Coach Rowland Phillips drafts in scrum-half Sian Moore, wing Jasmine Joyce, centre Gemma Rowland and full-back Elinor Snowsill.
Wales have lost their last three matches, but were much-improved in the 12-7 defeat by Ireland.
"There are only small parts of our game that need improving. We didn't want to make drastic changes," said Phillips.
"The players showed the right amount of attitude and desire last Saturday in Cardiff, which we want them to carry into this weekend's game."
There are 12 players in the match day squad who features in the 10-8 win over France in Neath last season.
Full-back Dyddgu Hywel and wing Elen Evans are unavailable this weekend due to injuries sustained in the match against Ireland.
Elinor Snowsill (Newport Gwent Dragons); Jasmine Joyce (Scarlets), Gemma Rowland (Newport Gwent Dragons), Rebecca De Filippo (Newport Gwent Dragons), Adi Taviner (Ospreys); Robyn Wilkins (Ospreys), Sian Moore (Newport Gwent Dragons); Caryl Thomas (Scarlets), Carys Phillips (c) (Ospreys), Amy Evans (Ospreys), Rebecca Rowe (Newport Gwent Dragons), Mel Clay (Ospreys), Sioned Harries (Scarlets), Rachel Taylor (Scarlets), Shona Powell-Hughes (Ospreys).
Replacements Lowri Harries (Scarlets), Cerys Hale (Newport Gwent Dragons), Catrin Edwards (Scarlets), Siwan Lillicrap (Ospreys), Alisha Butchers (Scarlets), Keira Bevan (Ospreys), Jodie Evans (Scarlets), Jessica Kavanagh-Williams (Scarlets).
Wales Women field a team showing four changes for their final Six Nations match against France in Brive.