T, Latremouille C, Cortes-Morichetti M, Carpentier A, Chachques JC. Association of electrostimulation with cell transplantation in ischemic heart dis‐

[60] Cleland JG, Coletta AP, Abdellah AT, Nasirb M, Hobsonb N, Freemantlec N, Clarka AL. Clinical Trials Update from the American Heart Association 2006: OAT, SALT 1

ease. Journal of Thoracic and Cardiovascular Surgery 2009; 138(4): 994-1001.

The Lancet 2012; 379: 895-904. doi: 10.1016/S0140- 6736(12)60195-0.

Lancet 2004; 363(9411): 783-4.

of Cardiology 2008; 51(9): 933-43.

Medicine 2006; 12(4): 459-465.

[54] www.clinicaltrials.gov (accessed 13 November 2012).

Circulation Research 2004; 95: 911-921.

896-908.

pean Comission under the 7th FP, www.recatabi.com.

NAHA.105.575118.

308 Regenerative Medicine and Tissue Engineering

[84] Chekanov V, Akhtar M, Tchekanov G, Dangas G, Shehzad MZ, Tio F, Adamian M, Colombo A, Roubin G, Leon MB, Moses JW, Kipshidze NN. Transplantation of autol‐ ogous endothelial cells induces angiogenesis. Pacing and Clinical Electrophysiology 2003; 26(1 Pt 2): 496-9.

[72] Lee WY, Wei HJ, Lin WW, Yeh YC, Hwang SM, Wang JJ, Tsai MS, Chang Y, Sung HW. Enhancement of cell retention and functional benefits in myocardial infarction using human amniotic-fluid stem-cell bodies enriched with endogenous ECM. Bio‐

[73] Ye Z, Zhou Y, Cai H, Tan W. Myocardial regeneration: Roles of stem cells and hydro‐

[74] Habib M, Shapira-Schweitzer K, Caspi O, Gepstein A, Arbel G, Aronson D, Seliktar D, Gepstein L. A combined cell therapy and in-situ tissue-engineering approach for

[75] Wall ST, Walker JC, Healy KE, Ratcliffe MB, Guccione JM. Theoretical impact of the injection of material into the myocardium: a finite element model simulation. Circu‐

[76] Shen X, Tanaka K, Takamori A. Coronary Arteries Angiogenesis in Ischemic Myocar‐ dium: Biocompatibility and Biodegradability of Various Hydrogels. Artificial Organs

[77] Guo HD, Wang HJ, Tan YZ, Wu JH. Transplantation of marrow derived cardiac stem cells carried in fibrin improves cardiac function after myocardial infarction. Tissue

[78] Christman KL, Vardanian AJ, Fang Q, Sievers RE, Fok HH, Lee RJ. Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces ne‐ ovasculature formation in ischemic myocardium. Journal of the American College of

[79] Barsotti MC, Felice F, Balbarini A, Di Stefano R. Fibrin as a scaffold for cardiac tissue Engineering. Biotechnology and Applied Biochemistry 2011; 58(5): 301-10. doi:

[80] Christman KL, Fang Q, Yee MS, Johnson KR, Sievers RE, Lee RJ. Enhanced neovascu‐ lature formation in ischemic myocardium following delivery of pleiotrophin plasmid

[81] Martens TP, Godier AF, Parks JJ, Wan LQ, Koeckert MS, Eng GM, Hudson BI, Sher‐ man W, Vunjak-Novakovic G. Percutaneous cell delivery into the heart using hydro‐

[82] Christman KL, Fok HH, Sievers RE, Fang Q, Lee RJ. Fibrin glue alone and skeletal myoblasts in a fibrin scaffold preserve cardiac function after myocardial infarction.

