this invention provides a rp - hplc method , for the determination of logp oct values , which combines ease of operation and high accuracy , and which has been shown to work for a set of 36 molecules largely comprised of drugs . the general features of the method are : i ) compound sparing , ii ) rapid determinations , iii ) low sensitivity to impurities , iv ) wide lipophilicity range , v ) good accuracy , vi ) excellent reproducibility . a linear free energy relationship analysis , based on solvation parameters , shows that the method encodes the same information obtained from a shake - flask logp oct determination . the value generated via this method is referred to as elogp oct .