The incidence of lung cancer has seen a significant increase in recent times, leading to a rise in fatalities. The detection of pulmonary nodules from CT images has emerged as an effective method to aid in the diagnosis of lung cancer. Ensuring information security holds utmost significance in the detection of nodules, with particular attention given to safeguarding patient privacy within the context of the Internet of Things (IoT). In this regard, migration learning emerges as a potent technique for preserving the confidentiality of patient data. Firstly, we applied several data-preprocessing steps such as lung segmentation based on K-Means, denoising methods, and lung parenchyma extraction through a dedicated medical IoT network. We used the Microsoft Common Object in Context (MS-COCO) dataset to pre-train the detection framework and fine-tuned it with the Lung Nodule Analysis 16 (LUNA16) dataset to adapt to nodule detection tasks. To evaluate the effectiveness of our proposed pipeline, we conducted extensive experiments that included subjective evaluation of detection results and quantitative data analysis. The results of these experiments demonstrated the efficacy of our approach in accurately detecting pulmonary nodules. Our study provides a promising framework for trustworthy pulmonary nodule detection on lung parenchyma images using a secured hyper-deep algorithm, which has the potential to improve lung cancer diagnosis and reduce fatalities associated with it.