Highlights•We propose a series of structured recommendations, based on the consensus of international, multidisciplinary experts, on factors to consider before, during, and after physical activity/exercise, thus facilitating the advisory role of health professionals.•These recommendations include the systematic analysis of the degree of risk presented by patients with diabetic foot before starting unsupervised physical activity.•Patients at high risk of ulceration should be closely monitored, including during their return to activity after ulceration, and it is recommended that those with open ulcers or peripheral artery disease perform stretching and strengthening exercises.