this invention belongs to the technical field of quantitative structure - activity relationship for chemical persistent assessment , relating to a method for predicting reaction rate constants of organic chemicals with ozone at different temperatures . to assess the persistence and fate of organic chemicals in the troposphere , k o3 are needed . this invention developed a qsar model for the prediction of k o3 at different temperatures , based on quantum chemical descriptors , dragon descriptors and structural fragments . the developed model was evaluated by internal and external validations , and it &# 39 ; s high robustness and good predictability was evidenced . the applicability domain of this model was visualized by williams plot .