a prodrug comprising a heparin and a drug is provided . the prodrug can be used to form a coating on a medical device . the prodrug can also be used with a polymeric material to form a coating on a medical device . the polymeric material can be a hydrophobic polymer , a hydrophilic polymer , a non - fouling polymer , or combinations thereof . the medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis , thrombosis , restenosis , hemorrhage , vascular dissection or perforation , vascular aneurysm , vulnerable plaque , chronic total occlusion , claudication , anastomotic proliferation for vein and artificial grafts , bile duct obstruction , ureter obstruction , tumor obstruction , or combinations thereof .