Key PointsQuestionWhat are the genetic risk factors associated with preeclampsia and hypertensive disorders of pregnancy?FindingsIn this genome-wide association study, 13 novel preeclampsia- or hypertensive pregnancy–associated genetic loci were discovered. Seven loci are located near genes previously associated with blood pressure traits, and several harbor genes involved in the development of placenta, remodeling of uterine spiral arteries, and kidney function.MeaningThe findings further strengthen the known association between cardiovascular health and preeclampsia and provide new targets for future research of preeclampsia pathophysiology, including genes involved in placental development and kidney function.