The two-time series winners got their 2016 campaign off to a perfect start in Ramsey with victories in both the time trial and criterium.
Following their team trial victory, it was Chris Lawless from Wigan who won took the individual criterium.
Raleigh's Sebastian Mora finished second, with Dale Appleby (NFTO) third.
Local guest Owen Dudley, 17 and from the Isle of Man, finished an impressive sixth in near perfect cycling conditions in Ramsey.
The leading riders completed 33 laps of a one-mile (1.5km) closed road circuit.
With each team's top four riders counting in the time trial, JLT Condor edged out Madison Genesis by just two seconds, with Team Raleigh GAC a further second back.
The series opener was held as part of a new four-day festival of cycling on the island, which continues on Friday with a mass participation event and BMX GP.
The JLT Condor team claimed a double victory in the opening round of the Pearl Izumi Tour Series held as part of Cyclefest in the Isle of Man.