The characteristics of health professionals and their understanding of person-centeredness may have important implications for the development of person-centered practice in specific care settings. In this study, we characterized the perceptions of the person-centered practice of a multidisciplinary team of health professionals working in the internal medicine inpatient unit of a Portuguese hospital. Data were collected using a brief sociodemographic and professional questionnaire and the person-centered practice inventory-staff (PCPI-S), and the effect of different sociodemographic and professional variables on each PCPI-S domain was determined using an analysis of variance (ANOVA). The results showed that a person-centered practice was positively perceived in the major constructs ofprerequisites(M = 4.12; SD = 0.36),the practice environment(M = 3.50; SD = 0.48), andperson-centered process(M = 4.08; SD = 0.62) domains. The highest scored construct wasdeveloped interpersonal skills(M = 4.35; SD = 0.47), and the lowest wassupportive organization systems(M = 3.08; SD = 0.80). Gender was found to influence the perceptions ofknowing self(F(2,75) = 3.67,p= 0.03, partial η2= 0.089) andthe physical environment(F(2,75) = 3.63,p= 0.03, partial η2= 0.088), as was profession onshared decision-making systems(F(2,75) = 5.38,p< 0.01, partial η2= 0.125) andcommitment to the job(F(2,75) = 5.27,p< 0.01, partial η2= 0.123), and the educational level on beingprofessionally competent(F(1,75) = 4.99,p= 0.03, partial η2= 0.062) and havingcommitment to the job(F(2,75) = 4.49,p= 0.04, partial η2= 0.056). In addition, the PCPI-S proved to be a reliable instrument for characterizing healthcare professionals’ perceptions of the person-centeredness of care in this context. Identifying personal and professional variables that influence these perceptions could provide a starting point for defining strategies to move practice toward person-centeredness and for monitoring changes in healthcare practice.