TheWRKYgene family plays important roles in plant growth and development, as well as in the responses to biotic and abiotic stresses.Loropetalum chinensevar.rubrumhas high ornamental and medicinal value. However, fewWRKYgenes have been reported in this plant, and their functions remain unknown. To explore the roles that theWRKYgenes play inL. chinensevar.rubrum, we identified and characterized 79LcWRKYsthrough BLAST homology analysis and renamed them (asLcWRKY1–79) based on their distribution on the chromosomes ofL. chinensevar.rubrum. In this way, according to their structural characteristics and phylogenetic analysis, they were divided into three groups containing 16 (Group I), 52 (Group II), and 11 (Group III) WRKYs, respectively. LcWRKYs in the same group have similar motifs and gene structures; for instance, Motifs 1, 2, 3, 4, and 10 constitute the WRKY domain and zinc-finger structure. TheLcWRKYpromoter region contains light response elements (ACE, G-box), stress response elements (TC-rich repeats), hormone response elements (TATC-box, TCA-element), and MYB binding sites (MBS, MBSI). Synteny analysis ofLcWRKYsallowed us to establish orthologous relationships among theWRKYgene families ofArabidopsis thaliana,Oryza sativa,Solanum lycopersicumL.,Vitis viniferaL.,Oryza sativaL., andZea maysL.; furthermore, analysis of the transcriptomes of mature leaves and flowers from different cultivars demonstrated the cultivar-specificLcWRKYgene expression. The expression levels of certainLcWRKYgenes also presented responsive changes from young to mature leaves, based on an analysis of the transcriptome in leaves at different developmental stages. White light treatment led to a significant decrease in the expression ofLcWRKY6, 18, 24, 34, 36, 44, 48, 61, 62,and77and a significant increase in the expression ofLcWRKY41, blue light treatment led to a significant decrease in the expression ofLcWRKY18, 34, 50,and77and a significant increase in the expression ofLcWRKY36and48. These results enable a better understanding ofLcWRKYs, facilitating the further exploration of their genetic functions and the molecular breeding ofL. chinensevar.rubrum.