This longitudinal study assessed the impact of the COVID-19 pandemic on children with autism spectrum disorder (ASD;n= 62;Mage= 13 years) by measuring emotional and behavioral problems before and during the pandemic, and by comparing this change to a matched sample of children without ASD (n= 213;Mage= 16 years). Moreover, we examined whether indicators of parental well-being promoted resilience of children with ASD. Results showed that the mean change in problems did not differ between children with and without ASD. Importantly, some children showed an increase in problems, while others showed resilience. Parental well-being indicators were not related to resilience among children with ASD. The interindividual variability in responses, particularly among children with ASD, highlights the need for personalized support.Supplementary InformationThe online version contains supplementary material available at 10.1007/s10803-022-05846-y.