novel polymer - associated liposomes containing a liposome , and a polymer having a plurality of acid moieties , like sulfonic acid moieties , carboxyl moieties , or phosphonic acid moieties , in a salt form are disclosed . drug compositions containing a pal and a drug are administered to individuals suffering from a disease , and the drug is released , in vivo , to treat the disease , and to reduce , eliminate , or reverse complications associated with the disease .