Plant malectin/malectin-like receptor-like kinases (MRLKs) play crucial roles throughout the life course of plants. Here, we identified 23 SiMRLK genes from foxtail millet. All the SiMRLK genes were named according to the chromosomal distribution of theSiMRLKsin the foxtail millet genome and grouped into five subfamilies based on phylogenetic relationships and structural features. Synteny analysis indicated that gene duplication events may take part in the evolution of SiMRLK genes in foxtail millet. The expression profiles of 23 SiMRLK genes under abiotic stresses and hormonal applications were evaluated through qRT-PCR. The expression ofSiMRLK1,SiMRLK3,SiMRLK7andSiMRLK19were significantly affected by drought, salt and cold stresses. Exogenous ABA, SA, GA and MeJA also obviously changed the transcription levels ofSiMRLK1,SiMRLK3,SiMRLK7andSiMRLK19. These results signified that the transcriptional patterns ofSiMRLKsshowed diversity and complexity in response to abiotic stresses and hormonal applications in foxtail millet.