Along with the development and improvement of measuring technologies and techniques in recent times, new methods have appeared to model and monitor the behavior of land and constructions over time. The main purpose of this research was to develop a new methodology to model and monitor large buildings in a non-invasive way. The methods proposed in this research are non-destructive and can be used to monitor the behavior of buildings over time. A method of comparing point clouds obtained using terrestrial laser scanning combined with aerial photogrammetric methods was used in this study. The advantages and disadvantages of using non-destructive measurement techniques over the classic methods were also analyzed. With a building located in the University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca campus as a case study and with the help of the proposed methods, the deformations over time of the facades of that building were determined. As one of the main conclusions of this case study, it can be stated that the proposed methods are adequate to model and monitor the behavior of constructions over time, ensuring a satisfactory degree of precision and accuracy. The methodology can be successfully applied to other similar projects.