AbstractGadopentetate dimeglumine (Gd‐DTPA) is commonly used for enhancement in magnetic resonance imaging, but rarely causes serious adverse reactions. The patient presented in this report had a cardiac arrest and multiple organ dysfunction syndrome within a short time after administration of Gd‐DTPA. Immediately after receiving an intravenous injection of Gd‐DTPA, the patient felt nausea and chest tightness, and developed systemic erythema. He was successfully treated using veno‐arterial extracorporeal membrane oxygenation (ECMO) combined with continuous renal replacement therapy without any serious complications or neurological deficits. We report a patient who was successfully treated for Gd‐DTPA‐induced cardiac arrest with ECMO. Thus, ECMO may be an effective treatment for cardiac arrest secondary to anaphylaxis.