With the increasing development of coiled tubing drilling technology, the advantages of coiled tubing drilling technology are becoming more and more obvious. In the operation process of coiled tubing, Due to various different drilling parameters, manufacturing defects, and improper human handling, the coiled tubing can curl up and cause stuck drilling or shortened service life problems. Circulation pressure, wellhead pressure, and total weight have an important influence on the working period of coiled tubing. For production safety, this paper predicts circulation pressure, ROP, wellhead pressure, and finger weight using GAN–LSTM after studying drilling engineering theory and analyzing a large amount of downhole data. Experimental results show that GAN–LSTM can predict the parameters of circulation pressure, wellhead pressure ROP and total weight to a certain extent. After much training, the accuracy is about 90%, which is about 17% higher than that of the GAN and LSTM. It has a certain guiding significance for coiled tubing operation, increasing operational safety and drilling efficiency, thus reducing production costs.