McDonald will join the Renegades during the English off-season, with their first game taking place on 22 December.
"I'm really looking forward for that period of time to come round, but first and foremost we've got a job to do here," he told BBC Radio Leicester.
"The focus is fully on Leicestershire and the end of the season."
Leicestershire elite performance director Andrew McDonald has agreed to coach Melbourne Renegades in the 2016-17 Big Bash League.