PurposeTo investigate the impact of treatment time and patterns in inoperable stage III non-small cell lung cancer (NSCLC) following concurrent chemoradiotherapy (cCRT) ± immune checkpoint inhibitors (ICIs).MethodsPatients were stratified by treatment year: A (2011–2014), B (2015–2017) and C (2018–2020). Tumor- and treatment-related characteristics regarding locoregional recurrence-free survival (LRRFS), progression-free survival (PFS) and overall survival (OS) were investigated.ResultsOne hundred and thirty-six consecutive patients were analyzed. All patients completed thoracic radiotherapy (TRT) to a total dose ≥ 60.0 Gy; 36 (26%) patients received ICI. Median PFS in subgroups A, B and C was 8.0, 8.2 and 26.3 months (p= 0.007). Median OS was 19.9 months, 23.4 months and not reached (NR), respectively. In group C, median LRRFS and PFS were 27.2 vs. NR; and 14.2 vs. 26.3 months in patients treated with and without ICI. On multivariate analysis planning target volume (PTV) ≥ 700 cc was a negative prognosticator of LRRFS (HR 2.194;p= 0.001), PFS (HR 1.522;p= 0.042) and OS (HR 2.883;p= 0.001); ICI was a predictor of LRRFS (HR 0.497;p= 0.062), PFS (HR 0.571;p= 0.071) and OS (HR 0.447;p= 0.1). In the non-ICI cohort, multivariate analyses revealed PTV ≥ 700 cc (p= 0.047) and a maximum standardized uptake value (SUVmax) ≥ 13.75 (p= 0.012) were predictors of PFS; PTV ≥ 700 cc (p= 0.017), SUVmax≥ 13.75 (p= 0.002) and a total lung V20 ≥ 30% (V20 ≥ 30) (p< 0.05) were predictors of OS.ConclusionsPatients treated after 2018 had improved survival regardless of ICI use. Implementation of ICI resulted in further significant increase of all tested survival endpoints. PTV ≥ 700 cc and ICI were only prognosticators for LRRFS, PFS and OS in the analyzed cohort.