Candida auris(C. auris) is an emerging multidrug-resistant fungal pathogen that represents a significant public health challenge as it can spread rapidly and result in high mortality rates. The mannans on theC. auriscell surface are potent immunogens and attractive targets for developing a glycoconjugate vaccine. We synthesized the oligosaccharides resembling cell surface mannans ofC. aurisand printed them onto microarray slides that were used to screen plasma from mice infected withC. auris. IgM antibodies in mouse plasma recognize the β-1,2 linkage present inC. aurissurface mannans. Disaccharide 19 emerged from glycan array screening as a lead for developing a vaccine againstC. auris, as the majority of patient plasma samples showed antibodies against this glycan. The synthetic oligosaccharides can be used for the early detection ofC. aurisinfections.