BackgroundA denture adhesive for dry mouth with good cleaning properties has recently been developed. While previous studies on models have shown the effectiveness of denture adhesives in terms of retention and cleanability, no reports have evaluated their effectiveness in the oral cavity. The aim of this study was to compare and investigate the retention and usability of an experimental palatal plate in the dentulous jaw using a denture adhesive for dry mouth, a conventional cream-type denture adhesive, an oral moisturizer, and a denture moisturizer.MethodsTen healthy dentulous participants (mean age 27.2 ± 1.6 years) were included in the study. Palatal plates were fabricated. Four test samples were used: denture adhesive for dry mouth, conventional denture adhesive (cream type), oral moisturizer, and denture moisturizer. The sample was applied to the inner surface of the palatal plates, and the retentive force of the palatal plate was measured every 10 min for 30 min. After the measurements, the study participants were asked to rinse the palatal plate with water and subjectively evaluate the samples used.ResultsThe conventional denture adhesive (cream type) showed increased retentive force over time, with the maximum retentive force obtained after 10 min of application. However, its washability was rated second lowest. The denture adhesive for dry mouth showed the highest retentive force immediately after application. Its washability was also good.ConclusionsThe results suggest that the denture adhesive for dry mouth has reasonable retentive force in the oral cavity and cleaning properties compared to the conventional cream-type denture adhesive.