Backgroundhypertension is one of the major preventable risk factors for numerous diseases. The role of vitamin E in blood pressure (BP) has been controversial. We aimed to investigate the relationship between gamma-tocopherol serum concentration (GTSC) and BPMethodsData from 15,687 US adults from the National Health and Nutrition Examination Survey (NHANES) were analyzed. The correlations of GTSC with systolic BP (SBP), diastolic BP (DBP), and prevalence of hypertension were investigated by multivariate logistic regression models, generalized summation models, and fitted smoothing curves. Subgroup analyses were performed to investigate possible effect modifiers between them.ResultsWith each natural log increase in GTSC, SBP, and DBP increased by 1.28 mmHg (β1.28, 95% CI 0.71–1.84) and 1.15 mmHg (β1.15, 95% CI 0.72–1.57), respectively, bothPfor trend < 0.001; the prevalence of hypertension increased by 12% (OR 1.12, 95% CI 1.03–1.22),Pfor trend 0.008. In subgroup analysis, in drinkers, with each natural log increase in GTSC, SBP, and DBP increased by 1.77 mmHg (β1.77,95% CI 1.13–2.41) and 1.37 mmHg (β1.37,95% CI 0.9–1.85), respectively, whereas they were not correlated in non-drinkers.ConclusionGTSC was linearly and positively associated with SBP, DBP, and the prevalence of hypertension, and alcohol consumption may modify the relationship of GTSC with SBP and DBP.