Objectives: This study describes the effects of interval hypoxic training and electrical muscle stimulation (EMS) technology on human productivity with the following metrics: biochemical indices, cognitive abilities, changes in oxygenated (HbO) and deoxygenated (Hb) hemoglobin concentrations over the prefrontal cortex, and functional connectivity via electroencephalography (EEG). Methods: All measurements according to the described technology were made before the start of training and one month later, right after it ended. The study involved middle-aged Indo-European men. Specifically, there were 14, 15, and 18 participants in the control, hypoxic, and EMS groups, respectively. Results: EMS training improved reactions and nonverbal memory but decreased attention scores. Functional connectivity decreased in the EMS group while it increased in the hypoxic group. A result of the interval normobaric hypoxic training (IHT) was significantly improved contextual memory, with ap-value = 0.08. Conclusions: It was found that EMS training is more likely to cause stress on the body than positively affect cognitive functions. At the same time, interval hypoxic training can be considered a promising direction for increasing human productivity. The data obtained during the study can also help in the timely diagnosis of insufficient or overestimated indicators of biochemistry.