Key PointsQuestionDoes parenteral nutrition duration improve the sensitivity and maintain high specificity of DIGIROP models in predicting retinopathy of prematurity (ROP) treatment?FindingsIn this prognostic study, among 11 139 ROP-screened Swedish infants with 14 or more vs less than 14 days of parenteral nutrition, 64.0% vs 18.5%, respectively, had any ROP and 18.1% vs 1.6% had ROP treatment. DIGIROP 2.0 models were updated to include all ROP-screened infants regardless of gestational age and presented a 100% sensitivity, high specificity, and superiority to WINROP and G-ROP models.MeaningThe validated DIGIROP 2.0 decision support tool is suggested to be an efficient individual prediction tool for safe release of infants from unnecessary ROP screening examinations.