Nanoporous gold (NPG) is characterized by a bicontinuous
network
of nanometer-sized metallic struts and interconnected pores formed
spontaneously by oxidative dissolution of the less noble element from
gold alloys. The resulting material exhibits decent catalytic activity
for low-temperature, aerobic total as well as partial oxidation reactions,
the oxidative coupling of methanol to methyl formate being the prototypical
example. This review not only provides a critical discussion of ways
to tune the morphology and composition of this material and its implication
for catalysis and electrocatalysis, but will also exemplarily review
the current mechanistic understanding of the partial oxidation of
methanol using information from quantum chemical studies, model studies
on single-crystal surfaces, gas phase catalysis, aerobic liquid phase
oxidation, and electrocatalysis. In this respect, a particular focus
will be on mechanistic aspects not well understood, yet. Apart from
the mechanistic aspects of catalysis, best practice examples with
respect to material preparation and characterization will be discussed.
These can improve the reproducibility of the materials property such
as the catalytic activity and selectivity as well as the scope of
reactions being identified as the main challenges for a broader application
of NPG in target-oriented organic synthesis.