Midfielder James McCarthy (hamstring) and keeper Maarten Stekelenburg (dead leg) are still out, while new signing Ademola Lookman is cup-tied.
Leicester's Islam Slimani, Riyad Mahrez and Daniel Amartey are also missing because of Africa Cup of Nations duty.
Wilfred Ndidi is available to make his debut after his £15m move from Genk.
England striker Jamie Vardy, who has completed a three-match suspension for his sending-off at Stoke, and midfielder Danny Drinkwater (knee injury) could return as Foxes manager Claudio Ranieri shuffles his squad.
Everton manager Ronald Koeman:
"This competition is a title and if you ask every manager, they like to win titles.
"We know it is difficult, but we take it very seriously. We will go for it. We fight for everything."
Leicester City manager Claudio Ranieri:
"It is important the players who are involved now show their best to help the team go forward.
"This is my philosophy. I want to see everyone ready, everybody involved in our project. That is it."
Everton are without Senegal midfielder Idrissa Gueye for Saturday's FA Cup third-round tie against Leicester as he has left for the Africa Cup of Nations.