an optofluidic architecture for label free , highly parallel , detection of molecular interactions is based on the use of optically resonant devices whose resonant wavelength is shifted due to a local change in refractive index caused by a positive binding event between a surface bound molecule and its solution phase target . these devices have an extremely low limit of detection and are compatible with aqueous environments . the device combines the sensitivity of nanosensor technology with the parallelity of the microarray type format .