Ecdysone receptor (EcR) and chitinase play a critical role in the molting stage of insect pests. Each of them is considered a promising target for the development of novel insect growth regulators (IGRs). In the present paper, a total of 24 (23 novel) hexacyclic pyrazolamide derivatives were designed and synthesized by reducing the heptacycle and inserting small flexible linkers on the basis of the previously discovered dual-target compoundD-27acting simultaneously on EcR andOstrinia furnacalischitinase (OfChtI). Their insecticidal activities againstPlutella xylostella,Spodoptera frugiperda, andOstrinia furnacalislarvae were evaluated. The results revealed that the insecticidal activity was not significantly enhanced when the heptacycle on the pyrazole ring was reduced to a hexacycle. However, the insertion of an additional methylene spacer between the substituted phenyl ring and the amide bond can improve the insecticidal activity. Among the derivatives, the most potent compound,6j, exhibited promising insecticidal activities againstP. xylostellaandS. frugiperda. Further protein binding assays and molecular docking indicated that6jcould target both EcR andOfChtI, and is a potential lead compound for IGRs. The present work provides valuable clues for the development of new dual-target IGRs.