An experimental investigation on partially PBO (short of Polyparaphenylenebenzobisthiazole) FRCM (Fiber Reinforced Cementitious Mortar) confined clay brick masonry columns has been conducted. Ten small-scale specimens measuring 445 mm high with a square cross-section of the 250 mm side have been tested under monotonic axial loading until collapse. Two columns were unconfined, while the remaining ones were confined with single-layer PBO FRCM jackets varying the geometric configuration along their height. The vertical spacing ratiosf’/sf, beingsf’andsfthe center-to-center and the net spacings between two consecutive jackets, respectively, was considered as the key parameter of the confinement configuration. The failure modes, stress–strain curves and peak axial stress and strain values are reported. The experimental results have been compared to the predictions of models found in the Italian guidelines CNR DT 215/2018 and the American ACI 549-R20 standards. The main aspects analyzed involved (i) the evaluation of the effectiveness of partial confinement on the mechanical response of columns, (ii) the definition of the mechanical and geometrical parameters that influence the structural response of partially confined columns, and (iii) the development of appropriate analytical models for the prediction of the resisting capacity of masonry columns partially confined with PBO FRCM.