disclosed are a 3 - furyl - 2 - cyano - 2 - acrylamide derivative with epidermal growth factor receptor inhibitory activity and pharmaceutical acceptable salt thereof , together with preparation method thereof , pharmaceutical composition comprising the compound , and application of the compound in treating senile dementia . the new compound is shown as formula i , wherein r 1 is selected from the group consisting of h , c 1 - c 6 alkyl , c 2 - c 6 alkenyl , c 2 - c 6 alkynyl and c 3 - c 6 cycloalkyl ; r 2 is selected from the group consisting of alkyl , cycloalkyl , alkenyl , alkynyl , aryl , heteroaryl , aralkyl and heteroaralkyl ; x is selected from the group consisting of ch 2 , nh , o and s ; m and n are all integers greater than or equal to zero .