A new Ni coordination polymer [Ni(MIP)(BMIOPE)]n(1) was constructed (BMIOPE = 4,4′-bis(2-methylimidazol-1-yl)diphenyl ether, and H2MIP = 5-methylisophthalic acid), possessing two-dimensional (2D) twofold parallel interwoven net structure with a 44∙62point symbol. Complex1has been successfully obtained based on mixed-ligand strategy. The fluorescence titration experiments revealed that complex1could act as multifunctional luminescent sensor to simultaneously detect UO22+, Cr2O72−and CrO42−, and NFT (nitrofurantoin). The limit of detection (LOD) values for complex1are 2.86 × 10−5, 4.09 × 10−5, 3.79 × 10−5and 9.32 × 10−5M for UO22+, Cr2O72−, CrO42−and NFT. The Ksvvalues are 6.18 × 103, 1.44 × 104, 1.27 × 104and 1.51 × 104M−1for NFT, CrO42−, Cr2O72−and UO22+. Finally, the mechanism of its luminescence sensing is studied in detail. These results manifest that complex1is a multifunctional sensor for sensitive fluorescent UO22+, Cr2O72−, CrO42−and NFT detection.