Emergency services were called to Port Road in Dalbeattie at about 11:00.
Fire crews from Dalbeattie, Castle Douglas and Dumfries were sent to the scene and helped to remove the man from his Nissan Micra.
He was taken to Dumfries Infirmary for treatment while the van driver received a precautionary check-up.
Firefighters using hydraulic equipment have freed a man from his car after it was involved in a crash with a van in the south of Scotland.