Campylobacterspp. is a gram-negative bacillus that causes infectious enteritis and consists of several species, includingCampylobacter jejuni,Campylobacter coli, andCampylobacter fetus. AlthoughC. jejuniandC. colicause infectious enteritis primarily in immunocompetent hosts,C. fetuscauses extraintestinal infections such as septicemia, meningitis, and perinatal infections in immunocompromised hosts, as well as myopericarditis in rare cases. Only a few cases of infectious myo(peri)carditis associated withC. coliin immunocompetent hosts have been reported. These studies concentrated on antecedentC. colienterocolitis and never demonstrated a positive culture in the pericardial fluid.A 72-year-old Japanese man presented with a 2-week fever, cough, and vomiting lasting. He was on hemodialysis for polycystic kidney disease, as well as medication for diabetes and hypertension. A chest computed tomography (CT) scan and a transthoracic echocardiogram revealed bilateral pleural fluid and large pericardial fluid at the time of admission.C. coliwas identified from blood culture samples and blood-tinged pericardial fluid. He was successfully treated with antibacterial chemotherapy as well as pericardial fluid drainage and was discharged from the hospital with no complications.In this case, the presence ofC. coliin the pericardial fluid confirmed the diagnosis ofC. colipericarditis.C. colimay cause septic pericarditis in immunocompromised hosts, despite typically causing only enteritis.