new polymorphs of 5 - amino or substituted amino 1 , 2 , 3 - triazole and substituted derivatives thereof , of orotates of the carboxyamidotriazoles , of formulations of the triazoles and orotic acid in the ratio of 1 : 1 to 1 : 4 and of safer processes of the preparation of the same are disclosed . the compounds are useful in the control and treatment of diseases including , but not limited to solid cancers , macular degeneration , retinopathy , chronic myeloid leukemia , aids and diseases which rely on aberrant signal transduction . the improved processes to prepare the orotate formulations use stable , efficient and safer starting azide intermediate materials in the synthesis of new polymorphs of carboxyamidotriazole .