human
TASK: Your task is to answer biomedical questions using the given abstract. Only output yes, no, or maybe as answer.
INPUT: ['Electrical stimulation of the lower esophageal sphincter (LES) has been shown to improve outcomes in patients with gastroesophageal reflux disease (GERD) at 2\xa0years. The aim of the study was to evaluate the safety and efficacy of LES stimulation in the same cohort at 3\xa0years.', 'GERD patients with partial response to PPI, with % 24-h esophageal pH\xa0<\xa04.0 for >5\xa0%, with hiatal hernia <3\xa0cm and with esophagitis ≤LA grade C were treated with LES stimulation in an open-label 2-year trial. All patients were on fixed stimulation parameter of 20\xa0Hz, 220\xa0μs, 5\xa0mA delivered in twelve, 30-min sessions. After completing the 2-year open-label study, they were offered enrollment into a multicenter registry trial and were evaluated using GERD-HRQL, symptom diaries and pH testing at their 3-year follow-up.', 'Fifteen patients completed their 3-year evaluation [mean (SD) age\xa0=\xa056.1 (9.7) years; men\xa0=\xa08] on LES stimulation. At 3\xa0years, there was a significant improvement in their median (IQR) GERD-HRQL on electrical stimulation compared to both their on PPI [9 (6-10) vs. 1 (0-2), p\xa0=\xa00.001] and off PPI [22 (21-24) vs. 1 (0-2), p\xa0<\xa00.001]. Median 24-h distal esophageal acid exposure was significantly reduced from [10.3 (7.5-11.6) % at baseline vs. 3 (1.9-4.5) %, p\xa0<\xa00.001] at 3 years. Seventy-three % (11/15) patients had normalized their distal esophageal acid exposure at 3\xa0years. Remaining four patients had improved their distal esophageal acid exposure by 39-48\xa0% from baseline. All but four patients reported cessation of regular PPI use (>50\xa0% of days with PPI use); three had normal esophageal pH at 3\xa0years. There were no unanticipated device- or stimulation-related adverse events or untoward sensation reported during the 2- to 3-year follow-up.'] Is electrical stimulation therapy of the lower esophageal sphincter successful in treating GERD : long-term 3-year results?
OUTPUT:

agent
yes
TASK: Your task is to answer biomedical questions using the given abstract. Only output yes, no, or maybe as answer.
INPUT: ['Electrical stimulation of the lower esophageal sphincter (LES) has been shown to improve outcomes in patients with gastroesophageal reflux disease (GERD) at 2\xa0years. The aim of the study was to evaluate the safety and efficacy of LES stimulation in the same cohort at 3\xa0years.', 'GERD patients with partial response to PPI, with % 24-h esophageal pH\xa0<\xa04.0 for >5\xa0%, with hiatal hernia <3\xa0cm and with esophagitis ≤LA grade C were treated with LES stimulation in an open-label 2-year trial. All patients were on fixed stimulation parameter of 20\xa0Hz, 220\xa0μs, 5\xa0mA delivered in twelve, 30-min sessions. After completing the 2-year open-label study, they were offered enrollment into a multicenter registry trial and were evaluated using GERD-HRQL, symptom diaries and pH testing at their 3-year follow-up.', 'Fifteen patients completed their 3-year evaluation [mean (SD) age\xa0=\xa056.1 (9.7) years; men\xa0=\xa08] on LES stimulation. At 3\xa0years, there was a significant improvement in their median (IQR) GERD-HRQL on electrical stimulation compared to both their on PPI [9 (6-10) vs. 1 (0-2), p\xa0=\xa00.001] and off PPI [22 (21-24) vs. 1 (0-2), p\xa0<\xa00.001]. Median 24-h distal esophageal acid exposure was significantly reduced from [10.3 (7.5-11.6) % at baseline vs. 3 (1.9-4.5) %, p\xa0<\xa00.001] at 3 years. Seventy-three % (11/15) patients had normalized their distal esophageal acid exposure at 3\xa0years. Remaining four patients had improved their distal esophageal acid exposure by 39-48\xa0% from baseline. All but four patients reported cessation of regular PPI use (>50\xa0% of days with PPI use); three had normal esophageal pH at 3\xa0years. There were no unanticipated device- or stimulation-related adverse events or untoward sensation reported during the 2- to 3-year follow-up.'] Is electrical stimulation therapy of the lower esophageal sphincter successful in treating GERD : long-term 3-year results?
OUTPUT:
