the invention is directed to methods for the a method for treating overexpression of the erbb2 in a mammal in need of treatment by administering to the mammal a therapeutically effective amount of a first inhibitor of an erbb2 receptor and then , after an interval of less than 24 hours , administering to the mammal from one to six therapeutically effective amounts of the same or different inhibitor of the erbb2 receptor . the invention is also directed to a slow daily infusion of the erbb2 inhibitor . the overexpression of the erbb2 receptor can result in abnormal cell growth and lead to cancer . by the methods of the invention , the efficacy and safety of the inhibitors is increased . the invention is also directed to kits for facilitating the dose administration method of the invention .