The crash happened between Templepatrick and Sandyknowes on Monday night shortly before 20:40 GMT.
Police said the man was the driver of one of the cars involved in the crash.
Two other men were hurt in the incident but their injuries are not life threatening. The M2 was closed overnight between Templepatrick and Sandyknowes, but has now re-opened.
A man in his 30s has died in a multi-vehicle road crash on the M2 in County Antrim.