AbstractDisruptive innovation is needed to raise the threshold of sustainable building performance, so that our buildings improve on net zero impacts and have a life‐promoting impact on the natural world. This article outlines a new approach to next‐generation sustainable architecture, which draws on the versatile metabolisms of microbes as a platform by incorporating microbial technologies and microbially produced materials into the practice of the built environment. Theregenerative architecturearising from these interventions includes a broad range of advances from using new materials, to creating bioreceptive surfaces that promote life, and providing green, bio‐remediating energy from waste. Such innovations are presently reaching the marketplace as novel materials like Biocement® with lower embodied carbon than conventional materials that adopt microbially facilitated processes, and as novel utilities like PeePower® that transforms urine into electrical energy and bioreactor‐based building systems such as the pioneering BIQ building in Hamburg. While the field is still young, some of these products (e.g. mycelium biocomposites) are poised for uptake by the public–private economic axis to become mainstream within the building industry. Other developments are creating new economic opportunities for local maker communities that empower citizens and catalyse novel vernacular building practices. In particular, the activation of themicrobial commonsby the uptake of microbial technologies and materials through daily acts of living, ‘democratises’ resource harvesting (materials and energy) in ways that sustain life, and returns important decisions about how to run a home back to citizens. This disruptive move re‐centres the domestic‐commons economic axis to the heart of society, setting the stage for new vernacular architectures that support increasingly robust and resilient communities.