many studies on unruptured aneurysms have reported a prevalence of approximately 3.6 to 6% and a bleeding rate of approximately 2.3 to 0.3%/year.1)18 ) for the giant aneurysm (  25 mm ) , a rupture rate of 6% has been reported for one year since the first diagnosis , and based on the natural history , it was considered bad due to high lethality.1)15)20 ) however , with technological developments in the fields of surgery and anesthetics since the 1970s-1980s , the mortality and morbidity associated with the operation have shown a rapid decrease .
in addition , advances in diagnostic technology have made it possible to find and treat an unruptured aneurysm that has already been diagnosed prior to the rupture.8 - 10 ) accordingly , most studies on unruptured aneurysms have reported symptoms that appear prior to the rupture of an aneurysm , and have discussed correct diagnostic procedures , various treatments and results .
the last path of the natural history of an unruptured aneurysm concerns death or disability caused by the rupture . however , few studies on unruptured aneurysms that have disappeared by spontaneous cure have been reported . due to medical ethics , conduct of such clinical studies
we report on a large right middle cerebral artery ( mca ) aneurysm , which induced subarachnoid hemorrhage ( sah ) after rupture and showed spontaneous occlusion after a wrapping operation . the characteristics and causes of the aneurysm and possible spontaneous cure
no abnormal findings were observed on the first neurologic examination , while other medical examinations also showed normal findings .
findings on brain computed tomography ( ct ) examination showed a slightly high - density intra axial mass lesion measuring approximately 2.5 cm lateral sides on the right sylvian fissure .
it showed no edema around the mass , iso - density and strong enhancement without calcification inside ( fig .
according to findings on a three - dimensional ct angiogram ( 3-d cta ) examination , the mass was diagnosed as a saccular aneurysm in the right mca bifurcation ( fig .
t2 weighted images from a brain magnetic resonance image ( mri ) examination showed a high signal in the aneurysm and a heterogeneous peripheral low signal . at the back of the aneurysm sac ,
a t1 weighted image showed a low signal in a part close to the circle of willis and an iso signal far from it . like the ct image , it showed a slightly low signal with dense contrast enhancement and difference in filling in the aneurysm sac ( fig .
in addition , sah was not found on the ct examination ; however , a small amount of sah was noted around the aneurysm and along the sylvian fissure . in the right internal carotid artery ( ica ) angiogram ( three - dimension subtraction image ) posterior to anterior view
, an aneurysm measuring 21.6  20.9 mm in the right mca bifurcation was observed in a lateral direction .
it formed a broad neck along an inferior branch of m2 and several perforating branches were observed around the neck ( fig .
it is specific in the angiogram that the filling of the aneurysm in the early arterial phage was not partially performed .
filling of the aneurysm in the later arterial phage was completed , without excretion up to the capillary phage .
direct clipping in the operation field was difficult ; therefore , the operation was completed after wrapping the ruptured portion using surgical glue .
the patient was discharged from the hospital without complications . according to findings on the mri examination performed approximately months after discharge , a target sign that appeared as a high signal , and a low signal in a slightly inner portion and a high signal again in a central portion ,
an examination after 19 months showed that the size of the aneurysm had decreased considerably ( fig .
5b ) . finally , according to findings on the angiogram and mri examination ( which were performed after three years and eight months ) , there was no trace of the mass in the sylvian fissure due to the considerable reduction in the size of the aneurysm and almost everything in the m2 branch was intact ( fig .
occlusion of an aneurysm due to spontaneous thrombosis was first reported in 1955.2 ) the risk of a ruptured aneurysm became known in the mid 1970s , however , due to high mortality and morbidity associated with the operation , administration of an active treatment for ruptured aneurysm was difficult .
they have been widely spread by yasargil since the mid-1970s , which led to an increase in the success rate of operation and a decrease in complications from anesthesia .
it also led to a rapid decrease in mortality and morbidity from the operation.21 ) however , according to the development of diagnostic technologies , including ct , mri , and other methods , the number of cases of diagnosed unruptured aneurysm has shown a continuous increase , and treatment of unruptured aneurysm has recently become a controversial issue .
in addition , questions arose regarding the bleeding rate in the natural history of an unruptured aneurysm , or whether to treat the aneurysm or monitor its progress by comparing the bleeding rate , and mortality and morbidity of the operation .
likewise , a randomized controlled study is the most ideal approach to understanding the natural history of a ruptured aneurysm .
many papers have reported a high bleeding rate in the natural history of an unruptured giant aneurysm , while several case reports on spontaneously cured aneurysms have been published .
loevnet et al.12 ) reported a large basilar artery aneurysm found nine months after a seven - year - old boy received a trauma , which showed complete disappearance after six years .
morn et al.14 ) reported on a traumatic posterior cerebral artery aneurysm of a six - year - old boy , which disappeared completely after five years .
