the present invention discloses a method for treating or preventing a bone disorder in a mammal in need thereof comprising orally administering to said mammal a pharmaceutically effective amount of a pharmaceutical composition of at least one bisphosphonate , or a pharmaceutically acceptable salt or esters thereof , and at least one aminoalky methacrylate copolymer , according to a dosing schedule having a dosing interval selected from once - weekly dosing , twice - monthly dosing , once - monthly , once - quarterly and once - annually dosing . the present invention further discloses a method for treating or preventing a bone disorder in a mammal in need thereof comprising continuously orally administering a unit dosage per - day to said mammal in a short time for a long time therapy .