(1) Background: This study aimed to determine the effect of repeated pre-polymerization heating on the color and translucency of a one-shaded resin-based composite and to evaluate whether the heating cycles affect its color stability. (2) Methods: Fifty-six samples of 1-mm thickness were fabricated from Omnichroma (OM) after applying different heating cycles (for one, five, and ten times at 45 °C) before polymerization (n= 14/group) and afterwards were stained with a yellow dye solution. CIE L*, a*, b*, C*, h° coordinates were recorded, and color differences, whiteness, and translucency were calculated, before and after staining. (3) Results: Heating cycles significantly influenced the color coordinates, WID00, and TP00of OM being higher after one heating cycle and decreasing as the number of heating cycles increased. The color coordinates, WID, and TP00after staining significantly differed for each group. The color and whiteness differences calculated after staining exceeded the acceptability thresholds for all groups. The color and whiteness variations after staining were clinically unacceptable. (4) Conclusions: Repeated pre-polymerization heating induces a clinically acceptable color and translucency change to OM. Although the color changes resulting after staining are clinically unacceptable, increasing the number of heating cycles up to ten times slightly reduces the color differences.