The 28-year-old man is in Hull Royal Infirmary after a violent incident at a house in Hainton Avenue, Grimsby on Friday, said Humberside Police.
The two local men, aged 32 and 24, are currently being questioned in police custody.
A cordon was erected on Hainton Avenue while a forensic examination was carried out.
A man has been wounded and hospitalised and two other men arrested on suspicion of assault.