the present invention discloses a dissoluble pdms - modified p amphiphilic copolymer and the method of fabricating the same . the amphiphilic copolymer of the present invention is fabricated via chemically bonding hema , maa , and poly , bis terminated in aqueous solution . the pdms - modified p amphiphilic copolymer can be dissolved completely in polar solvents , particularly alcohol solvents , to facilitate subsequent processing . the amphiphilic copolymer features adjustable hydrophobic - hydrophilic properties and exhibits excellent biocompatibility . thus , it can be utilized in a number of advanced applications , including anti - fouling and drug delivery .