this invention provides compositions and methods related to the administration of red yeast rice , coenzyme q 10 , and chromium , with or without inositol hexanicotinate , selenium , and mixed tocopherols to reduce or control blood cholesterol , triglycerides , low density lipoproteins , or increasing or controlling high density lipoproteins in a mammal , to reduce arterial plaque build - up , atherosclerosis , in a mammal which may be associated with cardiovascular , cerebrovascular , peripheral vascular , or intestinal vascular disorders .