processes and compositions are provided for regulating cox2 gene expression in a cell . the process includes selecting a polyamide composition comprising n - methyl pyrrole and n - methyl imidazole to provide specific binding to dna at a cox2 gene target site in a cell . the polyamide is then combined with the cell containing the cox2 gene , wherein the polyamide binds to the cox2 gene promoter target site and regulates transcription of the cox2 gene .