the invention provides a fully human anti - her2 monoclonal antibody , which has an amino acid sequence of heavy chain variable region as shown in seq id no : 6 and an amino acid sequence of light chain variable region as shown in seq id no : 8 . the invention also discloses the nucleotide sequence encoding the antibody , the expression vector and the host cell comprising the nucleotide sequence , and the use of the antibody for manufacturing the medicament for the treatment of tumor .