the present invention discloses a method for preparing hbv vaccine comprising aluminum adjuvant , which belongs to biological technology field . the method , which is characterized in that aluminum adjuvant al 3 is produced by an on - line reaction , comprises mixing pbs buffer solution and potassium aluminum sulfate 2 ) solution with hepatitis b surface antigen stock solution , adding sodium hydroxide solution into the mixed solution , so that the adjuvant is continuously produced and hepatitis b surface antigens are continuously coated and absorbed simultaneously . the process is called “ in - situ adsorption ”.