Alcohol and cigarettes are the psychoactive substances that adolescents use most frequently. When both addictions are combined, they carry the worst burden of disease globally. The objective of this study was to identify whether socioeconomic factors correlate with alcohol and tobacco consumption in Mexican adolescents aged 10 years or more and to establish the relationship in the consumption between the two substances. This ecological study utilized data describing alcohol and tobacco consumption among adolescents aged 10–16 years (n= 48,837 ≈N= 11,621,100). Having ever consumed any alcohol-containing beverage constituted alcohol consumption. Smoking a cigarette within 30 days constituted cigarette consumption. For both variables, the state-level percentages reported in the survey were used. Diverse socioeconomic variables were collected from official sources. Data on the prevalence of tobacco use and alcohol consumption were entered into an Excel database estimated for each of the states of the Mexican Republic, as well as the socioeconomic variables. We performed the analysis using Stata 14. Consumption prevalence was 15.0% for alcohol and 4.2% for tobacco. Alcohol consumption was not correlated with any studied socioeconomic variable (p> 0.05). The prevalence of tobacco consumption among elementary school students correlated (p< 0.05) with the portion of the population living in private dwellings without sewage, drainage, or sanitation (r= 0.3853). The prevalence of tobacco consumption among middle-school adolescents correlated with the portion of the employed population that earned up to two minimum wages (r= 0.3960), the percentage in poverty by income 2008 (r= 0.4754) and 2010 (r= 0.4531), and the percentage in extreme poverty by income 2008 (r= 0.4612) and 2010 (r= 0.4291). Positive correlations were found between tobacco consumption and alcohol consumption among both elementary (r= 0.5762,p=0.0006) and middle-school children (r= 0.7016,p=0.0000). These results suggest that certain socioeconomic factors correlate with tobacco consumption but not alcohol consumption. A correlation between alcohol consumption and tobacco consumption was observed. The results can be used for developing interventions in adolescents.