Chronic kidney disease and the need for kidney replacement therapy have increased dramatically in recent decades. Forecasts for the coming years predict an even greater increase, especially in low- and middle-income countries, due to the rise in metabolic and cardiovascular diseases and the aging population. Access to kidney replacement treatments may not be available to all patients, making it especially strategic to set up therapy programs that can ensure the best possible treatment for the greatest number of patients. The choice of the “ideal” kidney replacement therapy often conflicts with medical availability and the patient’s tolerance. This paper discusses the pros and cons of various kidney replacement therapy options and their real-world applicability limits.