BackgroundBipolar affective disorder (BAD) is a common severe mental health condition with a relapsing course that may include periods of hospital re-admissions. With recurrent relapses and admissions, the course, prognosis, and patient’s overall quality of life can be affected negatively. This study aims to explore the rates and clinical factors associated with re-admission among individuals with BAD.MethodThis study used data from a retrospective chart review of all records of patients with BAD admitted in 2018 and followed up their hospital records for four years till 2021 at a large psychiatric unit in Uganda. Cox regression analysis was used to determine the clinical characteristics associated with readmission among patients diagnosed with BAD.ResultsA total of 206 patients living with BAD were admitted in 2018 and followed up for four years. The average number of months to readmission was 9.4 (standard deviation = 8.6). The incidence of readmission was 23.8% (n= 49/206). Of those readmitted during the study period, 46.9% (n= 23/49) and 28.6% (n= 14/49) individuals were readmitted twice and three times or more, respectively. The readmission rate in the first 12 months following discharge was 69.4% (n= 34/49) at first readmission, 78.3% (n= 18/23) at second readmission, and 87.5% (n= 12/14) at third or more times. For the next 12 months, the readmission rate was 22.5% (n= 11/49) for the first, 21.7% (n= 5/23) for the second, and 7.1% (n= 1/14) for more than two readmissions. Between 25 and 36 months, the readmission rate was 4.1% (n= 2/49) for the first readmission and 7.1% (n= 1/14) for the third or more times. Between 37 and 48 months, the readmission rate was 4.1% (n= 2/49) for those readmitted the first time. Patients who presented with poor appetite and undressed in public before admission were at increased risk of being readmitted with time. However, the following symptoms/clinical presentations, were protective against having a readmission with time, increased number of days with symptoms before admission, mood lability, and high energy levels.ConclusionThe incidence of readmission among individuals living with BAD is high, and readmission was associated with patients’ symptoms presentation on previous admission. Future studies looking at BAD using a prospective design, standardized scales, and robust explanatory model are warranted to understand causal factors for hospital re-admission and inform management strategies.