The shift in work paradigm owing to the implementation of new policies in the developing countries of Southeast Asia to reduce the spread of COVID-19 has created new challenges for both employers and employees. The study aimed to address the lack of extensive research on the effects of psychological, social, and situational factors on the work-from-home shift in Southeast Asia. This study incorporates the job characteristic theory, emphasizing how specific job characteristics influence motivation and performance. The study emphasizes the importance of creating an innovative and supportive work environment, improving digital capabilities, and promoting sustainable development through high-skill jobs to enhance remote employees’ productivity. Valid responses from 288 full-time employees who have the option to work remotely were collected through online survey. The findings indicate that self-discipline, digital capability, and perceived organizational support significantly influence the preference for remote work. Managers should focus on motivating employees, providing support, and establishing a digital infrastructure to maximize productivity. Training and recruitment strategies should adapt to the changing work culture, while social support is crucial for encouraging innovative problem-solving. Trusting employees with autonomy and providing appropriate technologies fosters collaboration, efficiency, and creativity in different work settings.