Metal aromatic substances play a unique and important role in both experimental and theoretical aspects, and they have made tremendous progress in the past few decades. The new aromaticity system has posed a significant challenge and expansion to the concept of aromaticity. From this perspective, based on spin-polarized density functional theory (DFT) calculations, we systematically investigated the doping effects on the reduction reactions of N2O catalyzed by CO for M13@Cu42(M = Cu, Co, Ni, Zn, Ru, Rh, Pd, Pt) core–shell clusters from aromatic-like inorganic and metal compounds. It was found that compared with the pure Cu55cluster, the strong M–Cu bonds provide more structural stability for M13@Cu42clusters. Electrons that transferred from the M13@Cu42to N2O promoted the activation and dissociation of the N–O bond. Two possible reaction modes of co-adsorption (L-H) and stepwise adsorption (E-R) mechanisms over M13@Cu42clusters were thoroughly discovered. The results showed that the exothermic phenomenon was accompanied with the decomposition process of N2O via L-H mechanisms for all of the considered M13@Cu42clusters and via E-R mechanisms for most of the M13@Cu42clusters. Furthermore, the rate-limiting step of the whole reactions for the M13@Cu42clusters were examined as the CO oxidation process. Our numerical calculations suggested that the Ni13@Cu42cluster and Co13@Cu42clusters exhibited superior potential in the reduction reactions of N2O by CO; especially, Ni13@Cu42clusters are highly active, with very low free energy barriers of 9.68 kcal/mol under the L-H mechanism. This work demonstrates that the transition metal core encapsulated M13@Cu42clusters can present superior catalytic activities towards N2O reduction by CO.