Key PointsQuestionIn infants and children treated for growth failure or faltering, moderate or severe wasting, or edema, which postdischarge interventions are helpful in improving outcomes?FindingsThis systematic review, which included 8 intervention studies from 7 countries with 5965 participants, found that biomedical, cash transfer, and integrated interventions may improve certain outcomes in children after treatment for acute malnutrition.MeaningGiven limited evidence on the efficacy of interventions to improve postdischarge outcomes following nutritional treatment for moderate or severe acute malnutrition, additional research on the effectiveness and operational feasibility is warranted to inform global guidance.