The man was driving a Ford Focus when it was involved in a crash with a Renault Traffic van near to Knowesouth Steading, Jedburgh.
The incident took place on the Kelso to Denholm road at 21:20 on Saturday.
The road was closed for several hours for collision investigations. Police have appealed for witnesses.
Sgt Andy Gibb said: "Sadly this collision has resulted in a young man losing his life and we would like to ascertain the full circumstances of the collision."
A 24-year-old man has died after a two-car collision on the A698 in the Scottish Borders.