the present invention relates to novel compounds selected from substituted oxazole derivatives of formula that selectively modulate , regulate , and / or inhibit signal transduction mediated by certain native and / or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative , metabolic , allergic , and degenerative disorders . more particularly , these compounds are potent and selective c - kit , bcr - abl and fit - 3 inhibitors .