chiral 1 -- 5 - oxo -]- piperidin - 1 - yl }- pyrrolidine - 2 - carboxamides as inhibitors of collagen induced platelet activation and adhesion . the present invention provides chiral - 1 -- 5 - oxo --]- piperidin - 1 - yl }- pyrrolidine - 2 - carboxamide , and - 1 -- 5 - oxo --]- piperidin - 1 - yl }- pyrrolidine - 2 - carboxamide of formula 6 and 7 respectively . the present invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors . the present invention provides a process for preparation of chiral carboxamides of formula 6 and 7 using the process which has advantage to avoid any racemization at the a - carboxylic center , during n - alkylation . the reagent lihmds is used at low temperatures to furnish methyl n - 1pyroglutamate in good chiral purity .