methods for the transport and hybridization of a nucleic acid on an electrode device by providing a low conductivity buffer with a reducing agent to the device . the low conductivity buffer may also contain a zwitterion . a current and voltage is applied to a location of the device to effect electrophoretic transportation of the nucleic acid towards the location . the nucleic acid is then hybridized to a nucleic probed located at the location . the reducing agent in the low conductivity buffer may also be acting as a chaotropic agent .