Objectives:Sensation seeking (SS) is associated with engaging in risk behaviors and it is also positively correlated with engaging in physical activity and building beneficial personality resources for coping processes. This study investigates the role of SS in building resiliency and the risk of tobacco and alcohol use.Methods:A total of 649 adolescents, who either practice or do not practice sports, took part in this study. Participants completed a set of questionnaires which verify level of: SS, resiliency, tobacco and alcohol use.Results:No statistically significant gender- or sports-related differences were observed on the tobacco and alcohol use, as well as for SS according to the ANOVA results. Furthermore, mediation analysis showed that the effect of SS on tobacco and alcohol use through resiliency was significant for the female PE and the male athlete group.Conclusion:Higher influence of SS on resiliency was noted in the male athlete group, and in this case resiliency was a factor protecting against tobacco use. Engaging in sports fosters resiliency, the mechanisms underlying the development of resiliency seem to be aided by SS.