Simple SummaryWith climate change exacerbating heat extremes, there is a growing need for sustainable measures that can reduce physiological heat strain. However, public health policies have issued warnings against the use of electric fans and ventilators at ambient temperatures exceeding typical skin temperatures of 35 °C. Aiming to extend previous findings for sedentary persons to moderately exercising individuals, we analyzed the heart rates, sweat rates, and core and skin temperatures recorded in 198 climatic chamber experiments with 3h exposures to treadmill work under widely varying heat stress conditions. Our findings suggest mitigating wind effects at temperatures above 35 °C when humidity is elevated. Moreover, the close agreement of the observed effects with the corresponding wind effects predicted by the Universal Thermal Climate Index (UTCI)demonstrates the potential of theUTCIfor evaluating sustainable strategies of heat stress mitigation for moderately exercising individuals.AbstractIncreasing wind speed alleviates physiological heat strain; however, health policies have advised against using ventilators or fans under heat wave conditions with air temperatures above the typical skin temperature of 35 °C. Recent research, mostly with sedentary participants, suggests mitigating the effects of wind at even higher temperatures, depending on the humidity level. Our study aimed at exploring and quantifying whether such results are transferable to moderate exercise levels, and whether the Universal Thermal Climate Index (UTCI) reproduces those effects. We measured heart rates, core and skin temperatures, and sweat rates in 198 laboratory experiments completed by five young, semi-nude, heat-acclimated, moderately exercising males walking the treadmill at 4 km/h on the level for three hours under widely varying temperature–humidity combinations and two wind conditions. We quantified the cooling effect of increasing the wind speed from 0.3 to 2 m/s by fitting generalized additive models predicting the physiological heat stress responses depending on ambient temperature, humidity, and wind speed. We then compared the observed wind effects to the assessment performed by theUTCI. Increasing the wind speed lowered the physiological heat strain for air temperatures below 35 °C, but also for higher temperatures with humidity levels above 2 kPa water vapor pressure concerning heart rate and core temperature, and 3 kPa concerning skin temperature and sweat rate, respectively. TheUTCIassessment of wind effects correlated positively with the observed changes in physiological responses, showing the closest agreement (r = 0.9) for skin temperature and sweat rate, where wind is known for elevating the relevant convective and evaporative heat transfer. These results demonstrate the potential of theUTCIfor adequately assessing sustainable strategies for heat stress mitigation involving fans or ventilators, depending on temperature and humidity, for moderately exercising individuals.