It is a first call-up for the 19-year-old midfielder, who recently joined Italian Serie A side Bologna.
Swansea midfielder Andre Ayew is also in Grant's 24-man group, recalled after missing the win over Mauritius in June.
Ghana and Rwanda, joint top in Group H on three points, go head-to-head on 5 September in Kigali.
Full squad:
Goalkeepers: Razak Braimah (Cordoba, Spain), Fatau Dauda (AshGold), Richard Ofori (Wa All Stars)
Defenders: Harrison Afful (Columbus Crew, USA), John Boye (Sivasspor, Turkey), Jonathan Mensah (Evian, France), Jeffery Schlupp (Leicester City, England), Baba Rahman (Chelsea, England), Gyimah Edwin (Orlando Pirates, South Africa), Daniel Amartey, (FC Copenhagen, Denmark)
Midfielders: Rabiu Mohammed (Krasnodar, Russia), Emmanuel Agyemang-Badu (Udinese, Italy), Afriyie Acquah (Torino, Italy), Solomon Asante (T.P. Mazembe, DR Congo), Christian Atsu (Bournemouth, England), Andre Ayew (Swansea City, UK) Mubarak Wakaso (Rubin Kazan, Russia), Bernard Mensah (Getafe, Spain), Godfred Donsah (Bologna, Italy)
Strikers: Asamoah Gyan (SIPG Shanghai, China), Jordan Ayew (Aston Villa, England), Ebenezer Assifuah (Sion, Switzerland), David Accam (Chicago Fire, USA), Richmond Boakye Yiadom(Atalanta, Italy).
Ghana boss Avram Grant has included uncapped Godfred Donsah in his squad to play a 2017 Africa Cup of Nations qualifier against Rwanda.