Police said she was hit at about 22:00 BST at the junction of Chester Road and Green Street in Stretford.
A 33-year-old man and a woman, 20, have been arrested on suspicion of causing death by dangerous driving.
A Greater Manchester Police spokesman said: "A woman in her 50s was sadly pronounced dead at the scene. Next of kin have been informed."
A woman in her 50s was killed when she was knocked down by a car in Greater Manchester on Friday night.