Vapor drift of applied pesticides is an increasing concern. Among the major crops cultivated in the Lower Mississippi Delta (LMD), cotton receives most of the pesticides. An investigation was carried out to determine the likely changes in pesticide vapor drift (PVD) as a result of climate change that occurred during the cotton growing season in LMD. This will help to better understand the consequences and prepare for the future climate. Pesticide vapor drift is a two-step process: (a) volatilization of the applied pesticide to vapors and (b) mixing of the vapors with the atmosphere and their transport in the downwind direction. This study dealt with the volatilization part alone. Daily values of maximum and minimum air temperature, averages of relative humidity, wind speed, wet bulb depression and vapor pressure deficit for 56 years from 1959 to 2014 were used for the trend analysis. Wet bulb depression (WBD), indicative of evaporation potential, and vapor pressure deficit (VPD), indicative of the capacity of atmospheric air to accept vapors, were estimated using air temperature and relative humidity (RH). The calendar year weather dataset was trimmed to the cotton growing season based on the results of a precalibrated RZWQM for LMD. The modified Mann Kendall test, Pettitt test and Sen’s slope were included in the trend analysis suite using ‘R’. The likely changes in volatilization/PVD under climate change were estimated as (a) average qualitative change in PVD for the entire growing season and (b) quantitative changes in PVD at different pesticide application periods during the cotton growing season. Our analysis showed marginal to moderate increases in PVD during most parts of the cotton growing season as a result of climate change patterns of air temperature and RH during the cotton growing season in LMD. Estimated increased volatilization of the postemergent herbicide S-metolachlor application during the middle of July appears to be a concern in the last 20 years that exhibits climate alteration.