Key PointsQuestionWhat are the sociodemographic characteristics, mental and physical health conditions, and family separation experiences of Yazidi refugees who resettled in Canada?FindingsIn this cross-sectional study of 242 Yazidi refugees who survived genocide and received care at a specialized Canadian refugee clinic, 51.2% were directly exposed to Daesh captivity, torture, or violence, and 95.2% experienced family separations. Yazidi refugees presented with physical symptoms and signs (49.1%), nutritional diseases (37.4%), mental and behavioral disorders (33.5%), and infectious and parasitic diseases (31.3%), and expert refugee clinicians suspected nearly one-half (48.3%) of refugees had somatoform disorders.MeaningThese findings suggest that resettled Yazidi refugees are highly traumatized, have clinically complex health conditions, and require holistic care that attends to both mental and physical health.