The suspects, both 16, are accused of the murder of Duran Junior Kaijama, who died following an incident in Dagenham on 12 November.
They are also charged with attempted murder in relation to another 16-year-old who was taken to hospital with stab injuries.
Duran, found with a stab wound in Wyhill Walk, later died in hospital.
Police said the charged teenagers will both appear at Barkingside Magistrates' Court on Saturday.
Another 16-year-old boy appeared at Uxbridge Magistrates' Court on Friday, also charged with Duran's murder and attempted murder.
He was remanded in custody to appear at the Old Bailey at a date to be set.
Two teenagers have been charged with murder following the stabbing of a 17-year-old boy in east London.