Hard to Handle (song)

"Hard to Handle" is a 1968 song written by American soul singer Otis Redding along with Al Bell and Allen Jones. Originally recorded by Redding, it was released in 1968 as the B-side to "Amen" (shortly after the singer's sudden death in 1967). The song also appears on the 1968 album "The Immortal Otis Redding". Redding's version reached No. 38 on the Billboard R&B charts and No. 51 on the pop charts.
The Black Crowes version.
Perhaps the most notable cover is by American rock band the Black Crowes, for whom it was a breakout hit single from their 1990 debut album "Shake Your Money Maker". Two versions of the song exist: the original album version and the hit single remixed with an overdubbed brass section. The Crowes' version reached number one on the "Billboard" Album Rock Tracks chart and number 26 on the "Billboard" Hot 100.
A cover version in the style of the Black Crowes is available as a downloadable track for the music video game series "Rock Band". Another covered version by Steve Ouimette is in the video game "".
Track listings.
US 7-inch and cassette single
International 7-inch and cassette single
UK CD single (1990)
UK and European 7-inch single (1991)
UK and European CD single (1991)


Inflamed seborrheic keratosis


Thermodynamics of micellization

The surfactant’s critical micelle concentration (CMC) plays a factor in Gibbs free energy of micellization. The exact concentration of the surfactants that yield the aggregates being thermodynamically soluble is the CMC. The Krafft temperature determines the solubility of the surfactants which in turn is the temperature that CMC is achieved. There are many parameters that affect the CMC. The interaction between the hydrophilic heads and the hydrophobic tails play a part, as well as the concentration of salt within the solution and surfactants.
Micelle.
A micelle is an aggregation of surfactants or block copolymer in aqueous solution or organic solution, often spherical.
Surfactants.
Surfactants are composed of a polar head group that is hydrophilic and a nonpolar tail group that is hydrophobic. The head groups can be anionic, cationic, zwitterionic, or nonionic. The tail group can be a hydrocarbon, fluorocarbon, or a siloxane. Extensive variation in the surfactant’s solution and interfacial properties is allowed through different molecular structures of surfactants.
Hydrophobic coagulation occurs when a positively charged solution is added with a sodium alkyl sulfate. The coagulation value is smaller when the alkyl chain length of the coagulator is longer. Hydrophobic coagulation occurs when a negatively charged solution contains a cationic surfactant. The coulomb attraction between the head groups and surface competes with the hydrophobic attraction for the entire tail in a favorable manner.
Block copolymer.
Block copolymers are interesting because they can "microphase separate" to form periodic nanostructures,[13][14][15] Microphase separation is a situation similar to that of oil and water. Oil and water are immiscible - they phase separate. Due to incompatibility between the blocks, block copolymers undergo a similar phase separation. Because the blocks are covalently bonded to each other, they cannot demix macroscopically as water and oil. In "microphase separation" the blocks form nanometer-sized structures.
Driving mechanism for micellization.
The driving mechanism for micellization is the transfer of hydrocarbon chains from water into the oil-like interior. This entropic effect is called the hydrophobic effect. Compared to the increase of entropy of the surrounding water molecules, this hydrophobic interaction is relatively small. The water molecules are highly ordered around the hydrocarbon chain. The CMC decreases while the length of the alkyl chain increases when all the hydrocarbon chains are hidden inside micelles.
Ionic micelles and salt concentration.
The driving force for adsorption is the attraction between the surface and the surfactant head-group with low surfactant concentrations and the adsorption on hydrophilic surfaces. This means that the surfactant adsorbs at low surfactant concentrations with its head-group contacting the surface.
Depending on the type of head-group and surface, the attraction will have a short-range contribution for both non-ionic and ionic surfactants. Ionic surfactants will also experience a generic electrostatic interaction. If the surfactants and the surface are oppositely charged then the interaction will be attractive. If the surfactants and the surface are like charges then the interaction will be repulsive.
Aggregation is opposed due to the repulsion of the polar head groups as they come closer to each other. Hydration repulsion occurs because head groups have to be dehydrated as they come closer to each other. The head groups’ thermal fluctuations become smaller as they come closer together because they are confined by neighboring head groups. This causes their entropy to decrease and leads to a repulsion.
Gibbs free energy of micellization.
In general, the Gibbs free energy of micellization can be approximated as:
formula_1
where formula_2 is the change in Gibbs free energy of micellization, formula_3 is the universal gas constant, formula_4 is the absolute temperature, and formula_5 is the critical micelle concentration.
Non-ionic micelles.
Two methods to extract the Gibbs free energy based on the value of CMC and formula_6 exist; Phillips method based on the law of mass action and the pseudo-phase separation model. The law of mass action postulates that the micelle formation can be modeled as a chemical equilibrium process between the micelles formula_7 and its constituents, the surfactant monomers, formula_8:
formula_9,
where formula_6 is the average number of surfactant monomers in solution that associate into a micelle, commonly denoted the aggregation number.
The equilibrium is characterized by an equilibrium constant defined by formula_11, where formula_12 and formula_13 are the concentrations of micelles and free surfactant monomers, respectively. In combination with the law of conservation of mass, the system is fully specified by: formula_14, where formula_15 is the total surfactant concentration. Phillips defined the CMC as the point corresponding to the maximum change in gradient in an ideal property-concentration (formula_16 against formula_15) relationship formula_18=0. By implicit differentiation of formula_14 three times with respect to formula_15 and equating to zero it can be shown that the micellization constant is given by formula_21 for formula_22. According to Phillips method the Gibbs free energy change of micellization is therefore given by:
formula_23
The pseudo-phase separation model was originally derived on its own basis, but it has later been shown that it can be interpreted as an approximation to the mass-action model for large formula_6. That is, for micelles behaving in accordance with the law of mass-action, the pseudo-phase phase separation model is only an approximation and will only become asymptotically equal to the mass-action model as the micelle becomes a true macroscopic phase i.e. for formula_6→∞. However, the approximation that the aggregation number formula_6 is large is in most cases sufficient:
formula_27
Ionic micelles.
Ionic micelles are typically very affected by the salt concentration. In ionic micelles the monomers are typically fully ionized, but the high electric field strength at the surface of the micelles will cause adsorption of some proportion of the free counter-ions. In this case a chemical equilibrium process can be assumed between the charged micelles formula_28 and its constituents, the bile salt monomers, formula_29 and bound counter-ions formula_30:
formula_31
where formula_6 is the average aggregation number and formula_33 is the average degree of counter-ion binding to the micelle. In this case, the Gibbs free energy is given by:
formula_34
where formula_2 is the Gibbs energy of micellization and formula_36 is the free counter-ion concentration at CMC. For large formula_6, that is in the limit when then the micelles becomes a true macroscopic phase, the Gibbs free energy is usually approximated by:
formula_38
Dressed micelle model.
In the dressed micelle model, the total Gibbs energy is broken down into several components accounting for the hydrophobic tail, the electrostatic repulsion of the head groups, and the interfacial energy on the surface of the micelle.
formula_39
where the components of the total Gibbs micellization energy are hydrophobic, electrostatic, and interfacial.
Effect of concentration and temperature.
Solubility and cloud point.
Specific temperature at a specific pressure at which large groups of micelles begin to precipitate out into a quasi-separate phase. As temperature is raised above the cloud point this causes the distinct surfactant phase to form densely packed micelle groups known as aggregates. The phase separation is a reversible separation controlled by enthalpy (promotes aggregation/separation) above the cloud point, and entropy (promotes miscibility of micelles in water) below the cloud point. The cloud point is the equilibrium between the two free energies.
Critical micelle concentration.
The critical micelle concentration (CMC) is the exact concentration of surfactants at which aggregates become thermodynamically soluble in an aqueous solution. Below the CMC there is not a high enough density of surfactant to spontaneously precipitate into a distinct phase. Above the CMC, the solubility of the surfactant within the aqueous solution has been exceeded. The energy required to keep the surfactant in solution no longer is the lowest energy state. To decrease free energy of the system the surfactant is precipitated out. CMC is determined by establishing inflection points for pre-determined surface tension of surfactants in solution. Plotting the inflection point against the surfactant concentration will provide insight into the critical micelle concentration by showing stabilization of phases.
Krafft temperature.
The Krafft temperature is the temperature at which the CMC can be achieved. This temperature determines the relative solubility of surfactant in an aqueous solution. This is the minimum temperature the solution must be at to allow the surfactant to precipitate into aggregates. Below this temperature no level of solubility will be sufficient to precipitate aggregates due to minimal movement of particles in solution. The Krafft Temperature (Tk) is based on the concentration of counter-ions (Caq). Counter-ions are typically in the form of salt. Because the Tk is fundamentally based on the Caq, which is controlled by surfactant and salt concentration, different combinations of the respective parameters can be altered. Although, the Caq will maintain the same value despite changes in concentration of surfactant and salt, therefore, thermodynamically speaking the Krafft temperature will remain constant.
Surfactant packing parameter.
Differences in shape.
The shape of a surfactant molecule can be described by its surfactant packing parameter, formula_40 (Israelachvili, 1976). The packing parameter takes into account the volume of the hydrophobic chain (formula_41), the equilibrium area per molecule at
the aggregate interface (formula_42), and the length of the hydrophobic chain (formula_43):
formula_44
The packing parameter for a specific surfactant is not a constant. It is dependent on various conditions which affect each the volume of the hydrophobic chain, the cross sectional area of the hydrophilic head group, and the length of the hydrophobic chain. Things that can affect these include, but are not limited to, the properties of the solvent, the solvent temperature, and the ionic strength of the solvent.
Cone, wedge, and cylinder shaped surfactants.
The shape of a micelle is directly dependent on the packing parameter of the surfactant. Surfactants with a packing parameter of formula_40 ≤ 1/3 appear to have a cone-like shape which will pack together to form spherical micelles when in an aqueous environment (top in figure). Surfactants with a packing parameter of 1/3 < formula_40 ≤ 1/2 appear to have a wedge-like shape and will aggregate together in an aqueous environment to form cylindrical micelles (bottom in figure). Surfactants with a packing parameter of formula_40 > 1/2 appear to have a cylindrical shape and pack together to form a bilayer in an aqueous environment (middle in figure).
References.
[13] Hamley, I.W. "The Physics of Block Copolymers" – Oxford University Press, 1998.
[14] José R. Quintana, Manuel Villacampa, Ramiro Salazar and Issa A. Katime, Thermodynamics of micellizations in solutions diluit
[15] Ian W. Hamley, Block Copolymers in Solution: Fundamentals and Applications


