Hybrid nanofluids may exhibit higher thermal conductivity, chemical stability, mechanical resistance and physical strength compared to regular nanofluids. Our aim in this study is to investigate the flow of a water-based alumina-copper hybrid nanofluid in an inclined cylinder with the impact of buoyancy force and a magnetic field. The governing partial differential equations (PDEs) are transformed into a set of similarity ordinary differential equations (ODEs) using a dimensionless set of variables, and then solved numerically using the bvp4c package from MATLAB software. Two solutions exist for both buoyancy opposing (λ < 0) and assisting (λ > 0) flows, whereas a unique solution is found when the buoyancy force is absent (λ = 0). In addition, the impacts of the dimensionless parameters, such as curvature parameter, volume fraction of nanoparticles, inclination angle, mixed convention parameter, and magnetic parameter are analyzed. The results of this study compare well with previously published results. Compared to pure base fluid and regular nanofluid, hybrid nanofluid reduces drag and transfers heat more efficiently.