 <p>From the Apple iOS 6.0 release notes:</p> <p>"In general, Auto Layout considers the top, left, bottom, and right edges of a view to be the visible edges. That is, if you pin a view to the left edge of its superview, you’re really pinning it to the minimum x-value of the superview’s bounds. Changing the bounds origin of the superview does not change the position of the view.</p> <p>The UIScrollView class scrolls its content by changing the origin of its bounds. To make this work with Auto Layout, the top, left, bottom, and right edges within a scroll view now mean the edges of its content view."</p> <p>You can find the <a href="http://developer.apple.com/library/ios/#releasenotes/General/RN-iOSSDK-6_0/index.html" rel="nofollow">full notes here</a> and find the answer to your question in the section that I quoted from. They give code examples on how to use UIScrollView in a mixed Auto Layout environment.</p>