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26 April 2015 Last updated at 14:23 BST
Rescue teams will be trying to help people who are trapped and injured, and provide shelter and protection to those who have lost their homes.
Many countries, including America, Pakistan, China and India, have promised aid like food supplies, tents, doctors and search and rescue helicopters.
Newsround spoke to one UK charity which is sending shelter material to help people whose homes have been damaged or destroyed by the earthquake.
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Countries and charities from around the world are helping Nepal deal with the aftermath of the powerful earthquake that struck there on Saturday.