AbstractStable and efficient high‐power biohybrid light‐emitting diodes (Bio‐HLEDs) using fluorescent proteins (FPs) in photon downconverting filters have not been achieved yet, reaching best efficiencies of 130 lm W−1stable for >5 h. This is related to the rise of the device temperature (70–80 °C) caused by FP‐motion and quick heat‐transmission in water‐based filters, they lead to a strong thermal emission quenching followed by the quick chromophore deactivation via photoinduced H‐transfer. To tackle both issues at once, this work shows an elegant concept of a new FP‐based nanoparticle, in which the FP core is shielded by a SiO2‐shell (FP@SiO2) with no loss of the photoluminescence figures‐of‐merit over years in foreign environments: dry powder at 25 °C (ambient) or constant 50 °C, as well as suspensions in organic solvents. This enables the preparation of water‐free photon downconverting coatings with FP@SiO2, realizing on‐chip high‐power Bio‐HLEDs with 100 lm W−1stable for >120 h. Both thermal emission quenching and H‐transfer deactivation are suppressed, since the device temperature holds <40 °C and remote high‐power Bio‐HLEDs exhibit final stabilities of 130 days compared to reference devices with water‐based FP@SiO2(83 days) and FP‐polymer coatings (>100 h). Hence, FP@SiO2is a new paradigm toward water‐free zero‐thermal‐quenching biophosphors for first‐class high‐power Bio‐HLEDs.