The two-vehicle collision happened on the Derrygonnelly Road at about 14:00 BST on Saturday.
Three other people were injured in the crash, one who was in the same car as the man who died and two who were in the other vehicle.
The name of the man who was killed has not yet been released. He died on Saturday, but details were not released until Sunday.
Police have appealed for anyone who witnessed the crash to get in contact with them.
A man has been killed in a car crash in Enniskillen.