1299. Here, appellant owned and solely operated the vessel carrying the marijuana and qualified as a captain or other opera tion officer. The district court therefore properly enhanced his base offense level pursuant to U.S.S.G. § 2Dl.l(b)(2)(B). Appellant’s sentence is AFFIRMED. 1 . In his brief on appeal, appellant does not challenge his conviction, the general applicability of a statutory mandatory minimum sentence, or the reasonableness of his sentence. We therefore do not consider these issues. See United States v. Blasco, 702 F.2d 1315, 1332 n. 28 (11th Cir.1983). Further, we do not consider the constitutional challenge to the safety valve determination that he raises for the first time in his reply brief. See Sepulveda v. U.S. Att’y Gen., 401 F.3d 1226, 1228 n. 2 (11th Cir.2005)
holding that failure to raise an issue in an opening brief waives that issue holding that a party abandoned an issue by failing to raise it in the opening brief holding that a partys failure to raise an issue in the opening brief waived the issue even though the party raised the issue in his reply brief holding that the failure to raise an issue in the opening brief waives the issue holding that appellant waived issue by failing to raise it in opening brief