Officers were called to Park Road in the town, along with ambulance personnel, on Saturday morning.
They found that the man had died. Police said the death was being treated as "suspicious".
The dead man was said locally to be a bus driver in his 30s who is the father of young children.
A police spokesman said: "At 11:10 on Saturday, the police and emergency services responded to reports of a disturbance on Park Road, Girvan.
"A man, who is yet to be identified, was pronounced dead at the scene.
"A post-mortem examination will take place in due course to establish the cause of death.
"The death is being treated as suspicious. Inquiries are ongoing."
Police have launched an investigation following the death of a man after a disturbance in a street in Girvan, South Ayrshire.