The 39-year-old was walking on Forbes Place, near to its junction with Causeyside Street, when he was assaulted by a group of people.
He was taken by ambulance to the Royal Alexandra Hospital in Paisley where his condition was described as serious.
Police have appealed for witnesses to the incident, which took place at 20:25 on Saturday, to come forward.
Det Insp Tom Carty, of Paisley Police Office, said: "Inquiries are ongoing at this time to gather more information on the circumstances surrounding this incident and those responsible.
"At this time I would urge anyone who witnessed the attack take place, or who has any information that may assist the police investigation, to contact Paisley Police Office through 101."
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