Intestinal intussusception rarely occurs in adults and is challenging to diagnose in the emergency department due to its associated nonspecific symptom of abdominal pain. Most of these incidences are caused by a neoplasm within the bowel acting as a lead point. Lipomas are benign fatty tumors that rarely develop in the colon and are very infrequently a precursor lesion to intussusception. Our present report describes a case of lipoma-associated intussusception in the transverse colon in an adult who presented with complaints of abdominal pain and acutely worsened chronic constipation. Computerized tomography (CT) imaging and barium enema revealed colocolonic intussusception with a lipomatous lead point and complete obstruction. The patient was admitted for same-day intervention and underwent a successful colectomy with no complications.