Mitch Hancox gave the hosts an early advantage when he shot past Elliot Justham from long range.
Luke Guttridge, however, deservedly levelled matters for Dagenham five minutes before the break when he curled a free-kick around the wall and past a despairing Scott Flinders.
In the second half, Macclesfield defender Neill Byrne was red-carded when he pulled down Paul Benson in the box and Corey Whitely put John Still's men 2-1 up from the spot.
Substitute Jordan Maguire-Drew turned the away side's advantage into a commanding cushion with two late goals, the second a beautiful dink over Flinders.
Report supplied by the Press Association.
Match ends, Macclesfield Town 1, Dagenham and Redbridge 4.
Second Half ends, Macclesfield Town 1, Dagenham and Redbridge 4.
Goal!  Macclesfield Town 1, Dagenham and Redbridge 4. Jordan Maguire-Drew (Dagenham and Redbridge).
Substitution, Dagenham and Redbridge. Frankie Raymond replaces Andre Boucaud.
Substitution, Macclesfield Town. Jack Mackreth replaces Rhys Browne.
Goal!  Macclesfield Town 1, Dagenham and Redbridge 3. Jordan Maguire-Drew (Dagenham and Redbridge).
Substitution, Dagenham and Redbridge. Luke Howell replaces Corey Whitely.
Substitution, Macclesfield Town. Danny Whitehead replaces Luke Summerfield.
Substitution, Macclesfield Town. George Pilkington replaces John McCombe.
Goal!  Macclesfield Town 1, Dagenham and Redbridge 2. Corey Whitely (Dagenham and Redbridge) converts the penalty with a.
Neill Byrne (Macclesfield Town) is shown the red card.
Substitution, Dagenham and Redbridge. Jordan Maguire-Drew replaces Elliott Romain.
John McCombe (Macclesfield Town) is shown the yellow card.
Second Half begins Macclesfield Town 1, Dagenham and Redbridge 1.
First Half ends, Macclesfield Town 1, Dagenham and Redbridge 1.
Goal!  Macclesfield Town 1, Dagenham and Redbridge 1. Luke Guttridge (Dagenham and Redbridge).
Goal!  Macclesfield Town 1, Dagenham and Redbridge 0. Mitch Hancox (Macclesfield Town).
First Half begins.
Lineups are announced and players are warming up.
Dagenham bolstered their play-off prospects in the National League with an emphatic comeback win at 10-man Macclesfield.