how much more of a connection to interstate commerce, if any, must be shown under a substantial rather than a de minimis standard. See Russell, 471 U.S. at 859-60 n. 4, 105 S.Ct. 2455 (suggesting in a pre-Lopez opinion that, under the Commerce Clause, Congress could only reach criminal activity “ ‘substantially affecting interstate commerce.’ ”). It is clear, however, that the direct interstate connection required by Instruction 10 is much more substantial than the indirect interstate connection articulated by the government and disapproved of by the Court in Lopez. In Lopez, the connections articulated by the government between the possession of a firearm in a local school zone and interstate commerce were, to say the least, attenuated. See Lopez, 514 U.S. at 567, 115 S.Ct. 1624 (<HOLDING>); see also Hicks, 106 F.3d at 189 (describing
holding that a reasonable inference need not be the sole possible inference holding that adverse inference rule is permissive recognizing that a vital fact may not be established by piling inference upon inference holding that the nonmovant need not be given the benefit of every inference but only of every reasonable inference recognizing that to uphold the government contentions would require the court to pile inference upon inference