a method of processing a mammogram image to derive a value for a parameter useful in detecting differences in breast tissue in subsequent images of the same breast or relative to a control group of such images , said derived parameter being an aggregate probability score reflecting the probability of the image being a member of a predefined class of mammogram images , comprises computing for each of a multitude of pixels within a large region of interest within the image a pixel probability score assigned by a trained statistical classifier according to the probability of said pixel belonging to an image belonging to said class , said pixel probability being calculated on the basis of a selected plurality of features of said pixels , and computing said parameter by aggregating the pixel probability scores over said region of interest . said features may include the 3 - jet of said pixels .