Members of theTaCKXgene family (GFMs) encode the cytokinin oxygenase/dehydrogenase enzyme (CKX), which irreversibly degrades cytokinins in the organs of wheat plants; therefore, these genes perform a key role in the regulation of yield-related traits. The purpose of the investigation was to determine how expression patterns of these genes, together with the transcription factor-encoding geneTaNAC2-5A, and yield-related traits are inherited to apply this knowledge to speed up breeding processes. The traits were tested in 7 days after pollination (DAP) spikes and seedling roots of maternal and paternal parents and their F2progeny. The expression levels of most of them and the yield were inherited in F2from the paternal parent. Some pairs or groups of genes cooperated, and some showed opposite functions. Models of up- or down-regulation ofTaCKXGFMs andTaNAC2-5Ain low-yielding maternal plants crossed with higher-yielding paternal plants and their high-yielding F2progeny reproduced gene expression and yield of the paternal parent. The correlation coefficients betweenTaCKXGFMs,TaNAC2-5A, and yield-related traits in high-yielding F2progeny indicated which of these genes were specifically correlated with individual yield-related traits. The most common was expressed in 7 DAP spikesTaCKX2.1, which positively correlated with grain number, grain yield, spike number, and spike length, and seedling root mass. The expression levels ofTaCKX1orTaNAC2-5Ain the seedling roots were negatively correlated with these traits. In contrast, the thousand grain weight (TGW) was negatively regulated byTaCKX2.2.2,TaCKX2.1, andTaCKX10in 7 DAP spikes but positively correlated withTaCKX10andTaNAC2-5Ain seedling roots. Transmission ofTaCKXGFMs andTaNAC2-5Aexpression patterns and yield-related traits from parents to the F2generation indicate their paternal imprinting. These newly shown data of nonmendelian epigenetic inheritance shed new light on crossing strategies to obtain a high-yielding F2generation.