The boat is skippered by Daniel Smith and will sail into Londonderry on Wednesday evening as part of the city's LegenDerry Maritime Festival.
The 3,500 mile leg from New York to Derry was the 12th stage in the 16-series race.
The win puts the Derry crew in second place overall.
Crew members on the Derry-Londonderry-Doire yacht have said they are "excited to meet everyone in Derry".
A nine-day maritime festival, with a race village, summer promenade and sea-faring activities will begin in the city on Saturday.
Mayor of Derry City and Strabane District Council, Alderman Hilary McClintock, said the excitement is really building now ahead of the festival.
"The details of the full music line up have now been confirmed and there's much excitement about the week's events.
"The programme covers all genres and brings together an impressive mix of established names and top local artists.
"The atmosphere is going to be incredible."
Up to 100,000 people are expected in the city during the programme of events.
The Derry-Londonderry-Doire yacht has come second in the home leg of the Clipper Round the World yacht race.