Marcel Addai, 17, was found with stab wounds on 4 September on the St John's Estate in Pitfield Street, Hoxton. He was pronounced dead at the scene.
Sodiq Adebayo, 22, from West Sussex, will appear in Hendon Magistrates' Court in north London on Saturday.
Akeem Gbadamosi, 21, and Eugene Ocran, 19, have already been charged with murder.
Met Police officers attended the scene of the incident on Friday evening, one week after he died, to continue to appeal for witnesses.
A third man has been charged with murder following the death of a teenager on an east London estate.