methods and devices for providing a biopsy device with a modified handle and stylet that provides a vacuum to be delivered to the targeted tissue for removal . the vacuum may draw the tissue into the notch where the tissue may then be severed via the cannula . alternatively , the tissue may be drawn into to the notch after being severed via the stylet and / or cannula . the vacuum may be used to bring a larger amount of tissue into the notch than would otherwise be brought in the notch if no vacuum was used , providing a larger sample through the same size access point .