AbstractBackgroundMucormycosis is a life‐threatening invasive fungal infection in immunocompromised and COVID‐19 patients.Case ReportHere, we report a fatal rhino‐orbito‐cerebral mucormycosis caused byLichtheimia ramosa,in a 79‐year‐old diabetic female. She was initially admitted to the hospital for COVID‐19 infection and received broad‐spectrum antibiotics and corticosteroids. After 1 month, she was admitted again because of persistent headaches and decreased right eye movement when the computed tomography scan showed mucosal thickening and opacification of paranasal sinuses. Microbiological investigations, including culture and direct microscopy, and histopathological findings confirmed the diagnosis of proven mucormycosis. The isolated causal agent was identified asLichtheimia ramosaby sequencing the entire ITS region of nuclear ribosomal DNA. Despite surgical debridement and administration of liposomal amphotericin B 5 mg/kg/day, the patient's level of consciousness suddenly deteriorated; she was intubated and mechanically ventilated in the ICU and died on the same day.ConclusionTo our knowledge, this is the first worldwide case of COVID‐19‐associated rhino‐orbito‐cerebral mucormycosis due toLichtheimia ramosa.