the present invention provides devices and methods for use in the perfusion of organs and anatomical regions . in one aspect the present method provides a percutaneously deliverable device for supporting a vessel in a human or animal subject including means for supporting the vessel during delivery of a fluid thereto or collection of a fluid therefrom . in another aspect the invention provides a method for delivery or collection of a fluid to or from an organ or anatomical region in a human or animal subject , the method including the step of supporting a vessel associated with the organ or anatomical region . the devices and methods may be used to deliver , remove or recirculate a therapeutic agent to an organ or anatomical region .