Panstrongylusis a Neotropical taxa of 16 species, some more widespread than others, that act as vectors ofTrypanosoma cruzi, the etiologic agent of Chagas disease (CD). This group is associated with mammalian reservoir niches. There are few studies of the biogeography and niche suitability of these triatomines. Using zoo-epidemiological occurrence databases, the distribution ofPanstrongyluswas determined based on bioclimatic modelling (DIVA GIS), parsimonious niche distribution (MAXENT), and parsimony analysis of endemic species (PAE). Through 517 records, a wide presence ofP. geniculatus,P. rufotuberculatus,P. lignarius, andP. megistuswas determined and recorded as frequent vectors ofT. cruziin rainforest habitats of 24–30 °C. These distributions were modeled with AUC >0.80 and <0.90, as well as with the seasonality of temperature, isothermality, and precipitation as relevant bioclimatic variables. Individual traces for each taxon inPanstrongylus—1036 records—showed widely dispersed lines for frequent vectorsP. geniculatus,P. lignarius,P. rufotuberculatus, andP. megistus. Other occasional vectors showed more restricted dispersal, such asP. howardi,P. humeralis,P. lenti,P. lutzi,P. tupynambai,P. noireaiui, andP. chinai. Areas of defined environmental variation, geological change, and trans domain fluid fauna, such as the American Transition Zone and the Pacific Domain of Morrone, had the highestPanstrongylusdiversity. Pan-biogeographic nodes appear to be areas of the greatest species diversity that act as corridors connecting biotopes and allowing fauna migration. Vicariance events in the geologic history of the continent need to be investigated. The geographical distribution ofPanstrongylusoverlapped with CD cases andDidelphis marsupialis/Dasypus novemcinctuspresence, two important reservoirs in Central and South America. The information derived from the distribution ofPanstrongylusprovides knowledge for surveillance and vector control programs. It would increase information on the most and less relevant vector species of this zoonotic agent, for monitoring their population behavior.