Key PointsQuestionWould accelerated COVID-19 bivalent booster vaccination uptake in the US be associated with decreased outcomes of pediatric hospitalizations and student absenteeism?FindingsIn this decision analytical model using US population estimates, a simulation model revealed that booster campaigns achieving an uptake similar to seasonal influenza vaccination could have prevented an estimated 10 019 pediatric hospitalizations and 5 448 694 days of school absenteeism from October 1, 2022, to March 31, 2023.MeaningThese findings suggest that although COVID-19 prevention strategies often focus on older populations, the benefits of booster campaigns for children may be substantial.