a method of simultaneously collecting exocervical and endocervical cells from a female patient , includes providing a combination exo - endocervical sampling device including a sampler having a pair of opposing wings and a prominence extending from the wings . the opposing wings include a sampling surface and the prominence includes a multiplicity of endless looped fiber pairs distributed axially along a distal end section of the prominence . each looped fiber pair includes a first loop extending transverse from the shaft and a second loop extending transverse from the shaft . the loops define a void space therebetween configured to capture exo - endocervical cells . the method includes placing the sampling device in contact with a cervix of the female patient , collecting exocervical cells with the opposing wings of the sampling device , and simultaneously collecting endocervical cells with the prominence .