Infections in severe burns and their etiology are and will remain a big concern for the medical field. The multi-drug resistant strains of bacteria are a challenge of today’s medicine. The aim of our study was to identify the etiological spectrum of bacterial infections in severe burn patients in Romania and their multi-drug resistant patterns. We performed a prospective study that included 202 adult patients admitted to the intensive care unit (ICU) of the Clinical Emergency Hospital of Plastic, Reconstructive Surgery and Burns, Bucharest, Romania (CEHPRSB), from 1 October 2018 to 1 April 2022, a period which includes the first 2 years of the outbreak of COVID-19. From each patient, wound swabs, endotracheal aspirates, blood for blood culture, and urine were collected. The most frequently isolated bacterium wasPseudomonas aeruginosa(39%), followed byStaphylococcus aureus(12%),Klebsiellaspp. (11%), andAcinetobacter baumannii(9%). More than 90% ofPseudomonas aeruginosaandAcinetobacter baumanniiwere MDR, regardless of the clinical specimen from which they were isolated.