Curtis Naughton, Glenn Stewart, Gregg McNally all come in for the Centurions, who are sixth in the table.
Catalans have only named an 18-man squad as they await the outcome of Tony Gigot's appeal against his ban for his behaviour towards a doping official.
Brayden Wiliame and Thibaud Margalet come into a squad that has two wins from seven games so far in 2017.
Leigh: Naughton, Brown, Crooks, Dawson, Ridyard, Hock, Higham, Stewart, Hansen, Pelissier, Tickle, Vea, McNally, Hampshire, Reynolds, Hood, Green, Hopkins, Burr.
Catalans: Inu, Wiliame, Walsh, Myler, Moa, Aiton, Casty, Anderson, Bousquet, Garcia, Baitieri, Duport, Simon, Burgess, Thornley, Albert, Da Costa, Margalet.
Leigh head coach Neil Jukes has made three changes to his squad after their home loss to Widnes last time out,.