methods , devices and systems for acquiring information useful to support a patient in implementing and adhering to a medically prescribed therapy plan are provided . the therapy may incorporate biofeedback methods and / or personalized therapy aspects . a method includes steps of receiving , by a receiving device , biometric information associated with an ingestible event marker ; analyzing , by a computing device having a microprocessor configured to perform a biometric information analysis , the biometric information ; and determining a therapeutic recommendation at least partly on the basis of the analysis and / or integrating biofeedback techniques into patient therapy or activity . a system includes a biometric information module to receive biometric information associated with an ingestible event marker ; an analysis module to analyze the biometric information ; and a determination module to optionally determine and communicate a therapeutic recommendation at least partly on the basis of the analysis .