Brucellaspp.,Toxoplasma gondii, andChlamydia abortushave long been recognized as zoonoses and significant causes of reproductive failure in small ruminants globally. A cross-sectional study was conducted in August 2020 to determine the seroprevalences ofBrucellaspp.,Toxoplasma gondiiandChlamydia abortusin 398 small ruminants from four districts of Zimbabwe (Chivi, Makoni, Zvimba, and Goromonzi) using Indirect-ELISAs. A structured questionnaire was used to assess the knowledge, attitudes, and practices of 103 smallholder farmers towards small ruminant abortions,Brucellaspp.,T.gondiiandC.abortus, and to obtain a general overview of the significance of small ruminant reproductive failure(s) on their livelihoods. The overall seroprevalences were: 9.1% (95% CI: 6.4–12.3) forBrucellaspp., 6.8% (95% CI: 4.5–9.7) forT.gondiiand 2.0% (95% CI: 0.9–3.9) forC.abortus. Location, age, parity, and abortion history were associated withBrucellaspp. seropositivity. Location was also associated with bothT.gondiiandC.abortusseropositivity. The questionnaire survey established that 44% of respondents had recently faced reproductive disease challenges within their flocks, with 34% correctly identifying abortion causes and only 10%, 6% and 4% having specific knowledge ofBrucellaspp.,C.abortusandT.gondii, respectively. This study provides the first serological evidence ofBrucellaspp. in small ruminants since 1996 and builds the evidence on small ruminant toxoplasmosis and chlamydiosis in Zimbabwe. Evidence of these zoonoses in small ruminants and the paucity of knowledge shows the need for a coordinated One Health approach to increase public awareness of these diseases, and to establish effective surveillance and control measures. Further studies are required to establish the role these diseases play in small ruminant reproductive failure(s), to identify theBrucellaspp. detected here to species/subspecies level, and to assess the socio-economic impact of reproductive failure in livestock among marginalised rural communities.