The mechanisms underlying neuropeptide signaling regulation of lifespan inCaenorhabditis elegans(C. elegans) remain unclear. FRPR-18 is a mammalian orexin/hypocretin-like receptor and modulatesC. elegansarousal behavior by acting as a receptor for FLP-2 neuropeptide signaling, which is also associated with the systemic activation of the mitochondrial unfolded protein response (mitoUPR). Here we report our preliminary findings on the role of thefrpr-18gene in regulating lifespan and healthspan parameters, including stress resistance. Our results showed thatfrpr-18(ok2698)null mutants had a shorter lifespan and reduced survivability against thermal stress and paraquat treatment. On the other hand, loss offlp-2function did not affect lifespan or paraquat tolerance but was necessary for normal thermal stress tolerance. These findings suggest thatfrpr-18could play a role in regulating lifespan and stress resistance, possibly throughflp-2independent or parallel neuropeptide signaling pathways.