Zinc oxide is a crucial component in rubber products, but its excessive usage can lead to environmental damage. As a result, reducing the amount of zinc oxide in products has become a critical issue that many researchers aim to address. This study employs a wet precipitation method to prepare ZnO particles with different nucleoplasmic materials, resulting in ZnO with a core–shell structure. The prepared ZnO underwent XRD, SEM, and TEM analysis, indicating that some of the ZnO particles were loaded onto the nucleosomal materials. Specifically, ZnO with a silica core–shell structure demonstrated 11.9% higher tensile strength, 17.2% higher elongation at break, and 6.9% higher tear strength compared to the indirect method of ZnO preparation. The core–shell structure of ZnO also helps reduce its application in rubber products, thereby achieving the dual objective of protecting the environment and improving the economic efficiency of rubber products.