ObjectivesThis study aimed to evaluate and compare the effect of plasma treatment versus conventional treatment on the micro shear bond strength (μSBS), surface roughness, and wettability of three different CAD/CAM materials.Materials and methodsSixty cylindrical specimens (5 mm diameter × 3 mm height) were prepared from three different CAD/CAM materials: Group A: Zirconia, Group B: Lithium disilicate, and Group C: Resin nano-ceramic. Each group was subdivided into two subgroups according to surface treatment used: Subgroup I: Conventional treatment, zirconia was sandblasted with Al2O3, while lithium disilicate and resin nano-ceramic were etched with hydrofluoric acid. Subgroup II: Plasma treatment, the surface of each material was treated with a plasma device (PiezoBrush® PZ3 Handheld Device, Relyon Plasma, Regensburg, Germany). G-Multi PRIMER was applied, then self-adhesive cement (G-CEM ONE) was applied using a split mold (1 mm diameter × 3 mm height), and μSBS was tested in a universal testing machine. The surface roughness was measured using a profilometer. Nine additional specimens of each material for wettability test using an optical tensiometer.Statistical analysisThe data were analyzed using ANOVA and Bonferroni test at a level of significance of 0.05.ResultsThe highest mean of μSBS was recorded by AII (27.3 MPa), while the lowest was recorded by AI (17.9 MPa). One-way ANOVA test revealed a significant difference among groups. Bonferroni test showed each two subgroups significant difference except subgroups AI, CI and BII, CII, where there was a non-significant difference. For all CAD/CAM materials, conventional treatment increased the surface roughness compared to plasma treatment, while the contact angle decreased after plasma treatment.ConclusionPlasma treatment increased the μSBS of resin cement to zirconia significantly while not significantly affecting the μSBS of resin nano-ceramic. Conventional treatment of lithium disilicate provided significantly higher μSBS than plasma treatment.