the compound of this invention may be obtained , for example , by preparing basic 13 - propylberberine and then adding an equimolar amount of sulfuric acid or phosphoric acid thereto , both , in a manner known per se in the art . more specifically , basic 13 - propylberberine may be prepared usually by causing a propyl halide to act on acetone berberine or by causing an allyl halide to act on acetone berberine and then reducing the allyl group . the sulfuric or phosphoric acid addition salt of 13 - propylberberine may be prepared by adding a solution of an equimolar amount or more of sulfuric acid or phosphoric acid in a suitable solvent such as methylene chloride , methanol or ethanol to basic 13 - propylberberine and after optionally heating the resultant mixture to dissolve the basic 13 - propylberberine if needed , adding a bad solvent such as ethyl ether or chloroform suitably to the solution and collecting precipitated crystals or distilling off the solvent to convert the resultant salt into crystals . the antidiarrheic effect of the compound of this invention was tested in accordance with the following method . results are shown in table 1 . an experiment was conducted by the method proposed by m . sabir et al [ ind . j . med . res . 65 , 303 ( 1977 )]. namely , spf male wister rats of 6 - 7 weeks old , three rats per group , were fasted for 72 hours . under sodium pentobarbital anesthesia , they were each subjected to laparotomy , followed by ligation at the beginning of the jejunum and at the end of the ileum . one of the test compounds and 20 μg of cholera toxin were injected in the ligated tract and 5 hours later , the amount of secreta was measured . besides , a control injected only with cholera toxin was also provided to calculate inhibition rates (%). table 1______________________________________ injected inhibitiontest compound amount ( mg / kg ) rate (%) ______________________________________berberine chloride 20 8 . 013 - propylberberine 2 40 . 0bisulfate13 - propylberberine 0 . 5 13 . 0bisulfate______________________________________ as shown in the above table , the compound of this invention has an extremely - stronger inhibitory effect against secretion compared with berberine chloride which has conventionally been known to control diarrhea . test compounds were heated at 100 ° c . for 8 hours . changes in their appearance and their percent remainders were studied . results are shown in table 2 . table 2______________________________________ changes in percenttest compound appearance remainder (%) ______________________________________13 - propylberberine no changes 100 . 0bisulfate13 - propylberberine no changes 99 . 8primary phosphate13 - propylberberine turned 48 . 7chloride to brown13 - propylberberine turned 57 . 0bromide to brown13 - propylberberine turned 52 . 1iodide to brown______________________________________ as shown in the above table , the bisulfate and primary phosphate of this invention are extremely stable compared with the conventionally - known halides . table 3______________________________________test compound solubility______________________________________13 - propylberberine bisulfate soluble13 - propylberberine primary phosphate soluble13 - propylberberine chloride slightly soluble13 - propylberberine bromide slightly soluble13 - propylberberine iodide slightly soluble______________________________________ as readily envisaged from the above table , the compounds of this invention have such advantages that compared with the conventionally - known halides , both of them have high water solubilities and their effects are shown promptly after their oral administration . the manner of administration and dosage of the compounds of this invention will next be described . regarding the manner of their administration , it is preferable to administer them orally in such preparation forms as tablets , capsules , granules , syrup and the like . their oral preparations such as their tablets , capsules , granules and the like may be produced by formulating them suitably in combination with a excipient such as starch , lactose or mannitol , a binder such as sodium carboxymethylcellulose or hydroxypropyl cellulose , a disintegrator such as crystalline cellulose or calcium carboxymethylcellulose , a lubricant such as talc or magnesium stearate , a fluidity improver such as light silicic anhydride and the like . as to their dosage , it is ordinarily suitable to administer 0 . 