Introduction: The dentistry industry has seen a number of exciting new advancements in recent years, many of which have been made possible by the introduction of automated technologies such as computer-aided design and computer-aided manufacturing (CAD/CAM). Despite the fact that these new approaches simplify the fabrication process in favor of decreased material consumption and improved time efficiency, it is possible that they may have an effect on the prosthesis’s fitness, which in turn may affect how long they will last.Purpose: The purpose of this in vitro study was to evaluate the trueness and fitness of cobalt-chromium (Co-Cr) crown copings fabricated by selective laser melting (SLM), milling, and conventional casting methods.Materials and Methods: A zirconium die was fabricated and scanned with a laboratory scanner to manufacture the Co-Cr metal copings for three groups (n = 12). In group A, the copings were fabricated by a 3D printing technique called SLM; in group B, the copings were fabricated by the milling technique; and in group C, the copings were fabricated by the conventional lost-wax method. After fabrication, the trueness and the internal fitness of the copings were evaluated using a metrology software program (Geomagic Control X, 3D Systems Inc., Rock Hill, SC). The one-way ANOVA and Tukey’s honestly significant difference test were used to statistically analyze the data.Results: The highest root mean square (RMS) value of trueness was for CAD/CAM milling, and the highest mean of horizontal gaps was for the casted (lost-wax technique) group. There were highly significant differences in the mean RMS value of trueness and the mean horizontal gaps between the three groups.Conclusion: The fabrication method of Co-Cr crown copings has an effect on the trueness and fitness of the copings.