Vasovagal syncope has been associated with chronic pain procedures, phlebotomy, and musculoskeletal injections. While vasovagal syncope is commonly associated with interventional pain procedures, its occurrence during peripheral nerve block procedures has not been reported. We report a case of vasovagal syncope leading to transient asystole in a patient undergoing a lower extremity peripheral nerve block procedure. The episode resolved after halting the procedure and administering ephedrine, atropine, and intravenous fluids.