disclosed is a process of preparing blood spreads for microscopical examination wherein a smooth and homogeneous plasma layer is obtained . a combination of steps including timely fixation for the purpose of cell preservation , producing a cross - linked matrix in the plasma and performing of chemical reactions by diffusing reagents across an interface , are performed for the purpose of stabilizing both the cell shape and the smoothness and homogeneity of the plasma layer , while the fresh and still wet blood spread is immersed in a non - polar , water immisicible , solvent .