pharmaceutical compositions and a method for immunization of mammals against atherosclerosis including steps of a ) obtaining blood from a mammal ; b ) isolating low density lipoprotein from the blood ; c ) fusing the lipoprotein in vitro to obtain heavy microemulsion lipoprotein fusion particles having new antigenic determinants ; d ) administering the fusion particles obtained in step to a mammal ; and e ) allowing the immune system to clear fusion lipoprotein particles from the mammal .