BackgroundLifestyle habits are vital components of the culture of mental health treatment settings. We examined the bridge connection between depressive and anxiety symptoms and lifestyles from a network perspective using a population-based study.MethodsFace-to-face interviews were conducted with a provincially representative sample of 13,768 inhabitants from the Guangdong Sleep and Psychosomatic Health Survey based on standardized evaluation techniques. We identified the central symptoms by expected influence. The interconnection between depression and anxiety symptoms, as well as the bridge connectivity linking depression–anxiety symptoms and lifestyle factors, were assessed using the bridge centrality index. Network stability and sensibility analyses were performed using a case-dropping bootstrap procedure.ResultsThe core symptom that exhibited the highest expected influence wasfatigue or little energy, followed byuncontrollable worry, trouble relaxing, andsad moodin the depression-anxiety symptoms network, whileguiltwas the most interconnected symptom and had the highest bridge strength. Surrounding nodes of each node explained an average variance of 57.63%. Additionally,suicidal thoughtswere recognized as collective bridging symptoms connecting lifestyle variables in the network integrating depression-anxiety symptoms with lifestyle factors. Current tobacco and alcohol consumption were positively associated withsuicidal thoughtsandirritability. Habitual diet rhythm and physical exercise frequency were linked tosuicidal thoughts, guilt, andpoor appetite or overeating.Suicidal thoughts, irritability, andguiltindicated the greatest connectivity with lifestyle factors. All networks had high stability and accuracy.ConclusionThese highlighted core and bridge symptoms could serve as latent targets for the prevention and intervention of comorbid depression and anxiety. It might be crucial for clinical practitioners to design effective and targeted treatment and prevention strategies aiming at specific lifestyles and behaviors.