ObjectiveThis review will systematically examine and synthesize existing evidence of the effectiveness of ergonomic interventions in preventing work-related musculoskeletal disorders in agricultural workers.IntroductionAgricultural workers are at particular risk of developing musculoskeletal disorders due to the nature of their activities and work conditions. Ergonomic interventions designed to prevent work-related musculoskeletal disorders among agricultural workers can benefit their health and productivity.Inclusion criteriaThe review will consider quantitative study designs. These studies should be about agricultural workers who were involved in occupational situations that might contribute to musculoskeletal disorders.MethodsThe databases including PubMed, CINAHL, Cochrane Central Register of Controlled Trials, Scopus and grey literature will be searched to identify published and unpublished studies reported in English and other languages from 1991 onwards. At least two independent reviewers will screen titles and abstracts and assess the selected full texts against certain inclusion criteria. The identified studies will be assessed for methodological quality using JBI critical appraisal instruments. Data will be extracted, and the effectiveness of the interventions will be determined. Where possible, data will be pooled in a meta-analysis. Data from heterogeneous studies will be reported narratively. The GRADE approach will be used to assess the quality of evidence.Systematic review registration number:PROSPERO CRD42022321098