 <p>Chrome (or any other browser) doesn't support HTAs at all. Actually HTAs are run by mshta.exe, and IE is used as a rendering &amp; scripting engine.</p> <p>When HTA is run with IE9 (<code>&lt;meta http-equiv="x-ua-compatible" content="IE=9"&gt;</code>) there are some issues with <code>&lt;HTA: application&gt;</code>, like some mess with <code>icon</code> and window borders.</p> <p>With IE10 (<code>&lt;meta http-equiv="x-ua-compatible" content="IE=edge"&gt;</code>) it seems, that HTA properties are ignored totally, even <code>singleInstance="yes"</code> doesn't work. If you take a look at a runtime source, you can see the <code>&lt;HTA: application&gt;</code> tag is moved to the <code>body</code>, where it has not the expected influence.</p> <p>All above written about IE is related to the actual HTA properties only, all HTML, scripts and privilegs work well. With IE10 even better and faster than ever before, and you can use real JavaScript instead of JScript.</p> <p>To utilize all available features, you need to add document type and <code>x-ua-compatible</code> to your pages:</p> <pre><code>&lt;!DOCTYPE html&gt; &lt;html&gt; &lt;head&gt; &lt;title&gt;&lt;/title&gt; &lt;meta http-equiv="x-ua-compatible" content="IE=edge"&gt; ... </code></pre>