this invention is directed to tissue equivalent prostheses containing perforations , which when grafted to a mammalian host , serves as a replacement body part or tissue structure while integrating with the tissue of host . the perforations provide channels for cellular ingrowth thus improving integration of the tissue equivalent to the host tissue . the prostheses of this invention , in their various embodiments , thus have dual properties : first , they function as a substitute body part , and second , they function as a template for cellular ingrowth and bioremodeling by the host cells .