the invention provides a method of using pregnadienones and pregnadienols represented by the structural formula as shown herein below wherein x ═ oh or o or combination thereof and positioning of olefinic bonds are at 4 ; 5 ; 6 ; 17 or various combinations and said compounds containing at least one olefinic bond in or on their d - ring for the treatment of hypolipidemic and hypoglycemic conditions in mammals , said method comprising administering an effective amount of the said compounds to the recipient mammals .