California-based Cloudwick Technologies offers services such as cyber security, data storage and business intelligence.
It chose Glasgow after being awarded a Â£500,000 Scottish Enterprise grant.
Cloudwick said the Glasgow office would allow it to service existing US clients' European operations and seek new opportunities for growth.
Harshdeep Singh, director of operations for Cloudwick, said: "We are excited to begin our European journey from Scotland.
"The support from Scottish development International and Scottish Enterprise will help us build and enrich the wider ecosystem and create a much stronger success story from Scotland."
Economy Secretary Keith Brown said: "Cloudwick is joining a number of international companies who have chosen to invest and expand in Scotland, attracted by our diverse business base and our highly skilled workforce.
"I welcome Cloudwick's expansion into Scotland and the exciting employment opportunities they are creating in Glasgow."
A US data management firm is expected to create 58 new jobs in Glasgow after selecting the city as the location for its European headquarters.