Nine fire engines were sent to Ladywood Road in Four Oaks, Sutton Coldfield, at about 23:20 GMT on Sunday.
West Midlands Fire Service said the derelict property was destroyed but there were no reports of any injuries.
The cause of the blaze was being investigated and a structural engineer has been called out to assess the damage.
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The road is the location of some of the most expensive properties in the West Midlands with houses selling for millions of pounds.
Two fire engines were deployed from Sutton Coldfield and Perry Barr and one appliance was sent from Erdington, Aldridge, Ward End, Sheldon and Ladywood.
Crews from one or two fire engines were damping down from dawn.
More than 40 firefighters have tackled a fire which destroyed a house in the West Midlands.