Simple SummaryChanging environmental parameters with the development of global warming and the growing anthropogenic influence lead to the spread of insect pests in new habitats, abundant in their host plants. While remaining visually undetected, representatives of the hemipteran insect pests in the suborder Sternorrhyncha cause large-scale economic losses. In this review, we consider the main pathogenic superfamilies of the suborder and present new methods of dealing with them that meet the requirements for modern insecticides and take into account the need for the development of insecticides that do not cause global warming. We solve the problem of environmental pollution caused by modern insecticides by proposing the use of oligonucleotide insecticides based on conservative fragments of genomes of insect pests which slow down the emergence of resistance to the applied insecticides. Our proposed approach opens up new horizons for both safe and effective insect pest control.AbstractSternorrhyncha representatives are serious pests of agriculture and forestry all over the world, primarily causing damage to woody plants. Sternorrhyncha members are vectors for the transfer of a large number of viral diseases, and subsequently, the host plant weakens. Additionally, many are inherent in the release of honeydew, on which fungal diseases develop. Today, an innovative approach is needed to create new and effective ways to control the number of these insects based on environmentally friendly insecticides. Of particular relevance to such developments is the need to take into account the large number of organisms living together with insect pests in this group, including beneficial insects. Practically without changing their location on their host plant, they adopted to be more invisible and protected due to their small size, symbiosis with ants, the ability to camouflage with a leaf, and moderately deplete plants and others, rarely leading them to death but still causing substantial economic loss in the subtropics and tropics. Due to the lack of presence in the literature, this review fills in this pesky spot by examining (on the example of distinct species from four superfamilies) the characteristic adaptations for this suborder and the chemical methods of combating these insects that allow them to survive in various environmental conditions, suggesting new and highly promising ways of using olinscides for plant protection against Sternorrhyncha members.