Simple SummaryIt is known that socioeconomically disadvantaged people more often develop esophageal cancer. Therefore, we assumed that those patients more often have advanced tumor stages and comorbidities at the time of surgery and, thus, are more likely to suffer from postoperative complications and poorer survival. To clarify this, we used the purchasing power of the respective postal codes to estimate the socioeconomic status (SES) of 310 patients who had undergone surgery for esophageal cancer in our institution. Fortunately, it turns out that SES was not associated with tumor stage or comorbidities at the time of surgery. Moreover, SES was neither related to postoperative complications nor overall survival. In conclusion, socioeconomic inequalities of patients treated at a high-volume center do not affect treatment results.AbstractIn Germany, socioeconomically deprived citizens more often develop esophageal carcinoma, since typical risk factors follow the social gradient. Therefore, we hypothesized that socioeconomic deprivation might also be associated with advanced tumor stages and comorbidities at the time of surgery. As a consequence, socioeconomic deprivation may be related to postoperative complications and reduced overall survival. Therefore, 310 patients who had undergone esophagectomy for cancer in curative intent between 2012 and 2020 at the University Medical Center Hamburg-Eppendorf (UKE) were included in this study. Socioeconomic status (SES) was estimated using the purchasing power of patients’ postal codes as a surrogate parameter. No association was found between SES and tumor stage or comorbidities at the time of surgery. Moreover, SES was neither associated with postoperative complications nor overall survival. In conclusion, socioeconomic inequalities of patients treated at a high-volume center do not affect treatment outcomes.