Rationale & ObjectivePoor dietary patterns and low physical activity levels are important lifestyle-related factors that contribute to negative health outcomes in individuals with chronic kidney disease (CKD). Previous systematic reviews have not explicitly focused on these lifestyle factors, nor undertaken meta-analyses of any effects. We aimed to evaluate the effect of lifestyle interventions (such as diet, exercise, and other lifestyle-related interventions) on the risk factors for and progression of CKD and the quality of life.Study DesignSystematic review and meta-analysisSetting & Study PopulationsIndividuals aged 16 years or older with CKD stages 1 to 5 not requiring kidney replacement therapy.Selection Criteria for StudiesRandomized controlled trials of interventions.Data ExtractionKidney function, albuminuria, creatinine, systolic blood pressure, diastolic blood pressure, body weight, glucose control, and quality of life.Analytical ApproachA random-effects meta-analysis with evidence certainty assessed using GRADE.ResultsSeventy-eight records describing 68 studies were included. Twenty-four studies (35%) were dietary interventions, 23 (34%) exercise, 9 (13%) behavioral, 1 (2%) hydration, and 11 (16%) multiple component. Lifestyle interventions resulted in significant improvements in creatinine (weighted mean difference [WMD], −0.43 mg/dL; 95% CI, −0.74 to −0.11;P= 0.008); 24-hour albuminuria (WMD, −53 mg/24 h; 95% CI, −56 to −50;P< 0.001); systolic blood pressure (WMD, −4.5 mm Hg; 95% CI, −6.7 to −2.4;P< 0.001); diastolic blood pressure (WMD, −2.2 mm Hg; 95% CI, −3.7 to −0.8;P= 0.003); and body weight (WMD, −1.1 kg; 95% CI, −2.0 to −0.1;P= 0.025). Lifestyle interventions did not result in significant changes in the estimated glomerular filtration rate (0.9 mL/min/1.73 m2; 95% CI, −0.6 to 2.3;P= 0.251). However, narrative synthesis indicated that lifestyle intervention resulted in improvements in the quality of life.LimitationsCertainty of the evidence was rated very low for most outcomes, primarily owing to the risk of bias and inconsistency. No meta-analysis was possible for quality-of-life outcomes because of variations in measurement tools.ConclusionsLifestyle interventions seem to positively affect some risk factors for progression of CKD and quality of life.