the present invention relates to novel kinase inhibitors and modulator compounds useful for the treatment of various diseases . more particularly , the invention is concerned with such compounds , kinase / compound adducts , methods of treating diseases , and methods of synthesis of the compounds . preferrably , the compounds are useful for the modulation of kinase activity of raf kinases and disease polymorphs thereof . compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma , colorectal cancer , ovarian cancer , papillary thyroid carcinoma , non small cell lung cancer , and mesothelioma . compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration .