The crash happened in Ferryden, near Montrose, at about 13:45 on Monday.
The rider of the Honda bike died at the scene. The driver and passenger of a white Peugeot van were uninjured.
Police said Craig Road would be closed for some time while an investigation was carried out and drivers were urged to find alternative routes.
Officers urged witnesses to contact them using the 101 number.
The name of the dead man will not be released until relatives have been informed and a formal identification has been made.
A report will be sent to the procurator fiscal.
A motorcylist was killed when his bike was involved in a collision with a van in Angus.