a peptide nanotube device and method of manufacturing thereof are disclosed herein . the pnt device comprises pnts composed of cyclo - peptide and a matrix , including biomolecules , complexed with the pnts . the pnt device is biodegradable and biocompatible , as well as capable of being uptake by mammalian cells . wherein , the biomolecules comprise peptides , proteins , nucleic acids including dna , shrna and sirna , and drugs . the method for manufacturing pnt device comprises : dissolving a cyclo - peptide powder in a solvent to be a solution in a container ; incubating the solution at a predetermined temperature for a predetermined time for the solvent to evaporate to obtain pnts formed of cyclo - peptide ; and mixing the pnts with a matrix including biomolecules to obtain the pnt device .