a pharmaceutical composition , containing as active principle cyclobenzaprine hydrochloride , 3 - cyclo - epten - 5 - yliden )- n , n - dimethyl - 1 - propanamine hydrochloride , in form suitable to be administered by itranasal route , is described . said pharmaceutical composition allows a remarkable absorption rapidity of the active principle , does not undergo the first hepatic passage , has an excellent tolerability with low tonicity formulations and does not show any contraindication in the short period administrations .