Highly anisotropic single-molecule magnets (SMMs) have attracted much interest in the field of molecular magnetism because of their spin features and potential technological applications. Additionally, a great effort has been devoted to the functionalization of such molecule-based systems which are made with ligands containing functional groups suitable to connect SMMs to junction devices or to perform their grafting on surfaces of different substrates. We have synthesized and characterized two lipoic acid-functionalized and oxime-based Mn(III) compounds, of formula [Mn6(μ3-O)2(H2N-sao)6(lip)2(MeOH)6][Mn6(μ3-O)2(H2N-sao)6(cnph)2(MeOH)6]}·10MeOH (1) and [Mn6(μ3-O)2(H2N-sao)6(lip)2(EtOH)6]·EtOH·2H2O (2) [H2N-saoH2= salicylamidoxime, lip = lipoate anion, cnph = 2-cyanophenolate anion]. Compound1crystallizes in the space groupPī of the triclinic system and2crystallizes in the space group C2/c of the monoclinic system. In the crystal, neighboring Mn6entities are linked using non-coordinating solvent molecules, which are H-bonded to N atoms of –NH2groups of amidoxime ligand. In addition, Hirshfeld surfaces of1and2were calculated to study the variety of intermolecular interactions and the different levels of importance that take place in their crystal lattice; this type of computed study is the first time performed on Mn6complexes. The study of the magnetic properties of1and2through dc magnetic susceptibility measurements reveals the coexistence of ferromagnetic and antiferromagnetic exchange couplings between the Mn(III) metal ions in both compounds, the latter being the predominant magnetic interaction. A spin S = 4 value of the ground state was obtained using isotropic simulations of the experimental magnetic susceptibility data for both1and2. Ac magnetic susceptibility measurements show features typical of slow relaxation of the magnetization in1and2, which indicate that SMM behavior takes place in both compounds.