an immunomodulator which includes an antigen - presenting - cell targeting molecule coupled to an immunomodulatory antigen , wherein the apc - targeting molecule mimics a superantigen but does not include a fully functional t - cell receptor binding site . also disclosed are a method of therapeutic or prophylactic treatment of a disorder , including administrating to a subject in need thereof a pharmaceutical composition or a vaccine containing the immunomodulator ; use of the immunomodulator for the preparation of a medicament for the therapeutic or prophylactic treatment of a disorder ; and a method of preparing the immunomodulator .