The study investigates some biological indices and chemical compositions of Callinectes amnicola and their potential for reuse in the context of the circular economy paradigm. The total of 322 mixed-sex C. amnicola collected over a period of six months was examined. The morphometric and meristic characteristics were estimated for biometric assessment. The gonads were obtained from the female crabs for gonadosomatic indices. The shell was obtained using the hand removal technique by detaching it from the crab body. The edible and shell portions were processed separately and subjected to chemical analysis. Our findings showed that females had the highest sex ratio across the six months. The slope values (b) for both sexes exhibited negative allometric growth across all months since the slope values obtained were less than 3 (b < 3). The values obtained for Fulton’s condition factor (K) of crabs in all examined months were greater than 1. The edible portion had the highest moisture level at 62.57 ± 2.16% and varied significantly (P< 0.05). The high amount of total ash obtained in the shell sample showed that ash is the main mineral present in crab shells and showed a significant difference (P< 0.05). The shell sample had the highest concentrations of Na and CaCO3. Based on the findings of this study, it was observed that the shell waste contains some essential and transitional minerals (Ca, CaCO3, Na, and Mg) and can be utilized as catalysts in several local and industrial applications, such as pigments, adsorbents, therapeutics, livestock feeds, biomedical industries, liming, fertilization, and so on. Proper valorization of this shell waste should be encouraged rather than discarding it.