Fungal keratitis is a severe corneal infection, and the causative fungi include various rare fungal species. Fungal keratitis caused byTalaromycesspecies has yet to be reported, and there is no information about this fungus as a cause of keratitis. A 77-year-old man developed fungal keratitis while waiting for a donor cornea due to bullous keratopathy in his left eye. Fungal culture of a corneal scraping grew filamentous fungi, which were morphologically identified asPaecilomycesspecies. The corneal infection did not improve after topical administration of 1% voriconazole, and ribosomal DNA sequencing definitively verified the fungus to beTalaromyces coalescens. The lesion gradually improved after switching to topical 5% natamycin. Antifungal susceptibility tests determined the high minimum inhibitory concentrations of voriconazole to be > 8 μg/mL. This is the first report ofTalaromycesfungal keratitis. Clinicians, especially those in ophthalmology, need to be aware of this rare fungus.