an object of present invention is to provide a complete human anti - human tfr antibody , which specifically recognizes human tfr , inhibits the survival or growth of cancer cells that highly express tfr , and has no immunogenicity to humans . the present invention provides an antibody which specifically reacts with human tfr , wherein the antibody comprises any one of the amino acid sequences shown in seq id nos : 1 - 3 , 7 - 9 , 13 - 15 , 19 - 21 , 25 - 27 , 31 - 33 , 37 - 39 , 43 - 45 , 49 - 51 , 55 - 57 , 61 - 63 , 67 - 69 , 73 - 75 , 79 - 81 , 85 - 87 , 91 - 93 , 97 - 99 , 103 - 105 , 109 - 111 , and 115 - 117 , as each of a heavy chain first complementarity determining region , a heavy chain second complementarity determining region , and a heavy chain third complementarity determining region .