microstrain - inducing manifolds , systems , and methods are presented that involve microstrain - inducing manifolds that include a plurality of shaped projections for creating microstrain . the shaped projections may be tapered projections . a system may include a sealing member for placing over the tissue site , a microstrain - inducing manifold , and a reduced - pressure subsystem that delivers reduced pressure to the sealing member . the reduced pressure causes the shaped projections to create microstrain at the tissue site . other methods , apparatuses , and systems are also presented .