There are several features inherent in blockchain, including decentralized storage, distributed ledger, immutability, security and authentication, and it has shifted away from the hype to be used practically in different industries, such as in the healthcare sector. The use of blockchain technology has allowed the provision of improved services to industries. The objective of this paper is to demonstrate how the use of blockchain is influenced by data quality issues in the healthcare industry. The article is structured as a systematic literature review study that uses several articles issued in various databases from 2016 onwards. In this review study, 65 articles were chosen and grouped into a single key aspect of the challenge in the healthcare sector. The findings obtained were analyzed based on factors in three domains, classified as issues pertinent to the adoption, operational and technological domains. This review study aims to use the findings to provide support to the practitioners, stakeholders and professionals, whose purpose is to carry out and manage transformation projects pertinent to blockchain in the field of healthcare. In addition, the organizations would be facilitated in their decision-making processes when the potential blockchain users are made to comprehend the implicit factors related to blockchain.