The current global pandemic due to the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus has demonstrated the necessity
to develop novel materials with antimicrobial and antiviral activities
to prevent the infection. One significant route for the spread of
diseases is by the transmission of the virus through contact with
contaminated surfaces. Antiviral surface treatments can help to reduce
or even avoid these hazards. In particular, the development of active-virucidal
fabrics or paints represents a very important challenge with multiple
applications in hospitals, public transports, or schools. Modern,
cutting-edge methods for creating antiviral surface coatings use either
materials with a metal base or sophisticated synthetic polymers. Even
if these methods are effective, they will still face significant obstacles
in terms of large-scale applicability. Here, we describe the preparation
of fabrics and paints treated with a scaled-up novel nanostructured
biohybrid material composed of very small crystalline phosphate copper(II)
nanoparticles, synthesized based on a technology that employs the
use of a small amount of biological agent for its formation at room
temperature in aqueous media. We demonstrate the efficient inactivation
of the human coronavirus 229E (HCoV-229E), the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus, and non-enveloped human
rhinovirus 14 (HRV-14) (>99.9%) using an inexpensive, ecologically
friendly coating agent. The reactive oxygen species produced during
the oxidation of water or the more intensive reaction with hydrogen
peroxide are believed to be the cause of the antiviral mechanism of
the nanostructured material. In contrast to the release of a specific
antiviral drug, this process does not consume the surface coating
and does not need regeneration. A 12-month aging research that revealed
no decline in antiviral activity is proof that the coating is durable
in ambient circumstances. Also, the coated fabric can be reused after
different washing cycles, even at moderate to high temperatures.