This study aims at computing the pooled mean estimate (PME) and health risks of heavy metals in seafood obtained from the Niger Delta Region of Nigeria (NDRN), using data from existing literatures. Pubmed, Scopus and Google Scholar were searched to retrieve articles that investigated the heavy metal contents of edible seafood from the NDRN. Search hits were screened against predetermined criteria following which relevant data were extracted from eligible articles. The PME for each metal was computed by performing a maximum likelihood random effect model meta-analysis using the R Studio Software. Outcome from the meta-analysis involving 58 studies and a total of 2983 seafood samples revealed the following PMEs (mg/kg dry wt seafood) for the investigated heavy metals: As (0.777), Cd (0.985), Co (4.039), Cr (2.26), Cu (11.45), Fe (143.39), Hg (0.0058), Mn (13.56), Ni (5.26), Pb (4.35), and Zn (29.32). The health risk assessment suggests that seafood from this region poses considerable carcinogenic and non-carcinogenic risks to human consumers. Our finding calls for urgent actions aimed at identifying and eliminating point sources of heavy metals pollution of the NDRN marine environment. Inhabitants of NDRN are encouraged to reduce seafood consumption while diversifying their protein sources to include non-seafood options.