methods of synthetically producing , formulating and using secretoglobins scgb1a1 , scgb3a2 , and scgb3a1 are provided . methods of using secretoglobins scgb1a1 , scgb3a2 , and scgb3a1 as therapeutic agents to affect long term patient outcomes , such as preventing severe respiratory exacerbations of underlying conditions that require medical intervention , including hospitalization are provided . methods of producing recombinant human secretoglobins , analytical methods , pharmaceutical compositions , and methods of use to prevent the long term sequelae of acute and chronic respiratory conditions are provided .