Disappearance of Emanuela Orlandi

Emanuela Orlandi (born 14 January 1968) was a citizen of Vatican City who mysteriously disappeared on 22 June 1983. Sightings of Orlandi in various places have been reported over the years, including inside Vatican City, but all have been unreliable.
Disappearance.
Emanuela was the fourth of five children of Ercole and Maria Orlandi (née Pezzano). Her father was an employee of the Vatican Bank according to some reports, or an employee of the papal household according to others. In any event, the family lived inside Vatican City and the children had the free run of the Vatican gardens, according to Pietro Orlandi, Emanuela's older brother.
Orlandi was in her second year at a liceo scientifico (high school) in Rome. Although the school year had concluded, she continued to take flute lessons three times per week at the Tommaso Ludovico Da Victoria School, connected with the Pontifical Institute of Sacred Music. She was also part of the choir of the church of Sant'Anna dei Palafrenieri in the Vatican.
Orlandi usually travelled by bus to the music school. She would get off the bus after a few stops and then walk . On Wednesday 22 June 1983, Orlandi was late to class. She had asked Pietro to ride on the bus to the class, but he had other commitments. "I’ve gone over it so many times, telling myself if only I had accompanied her maybe it wouldn’t have happened", he recalled decades later. Later that day, Emanuela called home, speaking to one of her sisters. Since then, there has been no trace of the teenager, and Italian investigators have been unable to reach a conclusion about what happened to her.
She had explained her tardiness in a telephone conversation with her sister, stating that she said she had received a job offer from a representative of Avon Cosmetics. Her sister suggested she talk it over with their parents before making any decisions. According to some reports, Orlandi allegedly met with the Avon rep shortly before her music lesson. At the end of the lesson, Orlandi spoke of the job offer with a girlfriend, who then left the girl at a bus stop in the company of another girl. Orlandi was allegedly last seen getting into a large, dark-coloured BMW.
Chronology.
At 15:00 on Thursday 23 June, Orlandi's parents called the director of the music school to ask if any of their daughter's classmates had information. The police had suggested waiting because "perhaps the girl was with friends". She was officially declared a missing person that day. Over the next two days, announcements of the disappearance were published with the telephone number of the Orlandi house in the newspapers "Il Tempo", "Paese Sera" and "Il Messaggero".
At 18:00 on Saturday 25 June, a phone call was received from a youth who claimed to be a 16-year-old boy named "Pierluigi". He reported that he and his fiancée had met the missing girl in Piazza Navona that afternoon. The young man mentioned Orlandi's flute, her hair, and the glasses that the girl did not like to wear, along with other details that fit the missing girl. According to "Pierluigi", Orlandi had just had a haircut and had introduced herself as "Barbarella". He claimed she stated that she had just run away from home and was selling Avon products.
On 28 June, a man calling himself "Mario" called the family and claimed to own a bar near Ponte Vittorio, between the Vatican and the music school. The man said that a girl called "Barbara", a new customer, had confided to him about being a fugitive from home but said that she would return home for her sister's wedding. On 30 June, Rome was plastered with 3,000 posters displaying Orlandi's photograph.
On Sunday 3 July, Pope John Paul II, during the Angelus, appealed to those responsible for Orlandi's disappearance, making the hypothesis of kidnapping official for the first time. Two days later, the Orlandi family received the first of a number of anonymous phone calls. Emanuela was supposedly the prisoner of a terrorist group demanding the release of Mehmet Ali Ağca, the Turkish man who shot the Pope in May 1981. No other information was given. In the following days, other calls were received, including one from a man identified as "The American", due to his apparent accent, who played a recording of Orlandi's voice over the phone. A few hours later, in another phone call to the Vatican, the same man suggested an exchange, of Orlandi for Ağca. The anonymous interlocutor mentioned the "Mario" and "Pierluigi" of the earlier telephone calls, defining them as "members of the organisation".
On 6 July, a man with a young voice and an American accent informed the ANSA news agency of the demand for an Orlandi-Ağca exchange, asking for the Pope's participation within 20 days and indicating that a basket in the public square near the Parliament would contain proof that Orlandi was indeed in his hands. These were to have been photocopies of her music school ID, a receipt, and a note handwritten by the kidnapped girl. However, the magistrate who was overseeing Orlandi's case did not believe that there was a credible connection between Orlandi's abduction and the Pope's assailant.
On 8 July, a man with an alleged Middle Eastern accent phoned one of Orlandi's classmates saying Orlandi was in his hands and that they had 20 days to make the exchange with Ağca. The man also asked for a direct telephone line with then-Secretary of State Agostino Casaroli. The line was installed on 18 July. A total of 16 telephone calls were made by "The American" from different public telephone booths.
On the morning of 14 May 2001, the parish priest of the Gregory VII Church near the Vatican discovered a human skull of small dimensions and lacking a jaw in a bag with an image of Padre Pio in a confessional. It has not been officially identified as Orlandi's skull. Emanuela's father, Ercole, died in 2004, a month after giving his last interview.
Theories.
Over the years a number of theories regarding the motives for the crime have been broached in the Italian press.
Orlandi-Ağca connection theory.
Ağca, who once declared that Orlandi had been kidnapped by Bulgarian agents of the Grey Wolves, a Turkish ultra-nationalist, neo-fascist youth organization of which Ağca was a member, spoke about Orlandi during a prison interview with Italy's RAI state television, telling the interviewer that the girl was alive, not in danger, and living in a cloistered convent. He denied any direct knowledge of the girl's fate, though, saying that he had made "some logical deductions". With no evidence to support these claims, the case was closed in July 1997.
In mid-2000, Judge Ferdinando Imposimato, based on what he had learned about the Grey Wolves, declared that Orlandi, by then an adult, was living a perfectly integrated life in the Muslim community and that she had probably lived for a long time in Paris. He remains the only supporter of this idea and of the Orlandi-Ağca connection.
In a letter published in 2006, Ağca claimed that Emanuela Orlandi and another girl, Mirella Gregori, both of whom vanished in 1983, were abducted as part of a plan to secure his release from prison. He claimed that the girls were whisked away to a royal palace in Liechtenstein. Ağca was temporarily released from an Istanbul prison after serving 25 years in Italy and Turkey for the murder of Abdi İpekçi, a prominent Turkish journalist. However, he was quickly imprisoned again, the release seemingly a "mistake". Ağca was permanently released from a Turkish prison in January 2010.
On 9 November 2010, Ağca was interviewed by state television in Turkey-TRT's "Kozmik Oda Program" for the first time since his release the preceding January. In that interview, as well as declaring that the Vatican organized the assassination attempt, he claimed that Orlandi was kept as a prisoner by the Vatican (for Ağca) and was then living in a Central European country as a nun in a Catholic monastery. He added that Orlandi's family could see their daughter whenever they liked, but that she was not allowed to leave the monastery.
Organised crime theory.
In 2011, the former Banda della Magliana member Antonio Mancini implied that Orlandi's kidnapping was one of a number of strikes that the gang was making against the Vatican in order to force the restitution of large amounts of money they had lent to the Vatican Bank through Roberto Calvi's Banco Ambrosiano. On 14 May 2012, Italian police opened the tomb of gangster Enrico De Pedis (1954–1990) and took DNA samples, according to some reports at that time. An anonymous call to an Italian television programme in 2005 said it contained evidence that would help the police explain Orlandi's disappearance, and in 2008 a former girlfriend of De Pedis said that De Pedis had once confessed to her that he had kidnapped Orlandi. No clues were found in the tomb linking De Pedis to Emanuela.
Vatican sex scandal theory.
In May 2012, when interest in the case was renewed, leading police to search the De Pedis tomb, 85-year-old exorcist Father Gabriele Amorth claimed that Orlandi was kidnapped by a member of the Vatican police for sex parties and then murdered. Amorth claimed that officials of an unnamed foreign embassy were involved as well.
Other public activity.
On 6 April 2007, in a Good Friday sermon in St. Peter's Basilica, Rev. Raniero Cantalamessa advised the congregation to make amends for sins before dying. He said: "Don't carry your secret to the grave with you!" This provoked speculation that he was suggesting someone at the Vatican held information about Orlandi's disappearance. Vatican spokesperson Rev. Federico Lombardi issued a statement that detailed Vatican cooperation with civil investigators over the years and said the Church had no objection to the opening of the De Pedis tomb, which was then being discussed. It said: "As far as we know, there is nothing hidden, nor are there 'secrets' in the Vatican to reveal on the subject. To continue to assert it is completely unjustified; also, we reiterate, yet again, all the material from the Vatican was handed over, in its time, to the investigating magistrates and to police authorities."
In October 2018, remains found during renovation work on the Holy See's Embassy to Italy in Rome were the subject of speculation related to the Orlandi affair. An attorney for the Orlandi family objected to the media attention. She said: "We have no idea why the association with Emanuela was made... We’re still asking ourselves why you’d find some bones and immediately assume they were Emanuela’s." Test results released on 1 February 2019 showed they were the remains of a Roman man who died between 190 and 230 AD.
On 10 July 2019, It was announced that the Vatican would be opening two tombs inside Vatican City which would then be examined by forensic anthropologist Giovanni Arcudi. The tombs were the "Tomb of the Angel" meant to contain the remains of Princess Sophie of Hohenlohe-Waldenburg-Bartenstein and the adjacent one which was meant to contain the remains of Duchess Charlotte Frederica of Mecklenburg-Schwerin. The exhumations took place on 11 July 2019. Neither Emanuela's body nor the bodies of the two princesses said to be buried there were found. The Vatican is currently conducting an investigation into the whereabouts of the princesses' remains.
According to a report on 13 July 2019, the Vatican announced that two sets of bones had been found near the tombs of the two princesses, raising speculation that one might be the remains of Orlandi. The bones were discovered as staff probed other locations to which the princesses’ remains may have been moved within the cemetery of the Pontifical Teutonic College. Further inspection of the site revealed two ossuaries placed beneath the floor of an area inside the college, closed by a trap door.
Reports by numerous news media outlets stated on 20 July 2019 that the tombs had actually found to be empty. According to the BBC for example, that first July 2019 search "only deepened the mystery as even the bones of two princesses thought to be there were missing". The same finding was reported by other news outlets too, including The Guardian.
Thousands of human bones belonging to dozens of bodies were, however, found on 20 July, in the underground ossuaries at the Teutonic College. Forensic investigators were to analyse the remains and were expected to use carbon-14 methods to obtain a rough estimate of their age.


