the invention discloses pharmaceutical compositions containing polydatin or its pharmaceutically acceptable salts with the effect of improving microcirculation , and their application in preparing drugs which can improve microcirculation . the compositions are an non - gastrointestinal injection preparation , the preparation can be an aqueous solution which have ph 7 . 0 - 10 . 0 comprising 5 - 50 % propandiol . the dosage forms of the compositions may be lyophilizing powder injection , oral form , suppository of procto - administration and other forms of administrations comprising unguent , ointment , paste film coating and the like . the compositions may be used to treat and / or prevent diseases related to microcirculation blockage . the unit form may contain 1 - 1000 mg polydatin or its derivatives . the invention solves the problem of using polydatin to improve microcirculation . the composition of the invention can be used in treating shock , cardiac and cerebrovascular diseases , diseases of sense organs , diabetes complication , vaculitis related to blockage of blood vessel , hemorrhoid related to circulation obstruction , skin injury and burn .