a syringe includes a cylindrical container in which is arranged at least a first piston which delimits a storage volume . the syringe is provided with at least one yielding element having a first side that delimits the storage volume in a liquid tight fashion , and having a second side that is in communication with the surroundings of the syringe . this renders the syringe liquid tight even if the pressure of the substance in the storage volume increases . this may be used when sterilizing with heat or when freeze drying substance in the syringe . the syringe can include a first piston with a first piston rod and a second piston with a second piston rod . the two pistons then define two storage volumes which may be used for storage of freeze dried substance and a solvent for the freeze dried substance , respectively . the different substances are unequally affected by heat sterilization , which may give rise to a pressure difference between the storage volumes , but the yielding element compensates for this such that no leaks between them occur .