the present invention relates to the field of food or health care product , in particular a polysaccharide composition and use thereof . in the present invention , lentinan , pachymaran and tremellan are compounded . the resultant composition can significantly improve the survival rate and quality of life of mice infected by influenza virus , improve the pulmonary inflammatory lesion degree in mice infected by influenza virus , significantly improve levels of specific antibodies in serum of mice infected by influenza virus , significantly decrease the virus content in the lung of mice infected by influenza virus , as well as improve levels of cytokines il - 2 and il - 5 in the lung . in comparison with existing vaccines or single polysaccharides , the polysaccharide composition as provided in the present invention has more significant protective effects on mice infected by influenza virus .