 <p>Cocos2d can support isometric maps. To get started with Cocos2d, there is nothing better than <a href="http://www.raywenderlich.com/1163/how-to-make-a-tile-based-game-with-cocos2d" rel="nofollow">Ray Wenderlich's multiple part tutorial</a>! It doesn't cover isometric projections, but you'll still need to know the basics of cocos2d.</p> <p>Note that Cocos2d is open source and, thus, you could study the source to see how it implements isometric projections if you decide to roll your own solution.</p>