 <p>This does sound like you're asking for opinion rather than a definitive answer - so....</p> <p>As someone who develops little fun apps and some work related tooling in VB6 (more of an interest/hobby, than anything else), my opinion is that it's perfectly fine to run in Win7 x64. I find it more convenient to run it on my main desktop than in a VM. However, I've also installed VB6 on a W2k3 VM as some more obscure bugs (often around MDAC) can't be fully tested/circumvented in Win7. </p> <p>Oh, and I always run the IDE As Administrator to avoid some other niggles</p>