AbstractDobutamine stress echocardiography (DSE) is a diagnostic tool for determining coronary artery disease. Considering hypotension and hypertension as important complications of DSE, we aimed to evaluate the blood pressure (BP) responses during DSE. Patients without known cardiovascular diseases who underwent DSE were included. We excluded patients who had hypertension, diabetes mellitus, a known history of cardiovascular diseases, and those taking vasoactive medications. Systolic (SBP) and diastolic (DBP) blood pressure were recorded at baseline and peak stress. We included 688 patients with an age of 57.9 ± 12.01 years. During DSE, SBP (+19.72 ± 26.51 mm Hg,p <0.001), DBP (+5.52 ± 17.35 mm Hg,p <0.001), and HR (+54.05 ± 22.45 bpm,p <0.001) significantly increased from baseline to peak stress. The normal cut‐off value was measured between 101–210 mm Hg for SBP and 50–121 mm Hg for DBP. According to this normal cutoff, 11 (1.3%) and 30 (4.4%) patients had hypotensive and hypertensive SBP and 15 (2.2%) and 21 (3.1%) patients had hypotensive and hypertensive DBP, respectively. The hypotensive response was correlated with baseline SBP (r= 0.6,p= 0.001) and atropine (r= −2.18,p= 0.043), and the hypertensive response was correlated with baseline SBP (r= 0.048,p <0.001). Baseline BP and atropine consumption were the independent variables associated with the outside‐the‐normal range of blood pressure responses.