ObjectiveDuring the past decade, the concept of complete mesocolic excision (CME) has been developed in an attempt to minimize recurrence for right-sided colon cancer. This study aims to compare outcomes of robotic versus laparoscopic right hemicolectomy with CME for right-sided colon cancer.MethodsWe performed a retrospective multicenter propensity score matching study. From July 2016 to July 2021, 382 consecutive patients from different Chinese surgical departments were available for inclusion out of an initial cohort of 412, who underwent robotic or laparoscopic right hemicolectomy with CME. Data of all patients were retrospectively collected and reviewed. Of these, 149 cases were performed by a robotic approach, while the other 233 cases were done by laparoscopy. Propensity score matching was applied at a ratio of 1:1 to compare perioperative, pathologic, and oncologic outcomes between the robotic and the laparoscopic groups (n= 142).ResultsBefore propensity score matching, there were no statistical differences regarding the sex, history of abdominal surgery, body mass index (BMI), American Joint Committee on Cancer (AJCC) staging system, tumor location, and center between groups (p> 0.05), while a significant difference was observed regarding age (p= 0.029). After matching, two comparable groups of 142 cases were obtained with equivalent patient characteristics (p> 0.05). Blood loss, time to oral intake, return of bowel function, length of stay, and complications were not different between groups (p> 0.05). The robotic group showed a significantly lower conversion rate (0%vs. 4.2%,p= 0.03), but a longer operative time (200.9 minvs. 182.3 min,p <0.001) and a higher total hospital cost (85,016 RMBvs. 58,266 RMB,p <0.001) compared with the laparoscopic group. The number of harvested lymph nodes was comparable (20.4vs. 20.5,p= 0.861). Incidence of complications, mortality, and pathologic outcomes were similar between groups (p> 0.05). The 2-year disease-free survival rates were 84.9% and 87.1% (p= 0.679), and the overall survival rates between groups were 83.8% and 80.7% (p= 0.943).ConclusionDespite the limitations of a retrospective analysis, the outcomes of robotic right hemicolectomy with CME were comparable to the laparoscopic procedures with fewer conversions to open surgery. More clinical advantages of the robotic surgery system need to be further confirmed by well-conducted randomized clinical trials with large cohorts of patients.