the dietary magnesium intake tends to be lower than that recommended worldwide even in western countries .
several factors have been identified to be trigger for lowering magnesium intake including the waterborne magnesium factor , the loss of magnesium during food refining , and the magnesium content of vegetarian diets , as well as various metabolic situations such as hypertension , pregnancy , osteoporosis , drug therapy , alcoholism , stress , and even cardiac trauma .
magnesium is the most abundant intracellular divalent cation that is important for physiological processes including neuromuscular function and maintenance of cardiovascular tone .  
the importance of magnesium intake in relation to cardiovascular diseases has been increasingly described , so that its intake can be inversely related to the risk of hypertension and type 2 diabetes mellitus   and may improve serum lipid profiles .
recent surveys in sweden [ 3 , 4 ] have indicated that vegetarian diets provide a more adequate intake of magnesium , as illustrated in table 4 . note that the magnesium intake of men and women on vegetarian diets was considerably greater than the rda requirement ; this was attributed to the high intake of vegetables and whole - grain cereals by these individuals .
recent studies have shown that some components of the mediterranean diet such as vegetables , legumes , and nuts are rich sources of magnesium ; therefore , it seems that the high adherence to the mediterranean diet is associated with high consumption of magnesium .
although the main dietary regimen of iranian population is mediterranean diet components especially the major sources of magnesium , the rate of coronary artery disease ( cad ) risk factors among this population has been considerably high . therefore , in the present study , we tried to determine effect of mediterranean dietary approach on laboratory parameters related to cad risk factors with the focus on serum magnesium concentration among iranian patients with cad .
baseline characteristics and clinical data of 102 consecutive patients with the diagnosis of cad and candidates for isolated coronary artery bypass surgery were entered into the study .
studied data were collected by the review of clinical recorded files in the day of admission . in this study ,
cad was considered significant if there was a 75% or greater stenosis in the cross - sectional diameter and 50% or greater stenosis in the luminal view .  
blood samples were drawn from the corresponding peripheral vein into vacutainer tubes after 1214  h of overnight fasting and before operation .
plasma glucose concentrations were assessed by means of a glucose hexokinase method ( pars azmoon kits accredited by bioactiva diagnostica , germany ) . serum total cholesterol , hdl cholesterol , and triglycerides were measured via enzymatic techniques ( pars azmoon kits accredited by bioactivadiagnostica , germany ) .
the friedewald formula was used to calculate low density lipoprotein ( ldl ) cholesterol , except when the triglyceride level was >
blood pressure was calculated as the mean of two measurements , performed in the sitting position after 5 minutes of rest , using a random - zero sphygmomanometer ( hawksley - gelman , lancing , sussex , uk ) .
c - reactive protein ( crp ) level was measured by immunoturbidimetry ( pars azmun , iran ) , and lipoprotein(a ) was measured using tint eliza ( biopool , usa ) .
creatinine was measured with jaffe reaction ( parsazmon kit , tehran , iran ) using an autoanalyzer ( hitachi , tokyo , japan ) .
studied patients were also interviewed on admission to surgical ward and before operation to report the consumption of food items listed as the number of times per day , per month , or per year during the previous year .
we assessed nutritional status by a validated food frequency questionnaire ( ffq ) , previously validated in iran   and a 24-hour dietary recall questionnaire to record the types , amounts , and frequencies of foods consumed .
sum of the consumption of each of several food items was used to determine the overall consumption of the food group to which each item belonged [ 9 , 10 ] .
the diet score was calculated on the basis of mediterranean diet quality index ( med - dqi ) that the construction of the score for this index ( table 1 ) .
the index assigns a score of 0 , 1 , or 2 according to the daily intake of each of the seven components and then final score was reported as a summation of all nutrient scores ranged between 0 and 14 .
we divided studied patients into two groups according to the final score : the groups with final score lower than 5 ( n = 35 ) and those who had final score between 5 and 10 ( n = 67 ) .
we compared categorized variables between the two above groups using chi - square test or fisher 's exact test if required .
multivariate linear regression analysis was used to investigate the potential confounding effects of patients ' characteristics and clinical data on the association between serum magnesium concentration and mediterranean regimen score .
all the statistical analyses were performed using spss version 13.0 ( spss inc . , chicago , il , usa ) .
studied patients had the mean age of 58.8 year ( ranged between 38 and 78 years ) and 40.2% of them were male .
hyperlipidemia and hypertension were observed in 75.5% and 56.9% of patients , respectively , and 51.0% of them were diabetics .
half of the studied patients had moderate functional class , but three coronary arteries were involved in the majority of them ( table 2 ) .
