This paper emerged as a result of Anishinabe and non-Indigenous scholars discussing the basic principles behind systems thinking. By asking the question “what is a system?”, we uncovered that our very understanding of what makes a system was vastly different. As scholars working in cross-cultural and inter-cultural environments, these differing worldviews can create systemic challenges in unpacking complex problems. Trans-systemics offers language to unearth these assumptions by the recognition that the dominant, or “loudest”, systems are not always the most appropriate or equitable. It goes beyond critical systems thinking to identify that tackling complex problems requires the recognition that there are multiple, overlapping systems and worldviews at play. We identified three key takeaways from Indigenous trans-systemics for socio-ecological systems thinkers: (1) trans-systemics is a call to humility, asking us to critically examine our patterns of thought and behavior; (2) by exploring humility, trans-systemics allows us to move past the autopoiesis of Eurocentric systems thinking to consider interdependence; and (3) to utilize Indigenous trans-systemics, we need to fundamentally reconsider how we understand the systems around us and bring in outside tools and concepts to enact meaningful systems change.