The incident, which also involved a car, left both carriageways completely blocked.
The road was closed between junction 6, A5 / A5114 (Llangefni), and junction 5, A4080 (Gwalchmai).
Earlier on Thursday, a motorcyclist was left with serious injuries following a crash on the A55 at Bodedern.
Part of the A55 on Anglesey has been reopened in both directions after a lorry overturned, shedding its load of steel and tools.