Fire crews were called to North Lane in the village of Oulton at about 02:30 BST to reports of a blaze.
A 40-year-old male was rescued from the building, which was heavily smoke-logged, a spokeswoman from West Yorkshire Fire and Rescue said.
Appliances from Rotherwell, Garforth and Stanks attended the incident. The cause is not yet known.
A man has been taken to hospital following a house fire near Rothwell in Leeds.