a use of recombinant ganoderma immunoregulatory protein in a preparation of a drug for treating melanoma is disclosed . by establishing experimental animal models of orthotopic tumors and metastatic tumors , an anti - tumor effect of the rlz - 8 is researched , which indicates that the rlz - 8 significantly inhibits a growth of the orthotopic tumors of the melanoma and a formation of metastases of the melanoma .