PurposeTo quantify in patients with optic nerve head drusen (ONHD)changes after 1-year observation in: (i) optic disc and (ii) macular optical coherence tomography (OCT) parameters and (iii) the effect of age at enrolment in the study.DesignProspective, cross-sectional observational study using Spectral Domain-OCT (Copernicus; OPTOPOL Technology S.A., Zawiercie, Poland) imaging was carried out in 35 patients with ONHD (age–42.8 ± 19.9 years; males = 15; females = 20) at baseline and after 12 months follow-up.ResultsPatients with ONHD had significant thinning of the surface nerve fibre layer in the central (p= 0.03), superior (p= 0.05) and inferior (p= 0.04) areas; mean ppRNFL thinning (p= 0.0 4) and ppRNFL thinning in the nasal segment (p= 0.028). Retinal thinning in the central (p= 0.001), inner (p= 0.01) and outer (p= 0.002) temporal, outer superior (p= 0.03) and inferior (p= 0.02) areas; borderline ganglion cell layer thinning (p= 0.051) and outer nuclear layer (p= 0.03) thinning in the central retina and outer segment layer thinning nasally (p= 0.01) between the first and the second visit in macula. Correlation of the difference in optic disc and macular parameters with the age at enrolment did not reveal any significance.ConclusionsStatistically detectable thinning of the optic nerve and macula structures occurred already after 12 months. The proximity of optic nerve changes to the vascular arcades can possibly be explained by involvement of retinal vessels in the pathophysiology of ONHD.