the present invention concerns novel amidines derivatives of 2 - heteroaryl - quinazoline and quinolines of general formula , to a process for their preparation , to their pharmaceutical compositions and to the use of these compounds , salts and solvates thereof , along with the corresponding pharmaceutical compositions , for the treatment of pain and inflammatory disorders . compounds of this invention are extremely potent analgesics , suitable for the treatment of both inflammatory and neuropathic pain . particularly for the treatment of neuropathic pain the compounds of the invention have been proved largely superior to the standards currently in the clinical use . these compounds are not acting through inhibition of cox or nos enzymes but are effective in inhibiting inflammatory cytokine production induced by inflammatory stimuli .