painless , non - invasive nanofluidic delivery systems useful for the delivery of therapeutically active agents , gras agents , sterile fluids and inert fillers through epithelial membranes are described . the painless , non - invasive delivery system delivers a therapeutic agent via a micro - syringe - based assembly . the painless , non - invasive delivery system may also have a vehicle , which facilitates the absorption of the therapeutic agents by altering its absorption rate at the site of administration . also disclosed is a method and components of the delivery system to administer therapeutic agents in a consistent , predictable and reproducible manner . certain compositions may facilitate the delivery of different agents without altering the agents from their current or previous form .