Background: HIV is a chronic disease with a profound social impact due to its strong ties with sexual and societal stigmatized behavior, such as illegal drug use and sexual promiscuity. Depression is one of the major disabling factors in chronic illnesses. Depression and anxiety disorders are more common among people living with HIV than the non-infected individuals. This study aimed to determine the prevalence of depression and its associated factors among people living with HIV/AIDS in Bangladesh.Methods: This cross-sectional study, which took place in Dhaka, Bangladesh, from July to December 2020, included 338 HIV-positive people. The method used was a simple random sampling technique. The Beck Depression Inventory assessed depression in HIV-positive people (BDI).Results: More than 62 percent of the 338 people surveyed had severe depression, 30.5 percent had moderate depression, 5.6 percent had mild depression, and 1.8 percent had no depression. Age, being a male, being married, and having a low monthly income were all significant predictors of depression.Conclusions: This study found that depressive symptoms are highly prevalent among HIV-positive patients in Bangladesh. The authors recommend that health care providers address depressive disorders for people with HIV/ AIDS comprehensively.