A tomographic tactile sensor based on the contact resistance of conductors is a high sensitive pressure distribution imaging method and has advantages on the flexibility and scalability of device. While the addition of internal electrodes improves the sensor’s spatial resolution, there still remain variations in resolution that depend on the contact position. In this study, we propose an optimization algorithm for electrode positions that improves entire spatial resolution by compensating for local variations in spatial resolution. Simulation results for sensors with 16 or 64 electrodes show that the proposed algorithm improves performance to 0.81 times and 0.93 times in the worst spatial resolution region of the detection area compared to equally spaced grid electrodes. The proposed methods enable tomographic tactile sensors to detect contact pressure distribution more accurately than the conventional methods, providing high-performance tactile sensing for many applications.