 <p>The main problem is C run-time library. Python 2.4/2.5 linked against msvcr71.dll and therefore all C-extensions should be linked against this dll.</p> <p>Another option is to use gcc (mingw) instead of VS2005, you can use it to compile python extensions only. There is decent installer that allows you to configure gcc as default compiler for your Python version:</p> <p><a href="http://www.develer.com/oss/GccWinBinaries" rel="nofollow noreferrer">http://www.develer.com/oss/GccWinBinaries</a></p>