Wound healing is one of the most important issues in clinical and scientific research. The healing process is complex and requires many agents to overcome in a short duration. A recent class of porous materials called metal-organic frameworks (MOFs) has great potential towards improving wound healing. This is attributed to their well-designed structures with large surface areas amenable to cargo loading and adjustable pore size ready for biological implementations. MOFs are assembled by several metal centers and organic linkers. In particular, metal ions can be released from MOFs when they are degraded in the biological environment. This endows MOF-based systems with dual functions to typically shorten the healing duration. This work focuses on using MOFs with different metal centers such as copper (Cu), zinc (Zn), cobalt (Co), magnesium (Mg), and zirconium (Zr) for healing diabetic wounds as one of the most required clinical issues to be resolved. By figuring out the presented examples of this work, several potential research ideas can emerge to explore new porous materials or even new MOFs for more control over the healing process.