AbstractDisease Models & Mechanisms (DMM) is delighted to announce that the winners of the DMM Outstanding Paper Prize 2022 are Tamihiro Kamata for their Research Article (titled ‘Statins mediate anti- and pro-tumourigenic functions by remodelling the tumour microenvironment’), and Jennifer K. Sargent and Mark A. Warner for their Resource Article (titled ‘Genetically diverse mouse platform to xenograft cancer cells’). The two prizes of £1000 are awarded to the first author(s) of the papers that are judged by the journal's Editors to be the most outstanding contribution to the journal that year.