In this paper, we are concerned with polynomials that are orthogonal with respect to the singularly perturbed Freud weight functions. By using Chen and Ismail’s ladder operator approach, we derive the difference equations and differential-difference equations satisfied by the recurrence coefficients. We also obtain the differential-difference equations and the second-order differential equations for the orthogonal polynomials, with the coefficients all expressed in terms of the recurrence coefficients.