This study utilized both experimental testing and machine learning (ML) strategies to assess the effectiveness of waste glass powder (WGP) on the compressive strength (CS) of cement mortar. The cement-to-sand ratio was kept 1:1 with a water-to-cement ratio of 0.25. The superplasticizer content was 4% by cement mass, and the proportion of silica fume was 15%, 20%, and 25% by cement mass in three different mixes. WGP was added to cement mortar at replacement contents from 0 to 15% for sand and cement with a 2.5% increment. Initially, using an experimental method, the CS of WGP-based cement mortar at the age of 28 days was calculated. The obtained data were then used to forecast the CS using ML techniques. For CS estimation, two ML approaches, namely decision tree and AdaBoost, were applied. The ML model's performance was assessed by calculating the coefficient of determination (R2), performing statistical tests and k-fold validation, and assessing the variance between the experimental and model outcomes. The use of WGP enhanced the CS of cement mortar, as noted from the experimental results. Maximum CS was attained by substituting 10% WGP for cement and 15% WGP for sand. The findings of the modeling techniques demonstrated that the decision tree had a reasonable level of accuracy, while the AdaBoost predicted the CS of WGP-based cement mortar with a higher level of accuracy. Utilizing ML approaches will benefit the construction industry by providing efficient and economic approaches for assessing the properties of materials.