the present invention provides novel biomarkers for use in the diagnosis and prognosis of cancerous and malignant conditions and further of diseases which are mediated by a proinflammatory immune response . the biomarkers are glycoproteins , the levels of expression of which have been correlated by the inventors to correspond to particular disease conditions . the invention further extends to methods for use in monitoring the response to therapy of a treatment for use in the treatment of a cancerous condition or proinflammatory disease .