novel substituted pyrazolidinones have been found to exhibit significant binding to cholecystokinin receptors and gastrin receptors in the brain and / or peripheral sites such as the pancreas , stomach , and ileum . the pyrazolidinones are cck and gastrin receptor antagonists and find therapeutic application in the treatment of gastrointestinal disorders , central nervous system disorders and for appetite regulation in warm - blood vertebrates . pharmaceutical formulations for such indications are described .