a controlled - release oral pharmaceutical composition of at least an active agent , including : a ) a lipophilic matrix consisting of lipophilic compounds and / or amphiphilic compounds ; and b ) an hydrophilic matrix , wherein the hydrophilic matrix includes at least an indigestible polysaccharide , the active ingredient being dispersed in the lipophilic and / or the hydrophilic matrix . the present invention also relates to a process for the preparation of such a pharmaceutical composition .