a topical hyperbaric apparatus and method is disclosed . the apparatus comprises a shell having at least one flexible wall portion which provides an external surface and defines a substantially closed internal chamber . the wall portion has an opening therethrough communicating with the internal chamber . the flexible wall portion is sufficiently flexible so as to be capable of conforming to an irregularly shaped surface of a patient &# 39 ; s body . an adhesive sealing material is provided on the flexible wall portion for adhesively sealing the shell to the patient &# 39 ; s body about the portion to be treated . a gas impermeable liner lines the internal chamber and makes the internal chamber substantially gas impermeable . therapeutic gases are introduced into the internal chamber to therapeutically treat a portion of the patient &# 39 ; s body encompassed by the opening .