Gwent Police said Thomas Lawrence died at the scene on Belmont Hill, Caerleon.
The teenager, from Pontypool, Torfaen, was taken to Newport's Royal Gwent Hospital where she remains in a critical condition.
There were no other vehicles involved in the crash, which happened at about 23:00 GMT on Wednesday, and officers are continuing to investigate.
The 21-year-old Newport man killed in a crash which also left a 16-year-old girl in hospital has been named.