the subject invention concerns the reduction of protein aggregation in the neurons of a mammal through the use of a ketogenic treatment such as a ketogenic diet , a physical training regimen and / or administration of agents to increase fatty acid oxidation . such ketogenic treatment can be useful in the reduction of certain aggregates including amyloid β peptide , polyglutamine containing huntintin protein , polyglutamine containing androgen receptor , polyglutamine containing atrophin - 1 , polyglutamine containing ataxins , α - synclein , prion protein , tau and superoxide dismutase 1 .