the invention provides novel substituted pyridopyrimidines represented by formula i or a pharmaceutically acceptable salt , solvate , polymorph , ester , tautomer or prodrug thereof , and a composition comprising these compounds . the compounds provided can be used as inhibitors of the phosphoinositide 3 ′ oh kinase family for the treatment of inflammatory diseases , cancer , cardiovascular diseases , allergy , asthma and autoimmune disorders .