Background: ChatGPT, created by OpenAI, is a large language model which has become the fastest growing consumer application in history, recognized for its expansive knowledge of varied subjects. The field of oncology is highly specialized and requires nuanced understanding of medications and conditions. Herein, we sought to better qualify the ability of ChatGPT to name applicable treatments for patients with advanced solid cancers.Methods: This observational study was conducted utilizing ChatGPT. The capacity of ChatGPT to tabulate appropriate systemic therapies for new diagnoses of advanced solid malignancies was ascertained through standardized prompts. A ratio of those medications listed by ChatGPT to those suggested in the National Comprehensive Cancer Network (NCCN) guidelines was produced and called the valid therapy quotient (VTQ). Additional descriptive analyses of the VTQ and its association with incidence and type of treatment were performed.Results: Some 51 distinct diagnoses were utilized within this experiment. ChatGPT was able to identify 91 distinct medications in response to prompts related to advanced solid tumors. The overall VTQ is 0.77. In all cases, ChatGPT was able to provide at least one example of systemic therapy suggested by the NCCN. There was a weak association between incidence of each malignancy and the VTQ.Conclusion: The capacity of ChatGPT to identify medications used to treat advanced solid tumors indicates a level of concordance with the NCCN guidelines. As it stands, the role of ChatGPT to assist oncologists and patients in treatment decision making remains unknown. Nonetheless, in future iterations, it may be anticipated that accuracy and consistency in this domain will improve, and further studies will be needed to better quantify its capabilities.