a method and pharmaceutical composition are described for treatment of acne vulgaris which comprises administering to a patient suffering from acne vulgaris an effective amount of a pharmaceutical composition comprising pantothenic acid or a derivative thereof which generates pantothenic acid in the body to form coenzyme a , nicotinic acid or a derivative thereof which generates nicotinamide adenine dinucleotide or nicotinamide adenine dinucleotide phosphate in the body , and biotin , or a mixture thereof .