human
TASK: Your task is to answer biomedical questions using the given abstract. Only output yes, no, or maybe as answer.
INPUT: ['Chronic Obstructive Pulmonary Disease (COPD) is a complex disease with strong environmental and genetic influences and sexually dimorphic features. Although genetic risk factors for COPD have been identified, much of the heritability remains unexplained. Sex-based genetic association studies may uncover additional COPD genetic risk factors.', 'We studied current and former smokers from COPD case-control cohorts (COPDGene non-Hispanic whites and African Americans, ECLIPSE, and GenKOLS). COPD was defined as post-bronchodilator FEV1/FVC<0.70 and FEV1 percent predicted<80. Testing was performed across all cohorts and combined in a meta-analysis adjusted for age, pack-years and genetic ancestry. We first performed genome-wide SNP-by-sex interaction testing on the outcome COPD affection status. We performed sex-stratified association testing for SNPs with interaction P < 10-6.', 'We examined over 8 million SNPs in four populations including 6260 COPD cases (40.6% female) and 5269 smoking control subjects (47.3% female). The SNP rs9615358 in the cadherin gene, CELSR1, approached genome-wide significance for an interaction with sex (P=1.24x10-7). In the sex-stratified meta-analysis, this SNP was associated with COPD among females (OR 1.37 [1.25, 1.49], P=3.32 x10-7) but not males (OR 0.90 [0.79, 1.01], P=0.06). CELSR1 is involved in fetal lung development. In a human fetal lung tissue dataset, we observed greater CELSR1 expression in female compared to male samples.'] Does sex-based Genetic Association Study identify CELSR1 as a Possible COPD Risk Locus Among Women?
OUTPUT:

agent
yes
TASK: Your task is to answer biomedical questions using the given abstract. Only output yes, no, or maybe as answer.
INPUT: ['Chronic Obstructive Pulmonary Disease (COPD) is a complex disease with strong environmental and genetic influences and sexually dimorphic features. Although genetic risk factors for COPD have been identified, much of the heritability remains unexplained. Sex-based genetic association studies may uncover additional COPD genetic risk factors.', 'We studied current and former smokers from COPD case-control cohorts (COPDGene non-Hispanic whites and African Americans, ECLIPSE, and GenKOLS). COPD was defined as post-bronchodilator FEV1/FVC<0.70 and FEV1 percent predicted<80. Testing was performed across all cohorts and combined in a meta-analysis adjusted for age, pack-years and genetic ancestry. We first performed genome-wide SNP-by-sex interaction testing on the outcome COPD affection status. We performed sex-stratified association testing for SNPs with interaction P < 10-6.', 'We examined over 8 million SNPs in four populations including 6260 COPD cases (40.6% female) and 5269 smoking control subjects (47.3% female). The SNP rs9615358 in the cadherin gene, CELSR1, approached genome-wide significance for an interaction with sex (P=1.24x10-7). In the sex-stratified meta-analysis, this SNP was associated with COPD among females (OR 1.37 [1.25, 1.49], P=3.32 x10-7) but not males (OR 0.90 [0.79, 1.01], P=0.06). CELSR1 is involved in fetal lung development. In a human fetal lung tissue dataset, we observed greater CELSR1 expression in female compared to male samples.'] Does sex-based Genetic Association Study identify CELSR1 as a Possible COPD Risk Locus Among Women?
OUTPUT:
