a peritoneal dialysis system includes : a fluid cassette including diaphragm operated first and second pump chambers ; a first pressure sensor operable with the first pump chamber ; a second pressure sensor operable with the second pump chamber ; and a to - patient port of the cassette in fluid communication with the first and second pump chambers , wherein the first pressure sensor is located between the first pump chamber and the to - patient port and the second pressure sensor is located between the second pump chamber and the to - patient port .