[83] Ryu JH, Kim IK, Cho SW, Cho MC, Hwang KK, Piao H, Piao S, Lim SH, Hong YS, Choi CY, Yoo KJ, Kim BS. Implantation of bone marrow mononuclear cells using in‐ jectable fibrin matrix enhances neovascularization in infarcted myocardium. Bioma‐

gels polymerizing in situ. Cell Transplantation 2009; 18(3): 297-304.

gels. Advanced Drug Delivery Reviews 2011; 63(8): 688-97.

myocardial repair. Biomaterials 2011; 32(30): 7514-23.

2009; 33(10): 781-7. doi: 10.1111/j.1525-1594.2009.00815.x.

in a biopolymer. Biomaterials 2005; 26(10): 1139-44.

Tissue Engineering 2004; 10 (3-4): 403-9.

terials 2005; 26(3): 319–326.

materials 2011; 32(24): 5558-67.

310 Regenerative Medicine and Tissue Engineering

lation 2006; 114(24): 2627-35.

Engineering Part A 2011; 17(1-2): 45-58.

Cardiology 2004; 44(3): 654-60.

10.1002/bab.49.

[108] Zhang F, He C, Cao L, Feng W, Wang H, Mo X, Wang J. Fabrication of gelatin–hya‐ luronic acid hybrid scaffolds with tunable porous structures for soft tissue engineer‐ ing. International Journal of Biological Macromolecules 2011; 48(3): 474-81.

[96] Yu J, Gu Y, Du KT, Mihardja S, Sievers RE, Lee RJ. The effect of injected RGD modi‐ fied alginate on angiogenesis and left ventricular function in a chronic rat infarct

[97] Tsur-Gang O, Ruvinov E, Landa N, Holbova R, Feinberg MS, Leor J, Cohen S. The effects of peptide-based modification of alginate on left ventricular remodeling and

[98] Mihardja SS, Sievers RE, Lee RJ. The effect of polypyrrole on arteriogenesis in an

[99] Gaffney J, Matou-Nasri S, Grau-Olivares M, Slevin M. Therapeutic applications of hyaluronan. Molecular BioSystems 2010; 6(3): 437–443. doi: 10.1039/b910552m. [100] Yoon SJ, Fang YH, Lim CH, Kim BS, Son HS, Park Y, Sun K. Regeneration of ische‐ mic heart using hyaluronic acid-based injectable hydrogel. Journal of Biomedical Ma‐

[101] Cheng K, Blusztajn A, Shen D, Li TS, Sun B, Galang G, Zarembinski TI, Prestwich GD, Marbán E, Smith RR, Marbán L. Functional performance of human cardio‐ sphere-derived cells delivered in an in situ polymerizable hyaluronan-gelatin hydro‐

[102] Duan Y, Liu Z, O'Neill J, Wan LQ, Freytes DO, Vunjak-Novakovic G. Hybrid gel composed of native heart matrix and collagen induces cardiac differentiation of hu‐ man embryonic stem cells without supplemental growth factors. Journal of Cardio‐

[103] Dai W, Wold LE, Dow JS, Kloner RA. Thickening of the infarcted wall by collagen injection improves left ventricular function in rats: a novel approach to preserve car‐ diac function after myocardial infarction. Journal of the American College of Cardiol‐

[104] Huang NF, Yu J, Sievers R, Li S, Lee RJ. Injectable biopolymers enhance angiogenesis

[105] Thompson CA, Nasseri BA, Makower J, Houser S, McGarry M, Lamson T, Pomerant‐ seva I, Chang JY, Gold HK, Vacanti JP, Oesterle SN. Percutaneous transvenous cellu‐ lar cardiomyoplasty. A novel nonsurgical approach for myocardial cell transplantation. Journal of the American College of Cardiology 2003; 41(11): 1964-71.

