Halloysite nanotubes (HNTs) are clay minerals with a tubular structure that can be used for many different applications in place of carbon nanotubes. Indeed, HNTs display low/non-toxicity, are biocompatible, and can be easily prepared. Moreover, the aluminum and silica groups present on HNTs’ inner and outer surfaces facilitate the interaction with various functional agents, such as alkalis, organosilanes, polymers, surfactants, and nanomaterials. This allows the deposition of different materials, for instance, metal and non-metal oxides, on different substrate types. This review article first briefly presents HNTs’ general structure and the various applications described in the last 20 years (e.g., drug delivery, medical implants, and energy storage). Then, it discusses in detail HNT applications for water purification (inorganic and organic pollutants). It focuses particularly on HNT-TiO2composites that are considered very promising photocatalysts due to their high specific surface area and adsorption capacity, large pore volume, good stability, and mechanical features.