a chromatographic process for the enrichment of at least one compound of interest from a mixture is proposed , using chromatographic columns , wherein said process involves a sequence of the following steps : a cyclic accumulation phase , in which the chromatographic columns are alternatingly operated in an interconnected phase , followed by a disconnected phase , wherein subsequently columns exchange places and wherein the phases are carried out sequentially ; a cyclic separation phase , in which the chromatographic columns are alternatingly operated in an interconnected phase , followed by a disconnected phase , wherein after these phases columns exchange places to undergo the next interconnected and disconnected phases ; and an elution phase , in which from the column , which at the end of phase or at the end of phase contains the compound of interest , is extracted via the outlet .