Objectives: Mental health conditions in patients with coronary heart disease (CHD) are closely related to clinical outcomes. Thus, this study’s goal is to investigate how CHD affects general and specific aspects of mental health. Methods: We analyzed data from Wave 10 Understanding Society: the UK Household Longitudinal Study (UKHLS), which were collected between 2018 and 2019. After removing people who had missing data, there were 450 participants who indicated that they have CHD, and 6138 age- and sex-matched healthy participants indicated that they were not clinically diagnosed with CHD. Results: The main findings were that participants with CHD had more mental health problems, as shown by the GHQ-12 summary score (t (449) = 6.00,p< 0.001, 95% C.I. [0.20, 0.40], Cohen’s d = 0.30), social dysfunction and anhedonia, (t (449) = 5.79,p< 0.001, 95% C.I. [0.20, 0.40], Cohen’s d = 0.30), depression and anxiety (t (449) = 5.04,p< 0.001, 95% C.I. [0.15, 0.33], Cohen’s d = 0.24), and loss of confidence (t (449) = 4.46,p< 0.001, 95% C.I. [0.11, 0.30], Cohen’s d = 0.21). Conclusion: This study implies that GHQ-12 is a valid assessment of mental health problems in CHD patients, and there is a need to consider how different aspects of mental health are affected by CHD rather than solely focusing on depression or anxiety problems alone in patients with CHD.