Key PointsQuestionIs regular statin intake associated with a reduced rate of new liver diseases and liver-related death in the general population?FindingsThis cohort study, involving more than 1.7 million people after matching, found that regular use of statins was associated with a 15% lower hazard ratio of new-onset liver disease and a 28% lower hazard ratio for liver-related deaths compared with no statin use. Moreover, a decrease in hazard ratio of up to 74% was demonstrated for hepatocellular carcinoma in regular statin users compared with non–statin users.MeaningThese findings suggest that statins may be a therapeutic option for liver disease prevention and should be examined in further studies.