ObjectiveTo elucidate through a systematic literature review the impact sperm DNA
fragmentation has on embryos from assisted reproduction techniques.Data SourceStudies from the “PubMed”, “Embase”, and “BVS” databases were analyzed.Studies SelectionThe articles selected in the review included: cohort and case-control studies
that addressed the proposed theme, published between January 1, 2017, and
January 31, 2022, in English, Portuguese, and Spanish. As inclusion
criteria: cohort and case-control articles. As exclusion criteria: articles
outside the scope of the research, review articles, case reports, articles
using animal models, abstracts, letters to the editor, and articles found
duplicates in the databases.Data CollectionNumber of couples or cycles; age (men/women); collection type; DNA damage
(%); assisted reproduction activity and techniques.Data SynthesisIn in vitrofertilization, a reduction in fertilization
rate, blastocyst rate, and embryo quality was observed. In addition to
implantation and increased abortion rates in patients with high sperm DNA
fragmentation. High rates of sperm DNA fragmentation in intracytoplasmic
sperm injection led to reduced blastocyst production rate, embryo quality,
implantation, and live birth rate, and in intrauterine insemination, a
reduction in pregnancy rate.ConclusionSperm DNA fragmentation was a potential limiting factor for assisted
reproduction techniques.