IntroductionUniversal single-shade composite resins are characterized by a property that enables the creation of restorations that mimic tooth structure to the extent possible with fewer shades of color.ObjectivesThis study aimed to instrumentally and visually evaluate the color correspondence of two single-shade composite resins in extracted human teeth multishade composite resins.MethodsUpper central incisors and upper and/or lower molars with intact buccal surfaces were selected. The study consisted of a control group (n= 20): Z250 XT (3M ESPE) (G1) multishade composite resin in colors A1 to A4, and a test group (n= 20) divided further into two equal groups, consisting of single-shade composite resin Omnichroma (Tokuyama Dental) (G2) and single-shade composite resin Vittra APS Unique from (FGM) (G3). Instrumental evaluation was performed using a spectrophotometer, and visual evaluation was performed by three observers. Descriptive measurements related to the differences in color obtained through instrumental means were analyzed using mean and standard deviation, wherein the means were compared using ANOVA, applying the Bonferroni post hoc test.ResultsA statistically significant difference was observed among the groups (G1, G2, and G3) (ANOVA:p< 0.001). For the visual assessment, regardless of the assessment group, 77.49% of the teeth were within the acceptable color-match classification, with the single-shade resins showing better correspondence than the multishade resins.ConclusionSingle-shade composite resins showed different color-matching results when compared to multishade resins, both in spectrophotometry and visual evaluations.Clinical Significance. Single-shade composite resins simplify the shade-selection process and are promising materials for use in dental practice.