Employee shall have such duties as are customarily performed and exercised by the Chief Medical Officer of a company with subsidiary operations, subject to the supervision of the President and Chief Executive Officer, together with such additional duties as are reasonably assigned by the President and Chief Executive Officer. During the Employment Period, (i) Employee's services shall be performed in metropolitan Philadelphia, PA, or the metropolitan area of any future primary residence, subject to reasonable business travel and based upon the needs of the Company, (ii) Employee shall make her primary personal residence within metropolitan Philadelphia, PA and (iii) subject to applicable law and regulation, including the Board's compliance with its fiduciary duties, Employee shall be appointed to serve on or nominated for election to the Board on or before the Effective Date. Employee acknowledges and agrees to comply with the Company's written policies and procedures during the Employment Period.