the present invention relates to the use of piperphentonamine or pharmaceutically acceptable salts thereof to prevent / treat encephalopathy in mammals , and the use of a combination of piperphentonamine or pharmaceutically acceptable salts thereof and other medicines in manufacture a medicine to prevent / treat encephalopathy in mammals . the mammals include human beings , and the encephalopathy includes cerebral injury related diseases or cerebrovascular diseases . the cerebrovascular diseases refer to cerebral ischemia , cerebral ischemia / reperfusion - induced injury or cerebral hemorrhage . the cerebral hemorrhage includes hypertensive cerebral hemorrhage , cerebral hemorrhage secondary to infarction , tumor cerebral hemorrhage or cerebral hemorrhage caused by arteritis . the cerebral ischemia means carotid system cerebral ischemia or vertebrobasilar cerebral ischemia .