This paper presents the results of an experimental study on the heat transfer and pressure drop characteristics of a novel spiral plate mini-channel gas cooler designed for use with supercritical CO2. The CO2channel of the mini-channel spiral plate gas cooler has a circular spiral cross-section with a radius of 1 mm, while the water channel has an elliptical cross-section spiral channel with a long axis of 2.5 mm and a short axis of 1.3 mm. The results show that increasing the mass flux of CO2can effectively enhance the overall heat transfer coefficient when the water side mass flow rate is 0.175 kg·s−1and the CO2side pressure is 7.9 MPa. Increasing the inlet water temperature can also improve the overall heat transfer coefficient. The overall heat transfer coefficient is higher when the gas cooler is vertically oriented compared to horizontally oriented. A Matlab program was developed to verify that the correlation based on Zhang’s method has the highest accuracy. The study found a suitable heat transfer correlation for the new spiral plate mini-channel gas cooler through experimental research, which can provide a reference for future designs.