Objective.To review the epidemiology of coagulase-negative staphylococci (CoNS) in England over the recent 12 year period.Methods.Laboratory-confirmed CoNS reported from sterile sites in patients in England to the UK Health Security Agency (UKHSA) between 2010 and 2021 were extracted from the national laboratory database and analysed.Results.Overall, 668 857 episodes of CoNS were reported. Unspeciated CoNS accounted for 56 % (374 228) of episodes, followed byStaphylococcus epidermidis(26 %; 174 050),S. hominis(6.5 %; 43 501) andS. capitis(3.9 %; 25 773). Unspeciated CoNS increased by 8.2 % (95 % CI, 7.1–9.3) annually between 2010 and 2016, then decreased annually by 6.4 % (95 % CI: −4.8 to −7.9) until 2021. Speciated CoNS increased by 47.6 % (95 % CI, 44.5–50.9) annually between 2010 and 2016 and increased annually by 8.9 % (95 % CI: 5.1 to 12.8) until 2021. Antimicrobial susceptibility profiles differed by species.Conclusions.Reports of CoNS from normally sterile body sites in patients in England increased between 2010 and 2016 and remained stable between 2017 and 2021. There has been a striking improvement in species-level identification of CoNS in recent years. Monitoring trends in CoNS epidemiology is crucial for development of observational and clinical intervention studies on individual species.