Even though most personality features are moderately stable throughout life, changes can be observed, which influence one’s behavioral patterns. A variety of subjective assessments can be performed to track these changes; however, the subjective characteristic of these assessments may lead to questions about intentions and values. The use of neuroimaging techniques may aid the investigation of personality traits through a more objective lens, overcoming the barriers imposed by confounders. Here, neurocircuits associated with changes in personality domains were investigated to address this issue. Cortical systems involved in traits such as extraversion and neuroticism were found to share multiple components, as did traits of agreeableness and conscientiousness, with these four features revolving around the activation and structural integrity of the medial prefrontal cortex (mPFC). The attribute of openness appears scattered throughout cortical and subcortical regions, being discussed here as a possible reflection of intent, at the same time modulating and being governed by other traits. Insights on how systems operate on personality may increase comprehension on factors acting on the evolution, development, and consolidation of personality traits through life, as in neurocognitive disorders.