Four engines and a command support unit were sent out to the Technotots Nursery at the Wester Gourdie Industrial Estate at 06:30.
Crews wearing breathing apparatus used hose reels to control the fire. The blaze was contained within an hour, but crews remained on the scene to ventilate the building and damp down.
Police were called to assist, and advised motorists to avoid the area.
Firefighters tackled an early-morning fire at a nursery in Dundee.