BackgroundBacterial meningitis caused by non-typhoidSalmonellacan be a fatal condition which is more common in low and middle-income countries.Case presentationWe report the case of aSalmonellameningitis in a Belgian six-month old male infant. The first clinical examination was reassuring, but after a few hours, his general state deteriorated. A blood test and a lumbar puncture were therefore performed. The cerebrospinal fluid analysis was compatible with a bacterial meningitis which was later identified by the NRC (National Reference Center) asSalmonella entericaserovar Durban.ConclusionsIn this paper, we present the clinical presentation, genomic typing, and probable sources of infection for an unusually rare serovar ofSalmonella. Through an extended genomic analysis, we established its relationship to historical cases with links to Guinea.