Multiple solitary plasmacytoma is the rare presentation of plasma cell neoplasm that can mimic multiple metastases. Primary endobronchial plasmacytoma is an extremely rare condition of extramedullary plasmacytoma. Here, we describe a case of multiple solitary plasmacytoma that initially presented with an endobronchial mass.Teaching Point:The differential diagnosis of multiple lesions in the airway is mainly metastasis and multiple solitary plasmacytoma.