Tipuric was injured in Wales' Six Nations win over Italy and is undergoing tests for concussion.
Ospreys have also confirmed the Scarlets game will be the first lock Alun Wyn Jones misses as he tries to overcome a heel injury.
Gloucester's Ross Moriarty scored two tries as Tipuric's replacement in Wales' rout of the Azzurri.
Tipuric had himself been given a start for Wales in the injury absence of Cardiff Blues' Wales captain Sam Warburton, who had been concussed in Wales' defeat by England at Twickenham the previous weekend.
Wales regular Jones was absent as Racing 92's Luke Charteris wore the his number five jersey alongside Wasps' Bradley Davies in the second-row.
More to follow.
Ospreys will be without Wales flanker Justin Tipuric when Scarlets visit them in the Pro12 on Saturday.