buccal aerosol sprays using polar and / or non - polar solvents have now been developed which provide propofol for rapid absorption through the oral mucosa , resulting in fast onset of effect . the buccal polar compositions of the invention comprise formulation i : propofol , a polar solvent and an optional flavoring agent ; formulation ii : propofol , a polar solvent , a propellant , and an optionally flavoring agent ; formulation iii : propofol , a non - polar solvent , and an optional flavoring agent ; formulation iv : propofol , a non - polar solvent , a propellant , and an optional flavoring agent ; formulation v : propofol , a mixture of a polar solvent and a non - polar solvent , and an optional flavoring agent ; and formulation vi : propofol , a mixture of a polar solvent and a non - polar solvent , a propellant , and an optional flavoring agent .