The developed karst caves may become the seepage channels of heavy metal to the soil and underground water in Southwest China. Therefore, it is necessary to apply effective seepage treatments to the base of heavy metal tailing reservoirs. This paper addressed the high-pressure rotary jet technology and slurry systems used in the seepage treatment of the deep tailing sand of the Shenxiandong tailing pond located in Southwest China. In this study, the factors of fluidity, initial and final setting times, compressive strength, and permeability coefficient of the slurry were conducted. The mechanism analysis was investigated by X-ray diffraction (XRD), scanning electron microscope (SEM), and inductively coupled plasma-mass spectrometry (ICP-MS). Three different types of slurry systems were proposed, and the permeability coefficients of the solidification body following 28 days of curing were less than 1 × 10−7cm/s. The concentrations of Pb and Zn in the slurry system containing bentonite were reduced by 26.2% and 45.7%, respectively. In the presence of slaked lime and fly ash, the concentrations of Pb and Zn could be reduced by 26.8% and 30%, respectively. A total of 2142 high-pressure rotary jet piles were completed by the high-pressure rotary jet method in the field trial. The diffusion radius of these piles was over 1 m. Following 28 days of curing, the solidification body’s compressive strength was 7.45 MPa and the permeability coefficient was 6.27 × 10−8cm/s. Both the laboratory and on-site trials showed that this method produced a good pollution barrier effect, which could prevent the diffusion of heavy metal into the adjacent underground water through the karst caves. It is also an effective way of engineering technology concerning heavy metal pollution control that occurs in tailing ponds.