Key PointsQuestionWhat is the association between fragmented readmissions (ie, readmission to a different hospital than patient was discharged from) and health information exchange (HIE) and discharge destination?FindingsIn this cohort study of 275 189 admission-readmission pairs of Medicare beneficiaries, fragmented readmissions were associated with a 10% higher odds of discharge to a skilled nursing facility and a 22% lower odds of discharge home with home health vs nonfragmented readmissions. In fragmented readmissions with shared HIE, beneficiaries had 9% to 15% higher odds of discharge home with home health vs fragmented readmissions in which information sharing was not available.MeaningThese findings indicate that fragmented readmissions may be associated with less favorable discharge destinations; however, HIE may mitigate information discontinuity present in fragmented readmissions.