ObjectiveThe present study aims to investigate the association betweencaspase-8(CASP8) (rs13416436 and rs2037815) andFas cell surface death receptor(FAS) (rs3740286 and rs4064) polymorphisms with endometriosis in Brazilian women.MethodsIn the present case-control study, 45 women with a diagnosis of endometriosis and 78 normal healthy women as a control group were included. The genotyping was determined by real-time polymerase chain reaction (PCR) with Taqman hydrolysis probes (Thermo Fisher Scientific, Darmstadt, Germany). Genotypic and allelic frequencies were analyzed using Chi-squared (χ2) test. In order to determine the inheritance models and haplotypes ,SNPStats (Institut Català d'Oncologia, Barcelona, Spain) was used. Levels of 5% (p= 0.05) were considered statistically significant.ResultsNo significant difference was observed in genotypic or allelic frequencies between control and endometriosis groups for rs13416436 and rs2037815 (CASP8gene). On the other hand, a significant difference between rs3740286 and rs4064 (FASgene) was found. Regarding polymorphisms in theFASgene, a statistically significant difference was found in co-dominant and dominant models. Only the haplotype containing the rs3740286A and rs4064G alleles in theFASgene were statistically significant.ConclusionThe polymorphisms in theCASP8gene were not associated with endometriosis. The results indicate an association betweenFASgene polymorphisms and the risk of developing endometriosis.