Police were called to East Lancashire Road in Salford shortly after 18:10 BST to reports of a pedestrian being struck by a bus.
Officers found a woman believed to be in her 70s with very serious injuries. She was taken to hospital where she died at about 19:40.
Police, who are appealing for witnesses, said officers were providing the woman's family with support.
A woman has died after being hit by a bus in Greater Manchester.