Scutellaria baicalensisgeorgi, known as “Huangqin” in its dried root form, is a herb widely used in traditional Chinese medicine for “clearing away heat, removing dampness, purging fire and detoxification”. Baicalin, baicalein, wogonin, and wogonoside are the main flavonoid compounds found inScutellaria baicalensis. Scutellaria baicalensis flavonoid components have the potential to prevent and treat a host of diseases. The components of S. baicalensis have limited clinical application due to their low water solubility, poor permeability, and microbial transformationin vivo. Nanopharmaceutical techniques can improve their biopharmaceutical properties, enhance their absorptionin vivo, and improve their bioavailability. However, due to the limited number of clinical trials, doubts remain about their toxicity and improvements in human absorption as a result of nanoformulations. This review summarizes the latest and most comprehensive information regarding the absorption, distribution, metabolism, and excretion of theScutellaria baicalensiscomponentsin vivo. We examined the main advantages of nanodrug delivery systems and collected detailed information on the nanosystem delivery of theScutellaria baicalensiscomponents, including nanosuspensions and various lipid-based nanosystems. Lipid-based systems including liposomes, solid lipid nanoparticles, nanoemulsions, and self-micro emulsifying drug delivery systems are introduced in detail. In addition, we make recommendations for related and future research directions. Future research should further examine the absorption mechanisms and metabolic pathways of nanoformulations of the components ofScutellaria baicalensis in vivo, and accurately track thein vivobehavior of these drug delivery systems to discover the specific reasons for the enhanced bioavailability of nanoformulations of thescutellaria baicalensiscomponents. The development of targeted oral administration of intact nanoparticles ofScutellaria baicalensiscomponents is an exciting prospect.