In this paper, we focus on the link between thinking in opposites and creativity. Thinking in opposites requires an intuitive, productive strategy, which may enhance creativity. Given the importance of creativity for the well-being of individuals and society, finding new ways to enhance it represents a valuable goal in both professional and personal contexts. We discuss the body of evidence that exists concerning the importance of the first representation of the structure of a problem to be solved, which determines the baseline representation and sets limits on the area within which a problem solver will explore. We then review a variety of interventions described in the literature on creativity and insight problem solving that were designed to overcome fixedness and encourage people to move away from stereotypical solutions. Special attention is paid to the research carried out in the context of problem solving, which provides evidence that prompting people to “think in opposites” is beneficial. We suggest that an extended investigation of the effects of this strategy in various types of tasks related to creativity is an interesting line of research to follow. We discuss the rationale supporting this claim and identify specific questions, both theoretical and methodological, for future research to address.