activation of pecam - 1 with , for example , a small molecule or antibody derivative provides a new therapeutic route for modifying platelet activation and thrombus formation which has utility in the treatment or prevention of cardiovascular diseases such as thrombosis , stroke , and vascular occlusion and in the treatment or prevention of homeostasis disorders . this treatment approach activates a general inhibitory mechanism . a screen for activators of pecam - 1 include pecam - 1 , an ectodomain of pecam - 1 , the cytoplasmic tail of pecam - 1 , the itim of pecam - 1 , an active site of pecam - 1 , a recombinant extracellular domain of pecam - 1 , or a part of derivative thereof and ways for detecting activation or cross - linking or phosphorylation or tyronsine phosphorylation of pecam - 1 , an ectodomain of pecam - 1 , the cytoplasmic tail of pecam - 1 , the ipim of pecam - 1 , an active site of pecam - 1 , a recombinant extracellular domain of pecam - 1 , or a part or derivative thereof .