[106] Dai W, Hale SL, Kay GL, Jyrala AJ, Kloner RA. Delivering stem cells to the heart in a collagen matrix reduces relocation of cells to other organs as assessed by nanoparti‐

[107] Suuronen EJ, Veinot JP, Wong S, Kapila V, Price J, Griffith M, Mesana TG, Ruel M. Tissue-engineered injectable collagen-based matrices for improved cell delivery and vascularization of ischemic tissue using CD133+ progenitors expanded from the pe‐

after myocardial infarction. Tissue Engineering 2005; 11(11-12): 1860-6.

cle technology. Regenerative Medicine 2009; 4(3): 387-95.

ripheral blood. Circulation 2006; 114(1 Suppl): I138-44.

function after myocardial infarction. Biomaterials 2009; 30(2): 189-95.

acute rat infarct model. Biomaterials 2008; 29(31): 4205–10.

terials Research Part B: Applied Biomaterials 2009; 91(1): 163-71.

model. Biomaterials 2009; 30(5): 751-6.

312 Regenerative Medicine and Tissue Engineering

gel. Biomaterials 2012; 33(21): 5317-24.

ogy 2005; 46(4): 714-9.

vascular Translational Research 2011; 4(5): 605-15.

[130] Engelmayr GC Jr, Cheng M, Bettinger CJ, Borenstein JT, Langer R, Freed LE. Accor‐ dion-like honeycombs for tissue engineering of cardiac anisotropy. Nature Materials 2008; 7: 1003–10.

[119] Wang T, Jiang XJ, Tang QZ, Li XY, Lin T, Wu DQ, Zhang XZ, Okello E. Bone marrow stem cells implantation with a-cyclodextrin/MPEG– PCL–MPEG hydrogel improves cardiac function after myocardial infarction. Acta Biomaterialia 2009; 5(8): 2939-44.

[120] Wu J, Zeng F, Huang XP, Chung JC, Konecny F, Weisel RD, Li RK. Infarct stabiliza‐ tion and cardiac repair with a VEGF-conjugated, injectable Hydrogel. Biomaterials

[121] Kraehenbuehl TP, Ferreira LS, Hayward AM, Nahrendorf M, van der Vlies AJ, Vasile E, Weissleder R, Langer R, Hubbell JA. Human embryonic stem cell-derived micro‐ vascular grafts for cardiac tissue preservation after myocardial infarction. Biomateri‐

[122] Wang T, Jiang XJ, Lin T, Ren S, Li XY, Zhang XZ, Tang QZ. The inhibition of postin‐ farct ventricle remodeling without polycythaemia following local sustained intra‐ myocardial delivery of erythropoietin within a supramolecular hydrogel.

[123] Dvir T, Bauer M, Schroeder A, Tsui JH, Anderson DG, Langer R, Liao R, Kohane DS. Nanoparticles targeting the infarcted heart. Nano Letters 2011; 11(10): 4411-4. doi:

[124] Davis ME, Motion JP, Narmoneva DA, Takahashi T, Hakuno D, Kamm RD, Zhang S, Lee RT. Injectable self-assembling peptide nanofibers create intramyocardial micro‐

[125] Tokunaga M, Liu ML, Nagai T, Iwanaga K, Matsuura K, Takahashi T, Kanda M, Kondo N, Wang P, Naito AT, Komuro I. Implantation of cardiac progenitor cells us‐ ing self-assembling peptide improves cardiac function after myocardial infarction.

[126] Kim JH, Jung Y, Kim SH, Sun K, Choi J, Kim HC, Park Y, Kim SH. The enhancement of mature vessel formation and cardiac function in infarcted hearts using dual growth factor delivery with self-assembling peptides. Biomaterials 2011; 32(26):

[127] Davis ME, Hsieh PC, Takahashi T, Song Q, Zhang S, Kamm RD, Grodzinsky AJ, An‐ versa P, Lee RT. Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Pro‐ ceedings of the National Academy of Sciences of the United States of America 2006;

[128] Nerem RM. The challenge of imitating nature. In Lanza R, Langer R, Vacanti J.. Prin‐ ciples of tissue engineering. San Diego (Ca) USA: Academic press; 1997 p.9-15. [129] Jawad H, Lyon AR, Harding SE, Ali NN, Boccaccini AR. Myocardial tissue engineer‐

environments for endothelial cells.Circulation 2005; 111(4): 442-50.

