The construction of island airports on coral reefs inevitably encounters the impact load of aircraft takeoff and landing. However, previous studies have not presented a detailed description of the dynamic response of the coral sand beneath the runways of island reclamation airports under aircraft load. In the current study, the coral sand of Mischief Reef Airport in the Nansha Islands, China, was selected as the background. The pore water pressure and strain characteristics of reshaped coral sand under aircraft loads with different dynamic stress amplitudes and vibration frequencies were studied using dynamic triaxial tests. Particle discrete element software was employed to study the deformation characteristics of coral sand with different particle sizes and porosities under aircraft loads. Results show that when the dynamic stress amplitude and vibration frequency were small, the pore water pressure and strain of the coral sand samples gradually increased with the number of load cycles, and the growth rate became increasingly small. When the dynamic stress amplitude and vibration frequency were large, the axial strain of the coral sand samples increased with the vibration frequency, and the growth rate exhibited an increasing trend. The deformation of the coral sand samples increased with porosity under aircraft loading. The larger the variation range of the coral sand particle size was, the larger the coral sand deformation caused by aircraft takeoff and landing load was. These results can provide a reference for the treatment and repair of the airstrip foundation of island airports.