disclosed are means , methods , and compositions of matter useful for generation of cancer inhibitory effector cells producing interleukin - 17 . in one embodiment a cellular population is obtained , said cellular population is exposed to agents capable of inhibiting nr2f6 , whereby said inhibition of nr2f6 results in upregulation of il - 17 production , said upregulation of il - 17 production associated with acquisition of anti - tumor activity .