the present invention relates to the formulations of ester derivatives of capsaicin and ester derivatives of myristoleic acid . these derivatives are capable of reverting to the active parent compound following enzymatic or chemical hydrolysis . these derivatives have a higher lipophilicity , lipid solubility and less irritation to the skin than the parent compound , and hence are better able to be incorporated into certain pharmaceutical formulations , including cream and ointment pharmaceutical formulations . the pharmaceutical compositions are useful for pain management in mammals in vivo and have been contemplated to be used in the treatment of various pains in humans .