This study aimed to examine the comprehensive impact of five aspects of the nursing work environment as well as supervisory support, nurse characteristics, and burnout on intent to stay (ITS) among Korean hospital nurses. A cross-sectional questionnaire was distributed in seven general hospitals from May to July of 2019. Data were collected from a sample of 631 Korean nurses. The hypothesized model was evaluated using the STATA program for path models. Findings demonstrated that burnout played a mediating role on the relationships between the nursing work environment, supervisory support, nurse characteristics, and ITS. Burnout was the most influential predictor of ITS (β= −0.36,p< 0.001). Nurse participation in hospital affairs (β= 0.10,p= 0.044) and collegial nurse–physician relationships (β= 0.08,p= 0.038) had a direct effect on ITS. Supervisory support had a significant direct effect on ITS (β= 0.19,p< 0.001). Therefore, to increase nurses’ ITS, it is necessary to improve their participation in hospital affairs and collegial relationships, as well as strengthen support from supervisors and reduce burnout.