Simple SummaryThis study developed a prediction model for late bladder toxicity in patients with uterine cervical cancer undergoing radiation therapy. A deep learning (DL) model was trained on data from 281 patients and compared its performance with a multivariable logistic regression model. The DL model outperformed the regression model, achieving higher accuracy, recall, F1-score, and area under the receiver operating characteristic curve. Specifically, based on the feature importance analysis, the DL model identified the doses for the most exposed 2 cc volume of the bladder (BD2cc), BD5cc, and ICRU bladder point as high-priority features. Finally, the lightweight DL model, which was designed to focus on the top five important features, demonstrated superior predictive capabilities, highlighting its potential in improving patient outcomes and minimizing treatment-related complications with secured reliability.Abstract(1) In this study, we developed a deep learning (DL) model that can be used to predict late bladder toxicity. (2) We collected data obtained from 281 uterine cervical cancer patients who underwent definitive radiation therapy. The DL model was trained using 16 features, including patient, tumor, treatment, and dose parameters, and its performance was compared with that of a multivariable logistic regression model using the following metrics: accuracy, prediction, recall, F1-score, and area under the receiver operating characteristic curve (AUROC). In addition, permutation feature importance was calculated to interpret the DL model for each feature, and the lightweight DL model was designed to focus on the top five important features. (3) The DL model outperformed the multivariable logistic regression model on our dataset. It achieved an F1-score of 0.76 and an AUROC of 0.81, while the corresponding values for the multivariable logistic regression were 0.14 and 0.43, respectively. The DL model identified the doses for the most exposed 2 cc volume of the bladder (BD2cc) as the most important feature, followed by BD5ccand the ICRU bladder point. In the case of the lightweight DL model, the F-score and AUROC were 0.90 and 0.91, respectively. (4) The DL models exhibited superior performance in predicting late bladder toxicity compared with the statistical method. Through the interpretation of the model, it further emphasized its potential for improving patient outcomes and minimizing treatment-related complications with a high level of reliability.