Claudio "Claude" Callegair, 53, from Broxted, Essex, was last seen at 11:30 BST on Thursday.
He regularly appears on ArsenalFan TV, which describes itself as "an online channel for all Gooners".
Essex Police said Mr Callegair's family were "extremely concerned for his welfare". Piers Morgan tweeted saying: "Hope he's ok".
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Mr Callegair was last seen getting into his work vehicle, a black Ford Galaxy taxi, registration LM64EKG, police said.
He is described as white, of large build, 5ft 10ins tall and is bald with brown eyes.
A taxi driver who became well known online after his regular appearances on an Arsenal fan site has gone missing.