Tideglusib

Tideglusib (NP-12, NP031112) is a potent, selective and irreversible small molecule non-ATP-competitive glycogen synthase kinase 3 (GSK-3) inhibitor.
Other GSK inhibitors.
There are few classes of GSK-inhibitors, including lithium
(Martinez et al., 2011), the small peptide L803mts10, and members
of the thiazolidinedione family, containing non-competitive
inhibitors of GSK-3, such as TDZD-8 (Shapira et al., 2007) or
Tideglusib® (Noscira, Madrid, and Spain), the latter having an
irreversible inhibitory effect on GSK-3 (del Ser et al., 2013). The
inhibition of the GSK-3 pathways through distinct mechanisms has
been associated with a wide range of adverse reactions, ranging
from mild, such as vertigo—or diarrhea (del Ser et al., 2013)—to
very severe, such as hypoglycemia—or tumorigenesis (Martinez
et al., 2011). The use of Tideglusib specifically was associated with
mild-moderate adverse reactions, which included transient increases
in serum creatine kinase, ALT—or gGT—diarrhea, nausea, cough,
fatigue, and headache (del Ser et al., 2013). In a phase-IIa clinical
trial, the treatment was discontinued in 35% of all the active subjects,
mainly due to adverse reactions (del Ser et al., 2013).
Potential applications.
Tideglusib is under investigation for multiple applications:


True Love Ways

"True Love Ways" is a song attributed to Norman Petty and Buddy Holly, and recorded with the Dick Jacobs Orchestra in October 1958, four months before the singer's death. It was first released on the posthumous album "The Buddy Holly Story, Vol. 2" (Coral 57326/757326), in March 1960. The song was a hit in Britain in 1960, reaching number 25 on the pop singles chart. In a 1988 re-release of the recording by MCA, the single reached no. 65 on the UK singles chart in a 5 week chart run.
In the extended version of the song, in the first ten seconds Holly can be heard preparing to sing. The audio starts with audio saying "Yeah, we're rolling." A piano player and a tenor saxophone player play some notes, and Holly mutters, "Okay," and clears his throat. The producer yells, "Quiet, boys!" to everyone else in the room, and at the end of the talkback, the producer says, "Pitch, Ernie", to signal the piano player to give Holly his starting note, a B-flat.
Along with It Doesn't Matter Anymore, Raining in My Heart, and Moondreams, this song was recorded at Holly's last recording session before his death on February 3, 1959.
The session took place at the Pythian Temple on October 21, 1958. The musicians were Al Caiola (guitar); Sanford Block (bass); Ernie Hayes (piano); Doris Johnson (harp); Abraham Richman (saxophone); Clifford Leeman (drums); Sylvan Shulman, Leo Kruczek, Leonard Posner, Irving Spice, Ray Free, Herbert Bourne, Julius Held and Paul Winter (violins); David Schwartz and Howard Kay (violas); and Maurice Brown and Maurice Bialkin (cellos).
Although Holly's widow, Maria Elena Holly, claims that the song was written for her as a wedding gift, a listing of producer Norman Petty's productions claims that Vi Petty, Norman's wife, recorded the first version of this song on June 4, 1958—two weeks prior to Buddy's engagement with Maria. Holly biographer Bill Griggs points out that the melody borrows heavily from the gospel song "I'll Be All Right," a favorite of Holly's, and one that would be played at his funeral in 1959. According to Griggs, the framework of the melody was written by Buddy, with the remainder, and lyrics, added by Petty. On April 29, 2011, Mrs. Holly unveiled the never-before-seen "True Love Ways" photo of their wedding kiss, now displayed at P.J. Clarke's above Table 53, the table where they became engaged while on their first date, on June 20, 1958.
Two albums by Buddy Holly have used the title of the song. The 1989 Telstar album reached no. 8 on the UK album chart. The 2018 Decca album with the RPO reached no. 10 on the UK album chart.
Mickey Gilley version.
Mickey Gilley, country singer, released a successful cover version in 1980 (during the height of his popularity). Gilley's version reached the No. 1 spot on the "Billboard magazine" Hot Country Singles chart in July 1980.
Cliff Richard version.
British pop singer Cliff Richard released his cover as the lead single from his "Dressed for the Occasion" album in April 1983. The recording is of a live performance at the Royal Albert Hall in 1982 with the London Philharmonic Orchestra. Richard's version reached No. 8 on the UK Singles Chart and was a hit in several other countries.
Other notable versions.
Anna Nalick version 2019


The Court, Stanton Drew

The Court in Stanton Drew, Somerset, England dates from 1753 and is a Grade II* listed building. It is now used as a nursing home. The walls and piers around this property are themselves Grade II listed. It is now used as a nursing home.
History.
The house was built in 1753 and incorporated some features from a previous building. It underwent significant remodelling in the 19th century.
Architecture.
The limestone front of the three-storey building has five bays. The central doorway has doric pilasters supporting a segmental pediment.
The of grounds include mature trees and herbaceaous borders. There is also a vegetable garden and fruit trees. It is opened for the National Gardens Scheme.
Nursing Home.
The building has been converted into a nursing home. It was inspected by the Care Quality Commission in November 2015 and rated as requiring improvement. In 2018 the CQC rated the home as good.


Mike Wallace Is Here

Mike Wallace Is Here is a 2019 biographical documentary film directed by Avi Belkin. It was produced by Rafael Marmor, Peggy Drexler, John Battsek, Avi Belkin, and Chris Leggett, under the banner of Drexler Films, Delirio Films and Rock Paper Scissors Entertainment. The film follows the life and career of American journalist Mike Wallace, using never-before-seen archival footage of the journalist preparing for and speaking about his work.
The film premiered on 27 January 2019 at the 2019 Sundance Film Festival, where it was nominated for Grand Jury Prize – Documentary. After the premiere, the film was nominated for Best Documentary at Sheffield Doc/Fest, Docaviv, and Cleveland International Film Festival. The film has received positive reviews from film critics, with review-aggregation websites Rotten Tomatoes and Metacritic giving a 94% and 73% of positive reviews, respectively.
Synopsis.
"Mike Wallace Is Here" follows the career of American journalist Mike Wallace. It depicts Wallace as he starts the show "60 Minutes" and experiments with its format. He interviews celebrities including Bill O'Reilly, Donald Trump, Ruhollah Khomeini, and Oprah Winfrey, shown through archive footage of the show.
Cast.
Other appearances:
Production.
Director Avi Belkin told "From the Grapevine": "I had this idea. I wanted to do a Mike Wallace interview with Mike Wallace. But Mike was obviously dead, so I had an idea of doing this through the archives". He approached CBS News, producer of "60 Minutes", which provided Belkin with more than 1,400 hours of archival footage, including "never-before-seen footage of Wallace prepping for interviews, chatting with colleagues and pontificating about his life's work". This was the first time CBS News had allowed someone to use their "60 Minutes" archival footage. Belkin spent several months watching Wallace's interviews, writing down the ideas he had, and then spent about a year editing the film alongside Billy McMillin and his team.
Belkin said he did not plan to explore Wallace's personal life. He explained:
The film title refers to the legendary fear that Wallace's name evoked in his interview subjects. According to Belkin, these were "the four most-dreaded words in the English language back then". The title also hints to the ongoing legacy that Wallace leaves with the viewing of this archival footage.
Release.
"Mike Wallace Is Here" premiered at the 2019 Sundance Film Festival on 27 January 2019. It was nominated for Grand Jury Prize – Documentary. The film had a special screening on 16 July 2019 in the United States.
Box office.
In its opening weekend, "Mike Wallace Is Here" was screened in three theatres, grossing $19,437 with an average of $6,479 per theatre. In its second weekend, the film was screened in 21 theatres, grossing $49,129 with an average of $2,339 per theatre. In its third weekend, the film was screened in 32 theatres, grossing $38,550 with an average of $1,205 per theatre. In its fourth weekend, it grossed $51,935, with an average of $1,332 per theatre.
Critical reception.
On review aggregator Rotten Tomatoes, the film holds an approval rating of 95% based on 91 reviews, and an average rating of 7.5/10. The website's critical consensus reads, "As solidly compelling as its subject's best reporting, "Mike Wallace Is Here" is a worthy tribute and an engrossing look at the changing landscape of modern news". Metacritic, which uses a weighted average, rated the film 73 out of 100 based on 22 critics, indicating "generally favorable reviews".
Richard Roeper of "Chicago Sun-Times" wrote: "This is a time capsule—an expertly crafted time capsule—of an astonishing career". Leah Pickett of "Chicago Reader" wrote: "Director Avi Belkin employs many creative strategies to reveal the inner workings of Mike Wallace, the formidable reporter best known for grilling celebrities and political dignitaries on "60 Minutes"". Josh Modell of "The A.V. Club" wrote: 'To be blunt—which Wallace, who died in 2012, always was—Mike Wallace Is Here is fascinating but scattered, and never quite decides what its target should be". Amy Nicholson of "Variety" wrote: "As Belkin's brisk and compelling documentary fades to black, the director seems to hope that the Wallace quotation audiences cling to isn't one of his fanged questions, but his optimism for the profession to which he dedicated his life".
Lisa Jensen of "Good Times" criticised the film, writing that "Belkin never really discovers the man behind the public persona. Nor does he find (in what must have been hundreds of hours of footage) any particular 'aha!' moment with an interview subject that would cap Wallace's legacy". Norman Wilner of "Now" wrote: "Maybe that's Belkin's point: that contemporary journalism has settled for easily digestible, context-light sound bites rather than discourse or dialogue that's intended to find the inarguable truth of a thing". Nora Lee Mandel of "Film-Forward" wrote: "Director Avi Belkin's debut English-language feature documentary opens with its most intriguing setup and then takes a while to reach that insight again".
Accolades.
In 2019, the film won Video Source Award awarded by International Documentary Association. "Mike Wallace Is Here" received various nominations including, Grand Jury Prize – Documentary at Sundance Film Festival, and Sheffield International Documentary Festival. The film was also nominated for Best International Film at the Docaviv International Documentary Film Festival, Best Documentary at the Cleveland International Film Festival, Phoenix Award at Film Festival Cologne, Best Archival Documentary, and Best Biographical Documentary at the Critics' Choice Movie Award, and Outstanding Achievement in Editing at Cinema Eye Honors.


