North Wales Police was called to reports of a disturbance in the Woodland Road West area of Colwyn Bay at 02:30 BST on Saturday.
A local man, 23, was taken to Ysbyty Glan Clwyd with serious injuries before being transferred to hospital in Stoke.
A Llandudno Junction man, 18, and a 27-year-old, from Mochdre, will appear before Llandudno magistrates on Monday.
The pair, who were both charged with attempted murder and possession of an offensive weapon in a public place, have been remanded in custody.
Police said the man in hospital is in a stable condition.
Det Insp Jackie Downes said: "We would like to thank those members of the community who have assisted us so far, and we continue to appeal to anybody who may have information in relation to this incident to contact us."
Two men have been charged with attempted murder after an incident in Conwy county.