provided is a hyaluronic acid composition for use in treating or preventing mucosa related disorders or diseases including a mixture of has having different average molecular weights and different rheological , isolation , tissue scaffold and degradation properties . the resulting formulation demonstrates an optimal balance between adhesion , tissue scaffold and treating time on the treatment and prevention of mucosa related disorders or diseases including conjunctivitis , otitis , allergic rhinitis , gingivitis , oral ulcer , bronchitis , gastroesophageal reflux disease , esophagitis , gastritis , enteritis , peptic ulcer , inflammatory bowel disease , irritable bowel syndrome , urethritis , cystitis and vaginitis .