With advancements in technology able to quantify wide-ranging features of human movement, the aim of the present study was to investigate the inter-device technological reliability of a three-dimensional markerless motion capture system (3D-MCS), quantifying different movement tasks. A total of 20 healthy individuals performed a test battery consisting of 29 different movements, from which 214 different metrics were derived. Two 3D-MCS located in close proximity were utilized to quantify movement characteristics. Independent samplet-tests with selected reliability statistics (i.e., intraclass correlation coefficient (ICC), effect sizes, and mean absolute differences) were used to evaluate the agreement between the two systems. The study results suggested that 95.7% of all metrics analyzed revealed negligible or small between-device effect sizes. Further, 91.6% of all metrics analyzed showed moderate or better agreement when looking at the ICC values, while 32.2% of all metrics showed excellent agreement. For metrics measuring joint angles (198 metrics), the mean difference between systems was 2.9 degrees, while for metrics investigating distance measures (16 metrics; e.g., center of mass depth), the mean difference between systems was 0.62 cm. Caution is advised when trying to generalize the study findings beyond the specific technology and software used in this investigation. Given the technological reliability reported in this study, as well as the logistical and time-related limitations associated with marker-based motion capture systems, it may be suggested that 3D-MCS present practitioners with an opportunity to reliably and efficiently measure the movement characteristics of patients and athletes. This has implications for monitoring the health/performance of a broad range of populations.