the present invention relates to the biological and pharmacological effects of placental protein 13 , an effect that may be used as a treatment and / or prevention of preeclampsia and placental insufficiencies , in pregnant female mammals , especially pregnant women . the invention relates to a method to treat female mammals with the purpose to precondition the uterine arteries and prevent and / or reverse the pathological conditions associated with placental insufficiency such as preeclampsia , hellp and / or eclampsia .