Background:Extensive studies on the link between single nucleotide polymorphisms (SNPs) in vascular endothelial growth factor (VEGF) and various malignancy risks produced conflicting results, notably for VEGF-460(T/C). To evaluate this correlation more comprehensively and accurately, we perform a meta-analysis.Methods:Through retrieving 5 databases (Web of Science (WoS), Embase, Pubmed, Wanfang database (Wangfang), and China National Knowledge Infrastructure (CNKI)) and applying hand search, citation search, and gray literature search, 44 papers included 46 reports were enrolled. To evaluate the relationship between VEGF-460 and cancer risk, we pooled odds ratios (ORs) and 95% confidence intervals (CIs).Results:Our results indicated that the VEGF-460 polymorphism is not related to malignancy susceptibility (dominant model, OR = 0.98, 95% CI = 0.87–1.09; recessive model, OR = 0.95, 95% CI = 0.82–1.10; heterozygous model, OR = 0.99, 95% CI = 0.90–1.10; homozygous model, OR = 0.92, 95% CI = 0.76–1.10; additive model, OR = 0.98, 95% CI = 0.90–1.07). While, in subgroup analysis, this SNP may reduce the risk of hepatocellular carcinoma.Conclusion:this meta-analysis indicated that VEGF-460 was irrelevant to overall malignancy risk, but it might be a protective factor for hepatocellular carcinoma.