Secondary metabolites from marine organisms are diverse in structure and function. MarineAspergillusis an important source of bioactive natural products. We reviewed the structures and antimicrobial activities of compounds isolated from different marineAspergillusover the past two years (January 2021–March 2023). Ninety-eight compounds derived fromAspergillusspecies were described. The chemical diversity and antimicrobial activities of these metabolites will provide a large number of promising lead compounds for the development of antimicrobial agents.