Where-to-be-born Index

The Economist Intelligence Unit’s where-to-be-born index (previously called the quality-of-life index, abbreviated QLI) attempts to measure which country will provide the best opportunities for a healthy, safe and prosperous life in the years ahead. It is based on a method that links the results of subjective life-satisfaction surveys to the objective determinants of quality of life across countries along with a forward-looking element.
Methodology.
The index calculated for 2013 includes data from 80 countries and territories. The survey used ten quality of life factors along with forecasts of future GDP per capita to determine a nation's score.
The life satisfaction scores for 2006 (on a scale of 1 to 10) for 130 countries (from the Gallup Poll) are related in a multivariate regression to various factors. As many as 11 indicators are statistically significant. Together these indicators explain some 85% of the inter-country variation in life satisfaction scores. The values of the life satisfaction scores that are predicted by the indicators represent a country's quality of life index. The coefficients in the estimated equation weight automatically the importance of the various factors. The estimated equation for 2006 can be utilized to calculate index values for year in the past and future, allowing for comparison over time as well across countries.
The independent variables in the estimating equation for 2006 include:
1988 rankings.
The original quality-of-life index was released in 1988. It included a "philistine factor" for a lack of culture and a "yawn index" which measured how boring a country might be despite all its other advantages.


The Consultant Pharmacist


Los Angeles Jewish Home

Los Angeles Jewish Home is a non-profit provider for senior healthcare services in Los Angeles, California. It is also commonly known as “the Jewish Home,” or simply “the Home.” Over the past century, the organisation has mainly focused on providing their healthcare services for the seniors throughout the greater Los Angeles area.
The Jewish Home's Reseda campuses offer independent living, residential care, skilled nursing care, short-term rehabilitation, and Alzheimer's disease and dementia care. The Home's Gonda Healthy Aging Westside Campus in Playa Vista offers independent living as well as assisted living and memory care.
History.
On Passover, 1912, the Los Angeles Jewish Home began when a small group of neighbors gave shelter to five homeless Jewish men.
In 1916, the first permanent structure for the Home was purchased in the Boyle Heights section of downtown Los Angeles. The Jewish Home made plans for a facility in the San Fernando Valley of Los Angeles. This facility became known as the California Home for the Aged.
In the 1940s and 1950s, the Home built new facilities and senior residences in Reseda in the San Fernando Valley. The new site became known as the Grancell Village Campus.
In 1972, the California Home for the Aged was renamed Menorah Village. Four years later, the original Jewish Home for the Aged moved to a new location in the Reseda area of the San Fernando Valley. The two San Fernando Valley locations merged, becoming the Jewish Home for the Aging of greater Los Angeles and, ultimately, the Los Angeles Jewish Home.
Throughout the 1980s and 1990s, the Home constructed new clinics, residences, and facilities as the resident population grew. The Victory Boulevard Campus was named the Eisenberg Village Campus.
Expansions since 2000:
2002: Opening of the Goldenberg•Ziman Special Care Center for Alzheimer's disease and age-related dementia.
2004: Skirball Hospice began providing end-of-life care, and the Jewish Home Center for Palliative Medicine, focuses on the needs of those with chronic medical conditions.
2007: The Joyce Eisenberg-Keefer Medical Center on the Grancell Village Campus opened. The complex had an acute psychiatric hospital, 239 nursing beds, and a geriatric research center.
2010: Opening of the Fountainview at Eisenberg Village, the Home's first Continuing Care Retirement Community (CCRC). The community has 108 residences for independent senior living.
Introduction of Jewish Home Care Services, a home health agency offering nursing, personal care assistance, and other assistance to seniors living at home.
2012: Brandman Centers for Senior Care (BCSC), a Program of All-inclusive Care for the Elderly (PACE), opened.
2017: Opening of the Gonda Healthy Aging Westside Campus featuring Fountainview at Gonda Westside, a CCRC community in the Playa Vista area of West Los Angeles. It contains 175 independent living Brandman Residences and 24 residential units for assisted living and memory care.
Services Currently Offered.
Senior care services of the Los Angeles Jewish Home include:
Community-based Program of All-inclusive Care for the Elderly (PACE)
The Brandman Centers for Senior Care (BCSC) provide quality medical care that promotes independence for seniors through PACE, which
coordinates and provides all needed preventive, primary, acute, and long-term care services to older adults so they may live at home in their communities. The PACE model of care revolves around a fully integrated, interdisciplinary team of doctors, nurses, therapists, social workers, dietitians, drivers, and others who provide direct care and services to meet each program participant's needs.
Home Health
Registered nurses, vocational nurses and, certified home health aides are partnered with physical, occupational, and respiratory therapists to care for seniors within their home.
Skirball Hospice
Hospice provides end-of-life care to individuals with a life-limiting illness in their home or in the Jewish Home's Skirball Hospice.
Palliative Medicine
Palliative Medicine provides pain and symptom management for adults with chronic conditions.
Acute Psychiatric Care
The Auerbach Geriatric Psychiatry Unit focuses on providing care for various conditions, such as bipolar disorder, depression, and schizophrenia.
Independent Living
On site at the Jewish Home's Fountainview at Eisenberg Village in Reseda and the Fountainview at Gonda Westside in Playa Vista.
Assisted Living
On site at the Jewish Home's Reseda and Playa Vista campuses.
Residential Care
On site at the Jewish Home's Reseda campuses.
Skilled Nursing Care
On site at the Mark Taper Skilled Nursing Building, the Max Factor Family Foundation Building and the Joyce Eisenberg-Kiefer Medical Center on the Jewish Home's Reseda campuses.
Short-Term Rehabilitation
The Ida Kayne Transitional Care Unit helps seniors transition back to daily life after an illness, injury, medical procedure, or hospital stay.
Alzheimer's, Dementia, and Memory Care
The Goldenberg•Ziman Special Care Center provides nursing care for seniors with Alzheimer's disease and age-related dementia.
Annual Events.
“World’s Largest” Mother's Day Celebration
The Los Angeles Jewish Home hosts a Mothers Day celebration each year for each mother, grandmother, great-grandmother and great-great-grandmother. The celebration began over two decades ago.
Celebration of Life: Reflections Gala
This is an annual event for the community which celebrates the leadership, donors and supporters of the Home's programs.
Longest Day of Golf
Annually, the Home asks those from the local community to participate in a day-long golfing event, to raise money for the home.
Sarnat Symposium for Geriatric Care
The Sarnat Symposium brings in speakers each year to share their insights, research findings, and experience with social workers and other professionals who care for seniors.
Notes.
Abram, Susan, “A century of love and care celebrated at Los Angeles Jewish Home,” Los Angeles Daily News, January 8, 2012. https://www.dailynews.com/2012/01/08/a-century-of-love-and-care-celebrated-at-los-angeles-jewish-home/
Bartholomew, Dana, “Los Angeles Jewish Home in Reseda offering new medical care for seniors,” Los Angeles Daily News, March 19, 2013. https://www.dailynews.com/2013/03/19/los-angeles-jewish-home-in-reseda-offering-new-medical-care-for-seniors/
Berrin, Danielle, “Molly Forrest plans the future at the Los Angeles Jewish Home,” Jewish Journal, Oct 23, 2014. https://jewishjournal.com/cover_story/134353/
Day, Nellie, “Los Angeles Jewish Home Begins Constructions on $100M Fountainview at Gonda,” ReBusiness Online, September 12, 2014. https://rebusinessonline.com/los-angeles-jewish-home-begins-construction-on-100m-fountainview-at-gonda/
Eckerling, Debra L., “Temple Judea Students Enjoy ‘Respecting Elders’,” Jewish Journal, December 19, 2018. https://jewishjournal.com/news/los_angeles/community/291378/temple-judea-students-enjoy-respecting-elders/
Fountainview at Eisenberg Village. (n.d.) Continuing Care Retirement Community. Retrieved 1-2-19 from http://www.fountainviewjha.com/about/continuous-care-retirement
Fountainview at Gonda. (n.d.). Innovative and Luxurious Apartments for Independent Living. Retrieved 1-2-19 from http://www.fountainviewgonda.com/about-us/
Haynes, Karima A, “Jewish Home for the Aging Will Launch $72 Million Campaign,” Los Angeles Times, March 11, 2000. http://articles.latimes.com/2000/mar/11/local/me-7746
Healthcare for People. (n.d.). Jewish Home Care Services. Retrieved 1-2-19 from https://www.healthcare4ppl.com/home-health/california/encino/jewish-home-care-services-059170.html
Jewish Museum of the American West. (2018). The Los Angeles Jewish Home for the Aging began as the Hebrew Sheltering Society – 1908. Retrieved 1-2-19 from: http://www.jmaw.org/jewish-home-los-angeles/
Leading Age California. (Oct 5, 2011). Handy to Lecture at Los Angeles Jewish Home's 14th Annual Sarnat Symposium. Retrieved 1-3-19 from https://leadingageca.wordpress.com/2011/10/05/handy-to-lecture-at-los-angeles-jewish-homes-14th-annual-sarnat-symposium/
Los Angeles Jewish Home. (n.d.). Short-Term Rehabilitation. Retrieved 1-2-19 from http://www.lajh.org/care/place-to-live/short-term/ida-kayne-transitional-care-unit/
Los Angeles Jewish Home. (n.d.). Skilled Nursing. Retrieved 1-2-19 from http://www.lajh.org/care/place-to-live/long-term/skilled-nursing/
Nelson Hardiman. (n.d.) Events. Retrieved 1-3-19 from https://www.nelsonhardiman.com/events/senior-care-2028-whats-ahead-for-medicare-health-policy-and-delivery-of-care-for-aging-seniors/
PR Newswire. (Oct 13, 2015). Los Angeles Jewish Home to Honor CEO-President Molly Forrest at "Celebration of Life: Reflections 2015" Annual Gala. Retrieved 1-3-19 from https://www.prnewswire.com/news-releases/los-angeles-jewish-home-to-honor-ceo-president-molly-forrest-at-celebration-of-life-reflections-2015-annual-gala-300158924.html
Ritsch, Massie and Laura Loh, “A Big Day in the Sun for Southland Moms,” Los Angeles Times, May 13, 2002. http://articles.latimes.com/2002/may/13/local/me-mother13
Seniors Housing Business. (June 22, 2018). LeadingAge California Selects Los Angeles Jewish Home CEO Molly Forrest as Chair. Retrieved 1-3-19 from http://www.seniorshousingbusiness.com/the-latest-news/leadingage-california-selects-los-angeles-jewish-home-ceo-molly-forrest-as-chair
Skirball Hospice. (n.d.). Are You Considering Hospice Care? Retrieved 1-2-19 from http://skirballhospice.org/about/default.asp
Skirball Hospice. (n.d.). Skirball Hospice History. Retrieved 1-2-19 from http://skirballhospice.org/about/history.asp
Skirball Hospice. (n.d.). Palliative Medicine for Pain and Symptom Management. Retrieved 1-2-19 from http://skirballhospice.org/services/palliative-care.asp
Suffolk. (n.d.). Fountainview at Eisenberg Village. Retrieved 1-2-19 from https://www.suffolk.com/projects/fountainview-eisenberg-village-reseda-california
Torok, Ryan, “Moving & Shaking,” Jewish Journal, April 5, 2018. https://jewishjournal.com/news/los_angeles/moving-shaking/232783/moving-shaking-march-lives-big-brothers-seder/
Ward Biederman, Patricia, “Home Has Care in Mind,” Los Angeles Times, April 14, 2002. http://articles.latimes.com/2002/apr/14/local/me-memory14


