in preparing angiogenesis radiolabelled products , an important building block in the synthesis of obtaining a radiolabelled peptide based compound is identifying a reliable and efficient linker . in the present invention , even though there is no commercial available reagent for the peg - linker , a convenient synthesis from commercial cost - effective reagents are disclosed herein . specifically , the present invention claims novel intermediate synthesis for quickly and efficiently obtaining a peg linker . there are advantages for using the claimed synthesis to obtain a peg linker . one advantage is that the claimed synthesis is a quick process for obtaining a peg - linker . more specifically , using linker k1 , disclosed herein , for large scale production is advantageous from a cost perspective point when using intermediates such as compound f1 and h1 . there are several advantages for synthesizing modified polyethylene glycols to obtain the claimed peg linker . one advantage is that the claimed synthesis is a shorter and faster process for obtaining a peg linker . the convenient synthesis used herein can be carried out in half - a - day thus making it possible to produce a peg moiety in under one week . unless otherwise defined herein below all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention pertains . a peg ( polyethylene glycol ) is a chain of individual ethylene glycols . the term linker as used herein means a moiety that links together at least two other moieties , such as a vector and a reporter . the use of linker groups with different lipophilicities and or charge can significantly change the in vivo pharmacokinetics of a peptide to suit the diagnostic need . a wide variety of linkers may be used , including biodegradable linkers and biopolymers . the linker is at its simplest a bond between the vector and the aminoxy group . more generally , the linker will provide a mono - or multi - molecular skeleton , e . g . a linear , cyclic , or branched skeleton . the linker may further have the role to distance the vector from the reporter . the linker described herein specifically comprises macromolecular structures such as dextran and preferably poly ( ethyleneglycols ), referred to as pegs . linkers including a peg moiety have been found to slow blood clearance which is desirable in some circumstances . the linker may be derived from glutaric and / or succinic acid and / or a polyethyleneglycol based moiety . all molecules that have a peg center moiety of different lengths and a protected aminoxy acetic acid on one side and a spacer connected as an amide to other terminal end of the peg moiety can be synthesized following the described synthetic protocol accordingly in preparing formula ( 1 ) without the use of an azide , the anion with the formula n 3 − . additionally , the synthetic protocol described below enables formation of peg moieties of different lengths , i . e . the number of ethylene glycols coupled in series . a vector is defined herein as a fragment of a compound or moiety having affinity for a receptor molecule , preferably a peptidic species or more preferably an angiogenesis targeting species such as an rgd peptide . a specific example of a vector used herein is an arg - gly - asp peptide or an analogue thereof . in the synthesis described herein the boxed in part disclosed in the claimed reaction below can be preformed in a one - pot procedure . one embodiment of the present invention depicts a method for preparing a linker of formula ( k1 ), comprising the following reactions : where r2 = alkyl or aryl and more preferably r2 = h where pg is formyl or r2 is a methyl wherein pg is acetyl and most preferably where r2 = phenyl where pg is benzoyl or further wherein pg can be alkyl or aryl and more preferable allyl or most preferable benzyl and n denotes 1 - 19 . another embodiment of the present invention depicts a method for preparing compounds e1 and l1 from above wherein the h1 and g1 is separated from l1 by extraction or crystallization . yet another embodiment of the present invention depicts a method from the above synthesis wherein c1 reacts with e1 to form a mixture of f1 , g1 , and e1 wherein e1 is made from a polypropylene glycol by introduction of a leaving group ( lg ) on both terminal hydroxyl groups . still a further embodiment of the present invention shows a method according to the above reaction , wherein the preferred temperature is about 22 ° c . and the preferred time is about 5 - 8 hours . another embodiment of the present invention shows a method according to the above synthesis , wherein the mixture of f1 , g1 , and e1 reacts with a phthalimide salt to form a mixture of h1 , g1 , and l1 . still another embodiment of the present invention depicts a method according to the above synthesis , wherein the mixture of f1 , g1 , and e1 reacts with a phthalimide salt to form a mixture of h1 , g1 , and l1 at a temperature range from about 30 ° c . to about 70 ° c . and for about an hour to about four hours . yet another embodiment of the present invention shows a method according to the above synthesis , wherein h1 is isolated from g1 by chromatography or crystallization . the invention is further described in the following examples , which are in no way intended to limit the scope of the invention . the invention is illustrated by way of examples in which the following abbreviations are used : m + h + : defined herein as mass of an ion detected in mass spectrometry as the adduct between a molecule and a proton . m + na + : defined herein as mass of an ion detected in mass spectrometry as the adduct between a molecule and a sodium ion . a synthetic route for the synthesis of a boc - protected aminoxy linker is seen in fig1 below . ms and ls - ms were the major analytical tools used for identification of the intermediates . all synthetic steps were carried out using relatively inexpensive and readily available starting materials and chemicals . none of the steps can be identified as costly or inefficient . experimental data of each process step for the synthesis of the boc - protected aminoxy linker n - acylations with anhydrides are common and convenient synthetic tools for formation of amides from amines . a pre - made solution of p - toluene sulfonylchloride was added dropwise over 60 min to a solution of triethylamine and 1 , 11 - dihydroxy - 3 , 6 , 9 - trioxa - undecane ( teg ) ( 2 ) chloroform . the reaction mixture was stirred at ambient temperature ( 20 - 23 ° c .) over night . the reaction mixture was thereafter filtered and the filtrate evaporated under reduced pressure . residue was first mixed and shaken with hexane , thereafter with ethyl acetate / hexane 1 : 1 and finally the product was extracted from the residue by suspending the residue in ethyl acetate . the suspension was filtered and the product collected in the filtrate . the filtrate was evaporated under reduced pressure and the residue analysed by ms . the ms confirmed a mix of unreacted , monotosvlated ( m + h + 349 . 