recombinant fc fusion proteins of human follicle - stimulating hormone with in vivo biological activities comparable to those of human follicle - stimulating hormone are disclosed . a recombinant hfsh - fc fusion protein comprises β subunit of hfsh , ctp , α subunit of hfsh , a flexible peptide linker , and human igg2 fe variant . a method is also disclosed to make such fusion proteins at good expression levels . these recombinant hfsh - fc fusion proteins of the present disclosure exhibit sufficient biological activities and prolonged plasma half - lives , leading to improved pharmacokinetics and pharmacodynamics . thus , a lower dosage may be used and / or better or different therapeutic efficacies with less side effects may be achieved . a method for the application of the recombinant hfsh - fc fusion proteins in the treatment and / or prevention of human infertility is also disclosed .