Novel paradigms of strong ergodicity breaking have recently attracted significant attention in condensed matter physics. Understanding the exact conditions required for their emergence or breakdown not only sheds more light on thermalization and its absence in closed quantum many-body systems, but it also has potential benefits for applications in quantum information technology. A case of particular interest is many-body localization whose conditions are not yet fully settled. Here, we prove that spin chains symmetric under a combination of mirror and spin-flip symmetries and with a non-degenerate spectrum show finite spin transport at zero total magnetization and infinite temperature. We demonstrate this numerically using two prominent examples: the Stark many-body localization system (Stark-MBL) and the symmetrized many-body localization system (symmetrized–MBL). We provide evidence of delocalization at all energy densities and show that delocalization persists when the symmetry is broken. We use our results to construct two localized systems which, when coupled, delocalize each other. Our work demonstrates the dramatic effect symmetries can have on disordered systems, proves that the existence of exact resonances is not a sufficient condition for delocalization, and opens the door to generalization to higher spatial dimensions and different conservation laws.