The finite element method was used to investigate the effect of the stress ratio on fatigue crack propagation behavior within the framework of the linear elastic fracture mechanics theory. The numerical analysis was carried out using ANSYS Mechanical R19.2 with the unstructured mesh method-based separating, morphing, and adaptive remeshing technologies (SMART). Mixed mode fatigue simulations were performed on a modified four-point bending specimen with a non-central hole. A diverse set of stress ratios (R= 0.1, 0.2, 0.3, 0.4, 0.5, −0.1, −0.2, −0.3, −0.4, −0.5), including positive and negative values, is employed to examine the influence of the load ratio on the behavior of the fatigue crack propagation, with particular emphasis on negativeRloadings that involve compressive excursions. A consistent decrease in the value of the equivalent stress intensity factor (ΔKeq) is observed as the stress ratio increases. The observation was made that the stress ratio significantly affects both the fatigue life and the distribution of von Mises stress. The results demonstrated a significant correlation between von Mises stress,ΔKeq, and fatigue life cycles. With an increase in the stress ratio, there was a significant decrease in the von Mises stress, accompanied by a rapid increase in the number of fatigue life cycles. The results obtained in this study have been validated by previously published literature on crack growth experiments and numerical simulations.