This study aimed to explore the mediating and moderating effects of resilience and perseverance on pilots’ self-efficacy and capability of handling special situations. Using cluster sampling, 251 pilots’ self-efficacy, special flight situation handling capability, resilience and perseverance were assessed using standardized scales. Pilots with high self-efficacy can improve their resilience to enhance their capability to handle special situations. An analysis was performed that included perseverance in the mediation model, and results showed that the influence of self-efficacy on special situation handling through resilience was moderated by perseverance. The relations between self-efficacy and special flight situation handling capability present a moderated mediation model. A pilot’s capability of handling special situations, ensuring flight safety and combat capability may be enhanced by improving their self-efficacy, resilience, and perseverance.