Soda lakes are productive natural ecosystems with substantial economic and non-economic values. Currently, they are facing considerable environmental threats that can lead to further degradation. The objective of this study was to investigate comparative spatiotemporal variations of physicochemical properties of four Ethiopian soda lakes in comparison with their historical data. Central (open-water) sampling sites were selected from four Ethiopian soda lakes: Arenguade, Beseka, Chittu and Shala. Water samples were collected from open sampling stations from January to December 2020 and analyzed at Limnology laboratory of Addis Ababa University. The geographical position of each lake was determined by means of Global Positioning System (GPS). All physicochemical factors exhibited significant differences between seasons (ANOVA, P < 0.05), except salinity in Lake Shala. The concentrations of physicochemical parameters were generally high during the dry seasons in the studied lakes due to the low incidence of rainfall, caused by recurrent drought, resulting in higher evapotranspiration rates as they are characterized by a long dry season. Lakes Arenguade and Beseka showed considerable decrease in conductivity, alkalinity and salinity, compared to data from the 1960s and 1990s, which might be attributed to dilution effect. The same parameters show slightly increasing trend in Lake Arenguade which might be due to high evaporation rate. In general, the physicochemical parameters of the study lakes showed temporal variations, which could be attributed to the dilution effect, evaporation, and hydrological characteristics of the Ethiopian Rift Valley. In the face of climate change and recurring droughts, in the Ethiopian Rift Valley, the outcomes of this study might be used as input for the long-term planning, of water resources management and devising mitigation strategies.