the embodiments set forth herein provide biocompatible self - setting compositions suitable for use in tissue augmentation applications . the biocompatible self - setting compositions described herein exhibit advantageous theological properties and may be applied to a site in the body of a patient by injecting the composition through a 20 - 30 gauge needle . once applied to a site in the body , the composition sets to a slow resorbing or substantially non - resorbing matrix . advantageously , exposure of the composition material to body heat at its site of use enhances setting of the composition . composition materials prepared in accordance with the present disclosure may find use in applications involving , for example , soft tissue augmentation such as for dermal fold augmentation , prevention of adhesions , soft tissue void filling , soft tissue bleb creation , urethral sphincter augmentation for treatment of urinary incontinence , treatment of unilateral vocal fold paralysis , and lower esophageal sphincter augmentation for treatment of gastroesophageal reflux disease . in some embodiments , the presently described biocompatible compositions may serve as bone void fillers .