24 July 2015 Last updated at 18:58 BST
In 2006, he visited Kenya as Senator, but this will be the first time in his presidency that he enters his father's homeland.
When he came to power in 2009, there were high hopes for relations between Africa and the US, but has President Obama delivered?
BBC Africa takes a quick look at Mr Obama and his relationship with the continent.
Produced by Baya Cat
Barack Obama is making his fifth trip to Africa as US president.