Human influenza virus mainly acts on the receptor subtype alpha 2.6 in the nose and throat, while H5N1 virus usually affects the receptor subtype alpha 2.3 in the lower respiratory tract. This difference determines that avian influenza virus is not easy to spread through salivary droplets. However, the latest gene sequencing results show that Turkish avian influenza virus is more likely to bind to receptor subtype alpha 2.6.
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Increased infectivity of avian influenza virus