ObjectivesTo compare the clinical and radiographic outcomes of oblique lateral lumbar interbody fusion and minimally invasive transforaminal lumbar interbody fusion in patients with grade‐1 L4/5 degenerative spondylolisthesis.MethodsBased on the inclusion and exclusion criteria, the comparative analysis included consecutive patients with grade‐1 degenerative spondylolisthesis who underwent oblique LIF (OLIF,n= 36) or minimally invasive transforaminal LIF (MI‐TLIF,n= 45) at the Department of Spine Surgery, Beijing Jishuitan Hospital from January 2016 to August 2017. Patient satisfaction Japanese Orthopaedic Association score, visual analog scale (VAS) scores for back and leg pain, Oswestry disability index (ODI), radiographic outcomes including anterior/posterior disc heights (ADH/PDH), foraminal height (FH), foraminal width (FW), cage subsidence, cage retropulsion, and fusion rate were assessed during a 2‐year follow‐up. Continuous data are presented as mean ± standard deviation and were compared between groups using the independent sample t‐test. Categorical data are presented asn(%) and were compared between groups using the Pearson chi‐squared test or Fisher's exact test. Repetitive measurement and analysis of variance was employed in the analysis of ODI, back pain VAS score, and leg pain VAS score. Statistical significance was defined asp< 0.05.ResultsThe OLIF and MI‐TLIF groups comprised 36 patients (age, 52.1 ± 7.2 years; 27 women) and 45 patients (age, 48.4 ± 14.4 years; 24 women), respectively. Satisfaction rates at 2 years post procedure exceeded 90% in both groups. The OLIF group had less intraoperative blood loss (140 ± 36vs233 ± 62 mL), lower back pain VAS score (2.42 ± 0.81vs3.38 ± 0.47), and ODI score (20.47 ± 2.53vs27.31 ± 3.71) at 3 months follow‐up (with trends toward lower values at 2 years follow‐up), but higher leg pain VAS scores at all postoperative time points than the MI‐TLIF group (allp< 0.001). ADH, PDH, FD, and FW improved in both groups post‐surgery. At the 2 year follow‐up, the OLIF group had a higher rate of Bridwell grade‐I fusion (100%vs88.9%,p= 0.046) and lower incidences of cage subsidence (8.33%vs46.67%,p< 0.001) and retropulsion (0%vs6.67%,p= 0.046) than the MI‐TLIF group.ConclusionsIn patients with grade‐I spondylolisthesis, OLIF was associated with lower blood loss and greater improvements in VAS for back pain and ODI and radiologic outcomes than MI‐TLIF. The OLIF is more suitable for these patients with low back pain as the main symptoms are accompanied by mild or no leg symptoms before operation.