BackgroundProfessional autonomy is essential in expanding the scope of nursing practice and has been recognized as a top nursing priority.ObjectiveThis study aims to assess Saudi nurses’ autonomy level in critical care settings and examine the influence of sociodemographic and clinical characteristics on their autonomy level.MethodsA correlational design and a convenience sampling approach were used to recruit 212 staff nurses from five Saudi governmental hospitals in Jouf region of Saudi Arabia. The data were collected through a self-administered questionnaire composed of two sections, including sociodemographic characteristics and the Belgen autonomy scale. The Belgen autonomy scale used in this study measures nurses’ autonomy levels and consists of 42 items rated on an ordinal scale. The scale’s minimum score of 1 indicates nurses with no authority, while the maximum score of 5 indicates nurses with full authority.ResultsDescriptive statistics revealed that nurses in the sample had a moderate overall work autonomy (M = 3.08), with higher autonomy in patient care decisions (M = 3.25) compared to unit operations decisions (M = 2.91). Nurses had the highest level of autonomy in tasks related to preventing patient falls (M = 3.84), preventing skin breakdown (M = 3.69), and promoting health activities (M = 3.62), while they had the lowest level of autonomy in ordering diagnostic tests (M = 2.27), determining the day of discharge (M = 2.61), and planning the unit’s annual budget (M = 2.22). The multiple linear regression model (R2 = 0.32, F (16, 195) = 5.87, p < .001) showed that education level and years of experience in critical care settings were significantly related to nurses’ work autonomy.ConclusionSaudi nurses in acute care settings have moderate professional autonomy, with higher autonomy in making patient care decisions than unit operations decisions. Investing in nurses’ education and training could increase their professional autonomy, leading to improved patient care. Policymakers and nursing administrators can use the study’s results to develop strategies that promote nurses’ professional development and autonomy.