Amphotericin B is the currently recommended therapy forMalasseziainvasive infection (MII), but this drug requires intravenous administration and is associated with significant toxicity. The role of broad-spectrum azoles in managing MII is not clear. We describe two cases of MII due toM. pachydermatisandM. furfurthat were successfully treated with posaconazole and reviewed the literature to assess the position of posaconazole in treating MII.