Sexual satisfaction is a relevant indicator of sexual health, and psychotherapeutic interventions for sexual dysfunction also promote sexual satisfaction in men and women. Cognitive-behavioral psychotherapies for sexual dysfunction, including third-wave approaches, are effective in treating sexual dysfunction. Thus, third-wave cognitive-behavioral constructs may play a significant role in sexual satisfaction. This study intends to examine the predictive role of mindfulness awareness and attention, self-compassion and acceptance, and action constructs on cisgender heterosexual men’s and women’s sexual satisfaction. A web survey including self-report measures for assessing mindfulness awareness and attention (MAAS), self-compassion (SCS), acceptance and action (AAQ), and sexual satisfaction (GMSEX) was disseminated during 2022, and a sample of 420 participants was collected (n= 238 women; 56.7%;n= 182 men; 43.3%). No statistically significant differences were found between cisgender heterosexual men and women on mindfulness awareness and attention, self-compassion, acceptance and action, and sexual satisfaction. In addition, all variables account for 6.5% of cisgender heterosexual men’s and women’s sexual satisfaction variance, and mindfulness awareness and attention, self-compassion, and acceptance and action positively predicted sexual satisfaction. Overall, mindfulness awareness and attention, self-compassion, and acceptance and action play a significant predictive role in cisgender heterosexual men’s and women’s sexual satisfaction.