Introduction: Assessing vital sign measurements within hospital settings presents a valuable opportunity for data analysis and knowledge extraction. By generating adaptable, personalized prediction models of patient vital signs, these models can yield clinically relevant insights not achievable through population-based models. This study aims to compare several statistical forecasting models to determine their real-life applicability.Objectives: The primary objectives of this paper are to evaluate whether the following measurements: blood pressure, oxygen saturation, temperature and heart rate can predict deterioration in Intensive Care Unit (ICU) patients. Additionally, we aim to identify which of these measurements contributes most significantly to our prediction. Lastly, we seek to determine the most accurate data mining technique for real-life data applications.Methods: This retrospective chart review study utilized data from patients admitted to the ICU at a tertiary hospital between January and December, 2019. Data mining techniques for prediction included logistic regression, support vector machine classifier, k-nearest neighbors (KNN), gradient boosting classifier, and Naive Bayes classifier. A comprehensive comparison of these techniques was performed, focusing on accuracy, precision, recall, and F-measure.Results: To achieve the research objectives, the SelectKBest class was applied to extract the most contributory features for prediction. Blood pressure ranked first with a score of 9.98, followed by respiratory rate, temperature, and heart rate. Analysis of 653 patient records indicated that 129 patients expired, while 542 patients were discharged either to their homes or other facilities. Among the five training models, two demonstrated the highest accuracy in predicting patient deterioration or survival at 88.83% and 84.72%, respectively. The gradient boosting classifier accurately predicted 115 out of 129 expired patients, while the KNN correctly predicted 109 out of 129 expired patients.Conclusion: Machine learning has the potential to enhance clinical deterioration prediction compared to traditional methods. This allows healthcare professionals to implement preventative measures and improve patients' quality of life, ultimately increasing average life expectancy. Although our research focused exclusively on ICU patients, data mining techniques can be applied in various contexts both within and outside the hospital setting.