Organochlorine pesticides (OCPs) have been used extensively as insecticides and herbicides. This study investigates the occurrence of lindane in surface water from the Peshawar valley (i.e., Peshawar, Charsadda, Nowshera, Mardan and Swabi districts of Khyber Pakhtunkhwa, Pakistan). Out of 75 samples tested (i.e., 15 samples from each district), 13 samples (including 2 from Peshawar, 3 from Charsadda, 4 from Nowshera, 1 from Mardan, and 3 from Swabi) are found to be contaminated with lindane. Overall, the detection frequency is 17.3%. The maximum concentration of lindane is detected in a water sample from Nowshera and found to be 2.60 μg L−1. Furthermore, the degradation of lindane in the water sample from Nowshera, containing the maximum concentration, is investigated by simulated solar-light/TiO2(solar/TiO2), solar/H2O2/TiO2and solar/persulfate/TiO2photocatalysis. The degradation of lindane by solar/TiO2photocatalysis is 25.77% after 10 h of irradiation. The efficiency of the solar/TiO2process is significantly increased in the presence of 500 μM H2O2and 500 μM persulfate (PS) (separately), represented by 93.85 and 100.00% lindane removal, respectively. The degradation efficiency of lindane is lower in natural water samples as compared to Milli-Q water, attributed to water matrix effect. Moreover, the identification of degradation products (DPs) shows that lindane follows similar degradation pathways in natural water samples as the one in Milli-Q water. The results show that the occurrence of lindane in surface waters of Peshawar valley is a matter of great concern for human beings and the environment. Interestingly, H2O2and PS assisted solar/TiO2photocatalysis is an effective method for the removal of lindane from natural water.