IntroductionBone mineral density (BMD) is an essential indicator for diagnosing osteoporosis and evaluating the success of osteoporotic treatment. Dual-energy X-ray absorptiometry (DEXA), quantitative ultrasonography (QUS), and quantitative computed tomography (QCT) are frequently used for measuring BMD. The objective of the study was to evaluate the ability of QUS to screen for osteoporosis and bone density in postmenopausal women by calibrating it against DEXA.MethodsThis cross-sectional study was conducted at the Department of Orthopedics and Trauma Center of the tertiary care center, Lucknow. A total of 90 patients visited this department from August 2017 to July 2018 for the present study. BMD in the same patient was evaluated by using DEXA and ultrasonography methods. Data were entered in Microsoft Excel and analyzed by using SPSS Software.ResultsAccording to linear regression analysis, T neck was found statistically significant with T QUS (p<0.001) and z QUS (p<0.001). T lumbar and T wrist were found statistically significant with T QUS (p<0.001) but not with z QUS (p>0.001). Z neck was found statistically significant with T QUS (p<0.001) and z QUS (p<0.001). Z lumbar was found statistically significant with T QUS (p<0.001) but not with z QUS (p>0.005). Z wrist was not found statistically significant with T QUS (p>0.005) or with z QUS (p>0.005).ConclusionIn the present study, we found that QUS can be used as a screening tool for detecting osteoporosis by measuring BMD in contrast to DEXA. QUS also can be used to predict the DEXA values for osteoporosis and to detect osteoporosis.