a biological specimen collection device comprises a specimen receptacle having a closed first end and an open second end . a removable conduit is provided for introducing a biological specimen into the receptacle and is connected to the second end of the receptacle . a base removably receives the first end of the receptacle and supports the receptacle in a substantially vertical position . a cap is removably connected to the base , this cap adapted to provide a liquid seal between the cap and the open second end of the receptacle . the cap is maintained in a protective environment during introduction of the biological specimen into the receptacle . access is permitted to the cap after the specimen has been collected for subsequently capping the open end of the receptacle with its contents .