Introduction:A descemetocele is a rare type of keratopathy that occurs when an intact descemet’s membrane of the eye undergoes a herniation through an overlying stroma. Previous literature has documented corneal damage via bacterial enzymes, especially, Pseudomonas and Neisseria species. Most recent prospective interventional studies showed treatment of these infections.Case presentation:This report presents the first instance of a methicillin-resistantStaphylococcus aureusdescemetocele presentation in a 51-year-old African American male, with co-presenting hypopyon sequelae successfully managed conservatively in an intensive care unit setting.Clinical discussion:An instance of a methicillin-resistantStaphylococcus aureushas not yet been documented in the literature. Likewise, a co-presentation with a hypopyon, which is known as a formation of inflammatory debris rich in white blood cells has not been studied.Conclusion:The presence of a hypopyon in the instances of bacterial descemetocele herniation should be further evaluated to see if there are associations with conservative, nonsurgical intervention outcomes.