Diabetes is a widespread noncommunicable disease affecting millions of people globally, and it is accompanied by various complications ranging from minor to major. Among the complications, skin problems are highly prevalent in diabetic patients, including dry skin, itching, redness, scarring, and edema. Proper skin care is vital in preventing skin-related complications in diabetes. We conducted a comprehensive search of PubMed, Scopus, Google Scholar, and Web of Science databases for literature published from 2012 to 2022 using the following keywords: diabetes, diabetes prevalence, diabetes complications, skin problems in diabetes, and skin care protocols. Topical agents have been found effective in managing pruritus, xerosis, and other complications associated with diabetes. Skin care, especially foot care, is crucial in diabetes. Emollients and urea-based creams are commonly used for foot care. The review highlights the importance of following a skin care protocol to prevent skin-related complications in diabetes. Topical agents, emollients, and foot care are crucial in managing diabetic skin problems. Clinicians should ensure that patients with diabetes are educated about skin care's importance and provided with appropriate guidance to maintain healthy skin.