The truck - a Ford Transit - collided with a Peugeot 206 which was being followed by an unmarked police car in Leicester on 9 March.
David Anger and Christopher Needham, who were both passengers in the car, died at the scene, on Fosse Road South.
Guy Tomlinson, 37, has been charged with six motoring offences in total.
Mr Tomlinson, of Norfolk Walk, Leicester, faces two counts of causing death by dangerous driving, two charges of causing death by driving while uninsured and two counts of causing death by driving while unlicensed.
He will appear at Leicester Magistrates' Court later.
The Independent Police Complaints Commission is investigating the crash.
A man has been charged with causing the deaths of two people by dangerous driving after a crash between a car and a tipper truck.