a method for formulating a glucose oxidase enzyme with peroxide resistant properties and a glucose oxidase enzyme formulated by the method . the enzyme formulation method results in a glucose oxidase enzyme with improve resistance to peroxide , and therefore , with improved resistance to oxidative inactivation . the method employs directed evolution techniques to evolve glucose oxidase to achieve the desirable properties . a peroxide resistant glucose oxidase may improve the longevity of , for example , glucose biosensors in which a peroxide resistant glucose oxidase may be placed .