14 ) and ditosvlated ( m + h + 503 . 15 ) the tosylated teg ( 3 ) from first step was dissolved in dmf and potassium phthalimide and added . the reaction mixture was stirred at 80 ° c . over night . the morning after the temperature was raised to 90 ° c . for two hours . after cooling to room temperature the mixture was filtered and the filtrate evaporated under reduced pressure . the residue was mixed with methanol and filtered and the filtrate evaporated under reduced pressure . this procedure was repeated with diethyl ether . the crude n -( 3 , 6 , 9 - trioxa - 11 - hydroxy - undecane )- phthalimide containing bis - n - phthalimide was dissolved in as little thf as possible . the thf solution was added drop wise to water at 40 - 60 ° c . the bisamide precipitated from water and was removed by filtration after cooling . the filtrate was evaporated under reduced pressure and the diethyl ether was added to the residue and product extracted from the solid residue into the diethyl ether . the ether was decanted and the procedure repeated once . the residue was mixed with water and extracted with 1 × diethyl ether and 2 × ethyl acetate . the combined ethyl acetate phases were evaporated under reduced pressure . the ether phases were combined , decanted and evaporated . the residue was dissolved in ethyl acetate and the solution was added to the product isolated from exhilarate extraction . this second ethyl acetate solution was evaporated under reduced pressure . the structure of 4 was confirmed by 1 h - nmr . 100 mg of compound 4 was dissolved in methanol and hydrazine monohydrate added . the mixture was heated to 50 ° c . for 3 hours , cooled to room temperature and stirred at room temperature over night . the amine 5 was mixed with dichloromethane and some dmf as co - solvent . 1 . 5 mole eqv . diglycolic anhydride wad added and the mixture heated to 40 ° c . for a couple of hours . after cooling to room temperature and stirring over weekend the reaction mixture was evaporated under reduced pressure . the residue was mixed with water and ph adjusted to ph between 11 - 12 with 1n naoh ( aq ) for hydrolysis of the ester . the solution was allowed to stir over night and was thereafter acidified with hcl to ph 1 - 2 and evaporated under reduced pressure . lc - ms of the residue showed a major peak with the expected masses m + h + 310 . 15 and m + na + 332 . 13 . ( boc - aminooxy ) acetic acid ( 7 ) was dissolved in acetic anhydride and heated to 50 - 60 ° c . over the weekend . lc - ms of the reaction mixture showed several different products including the mixed anhydride 7a and the symmetric anhydride 8 . the anhydride 7a was originally the target compound , however , 8 was found in the reaction mixture and is a better reagent than 7a for the next step ( see above ) since n - acylation with 7a can give two different products ; n -( boc - aminooxy ) acetamide as the wanted product and n - acetamide as by - product . structure of compound 8 was confirmed by lc - ms ( m + h + 365 ) fragments with m + h + 265 . 1 and m + h + 165 indicated the loss of one and two boc - groups . a mixture containing compound 8 was dissolved in thf and 2 ( 2 - aminoethyl ) ethanol added . the reaction mixture was stirred at room temperature for 3 days . the reaction mixture was mixed with water and ph adjusted to above 10 with naoh ( aq ) and stirred over night . the reaction mixture was added to thf and brine and extracted . the evaporated thf phase was used directly in the next step . the target compound a boc - protected aminoxy linker is to be made by coupling between intermediate 6 and 10 . results for the experiments shows that both compound 6 ( 4 synthetic steps ) and 10 ( 3 synthetic steps ) can be made by simple synthetic methods . compound 10 was made in three synthetic steps without any form for purification . the ether formation using the suggested method was confirmed in experiment ix above . an important step in the synthesis is formation of compound 9 . there are several approaches to perform this . one is to make the acid halide of compound 7 , however , the boc group is not to stable during e . g . acid chlorination . one other method is to use coupling reagents . a problem using couplings reagents is the low molecular weights of product and reagents . the formation of compound 8 might be the better solution and the formation is proved in experiment vi , see above . tuning of this synthesis to give a relatively pure compound 8 seems to be the key for success . a follow - up on this step is done by using an in - situ made mixed anhydride between formic - and acetic acid . the higher reactivity of formyl over acetyl would give a mixed anhydride between 7 and formyl . the formyl group is less stable than acetyl and the formation of 8 should be favored if 7 is present . the anhydride 8 is regarded as the thermodynamic preferred structure over the mixed anhydrides . the present invention is not to be limited in scope by specific embodiments described herein . indeed , various modifications of the inventions in addition to those described herein will become apparent to those skilled in the art from the foregoing description and accompanying figures . such modifications are intended to fall within the scope of the appended claims . various publications and patent applications are cited herein , the disclosures of which are incorporated by reference in their entireties .