 <p>While I'm not install expert, I've used Wix successfully. It's complicated to say the least.</p> <p>I don't see any of these products being mentioned that I've seen clients use successfully. </p> <p><a href="http://www.installaware.com/" rel="nofollow">http://www.installaware.com/</a> http://www.flexerasoftware.com/products/installshield.htm <a href="http://www.wise.com/Products/Installations/WiseInstallationStudio.aspx" rel="nofollow">http://www.wise.com/Products/Installations/WiseInstallationStudio.aspx</a></p> <p>All provide localization, file/app for double click association, Framework bootstrapping and target location to the best of my knowledge. InstallAware and Wise provide some form of autoupdate support.</p>