A hypervirulentKlebsiella pneumoniaeSL218 (ST23-KL57), phylogenetically distinct from the classical hypervirulent SL23 (ST23-KL1) lineage, was transmitted between hospitalised patients in Denmark in 2021. The isolate carried a hybrid resistance and virulence plasmid containingblaNDM-1and a plasmid containingblaOXA-48(pOXA-48); the latter plasmid was horizontally transferred within-patient toSerratia marcescens. The convergence of drug resistance and virulence factors in single plasmids and in different lineages ofK. pneumoniaeis concerning and requires surveillance.