Therapeutic Advances in Drug Safety

Therapeutic Advances in Drug Safety is a peer-reviewed open-access medical journal published by SAGE Publishing covering research on drug safety. It was established in 2010 and the editor-in-chief is Arduino A. Mangoni (Flinders University).


Spotlight (Marshmello and Lil Peep song)

"Spotlight" is a song by American music producer Marshmello and singer and rapper Lil Peep. It was released on January 12, 2018, as a tribute to Peep following his death. Marshmello initially had no plans to release the song until Peep's mother made said request. The song is the rapper's first posthumous release.
Background.
Marshmello was among the first artists in the dance music community to comment on Peep's death. In a series of tweets, Marshmello says Peep was "the nicest person" and that they had spoken about a collaboration a week before. "Peep was the nicest person. Hanging out with him, talking to him about music, the song ideas we were going to do together and touring was so amazing. Everyone will miss you man," he wrote. On November 20, 2017, Marshmello worked a live tribute into his performance at GoldRush Festival in Arizona, by mixing the rapper's song "Beamer Boy" into his set, as a large image of Peep reading "RIP" appeared on the screen behind him.
On December 20, 2017, it was announced that Marshmello would release the song on January 12, 2018. A spokesperson said the pair began working on the song before Peep died, and that it will be accompanied by a music video. While some fans questioned Marshmello's decision, since other artists are withholding their work with Peep, he revealed that Peep's mother encouraged him to release it as a tribute to her son. He wrote in a tweet: "I didn't plan on releasing the song until peeps mom reached out and told me she wanted her sons music to come out...what am I supposed to do?" On January 10, 2018, Marshmello unveiled the song's title and artwork on social media. He later uploaded a brief audio preview of the track on social media.
Marshmello praised Peep's enthusiasm for making music in a statement, writing: "Peep brought an excitement to music that was unparalleled to anybody I've ever met. We started an idea together, that unfortunately we were never able to officially finish together. When I listen to this track now I get chills wishing he could hear it. This record is dedicated to Peep's mother, family, friends and his fans. Gus will live forever through his music and that is something we should all be extremely thankful for." Peep's mother added that she was appreciative that Marshmello released the song since it continued "to allow Peep's voice to be heard through his art."
Critical reception.
Beatrice Hazlehurst of "Paper" regarded it as "a classic example of Peep's emo garage-rap that made him so popular". Colin Joyce of "Vice" called the song a "heartbreaker", and described it as "slow-moving, but starry-eyed". He wrote that Marshmello "bends in Peep's direction" by "offering foreboding mid-aughts-emo-intro guitar line for [Peep] to sing over before launching into the skyscraper-scale drums", similar to his collaboration with Migos, "Danger", and his remix of the Future song "Mask Off". Sheldon Pearce of "Pitchfork" deemed the song "a reminder of Peep's promise as a rap-rock spitfire", with "all the urgency of the more lovestruck Peep tracks, full of obsession and contempt". Jeff Benjamin of Fuse wrote that it "honors Peep's signature trap/emo sound and his knack for brutally honest storytelling", and that "the track indicated bigger things coming for Lil Peep as he edged closer and closer to mainstream accessibility, bringing an exciting new look and sound to the scene". He noted that the song does not feature Marshmello's signature sound, and "instead plays more to Peep's trap styles". Similarly, Eric Skelton of "Complex" opined that it strays away from Marshmello's style, and "is more in line with the grungy pop-punk aesthetic Lil Peep was known for". Your EDM's Karlie Powell also wrote: "Don't expect the usual, bubbly Marshmello beat, because Lil Peep's bold style is front and center on this one." Jon Wiederhorn of CBS Radio wrote: "The melancholy track combines melodic vocals with smooth rapping and the lyrics address a painful breakup." Molly Hudelson of "Substream Magazine" opined that it is "more somber in sound than most of Marshmello's releases", and found "the themes of heartache and feeling 'all alone again' are relatable to anyone who's gone through a breakup or otherwise lost someone they loved".


Elise Matthesen

Elise Matthesen (née Krueger; born 1960) is an American essayist, journalist, poet, and fiction writer (primarily of science fiction and fantasy; she is an active supporter of the interstitial arts movement), an award-winning maker of art jewelry and a long time Bisexual Rights activist. For 13 years she was the companion of the late John M. Ford, until his death in September 2006. She lives in Minneapolis, Minnesota and is a member of the First Universalist Church there.
Early life.
Matthesen was born in Wisconsin.
Career.
She is an anorexia nervosa survivor as well as a speaker, facilitator, and activist on issues of body acceptance, bisexuality, polyamory, and issues of self-esteem. She was one of the original contributors to the groundbreaking 1991 bisexual anthology "Bi Any Other Name", has written for local GLBT magazine "Lavender", and is an active member of science fiction fandom.
In 1993 Jane Yolen published Matthesen's short story "The Stone Girl" in the Xanadu anthology together with works by Tanith Lee and Ursula K. Le Guin. In 2008 Catherine Lundoff published Matthesen's short story "Focus of Desire" in an anthology of Lesbian ghost stories.
Awards.
In 2009, Matthesen was a World Fantasy Award nominee for the "for setting out to inspire and for serving as inspiration for works of poetry, fantasy, and SF over the last decade through her jewelry-making and her 'artist's challenges'".
In 2020, she won the Hugo Award for Best Fan Artist, the first artist in a 3-D medium to do so.


