the present invention disclosed the pyrazolopyrimidinethione derivatives , salts and solvates thereof , preparation methods and use thereof . the pyrazolopyrimidinethione derivatives according to the present invention possess the structure of general formula i , wherein , r 1 , r 2 , r 3 , and r 4 represent alkyl , alkenyl , or aryl ; r 5 represents hydrogen , alkyl , alkenyl , alkoxy , cycloalkyloxy , aryl , or alkylacyl ; and r 6 represents hydrogen , alkyl , alkenyl , cycloalkyloxy , or alkylacyl . the pharmaceuticals containing the compound of the present invention and used for the treatment of impotence and sexlessness have the advantages of high selectivity over pde v , long action time , and less side reactions , and the pharmaceuticals will arouse no side reactions of blood pressure decreasing and heart rate increasing , and it has broad market propect .