Plant-microbe interactions play a crucial role in shaping plant growth and development, as well as in mediating plant responses to biotic and abiotic stresses. In this study, we used RNA-seq data to examine the expression profiles ofSlWRKY,SlGRAS, andSlERFgenes during the symbiotic association ofCurvularia lunataSL1 with tomato (Solanum lycopersicum) plants. We also conducted functional annotation analysis by comparative genomics studies of their paralogs and orthologs genes, as well as other approaches, such as gene analysis and protein interaction networks, to identify and characterize the regulatory roles of these TFs in the development of the symbiotic association. We found that more than half of the investigatedSlWRKYgenes exhibited significant upregulation during symbiotic association, includingSlWRKY38,SlWRKY46,SlWRKY19, andSlWRKY51. SeveralSlGRASandSlERFgenes were upregulated, such asSlGLD2,SlGLD1,SlERF.C.5,ERF16, andSlERF.B12. Conversely, a smaller proportion ofSlWRKY,SlGRAS, andSlERFgenes were significantly downregulated during symbiotic association. Furthermore, we investigated the possible roles ofSlWRKY,SlGRAS, andSlERFgenes in hormonal regulation during plant-microbe interactions. We identified several upregulated candidate transcripts likely to be involved in plant hormone signaling pathways. Our findings are consistent with previous studies on these genes, providing further evidence of their involvement in hormonal regulation during plant-microbe interactions. To validate the RNA-seq data accuracy, we performed RT-qPCR analyses of selectedSlWRKY,SlGRAS, andSlERFgenes, which showed similar expression patterns to those observed in the RNA-seq data. These results confirmed the accuracy of our RNA-seq data and provided additional support for the differential expression of these genes during plant-microbe interactions. Taken together, our study provides new insights into the differential expression profiles ofSlWRKY,SlGRAS, andSlERFgenes during symbiotic association withC. lunata, as well as their potential roles in hormonal regulation during plant-microbe interactions. These findings could be useful for guiding future research on the ways in which plants and microbes interact, and may ultimately lead to the creation of better approaches for promoting plant growth under stressful conditions.