ObjectiveTo study maternal anxiety in pregnant women without comorbidities in the context of the COVID-19 outbreak in Brazil and to study maternal knowledge and concerns about the pandemic.MethodsThis is a secondary analysis from a national multicenter cross-sectional study performed in 10 cities, from June to August, 2020, in Brazil. Interviewed postpartum women, without medical or obstetrical comorbidities, were included in the present subanalysis. A structured questionnaire and the Beck Anxiety Inventory (BAI) were applied.ResultsOut of the 1,662 women, 763 (45.9%) met the criteria for the current analysis and 16.1% presented with moderate and 11.5% with severe maternal anxiety. Moderate or severe maternal anxiety was associated with high school education (odds ratio [OR]:1.58; 95% confidence interval [CI]:1.04–2.40). The protective factor was cohabiting with a partner (OR: 0.46; 95%CI: 0.29–0.73). There was a positive correlation between the total BAI score and receiving information about care in the pandemic (rpartial0.15;p< 0.001); concern about vertical transmission of COVID-19 (rpartial0.10;p= 0.01); receiving information about breastfeeding (rpartial0.08;p= 0.03); concerns about prenatal care (rpartial0.10;p= 0.01), and concerns about the baby contracting COVID-19 (rpartial0.11;p= 0.004). The correlation was negative in the following aspects: self-confidence in protecting from COVID-19 (rpartial0.08;p= 0.04), having learned (rpartial0.09;p= 0.01) and self-confidence in breastfeeding (rpartial0.22;p< 0.001) in the context of the pandemic.ConclusionThe anxiety of pregnant women without medical or obstetrical comorbidities was associated to high school educational level and not living with a partner during the COVID-19 pandemic. Self-confidence in protecting against COVID-19 and knowledge about breastfeeding care during the pandemic reduced maternal anxiety.