disclosed are thienopyrimidinone derivatives as antagonists that act on metabotropic glutamate receptor subtype 1 . the thienopyrimidinone derivatives show pharmacological activity against metabotropic glutamate receptor - related diseases , including pain , such as neuropathic pain and migraine , psychiatric diseases , such as anxiety disorder and schizophrenia , urinary incontinence , and neurodegenerative diseases , such as parkinson &# 39 ; s disease and alzheimer &# 39 ; s disease . also disclosed are methods for preparing the thienopyrimidinone derivatives , and pharmaceutical compositions containing the thienopyrimidinone derivatives as active ingredients .