premature ovarian aging ( poa ) is defined by elevated age - specific basal follicle stimulating hormone ( fsh ) cut - off levels with menstruation .
the age - specific cut - off level under the age of 33 years ( our patient 's age ) is 7.0 miu / ml .
there are four main causes for pof , namely , idiopathic , genetic , autoimmune , and viral causes .
can we extend causes of pof to poa ? if causes are similar and we evaluate women for poa , can we delay the process of pof ? with these thoughts , we evaluated this patient and we are reporting the case . a study by gleicher et al . titled
 concluded that presumed underlying etiologies of poa follow a similar distribution pattern as reported for pof .
they proved the hypotheses that poa is a precursor stage of pof and hence requires similar evaluation .
she had an elevated basal fsh level of 28 miu / ml 3 months back .
her height was 1.68 m and she weighed 50 kg with a body mass index of 19 kg / m .
a transvaginal ultrasound scan showed a normal - sized uterus but ovaries were not visualized .
the repeat basal fsh level ( after 6 weeks ) was 27 miu / ml .
since the basal fsh level was above the age - specific cut - off level ( 7 miu / ml for 33 years of age ) , diagnosis of poa was considered and karyotype was requested .
jacobs et al . described the first association of triple x syndrome with pof in 1959 .
a total of 21 cases of pof with triple x syndrome have been reported in the literature , but to the best of our knowledge , this is the first case report of poa with triple x syndrome .
genetic causes comprised approximately 16% of the total in the study conducted by gleicher et al . both autosomes and x chromosomal involvement
they are turner mosaicism , partial x chromosome deletion , x chromosome mosaicism , x chromosome inactivation , and fmr 1 ( fragile site mental retardation x gene ) .
x chromosome partial deletions are more common , while balanced x chromosome to autosome translocation of xq13q26 is rare , but documented .
autosomes involved are at the following gene loci : 3q , 13q , 14q , 17q , 15q , and 11p .
genetic defects are proposed to cause poa and pof by increasing atresia of ovarian follicles due to apoptosis or failure of follicle maturation and thus decreasing the pool of primordial follicles .
triple x syndrome women also suffer from psychiatric disorders like schizophrenia , eeg abnormalities , scoliosis , and genitourinary malformations .
poa with triple x syndrome and primary infertility is treated with ovulation induction by gonadotrophins , because of elevated basal fsh values .
prenatal diagnosis for pregnant women with triple x syndrome is definitely required as there will be 25% chance of x chromosomal abnormalities in the offspring .
hence , we conclude that it is essential to consider karyotyping for all cases of poa , and age - specific basal fsh values will help us detect cases of poa .
 genetic aberrations comprise one - third of women with premature ovarian aging ( poa ) . 
 x chromosome abnormalities are seen in these women . 
 we report a case of a 29-year - old lady with primary infertility and poa . 
 she was phenotypically normal and her basal follicle stimulating hormone level was above the age - specific cut - off . 
 karyotype was triple x syndrome . 