BackgroundAccurate classification based on affordable objective neuroimaging biomarkers are important steps toward designing individualized treatment.MethodsIn this work, we investigated a deep learning classification model, multi-scale convolutional recurrent neural network (MCRNN), to explore psychiatric disorder-related biomarkers by leveraging the spatiotemporal information of resting-state EEG (rsEEG) using a multiple psychiatric disorder database containing 327 individuals diagnosed with schizophrenia, bipolar, major depressive disorders, and healthy controls. All subjects were mapped to a shared low-dimensional subspace for intuitively interpreting the inter-relationship and separation of psychiatric disorders.ResultsPsychiatric disorders were identified using rsEEG with high accuracy ranged from 78.6 to 91.3% in patient vs. controls two-class classification, and 68.2% in four-class classification. The control-to-schizophrenia trajectory interpretated by the model was consistent with the disease severity in clinical observation.ConclusionThe MsRNN demonstrated a capability in extracting discriminative rsEEG biomarkers for psychiatric disorder classification, indicating its potential to facilitate our understanding of psychiatric disorders and monitoring interventions.