The rapidly spreading COVID-19 disease had already infected more than 190 countries. As a result of this scenario, nations everywhere monitored confirmed cases of infection, cures, and fatalities and made predictions about what the future would hold. In the event of a pandemic, governments had set limit rules for the spread of the virus and save lives. Multiple computer methods existed for forecasting epidemic time series. Deep learning was one of the most promising methods for time-series prediction. In this research, we propose a model for predicting the spread of COVID-19 in Egypt based on deep learning sequence-to-sequence regression, which makes use of data on the population mobility reports. The presented model utilized a new combined dataset from two different sources. The first source is Google population mobility reports, and the second source is the number of infected cases reported daily “world in data” website. The suggested model could predict new cases of COVID-19 infection within 3–7 days with the least amount of prediction error. The proposed model achieved 96.69% accuracy for 3 days of prediction. This study is noteworthy since it is one of the first trials to estimate the daily influx of new COVID-19 infections using population mobility data instead of daily infection rates.