the present invention provides a series of artificial cpg - containing single - stranded oligodeoxynucleotides , each of which is consisted of single - stranded oligodeoxynucleotide dna molecule containing one or more cpg , wherein said odns can stimulate human peripheral blood mononuclear cell to produce antiviral substances . these odns can protect the cells against the attack from virus , wherein said virus is preferably selected from the group consisted of influenza virus and single - stranded positive strand rna virus such as sars virus , hepatitis c virus , dengue virus and japanese encephalitis virus . moreover , the antiviral use of artificial cpg odns and its use for treating and preventing viral infection are also provided .