this invention relates to a method for controlled administration of chemodernervating agents such as botulinum toxin - derived pharmaceutical , useful in attenuating neural stimulation and spasmotic activity of muscle . the method involves administration of novel dosage forms based upon the standardization of denervating pharmaceuticals . the invention also relates to novel methods of administering chemodernervating agents in a controlled and reproducible manner so as to confine their effects to a given region of muscle mass while minimizing paresis in adjacent muscle tissue .