the invention provides a method for controlling actuation of label particles in a biosensor device , in particular a biosensor device using frustrated total internal reflection . by applying a predetermined actuation force on the label particles and determining the effect of the applied actuation force in a binding volume or surface of a sensor cartridge of the biosensor device , a feedback control of the actuation force is applied . furthermore , a biosensor device is provided which is adapted for forming the method according to the invention .