ABSTRACTIn equatorial Brazil, the association of Burkitt lymphoma and Epstein–Barr virus manifests at high rates. Here, we report, for the first time, amplifications of aurora kinase genes (AURKA/B) in a patient with a history of periodontal abscess and the presence of a remaining nodule, diagnosed with Burkitt lymphoma and Epstein–Barr virus, and /HIV positive. The patient was a 38-year-old man who presented with a 2-week-old severe jaw pain and a 3-day-old severe bilateral headache. He had a history of human papilloma virus. Interphase FISH analysis showedAURKAandAURKBamplification. The patient’s condition worsened, progressing to death a month after the initial care. Changes in theMYCCandAURKApathways are directly associated with genomic instability. Thus,MYCCrearrangements and higher expression ofAURKA/Bmay be associated with therapy resistance, highlighting the importance ofAURKA/Bevaluation in Burkitt lymphoma.