Speed is key during infectious disease outbreaks. It
is essential,
for example, to identify critical host binding factors to pathogens
as fast as possible. The complexity of host plasma membrane is often
a limiting factor hindering fast and accurate determination of host
binding factors as well as high-throughput screening for neutralizing
antimicrobial drug targets. Here, we describe a multiparametric and
high-throughput platform tackling this bottleneck and enabling fast
screens for host binding factors as well as new antiviral drug targets.
The sensitivity and robustness of our platform were validated by blocking
SARS-CoV-2 particles with nanobodies and IgGs from human serum samples.