Disappearance of Ludovic Janvier

Ludovic Janvier is a six-year-old French boy who went missing on <time>17 March 1983 from</time> Saint-Martin-d'Hères, a suburb of Grenoble, in the Isère département of south-eastern France. His disappearance has been linked to that of several other children in the area, collectively known as the Disparus de l'Isère (literally, the "Disappeared of the Isère"). Ludovic's whereabouts remain unknown to this day.
Disappearance.
Six-year-old Ludovic Janvier disappeared from Saint-Martin-d'Hères on Thursday 17 March 1983. He was last seen in Place de la République, on the way home with his two brothers, Jérôme (8) and Nicolas (2½). They had gone to buy cigarettes for their father sometime between 6:30 and 7:45 pm.
Investigation.
Several witnesses testified that a man wearing a construction-style hard hat, blue work overalls and black heavy-duty zip-up shoes approached the boys and said to them: "I've lost my wolf-dog. If you help me find him, I'll buy you sweets." The man allegedly asked them to separate in two different directions. Jérôme and Nicolas went one way, and the unknown man left in the other direction with Ludovic in hand. Jérôme and Nicolas returned home and told their father what had happened. Their father then informed the police.
Later that year, the clerk of a court judge in Grenoble received a phone call informing her that the child had been adopted by a new family. The anonymous correspondent claimed to have read this in the newspaper "L'Union de Reims".
On <time>23 May 1985</time>, police found the body of a child in the nearby Vercors Cave System. The body was never identified.
Aftermath.
Around 2010, Virginie – Ludovic's sister – received a phone call from a nurse at a hospital near Reims, a French city 600 km (370 miles) to the north. The nurse claimed to have seen someone resembling Jérôme, Ludovic's older brother. She recognised the now adult Jérôme after seeing him in a news report about Ludovic's disappearance.
In 2011, the Grenoble authorities announced that they were reopening Ludovic Janvier's case, as well as that of another girl in the "Disparus de l'Isère" investigation. Their disappearances were reclassified as "illegal confinement".
In 2013, Ludovic's mother appealed to the authorities in an attempt to find out whether the body of the unidentified child found in 1985 was that of her son.
In 2014, the Grenoble authorities announced that they were closing Ludovic Janvier's case. The family's lawyers, Didier Seban and Corinne Herrmann, hope to appeal this decision on the basis of witness statements which they believe have not been followed up.
In 2015, the Court of Appeal reopened the case and ordered new investigations.


W. J. Younger

William John Younger (1838-1920) was an American dentist who performed some of the earliest and most groundbreaking research in the field of periodontology.
Work in the field of periodontology.
Younger was a follower of John W. Riggs, the first American periodontist. In 1893, he was the first to consider periodontal disease an infection and was the first to discuss the possibility of "periodontal reattachment," a process in which gingival graft tissue could be removed from one site in the mouth and properly reattached to the alveolar bone.
in 1902, Younger reported the first gingival graft, in which he removed tissue "from behind the third molar" and reattached it near the canine tooth, claiming the surgery to have been a success. In the same report he first described the use of a membrane for periodontal regeneration.
Younger practiced for some time in San Francisco, California.


Almeric Paget Massage Corps

The Almeric Paget Massage Corps (later the Almeric Paget Military Massage Corps) was a British physiotherapy service during the First World War.
History.
On the outbreak of the First World War, Almeric Paget and his first wife, the American socialite Pauline Payne Whitney, offered the services of 50 trained masseuses to the British War Office. The offer was accepted and by November 1914, 50 women had been placed in military hospitals. At this time the demand for physiotherapy (or Massage and Electrical Treatment as it was known) increased and the Pagets were asked to open a day centre in London to relieve pressure on the military hospitals in London. Lady Alexander Paget offered her house at 55 Portland Place and soon over 200 men were being seen at the clinic seen every day. By now the number of women employed in the corps was over 200 and soon they became attached to the staff of most military hospitals with a further 120 masseuses employed.
In 1916 the work of the Corps was favourably inspected by Alfred Keogh, the Director General of the Army Medical Service. This inspection had two direct outcomes. Firstly the name of the Corps was amended to become the Almeric Paget Military Massage Corps and, secondly, the Corps was asked to manage physiotherapy services in all military hospitals and convalescent camps. As part of the second the services provided would be paid for by a government grant, until then the Corps and the services it provided had been privately funded by the Pagets and by donations.
Until 1917 all Corps members were UK based but from January 1917 onwards members could volunteer to work overseas and by the end of the war 56 members of the Corps had or were working abroad in Italy and France.
By the end of the war over 2,000 masseuses and masseurs were at work and just under 3,400 had been engaged by the Corps at some point during the war.
The Corps came to an end in January 1919 when a formal Military Massage Service was formed under the auspices of the Army and Pensions Massage Association. All members of the Corps were given the option to join the new Service which was controlled jointly by the War Office and the Ministry of Pensions.


Doug Caine

Douglas Caine is an American psychologist and an addiction treatment professional, he is the founder of the rehabilitation facility Sober Champion. Many of his clients are Hollywood celebrities and the wealthy.
About.
In 2005, Caine opened a boutique sober coaching firm called Sober Champion. In 2007, he traveled to New York City and London, trained staff there and opened UK Sober Champion and New York Sober Companion. More recently, he traveled to Chicago and launched a local operation: "Chicago Sober Champion".
After completion of his doctorate in Clinical Psychology, Dr. Caine opened a non-traditional mental health counseling practice in Santa Monica. Currently, he greets a wide variety of conditions in private practice, "Connect With Douglas".


Elisha Perkins

Elisha Perkins (January 16, 1741September 6, 1799) was a United States physician who created his own fraudulent medical device, the Perkins Patent Tractors. Although they were made of steel and brass, Perkins claimed that they were made of unusual metal alloys. Perkins claimed his rods cured inflammation, rheumatism and pain in the head and the face. He applied the points on the aching body part and passed them over the part for about 20 minutes. It was later subject of the first placebo research.
Biography.
Elisha Perkins was born 1741 in Norwich, Connecticut. He was educated by his father Joseph Perkins in Plainfield, Connecticut, where he later practiced medicine with success. When the American Revolutionary War broke out, Elisha Perkins served as a surgeon for the Continental Army during the Battle of Bunker Hill in the Siege of Boston. During the late 18th century, the progression of medicine due to the Enlightenment increased the consumer demand for new therapies, such as therapeutic devices and inventions. Consequently, around 1795–96, Perkins invented his "Tractors", for which he took out a 14-year patent on February 19, 1796. The tractors consisted of two 3-inch metal rods with a pointed end. Although they were made of steel and brass, Perkins claimed that they were made of unusual metal alloys. Perkins claimed his rods cured inflammation, rheumatism and pain in the head and the face. He applied the points on the aching body part and passed them over the part for about 20 minutes. Perkins claimed they could "draw off the noxious electrical fluid that lay at the root of suffering".
The Connecticut Medical Society condemned the tractors as "delusive quackery", and expelled Perkins from membership on the grounds that he was "a patentee and user of nostrums". Perkins nevertheless managed to convince three US medical faculties that his method worked. In Copenhagen, Denmark, twelve surgeons at the royal Frederiks Hospital also began to support the method. Even George Washington bought a set. Other physicians' criticisms were met with charges of elitism and professional arrogance. Perkins boasted of 5,000 cured cases. The cures were certified to by eight professors, forty physicians, and thirty clergymen. Of the purchase made by Washington, Perkins' son, Benjamin Perkins, said that the "President of the United States, convinced of the importance of the discovery from experiments in his own family, availed himself of its advantages by purchasing a set of the Tractors for their use."
Benjamin Perkins was a bookseller and introduced the tractors to London. There a Perkinsian Institution for the benefit of the poor was founded under the presidency of Lord Rivers. In 1798, Benjamin published "The Influence of Metallic Tractors on the Human Body". In October 1799, an advertisement in "The Times" said that "The tractors, with every necessary direction for using them in Families, may be had for 5 guineas the set, of Mr. Perkins, of Leicester Square; or of Mr. Frederic Smith, Chemist & Druggist, in the Haymarket".
Aylmer Bourke Lambert, a British botanist, is on record as having written in January 1800 to Richard Pulteney of Blandford (now Blandford Forum), in the English county of Dorset, as follows:
"I breakfasted with Sir Joseph [Banks] on Monday morning who is recovered from the Gout and in high Spirits. We had a good deal of laughing about the Tractors. Perkins has published several Cases communicated by my Father, and presented me with a copy of his Book."
Shortly before his death Elisha Perkins also invented purported antiseptic medicine and used it for dysentery and sore throat. Perkins also claimed to have discovered a cure for yellow fever. This consisted of vinegar with muriate of soda which he tested in New York City during an outbreak in 1799. The cure had no effect and Perkins contracted the fever and died.
After Perkins' death, British physicians began to have doubts about his tractors. In 1799, Dr. John Haygarth conducted a test in which he treated five rheumatic patients with wooden tractors that were made to resemble the metallic ones. Four of them reported that the pain was relieved. The next day the patients were treated with metallic tractors with the same results. Dr. Haygarth reported on his findings in a publication entitled "On the Imagination as a Cause & as a Cure of Disorders of the Body". Attempts to use the tractors to cure animals proved futile.
By this time, Perkins had numerous influential supporters and the sale of the tractors continued. In 1803, Thomas Green Fessenden published his poem "Terrible Tractoration" in favor of Perkins and as a satire on other physicians. Perkins' son died in 1810. After that the popularity of the tractors began to wane.
In 1932, Morris Fishbein commented that "[u]nfortunately no one has yet been able to determine whether Elisha Perkins was merely a somewhat deluded physician or actually a great impostor."
Perkins was the father of Sarah Bushnell Perkins, who is remembered for her pastels.


Beauxart Gardens, Texas

Beauxart Gardens is an Unincorporated community in eastern Jefferson County, Texas. It is located between U.S. Highway 69, U.S. Highway 96, U.S. Highway 287, and Spur 93. The community is six miles (10 km) southeast of downtown Beaumont and slightly to the west of Southeast Texas Regional Airport. It is across a highway from the Unincorporated community of Viterbo.
At one time residents of Nederland and Viterbo used sites in Beauxart Gardens for rice farming. The Federal Government of the United States developed Beauxart Gardens during the Great Depression. The community was named for its location between Beaumont and Port Arthur. The town plat, filed in 1934, was approved by the Resettlement Administration in 1935. The tract housed 50 families. Each house had three to six rooms and three and one half acres of land; each household was permitted to use the land in any manner. Many of the residents held part-time jobs at refineries. For the remainder of each year, they worked in the Beauxart Gardens government truck farm. On August 10, 1942, a voting precinct was established in the community.


