The use of guided wave-based Ultrasonic Testing (UT) for monitoring Polyethylene (PE) pipes is mostly restricted to detecting defects in welded zones, despite its diversified success in monitoring metallic pipes. PE’s viscoelastic behavior and semi-crystalline structure make it prone to crack formation under extreme loads and environmental factors, which is a leading cause of pipeline failure. This state-of-the-art study aims to demonstrate the potential of UT for detecting cracks in non-welded regions of natural gas PE pipes. Laboratory experiments were conducted using a UT system consisting of low-cost piezoceramic transducers assembled in a pitch-catch configuration. The amplitude of the transmitted wave was analyzed to study wave interaction with cracks of different geometries. The frequency of the inspecting signal was optimized through wave dispersion and attenuation analysis, guiding the selection of third- and fourth- order longitudinal modes for the study. The findings revealed that cracks with lengths equal to or greater than the wavelength of the interacting mode were more easily detectable, while smaller crack lengths required greater crack depths for detection. However, there were potential limitations in the proposed technique related to crack orientation. These insights were validated using a finite element-based numerical model, confirming the potential of UT for detecting cracks in PE pipes.