PurposeTo identify the survival and prognostic factors for cardiac amyloidosis (CA) in Chinese patients.MethodsThis was a prospective cohort study of 72 patients diagnosed with CA and admitted to the PLA General Hospital between November 2017 and April 2021. Demographic, clinical, laboratory, electrocardiographic, conventional ultrasound, endocardial LS during LV systole (LV ENDO LSsys), and myocardial strain data were recorded. Survival was assessed. All-cause mortality was the endpoint. Follow-up was censored on September 30, 2021.ResultsThe mean follow-up was 17.1 ± 12.9 months. Among the 72 patients, 39 died, 23 survived, and 10 were lost to follow-up. Mean survival for all patients was 24.7 ± 2.2 months. Mean survival was 32.7 ± 2.4 months among patients with NYHA class II, 26.6 ± 3.4 months for NYHA class III, and 5.8 ± 1.1 months for NYHA class IV. The multivariate Cox proportional hazard regression model showed that NYHA class (HR = 3.42, 95% CI: 1.36–8.65,P= 0.002), log-proBNP level (HR = 1.40, 95% CI: 1.17–5.83,P= 0.03), and ENDO LSsys of the LV basal level (HR = 1.25, 95% CI: 1.05–1.95,P= 0.004) were independent prognostic factors for CA.ConclusionNYHA class, proBNP level, and ENDO LSsys of the LV basal level were independently associated with the survival of patients with CA.