comparison of the concentrations of serum laboratory parameters between the two groups with lower mediterranean dietary score and group with higher dietary score showed no significant differences between the concentration of albumin , last fasting blood sugar , last creatinine , and lipid profiles ( table 3 ) ; however , serum magnesium concentration in the group with dietary score between 5 and 10 was lower than that in group with higher score ( p = 0.026 ) .
linear multivariate regression analysis also showed that the lower mediterranean dietary score was a predictor for serum magnesium concentration after adjusting for confounders ( table 4 ) .
recent studies could confirm the cardioprotective role of intravenous magnesium for prevention of cardiac arrhythmia , pump dysfunction , and death in patients with cad , especially in the immediate postinfarction period [ 12 , 13 ] .
magnesium can inhibit the influx of calcium in vascular smooth muscle cells and therefore inhibit arrhythmic recurrence and the production of il-6 and mmp-1 after reperfusion and prevent the increase of myocardial lesions caused by calcium overload on myocytes .
however , effect of dietary intake of this mineral on control and inhibition of cad risk factors has been questioned .
some researchers have been hypnotized that the low intake of magnesium may be related to the least degree of cardiovascular disease [ 15 , 16 ] .
some others could show that the dietary magnesium intake can be inversely associated with fasting serum insulin , plasma high density lipoprotein - cholesterol , and systolic and diastolic blood pressure . in the present study
, we showed the potential effect of mediterranean dietary regimen on increasing of serum magnesium concentration that can mainly lead to the favorite control and prevention of cad risk factors .
we have shown that not only intravenous magnesium administration can be related to the lower risk of poor outcome in patients with cad , but also these effects can be obtained by dietary intake of this mineral via mediterranean dietary regimen . in a similar study by schrder
, it was found that the high consumption of vegetables , fruits , legumes , nuts , fish , cereals , and olive oil as main components of mediterranean regimen led to high absorption of magnesiumin obesity and type 2 diabetes . also , singh showed that the increased intake of dietary magnesium in association with the general effects of a nutritious diet can offer protection against cardiovascular deaths among high - risk individuals predisposed to cad .
furthermore , in another study , it was observed that the intake of dietary magnesium was associated with a reduced risk of cad ; however , associations between dietary magnesium and coronary events occurring after fifteen years of follow - up were modest .
it seems that the mediterranean dietary regimen and its components as rich pools of magnesiummight optimize micronutrient status in main body organs especially cardiovascular system .   in the present study
, it was also found that the patients ' baseline characteristics and even severity of cad had no relationship with serum magnesium concentration in multivariate analysis .
similarly , in a study by mataix et al . , the risk of hypomagnesemia was not associated with any of the other factors that were investigated such as gender , educational level , obesity , smoking habits , alcohol consumption , and physical exercise .
however , some studies showed that the magnesium intake could decrease in advanced age and in men for each of the different race or ethnic groups .
it seems that the serum magnesium changes are mainly dependant on nutritional habit , metabolicprocesses , inflammatory biomarkers , and other related - potential mechanisms that should be investigated in future studies .   in conclusion , taking mediterranean dietary regimen can be associated with increased level of serum magnesium concentration , and thus this regimen can be cardioprotective because of its effects on serum magnesium .
 
 background . 
 recent studies confirmed cardioprotective role of intravenous magnesium for the prevention of cardiac events , but effect of dietary intake of this mineral via recommended dietary regimens on control and inhibition of coronary artery disease ( cad ) risk factors has been questioned . 
 the aim of the present study was to determine effect of mediterranean dietary approach on serum magnesium concentration among iranian patients with cad . 
 method . 
 baseline characteristics and clinical data of 102 consecutive patients with the diagnosis of cad and candidates for isolated coronary artery bypass surgery were entered into the study . 
 laboratory parameters especially serum magnesium concentration were measured after 1214  h of overnight fasting and before operation . 
 nutritional status was assessed by food frequency questionnaire and the diet score was calculated on the basis of mediterranean diet quality index ( med - dqi ) . 
 results . 
 no significant differences were found in the concentrations of albumin , last fasting blood sugar , last creatinine , and lipid profiles between the groups with mediterranean dietary score < 5 and the group with higher dietary score ; however , serum magnesium concentration in the first group was higher than that in the group with higher dietary score . 
 linear multivariate regression analysis showed that the lower mediterranean dietary score was a predictor for serum magnesium concentration after adjusting for confounders . 
 conclusion . 
 taking mediterranean dietary regimen can be associated with increased level of serum magnesium concentration , and thus this regimen can be cardioprotective because of its effects on serum magnesium . 