this invention relates to a method for treating persistent pain disorders by inhibiting the biochemical mediators of inflammation in a subject comprising administering to said subject a therapeutically effective dosage of said inhibitor . said process for treating persistent pain disorders is based on sota omoigui &# 39 ; s law , which states : the origin of all pain is inflammation and the inflammatory response . biochemical mediators of inflammation that are targeted for inhibition include but are not limited to : prostaglandin , nitric oxide , tumor necrosis factor alpha , interleukin 1 - alpha , interleukin 1 - beta , interleukin - 4 , interleukin - 6 and interleukin - 8 , histamine and serotonin , substance p , matrix metallo - proteinase , calcitonin gene - related peptide , vasoactive intestinal peptide as well as the potent inflammatory mediator peptide proteins neurokinin a , bradykinin , kallidin and t - kinin .