BackgroundArtificial intelligence (AI) is a broad spectrum of computer-executed operations that mimics the human intellect. It is expected to improve healthcare practice in general and radiology in particular by enhancing image acquisition, image analysis, and processing speed. Despite the rapid development of AI systems, successful application in radiology requires analysis of social factors such as the public’s perspectives toward the technology.ObjectivesThe current study aims to investigate the general population’s perspectives on AI implementation in radiology in the Western region of Saudi Arabia.MethodsA cross-sectional study was conducted from November 2022 and July 2023 utilizing a self-administrative online survey distributed via social media platforms. A convenience sampling technique was used to recruit the study participants. After obtaining Institutional Review Board approval, data were collected from citizens and residents of the western region of Saudi Arabia aged 18 years or older.ResultsA total of 1,024 participants were included in the present study, with the mean age of respondents being 29.6 ± 11.3. Of them, 49.9% (511) were men, and 50.1% (513) were women. The comprehensive mean score of the first four domains among our participants was 3.93 out of 5.00. Higher mean scores suggest being more negative regarding AI in radiology, except for the fifth domain. Respondents had less trust in AI utilization in radiology, as evidenced by their overall distrust and accountability domain mean score of 3.52 out of 5. The majority of respondents agreed that it is essential to understand every step of the diagnostic process, and the mean score for the procedural knowledge domain was 4.34 out of 5. The mean score for the personal interaction domain was 4.31 out of 5, indicating that the participants agreed on the value of direct communication between the patient and the radiologist for discussing test results and asking questions. Our data show that people think AI is more effective than human doctors in making accurate diagnoses and decreasing patient wait times, with an overall mean score of the efficiency domain of 3.56 out of 5. Finally, the fifth domain, “being informed,” had a mean score of 3.91 out of 5.ConclusionThe application of AI in radiologic assessment and interpretation is generally viewed negatively. Even though people think AI is more efficient and accurate at diagnosing than humans, they still think that computers will never be able to match a specialist doctor’s years of training.