Journal of Molecular and Cellular Cardiology 2010; 49(6): 972-83.

2011; 32(2): 579-86.

314 Regenerative Medicine and Tissue Engineering

als 2011; 32(4): 1102-9.

10.1021/nl2025882.

6080-8.

103(21): 8155-60.

ing. British Medical Bulletin 2008; 87: 31-47.

Biomaterials 2009; 30(25): 4161-7.

[156] Cimetta E, Pizzato S, Bollini S, Serena E, De Coppi P, Elvassore N. Production of ar‐ rays of cardiac and skeletal muscle myofibers by micropatterning techniques on a soft substrate. Biomedical Microdevices 2009; 11(2): 389-400.

[142] Kaully T, Kaufman-Francis K, Lesman A, Levenberg S. Vascularization--the conduit to viable engineered tissues. Tissue Engineering Part B Reviews 2009; 15(2): 159-69.

[143] Bar A, Haverich A, Hilfiker A. Cardiac tissue engineering: ''Reconstructing the motor

[144] Narmoneva DA, Vukmirovic R, DavisME, Kamm RD, Lee RT. Endothelial cells pro‐ mote cardiacmyocyte survival and spatial reorganization: implications for cardiac re‐

[145] Dvir T, Kedem A, Ruvinov E, Levy O, Freeman I, Landa N, Holbova R, Feinberg MS, Dror S, Etzion Y, Leor J, Cohen S. Prevascularization of cardiac patch on the omen‐ tum improves its therapeutic outcome. Proceedings of the National Academy of Sci‐

[146] Bursac N, Papadaki M, White JA, Eisenberg SR, Vunjak-Novakovic G, Freed LE. Cul‐ tivation in rotating bioreactors promotes maintenance of cardiac myocyte electro‐

physiology and molecular properties. Tissue Engineering 2003; 9(6): 1243-53.

[147] Radisic M, Yang L, Boublik J, Cohen RJ, Langer R, Freed LE, Vunjak-Novakovic G. Medium perfusion enables engineering of compact and contractile cardiac tissue. American Journal of Physiology Heart and Circulatory Physiology 2004; 286(2):

[148] Radisic M, Marsano A, Maidhof R, Wang Y, Vunjak-Novakovic G. Cardiac tissue en‐ gineering using perfusion bioreactor systems. Nature Protocols 2008; 3(4): 719-38.

[149] Maidhof R, Marsano A, Lee EJ, Vunjak-Novakovic G. Perfusion Seeding of Chan‐ neled Elastomeric Scaffolds with Myocytes and Endothelial Cells for Cardiac Tissue

[150] Brown MA, Iyer RK, Radisic M. Pulsatile perfusion bioreactor for cardiac tissue engi‐

[151] Cheng M, Moretti M, Engelmayr GC, Freed LE. Insulin-like Growth Factor-I and Slow, Bi-directional Perfusion Enhance the Formation of Tissue-Engineered Cardiac

[152] Li D, Xia Y. Electrospinning of nanofibers: reinventing the wheel? Advanced Materi‐

[153] Orlova Y, Magome N, Liu L, Chen Y, Agladze K. Electrospun nanofibers as a tool for architecture control in engineered cardiac tissue. Biomaterials 2011; 32(24): 5615-24.

[154] Blan NR, Birla RK. Design and fabrication of heart muscle using scaffold-based tissue engineering. Journal of Biomedical Materials Research Part A 2008; 86(1): 195-208.

[155] Madihally SV, Matthew HW. Porous chitosan scaffolds for tissue engineering. Bio‐

of life''. Scandinavian Journal of surgery 2007; 96 (2): 154-8.

ences from the United States of America 2009; 106 (35): 14990-5.

