phenoxyphenylacetic acids and derivatives of general structural formula i have endothelin ## str1 ## antagonist activity and are therefore useful in treating cardiovascular disorders , such as hypertension , congestive heart failure , postischemic renal failure , vasospasm , cerebral and cardiac ischemia , myocardial infarction , inflammatory diseases , raynaud &# 39 ; s disease , and endotoxic shock , and asthma .