01 - 10 mg / kg . administration 2 - 3 times a day in the case of an adult . the compounds of this invention can also be used advantageously as biochemical reagents and the like owing to their strong inhibitory effects against the activity of adenylate cyclase . the present invention will next be described by the following examples and referential examples . five grams of acetone berberine were provided , followed by an addition of 50 ml of chloroform to dissolve the acetone berberine . then , 10 ml of allyl bromide was added . after fitting a reflux condenser , the resultant mixture was refluxed for 7 hours . after distilling any excess allyl bromide off together with the solvent , to the residue 50 ml of methylene chloride was added and the precipitated yellow crystals were filtered off . the filtrate was concentrated , followed by an addition of a small amount of ethyl ether . subsequent to collection of the precipitated yellow crystals by filtration , the crystals were washed with a small amount of a mixed solution of chloroform and ethyl ether and were then dried to obtain 2 . 81 g of 13 - allylberberine bromide . thereafter , 1 . 5 g of the above - prepared 13 - allylberberine was dissolved in 40 ml of ethanol , followed by an addition of 1 . 5 g of 10 % pd - c . the 13 - allylberberine was then catalytically reduced by passing hydrogen gas through the liquid mixture . after completion of the reaction , the catalyst was filtered off and the filtrate was concentrated . the precipitated yellow crystals were then collected by filtration . thereafter , they were washed with a mixed solvent of chloroform and ethyl ether and dried to obtain 1 . 4 g of 13 - propylberberine bromide . after adding 5 ml of methylene chloride and 1 ml of methanol to 0 . 3 g of 13 - propylberberine and dissolving the latter , 2 ml of a 5 % sulfuric acid solution in methanol was added . after adding ethyl ether until right before precipitation of crystals , the resultant solution was allowed to stand overnight . the precipitated yellow crystals were collected by filtration . the crystals were then washed with a small amount of a mixed solution of chloroform and ethyl ether , followed by their drying under reduced pressure to obtain 0 . 14 g of 13 - propylberberine bisulfate . elementary analysis (%): calculated for c 23 h 25 no 8 s ( 475 . 51 ): c , 58 . 10 ; h , 5 . 30 ; n , 2 . 95 . found : c , 57 . 86 ; h , 5 . 52 ; n , 2 . 97 . after adding 5 ml of methylene chloride and 1 ml of methanol to 0 . 3 g of 13 - propylberberine and dissolving the latter , 2 ml of a 5 % phosphoric acid solution in methanol was added . after adding ethyl ether until right before precipitation of crystals , the resultant solution was allowed to stand overnight . the precipitated yellow crystals were collected by filtration . the crystals were then washed with a small amount of a mixed solution of chloroform and ethyl ether , followed by their drying under reduced pressure to obtain 0 . 13 g of 13 - propylberberine primary phosphate . elementary analysis (%): calculated for c 23 h 26 no 8 p ( 475 . 43 ): c , 58 . 11 ; h , 5 . 51 ; n , 2 . 95 . found : c , 58 . 02 ; h , 5 . 66 ; n , 2 . 91 . ______________________________________13 - propylberberine bisulfate 50 mgd - mannitol 200 mgcrystalline cellulose 50 mgpotato starch 28 mgcalcium carboxymethylcellulose 16 mgtalc 4 mgmagnesium stearate 2 mgtotal 350 mg______________________________________ the above components in the above amounts were mixed , from which a single piece of tablet was prepared in a usual manner . ______________________________________13 - propylberberine primary phosphate 25 mgcrystalline cellulose 17 mglight silicic anhydride 7 mgmagnesium stearate 1 mglactose 130 mgtotal 180 mg______________________________________ the above components in the above amounts were mixed , from which granules were prepared in a usual manner . they were then filled in a single piece of no . 3 capsule to obtain a capsule . at 200 nm concentration , 13 - propylberberin bisulfate inhibits about 50 % of adenylate cyclase activity of intestinal epithetial cells or splenic lymphocytes in mice . having now fully described the invention , it will be apparent to one of ordinary skill in the art that many changes and modifications can be made thereto without departing from the spirit or scope of the present invention as set forth herein .