Engineering. Biotechnology Progress 2010; 26(2): 565-72.

neering. Biotechnology Progress 2008; 24(4): 907-20.

Grafts. Tissue Engineering Part A 2009; 15(3): 645-53.

materials 1999; 20(12): 1133-42.

als 2004; 16(14): 1151–1170. doi: 10.1002/adma.200400719.

generation. Circulation 2004; 110(8): 962-8.

H507-16.

316 Regenerative Medicine and Tissue Engineering

[178] Godier-Furnémont AF, Martens TP, Koeckert MS, Wan L, Parks J, Arai K, Zhang G, Hudson B, Homma S, Vunjak-Novakovic G. Composite scaffold provides a cell de‐ livery platform for cardiovascular repair. Proceedings of the National Academy of Sciences of the United States of America 2011; 108(19): 7974-9.

[166] Akhyari P, Kamiya H, Haverich A, Karck M, Lichtenberg A. Myocardial tissue engi‐ neering: the extracellular matrix. Journal of Cardio-thoracic Surgery 2008; 34:

[167] Sakai T, Li RK, Weisel RD, Mickle DA, Kim ET, Jia ZQ, Yau TM. The fate of a tissueengineered cardiac graft in the right ventricular outflow tract of the rat. Journal of

[168] Zhang G, Nakamura Y, Wang X, Hu Q, Suggs LJ, Zhang J. Controlled release of stro‐ mal cell-derived factor-1 alpha in situ increases c-kit+ cell homing to the infarcted

[169] Leor J, Aboulafia-Etzion S, Dar A, Shapiro L, Barbash IM, Battler A, Granot Y, Cohen S. Bioengineered cardiac grafts: A new approach to repair the infarcted myocardi‐

[170] Dar A, Shachar M, Leor J, Cohen S. Optimization of cardiac cell seeding and distribu‐ tion in 3D porous alginate scaffolds. Biotechnology and Bioengineering 2002; 80(3):

[171] Shachar M, Tsur-Gang O, Dvir T, Leor J, Cohen S. The effect of immobilized RGD peptide in alginate scaffolds on cardiac tissue engineering. Acta Biomaterialia 2011;

[172] Sapir Y, Kryukov O, Cohen S. Integration of multiple cell-matrix interactions into al‐ ginate scaffolds for promoting cardiac tissue regeneration. Biomaterials 2011; 32(7):

[173] Le Visage C, Gournay O, Benguirat N, Hamidi S, Chaussumier L, Mougenot N, Flan‐ ders JA, Isnard R, Michel JB, Hatem S, Letourneur D, Norol F. Mesenchymal stem cell delivery into rat infarcted myocardium using a porous polysaccharide-based scaffold: a quantitative comparison with endocardial injection. Tissue Engineering

[174] Cao Y, Wang B. Biodegradation of Silk Biomaterials. International Journal of Molecu‐

[175] Yang MC, Wang SS, Chou NK, Chi NH, Huang YY, Chang YL, Shieh MJ, Chung TW. The cardiomyogenic differentiation of rat mesenchymal stem cells on silk fibroin–

[176] Patra C, Talukdar S, Novoyatleva T, Velagala SR, Mühlfeld C, Kundu B, Kundu SC, Engel FB. Silk protein fibroin for cardiac tissue engineering. Biomaterials 2012; 33(9):

[177] Robinson KA, Li J, Mathison M, Redkar A, Cui J, Chronos NA, Matheny RG, Badylak SF. Extracellular matrix scaffold for cardiac repair. Circulation 2005; 112(9 Suppl):

polysaccharide cardiac patches in vitro. Biomaterials 2009; 30(22): 3757-65.

Thoracic and Cardiovascular Surgery 2001; 121(5): 932-42.

heart. Tissue Engineering 2007; 13(8): 2063-71.

um? Circulation 2000; 102(19 Suppl 3): III56-61.

