Biological structures possess excellent damage tolerance, which makes them attractive for ballistic protection applications. This paper develops a finite element modelling framework to investigate the performance of several biological structures that are most relevant for ballistic protection, including nacre, conch, fish scales, and crustacean exoskeleton. Finite element simulations were conducted to determine the geometric parameters of the bio-inspired structures that can survive projectile impact. The performances of the bio-inspired panels were benchmarked against a monolithic panel with the same 4.5 mm overall thickness and projectile impact condition. It was found that the biomimetic panels that were considered possessed better multi-hit resistant capabilities compared to the selected monolithic panel. Certain configurations arrested a fragment simulating projectile with an initial impact velocity of 500 m/s, which was similar to the performance of the monolithic panel.