Uncontrolled use of antifungal drugs affects the development
of
resistance to existing drugs. Azole antifungals constitute a large
part of antifungal therapy. Therefore, there is a need for new azole
antifungals. Within the scope of this study, 17 new triazole derivative
compounds were synthesized. Structure determinations were clarified
by spectroscopic analysis methods (1H-NMR,13C-NMR, HRMS). In addition, structure matching was completed using
two-dimensional NMR techniques, HSQC, HMBC and NOESY. The antifungal
effects of the compounds were evaluated onCandidastrains by means ofin vitromethod. Compound5dshowed activity againstCandida glabratawith a MIC90= 2 μg/mL. Compound5dshowed activity againstCandida kruseiwith a MIC90= 2 μg/mL. This activity value, which
is higher than fluconazole, is promising. In addition, the biofilm
inhibition percentages of the compounds were calculated. Molecular
docking and molecular dynamics simulations performed with compound5dare in harmony with activity studies.