this invention provides a pharmaceutical preparation or cosmetic , and a method for effectively inhibiting the abnormal accumulation of extra - cellular matrices . in addition , a method for preventing or treating a disease resulting from the abnormal accumulation of extra - cellular matrices is also disclosed . the pharmaceutical preparation or cosmetic contains as an effective ingredient at least one substance selected from the group consisting of the extract of a plant belonging to the genus artemisia , the genus forsythia , the genus sophorak the genus pheutn the genus gi rhiza , the genus arctium , the genus anemarrhena , the genus aralia , the genus anelicia , the genus akebia or the genus atractylodes , the genus akebia or the genus atractilodes , malotilate , 2 , 2 &# 39 ;- dipyridyl and o - phenanthroline .