Introduction.Infections forbyMyroidesspp. can lead to significant morbidity and mortality, particularly in immunocompromised patients with underlying co-morbidities. Recent reports have highlighted its intrinsic and acquired drug resistance, making it a particularly challenging infectious agent to combat.Methods.Myroidesspp. isolated and reported in clinically significant urine samples were considered for the study. Identification of the organism was done via the VITEK 2C system. Antibiotic susceptibility testing was done using both manual and automated methods following Clinical and Laboratory Standards Institute (CLSI) guidelines. Existing literature was searched on MEDLINE using PubMed.Results.We present a series of five catheter-associated urinary tract infections due toMyroides odoratimimus, with sensitivity to only minocycline. This is the first case from Western India, and the third case in the existing literature that showsMyroidessensitivity only to minocycline. Our literature review is the first to systematically describe contributory factors to infection, allowing us to devise a clinically relevant tool that delineates contributory factors and efficacious drugs inMyroidesspp.infection.Conclusion.Myroidesspp.infections, previously considered rare and opportunistic, need cognizance and diagnostic suspicion especially in particular associated conditions.