Scarce fossil tetrapod burrows have been recorded in Cretaceous rocks, which is probably linked to the dominant equable climates that existed for most of this period. The occurrence of Cretaceous tetrapod burrows from Patagonia (Chubut Province, Argentina) dated between 118 and 115 million years ago, gives insights into their paleoecology and paleoenvironment. The rocks containing the tetrapod burrows are of pyroclastic origin and represent eolian dunes and ash-fall deposits, some reworked by fluvial currents and others showing soil development. Fossil burrow casts preserved in a paleosol are composed by a ramp with a slightly curved or straight path in plan-view and lacking bifurcation, a rounded termination with no enlargement, showing a reniform cross-section, and are assigned to the ichnospeciesReniformichnus katikatii.The strongly flattened cross-sectional shape of the burrow casts and comparison with modern lizard burrows suggest that the producers were lepidosaurs (body mass = 50–323 g). Among Cretaceous fossorial lepidosaurs from Patagonia, the best candidate is an eilenodontine sphenodontian. Sphenodontians burrowed in the fossil soils where also arthropods, earthworms and shrubby plants thrived. The rare occurrence of tetrapod burrows in Cretaceous rocks is linked to stressing conditions related to frequent arrival of volcanic ash and a semiarid seasonal climate.