Even thoughHelicobacter pylori(H. pylori) is a serious pathogen, its origin is unknown. Poultry (Chicken, Turkey, Quebec, Goose, and Ostrich) are consumed as a regular protein source by a large number of people across the world; therefore, sanitary ways of delivering poultry for food are important for global health. As a result, we looked at the distribution of the pathogenicitycagA, vacA, babA2, oipA, and iceAinH. pyloriisolates in poultry meat, as well as their antimicrobial resistance. Wilkins Chalgren anaerobic bacterial medium was used to cultivate 320 raw poultry specimens. Disk diffusion and Multiplex-PCR were used to investigate antimicrobial resistance and genotyping patterns, separately.H. pyloriwas found in 20 of 320 (6.25%) raw poultry samples. The highest incidence ofH. pyloriwas found in chicken raw meat (15%), whereas the fewest was found in Goose and Quebec (0.00%). Resistance to ampicillin (85%), tetracycline (85%), and amoxicillin (75%) were greatest inH. pyloriisolates. The percentage ofH. pyloriisolates with a MAR value of more than 0.2 was 17/20 (85%). The most prevalent genotypes discovered wereVacA s1a(75%),m1a(75%),s2(70%) andm2(65%), andcagA(60%). The most typically discovered genotype patterns weres1am1a(45%),s2m1a(45%), ands2m2(30%).BabA2, OipA+, and OipA−genotypes were found in 40%, 30%, and 30% of the population. In summary, the poultry flesh was polluted byH. pylori, withthe babA2, vacA, and cagAgenotypes being more prevalent. The simultaneous occurrence ofvacA, cagA, iceA, oipA, and babA2genotypes in antibiotic-resistantH. pyloribacteria implies a serious public health concern about raw poultry eating. In the future, researchers should look intoH. pylori'sresistance to multiple antibacterial drugs in Iran.