The crash happened on Friday on the A4260 near Banbury, between Adderbury and Deddington.
The man's Ford Fiesta was in a collision with a Scania tipper lorry. Another car was also involved in the crash.
Thames Valley Police said the man was from Banbury and his next of kin had been informed.
The road was closed for several hours while officers investigated.
A 20-year-old man has been killed in a crash with a lorry on a road in Oxfordshire.