human
TASK: Your task is to answer biomedical questions using the given abstract. Only output yes, no, or maybe as answer.
INPUT: ['The migration and proliferation of vascular smooth muscle cells (VSMC) are early and crucial events in the pathogenesis of intimal hyperplasia, the primary cause of restenosis after vascular reconstruction. We tested the hypothesis that down-regulation of Rab5a, a prototypical member of the Rab family of GTPases, leads to inhibition ofVSMC proliferation and migration in the rat model.', 'The intimal hyperplasia rat model was established and was used to test the expression of Rab5a at the vascular anastomoses at 7, 14 and 28 days post-operatively. The VSMCs were isolated from the thoracic aorta of SD rats and the expression of Rab5a was tested before and after exposure to RNAi by real-time PCR and Western blot.VSMC migration and proliferation were detected by flow cytometry using standard commercially available techniques and aTranswell chamber.', 'The rat models had significant stenosis at the anastomoses and the intima/media ratio was higher than that of the rat vessels. The expression of Rab5a was higher at the anastomotic site and peaked at 14 days after operation. The expression of Rab5a increased in the cultured VSMCs and decreased after RNAi. Proliferation and migration ofVSMCs had been inhibited by down-regulating the expression of Rab5a.'] Does rNAi-mediated Rab5a suppression inhibit proliferation and migration of vascular smooth muscle cells?
OUTPUT:

agent
yes
TASK: Your task is to answer biomedical questions using the given abstract. Only output yes, no, or maybe as answer.
INPUT: ['The migration and proliferation of vascular smooth muscle cells (VSMC) are early and crucial events in the pathogenesis of intimal hyperplasia, the primary cause of restenosis after vascular reconstruction. We tested the hypothesis that down-regulation of Rab5a, a prototypical member of the Rab family of GTPases, leads to inhibition ofVSMC proliferation and migration in the rat model.', 'The intimal hyperplasia rat model was established and was used to test the expression of Rab5a at the vascular anastomoses at 7, 14 and 28 days post-operatively. The VSMCs were isolated from the thoracic aorta of SD rats and the expression of Rab5a was tested before and after exposure to RNAi by real-time PCR and Western blot.VSMC migration and proliferation were detected by flow cytometry using standard commercially available techniques and aTranswell chamber.', 'The rat models had significant stenosis at the anastomoses and the intima/media ratio was higher than that of the rat vessels. The expression of Rab5a was higher at the anastomotic site and peaked at 14 days after operation. The expression of Rab5a increased in the cultured VSMCs and decreased after RNAi. Proliferation and migration ofVSMCs had been inhibited by down-regulating the expression of Rab5a.'] Does rNAi-mediated Rab5a suppression inhibit proliferation and migration of vascular smooth muscle cells?
OUTPUT:
