A full road closure will be in place in Cardiff city centre from 12:30 GMT to 17:30 with the kickoff at 14:30 at the Principality Stadium.
Arriva Trains Wales passengers are advised a new queuing system will be in place at Cardiff Central for the match.
The council advised drivers to pre-book park and ride facilities.
Partial road closures will also be in place on Kingsway, Cowbridge Road East, Tudor Street, Plantagenet Street, Beauchamp Street, Saunders Road, Customhouse Street and Penarth Road.
Buses will be diverted from central city centre bus stops and will instead terminate at either Churchill Way for the east, Greyfriars Road for the north or Tudor Street for the west.
St Mary Street taxi rank will be shut from 14:30 and will re-open at 20:00.
Rugby fans are advised to be aware of travel restrictions and road closures due to Wales' Six Nations clash against Italy in Cardiff of Saturday.