Key PointsQuestionWhat is the severity of injuries associated with electric scooters (e-scooters) compared with motorbikes or bicycles?FindingsIn this cohort study of 5233 patients referred in a major trauma center, injuries due to e-scooters were as severe as those due to bicycle or motorbike crashes. The mortality associated with e-scooter road traffic crashes was 9.2%, compared with 10.0% for bicycles and 5.2% for motorbikes.MeaningThe findings of this study may inform health care professionals of the specificities of major trauma related to e-scooters and inform future e-scooter regulation decisions worldwide.