Key PointsQuestionIs homelessness associated with hospital admission following injury?FindingsIn this national cohort study of 12 266 people experiencing homelessness (PEH) from the American College of Surgeons Trauma Quality Improvement Program, PEH demonstrated significantly increased adjusted odds of hospital admission after injury compared with housed patients.MeaningThese findings suggest that potential challenges in facilitating safe discharge from the emergency department may lead to increased hospital admission after injury for PEH.