AbstractObjectiveTo report the efficacy of office‐based blue laser therapy for vocal fold leukoplakia.Study DesignA retrospective case series.SettingA tertiary care center.MethodsA retrospective chart review of patients with vocal fold leukoplakia who underwent office‐based blue laser therapy between July 2019 and October 2022 was conducted. The video recordings of their laryngeal examination and their voice evaluation were analyzed before and after surgical intervention.ResultsA total of 10 patients, eight with unilateral disease and 2 with bilateral disease, were included in this study. In total, 12 vocal folds with leukoplakia were treated. Nine had a single session and 3 had 2 sessions due to incomplete regression of the lesion after the first laser therapy session. Following treatment, 9 regressed completely (75%) and 3 regressed partially (25%). The mean Voice Handicap Index‐10 (VHI‐10) score decreased significantly from 15.4 ± 12.9 preoperatively to 3.8 ± 2.86 after surgery (p= .023). There was a statistically significant decrease in the means of grade, roughness, breathiness, asthenia, and strain (p< .05). There was also a statistically significant decrease in the jitter and shimmer percent (p= .008 andp= .048, respectively) and a significant increase in the maximum phonation time from 9.63 ± 3.83 to 13.54 ± 5.92 seconds (p= .039).ConclusionThis preliminary study indicates that office‐based blue laser therapy is an effective treatment modality for vocal fold leukoplakia.