Background:Helicobacter pylori(H. pylori) has definite or possible associations with multiple local and distant manifestations.H. pylorihas been isolated from multiple sites throughout the body, including the nose. Clinical non-randomized studies withH. pylorireport discrepant data regarding the association betweenH. pyloriinfection and nasal polyps. The aim of this first systematic review and meta-analysis was the assessment of the strength of the association betweenH. pyloriinfection and incidence of nasal polyps. Methods: We performed an electronic search in the three major medical databases, namely PubMed, EMBASE and Cochrane, to extract and analyze data as per PRISMA guidelines. Results: Out of 57 articles, 12 studies were graded as good quality for analysis. Male-to-female ratio was 2:1, and age ranged between 17–78 years. The cumulative pooled rate ofH. pyloriinfection in the nasal polyp group was 32.3% (controls 17.8%). The comparison between the two groups revealed a more significant incidence ofH. pyloriinfection among the nasal polyp group (OR 4.12), though with high heterogeneity I2= 66%. Subgroup analysis demonstrated that in European studies, the prevalence ofH. pyloriinfection among the nasal polyp group was significantly higher than in controls, yielding null heterogeneity. Subgroup analysis based on immunohistochemistry resulted in null heterogeneity with preserving a statistically significant difference inH. pyloriinfection prevalence between the groups. Conclusion: The present study revealed a positive association betweenH. pyloriinfection and nasal polyps.