This study aims to investigate the effect of management commitment (MC), supply chain integration (SCI), and government support (PGS) on small and medium enterprises (SMEs) innovation performance. The study was quantitative, and the cross-sectional method was used to gather 685 valid data through a structured questionnaire. Confirmatory factor analysis in Analysis of Moment Structures version 26 software was engaged in checking the constructs' validity. Hierarchical regression analysis was employed to examine the hypothesized relationships using Statistical Package for Social Sciences version 26 software. The regression analysis findings revealed that management commitment influenced the three dimensions of SCI (internal, customer, and supplier integration) and SMEs' innovation performance. The results from the mediation analysis indicated a partial mediation effect of internal, customer, and supplier integration in the relationship between management commitment and SMEs' innovation performance. Also, PGS significantly moderated the relationship between SCI and SMEs' innovation performance. The present study is critical as it explains the medium through which MC, SCI, PGS, and SMEs’ innovation performance relate in one conceptual model.