US shares jumped on Wednesday after hints from the Federal Reserve that interest rates could rise in December.
But on Thursday, the Dow Jones eased 0.02% to 17,732.75 points, while the S&P 500 lost 0.11% to 2,081.24. The Nasdaq shed 0.03% to 5,073.64.
Intel led the Dow's risers, up 3.44% after announcing a dividend hike.
The S&P healthcare sector was the worst performer among the 10 major sector on the index with a 1.63% fall. Drugmaker Pfizer fell 3.06% after reports that its talks to buy Allergan and re-domicile in Ireland were in final stages. Allergan lost 2.82%.
Electronics retailer Best Buy dropped 2.11% after its third-quarter revenues fell below analysts' expectations.
Revenues fell 2.4% to $8.82bn, although profits rose 16.8% to $125m.
(Close): Wall Street's main markets edged lower, with rises in technology stocks offset by falls in healthcare shares.