Coriaria nepalensisWall. (Coriariaceae) is a nitrogen-fixing shrub which forms root nodules with the actinomyceteFrankia. Oils and extracts ofC. nepalensishave been reported to be bacteriostatic and insecticidal, andC. nepalensisbark provides a valuable tannin resource. Here, by combining PacBio HiFi sequencing and Hi-C scaffolding techniques, we generated a haplotype-resolved chromosome-scale genome assembly forC. nepalensis. This genome assembly is approximately 620 Mb in size with a contig N50 of 11 Mb, with 99.9% of the total assembled sequences anchored to 40 pseudochromosomes. We predicted 60,862 protein-coding genes of which 99.5% were annotated from databases. We further identified 939 tRNAs, 7,297 rRNAs, and 982 ncRNAs. The chromosome-scale genome ofC. nepalensisis expected to be a significant resource for understanding the genetic basis of root nodulation withFrankia, toxicity, and tannin biosynthesis.