present invention provides a method for screening drug - induced toxicity and screening for drug - induced toxicity by using the nat2 , cyp2e1 and xanthine oxidase genes , in particular , provides a method for screening tb drug - induced hepatotoxicity . the method of present invention includes providing test specimen , detection of at least one type of snps of the nat2 , cyp2e1 and xanthine oxidase genes from the dna of said test specimen ; presence of the snp genotype indicates the test specimen has a risk for developing anti - tb drug - induced toxicity ; said snp genotype is selected from at least one of the following groups or their combinations thereof : rs1041983 , rs1112005 , rs1495741 , rs1799930 , rs1799931 , rs1801280 , rs1961456 , rs2087852 , rs11996129 , rs2031920 , rs2249695 , rs3813865 , rs3813867 , rs1884725 , rs2295475 and rs17011368 . moreover , the screening method of the invention includes the test specimen , detection of at least one type of snps of the xanthine oxidase gene from the dna of said test specimen ; presence of the snp haplotype indicates the test specimen has a risk for developing high uric acid and its related diseases ; said snp genotype is selected from at least one of the following groups or their combinations thereof : rs1884725 , rs2295475 and rs17011368 .