there is disclosed an initial identification of an n - terminally truncated her - 2 / neu product . this product is a 95 kda polypeptide having in vitro kinase activity . moreover , immunoprecipitations using domain specific antibodies was able to utilize this specific polypeptide from intracellular fragments as a diagnostic and prognostic indicator of adenomacarcinomas without the severe dilution effects encountered by measuring ecd .