 <p>See <a href="http://pandas.pydata.org/pandas-docs/stable/indexing.html#multiindexing-using-slicers" rel="nofollow">here</a> for multiindex using slicers, introduced in 0.14.0</p> <pre><code>In [36]: idx = pd.IndexSlice In [37]: df.loc[:, idx[:, ['j', 'k']]] Out[37]: c d e f j j k k 0 0.750582 0.877763 0.262696 0.226005 1 0.025902 0.967179 0.125647 0.297304 2 0.463544 0.104973 0.154113 0.284820 3 0.631695 0.841023 0.820907 0.938378 </code></pre>