ObjectiveThe present study aimed to examine the ameliorative effects of Morin (MRN) on
Bisphenol-A (BPA)-induced oxidative stress in testicular mitochondria and
sperm quality of rats.MethodsBPA and MRN (25, 50, and 100 µM) were given to the spermatozoa and
testicular tissue mitochondria. The sperm quality, mitochondrial viability,
and MMP (mitochondrial membrane potential) were examined. Superoxide
dismutase, CAT (catalase), malondialdehyde, and reactive oxygen species
(ROS) levels of rat testicular mitochondria were measured.ResultsBPA raised mitochondrial oxidative stress biomarkers, whereas antioxidant
acclivity and MMP were significantly lowered. BPA significantly lowered the
normality, viability, and motility of the sperms. MRN dose-dependently
lowered oxidative stress of the mitochondria, raised MMP, as well as
improved the percentage of abnormality, motility, and viability of the
sperms.ConclusionsThese data demonstrated that MRN dose-dependently attenuated BPA-induced
mitochondrial damage and improved sperm quality by preventing oxidative
stress.