novel amines of formulas , , , and or a pharmaceutical acceptable salt thereof wherein n is an integer of from 0 to 2 ; m is an integer of from 0 to 3 ; r is sulfonamide , amide , phosphonic acid , heterocycle , sulfonic acid , or hydroxamic acid ; a ′ is a bridged ring selected from , , , , wherein is the point of attachment ; z 1 to z 4 are each independently selected from hydrogen and methyl ; o is an integer of from 1 to 4 ; and p is an integer of from 0 to 2 . in formula above r cannot be sulfonic acid when m is 2 and n is 1 are disclosed and are useful as agents in the treatment of epilepsy , faintness attacks , hypokinesia , cranial disorders , neurodegenerative disorders , depression , anxiety , panic , pain , neuropathological disorders , especially irritable bowel syndrome .