The study investigated the antioxidant effects of roastedCudrania tricuspidata(C. tricuspidata) fruits by comparing them with unroastedC. tricuspidatafruits. The results showed that the roastedC. tricuspidatafruits (150 °C, 120 min) exhibited significantly higher antioxidant activity, especially in terms of anti-inflammatory effects, than the unroasted fruits. Interestingly, there is a high correlation between the color of the roasted fruit and the antioxidant activity. Heating disrupts cells and deactivates endogenous oxidative enzymes, leading to an increase in flavonoid content. Moreover, heat treatment may also interfere with plant metabolism, thereby influencing flavonoid content. Moreover, an HPLC analysis of roasted fruits in our study showed that the increase in antioxidant activity was attributed to the increase in flavan-3-ols and phenolic acids in the roastedC. tricuspidatafruits. To the best of our knowledge, this is the first time the antioxidant activity and anti-inflammation of roastedC. tricuspidatafruits was studied. The study concluded that roastedC. tricuspidatafruits could be a valuable natural source of antioxidants for various food and medicinal applications.