ABSTRACTBackgroundIn Korea, winter can cause skin dryness due to low relative humidity (RH); moreover, indoor heating devices promote moisture loss and air pollution. If dryness persists, dead skin cells accumulate, leading to skin problems; therefore, careful skin care is required. This study aimed to compare changes in skin conditions when exposed to an indoor environment for a short period of 6 h in winter, and to suggest proper winter skin care practices.MethodsA randomized, split‐face clinical study was conducted in which healthy female participants with normal skin were exposed to an indoor environment with a heater turned on for a short period at least 6 h per day in the winter season, and cream was applied to one side of the face. Skin temperature, hydration, sebum, transepidermal water loss (TEWL), elasticity, texture, pores, redness, and wrinkles were measured at the treated and nontreated sites.ResultsAfter 6 h of exposure, skin temperature, pores, roughness, redness, and wrinkles significantly increased (p< 0.05) on the face, whereas TEWL significantly increased on the forearm (p< 0.05). However, sebum secretion appeared to function as a barrier to maintain homeostasis in the facial skin. Elasticity, pores, texture, and wrinkles in the cream‐treated ceramide site improved compared to those in the nontreated site (p< 0.05). The moisture content was also significantly higher in the forearm (p< 0.05).ConclusionChanges in skin parameters of participants with healthy skin were observed even after short‐term exposure to an indoor environment in winter. Creams containing ceramide maintain skin homeostasis and protect the skin barrier; therefore, it is recommended to use such creams to prevent skin damage and maintain healthy skin, particularly during prolonged exposure to indoor environments during winter.