We designed and executed
an expedient synthesis of a complex analogue
of the potent immunosuppressive natural product brasilicardin A. Our
successful synthesis featured application of our recently developed
MHAT-initiated radical bicyclization, which delivered the targeted,
complex analogue in 17 steps in the longest linear sequence. Unfortunately,
this analogue showed no observable immunosuppressive activity, which
speaks to the importance of the structural and stereochemical elements
of the natural core scaffold.