IntroductionPseudoexfoliation (PXF) has a varied impact on the eye and has a complex relationship with pterygium and cataracts. We explored this study to estimate the proportion of PXF and its association with pterygium in cataract patients from a semi-arid district in South India.MethodsThis retrospective observational study was conducted at Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, a tertiary care referral center in Kolar, India. Cataract patients attending the hospital between December 2020 and August 2022 were included based on non-probability sampling. Three hundred fifty-two patients were included based on the inclusion and exclusion criteria, and their records on demographic details and ocular examination were collected.ResultsOut of 352 patient records, 184 (52.27%) were males, with the mean age being 67.84 ± 13.08 years. In all, 95% of the patients were agricultural laborers exposed to sunlight and dust for more than six hours daily. It was observed that the proportion of PXF and pterygium in the study population was 28.40% (100) and 56.33% (199), respectively. The mean age of the PXF patients was 75.53 ± 6.26 years. The association of PXF with pterygium was statistically significant (p < 0.05).ConclusionPXF is one of the significant causes of complications in cataract surgery and blindness, which can be detected only in the end stages. This study draws a statistically significant association between pterygium and PXF. Identifying preclinical cases of PXF and halting its progression by avoiding risk factors such as prolonged exposure to sunlight, UV radiation, and dust should be focused on risk-prone geographical areas.