229-241.

318 Regenerative Medicine and Tissue Engineering

305-12.

7(1): 152-62.

1838-47.

2673-80.

I135-43.

Part A 2012; 18(1-2): 35-44.

lar Sciences 2009; 10(4): 1514-1524.

[201] Haneef K, Lila N, Benadda S, Legrand F, Carpentier A, Chachques JC. Development of bioartificial myocardium by electrostimulation of 3D collagen scaffolds seeded with stem cells. Heart International 2012; 7(2): e14.

[190] Rockwood DN, Akins RE Jr, Parrag IC, Woodhouse KA, Rabolt JF. Culture on elec‐ trospun polyurethane scaffolds decreases atrial natriuretic peptide expression by car‐ diomyocytes in vitro. Biomaterials 2008; 29(36): 4783-91. doi:10.1016/j.biomaterials.

[191] Guan J, Fujimoto KL, Sacks MS, Wagner WR. Preparation and characterization of highly porous, biodegradable polyurethane scaffolds for soft tissue applications. Bio‐

[192] Fujimoto KL, Tobita K, Merryman WD, Guan J, Momoi N, Stolz DB, Sacks MS, Keller BB, Wagner WR. An elastic, biodegradable cardiac patch induces contractile smooth muscle and improves cardiac remodeling and function in subacute myocardial in‐ farction. Journal of the American College of Cardiology 2007; 49(23): 2292-300. doi:

[193] Siepe M, Giraud MN, Liljensten E, Nydegger U, Menasche P, Carrel T, Tevaearai HT. Construction of skeletal myoblast-based polyurethane scaffolds for myocardial re‐

[194] Chen QZ, Bismarck A, Hansen U, Junaid S, Tran MQ, Harding SE, Ali NN, Boccacci‐ ni AR. Characterisation of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue. Biomaterials 2008; 29(1): 47-57.

[195] Jean A, Engelmayr GC Jr. Finite element analysis of an accordion-like honeycomb scaffold for cardiac tissue engineering. Journal of Biomechanics 2010; 43(15): 3035-43.

[196] Ravichandran R, Venugopal JR, Sundarrajan S, Mukherjee S, Ramakrishna S. Poly(glycerol sebacate)/gelatin core/shell fibrous structure for regeneration of myo‐ cardial infarction. Tissue Engineering Part A 2011; 17(9-10): 1363-73. doi: 10.1089/

[197] Ifkovits JL, Devlin JJ, Eng G, Martens TP, Vunjak-Novakovic G, Burdick JA. Biode‐ gradable fibrous scaffolds with tunable properties formed from photo-cross-linkable poly(glycerol sebacate). ACS Applied Materials and Interfaces 2009; 1(9): 1878-86.

[198] Madden LR, Mortisen DJ, Sussman EM, Dupras SK, Fugate JA, Cuy JL, Hauch KD, Laflamme MA, Murry CE, Ratner BD. Proangiogenic scaffolds as functional tem‐ plates for cardiac tissue engineering. Proceedings of the National Academy of Scien‐ ces of the United States of America 2010; 107(34): 15211-6. doi: 10.1073/pnas.

[199] Arnal-Pastor M, Vallés-Lluch A, Keicher M, Pradas MM. Coating typologies and con‐ strained swelling of hyaluronic acid gels within scaffold pores. Journal of Colloid

[200] Sauer H, Rahimi G, Hescheler J, Wartenberg M. Effects of electrical fields on cardio‐ myocyte differentiation of embryonic stem cells. Journal of Cellular Biochemistry

materials 2005; 26(18): 3961-3971. doi:10.1016/j.biomaterials.2004.10.018.

2008.08.034.

320 Regenerative Medicine and Tissue Engineering

10.1016/j.jacc.2007.02.050.

ten.tea.2010.0441.

1006442107.

1999; 75(4): 710–723.

pair. Artificial Organs 2007; 31(6): 425-33.

and Interface Science 2011; 361(1): 361-9.

