Airline efficiency growth is considered one of the key factors for aviation sustainability in Africa and for creating a successful relationship between aviation activities and economic development in the continent. This paper proposes estimating the efficiency of African airlines in the period 2010–2019 using a state-of-the-art stochastic frontier model disentangling persistent efficiency, transient efficiency, and unobserved heterogeneity. We also examine the impact on both persistent and transient efficiency of (i) ownership structure, (ii) political stability, (iii) airline geographical location, (iv) airline domicile country’s economic freedom, and (v) airline participation in a global alliance. We find evidence of relatively low efficiency and decreasing returns to scale, implying that it is important to achieve better utilization of inputs. Our findings also suggest that protectionism seems still an important driver of efficiency in a context characterized by a lack of liberalization. However, enhanced economic freedom is found to be more relevant in improving the efficiencies of African airlines, suggesting that policy interventions aimed at speeding up the liberalization process may help to remove the conditions that make air carriers operate inefficiently.