ObjectiveIt has been reasoned that stressful life events tend to alter immune function thereby increasing the susceptibility to autoimmune diseases including multiple sclerosis (MS). Using the database of Kuwait National MS Registry, this quasi-experimental study assessed the impact of the first Gulf War (Iraqi invasion of Kuwait in 1990) on MS risk in Kuwait.MethodsMS incidence data from 1980 to 2019 were obtained from the Kuwait National MS Registry. Annual age-standardized incidence rates (ASIRs) (per 105person-years) were computed using the World Standard Population as a reference. Interrupted time series analysis with the option of autoregressive order (1) was used to evaluate the impact of the first Gulf War on MS risk by treating 1990 as an intervention year.ResultsEstimated baseline annual ASIR (per 105person-years) was 0.38 (95% CI: -1.02, 1.78;p= 0.587). MS ASIRs (per 105person-years) tended to increase significantly every year prior to 1990 by 0.45 (ASIR per 105person-years = 0.45; 95% CI: 0.15, 0.76;p= 0.005). During the first year of the first Gulf War, there seemed to be a non-significant increase (step change) in ASIRs (per 105person-years) of MS (ASIR per 105person-years = 0.85; 95% CI: − 5.16, 6.86;p= 0.775) followed by a non-significant increase in the annual trend in MS ASIRs per 105person-years (relative to the preintervention trend i.e., the difference between the pre-first Gulf War versus the post-first Gulf War trends) by 0.65 (ASIR per 105person-years = 0.65; 95% CI: − 0.22, 1.52;p= 0.138). However, a postestimation measure of the post-first Gulf War trend was statistically significant (ASIR per 105person-years = 1.10; 95% CI: 0.40, 1.80;p= 0.003), which implies that the post-first Gulf War trend in the annual ASIRs (per 105person-years) inclined to be the same as was the pre-first Gulf War (i.e., counterfactual of the pre-first Gulf War trend in annual ASIRs (per 105person-years) as if no first Gulf War took place).The Durbin-Watson test statistic (d= 1.89) showed almost non-significant autocorrelations across the time series observations on ASIRs (per 105person-years).ConclusionsThis study suggests that the first Gulf War was not significantly associated with the increasing trend in MS risk at population level in Kuwait neither with any short-term change nor with secular trend. Future studies may consider confirming the role of conflict-related stress or other stressful life events in potential exacerbation of MS risk along with unraveling biologically plausible mechanistic pathways.