novel methods of using thiazolidinone derivatives and related antihyperglycemic agents to treat populations at risk for developing noninsulin - dependent diabetes mellitus and complications arising therefrom are disclosed . in one embodiment , the compounds of the invention are used to treat polycystic ovary syndrome in order to prevent or delay the onset of noninsulin - dependent diabetes mellitus . in another embodiment , the compounds of the invention are used to treat gestational diabetes in order to prevent or delay the onset of noninsulin - dependent diabetes mellitus .