David Beckett said his beloved wife has passed away peacefully in a Manchester hospital.
"David and the programme's cast and crew are heartbroken and deeply saddened," said an ITV statement.
She appeared on the soap for more than 40 years and her co-stars have been sharing their memories of her life.
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Anne Kirkbride, who played Deirdre Barlow in Coronation Street, has died after "a short illness," her husband has confirmed.