A difficult-to-control outbreak ofCandida aurisis ongoing in a large tertiary care hospital in Liguria, Italy, where it first emerged in 2019. In a retrospective analysis, 503 cases ofC. auriscarriage or infection were observed between July 2019 and December 2022. Genomic surveillance identified putative cases that no longer occurred as part of one defined outbreak and the emergence of echinocandin (pandrug) resistance following independent selection ofFKS1S639FandFKS1F635Ymutants upon prolonged exposure to caspofungin and/or anidulafungin.