the present invention relates to new kinase inhibitors , more specifically rock inhibitors , compositions , in particular pharmaceuticals , comprising such inhibitors , and to uses of such inhibitors in the treatment and prophylaxis of disease . in particular , the present invention relates to new rock inhibitors , compositions , in particular pharmaceuticals , comprising such inhibitors , and to uses of such inhibitors in the treatment and prophylaxis of disease . in addition , the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction , inflammatory diseases , ophthalmic diseases and respiratory diseases .