aqueous solutions of diterpenes such as forskolin , its congeners , analogs and derivatives , up to approximately 6 % concentration , are prepared using suitably substituted cyclodextrin as a solubilizing agents . in the absence of cyclodextrin , some diterpenes such as forskolin are soluble in water only to concentrations of about 0 . 001 %. such aqueous solutions find applications in topical and systemic use , as pharmaceutical , cosmeceutical , nutraceutical preparations containing diterpenes such as forskolin and congeners .