a crossflow filtration system including at least one quick dry change crossflow filtration cartridge designed to rotatably interface with a manifold assembly . the quick dry change crossflow filtration cartridge can comprise a membrane element , for example an ultrafiltration membrane , microfiltration membrane , nanofiltration membrane or reverse osmosis membrane element enclosed within a housing . the quick dry change cartridge includes an inlet stream , a permeate stream and a concentrate stream . the manifold assembly includes three similar flow paths ; an inlet stream , a permeate stream and a concentrate stream . when engaged , the cartridge and manifold assembly define continuous inlet flow paths , permeate flow paths and concentrate flow paths that connect across the interface . thus , all of the connections to the water filtration system can be made onto the manifold , and the resulting connected system is compact and easy to connect .