a stable solution cream , salve , or spray composition containing activated stabilized chlorine dioxide and phosphates , such as disodium hydrogen phosphate , sodium dihydrogen phosphate , trisodium phosphate , and sodium monofluorophosphate , is disclosed for the prevention and treatment of abnormal conditions of the epithelium of bodily orifices . examples of such abnormal conditions of the epithelium of the rectal , vaginal , urethral , oral , nasal , ocular , and auditory canal orifices include bacterial infections , such as actinobacillus actinomycetemcomitans and porphyromonoas gingivalis , and fungal infections , such as candida , and leukoplakia . the preferred concentration ranges are between about 0 . 005 %- 2 . 0 % chlorine dioxide , and between about 0 . 02 %- 3 . 0 % phosphate . the phosphate compound retards escape of chlorine dioxide in the ph range of 6 . 0 to 7 . 4 , at which ph stabilized chlorine dioxide becomes activated and releases sufficient chlorine dioxide to reduce motility and become lethal to the involved micro - organisms .