This study aimed to evaluate the concentration of metals such as aluminum (Al), cadmium (Cd), lead (Pb), barium (Ba), bismuth (Bi), cobalt (Co), nickel (Ni), chromium (Cr), iron (Fe), copper (Cu), zinc (Zn), and selenium (Se) in 360 samples of poultry meat and liver from six brands (A, B, C, D, E, and F) in Assiut, Egypt; compare these concentrations with Egyptian and world permissible limits; and determine their safety for human consumption according to health risk assessment. Chest, thigh muscles, and liver were collected randomly from Assiut city markets, and the concentration of heavy metals was measured in the central laboratory of the faculty of agriculture at Assiut University using inductively coupled plasma mass spectrometry (ICP-MS). All the analyzed samples were positive for the tested metals and were far below the allowed maximum permissible limits except for Pb and Fe, which exceeded the Egyptian Organization for Standardization (EOS) permissible limits with 33% and 67%, respectively, as well as Pb and Cd, which exceeded FAO/WHO permissible limits with 94% and 17%, respectively. Health risk assessment revealed the safety and minimum health risk for human consumption of metal residues in poultry tissues and liver using estimated daily intake (EDI), target hazard quotient (THQ), hazard index (HI), and target cancer risk (TR). Even though the THQ and HI values were significantly lower than 1.0 during our study, heavy metal monitoring in poultry products and byproducts is required for human security and safety.