the use of a ) an angiotensin - converting enzyme inhibitor such as captopril or enalapril , b ) an angiotensin ii - receptor antagonist such as saralasin or losartan , or c ) a renin inhibitor , such as remikiren or - phenylalanyl - histidyl - achpa - isoleucylamino ]- 2 - methyl - 2 - dihydroxy - 1 , 3 - propane , for the manufacture of a medicament for the treatment of uterine fibroids is disclosed . the ace inhibitor may be used concomitantly or sequentially with a gonadotropin - releasing hormone agonist such as buserelin or goserelin .