Background: Third-generation transcatheter heart valves (THVs) are designed to improve outcomes. Data on the new intra-annular self-expanding NAVITOR are scarce. Aims: The aim of this analysis was to compare outcomes between the PORTICO and the NAVITOR systems. Methods: Data from 782 patients with severe native aortic stenosis treated with PORTICO (n= 645) or NAVITOR (n= 137) from 05/2012 to 09/2022 were evaluated. The clinical and hemodynamic outcomes of 276 patients (PORTICO,n= 139; NAVITOR,n= 137) were evaluated according to VARC-3 recommendations. Results: Rates of postprocedural more-than-mild paravalvular leakage (PVL) were significantly lower for NAVITOR than for PORTICO (7.2% vs. 1.5%,p= 0.041). In addition, severe bleeding rates (27.3% vs. 13.1%,p= 0.005) and major vascular complications (5.8% vs. 0.7%,p= 0.036) were lower in the NAVITOR group. The mean gradients (7 vs. 8 mmHg,p= 0.121) and calculated aortic valve areas (1.90 cm2vs. 1.99 cm2,p= 0.235) were comparable. Rates of PPI were similarly high in both groups (15.3 vs. 21.6,p= 0.299). Conclusions: The NAVITOR demonstrated favorable in-hospital procedural outcome data, with lower rates of relevant PVL, major vascular complications, and severe bleeding than its predecessor the PORTICO and preserved favorable hemodynamic outcomes.