The incident, which involved two vans and a 4x4 that was towing a caravan, happened on the A91 at Mawcarse at about 15:15.
A 63-year-old van driver died as a result of his injuries. No-one else was injured.
The Scottish Fire and Rescue Service sent two appliances to the scene. A Police Scotland spokesman said investigations were ongoing.
Anyone who witnessed the incident is asked to contact Tayside Police on the 101 number.
A man has died after a three-vehicle crash in Perth and Kinross.