It is urgent to solve the gender issues in global cross-cultural communication. Countries worldwide should responsible for achieving gender equality (SDG5). Hence, the study aims to portray the knowledge map of the gender issue in intercultural communication to explore the research status and future potential. The study usedCiteSpaceto conduct a bibliometric method within 2728 English articles on cross-cultural communication and gender equality topics from theWeb of Science (WoS). After cluster analysis and time series analysis, this study emphasis the continued attention and increasing trend of publications and elaborates on the critical authors, institutions, and countries of research on this issue. The results introduced Putnick as the dominant author contributed to the topic. The University of Oxford ranked the top1 in the institution cooperation relationship. Europe countries and the United States have made major contributions and influenced Asian and African countries, such as Burkina Faso, North Macedonia, and Kosovo. Gender issues in Asia and Africa are getting much attention. The keyword clusters formed by the authors' cooperation include gender equality, life satisfaction, network analysis, and alcohol use. In addition, childbirth technology, patient safety competition, life satisfaction, capital safety, and sex difference are the key word clustering results of institutional cooperation. At the level of national cooperation, internet addition, risk sexual behavior, covid-19 pandemic and suicidal idea have become the main keywords The results of keyword cluster analysis show that gender role attribute, psychological properties, dating policy, professional fulfillment, and entrepreneurial intention have become the main topics in the current research. The research frontier analysis reflects the importance of gender, women and health. The research on self-efficacy, diversity, image, life satisfaction and choice has become the trend of cross-cultural communication and gender issues. Furthermore, abundant achievement emerged in the subjects of Psychology, Education, Sociology, and Business economics. Geography, Language and Literature, Medicine, and Health industries also have been highly influential in recent years. Therefore, the conclusion suggests the studies of gender issues can be further deepened into more authors, areas, subject and other multiple cooperation sectors.