The crash at junction 1 Bonnybridge happened at about 09:00 and involved an Asda lorry.
Pictures from Traffic Scotland's live cameras showed food strewn across the west-bound carriageway.
The lorry was removed but the road remained closed for several hours while debris was cleared. Diversions were in place.
Drivers on the M876 near Falkik have faced disruption after a supermarket delivery lorry overturned.