The deep sea is known to host novel bacteria with the potential to produce a diverse array of undiscovered natural products. Thus, understanding these bacteria is of broad interest in ecology and could also underpin applied drug discovery, specifically in the area of antimicrobials. Here, we isolate a new strain ofStreptomycesfrom the tissue of the deep-sea spongePolymastia corticatacollected at a depth of 1869 m from the Gramberg Seamount in the Atlantic Ocean. This strain, which was given the initial designation A15ISP2-DRY2T, has a genome size of 9.29 Mb with a G+C content of 70.83 mol%. Phylogenomics determined that A15ISP2-DRY2Trepresents a novel species within the genusStreptomycesas part of theStreptomyces aurantiacusclade. The biosynthetic potential of A15ISP2-DRY2Twas assessed relative to other members of theS.aurantiacusclade via comparative gene cluster family (GCF) analysis. This revealed a clear congruent relationship between phylogeny and GCF content. A15ISP2-DRY2Tcontains six unique GCFs absent elsewhere in the clade. Culture-based assays were used to demonstrate the antibacterial activity of A15ISP2-DRY2Tagainst two drug-resistant human pathogens. Thus, we determine A15ISP2-DRY2Tto be a novel bacterial species with considerable biosynthetic potential and propose the systematic name 'Streptomyces ortus'sp. nov.