 <p>The issue is that your app does not have a module named <code>uwsgi</code>. You change the directory to <code>/home/user/appname</code> but it looks like the actual module would be <code>appname.uwsgi</code> since the <code>uwsgi.py</code> file lives within <code>/home/user/appname/appname/uwsgi.py</code>.</p> <p>Typically though, you don't need to specify both <code>--wsgi-file</code> and <code>--module</code> so I would either do</p> <pre><code>uwsgi --http :9010 --chdir /home/user/appname --wsgi-file /home/user/appname/appname/wsgi.py </code></pre> <p>or</p> <pre><code>uwsgi --http :9010 --chdir /home/user/appname --module appname.uwsgi </code></pre> <p>I personally prefer the second.</p>