def set_env(name, value, current=True):
    root = winreg.HKEY_CURRENT_USER if current else winreg.HKEY_LOCAL_MACHINE
    key = winreg.OpenKey(root, "Environment")
    try:
        _x, key_type = winreg.QueryValueEx(key, name)
    except WindowsError:
        key_type = winreg.REG_EXPAND_SZ
    key = winreg.OpenKey(root, "Environment", 0, winreg.KEY_SET_VALUE)
    winreg.SetValueEx(key, name, 0, key_type, value)
    from win32gui import SendMessageTimeout
    from win32con import (HWND_BROADCAST, WM_SETTINGCHANGE,
                          SMTO_ABORTIFHUNG)
    SendMessageTimeout(HWND_BROADCAST, WM_SETTINGCHANGE, 0,
                       "Environment", SMTO_ABORTIFHUNG, 5000)


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Set HKCU/HKLM environment variables
dataset/ETHPy150Open winpython/winpython/winpython/utils.py/set_env