BackgroundExertional dyspnea and exercise intolerance are frequently endorsed in Veterans of post 9/11 conflicts in Southwest Asia (SWA). Studying the dynamic behavior of ventilation during exercise may provide mechanistic insight into these symptoms. Using maximal cardiopulmonary exercise testing (CPET) to experimentally induce exertional symptoms, we aimed to identify potential physiological differences between deployed Veterans and non-deployed controls.Materials and methodsDeployed (n = 31) and non-deployed (n = 17) participants performed a maximal effort CPET via the Bruce treadmill protocol. Indirect calorimetry and perceptual rating scales were used to measure rate of oxygen consumption (V˙O2), rate of carbon dioxide production (V˙CO2), respiratory frequency (fR), tidal volume (VT), minute ventilation (V˙E), heart rate (HR), perceived exertion (RPE; 6–20 scale), and dyspnea (Borg Breathlessness Scale; 0–10 scale). A repeated measures analysis of variance (RM-ANOVA) model (2 groups: deployed vs non-deployed X 6 timepoints: 0%, 20%, 40%, 60%, 80%, and 100%V˙O2peak) was conducted for participants meeting valid effort criteria (deployed = 25; non-deployed = 11).ResultsSignificant group (η2partial= 0.26) and interaction (η2partial= 0.10) effects were observed such that deployed Veterans exhibited reducedfRand a greater change over time relative to non-deployed controls. There was also a significant group effect for dyspnea ratings (η2partial= 0.18) showing higher values in deployed participants. Exploratory correlational analyses revealed significant associations between dyspnea ratings andfRat 80% (R2= 0.34) and 100% (R2= 0.17) ofV˙O2peak, but only in deployed Veterans.ConclusionRelative to non-deployed controls, Veterans deployed to SWA exhibited reducedfRand greater dyspnea during maximal exercise. Further, associations between these parameters occurred only in deployed Veterans. These findings support an association between SWA deployment and affected respiratory health, and also highlight the utility of CPET in the clinical evaluation of deployment-related dyspnea in Veterans.