in various embodiments , methods and compositions for treating raynaud &# 39 ; s disease and raynaud &# 39 ; s phenomenon are provided . topical administration of a semisolid composition comprising a prostaglandin e1 compound provides the desired relief of the raynaud &# 39 ; s disease or raynaud &# 39 ; s phenomenon without the possible complications of systemic administration . the semisolid composition can be administered as needed , or in a regimen of several doses per day .