ABSTRACTHere, we report the draft genome sequences ofHoefleasp. strain E7-10 andHoeflea prorocentriPM5-8, isolated from a bleached hard coral and a culture of marine dinoflagellate, respectively. Genome sequencing for host-associated isolatesHoefleasp. E7-10 andH. prorocentriPM5-8 can provide basic genetic information to explore potential roles in their hosts.