Hydrological disasters, such as floods, can have dire consequences for human societies. Historical information plays a key role in detecting whether particular types of hydrological disasters have increased in frequency and/or magnitude and, if so, they are more likely attributable to natural or human-induced climatic and other environmental changes. The identification of regions with similar flood conditions is essential for the analysis of regional flooding regimes. To this end, we here present the longest existing flood reconstruction for the Eastern Liguria Area (ELA) in northwestern Italy, covering 1582 to 2022 CE, which offers a case study representative of the central Mediterranean region. An Annual Flood Intensification Index was developed to transform the historical data into a continuous annual hydrological time-series contained by a homogeneous data structure for the study-area. We found two change-points (trend breaks) in the reconstructed time-series, in 1787 and 1967, with only occasional heavy floods comparable to present-day disasters occurring before the first change-point, and an increasing intensification of floods after the second change-point up to the present day. The recent intensification of flooding in the ELA, associated with changes in land use and land cover, also appears to coincide with phases in which hydrological hazards have become more changeable and extreme in disaster-affected areas. This is evidenced by river basin responses to human-induced disturbances.