the present invention is directed towards a method of modulation of the innate immune of an organism system with the phosphorylated polyprenols of the present invention . the present invention is also directed towards a method of activation and / or modulation of the toll - like receptors with the phosphorylated polyprenols of the present invention . the present invention is also directed towards compound comprising c35 - c90 polyisoprenyls of formula 1 and formula 2 and their derivatives as well as methods of use of including activation and / or modulation of tlrs including tlr - 2 and tlr - 4 receptors and uses thereof including , e . g ., use as antimicrobial , immunoregulatory , anti - cancer , cancer , for control of inflammatory conditions and as vaccine adjuvants .