Brand, who has appeared on television shows including QI and Have I Got News For You, had a previous career as a psychiatric nurse.
She said she was "delighted" to be given the doctorate from the university.
The ceremony will take place at Symphony Hall on 12 January.
Brand said: "I do thank the university for this recognition. Birmingham is one of my favourite places to perform because the audiences are always so friendly and they laugh a lot."
Updates on this story and more from Birmingham
Comedian Jo Brand is to receive an honorary doctorate from Birmingham City University, for her work in raising awareness about mental health.