In the current study, two molds,Aspergillus flavus(ACC# LC325160) andPenicillium chrysogenum(ACC# LC325162) were inoculated into two types of wood to be examined using scanning electron microscopy-energy dispersive X-ray (SEM–EDX) and computerized tomography (CT) scanning.Ficus sycomorus, a non-durable wood, andTectona grandis, a durable wood, were the two wood blocks chosen, and they were inoculated with the two molds and incubated for 36 months at an ambient temperature of 27 ± 2 °C and 70 ± 5% relative humidity (RH). The surface and a 5-mm depth of inoculated wood blocks were histologically evaluated using SEM and CT images. The results showed thatA. flavusandP. chrysogenumgrew enormously on and inside ofF. sycomoruswood blocks, butT. grandiswood displayed resistance to mold growth. The atomic percentages of C declined from 61.69% (control) to 59.33% inF. sycomoruswood samples inoculated withA. flavuswhile O increased from 37.81 to 39.59%.P. chrysogenumcaused the C and O atomic percentages inF. sycomoruswood to drop to 58.43%, and 26.34%, respectively. C with atomic percentages in Teak wood’s C content fell from 70.85 to 54.16%, and 40.89%, after being inoculated withA. flavusandP. chrysogenum. The O atomic percentage rose from 28.78 to 45.19% and 52.43%, when inoculated withA. flavusandP. chrysogenum, respectively. Depending on how durable each wood was, The examined fungi were able to attack the two distinct types of wood in various deterioration patterns.T. grandiswood overtaken by the two molds under study appears to be a useful material for a variety of uses.