human
TASK: Your task is to answer biomedical questions using the given abstract. Only output yes, no, or maybe as answer.
INPUT: ['MicroRNA-203 (miR-203) serves as a tumor suppressor or a tumor promoter in different human malignancies. However, its involvement in human gliomas is still unclear. The aim of this study was to investigate the clinical significance of miR-203 expression in gliomas.', 'Real-time quantitative PCR was employed to measure the expression level of miR-203 in clinical glioma tissues.', 'The expression of miR-203 was reduced in high WHO grade glioma tissues compared with that in low WHO grade and normal brain tissues, and decreased with ascending tumor WHO grades (P\u2009<\u20090.001). The reduced miR-203 expression in gliomas was significantly associated with higher WHO grade (P\u2009<\u20090.001), lower KPS score (P\u2009=\u20090.008) and poorer disease-specific survival of patients (P\u2009=\u20090.001). More importantly, subgroup analyses according to tumor WHO grade revealed that the disease-specific survival of patients with low miR-203 expression in high WHO grades (III-IV) subgroup was significantly shorter than those with high miR-203 expression (P\u2009<\u20090.001), but no significant difference was found for patients in WHO grades I-II subgroup (P\u2009=\u20090.08).'] Is microRNA-203 down-regulation associated with unfavorable prognosis in human glioma?
OUTPUT:

agent
yes
TASK: Your task is to answer biomedical questions using the given abstract. Only output yes, no, or maybe as answer.
INPUT: ['MicroRNA-203 (miR-203) serves as a tumor suppressor or a tumor promoter in different human malignancies. However, its involvement in human gliomas is still unclear. The aim of this study was to investigate the clinical significance of miR-203 expression in gliomas.', 'Real-time quantitative PCR was employed to measure the expression level of miR-203 in clinical glioma tissues.', 'The expression of miR-203 was reduced in high WHO grade glioma tissues compared with that in low WHO grade and normal brain tissues, and decreased with ascending tumor WHO grades (P\u2009<\u20090.001). The reduced miR-203 expression in gliomas was significantly associated with higher WHO grade (P\u2009<\u20090.001), lower KPS score (P\u2009=\u20090.008) and poorer disease-specific survival of patients (P\u2009=\u20090.001). More importantly, subgroup analyses according to tumor WHO grade revealed that the disease-specific survival of patients with low miR-203 expression in high WHO grades (III-IV) subgroup was significantly shorter than those with high miR-203 expression (P\u2009<\u20090.001), but no significant difference was found for patients in WHO grades I-II subgroup (P\u2009=\u20090.08).'] Is microRNA-203 down-regulation associated with unfavorable prognosis in human glioma?
OUTPUT:
