Humic, protein, and polysaccharide substances have been recognized as significant types of foulants in membrane systems. Despite the remarkable amount of research that has been performed on the interaction of these foulants, particularly humic and polysaccharide substances, with inorganic colloids in RO systems, little attention has been paid to the fouling and cleaning behavior of proteins with inorganic colloids in UF membranes. This research examined the fouling and cleaning behavior of bovine serum albumin (BSA) and sodium alginate (SA) with silicon dioxide (SiO2) and α-aluminum oxide (Al2O3) in individual and combined solutions during dead-end UF filtration. The results showed that the presence of SiO2or Al2O3in water alone did not cause significant fouling or a flux decline in the UF system. However, the combination of BSA and SA with inorganics was observed to have a synergistic effect on membrane fouling, in which the combined foulants caused higher irreversibility than individual foulants. Analysis of blocking laws demonstrated that the fouling mechanism shifted from cake filtration to complete pore blocking when the combined organics and inorganics were present in water, which resulted in higher BSA and SA fouling irreversibility. The results suggest that membrane backwash needs to be carefully designed and adjusted for better control of BSA and SA fouling with SiO2and Al2O3.