18 October 2016 Last updated at 01:04 BST
Leagues are springing up and coaches and scouts travel across Africa looking for the next big star.
The BBC spent time with one young man hoping to make it to the MLB’s “Elite Africa” training camp taking place in Johannesburg later this year.
Video Journalist: Christian Parkinson
African players are hoping to hit the big time, as Major League Baseball (MLB) launches a talent hunt in the continent.