Police discovered the 23-year-old after they were called to a property in Brightmeadow Close, Breightmet, Bolton, at about 04:15 GMT.
The victim was taken to hospital, where he later died.
Greater Manchester Police is yet to make any arrests and the force is appealing for anyone with information to come forward.
Ch Insp Carol Martin said: "First and foremost our thoughts go out to the family and friends of this young man.
"We are currently trying to piece together what happened before police arrived at the scene, and we will be doing everything we can to find the person or persons responsible.
"I would like to appeal to anyone who may have witnessed the disturbance or seen anything suspicious before or after police arrived to get in touch."
A murder investigation is under way after a man was stabbed to death in Greater Manchester.