Key PointsQuestionIs exposure to early adverse childhood experiences (ACEs) associated with reduced midlife educational attainment, and if so, did participation in the Child-Parent Center (CPC) comprehensive Early Childhood Education (ECE) program attenuate these associations?FindingsIn this cohort study of 1083 participants, early ACEs were significantly associated with reduced midlife educational attainment for the comparison group, but not for the CPC early intervention group. The CPC preschool program appeared to compensate for associations between ACEs and educational attainment; CPC attendees with early ACEs had similar educational trajectories to those of CPC attendees without early ACEs.MeaningThis study suggests that comprehensive ECE can be a scalable approach for promoting long-term educational success after early experiences of ACEs.