It's up for the coveted video of the year prize, won in previous years by the likes of Beyonce for Formation, Taylor Swift for Bad Blood and Miley Cyrus for Wrecking Ball.
Here's a look at the five contenders.
Following on from MTV's Movie and TV Awards, the VMAs has scrapped its best female and best male video categories in favour of a new gender neutral award for artist of the year.
It's also introduced another new category - best fight against the system - to celebrate video that inspire viewers to stand up and fight injustice.
The nominees in that category are:
Among the British nominees include Ed Sheeran, who's up for three awards including artist of the year, best pop for Shape of You and best cinematography for Castle on the Hill.
Harry Styles's Sign of the Times is also up for two awards, while Coldplay, Calvin Harris and former One Directioner Zayn Malik are also nominated.
Fans can vote for their favourites across eight categories including video of the year, artist of the year and best collaboration on the MTV website.
You can see a full list of nominations here.
Winners will be announced at a ceremony in Los Angeles on 27 August.
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MTV has announced its nominations for this year's Video Music Awards (VMAs), with Kendrick Lamar scoring eight nods for the video to his track Humble.