The human brain has evolved to solve the problems it encounters in multiple environments. In solving these challenges, it forms mental simulations about multidimensional information about the world. These processes produce context-dependent behaviors. The brain as overparameterized modeling organ is an evolutionary solution for producing behavior in a complex world. One of the most essential characteristics of living creatures is that they compute the values of information they receive from external and internal contexts. As a result of this computation, the creature can behave in optimal ways in each environment. Whereas most other living creatures compute almost exclusively biological values (e.g., how to get food), the human as a cultural creature computes meaningfulness from the perspective of one’s activity. The computational meaningfulness means the process of the human brain, with the help of which an individual tries to make the respective situation comprehensible to herself to know how to behave optimally. This paper challenges the bias-centric approach of behavioral economics by exploring different possibilities opened up by computational meaningfulness with insight into wider perspectives. We concentrate onconfirmation biasandframing effectas behavioral economics examples of cognitive biases. We conclude that from the computational meaningfulness perspective of the brain, the use of these biases are indispensable property of an optimally designed computational system of what the human brain is like. From this perspective, cognitive biases can be rational under some conditions. Whereas the bias-centric approach relies on small-scale interpretable models which include only a few explanatory variables, the computational meaningfulness perspective emphasizes the behavioral models, which allow multiple variables in these models. People are used to working in multidimensional and varying environments. The human brain is at its best in such an environment and scientific study should increasingly take place in such situations simulating the real environment. By using naturalistic stimuli (e.g., videos and VR) we can create more realistic, life-like contexts for research purposes and analyze resulting data using machine learning algorithms. In this manner, we can better explain, understand and predict human behavior and choice in different contexts.