Balanoposthitis chronica circumscripta plasmacellularis


James Titcombe

James Roger Titcombe OBE is Patient Safety Specialist at Datix Limited. He was previously, from October 2013 to March 2016, the National Advisor on Patient Safety, Culture & Quality for the Care Quality Commission.
Earlier in his career he was project manager in the nuclear industry. His baby son Joshua died at University Hospitals of Morecambe Bay NHS Foundation Trust nine days after his birth at Furness General Hospital in November 2008. James refused to accept the initial explanations he and his wife were given for Joshua's death and made an official complaint about his treatment. He got no apology from the Trust until nearly 17 months after the event. In March 2011 a police investigation into Joshua's death was launched. It later included the deaths of 18 other babies and two mothers at the hospital. There was also an independent investigation by Dr Bill Kirkup into the maternity unit. The Parliamentary and Health Service Ombudsman eventually investigated the way his complaints had been dealt with and made recommendations which Titcombe supported, "in particular the need for honestly and robust incident investigation following avoidable harm or death in the NHS" using techniques for which staff were properly trained.
He draws heavily on his own experience in speaking about quality improvement in the NHS. He reports sadly that "I'll Datix you", is used as a threat in argumentative situations in the NHS.
He was appointed an OBE in the Queen's Birthday Honours 2015 for services to patient safety.
In December 2015, his book "Joshua's Story: Uncovering the Morecambe Bay NHS Scandal" was published.


HowNutsAreTheDutch

"How Nuts Are The Dutch" is an online research platform that became established on 13 December 2013 in the Netherlands. HowNutsAreTheDutch has been designed by researchers from the University of Groningen to support self-measurement of mental health for the entire population of The Netherlands. The project shows how crowdsourcing can be used for studying mental health in the general population. HowNutsAreTheDutch ( in Dutch) provides automatic personalized feedback on filled-out questionnaires to provide participants with more basic insight in their mental health, including a comparison with the scores of other participants. HowNutsAreTheDutch is meant to reduce mental health stigma and to promote a discrete categorization of mental health, by showing that all people have both personal strengths and weaknesses, and that most psychological characteristics are distributed continuously in the population. A background goal is to develop and evaluate personalized interventions to improve mood-related problems and social-emotional functioning. In the first year 13000 inhabitants of the Netherlands and Belgium participated.
Background.
The HowNutsAreTheDutch name has been reported to be inspired by the Pandora foundation. The Pandora foundation was a Dutch patient organization for people with mental health problems, which used posters with tongue-in-cheek sayings to inform the public and reduce mental health stigma. The HowNutsAreTheDutch project was created by scientists from different fields, including computer sciences, psychiatric epidemiology, psychology, and mathematics.
Diary Study.
Since the summer of 2014 HowNutsAreTheDutch provides an automated electronic diary study. This is also known as the ecological momentary assessment methodology. With this diary study participants can monitor their emotions, behaviour, somatic symptoms, and well-being over 30 days (3 times a day), which results in a personal network model. There is no financial compensation for taking part in the research; instead, if participants fill in the diary often enough they get a personal, automatically generated report in return. The web-platform uses automated vector autoregression models to determine cause-effect relationships between the measured features in the time series data. Results evidence substantial between-person variability in within-person associations. The diary study featured in the Dutch magazine "Psychologie" as a Quantified Self tool. Some researchers coupled data from commercially available sensors (i.e., their Apple Watch, Google Fit, Jawbone, NikeFuel, or Misfit) to their HowNutsAreTheDutch diary data to study the interaction between their physical and psychological processes.
One study showed that positive affect and prosocial actions reinforce each other; Thus when an individual was feeling good in one six-hour period, they were more likely to do something prosocial in the next six hours, and vice versa, in line with the mood maintenance theory. Another study showed that negative affect predicted most differences in somatic symptoms between subjects, whereas positive affect predicted most variations in symptom levels within subjects. An increase in positive affect was followed by a decrease in somatic symptoms in the following 24 hours.
Psychopathology.
Psychological problems like major depression can be seen as complex dynamic systems in which symptom activation patterns can change suddenly (phase transitions). Researchers showed that people from the general Dutch population were not susceptible to these transitions whereas someone who had experienced a depression was, using mean field approximation.


Northeast Kingdom Human Services

The Northeast Kingdom Human Services (NKHS) is a US Government Contractor which is tasked with providing social services to people in the Northeast Kingdom, Vermont. These services include help with: chronic mental illness, developmental disabilities, substance abuse problems and other mental health and medical psychiatric needs.
It employed 480 workers in 2009. It had offices in Newport and St. Johnsbury.
In 2013, 200 employees moved to a facility in Derby.


William Erle Collins

William Erle "Bill" Collins (9 July 1929 – 28 September 2013) was an American parasitologist.
Collins grew up in Lansing, Michigan, where he graduated from high school. He received his B.S. and M.Sc. in entomology from Michigan State University and then completed his Ph.D. in 1954 at Rutgers University in two years. After being drafted into the U.S. Army, he did his military service at the U.S. Army Biological Warfare laboratories at Fort Detrick. While stationed there, he married Janet Johnson in July 1956. After leaving the Army he worked at Rutgers University as an extension entomologist. In 1959 he was employed by the U.S. Public Health Service at the National Institute of Allergy and Infectious Diseases (NIAID) in Columbia, South Carolina.
In 1973 the laboratory operation headed by Collins was transferred to the operational control of the Centers for Disease Control (CDC) and the research emphasis changed from monkey malarial parasites in monkeys to human malarial parasites in monkeys.
Collins was infected twice with "Plasmodium" during his years of laboratory work. He was the author or coauthor of more than 450 scientific publications.
Upon his death he was survived by his widow, two children, and two grandchildren.


Seboacanthoma

Seboacanthomas are a cutaneous condition, and a specific type of sebaceous adenoma which may be specific to Muir–Torre syndrome.


Alfonso Franco

Alfonso Franco (1466 – 1524), was an Italian painter from Messina, Sicily, active during the Italian Renaissance.
Biography.
He was a pupil of Jacobello da Antonello, son of Antonello Da Messina. He painted a "Deposition" for the church of San Francesco di Paola in Messina; and a "Dispute of Jesus at the Temple" for the church of Sant'Agostino. He died of the plague in 1524.


Disappearance of Ashley Summers

Ashley Nicole Summers (born June 16, 1993) was 14 years of age when she disappeared near her home in Cleveland, Ohio in early July 2007. , her whereabouts remain unknown, as there have been no verified sightings of Summers since her disappearance.
Disappearance.
Summers was last seen at around 6:00 p.m. on July 4, 2007. She was last seen in the area of West 96th Street and Madison Avenue. Earlier that day, Summers went to a pool party at which she was the only guest. After spending a few hours swimming in the pool, she decided to visit her aunt Christina, who lived within a 10-minute walking distance away from the pool, but never arrived. Because she was frequently staying with her relatives, her disappearance went unnoticed until two days later.
Her great-uncle Kevin Donathan said that he spoke with Summers on the morning of the day of her disappearance. Donathan grabbed Summers' phone and broke it, depriving Summers of her ability to contact her family or friends.
At the time of her disappearance, Summers had a tattoo of a heart and the word "Gene," in reference to Gene Gill, a boy whom she was dating at the time.
Investigation.
Summers was initially considered a runaway, due to her history with her family in the weeks leading up to her disappearance, including the rebellious act of getting a tattoo without her mother's permission. Even so, a week after Summers disappeared, her family banded together to search the neighborhood and surrounding areas for the girl. The FBI later speculated that she may have been kidnapped and that her disappearance might have been related to those of Amanda Berry and Gina DeJesus, who vanished in Cleveland in 2003 and 2004, respectively.
On May 6, 2013, Amanda Berry and Gina DeJesus were found alive and rescued from a house on Seymour Avenue. Police also found a third captive, Michelle Knight, who had been missing since 2002. Although Berry and DeJesus were well-known almost as soon as they disappeared, Knight received very little, if any, attention prior to their rescue and was absent from the FBI's missing persons database for most of the time she spent in the house. There was initially speculation that Summers may have also been a captive in that house, but no evidence of this was ever found.
On June 16, 2013, family and friends of Summers celebrated her twentieth birthday by passing out fliers and releasing balloons at West 110th and Lorain Avenue.
On November 7, 2018, police and the FBI visited Holmden Avenue, a location that Summers was known to visit. Authorities looked behind a home on Holmden Avenue, and uncovered new information on possible times and locations at which Summers might have been spotted before she disappeared.
Reported sightings.
In August 2007, one month after Summers went missing, her family received a phone call from a girl, believed to be Summers herself, telling them not to worry and that she was safe.
In early 2015, there were rumors that Summers had been spotted at an ATM in Rhode Island. The rumors were dismissed later that year, on July 6, 2015, two days after the eighth anniversary of her disappearance, when the FBI determined that the woman in the picture was not Summers.
Legal proceedings.
On December 4, 2018, Kevin Donathan was charged with rape, but has not been named a suspect in Summers' disappearance. On February 25, 2020, Donathan, 55, was sentenced to 35 years in prison on charges of rape and prostitution.
Cultural significance.
Summers was featured in a section of the show "Oprah" in October 2009, along with other missing people, including Sabrina Aisenberg and Jacob Wetterling, who disappeared in 1998 and 1989, respectively. Wetterling was found dead in 2016.


