PurposeWe aim to determine whether kinematic chain dynamics of the hindfoot and lower leg are involved in the effect of a lateral wedge insole (LWI) on reducing lateral thrust among patients with medial compartment knee osteoarthritis (KOA).Participants and methodsEight patients with knee osteoarthritis were included in the study. Evaluation of the kinematic chain and gait analysis was performed using an inertial measurement unit (IMU). The dynamics of the kinematic chain were calculated as linear regression coefficients of the external rotation angle of the lower leg relative to the inversion angle of the hindfoot during repeated inversion and eversion of the foot in the standing position (kinematic chain ratio (KCR)). Walk tests were performed under four conditions: barefoot (BF), neutral insole (NI) with an incline of 0 degrees, and LWI with an incline of approximately 5 and 10 degrees (5LWI and 10LWI, respectively).ResultsThe mean (± standard deviation (SD)) KCR was 1.4 ± 0.5. The KCR was significantly correlated with the change in 5LWI lateral thrust acceleration relative to BF (r = 0.74). A significant correlation was also observed between changes in the hindfoot evolution angle and lower leg internal rotation angle with a 10LWI with respect to BF and NI, and changes in lateral thrust acceleration.ConclusionThe results of this study suggest that the kinematic chain is involved in the effects of an LWI in patients with knee osteoarthritis.