biopsy of the prostate using 2d transrectal ultrasound guidance is the current gold standard for diagnosis of prostate cancer ; however , the current procedure is limited by using 2d biopsy tools to target 3d biopsy locations . we have discovered a technique for patient - specific 3d prostate model reconstruction from a sparse collection of non - parallel 2d trus biopsy images . our method can be easily integrated with current trus biopsy equipment and could be incorporated into current clinical biopsy procedures for needle guidance without the need for expensive hardware additions . we have demonstrated the model reconstruction technique using simulated biopsy images from 3d trus prostate images of 10 biopsy patients . this technique of model reconstruction is not limited to the prostate , but can be applied to the reconstruction of any tissue acquired with non - parallel 2 - dimensional ultrasound images .