certain simple chemical agents , referred to herein as nitrone related therapeutics or “ nrts ”, when administered to a patient susceptible to neovascularization , can intervene and inhibit the disease &# 39 ; s progress . methods for therapeutically and prophylactically inhibiting angiogenesis by administering one or more nrts are disclosed as are pharmaceutical compositions for use in such methods of treating . nrts useful in these compositions and therapeutic methods are also disclosed .