AbstractIntroductionEmerging long‐acting (LA) prevention and treatment medicines, technologies and regimens could be game‐changing for the HIV response, helping reach the ambitious goal of halting the epidemic by 2030. To attain this goal, the rapid expansion of at‐scale, sustainable, quality‐assured, and affordable supplies of LA HIV prevention and treatment products through accelerated and stronger competition, involving both originator and generic companies, will be essential. To do this, global health stakeholders should take advantage of voluntary licensing of intellectual property (IP) rights, such as through the United Nations‐backed, not‐for‐profit Medicines Patent Pool, as a proven mechanism to support broad access to existing HIV medicines across low‐ and middle‐income countries (LMICs).DiscussionWhile voluntary licensing may unlock the possibility for generic competition to take place ahead of patent expiry, there are additional elements—of amplified importance for more complex LA HIV medicines—that need to be taken into consideration. This paper discusses 10 enablers of voluntary licensing of IP rights as a model to rapidly expand at‐scale, sustainable, quality‐assured, and affordable supplies of LA HIV prevention and treatment regimens in LMICs:Identifying promising LA technology platforms and drug formulations at an early developmental stage and engaging with patent holdersConsolidating a multidisciplinary network and strengthening early‐stage coordination and collaboration to foster innovationEmbedding public health considerations in product design and deliveryBuilding innovative partnerships for product development and commercializationRaising awareness of and creating demand for emerging LA productsEstimating the market size, ensuring sufficient competition and protecting sustainabilityUsing technology transfer and hands‐on technical support to reduce product development timelines and costsExploring de‐risking mechanisms and financial incentives to support generic manufacturersOptimizing strategies for generic product development and regulatory filingsAligning and coordinating efforts of stakeholders across the value chain.ConclusionsRapid access to emerging LA prevention and treatment regimens and technologies can be facilitated by voluntary licensing—catalyzed and supplemented by enabling collaborative and non‐duplicative efforts of various other stakeholders. This can effectively lead to improved—accelerated and cheaper—access to quality‐assured medicines for populations in LMICs.