PurposeThe aim of the study is to describe a case where Femtosecond Intrastromal Lenticule Extraction was used to address the refractive defect following topography-guided phototherapeutic keratectomy (topo-PTK) to regularise a scarred corneal surface after an initial LASIK flap formation attempt failed.ObservationsA 23-year-old female experienced a thin and irregular corneal flap, during a microkeratome LASIK surgery of the right eye. Subsequently, she experienced epithelial ingrowth. Three months postoperatively the cornea showed scarring and partial flap melting. Topo-PTK was employed to ablate the scarred surface rendering it regular. Treatment with Femtosecond Intrastromal Lenticule Extraction was performed to correct the final refractive error of Sph −5.50 Cyl −2.00 Axis 180° with a happy end of uncorrected visual acuity (UCVA) of 20/20.Conclusions and ImportanceFemtosecond Intrastromal Lenticule Extraction can be used for retreatment after surface ablation. Topo-PTK can be used to ablate post-operative LASIK-induced irregularities with a successful outcome.