IntroductionDeep-learn methods based on convolutional neural networks (CNNs) have demonstrated impressive performance in depression analysis. Nevertheless, some critical challenges need to be resolved in these methods: (1) It is still difficult for CNNs to learn long-range inductive biases in the low-level feature extraction of different facial regions because of the spatial locality. (2) It is difficult for a model with only a single attention head to concentrate on various parts of the face simultaneously, leading to less sensitivity to other important facial regions associated with depression. In the case of facial depression recognition, many of the clues come from a few areas of the face simultaneously, e.g., the mouth and eyes.MethodsTo address these issues, we present an end-to-end integrated framework called Hybrid Multi-head Cross Attention Network (HMHN), which includes two stages. The first stage consists of the Grid-Wise Attention block (GWA) and Deep Feature Fusion block (DFF) for the low-level visual depression feature learning. In the second stage, we obtain the global representation by encoding high-order interactions among local features with Multi-head Cross Attention block (MAB) and Attention Fusion block (AFB).ResultsWe experimented on AVEC2013 and AVEC2014 depression datasets. The results of AVEC 2013 (RMSE = 7.38, MAE = 6.05) and AVEC 2014 (RMSE = 7.60, MAE = 6.01) demonstrated the efficacy of our method and outperformed most of the state-of-the-art video-based depression recognition approaches.DiscussionWe proposed a deep learning hybrid model for depression recognition by capturing the higher-order interactions between the depression features of multiple facial regions, which can effectively reduce the error in depression recognition and gives great potential for clinical experiments.