a system , method and computer readable medium of instructions are provided which are useful for determining whether an evaluation testing method or device is clinically equivalent to a reference testing method or device . the report can include a modified mean difference plot , a variability chart , confidence intervals for bias and a plot of the intervals . a graphical user interface is provided to allow data associated with the reference and evaluation methods or devices to be identified . a level of variance in the reference method is determined . an observed bias between the evaluation methods or devices and the reference methods or devices is calculated . a confidence interval for the bias is calculated . the biases between the evaluation methods or devices and reference method or device is compared relative to the level of variance in the reference method , and a report is generated including a conclusion about whether the evaluation methods or devices are clinically equivalent to the reference method or device .