other features of the invention will become apparent in the course of the following description of exemplary embodiment , which is given for illustration of the invention , and are not intended to be limiting thereof . dicyclohexylamine ( 17 . 2 g ) in n , n - dimethylacetamide ( 50 ml ) was added to a solution of cefuroxime acid ( 42 . 4 g ) in n , n - dimethylacetamide ( 300 ml ) at about − 10 ° c . ( r , s ) 1 - acetoxethylbromide ( 33 . 4 g ) in n , n - dimethylacetamide ( 50 ml ) was added to the above solution and the reaction mixture was stirred for 45 minutes at about − 3 to 0 ° c . potassium carbonate ( 1 . 1 g ) was added to the reaction mixture and it was further stirred at that temperature for about 4 hours . the reaction mixture was worked up by pouring into it ethyl acetate ( 1 . 0 it ), water ( 1 . 2 it ) and dilute hydrochloric acid ( 3 . 5 % w / w , 200 ml ). the organic layer was separated and the aqueous layer was again extracted with ethyl acetate . the combined organic extracts were washed with water , dilute sodium bicarbonate solution ( 1 %), sodium chloride solution and evaporated in vacuo to give a residue . methanol was added to the residue and the crude product was precipitated by adding water . the resulting precipitate was filtered off and recrystallized from the mixture of ethylacetate , methanol and hexane . the precipitated product was filtered , washed and dried to give pure crystalline cefuroxime axetil ( 42 . 5 g ). assay ( by hplc on anhydrous basis )- 98 . 2 % w / w ; diastereoisomer ratio - 0 . 53 ; total related substances - 0 . 48 % w / w . dicyclohexylamine ( 17 . 2 g ) in n , n - dimethylacetamide ( 50 ml ) was added to a solution of cefuroxime acid ( 42 . 4 g ) in n , n - dimethylacetamide ( 300 ml ) at about − 10 ° c . ( r , s )- 1 - acetoxethylbromide ( 33 . 4 g ) in n , n - dimethylacetamide ( 50 ml ) was added to the above solution and the reaction mixture was stirred for 90 minutes at about − 3 to 0 ° c . potassium carbonate ( 1 . 2 g ) was added to the reaction mixture and it was further stirred at that temperature for about 4 hours . the reaction mixture was worked up by pouring into it ethyl acetate ( 1 . 0 it ), water ( 1 . 2 it ) and dilute hydrochloric acid ( 3 . 5 % w / w , 200 ml ). the organic layer was separated and the aqueous layer was again extracted with ethyl acetate . the combined organic extracts were washed with water , dilute sodium bicarbonate solution ( 1 %), sodium chloride solution and evaporated in vacuo to give a residue . methanol was added to the residue and the product was precipitated by adding cyclohexane . the precipitated product was filtered , washed and dried to give pure crystalline cefuroxime axetil ( 44 . 5 g ). assay ( by hplc on anhydrous basis )- 99 . 1 % w / w ; diastereoisomer ratio - 0 . 53 ; total related substances - 0 . 6 % w / w . while the present invention has been described in terms of its specific embodiments , certain modifications and equivalents will be apparent to those skilled in the art and are intended to be included within the scope of the present invention .