The accident happened at about 10:00 on Sunday at Ringford near Castle Douglas.
A 24-year-old man from Wolverhampton driving the Citroen Picasso involved was taken to Dumfries Infirmary with a knee injury.
A 60-year-old woman and 74-year-old man from Kirkcudbright, travelling in a Fiat Doblo van, were also taken to the hospital with bruising.
The road at the scene was closed for some time to allow the vehicles to be recovered.
Three people required hospital treatment after a crash involving a car and a van on the A75 at the weekend.