AbstractBackground and AimPolio eradication efforts including polio‐philanthropy have been coordinated and sustained since 1988, with the introduction of the Global Polio Eradication Initiative (GPEI). The polio fight is sustained in the name of evidence‐based benevolence or beneficent philanthropy from which Africa has benefited immensely. With the recorded polio cases as of 2023, more efforts and funds are required to eradicate polio. Hence, it is not yet “Uhuru.” Using the Mertonian lens, this study examines polio‐philanthropy in Africa, its unintended consequences, and crucial dilemmas, which could impact the polio fight and polio‐philanthropy.MethodsThis is a narrative review that relies on secondary sources obtained through a thorough literature search. Only studies published in English were utilized. The study synthesized relevant literature in line with the study objective. The following databases were consulted: PubMed, philosopher's index, web of knowledge, Google Scholar, and Sociological Abstracts. Both empirical and theoretical studies were utilized for the study.ResultsDespite significant achievements, the global initiative has shortcomings when examined through the Mertonian lens of manifest and latent functions. The GPEI sets a unilinear goal within multiple challenges. The activities of the philanthropic giants manifest in disempowering rigor, multisectoral neglect, and parallel (health) systems, sometimes, inimical to the national health system. Most philanthropic giants often operate vertically. It is observed that, apart from funding, the last phase of polio‐philanthropy will be defined by some crucial factors, the 4Cs: Communicable disease outbreaks, Conflict, Climate‐related disasters, and Conspiracy theory, which could impact the prevalence or resurgence of polio.ConclusionThe polio fight will benefit from the persistent drive to reach the finish line as scheduled. The latent consequences or dysfunctions are general lessons for GPEI and other global health initiatives. Therefore, decision‐makers should calculate the net balance of consequences within global health philanthropy for appropriate mitigation.