Hydrazone compounds represent an important area of research that includes, among others, synthetic approaches and biological studies. A series of 17 hydrazones have been synthesized by mechanochemical means. The fragments chosen were phenolic and furanyl aldehydes coupled with 12 heterocyclic hydrazines or hydrazinamides. All compounds can be obtained quantitatively when operating on a planetary ball mill and a maximum reaction time of 180 min (6 cycles of 30 min each). Complete spectroscopic analyses of hydrazones revealed eight compounds (3–5,8–11,16) present in one geometric form, six compounds (1,2,13–15) present in two isomeric forms, and three compounds (6,7,12) where one rotation is restricted giving rise to two different forms. The single crystal X-ray structure of one of the hydrazones bearing the isoniazid fragment (8) indicates a crystal lattice consisting of two symmetry-independent molecules with different geometries. All compounds obtained were tested for anti-infectious and antibacterial activities. Four compounds (1,3,5and8) showed good activity againstMycobacterium tuberculosis, and one (7) was very potent againstStaphylococcus aureus. Most interesting, this series of compounds displayed very promising antileishmanial activity. Among all, compound9exhibited an IC50value of 0.3 µM on theLeishmania donovaniintramacrophage amastigote in vitro model and a good selectivity index, better than miltefosine, making it worth evaluating in vivo.