 <p>I am personally using Orbited, both because I am already using Twisted and because it seems mature. Twisted has a nice long history with many users, especially in comparison to Diesel and Tornado. Orbited is indeed built on Twisted.</p> <p>There is a good blog entry covering an <a href="http://cometdaily.com/2008/10/10/scalable-real-time-web-architecture-part-2-a-live-graph-with-orbited-morbidq-and-jsio/" rel="nofollow noreferrer">end-to-end orbit solution here</a>. It sends data from a python script to a STOMP server (MorbidQ) to Orbited to Javascript - rendering that data as a graph.</p> <p>Tornado seems pretty new to the scene, I couldn't find twisted-comet and I hadn't heard of diesel. I particularly like the way that Orbited can forward any sort of tcp/ip but makes it easy to hook javascript clients in with a message passing STOMP backend.</p>