[223] Shafy A, Fink T, Zachar V, Lilaa N, Carpentier A, Chachques JC. Development of car‐ diac support bioprostheses for ventricular restoration and myocardial regeneration. European Journal of Cardio-Thoracic Surgery 2012; 0: 1–9. doi:10.1093/ejcts/ezs480.

[213] Chachques JC, Jegaden O, Mesana T, Glock Y, Grandjean PA, Carpentier AF, et al. Cardiac bioassist: results of the French multicenter cardiomyoplasty study. Asian

[214] Kwon MH, Cevasco M, Schmitto JD, Chen FY. Ventricular restraint therapy for heart failure: A review, summary of state of the art, and future directions. Journal of

[215] Liao SY, Siu CW, Liu Y, Zhang Y, Chan WS, Wu EX, Wu Y, Nicholls JM, Li RA, Bens‐ er ME, Rosenberg SP, Park E, Lau CP, Tse HF. Attenuation of left ventricular adverse remodeling with epicardial patching after myocardial infarction. Journal of Cardiac

[216] Enomoto Y, Gorman JH 3rd, Moainie SL, Jackson BM, Parish LM, Plappert T, Zee‐ shan A, St John-Sutton MG, Gorman RC. Early ventricular restraint after myocardial infarction: extent of the wrap determines the outcome of remodeling. Annals of

[217] Klodell CT, Aranda JM, McGiffin DC, Rayburn BK, Sun B, Abraham WT, Pae WE, Boehmer JP, Klein H, Huth C. Worldwide surgical experience with the Paracor HeartNet cardiac restraint device. The Journal of Thoracic and Cardiovascular Sur‐

[218] Costanzo MR, Ivanhoe RJ, Kao A, Anand IS, Bank A, Boehmer J, Demarco T, Hergert CM, Holcomb RG, Maybaum S, Sun B, Vassiliades TA Jr, Rayburn BK, Abraham WT. Prospective evaluation of elastic restraint to lessen the effects of heart failure (PEER‐ LESS-HF) trial. Journal of Cardiac Failure 2012; 18(6): 446-58. doi: 10.1016/j.cardfail.

[219] Dixon JA, Goodman AM, Gaillard WF 2nd, Rivers WT, McKinney RA, Mukherjee R, Baker NL, Ikonomidis JS, Spinale FG. Hemodynamics and myocardial blood flow patterns after placement of a cardiac passive restraint device in a model of dilated cardiomyopathy. Journal of Thoracic and Cardiovascular Surgery 2011; 142: 1038-45.

[220] Pilla JJ, Blom AS, Brockman DJ, Ferrari VA, Yuan Q, Acker MA. Passive ventricular constraint to improve left ventricular function and mechanics in an ovine model of heart failure secondary to acute myocardial infarction. Journal of Thoracic and Cardi‐

[221] Mann DL, Kubo SH, Sabbah HN, Starling RC, Jessup M, Oh JK, Acker MA. Beneficial effects of the CorCap cardiac support device: five-year results from the Acorn Trial.

[222] Olsson A, Bredin F, Franco-Cereceda A. Echocardiographic findings using tissue ve‐ locity imaging following passive containment surgery with the Acorn CorCap car‐ diac support device. European Journal of Cardio-Thoracic Surgery 2005; 28: 448-53.

Journal of Thoracic and Cardiovascular Surgery 2012; 143(5): 1036-42.

Cardiovascular and Thoracic Annals 2009; 17: 573-80.

Failure 2010; 16 (7): 590-8.

322 Regenerative Medicine and Tissue Engineering

gery 2008; 135(1): 188–195.

2012.04.004.

Thoracic Surgery 2005; 79(3): 881-7.

ovascular Surgery 2003; 126(5): 1467-76.

Thoracic and Cardiovascular Surgery 2012; 144(4): 771-777.