The SNP won 56 of 59 Scottish seats with Labour, the Conservatives and Liberal Democrats retaining one each.
Labour lost a total of 40 constituencies to the Nationalists, 23 of them in Glasgow and the west.
The party's leader, Jim Murphy, has vowed to remain in charge, despite losing his own Renfrewshire East constituency to the SNP.
Mr Murphy has said he will stand for Holyrood in 2016.
He described the election as "a dreadful night" for Labour and said his party had been "overwhelmed".
In another high profile loss in the area, former Shadow Foreign Secretary Douglas Alexander lost Paisley and Renfrewshire South to a 20-year-old student.
The SNP's Mhairi Black, who is studying politics at Glasgow University, has become Britain's youngest MP since 1667.
She won with 23,548 votes - a majority of 5,684 and share of 50.9%.
Elsewhere in the Glasgow and west of Scotland area, Labour lost the following constituencies to the SNP: Airdrie and Shotts; Ayr, Carrick and Cumnock; Ayrshire Central; Ayrshire North and Arran; Coatbridge, Chryston and Bellshill; Cumbernauld, Kilsyth and Kirkintilloch East; Dunbartonshire West; East Kilbride, Strathaven and Lesmahagow; Glasgow Central; Glasgow East; Glasgow North; Glasgow North East; Glasgow North West; Glasgow South; Glasgow South West; Inverclyde; Kilmarnock and Loudoun; Lanark and Hamilton East; Motherwell and Wishaw; Paisley and Renfrewshire North; Renfrewshire East; Rutherglen and Hamilton West.
The Lib Dems failed to retain any seats in the patch, losing both Argyll and Bute and Dunbartonshire East to the SNP.
The majority of Labour seats in Scotland were lost in constituencies in Glasgow and the west of the country.