IntroductionThere is a dearth of information about the food variety and consumption scores of adolescents in Ghana. This study assessed predictors of food variety and consumption scores of adolescents living in a rural district in Ghana.MethodIn this cross-sectional study, a multi-stage sampling method was used to select one hundred and thirty-seven (137) adolescents from the Asante-Akim South Municipality of Ghana. A structured questionnaire was used to collect data on sociodemographic, food practices and dietary intakes of study participants. Descriptive, chi-square, T-test, partial correlation and binary logistic regression were used for the data analysis.ResultsThe mean food variety score was 25.8±6.4 (range 7–42) and food consumption score was 35±5.1 (range 18.6–49.9). Food variety score was significantly (p<0.05) associated with guardian income status. A significant and positive partial correlation existed between food variety score and calcium intake (r = 0.236, p<0.05). About 49% and 51% of adolescents were food insecure and food secure, respectively. Food consumption score had significant association (p<0.05) with gender (X2= 6.1), residence (X2= 7.0), frequency of meal (X2= 6.8) and food variety score (X2= 5.4). Adolescent male (AOR = 2.3, 95% CI (1.2–4.6), p = 0.017), peri-urban residency (AOR = 2.1, 95%CI (1.0–4.4), p = 0.036), having three or more meals per day (AOR = 4.2, 95% CI (1.3–13.6), p = 0.018), and a high food variety score (AOR = 2.1, 95%CI (1.0–4.2), p = 0.041) significantly predicted food consumption scores.ConclusionModerate income status was associated with food variety score in our study participants. Linear relationship existed between food variety and calcium intake. Adolescent males, peri-urban residency, frequency of meals and high food variety score were the predictors of food consumption score. Nutrition-specific and nutrition sensitive programmes aimed at promoting adolescent health should involve guardians.