This Agreement shall become effective on the Effective Date and, unless earlier terminated pursuant to this Article XV , shall remain in effect on a country-by-country basis or in its entirety until the date on which the Royalty Term expires for such Product in such country (the “ Term ”), whereupon the license granted to Takeda under Section 3.1 shall become non-exclusive, fully-paid, royalty-free, perpetual and irrevocable.