Goalkeeper Richard O'Donnell remains out with a hand injury.
Brighton centre-back Shane Duffy (metatarsal) is out for six weeks, with Uwe Hunemeier in line to replace him.
Left-backs Gaetan Bong (knee) and Sebastien Pocognoli (groin) are still sidelined, while centre-back Connor Goldson (heart) is out for the season.
On-loan striker Chuba Akpom will be assessed.
Despite having to deal with a host of defensive injuries, Albion boss Chris Hughton saw Liam Rosenior return to first-team action during Saturday's 3-0 defeat at Nottingham Forest following six months out with ankle trouble.
The reverse at the City Ground meant Brighton suffered back-to-back league defeats for the first time since September, and the Seagulls are six points ahead of third-placed Huddersfield in the table, having played a game more than the Terriers.
The Millers have won just one of their last 12 games in the Championship.
Rotherham captain Lee Frecklington (ankle) is likely to start after making his return from injury as a sub in the defeat by Aston Villa on Saturday.