Introduction.Carbapenems are usually used in the treatment of infections caused by cephalosporin-resistantEnterobacterales; however, the increase in carbapenem-resistantEnterobacterales(CRE) has become one of the most important problems in public health.Hafnia alveiis associated with intestinal and extraintestinal infections, especially in patients with any chronic disease or some type of immunosupression.H. alveiis resistant to first-generation aminopenicillins and cephalosporins owing to the β-lactamase (Amp C) in their chromosome; the only carbapenem-resistantHafniastrain described until now was due to a lack of the OmpK36 protein that plays an important role in permeability to carbapenems.Case presentation.We present the case of a 65-year-old male diagnosed with acute lithiasic cholecystitis. Culture of the biliary prosthesis yielded a OXA-48-producingH. alveithat was identified by MALDI-TOF (matrix-assisted laser desorption/ionization-time of flight) MS. Carbapenemase production was detected by immunochromatography and confirmed by sequencing.Conclusion.To our knowledge, this is the first report of OXA-48-producingH. alveiprobably obtained by horizontal transfer fromEnterobacter cloacaeOXA-48 isolated in previous samples.