This meta-analysis examined the associations between five-factor personality model traits and problem gambling. To be eligible for inclusion in the meta-analysis, studies had to provide effect size data that quantified the magnitude of the association between all five personality traits and problem gambling. Studies also had to use psychometrically sound measures. The meta-analysis included 20 separate samples from 19 studies and 32,222 total participants. The results showed that problem gambling was significantly correlated with the five-factor model of personality. The strongest personality correlate of problem gambling was neuroticismr= .31,p= < 0.001, 95%CI[0.17, 0.44], followed by conscientiousnessr= − .28,p= < 0.001, 95%CI[-0.38,-0.17] ), agreeablenessr= − .22,p= < 0.001, 95%CI[-0.34, − 0.10], opennessr= − .17,p= < 0.001, 95%CI[-0.22,-0.12], and extraversionr= − .11,p= .024, 95%CI[-0.20,-0.01]. These results suggest problem gamblers tend to share a common personality profile – one that could provide clues as to the most effective ways to prevent and to treat problem gambling.