This Editorial highlights some current challenges and emerging solutions in wearable sensors, a maturing field where interdisciplinary crosstalk is of paramount importance. Currently, investigation efforts are aimed at expanding the application scenarios and at translating early developments from basic research to widespread adoption in personal health monitoring for diagnostic and therapeutic purposes. This translation requires addressing several old and new challenges that are summarized in this editorial. The special issue “Emerging technologies in wearable sensors” includes four selected contributions from leading researchers, exploring the topic from different perspectives. The aim is to provide theAPL Bioengineeringreaders with a solid and timely overall vision of the field and with some recent examples of wearable sensors, exploring new research avenues.