the invention herein relates to a pharmaceutical composition containing loratadine and derivatives thereof which is suitable for use in soft capsule dosage forms . a pharmaceutical composition according to the invention comprises loratadine and derivatives thereof in a pharmaceutically effective amount ; and a solvent system comprising a mixture of medium chain fatty acids . the loratadine compositions exhibit good solubility and storage stability while maintaining bioavailability of the drug . the compositions also permit high concentrations of solubilized loratadine per total fill volume and thereby permit the use of smaller capsules to deliver the same dosage of drug .