Synthetic biology (SynBio) has attracted like no other
recent development
the attention not only of Life Science researchers and engineers but
also of intellectuals, technology think-tanks, and private and public
investors. This is largely due to its promise to propel biotechnology
beyond its traditional realms in medicine, agriculture, and environment
toward new territories historically dominated by the chemical and
manufacturing industries—but now claimed to be amenable to
completebiologization. For this to happen, it is
crucial for the field to remain true to its foundational engineering
drive, which relies on mathematics and quantitative tools to construct
practical solutions to real-world problems. This article highlights
several SynBio themes that, in our view, come with somewhat precarious
promises that need to be tackled. First, SynBio must critically examine
whether enough basic information is available to enable the design
or redesign of life processes and turn biology from a descriptive
science into a prescriptive one. Second, unlike circuit boards, cells
are built with soft matter and possess inherent abilities to mutate
and evolve, even without external cues. Third, the field cannot be
presented as the one technical solution to many grave world problems
and so must avoid exaggerated claims and hype. Finally, SynBio should
pay heed to public sensitivities and involve social science in its
development and growth, and thus change the technology narrative from
sheer domination of the living world to conversation and win-win partnership.