They were hit by the silver van on the A25 Reigate Road in Dorking, near the junction of Pixham Lane, at about 18:50 BST on Friday.
A man died at the scene while a woman was taken to St George's Hospital in London where she was pronounced dead, Surrey Police said. The force described the two victims as elderly.
The road was closed for officers to investigate but has since reopened.
Police are appealing for witnesses.
Two pedestrians have been run over and killed by a van in Surrey.