Background:Salmonella entericais one of the most prevalent bacterial foodborne pathogens.Salmonellaphages are currently used in biocontrol applications and have potential for use as therapeutics.Materials and Methods:Phages were enriched and purified from a diversity ofSalmonellahost isolates. Morphology was determined with transmission electron microscopy, host ranges were characterized using an efficiency of plaquing assay, and comparative genomic analysis was performed to determine taxonomy.Results:Ten phages were isolated and characterized. Phages showed activity against 23 out of the 24Salmonellaserovars evaluated. Two phages also showed activity againstEscherichia colistrain B. Phages belonged to five different genera (Ithacavirus,Gelderlandvirus,Kuttervirus,Tlsvirus, andEpseptimavirus), two established species, and eight novel species.Conclusions:The phages described here further demonstrate the diversity ofS. entericaphages present in wastewater effluent. This work contributes a collection of characterized phages from eastern Tennessee that may be of use in future phage-based applications targetingS. enterica.