Introduction.Paenibacillusspecies are saprophytes widely distributed in nature and rarely associated with overt human infection. Most cases have been described in people with important comorbidities and/or immunodepression. We report here what is, to the best of our knowledge, the first documented case of human disease due toPaenibacillus silvae, so far considered an exclusively environmental micro-organism.Case presentation.A 57-year-old female patient was referred to our Unit after a 2 month history of remittent fever. Upon admission, a septic state and bacteraemia were revealed;P. sylvaewas identified by 16S rRNA gene amplification and sequencing with matrix-assisted laser desorption/ionization-time of flight MS. The patient became afebrile after 9 days of antibiotic treatment and was completely cured after a 2 week regimen with intravenous amoxicillin-clavulanate plus oral doxycycline.Conclusion.The patient did not report any previous episode of infection. Most of the well-known risk factors toPaenibacillusbacteraemia, i.e. invasive procedures, use of intravenous drugs and foreign bodies, could be excluded, although her immune system was probably impaired due to obesity and heavy smoking. We suggest that the isolation of bacteria belonging to the genusPaenibacillusshould not be disregarded, since there is accumulating evidence that these organisms may cause disease even in immunocompetent subjects.