The purpose of this study was to identify behavioral and sociodemographic factors associated with intentions to engage with anti-vaping Instagram posts among a young adult population. This study proposes the following research questions: (1) Does e-cigarette use status influence intentions to engage with anti-vaping Instagram posts?, and (2) How are e-cigarette use and social media use associated? We recruited a convenience sample of young adults (N = 459; aged 18–30 years) in July of 2022 into an online experimental study from Prolific. Participants saw five image-based Instagram posts about the health harms of using e-cigarettes. Participants were then asked about their intentions to engage (“Comment on”, “Reshare”, “DM/Send this to a friend”, “Like”, and/or “Take a screenshot of”) with the posts. We used logistic regression to run adjusted models for each engagement outcome, which included fixed effects for sociodemographics, tobacco use, and social media/internet use. For the sum of the engagement outcome, we used Poisson regression. Total number of social media sites used was associated with intentions to “Like” the posts (p= 0.025) and the overall engagement score (p= 0.019), respectively. Daily internet use was associated with intentions to “Comment on” (p= 0.016) and “Like” (p= 0.019) the posts. Young adults who reported past 30-day e-cigarette use had higher odds of using Twitter (p= 0.013) and TikTok (p< 0.001), and a higher total number of social media sites used (p= 0.046), compared to young adults who reported never use e-cigarettes. The initial evidence from our exploratory research using a convenience sample suggests that social media campaigns about the harms of e-cigarette use may be an effective way to engage younger audiences, a generation that frequents social media. Efforts to disseminate social media campaigns should consider launching on multiple platforms, such as Twitter and TikTok, and consider e-cigarette use status when posting.