Burke, who had loan spells at Bradford and Hull KR, has made 19 appearances for Wigan this season.
The 23-year-old said: "This is an exciting opportunity for me to establish myself in a strong, competitive Super League side.
"I already know a few of the boys, that makes the transition easier, and I can't wait to take the field."
Widnes Vikings have signed Wigan Warriors prop Greg Burke on a two-and-a-half-year deal.