Background: Pelvic ring fractures are life-threatening injuries that have a severe impact on patients’ lives. The aim of this clinical study was to evaluate the outcome of surgical treatment in terms of Quality of Life (QoL), return to work, functional results and sport activities, and post-operative sexual dysfunction. Methods: A retrospective study with patients retrieved from a Level 1 Trauma Center was performed. Minimum patient follow-up was 12 months: QoL was evaluated with the SF-12 (Short Form Survey) questionnaire, return to work with the Workplace Activity Limitation Survey (WALS), functional outcomes and sport activities with the Harris Hip Score and Tegner activity score, respectively, and sexual function damage with a 0–10 NRS. Results: Seventy-six patients (41 males and 35 females) were enrolled, with a mean age at surgery of 56.4 years (18–89 years). Overall, their quality of life remained significantly affected, with male patients reporting worse WALS outcomes (p= 0.036), sexual damage (p= 0.001), and SF-12 Bodily Pain (p= 0.046) than females. In particular, 70.7% of men and 45.7% of women reported sexual limitations, and only 53.7% returned to their job, with 35.2% losing their job as a consequence of the pelvic ring disruption. Conclusions: An important deterioration in general health state, return to work, and sexual function was documented in patients treated surgically for pelvic trauma, especially in male patients. There are disabling secondary sequels at all levels beyond the mere functional scores, and both patients and clinicians should be aware and have the correct expectations.