Key PointsQuestionWhat proportion of reproductive-age female individuals in a nonclinical setting carry uterine fibroids, and which racial and ethnic groups are most affected?FindingsIn this cross-sectional study of 996 reproductive-age female participants, the overall prevalence of fibroids was 20%. Black or African American (35.7%) and Asian-Chinese (21.8%) participants were disproportionately affected compared with White (10.7%) and Hispanic (12.7%) participants.MeaningThese findings suggest that health care professionals should be cognizant of the high prevalence of uterine fibroids, especially in Black or African American and Asian-Chinese groups, to facilitate timely diagnosis and reduce health disparities associated with this pathology.