the present invention relates to a method of treating cellular proliferative diseases , in particular cancer , which comprises administering a modulator of the activity of the mitotic kinesin ksp , wherein the activity of the ksp modulator is dependent on the presence of microtubules . it is believed that the ksp modulators utilized in the instant method bind to the ksp protein in a previously unreported manner , since the compounds do not bind competitively with respect to either microtubules or atp , the substrates of ksp . the modulators useful in the instant methods are furthermore not active against the non - microtubule stimulated activity of ksp . cellular proliferative diseases that may be treated using the method disclosed herein are , for example cancer , hyperplasias , restenosis , cardiac hypertrophy , immune disorders and inflammation .