for the purpose of preparing the immunoglobulin of yolk against dental caries bacteria and the combination , streptococcus mutans type c and type d are used as antigen bacteria , the antibody is purified by water dilution , deae - sephadex a50 and sephadex g200 chromatography . it is low cost of production , high titer , strong resistance to osmotic pressure , and high immune activity and wide range of cross - reaction to streptococcus mutans . present invention provides the combination preventing dental caries wherein the effective components are igy and antiseptic features in safe use and effective prevention ; the combination is effectively preventing dental caries .