The fourth seed, 22, faces Slovakian Anna Karolina Schmiedlova, while 2015 finalist Lucie Safarova begins her campaign against Vitalia Diatchenko.
The Czech, 29, was runner-up to world number one Serena Williams last year.
British number two Heather Watson, 24, plays American Nicole Gibbs, with Kyle Edmund facing Georgia's Nikoloz Basilashvili in the men's draw.
The 21-year-old Briton, ranked number 84 in the world, retired hurt from his first-round match at the Nice Open last week.
Japanese fifth seed Kei Nishikori, 26, will be second on the Philippe-Chatrier Court at Roland Garros against Italian Simone Bolelli.
That follows women's 10th seed Petra Kvitova's opener against Montenegro's Danka Kovinic.
Canadian eighth seed Milos Raonic and Australia's Nick Kyrgios also feature in the men's draw, while Romanian world number six Simona Halep and Russia's Svetlana Kuznetsova get under way in the women's section.
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Spain's Garbine Muguruza will be the highest-ranked player in action on the first day of the French Open on Sunday.