Key PointsQuestionDoes lesion-related epilepsy map to a brain network?FindingsIn this case-control study of lesion locations in patients who either developed epilepsy or did not, lesions associated with epilepsy occurred in multiple heterogenous brain locations. However, these same lesion locations were part of a specific brain network defined by functional connectivity to the basal ganglia and cerebellum, and deep brain stimulation sites associated with seizure control were connected to this same network.MeaningThe findings indicate that lesion-related epilepsy mapped to a brain network that could help identify patients at risk of epilepsy after a brain lesion and guide brain stimulation therapies.