septic shock is known to lead to , at the end stage , systematic inflammatory reaction syndrome and multiple organ failure and cause the patients &# 39 ; death . in both diseases , the patient dies finally of mof , and the infiltration by inflammatory cells plays a key role for mof . thus , development of therapeutic agents for septic shock by suppressing the infiltration by inflammatory cells has been desired . to provide a therapeutic or preventive agent for shock , comprising as an active ingredient a diaminotrifluoromethylpyridine derivative represented by the formula or its salt : wherein x is a cycloalkylcarbonyl group , an alkenylcarbonyl group , a thiophenecarbonyl group or a benzoyl group which may be substituted by a halogen atom ; and y is an alkylsulfonyl group .