most human tumors find ways to resist anticancer drug monotherapy . akt is considered a likely peptide providing such monotherapy drug resistance . data indicates that akt chemoresistance is induced in a p53 - dependent manner and that inhibition of akt may be an effective means of overcoming chemoresistance in cancer cells expressing wild - type p53 . breast , ovarian , lung cancer and leukemia cells lines were treated with combinations of akt activation inhibitor triciribine or triciribine phosphate and chemotherapeutic drugs to determine the efficiency of combination therapy . additionally , cells were introduced into xenograft models to determine in vivo effects of combination treatment . combining tcn or tcnp with other anticancer drugs overcame cytotoxic or treatment resistance . thus , tcn and tcnp are shown to broaden the spectrum of human tumors that can be effectively treated .