With the normalization of epidemic prevention and control, air filters are being used and replaced more frequently. How to efficiently utilize air filter materials and determining whether they have regenerative properties have become current research hotspots. This paper discusses the regeneration performance of reduced graphite oxide filter materials, which were studied in depth using water cleaning and the relevant parameters, including the cleaning times. The results showed that water cleaning was most effective using a 20 L/(s·m2) water flow velocity with a 17 s cleaning time. The filtration efficiency decreased as the number of cleanings increased. Compared to the blank group, the filter material’s PM10filtration efficiency decreased by 0.8%, 19.4%, 26.5%, and 32.4% after the first to fourth cleanings, respectively. The filter material’s PM2.5filtration efficiency increased by 12.5% after the first cleaning, and decreased by 12.9%, 17.6%, and 30.2% after the second to fourth cleanings, respectively. The filter material’s PM1.0filtration efficiency increased by 22.7% after the first cleaning, and decreased by 8.1%, 13.8%, and 24.5% after the second to fourth cleanings, respectively. Water cleaning mainly affected the filtration efficiency of particulates sized 0.3–2.5 μm. Reduced graphite oxide air filter materials could be water washed twice and maintain cleanliness equal to 90% of the original filter material. Water washing more than twice could not achieve the standard cleanliness equal to 85% of the original filter material. These data provide useful reference values for the evaluation of the filter materials’ regeneration performance.