In the context of intelligent and integrative lighting, in addition to the need for color quality and brightness, the non-visual effect is essential. This refers to the retinal ganglion cells (ipRGCs) and their function, which were first proposed in 1927. The melanopsin action spectrum has been published inCIE S 026/E: 2018with the corresponding melanopic equivalent daylight (D65) illuminance (mEDI), melanopic daylight (D65) efficacy ratio (mDER), and four other parameters. Due to the importance ofmEDIandmDER, this work synthesizes a simple computational model ofmDERas the main research objective, based on a database of 4214 practical spectral power distributions (SPDs) of daylight, conventional,LED, and mixed light sources. In addition to the high correlation coefficientR2of 0.96795 and the 97% confidence offset of 0.0067802, the feasibility of themDERmodel in intelligent and integrated lighting applications has been extensively tested and validated. The uncertainty between themEDIcalculated directly from the spectra and that obtained by processing theRGBsensor and applying themDERmodel reached ± 3.3% after matrix transformation and illuminance processing combined with the successfulmDERcalculation model. This result opens the potential for low-costRGBsensors for applications in intelligent and integrative lighting systems to optimize and compensate for the non-visual effective parametermEDIusing daylight and artificial light in indoor spaces. The goal of the research onRGBsensors and the corresponding processing method are also presented and their feasibility is methodically demonstrated. A comprehensive investigation with a huge amount of color sensor sensitivities is necessary in a future work of other research.