In Saudi Arabia, cardiovascular disease (CVD) is one of the main causes of mortality and morbidity. The Kingdom of Saudi Arabia has undergone tremendous socio-economic development and urbanization over the past few decades, which has profoundly changed the lifestyle leading to several risk factors that contribute to the high prevalence of CVD. This systematic review identified significant lifestyle factors associated with CVD risk in order to inform effective interventions to decrease the CVD burden in Saudi Arabia. We researched all published articles and reports evaluating CVD risk factors in Saudi Arabia in the last four years from the following databases: Medline, PubMed, Google Scholar, and Embase. A total of 19 articles and 1 report were included. Physical inactivity was among 69.4% of the population, mostly among Saudi women, and was associated with 1.4-1.5 odds of CVD. Obesity prevalence was 49.6%-57% and was associated with more odds of CVD among women than men (3.3 odds vs. 2.38 odds). More than a third (34.4%) of the Saudi population studied ate unhealthy diets (rich in fat, poor in fibers, less vegetables and fruits, and ultra-processed), which was found to more than triple (almost quadruple) the CVD risks (OR=3.8). Smoking prevalence was 12.2%-26.2% and was more among men. Other factors, such as type 2 diabetes (OR=2.3) and stress (5.4%-16.9%), were also identified as factors.The prevalence of CVD lifestyle-related risk factors is still high in Saudi Arabia, especially physical inactivity, unhealthy diet, obesity, and smoking, which highlights the urgent need for lifestyle modifications and public health campaigns and collaboration among the Saudi government and its partners to effectively improve cardiovascular health in Saudi Arabia.