human
TASK: Your task is to answer biomedical questions using the given abstract. Only output yes, no, or maybe as answer.
INPUT: ['A new prostate cancer (PCa) grading system (namely, Gleason score-GS- ≤6 vs. 3\u2009+\u20094 vs. 4\u2009+\u20093 vs. 8 vs. ≥9) was recently proposed and assessed on biochemical recurrence (BCR) showing improved predictive abilities compared to the commonly used three-tier system (GS ≤6 vs. 7 vs. ≥8). We assessed the predictive ability of the five-tier grade group (GG) system on harder clinical endpoint, namely clinical recurrence (CR).', 'Between 2005 and 2014, 9,728 clinically localized PCa patients were treated with radical prostatectomy (RP) at two tertiary referral centers. Kaplan-Meier curves, multivariable Cox regression analyses, and concordance index (C-index) were used to assess CR after treatment according to four Gleason grade classifications at biopsy and RP: Group 1: ≤6 versus 7 versus ≥8; Group 2: ≤6 versus 3\u2009+\u20094 vs. 4\u2009+\u20093 versus ≥8; Group 3: ≤6 versus 7 versus 8 versus ≥9; Group 4: ≤6 versus 3\u2009+\u20094 versus 4\u2009+\u20093 versus 8 versus ≥9. Same analyses were repeated in patients who had BCR (n\u2009=\u20091,624). Decision curve analyses were performed to evaluate and compare the net benefit associated with the use of the four Gleason grade classifications.', 'Overall, 443 (4.6%) patients had CR. The hazard ratio of the GS 3\u2009+\u20094, 4\u2009+\u20093, 8, and ≥9 relative to GS ≤6 were 3.63, 5.93, 11.44, 18.08 and 4.93, 9.99, 15.31 and 25.12 in the pre- and post-treatment models, respectively. The C-index of the five-tier GG system was slightly higher relative to the other 3 Gleason grade classifications both in the pre- (range: 0.001-0.006) and post-treatment models (range: 0-0.008). Similar findings were observed when we focused our analyses in patients with BCR after RP. The use of the five-tier GG system did not result into higher net-benefit relative to the other three Gleason grade classifications.'] Does the New Prostate Cancer Grading System Improve Prediction of Clinical Recurrence After Radical Prostatectomy : Results of a Large , Two-Center Validation Study?
OUTPUT:

agent
no
TASK: Your task is to answer biomedical questions using the given abstract. Only output yes, no, or maybe as answer.
INPUT: ['A new prostate cancer (PCa) grading system (namely, Gleason score-GS- ≤6 vs. 3\u2009+\u20094 vs. 4\u2009+\u20093 vs. 8 vs. ≥9) was recently proposed and assessed on biochemical recurrence (BCR) showing improved predictive abilities compared to the commonly used three-tier system (GS ≤6 vs. 7 vs. ≥8). We assessed the predictive ability of the five-tier grade group (GG) system on harder clinical endpoint, namely clinical recurrence (CR).', 'Between 2005 and 2014, 9,728 clinically localized PCa patients were treated with radical prostatectomy (RP) at two tertiary referral centers. Kaplan-Meier curves, multivariable Cox regression analyses, and concordance index (C-index) were used to assess CR after treatment according to four Gleason grade classifications at biopsy and RP: Group 1: ≤6 versus 7 versus ≥8; Group 2: ≤6 versus 3\u2009+\u20094 vs. 4\u2009+\u20093 versus ≥8; Group 3: ≤6 versus 7 versus 8 versus ≥9; Group 4: ≤6 versus 3\u2009+\u20094 versus 4\u2009+\u20093 versus 8 versus ≥9. Same analyses were repeated in patients who had BCR (n\u2009=\u20091,624). Decision curve analyses were performed to evaluate and compare the net benefit associated with the use of the four Gleason grade classifications.', 'Overall, 443 (4.6%) patients had CR. The hazard ratio of the GS 3\u2009+\u20094, 4\u2009+\u20093, 8, and ≥9 relative to GS ≤6 were 3.63, 5.93, 11.44, 18.08 and 4.93, 9.99, 15.31 and 25.12 in the pre- and post-treatment models, respectively. The C-index of the five-tier GG system was slightly higher relative to the other 3 Gleason grade classifications both in the pre- (range: 0.001-0.006) and post-treatment models (range: 0-0.008). Similar findings were observed when we focused our analyses in patients with BCR after RP. The use of the five-tier GG system did not result into higher net-benefit relative to the other three Gleason grade classifications.'] Does the New Prostate Cancer Grading System Improve Prediction of Clinical Recurrence After Radical Prostatectomy : Results of a Large , Two-Center Validation Study?
OUTPUT:
