human
TASK: Your task is to answer biomedical questions using the given abstract. Only output yes, no, or maybe as answer.
INPUT: ['It has been reported that obesity-related high blood pressure was partly associated with increased aldosterone secretion and/or activity, but detailed mechanisms are not known. Our previous study suggested that different salt contents in each diet would affect the aldosterone levels. In this study, we investigated the change of aldosterone secretion and MR sensitivity of obesity mice by high fat diet under equally-adjusted salt intake.', 'We prepared normal fat diet (NFD, 10% lard) and high fat diet (HFD, 60% lard) with equal amount of salt based on the amount of food intake of C57BL/6J mice. The 4-week-old male C57BL/6J mice were fed with NFD or HFD until sacrificed for analysis. Animals were monitored with various physiological parameters and measured plasma renin and aldosterone, urinary albumin, electrolytes, and aldosterone. Messenger RNA levels of steroidogenic enzyme genes in adrenal glands and MR target genes in kidneys were quantitated by real-time RT-PCR assay.', 'We confirmed that salt intake was equally-adjusted in two groups by measuring amount of food intake and urine sodium excretion. There was no significant difference in plasma aldosterone concentrations between HFD mice and NFD mice at any time point. Cyp11b2 expression was increased in 8-week HFD mice, however, not changed in 16-week and older HFD mice. Body weight and systolic BP were expectedly higher in HFD mice than in NFD mice. Sgk1 expression and urinary albumin were increased in 28-week and 42-week HFD mice compared with NFD mice.'] Does oS 25-01 MR SENSITIVITY be ENHANCED IN HIGH FAT DIET MICE UNDER EQUALLY-ADJUSTED SALT INTAKE?
OUTPUT:

agent
yes
TASK: Your task is to answer biomedical questions using the given abstract. Only output yes, no, or maybe as answer.
INPUT: ['It has been reported that obesity-related high blood pressure was partly associated with increased aldosterone secretion and/or activity, but detailed mechanisms are not known. Our previous study suggested that different salt contents in each diet would affect the aldosterone levels. In this study, we investigated the change of aldosterone secretion and MR sensitivity of obesity mice by high fat diet under equally-adjusted salt intake.', 'We prepared normal fat diet (NFD, 10% lard) and high fat diet (HFD, 60% lard) with equal amount of salt based on the amount of food intake of C57BL/6J mice. The 4-week-old male C57BL/6J mice were fed with NFD or HFD until sacrificed for analysis. Animals were monitored with various physiological parameters and measured plasma renin and aldosterone, urinary albumin, electrolytes, and aldosterone. Messenger RNA levels of steroidogenic enzyme genes in adrenal glands and MR target genes in kidneys were quantitated by real-time RT-PCR assay.', 'We confirmed that salt intake was equally-adjusted in two groups by measuring amount of food intake and urine sodium excretion. There was no significant difference in plasma aldosterone concentrations between HFD mice and NFD mice at any time point. Cyp11b2 expression was increased in 8-week HFD mice, however, not changed in 16-week and older HFD mice. Body weight and systolic BP were expectedly higher in HFD mice than in NFD mice. Sgk1 expression and urinary albumin were increased in 28-week and 42-week HFD mice compared with NFD mice.'] Does oS 25-01 MR SENSITIVITY be ENHANCED IN HIGH FAT DIET MICE UNDER EQUALLY-ADJUSTED SALT INTAKE?
OUTPUT:
