ABSTRACTAcute hepatitis E virus (HEV) infection in the United States of America (U.S.A) is low. However, seroprevalence rate is about of 6%. Most cases of HEV infection have been reported from travelers from endemic countries with poor sanitary conditions. Evidence of HEV as a zoonotic infection has been reported from developed countries from swine and wild animals including boar and deer. There is no reported case of direct transmission from wild game to humans in the U.S.A. We report a case of HEV from butchering of deer meat.