a topical preparation of danazol comprising a matrix base , danazol retained therein , and optionally a release - promoting agent is provided . the topical preparation is more effective than oral administration of danazol in the shrinkage of endometriosis tissue , the induction of pregnancy , and the like . it does not show any side effects that have been encountered in the oral administration of danazol . thus , the preparation is very useful remedy for endometriosis .