ABSTRACTA group of 156 virologists, including American Society of Microbiology journal editors-in-chief, has recently published across three ASM journals a “call for rational discourse” on such important topics as the origin of SARS-CoV-2 and gain of function research (e.g., F. Goodrum et al.,mBio14:e0018823, 2023,https://doi.org/10.1128/mbio.00188-23). Here, I answer the call, arguing that the origin of SARS-CoV-2 is unknown; that continued premature downplaying of a possible laboratory origin, now accompanied by a denial that this was ever so dismissed, undermines public trust in science; and that the benefits from risky gain-of-function research-of-concern are fewer than Goodrum et al. imply.