Key Summary PointsAimTo examine the association of psychotropic medication use with future unexplained and injurious falls and fracture in a large cohort of community-dwelling older people.FindingsPsychotropic medication use was independently associated with falls, unexplained falls and fracture. Antidepressants and anticholinergics were independently associated with future unexplained falls. Benzodiazepines and Z-drugs were not independently associated with falls.MessageRegular review of ongoing need for these medications should therefore be central to the comprehensive geriatric assessment.