BackgroundGaming Disorder is increasingly common in adolescents. We aimed to evaluate the relationship between parenting, personality traits, and Gaming Disorder.MethodsAn observational and cross-sectional study in six secondary schools of Castelló, obtaining a final sample of 397 students.ResultsAdolescents with Gaming Disorder had lower scores in Adolescent Affection-Communication (F= 8.201;p< 0.001), Father’s Warmth (F= 3.459;p= 0.028), and Father’s Acceptance/Involvement (F= 5.467;p= 0.003), and higher scores in Mother’s Revoking Privileges (F= 4.277;p= 0.034) and Father’s Indifference (F= 7.868;p= 0.002) than healthy participants. Male sex was a risk factor for Gaming Disorder (OR = 12.221;p= 0.004), while Adolescent Affection-Communication (OR = 0.908;p= 0.001) and Agreeableness (OR = 0.903;p= 0.022) were protective factors. Data modeling described the protective effect that Adolescent Affection-Communication had on Gaming Disorder, which was both directly (B= -0.20;p< 0.001) and indirectly mediated by Neuroticism (B= -0.20;p< 0.001), while Neuroticism itself was a risk factor for Gaming Disorder (B= 0.50;p< 0.001).ConclusionThese results reflect that Parental style with low affection and communication was directly and indirectly related to the Gaming Disorder, as well as male sex and personality trait of Neuroticism.