Apple's annual revenue fell for the first time since 2001.
The Dow Jones closed up 30.06 points at 18,199.33.
The wider S&P 500 index fell 3.73 points to 2,139.43, while the Nasdaq index fell 33.13 points to 5,250.27.
Shares in aerospace giant Boeing rose 4.7% after it reported better-than-expected third-quarter profits.
The company earned $2.28bn in the quarter, compared with $1.70bn a year earlier, although revenues fell to $23.90bn from $25.85bn.
Coca-Cola shares fell 0.24% after third-quarter revenues fell for the sixth quarter in a row, down 7% from a year earlier to $10.63bn.
(Close): US stocks on the S&P 500 and Nasdaq have closed lower, with shares in Apple down nearly 4% after it reported another quarter of falling iPhone sales and revenues.