disclosed are compositions of matter treatment protocols and combination therapies aimed at stimulating neoangiogensis in ischemia tissue and means of acceleration host ischemic healing . in one embodiment antibiotics are administered to a patient in need of therapy , said antibiotics of endogenious microflora . subsequently probiotic and or probiotic and prebiotic are administered to generate “ natural ” microflora . said reconstituted microflora provides a means for generation of cardiac self - reactive t regulatory cells capable of stimulating angiogenesis and or myocardial protection .