We report a catalytic protocol for mild OtBu deprotection
using two commercial reagents: the tris-4-bromophenylamminium radical
cation, commonly known as magic blue (MB•+), and
triethylsilane. Magic blue catalytically facilitates the cleavage
of the C–O bond intert-butyl carbamates,
carbonates, esters, and ethers in a high isolated yield of up to 95%,
and sacrificial triethylsilane accelerates the reaction. Without requiring
high temperatures, transition metals, or strong acidic or basic catalysts,
this method is suitable for structurally diverse compounds, including
aliphatic, aromatic, and heterocyclic substrates.