Bayer shall provide written notice to Licensor of the first occurrence of any of the (i) development milestones set forth above in Section 8.2.1 no later than twenty-five (25) Business Days following the occurrence of the relevant milestone, and (ii) sales milestones set forth above in Section 8.2.2 no later than twenty-five (25) Business Days following the end of the month of occurrence of the relevant milestone. Bayer shall remit payment for the applicable milestone due pursuant to Section 8.4.2.