The paper works on the new combination between the No Motion No Integration filter (NMNI) and the Kalman Filter (KF) to optimize the conducted vibration for orientation angles during drone operation. The drone’s roll, pitch, and yaw with just accelerometer and gyroscope were analyzed under the noise impact. A 6 Degree of Freedom (DoF) Parrot Mambo drone with Matlab/Simulink package was used to validate the advancements before and after fusing NMNI with KF. The drone propeller motors were controlled at a suitable speed level to keep the drone on the zero-inclination ground for angle error validation. The experiments show that KF alone successfully minimizes the variation for the inclination, but it still needs the NMNI support to enhance the performance in noise deduction, with the error only about 0.02°. In addition, the NMNI algorithm successfully prevents the yaw/heading from gyroscope drifting due to the zero-value integration during no rotation with the maximum error of 0.03°.