BackgroundHoffa’s fat pad syndrome has been defined as impingement of Hoffa’s fat pad, leading to oedema and fibrosis. The primary aim of this systematic review was to identify morphological differences in Hoffa’s fat pad between patients with and without Hoffa’s fat pad syndrome, evaluating them as risk factors predisposing to its development. The secondary aim was to summarize and evaluate current evidence pertaining to the management of Hoffa’s fat pad syndrome.Materials and MethodsThe protocol for this review was prospectively registered (PROSPERO registration: CRD42022357036). Electronic databases, currently registered studies, conference proceedings and the reference lists of included studies were searched. All studies evaluating differences in Hoffa’s fat pad anatomy under imaging between patients with and without Hoffa’s fat pad syndrome were included, as well as those exploring epidemiological factors predisposing to its development (ethnicity, employment status, sex, age and BMI), and studies reporting on the effect of treatment on Hoffa’s fat pad morphology.ResultsA total of 3871 records were screened. Twenty one articles satisfied the inclusion criteria, evaluating 3603 knees of 3518 patients. Patella alta, increased tibial tubercle-tibial groove distance, and increased trochlear angle were found to predispose the development of Hoffa’s fat pad syndrome. Trochlear inclination, sulcus angle, patient age and BMI were not associated with this condition. The link between Hoffa’s fat pad syndrome and ethnicity, employment, patellar alignment, Hoffa’s fat pad composition, physical activity and other pathological processes cannot be established due to lack of evidence. No studies reporting on treatment for Hoffa’s fat pad syndrome were identified. Though weight loss and gene therapy may provide symptomatic relief, further research is required to corroborate these claims.ConclusionCurrent evidence suggests that high patellar height, TT-TG distance, and trochlear angle predispose the development of Hoffa’s fat pad syndrome. In addition, trochlear inclination, sulcus angle, patient age and BMI do not seem to be associated with this condition. Further research should explore the link between Hoffa’s fat pad syndrome and sport as well as other conditions pertaining to the knee. In addition, further study evaluating treatment approaches for Hoffa’s fat pad syndrome is required.