this invention is directed to therapeutic compositions containing non - mhc - restricted t - cells / nk - cells in combination with mhc - restricted t - cells and especially to therapeutic compositions , which comprise lak cells . furthermore , the present invention is directed to the use of the above combination in the treatment of tumors in humans , which tumors show a missing , low or aberrant expression of mhc class 1a or 1b molecules . by using the aforementioned compositions / combinations it is possible to provide a balanced selective pressure against emergence of tumor cell variants that would otherwise escape immune detection .