*4.8. Statistical Analysis*

To analyze differences between two groups a 2-sided *t*-test and between multiple groups a one-way ANOVA followed by a Tukey's multiple comparison test were employed using Prism 8 software (GraphPad Software, La Jolla, CA, USA). The level of statistical significance was set to *p* < 0.05. All values are given as mean ± standard deviation (SD).