compounds possessing hypoglycemic , hypotensive , antiinflammatory , anticoagulant and diuretic activity are represented by compounds of the following formula ## str1 ## wherein y is thienyl , cycloalkyl of from 5 to 7 carbon atoms , phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen , such as fluorine , chlorine , bromine or iodine , lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms ; z is hydrogen or hydroxy ; r is hydrogen , lower alkyl of from 1 to 4 carbon atoms , phenyl or benzyl ; r 1 is hydrogen , lower alkyl of from 1 to 4 carbon atoms or halogen , such as chlorine , fluorine , bromine or iodine ; m is from 3 to 6 ; and n is from 3 to 11 . pharmaceutical compositions of these compounds and their use are also disclosed .