other cases of spontaneous occlusion of a traumatic aneurysm have been reported , insisting that less than 15% of traumatic aneurysms were cured spontaneously.15 ) krapt et al.11 ) suggested that a congenital , unruptured giant aneurysm in a nine - month - old female infant was completely occluded and absorbed , based on three - year examination .
there have also been papers on infants who could not undergo an operation or spontaneous occlusion of a traumatic aneurysm , however , few reports on the natural history of an un - ruptured aneurysm have been published .
vasconcellos et al.3 ) proposed that 25% ( five cases ) of 20 cases showed courses of spontaneous occlusion during observation of giant carotid cavernous aneurysms of the internal carotid artery with a relatively low risk of bleeding .
the possibility of spontaneous occlusion was relatively high in cases of improvement of initial symptoms , such as retrobulbar pain or migraine during courses of carotid cavernous giant aneurysms .
a factor to analogize spontaneous occlusion of an unruptured aneurysm is the volume - to - orifice ratio.20)29 ) through analysis of the results for the ratio of the size ( mm ) of the aneurysm neck to the aneurysm volume ( mm ) from studies on 21 aneurysms , a value greater than 25 mm indicates the potential for thrombosis , and a value greater than 28 mm indicates a strong possibility of thrombosis .
thus , it is assumed that as the volume - to - orifice ratio grows larger , thrombosis appears more frequently by inducement of red blood cell aggregation thrombosis due to blood stasis in the aneurysm .
accordingly , the pathophysiology of thrombosis is not clear , however , it has received the most support .
the volume - to - orifice ratio calculated in our case was 28 mm , and the results of angiography showed partial dye filling in the aneurysm in the early arterial phage , maximum filling in the late arterial phage , and slow filling delayed excretion in the capillary phage .
the other study insisted on the possibility that thrombosis could cause intermittent vasospasm or dehydration caused by non - ionic contrast media while reporting cases of aneurysm that has caused thrombosis after angiography .
however , it was impossible to demonstrate the correct mechanism.7 ) partial thrombosis of a giant aneurysm from 48 to 76% has been reported , however , sources demonstrating complete thrombosis are scarce.6 ) through observation reports on 22 cases of giant intracranial aneurysms , whittle and et al.19 ) overthrew the conventional assumption that partial thrombosis in an aneurysm can reduce hemorrhage risk , by demonstrating that there was no difference in incidence of sah in 12 cases of thrombosis and non - thrombosis .
they also insisted that mortality generated after sah , and mortality and morbidity before and after surgery did not differ .
as a result , they reported that partial thrombosis of the aneurysm did not reduce the risk of sah and only aneurysms with total thrombosis reducing the risk of sah .
they also argued that partial thrombosis did not influence procedures or methods for treatment of giant aneurysms . due to the dynamic and reversible courses of thrombosis of aneurysms , observation of a course over a long period of time is necessary .
in addition , its generation and resorption are performed repeatedly , and complications such as thromboembolic infarct can occur.13 ) whittle et al . insisted that wrapping of a ruptured aneurysm had an effect on small aneurysms , but that wide - based , large , or giant types of mca aneurysms are associated with a high risk of rebleeding and fatal outcomes .
wrapping was generally known as an inadequate method of treating an aneurysm.5)16 ) accordingly , it is impossible for wrapping to stop rebleeding of the aneurysm.5)17 ) deshmukh et al.4 ) reported that according to angiographic follow - up studies on 34 patients who underwent wrapping of an aneurysm for an average of 3.4 years , there was no change in the size and shape of the aneurysm . despite reports on rupture caused by wrapping or a change in size
, there was no basis for occlusion of the aneurysm after wrapping , as manifested in our case .
the authors report on a case of spontaneous occlusion and absorption of a saccular aneurysm of mca bifurcation .
it was assumed that in the pathophysiology of spontaneous occlusion of an aneurysm , sluggish flow in the aneurysm may be the cause and the volume - to - orifice ratio of the angiography , slow filling , and delayed excretion through prediction of slow flow may manifest . in cases of inoperable aneurysm ,
however , long - term observation is more critical for an aneurysm that does not involve a stationary lesion and one that has dynamic courses .
conduct of further studies on the characteristics and types of aneurysms that will undergo spontaneous occlusion is needed .
 there are few observation papers regarding the natural history of an aneurysm . 
 we report on a case of a completely occluded middle cerebral artery ( mca ) aneurysm . 
 a 47-year - old female patient presented with a headache and was diagnosed with rupture of a right mca aneurysm . due to a high risk of direct neck clipping 
 , she received conservative treatment after craniotomy and wrapping of her aneurysm . 
 the patient 's condition showed improvement , with complete occlusion of the aneurysm and considerable reduction of the aneurysm in size after approximately three years . 
 this is a rare case of an aneurysm of mca that showed spontaneous resolution . finally , on the angiogram 
 , characteristics of an aneurysm to occlude spontaneously will be presumed based on literature reviews . 