Many theoretical models of iron-based superconductors (IBSC) have been proposed, but the superconducting transition temperature (Tc) calculations based on these models are usually missing. We have chosen two models of iron-based superconductors from the literature and computed theTcvalues accordingly; recently two models have been announced which suggest that the superconducting electron concentration involved in the pairing mechanism of iron-based superconductors may have been underestimated and that the antiferromagnetism and the inducedxypotential may even have a dramatic amplification effect on electron–phonon coupling. We use bulk FeSe, LiFeAs and NaFeAs data to calculate theTcbased on these models and test if the combined model can predict the superconducting transition temperature (Tc) of the nanostructured FeSe monolayer well. To substantiate the recently announcedxypotential in the literature, we create a two-channel model to separately superimpose the dynamics of the electron in the upper and lower tetrahedral plane. The results of our two-channel model support the literature data. While scientists are still searching for a universal DFT functional that can describe the pairing mechanism of all iron-based superconductors, we base our model on the ARPES data to propose an empirical combination of a DFT functional for revising the electron–phonon scattering matrix in the superconducting state, which ensures that all electrons involved in iron-based superconductivity are included in the computation. Our computational model takes into account this amplifying effect of antiferromagnetism and the correction of the electron–phonon scattering matrix, together with the abnormal soft out-of-plane lattice vibration of the layered structure. This allows us to calculate theoreticalTcvalues of LiFeAs, NaFeAs and FeSe as a function of pressure that correspond reasonably well to the experimental values. More importantly, by taking into account the interfacial effect between an FeSe monolayer and its SrTiO3substrate as an additional gain factor, our calculatedTcvalue is up to 91 K and provides evidence that the strongTcenhancement recently observed in such monolayers withTcreaching 100 K may be contributed from the electrons within the ARPES range.