Key PointsQuestionWhat is the prevalence of urinary tract infection, bacteremia, and bacterial meningitis in febrile infants with SARS-CoV-2 aged 8 to 60 days?FindingsIn this cross-sectional study of 14 402 febrile infants aged 8 to 60 days, the prevalence of urinary tract infection, bacteremia, and bacterial meningitis was low for infants who tested positive for SARS-CoV-2, particularly infants aged 29 days or older and those with normal inflammatory markers.MeaningThis study’s results suggest that the low prevalence of concomitant bacterial infections can potentially inform the evaluation and management of certain febrile infants with SARS-CoV-2.