human
TASK: Your task is to answer biomedical questions using the given abstract. Only output yes, no, or maybe as answer.
INPUT: ['To compare inflammatory cytokine and defensin expression in response to experimental dry eye (EDE) in interleukin-1 receptor-1 (IL-1R1)-deficient (KO) mice with age-matched wild-type mice (WT).', 'EDE was induced by subcutaneous scopolamine injection, exposure to low humidity, and an air draft for 5 days in 4- to 6-week-old KO and WT mice. Expression of cytokines IL-1 alpha, IL-1 beta, tumor necrosis factor (TNF)-alpha, IL-6, and mouse beta-defensins (mBD)-1, mBD-2, and mBD-3 was evaluated by real-time polymerase chain reaction in scraped corneal epithelial cells and whole conjunctival tissues. A multiplex bead assay was performed to quantitate IL-1 alpha, IL-2, IL-4, IL-10, interferon (IFN)-gamma, and TNF-alpha levels in tear fluid, and an enzyme immunoassay was used to quantitate IL-1 beta levels in tear fluid.', 'EDE significantly increased RNA transcripts for IL-1 alpha and beta in the conjunctiva and for TNF-alpha in the corneal epithelium of WT mice. Levels of IL-1 alpha, IL-1 beta, and IL-6 were significantly lower in the corneal epithelium and conjunctiva, and TNF-alpha was significantly lower in the cornea of KO mice after 5 days of EDE than WT mice. Tear fluid IL-1 alpha concentration increased above baseline on days 2-4 of EDE in WT and KO mice. A similar pattern was observed for tear TNF-alpha. Tear IL-1 beta increased throughout the 5 days of EDE in WT and KO mice. IFN-gamma, IL-2, IL-4, and IL-10 were undetectable in tear fluid of either strain before or after EDE. Corneal mBD-1 mRNA expression was unchanged and conjunctival mBD-1 transcripts decreased in WT and increased in KO mice with EDE. Untreated WT corneas, but not those of KO mice, expressed mBD-2 transcripts, whereas in the conjunctiva, mBD-2 increased in WT and decreased in KO mice with EDE. Corneal mBD-3 mRNA expression was undetected in WT mice, but increased after EDE in KO mice. Conjunctival mBD-3 transcripts were only detected in WT with EDE.'] Do interleukin-1 receptor-1-deficient mice show attenuated production of ocular surface inflammatory cytokines in experimental dry eye?
OUTPUT:

agent
yes
TASK: Your task is to answer biomedical questions using the given abstract. Only output yes, no, or maybe as answer.
INPUT: ['To compare inflammatory cytokine and defensin expression in response to experimental dry eye (EDE) in interleukin-1 receptor-1 (IL-1R1)-deficient (KO) mice with age-matched wild-type mice (WT).', 'EDE was induced by subcutaneous scopolamine injection, exposure to low humidity, and an air draft for 5 days in 4- to 6-week-old KO and WT mice. Expression of cytokines IL-1 alpha, IL-1 beta, tumor necrosis factor (TNF)-alpha, IL-6, and mouse beta-defensins (mBD)-1, mBD-2, and mBD-3 was evaluated by real-time polymerase chain reaction in scraped corneal epithelial cells and whole conjunctival tissues. A multiplex bead assay was performed to quantitate IL-1 alpha, IL-2, IL-4, IL-10, interferon (IFN)-gamma, and TNF-alpha levels in tear fluid, and an enzyme immunoassay was used to quantitate IL-1 beta levels in tear fluid.', 'EDE significantly increased RNA transcripts for IL-1 alpha and beta in the conjunctiva and for TNF-alpha in the corneal epithelium of WT mice. Levels of IL-1 alpha, IL-1 beta, and IL-6 were significantly lower in the corneal epithelium and conjunctiva, and TNF-alpha was significantly lower in the cornea of KO mice after 5 days of EDE than WT mice. Tear fluid IL-1 alpha concentration increased above baseline on days 2-4 of EDE in WT and KO mice. A similar pattern was observed for tear TNF-alpha. Tear IL-1 beta increased throughout the 5 days of EDE in WT and KO mice. IFN-gamma, IL-2, IL-4, and IL-10 were undetectable in tear fluid of either strain before or after EDE. Corneal mBD-1 mRNA expression was unchanged and conjunctival mBD-1 transcripts decreased in WT and increased in KO mice with EDE. Untreated WT corneas, but not those of KO mice, expressed mBD-2 transcripts, whereas in the conjunctiva, mBD-2 increased in WT and decreased in KO mice with EDE. Corneal mBD-3 mRNA expression was undetected in WT mice, but increased after EDE in KO mice. Conjunctival mBD-3 transcripts were only detected in WT with EDE.'] Do interleukin-1 receptor-1-deficient mice show attenuated production of ocular surface inflammatory cytokines in experimental dry eye?
OUTPUT:
