Police found 531 plants at the house in Rockfield Road, Anfield, at about 11:00 GMT on Tuesday.
Police said the farm had been set up in three different rooms and the electricity was also found to have been illegally bypassed.
Officers said the plants would have had an annual yield of about £2m. No arrests have been made.
A cannabis farm with a street value of £2m has been uncovered at a property in Liverpool following a police raid.