IntroductionRecent advancements in technology have propelled the applications of artificial intelligence (AI) in various sectors, including healthcare. Medical imaging has benefited from AI by reducing radiation risks through algorithms used in examinations, referral protocols, and scan justification. This research work assessed the level of knowledge and awareness of 225 second- to fourth-year medical imaging students from public universities in Ghana about AI and its prospects in medical imaging.MethodsThis was a cross-sectional quantitative study design that used a closed-ended questionnaire with dichotomous questions, designed on Google Forms, and distributed to students through their various class WhatsApp platforms. Responses were entered into an Excel spreadsheet and analyzed with the Statistical Package for the Social Sciences (SPSS) software version 25.0 and Microsoft Excel 2016 version.ResultsThe response rate was 80.44% (181/225), out of which 97 (53.6%) were male, 82 (45.3%) were female, and 2 (1.1%) preferred not to disclose their gender. Among these, 133 (73.5%) knew that AI had been incorporated into current imaging modalities, and 143 (79.0%) were aware of AI's emergence in medical imaging. However, only 97 (53.6%) were aware of the gradual emergence of AI in the radiography industry in Ghana. Furthermore, 160 people (88.4%) expressed an interest in learning more about AI and its applications in medical imaging. Less than one-third (32%) knew about the general basic application of AI in patient positioning and protocol selection. And nearly two-thirds (65%) either felt threatened or unsure about their job security due to the incorporation of AI technology in medical imaging equipment. Less than half (38% and 43%) of the participants acknowledged that current clinical internships helped them appreciate the role of AI in medical imaging or increase their level of knowledge in AI, respectively.Discussion. Generally, the findings indicate that medical imaging students have fair knowledge about AI and its prospects in medical imaging but lack in-depth knowledge. However, they lacked the requisite awareness of AI's emergence in radiography practice in Ghana. They also showed a lack of knowledge of some general basic applications of AI in modern imaging equipment. Additionally, they showed some level of misconception about the role AI plays in the job of the radiographer.ConclusionDecision-makers should implement educational policies that integrate AI education into the current medical imaging curriculum to prepare students for the future. Students should also be practically exposed to the various incorporations of AI technology in current medical imaging equipment.