Air pollution has been integrated into global challenges over the last few years due to its negative impact on the health of human beings, increasing socio-economic risks, and its contribution to climate change. This study attempts to evaluate the current status of Iran’s air pollution with regard to the sources of emissions, control policies, and the health and climate consequences that have resulted through available data from monitoring stations reported in the literature, official documents, and previously published papers. Many large cities in Iran surpass the permissible concentration of air pollutants, particularly particulate matter, sulfur dioxide, black carbon, and ozone. Although regulations and policies are in place and enormous efforts are being made to address air pollution issues in the country, implementation and enforcement are not as effective as they could be. The significant challenges may be regarded as the inefficiency of regulation and supervision systems, the lack of air quality monitoring systems and technology, particularly in industrial cities rather than Tehran, and the lack of continual feedback and investigations on the efficiency of regulation. Providing such an up-to-date report can bring opportunities for international collaboration, which is essential in addressing air pollution worldwide. We suggest that a way forward could be more focused on conducting systematic reviews using scientometric methods to show an accurate picture and trend in air pollution and its association in Iran, implementing an integrated approach for both climate change and air pollution issues, collaborating with international counterparts to share knowledge, tools, and techniques.