a surgical cassette for use in a combined anterior segment and posterior segment ophthalmic surgical procedure is disclosed . the surgical cassette includes an irrigation inlet for receiving irrigation fluid from a source , a first irrigation outlet for providing irrigation fluid to a first ophthalmic microsurgical instrument , a first manifold fluidly coupling the irrigation inlet with the first irrigation outlet , a second irrigation outlet for providing irrigation fluid to a second ophthalmic microsurgical instrument , and a second manifold fluidly coupling the irrigation inlet with the second irrigation outlet . the surgical cassette greatly simplifies the combined procedure by eliminating the need for separate anterior segment and posterior segment cassettes for the combined procedure .