the method of secure communication between the endpoints is used for the secret communication between endpoints locating in different gatekeeper management area , and the method includes : in the process of the caller endpoint calling the callee endpoint , the home gatekeeper of the callee endpoint generates the share secret key between the caller endpoint and the callee endpoint ; the secure communication process is performed between the caller endpoint and the callee endpoint according to the share secret key . according to the secure communication method between the endpoints , the invention makes that secret communication mechanism between the endpoints locating the different gatekeeper management area has better expansibility and higher efficiency .