the invention provides methodologies and apparatus for producing devitalized soft - tissue implants where the implant retains metabolically non - viable and / or reproductively non - viable cells , and preferably retains large molecular weight cytoplasmic proteins , such implants produced both in small quantities and in commercializable quantities . such soft - tissue implants include vascular graft substitutes . a devitalized graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution , optionally followed by inducing a pressure mediated flow of a salt solution , then washing the tissue to produce the devitalized graft . the devitalized grafts produced are uniform and non - immunogenic . the inventive method allows for the production of multiple devitalized soft tissue implants , where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes . in clinical use , the devitalized grafts produced exhibit significantly improved in long - term durability and function , and enhanced recellularization post - implantation .