disclosed are an artificial dura mater and manufacturing method thereof . the artificial dura mater includes electrospun layers prepared by electrostatic spinning , at least one of which is a hydrophobic electrospun layer . further , above the hydrophobic electrospun layer , there can be at least one hydrophilic electrospun layer . a transition layer can be further included between the hydrophobic and the hydrophilic electrospun layers . additionally , cytokines and / or medicines can be affixed to either or both of the hydrophobic and the hydrophilic electrospun layers , by way of bio - printing . the disclosed artificial dura mater shows good biocompatibility , enhances dural tissue regeneration , achieves excellent repairing effects , prevents adhesion , allows complete absorption , has good mechanical properties , ensures low infection rates , and can be loaded with therapeutic agents .