BackgroundPediatric research is crucial for the development of new scientific advancements, treatments, and therapies for adolescents. Yet relatively few pediatric clinical trials are conducted due to barriers to successful recruitment and retention, including knowledge and attitudes about clinical trials. Adolescents tend to experience greater autonomy to make decisions and have expressed interest in being part of the decision to participate in clinical trials. Increasing knowledge, positive attitudes, and self-efficacy related to clinical trials could positively impact the decision to participate in a pediatric clinical trial. However, there are currently few interactive, developmentally appropriate, web-based resources available to educate adolescents about clinical trials.DigiKnowItNews: Teenwas created as a multimedia educational website to address the relatively low levels of enrollment in pediatric clinical trials and need for information to empower adolescents to make decisions about participating in clinical trials.MethodsThis is a parallel group randomized controlled superiority trial to test the effectiveness ofDigiKnowItNews: Teen, for improving factors related to clinical trial participation among adolescent and parents. Eligible parent-adolescent (ages 12 to 17 years) pairs will be randomly assigned to one of two conditions: intervention or wait-list control. All participants will complete pre- and post-test questionnaires and participants assigned to the intervention will receive access to review theDigiKnowItNews: Teencontent for 1 week. Wait-list control participants will have the option to reviewDigiKnowItNews: Teenafter study completion. The primary outcomes are knowledge about clinical research, attitudes, and beliefs toward pediatric clinical trials, self-efficacy for making decisions related to clinical trial participation, willingness to participate in a future clinical trial, procedural fears, and parent-adolescent communication quality. Overall feedback and satisfaction related toDigiKnowItNews: Teenwill also be collected.DiscussionThe trial will evaluate the effectiveness ofDigiKnowIt News: Teen, an educational website about pediatric clinical trials for adolescents. If found effective in promoting factors related to future pediatric clinical trial participation,DigiKnowIt News: Teencould be used by adolescents, along with their parents, as they make the decision to participate in a clinical trial. Clinical trial researchers can also useDigiKnowIt News: Teento aid their participant recruitment efforts.Trial registrationClinicalTrials.gov NCT05714943. Registered on 02/03/2023.