 <ol> <li>normally, the start button will enabled when selecting the genymotion device.</li> <li>if not, verify that whether the genymotion's sdk is same as that of android studio or not.</li> </ol> <p><em>Genymotion -> Setting -> ADB</em></p> <p>if it is, <strong>Use Genymotion Android tools</strong>. then change to <strong>Use custom Android sdk tools</strong>. and locate the sdk location.</p> <p><a href="https://i.stack.imgur.com/pVUtL.png" rel="nofollow noreferrer"><img src="https://i.stack.imgur.com/pVUtL.png" alt="screen shot"></a></p> <p>to know the sdk location,</p> <p><em>Android studio -> Preferences -> Appearance and behaviour -> System settings -> Android sdk -> Android sdk location</em></p> <p><a href="https://i.stack.imgur.com/mjXlD.jpg" rel="nofollow noreferrer"><img src="https://i.stack.imgur.com/mjXlD.jpg" alt="enter image description here"></a></p>