BackgroundAlthough it is known that excessive intraoperative fluid and vasopressor agents are detrimental for anastomotic healing, optimal anesthesiology protocols for colorectal surgery are currently lacking.ObjectiveTo scrutinize the current hemodynamic practice and vasopressor use and their relation to colorectal anastomotic leakage.DesignA secondary analysis of a previously published prospective observational study: the LekCheck study.Study settingAdult patients undergoing a colorectal resection with the creation of a primary anastomosis.Outcome measuresColorectal anastomotic leakage (CAL) within 30 days postoperatively, hospital length of stay and 30-day mortality.ResultsOf the 1548 patients, 579 (37%) received vasopressor agents during surgery. Of these, 201 were treated with solely noradrenaline, 349 were treated with phenylephrine, and 29 received ephedrine. CAL rate significantly differed between the patients receiving vasopressor agents during surgery compared to patients without (11.8% vs 6.3%,p< 0.001). CAL was significantly higher in the group receiving phenylephrine compared to noradrenaline (14.3% vs 6%,p< 0.001). Vasopressor agents were used more often in patients treated with Goal Directed Therapy (47% vs 34.6%,p< 0.001). There was a higher mortality rate in patients with vasopressors compared to the group without (2.8% vs 0.4%,p= 0.01, OR 3.8). Mortality was higher in the noradrenaline group compared to the phenylephrine and those without vasopressors (5% vs. 0.4% and 1.7%, respectively,p< 0.001). In multivariable analysis, patients with intraoperative vasopressor agents had an increased risk to develop CAL (OR 2.1, CI 1.3–3.2,p= 0.001).ConclusionThe present study contributes to the evidence that intraoperative use of vasopressor agents is associated with a higher rate of CAL. This study helps to create awareness on the (necessity to) use of vasopressor agents in colorectal surgery patients in striving for successful anastomotic wound healing. Future research will be required to balance vasopressor agent dosage in view of colorectal anastomotic leakage.