Hong Kong made 120-7 off their 20 overs in Dharamsala, with Ireland reaching 122-0 in reply off just 12.2 overs.
Captain William Porterfield thrashed 75 not out off 36 balls, with fellow opener Andrew Balbirnie unbeaten on 47.
Mark Chapman top-scored for Hong Kong with 64 not out, the only man to pass 20, while seamer Tim Murtagh was the pick of Ireland's bowlers with 2-21.
Max Sorensen, Boyd Rankin and Andrew McBrine took one wicket apiece for the Irish at the HPCA Stadium.
Earlier at the same venue, Zimbabwe suffered a humiliating seven-wicket defeat at the hands of local side Himachal Pradesh Cricket Association XI.
Ireland play Zimbabwe in their next warm-up game on Saturday, before beginning their World T20 campaign against Oman in Dharamsala on 9 March.
Ireland beat Hong Kong by 10 wickets in their first official warm-up game ahead of the ICC World Twenty20 in India.