The major issues resulting from the globalization process back then were disease transmission, trading with rare foodstuffs, transferring of invasive and non-native species of animals and plants to other environments; in short, intervention in the natural environment of flora and fauna.
Najbolj pereč problem globalizacijskih procesov, ki so izhajali iz tedanjega trgovanja, so bili predvsem prenos bolezni, trgovanje z redkimi živili, prenos invazivnih, neavtohtonih vrst živali in rastlin v druga okolja, skratka poseganje v naravno okolje flore in favne.