AbstractIn this study, the effective point of measurement (EPOM) for plane‐parallel ionization chambers in clinical high‐energy electron beams was determined experimentally. Previous studies have reported that the EPOM of plane‐parallel chambers is shifted several tens of millimeters downstream from the inner surface of the entrance window to the cavity. These findings were based on the Monte Carlo (MC) simulation, and few experimental studies have been performed. Thus, additional experimental validations of the reported EPOMs were required. In this study, we investigated the EPOMs of three plane‐parallel chambers (NACP‐02, Roos and Advanced Markus) for clinical electron beams. The EPOMs were determined by comparing the measured percentage depth‐dose (PDD) of the plane‐parallel chambers and the PDD obtained using the microDiamond detector. The optimal shift to the EPOM was energy‐dependent. The determined EPOM showed no chamber‐to‐chamber variation, thereby allowing the use of a single value. The mean optimal shifts were 0.104 ± 0.011, 0.040 ± 0.012, and 0.012 ± 0.009 cm for NACP‐02, Roos, and Advanced Markus, respectively. These values are valid in theR50range from 2.40 to 8.82 cm, which correspond to 6–22 MeV. Roos and Advanced Markus exhibited similar results to those of the previous studies, but NACP‐02 showed a larger shift. This is probably due to the uncertainty of the entrance window of NACP‐02. Therefore, it is necessary to carefully consider where the optimal EPOM is located when using this chamber.