Grape production worldwide is increasingly threatened by grapevine trunk diseases (GTDs). No grapevine cultivar is known to be entirely resistant to GTDs, but susceptibility varies greatly. To quantify these differences, four Hungarian grape germplasm collections containing 305 different cultivars were surveyed to determine the ratios of GTDs based on symptom expression and the proportion of plant loss within all GTD symptoms. The cultivars of monophyleticVitis viniferaL. origin were amongst the most sensitive ones, and their sensitivity was significantly (p< 0.01) higher than that of the interspecific (hybrid) cultivars assessed, which are defined by the presence ofVitisspecies other thanV. vinifera(e.g.,V. labruscaL.,V. rupestrisScheele, andV. amurensisRupr.) in their pedigree. We conclude that the ancestral diversity of grapes confers a higher degree of resilience against GTDs.