Highlights•Half of regular/daily cocaine users knowingly used opioids in the prior 30 days.•1 in 4 regular/daily opioid users knowingly used cocaine in the prior 30 days.•Use of opioid and cocaine was 6x as common in those with psychological distress.•Use of opioid and cocaine more common: never married, unemployed, large metro area.•Use of opioid and cocaine was half as common in people with post-HS education.