Textile materials with fluorescent, repellent, or antimicrobial properties are increasingly used in common applications. Obtaining multi-functional coatings is of wide interest, especially for applications related to signaling or to the medical field. In order to increase the performance (color properties, fluorescence lifetime, self-cleaning or antimicrobial properties) of textile materials with special uses, a series of research was carried out regarding the modification of surfaces with nanosols. In this study, coatings with multiple properties were obtained by depositing nanosols on cotton fabrics generated through sol–gel reactions. These multifunctional coatings are hybrid materials in which the host matrix is generated using tetraethylorthosilicate (TEOS) and network modifying organosilanes:dimethoxydimethylsilane (DMDMS) or dimethoxydiphenylsilane (DMDPS) in a 1:1 mass ratio. Two curcumin derivatives were embedded in siloxane matrices, a yellow one (CY) that is identical to bis-demethoxycurcumin (one of the natural constituents in turmeric) and a red dye (CR) that has a N,N-dimethylamino group grafted in position 4 of the dicinnamoylmethane skeleton of curcumin. The nanocomposites obtained by embedding curcumin derivatives in siloxane matrices were deposited on cotton fabric and studied in relation to the dye and the type of host matrix. Fabrics coated with such systems provide a hydrophobic surface, have fluorescent and antimicrobial properties, change color depending on the pH, and therefore can be used in various fields where textiles provide signaling properties, self-cleaning, or antibacterial protection. The coated fabrics maintained their good multifunctional properties even after several washing cycles.