The former Crewe player, who was out of contract with Argyle after making 93 appearances, has agreed a one-year deal with the option of a further 12 months.
The 25-year-old told Blackpool's website: "I can't wait to get started now. I hope to bring a lot of energy and determination to the team.
"I love to win so let's make that happen. Hopefully we can do something this season."
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League Two side Blackpool have signed Plymouth right-back Kelvin Mellor.