Many enzymes work
in tandem with small molecule cofactors,
which
have inspired organocatalyst designs. Chemical modification of cofactor
scaffolds has increased organocatalytic reactivity and reaction scope.
This synopsis presents a selection of recent advances in the use of
cofactors (native and mimics) in organocatalysis and biocatalysis.
We aim to highlight the benefits of combining fundamental knowledge
gained in both bio- and organo-catalysis for asymmetric biocatalysis.