Hooker Richard Hibbard and prop John Afoa return as David Humphreys makes 10 changes to the team which beat the French side 35-14 on 8 December.
Lewis Ludlow, Jacob Rowan and Ben Morgan also start in the pack, while Callum Braley starts at scrum-half.
James Hook takes David Halaifonua's spot at full-back, with Jonny May and Charlie Sharples on the wings.
Stade Rochelais: Murimurivalu; Lacroix, Jordaan, Aguillon, Rattez; James, Bales; Corbel, Forbes, Atonio, Qovu, Tanguy, Sazy, Eaton (capt.), Vito.
Replacements: Maurouard, Priso, Boughanmi, Cedaro, Francoz, Retiere, Holmes, Botia.
Gloucester: Hook; Sharples, Scott, Atkinson, May; Burns, Braley (capt.); Hohneck, Hibbard, Afoa, Savage, Thrush, Ludlow, Rowan, Morgan.
Replacements: Matu'u, Thomas, Doran-Jonesm Latta, Galarza, Heinz, Purdy, Kvesic.
For the latest rugby union news follow @bbcrugbyunion on Twitter.
Gloucester lock Jeremy Thrush will make his first appearance of the season against Stade Rochelais.