Angelica keiskeiis a perennial plant, belonging to the Apiaceae family and originating from Japan. This plant has been reported to act as a diuretic, analeptic, antidiabetic, hypertensive, tumor, galactagogue, and laxative. The mechanism of action ofA. keiskeiis not known, but previous studies have suggested that it may act as an antioxidant. In this work, we usedDrosophila melanogasterto evaluate the impact ofA. keiskeion lifespan and healthspan and its potential anti-aging mechanism by conducting multiple assays on three fly strains:w1118,chico, and JIV. We observed that the extract extended lifespan and improved healthspan in a sex- and strain-dependent manner.A. keiskeiextended lifespan and improved reproductive fitness in female flies and either had no effect or decreased survival and physical performance in males. The extract protected against the superoxide generator paraquat in both sexes. These sex-specific effects suggest thatA. keiskeimay act through age-specific pathways such as the insulin and insulin-like growth factor signaling (IIS) pathways. Upon examination, we found that the increased survival ofA. keiskei-fed females was dependent on the presence of the insulin receptor substratechico, supporting the role of IIS in the action ofA. keiskei.