A rock mass is a system of various scale blocks embodied into one another. Inter-block layers are usually composed of weaker and fissured rocks. On the action of dynamic-static loads, it can induce slip instability between blocks. In this paper, the slip instability laws of block rock masses are studied. Based on theory and calculation analysis finding that the friction force between rock blocks varies with block vibration and the friction between rock blocks can drop sharply, resulting in slip instability. The critical thrust and occurrence time of block rock masses slip instability are proposed. The factors affecting block slipping instability are analyzed. This study has significance to the rock burst mechanism induced by slip instability of rock masses.