This study reports
an impact of structure (XRPD, FT-IR)
and surface
morphology (SEM-EDS) of imatinib-functionalized galactose hydrogels,
loaded and unloaded with nHAp, on osteosarcoma cell (Saos-2 and U-2OS)
viability, levels of free oxygen radicals, and nitric oxide, levels
of BCL-2, p53, and caspase 3 and 9, as well as glycoprotein-P activity.
It was investigated how the rough surface of the crystalline hydroxyapatite-modified
hydrogel affected amorphous imatinib (IM) release. The imatinib drug
effect on cell cultures has been demonstrated in different forms of
administration—directly to the culture or the hydrogels. Administration
of IM and hydrogel composites could be expected to reduce the risk
of multidrug resistance development by inhibiting Pgp.