Schizophrenia is a psychiatric syndrome that affects approximately 1 % of the world population and is among the top 10 reasons for disability. In this case-control study, we investigated the association between 15 insertion/deletion (Indel) polymorphisms and schizophrenia risk using pooled samples. In the present case-control study, 361 individuals with schizophrenia and 360 healthy individuals were included in the study. We examined the insertion/deletion polymorphisms inAPOB,ADRA2B,PDCD6IP,LRPAP1,TLR2,DHFR,VEGF,HLA-G,TPA,DBH,UCP2,FADS2,MDM2,TP53andSLC6A4genes. Our results revealed that the Del allele of theHLA-G14bp Indel polymorphism increased the risk of schizophrenia (OR=1.23, 95 % CI=1.01-1.52, p=0.045) and the Alu-allele of theTPAAlu+/Alu-polymorphism negatively associated with the schizophrenia risk (OR=0.67, 95 % CI=0.54-0.82, p<0.001).