AbstractPURPOSE:To implement the technical feasibility of an AI-based software prototype optimized for the detection of COVID-19 pneumonia in CT datasets of the lung and the differentiation between other etiologies of pneumonia.METHODS:This single-center retrospective case–control-study consecutively yielded 144 patients (58 female, mean age 57.72 ± 18.25 y) with CT datasets of the lung. Subgroups including confirmed bacterial (n= 24, 16.6%), viral (n= 52, 36.1%), or fungal (n= 25, 16.6%) pneumonia and (n= 43, 30.7%) patients without detected pneumonia (comparison group) were evaluated using the AI-basedPneumonia Analysis prototype. Scoring (extent, etiology) was compared to reader assessment.RESULTS:The software achieved an optimal sensitivity of 80.8% with a specificity of 50% for the detection of COVID-19; however, the human radiologist achieved optimal sensitivity of 80.8% and a specificity of 97.2%. The mean postprocessing time was 7.61 ± 4.22 min. The use of a contrast agent did not influence the results of the software (p= 0.81). The mean evaluated COVID-19 probability is 0.80 ± 0.36 significantly higher in COVID-19 patients than in patients with fungal pneumonia (p< 0.05) and bacterial pneumonia (p< 0.001). The mean percentage of opacity (PO) and percentage of high opacity (PHO ≥ −200 HU) were significantly higher in COVID-19 patients than in healthy patients. However, the total mean HU in COVID-19 patients was −679.57 ± 112.72, which is significantly higher than in the healthy control group (p< 0.001).CONCLUSION:The detection and quantification of pneumonia beyond the primarily trained COVID-19 datasets is possible and shows comparable results for COVID-19 pneumonia to an experienced reader. The advantages are the fast, automated segmentation and quantification of the pneumonia foci.