to increase the solubility of acidic medicines a high concentration solvent system to be encapsulated comprises a ) 10 - 80 % by weight acidic medicine , b ) 0 . 1 - 1 . 0 mole hydroxide ions for one mole equivalent of said medicine , and c ) 1 - 20 % by weight water . included in polyoxyethylene sorbitan fatty acid ester as the solvent .