Thugs Get Lonely Too

"Thugs Get Lonely Too" is a song by rapper Tupac Shakur. The song was released as a promo single for his 2004 posthumous album "Loyal to the Game". The song was also used as the b-side to the album's lead single Ghetto Gospel. The song features singer Nate Dogg and was produced by Eminem. It charted at #55 on the Hot R&B/Hip-Hop Songs chart and at #98 on the "Billboard" Hot 100. As the song was released as a promotional single only, no official music video for the song was created. In 1993, Tech N9ne recorded a verse for the song, while living with QDIII, who at the time was putting in work on Strictly 4 My N.I.G.G.A.Z...
Original Version.
The original version of "Thugs Get Lonely Too" was recorded during the Strictly 4 My N.I.G.G.A.Z. & Thug Life era. It was produced by Stretch of the rap group Live Squad and sampled heavily from the song "If I Was Your Girlfriend" by Prince. The title of the song also resembles a track called Gigolos Get Lonely Too by The Time, composed by Prince.


Marcus Schrenker

Marcus Schrenker (born November 27, 1970) is a former American financial advisor. In 2009, he attempted to fake his own death due to personal, financial, and legal troubles. He was the subject of multi-state, three-day manhunt that followed.
His wife Michelle divorced him, and after pleading guilty to federal charges he was sentenced to 51 months in prison and fined $905,000 in June 2009. In October 2010, after pleading guilty to state charges, he was sentenced to 10 years in prison (consecutive with the 51 months) and was fined $633,781
Background.
Schrenker grew up in Merrillville, Indiana, and attended Purdue University, where he met his wife.
Prior to January 2009, Schrenker lived with his wife and three children in a $1M waterfront house in Geist, a wealthy suburb of Indianapolis. and he owned a plane and a Lexus.
Schrenker was listed as the owner of three companies, Heritage Wealth Management Inc. (HWM) and Icon Wealth Management, which had the same address, as well as Heritage Insurance Services, which was also at the same address. In December 2008 Schrenker and HWM were sued by another company that was trying to get back $1.4 million for commissions it had paid to Schrenker for selling insurance and annuity policies.
On December 30, 2008, his wife filed for divorce because he had been having an affair with a woman at the airport where he kept his plane. The next day, his Indiana state financial advisor license expired, all three of his companies were searched under a warrant related to ongoing investigations,
At the beginning of January, the Indiana Department of Insurance had filed a motion to revoke the license of Schrenker and Heritage and fine them, "citing a string of complaints from clients, some charging that he forged signatures and withdrew investment money causing large surrender penalties". On January 9, Schrenker had been ordered by a Maryland court to pay a Maryland insurance company $533,564 for issues also related to commissions. Schrenker was also being investigated by the FBI at the time the events occurred.
At least eight lawsuits had been filed against Schrenker in the ten years leading up to the events of January 2009, including slander, interfering with a business relationship, and failing to pay a contractor who worked on one of his homes.
Plane crash and manhunt.
On Saturday, January 10, 2009, Schrenker traveled to Harpersville, Alabama, in a pickup truck carrying a red Yamaha motorcycle with saddlebags containing money and supplies. He returned to Indiana after placing the motorcycle in a storage facility, telling the owner he would return and retrieve the motorcycle the following Monday.
On January 11, 2009, Schrenker departed in his turboprop single-engine Piper Meridian (tail number N428DC) from an airfield in Anderson, Indiana, scheduled to fly to Destin, Florida. Near Birmingham, Alabama, he made a distress call, telling air traffic controllers that his windshield had imploded and he was "bleeding profusely." He then set the plane to autopilot and parachuted out. Military jets that had been dispatched to intercept Schrenker's plane discovered it in flight, with its door open and cockpit empty. They followed the plane until it crashed just north of Milton, Florida at about 9:20pm. The plane had flown on autopilot and crashed 50 to 75 yards from a residential area. Upon inspecting the crash site, investigators discovered that there was no blood inside the plane and the windshield showed no sign of any problems. On board the aircraft they found a United States atlas and a national campground directory, both of which had the Florida and Alabama sections torn out.
After parachuting to the ground, Schrenker made his way to a private residence in Childersburg, Alabama, arriving around 2:30am on January 12. Appearing wet from the knees down, he told the resident he had been in a canoeing accident. He received a ride into town, where he made contact with the local police station. Not yet linking Schrenker to the crash, the police brought him to a hotel in Harpersville, where he checked in under a false name and paid for his room with cash. When police returned later that morning, he had fled on foot into nearby woods. Schrenker then traveled to the storage facility where he had earlier stored his motorcycle, and then rode the vehicle to a KOA Campground in Quincy, Florida. Without offering his name, he told the owners of the grounds that he was traveling cross country with friends, using cash to purchase a one-night tent site, firewood, and a six pack of Bud Light Lime. He was also given access to the campground's wireless internet.
On January 12, Schrenker emailed neighbor and friend Tom Britt, stating the crash was "a misunderstanding" and that he had checked into the motel because he was "embarrassed and scared" of returning home. He also said that he would likely "be gone" by the time Britt read the email. Britt turned the email over to the police. The same day, a Hamilton County Superior Court judge froze the assets of both Schrenker and his estranged wife.
Capture.
At about 10pm on January 13, officials captured Schrenker in a pup tent at the Quincy campground; they had roughly located him using information from the email he had sent. The ground's owners, Troy and Caroline Hastings, grew suspicious when the man had failed to check out by 5pm. Upon approaching Schrenker's site, Troy Hastings noticed a large red stain on the outer flap of his tent. The couple were soon contacted by the local sheriff, who asked if anything unusual had happened recently at the camp. Troy Hastings told the officer about the suspicious camper; shortly thereafter, authorities swarmed the campground.
Investigators told the press that he had slashed his left wrist, had an additional self-inflicted wound near his elbow, and was barely conscious. US Marshal Assistant Chief Deputy Frank Chiumento said that Schrenker "wasn’t able to speak very clearly. A lot of the words that he was speaking were unintelligible, but he mentioned 'die' at least two times as we were providing medical treatment to him." He was in a "very incoherent state" and had lost massive amounts of blood by the time authorities first arrived, but paramedics were able to control his bleeding and he was flown to Tallahassee Memorial Hospital. Among the items found at the campground with him were knives, a laptop computer, toiletries, clothes and maps.
Charges and trials.
On January 13, 2009, Schrenker was charged in Hamilton County, Indiana with 11 counts of unlawful acts by a compensated adviser and unlawful transaction by an investment adviser, and his bail was set at $4 million.
In May 2009 an Alabama judge granted a $12 million judgment against Schrenker related to the sale of an airplane to a man from Alabama.
In June 2009 Schrenker pleaded guilty to federal charges of destroying an aircraft and causing the U.S. Coast Guard to respond when no help was needed. In August he was sentenced to four years and three months in prison and was required to pay $34,000 in restitution to the Coast Guard and $871,000 in restitution to Harley-Davidson, the plane's lien-holder.
By August 2010, his possessions had been sold off and there were civil claims against him totaling about $20M. In August 2010 he reached a deal with Indiana prosecutors to plead guilty to five counts of securities fraud, serve 10 years in prison and pay victims of his schemes more than $630,000, and in October the judgement was entered, with the 10 years' imprisonment ordered to run consecutively with the sentence on the federal charges for the faked plane crash. A hearing on his ongoing divorce was scheduled for later that October.
On 25 September 2015, he was released on parole by the Florida Department of Correction with a scheduled termination date of 16 September 2019.


Jim Ferris

Jim Ferris is a professor for the Disabilities Studies Program at the University of Toledo in Toledo, Ohio. He is also the author of several books and journals on poetry and disability.
Biography.
Jim Ferris was born with what he describes as a "mobility impairment." His actual disability was that one leg grew shorter than the other. He was born in Cook County, Illinois, not far from Chicago where he later attended a school for crippled children. Ferris is cited as saying that he was a “defective child” who found himself in a “system intent on ‘fixing’ him.” This included surgery and rehabilitation meant to correct his disability.
Ferris has written several books, essays, and poems, including “Hospital Poems” and “The Enjambed Body.” Some of his work has received awards, including fellowship awards from the Wisconsin Arts Board.
He has taught at the University of Wisconsin-Madison and is currently the chair of the Disabilities Studies Program at the University of Toledo in Ohio. Ferris has said, “Poetry is an important part of what I do and how I think about experiences and respond to the world.”
Hospital Poems.
Winner of the 2004 MSR Poetry Book Award "Hospital Poems" was a collection of poems published
as a memoir to recall his childhood spent in the hospital. Many of these poems go deep inside Ferris's own journey. Ferris' poems range from humorous, to agitation, and optimism. His most well known poem, "Poet of Cripples", has gained critical acclaim for speaking out against the "fix-it" establishment.


Nodular hidradenoma


TEDMED

TEDMED is an annual conference focusing on health and medicine, with a year-round web-based community. TEDMED is an independent event operating under license from the nonprofit TED conference.
Background.
, TEDMED staff operates from Stamford, Connecticut.
Talks given at TEDMED combine “the nexus of health, information and technology” with “compelling personal stories” and “a glimpse into the future of healthcare.”
The intent of the conference has been described as “a gathering of geniuses” that brings together “some of the most innovative, thoughtful pioneers of healthcare technology, media, and entertainment into one big four-day ‘dinner party’ to learn from one another and mix people up from different disciplines and industries to solve big problems in healthcare.”
History.
TEDMED was founded in 1998 by TED’s founder Richard Wurman. TEDMED was inactive for a number of years, and in 2008 Wurman sold the rights to TEDMED to entrepreneur Marc Hodosh. Hodosh recreated TEDMED and launched its first conference under his guidance in San Diego in October 2009.
In January 2010, TED.com began including videos of TEDMED talks on the TED website. In October 2010, TEDMED was held in San Diego again and sold out for a second year, attracting notable healthcare leaders and Hollywood celebrities.
In 2011, Jay Walker and a group of executives and investors purchased TEDMED from Hodosh for $16 million with future additional payments of as much as $9 million. The conference was then moved to Washington, DC.
In November 2016, TEDMED was held in Palm Springs, California.


Primary small cell carcinoma of the skin