Take Home MessageLithotripsy with Ho:YAG laser is the current gold standard for stones in the upper urinary tract (UUT). Thulium fiber laser (TFL) has the potential to be more efficient than and as safe as Ho:YAG. We found that TFL and Ho:YAG lithotripsy were comparable in terms of their stone-free rate and safety for treatment of UUT lithiasis. A cumulative stone size of 1–2 cm could be an argument for using TFL rather than Ho:YAG.