A common infectious disease, otitis media (OM) has a low rate of early diagnosis, which significantly increases the difficulty of treating the disease and the likelihood of serious complications developing including hearing loss, speech impairment, and even intracranial infection. Several areas of healthcare have shown great promise in the application of artificial intelligence (AI) systems, such as the accurate detection of diseases, the automated interpretation of images, and the prediction of patient outcomes. Several articles have reported some machine learning (ML) algorithms such as ResNet, InceptionV3 and Unet, were applied to the diagnosis of OM successfully. The use of these techniques in the OM is still in its infancy, but their potential is enormous. We present in this review important concepts related to ML and AI, describe how these technologies are currently being applied to diagnosing, treating, and managing OM, and discuss the challenges associated with developing AI-assisted OM technologies in the future.