BackgroundCOVID-19 has gravely affected the world, including students, due to the high level of contracting infections.ObjectiveThis study assessed the magnitude of mask use and associated factors among students.MethodsA cross-sectional study using mixed methods was conducted among students at Gambella Teachers’ Education and Health Science College, Gambella Region, Southwest Ethiopia, from March 5 to March 30, 2021. The stratified random sampling technique was used. Proportional allocation of samples was used to randomly select case teams, and a simple random sampling technique was used to recruit the students. The data were collected by trained and experienced enumerators. Data were entered into EpiData (version 3.1; EpiData Association) and exported to SPSS (version 22; IBM Corp) for analysis. Logistic regression was executed. The adjusted odds ratio (AOR) with the 95% CI was used to determine the association and strength with the outcome variable. The qualitative data were transcribed, translated, coded, and analyzed using thematic analysis. Then, the themes were used to triangulate the quantitative study.ResultsThe study included a total of 379 participants and yielded a response rate of 95.5% (379/397). The majority of study participants were older than 25 years, with the mean age being 26.34 (SD 5.8) years. This study found that the magnitude of mask use among students was 87% (330/379). The odds of mask use were higher among students who were female (AOR 3.32, 95% CI 1.191-9.248), younger (AOR 2.55, 95% CI 1.155-5.627), agreed that not all persons with COVID-19 develop severe disease (AOR 3.38, 95% CI 1.36-8.41), agreed that there is currently no effective cure (AOR 6.28, 95% CI 1.36-28.99), performed proper washing with soap and water (AOR 0.027, 95% CI 0.004-0.182), had started to stay home (AOR 0.168, 95% CI 0.054-0.52), agreed that COVID-19 is fatal (AOR 0.236, 95% CI 0.084-0.666), agreed that a flu vaccine is sufficient for COVID-19 prevention (AOR 3.874, 95% CI 1.540-9.749), and disinfected equipment and working areas at least once a day (AOR 0.222, 95% CI 0.086-0.575).ConclusionsThis study found that the magnitude of mask use among students was relatively moderate in Ethiopia. Sex, age, agreeing that not all persons with COVID-19 develop severe disease, agreeing that there is currently no effective cure, performing proper washing with soap and water, starting to stay home, agreeing that COVID-19 is fatal, and agreeing that the flu vaccine is sufficient to prevent COVID-19 were independently associated with mask use among students. Therefore, colleges should aggressively encourage students to wear masks and monitor the implementation of COVID-19 prevention regulations along with the accessibility of masks.