The study aimed to compare the impact of Role Blurring on mental health and Work-Life Integration in the Brazilian and Spanish populations during COVID-19. Role Blurring, which is related to resources and demands in the work context, affects coping with stressors arising from role overlapping and impacts individuals’ perception of work overload and mental health. The sample consisted of 877 adults from Spain (n= 498) and Brazil (n= 372), and various statistical analyses were conducted to compare the groups. Results showed that Role Blurring is linked to symptoms of anxiety, depression, and stress, as well as suicidal ideation. Therefore, it is essential to promote working conditions that limit expectations on availability and favor disconnection from work during leisure time. Public policies that intervene, promote, and prevent psychosocial risk factors in emergent contexts are crucial to prevent suicidal ideation and attempts. Considering the high expected influence of Blurring as a focus of interventions can be reflected in the medium term in the indicators of well-being and satisfaction of companies, institutions and organizations. This can result in the reduction of health costs aimed at cushioning post-COVID-19 impacts on mental health. The study is relevant to understand the impact of the pandemic and technology on mental health and suggests the need for interventions to promote work-life balance and prevent psychosocial risks.