Media playback is not supported on this device
BBC boxing correspondent Mike Costello will be joined by pundit Steve Bunce for coverage of the light-middleweight bout.
There will also be live text commentary on the BBC Sport website and app.
Build-up begins with updates from the fighters' news conference on Wednesday and the weigh-in on Friday.
Get the biggest boxing news sent straight to your device. Find out more.
The contest between Irish UFC champion McGregor, 29, and 40-year-old five-weight champion Mayweather is set to be one of the richest in boxing history.
Mayweather will surpass fellow American Rocky Marciano's perfect record of 49 fights without defeat should he overcome McGregor.
UK radio listeners will be able to hear live commentary of Floyd Mayweather's fight against Conor McGregor from Las Vegas on Saturday on BBC Radio 5 live.