Researchers have found that when very overweight people, who tend to have relatively low metabolic rates, lose weight primarily through dieting, their metabolisms generally remain unchanged  They will thus burn significantly fewer calories at the new weight than do people whose weight is normally at that level
Researchers have not yet determined whether the metabolic rates of formerly very overweight individuals can be accelerated by means of chemical agents.
 Such newly thin persons will, ttherefore, ultimately regain weight until their body size again matches their metabolic rate