This report illustrates a case of acute supraglottitis, a rare condition that can be easily diagnosed, but can quickly be deadly if missed. The patient presented with a sore throat and unilateral neck swelling that progressed to voice changes and difficulty handling secretions. Initially, radiographs were obtained followed by computed tomography. Imaging raised concern for supraglottitis; therefore otolaryngology consult was obtained and flexible laryngoscopy confirmed the diagnosis. The patient received a prophylactic awake fiberoptic intubation at the bedside and was started on intravenous antibiotics and steroids. She quickly improved and is expected to make a full recovery. Trainees and current practicing physicians in today’s post-Haemophilus influenzatype b vaccination period rarely encounter epiglottitis or supraglottitis. This case reminds us to keep this uncommon but quickly progressive and dangerous condition in mind to avoid a missed diagnosis which can lead to significant morbidity and mortality.TopicsSupraglottitis, acute supraglottitis, adult, intubation, antibiotic, microbiology.