the invention concerns a method for obtaining and selecting monoclonal antibodies by an addc - type test , said antibodies capable of activating type iii fcy receptors and having a particular glycan structure . the inventive anti - d antibodies can be used for preventing rhesus isoimmunisation in rh negative persons , in particular for haemolytic disease in a new - born baby of for uses such as idiopathic thrombocytopenic pupura 9itp ).