Emergency services were called at 00:15 GMT to the A146 at Beccles, Suffolk.
Police said no-one was trapped following the crash, near the roundabout near Morrisons supermarket.
Three people were taken to the James Paget Hospital, and others were treated at the scene. The coach was removed and the road re-opened at 03:45 GMT.
A coach with 24 people on board crashed off a road into a ditch in the early hours leaving three needing hospital treatment.