BackgroundThe utilization of modern-immunotherapies, notably immune checkpoint inhibitors (ICIs), has increased markedly in patients with metastatic melanoma over the past decade and are recommended as standard treatment. Given their increasing adoption in routine care for melanoma, understanding patient access to immunotherapy and patterns of its use in Texas is crucial as it remains one of the few states without Medicaid expansion and with high rates of the uninsured population. The objectives of this study were to examine the trend in the utilization of immunotherapy and to determine factors associated with immunotherapy utilization among patients with metastatic melanoma in the era of ICIs in Texas.MethodsA retrospective cohort study was conducted using the Texas Cancer Registry (TCR) database. The cohort comprised of adult (≥ 18 years) patients with metastatic melanoma diagnosed between June 2011 and December 2018. The trend in immunotherapy utilization was assessed by determining the proportion of patients receiving immunotherapy each year. The Average Annual Percent Change (AAPC) in immunotherapy utilization was assessed using joinpoint regression, while multivariable logistic regression was used to determine the association between patient characteristics and immunotherapy receipt.ResultsA total of 1,795 adult patients with metastatic melanoma were identified from the TCR. Immunotherapy utilization was higher among younger patients, those with no comorbidities, and patients with private insurance. Multivariable analysis showed that the likelihood of receipt of immunotherapy decreased with older age [(adjusted Odds Ratio (aOR), 0.92; 95% CI, 0.89– 0.93,p= 0.001], living in high poverty neighborhood (aOR, 0.52; 95% CI, 0.44 – 0.66,p< 0.0001), having Medicaid (aOR, 0.58; 95% CI, 0.44 – 0.73,p= 0.02), being uninsured (aOR, 0.49; 95% CI, 0.31 – 0.64,p= 0.01), and having comorbidities (CCI score 1: aOR, 0.48; 95% CI, 0.34 – 0.71,p= 0.003; CCI score ≥ 2: aOR, 0.32; 95% CI, 0.16 – 0.56,p< 0.0001).Conclusions and relevanceThis cohort study identified sociodemographic and socioeconomic disparities in access to immunotherapy in Texas, highlighting the need for policies such as Medicaid expansion that would increase equitable access to this innovative therapy.Supplementary InformationThe online version contains supplementary material available at 10.1186/s12885-023-11142-4.