the present invention relates to a dietary supplement , composition , nutraceutical , and / or system for inducing or treating biological responses or conditions which utilize ultra - low dosage amounts of vitamins , minerals , amino acids , co - enzymes , stimulants , and / or similar ingredients in a highly bio - active delivery system which bypasses first pass metabolism . in particular , the present invention relates to a nutraceutical composition / formulation which substantially bypasses first pass metabolism and such as , but not limited to , activation of the glymphatic system to facilitate clearance of neuronal metabolites from the csf and interstitial fluids in the brain .