Key PointsQuestionWhat are the probable health consequences of 3 US Supreme Court decisions in 2022 that invalidated COVID-19 workplace protections, voided state laws on handgun-carry restrictions, and revoked the constitutional right to abortion?FindingsIn this decision analytical modeling study, the model projected that the Supreme Court ruling to invalidate COVID-19 workplace protections was associated with 1402 deaths in early 2022. The model also projected that the court’s decision to end handgun-carry restrictions will result in 152 additional firearm-related deaths annually, and that its decision to revoke the constitutional right to abortion will result in 6 to 15 deaths and hundreds of cases of peripartum morbidity each year.MeaningThese findings suggest that over a decade, the 3 Supreme Court decisions examined here will contribute to the loss of nearly 3000 US lives and possibly many more.