AbstractIschemic colitis accounts for many cases of bowel infarction. Usually, it has various manifestations, such as vomiting, abdominal pain, hematochezia and many other symptoms. Risk factors might include age, medications, hypercoagulable state and chronic illnesses. However, it can still occur in healthy young patients. This might make it difficult for physicians to establish a correct diagnosis and generate the appropriate treatment plan for patients suffering from ischemic colitis. In this case we report a previously healthy 37-year-old female who had a sudden onset of lower abdominal pain associated with hematochezia. This patient was treated for upper respiratory tract infection by amoxicillin-clavulanate 2 weeks prior to her symptoms. The computed tomography abdomen findings along with the exploratory laparotomy confirmed the diagnosis of ischemic colitis. Ischemic colitis is a serious condition with high mortality and morbidity rate. Therefore, prompt investigation, and if indicated, surgical intervention should be calculated in sick patients complaining of abdominal pain and lower gastrointestinal bleeding.