in accordance with the present invention , novel methods and formulations are provided for treating and preventing the incidence of drug - induced pro - arrhythmia , including torsades de pointes . the methods and formulations comprise a combination of a drug that induces torsade de pointes , such as class iii antiarrhythmics , certain antimicrobials , antihistamines , antidepressants , antipsychotics , diuretics , with an aspirin and / or a statin . in certain embodiments , the compositions and methods for treatment comprise azimilide and aspirin and / or a statin . these compositions may be administered by different routes , including orally . in certain embodiments where the antiarrhythmic is azimilide it may be administered orally in a dose of about 25 mg to about 300 mg .