The bug struck the Claymore Hotel in the picturesque Argyll and Bute village on Thursday.
Fourteen of the hotel's guests were said to be affected, all of whom were elderly.
The affected guests, who were on a bus tour, have been provided with individual transport home.
Guests due to arrive at the weekend have been rerouted to other hotels on their tour.
The hotel said it hopes to reopen on Monday.
Arrochar, which sits on the banks of Loch Long, is a popular stop on bus tours.
A hotel in Arrochar has had to close for deep cleaning this weekend after an outbreak of norovirus.