IntroductionTuberculosis (TB) is caused byM. tuberculosiscomplex (MTB) and pulmonary tuberculosis (PTB) is its classical manifestation. However, in some regions of the world, extrapulmonary TB (EPTB) seems to be more frequent.MethodsWe performed a retrospective cohort study of all TB patients treated at University Hospital Frankfurt, Germany, for the time period 2013–2018. Patient charts were reviewed and demographic, clinical, and microbiological data recorded. Patients were subdivided according to their geographic origins.ResultsOf the 378 included patients, 309 were born outside Germany (81.7%). Three WHO regions were significantly associated with the occurrence of isolated EPTB: the South-East Asian Region (OR 3.37, CI 1.74–6.66,p< 0.001), the African Region (2.20, CI 1.25–3.90,p= 0.006), and the Eastern Mediterranean Region (OR 3.18, CI 1.78–5.76,p< 0.001). On a country level, seven countries of origin could be demonstrated to be significantly associated with the occurrence of isolated EPTB: India (OR 5.58, CI 2.30–14.20,p< 0.001), Nepal (OR 12.75, CI 1.73–259.28,p= 0.027), Afghanistan (OR 3.64, CI 1.14–11.98,p= 0.029), Pakistan (OR 3.64, CI 1.14–11.98,p= 0.029), Eritrea (OR 3.32, CI 1.52–7.47,p= 0.003), Somalia (OR 7.08, CI 2.77–19.43,p< 0.001), and Turkey (OR 9.56, CI 2.52–47.19,p= 0.002).ConclusionGeographical origin is a predictor for the occurrence of extrapulmonary TB. This might be linked to a delay in diagnosis in these patients, as well as specific responsible impairments of the host’s immune system, possible virulence factors of MTB, and relevant comorbidities.Supplementary InformationThe online version contains supplementary material available at 10.1007/s15010-022-01921-9.