what season does izzie die on grey's anatomy
Izzie Stevens Izzie supports Alex when he discovers his new girlfriend has psychiatric problems, and convinces him to have her committed. She is also handed primary responsibility for the clinic, as Bailey cuts back on her responsibilities.[18] Izzie and Alex go on to rekindle their relationship, though Izzie is concerned when she begins hallucinating Denny.[19] She discovers she has metastatic melanoma (Stage IV) which has spread to her liver, skin, and brain, causing the hallucinations. Her survival chances are estimated at only 5%.[20] She is admitted to Seattle Grace as a patient, and Derek Shepherd (Patrick Dempsey) successfully removes a tumor from her brain.[21] Izzie spends her time in the hospital planning Meredith and Derek's wedding, but when her condition worsens and Derek discovers a second brain tumor, they give the ceremony to Izzie and Alex, who marry in front of all their friends.[22] The procedure to remove the second tumor from Izzie's brain causes her to lose her short-term memory, and although she soon regains it, she flatlines moments later. The fifth season ends with her friends ignoring her DNR order and attempting to resuscitate her, transposed with images of Izzie in an elevator encountering George, who has been in an accident and is also currently flatlining.[23] Though George dies, Izzie is resuscitated and recovers enough to return to work.[24]
Preston Burke While mentioned in passing throughout later seasons, Burke officially returns in the tenth season in order to conclude Cristina Yang's departure from the series.[3]
Derek Shepherd In January 2014, Dempsey signed a two-year contract to remain on Grey's Anatomy (then in its tenth season) that would ensure his presence for potential 11th and 12th seasons.[20] However, in April 2015, Dempsey's character was killed off[21] while his contract was not over yet. Dempsey explained: "it just sort of evolved. Itâ€™s just kind of happened. It really was something that was kind of surprising that unfolded, and it just naturally came to be. Which was pretty good. I like the way it has all played out."[22] In August 2015, Rhimes commented:
Dan Humphrey Five years later, Dan and Serena get married, surrounded by their closest friends and family.