This article explores opportunities to mitigate the performance impact of IOMMU on high-speed network traffic, as used in the Linux kernel. We first characterize IOTLB behavior and its effects on recent Intel Xeon Scalable & AMD EPYC processors at 200 Gbps, by analyzing the impact of different factors contributing to IOTLB misses and causing throughput drop (up to 20% compared to the no-IOMMU case in our experiments). Secondly, we discuss and analyze possible mitigations, including proposals and evaluation of a practical hugepage-aware memory allocator for the network device drivers to employ hugepage IOTLB entries in the Linux kernel. Our evaluation shows that using hugepage-backed buffers can completely recover the throughput drop introduced by IOMMU. Moreover, we formulate a set of guidelines that enable network developers to tune their systems to avoid the “IOTLB wall”,i.e., the point where excessive IOTLB misses cause throughput drop. Our takeaways signify the importance of having a call to arms to rethink Linux-based I/O management at higher data rates.