the invention relates to the use of n - desulfated heparin for treating or preventing inflammation , which is based on the experimental results in animal acute abdominal inflammation model and animal bleed model . the n - desulfated heparin &# 39 ; s anti - inflammation activity is better than or equal to that of the low molecular weight heparin , and has low activity of anti - coagulant . from a series of n - desulfated heparin of different n - sulfur - containing , a sample of the best anti - inflammation activity and the lowest anti - coagulant activity was selected . the invention solved the problem of bleeding in the use of heparin for treating of inflammation , and provided a new pathway to use heparin to prevent and treat inflammation .