A series of experiments have been carried out on the flooding of microfluidic chips simulating a homogeneous porous structure with various displacement fluids. Water and polyacrylamide polymer solutions were used as displacement fluids. Three different polyacrylamides with different properties are considered. The results of a microfluidic study of polymer flooding showed that the displacement efficiency increases significantly with increasing polymer concentration. Thus, when using a 0.1% polymer solution of polyacrylamide grade 2540, a 23% increase in the oil displacement efficiency was obtained compared to water. The study of the effect of various polymers on the efficiency of oil displacement showed that the maximum efficiency of oil displacement, other things being equal, can be achieved using polyacrylamide grade 2540, which has the highest charge density among those considered. Thus, when using polymer 2515 with a charge density of 10%, the oil displacement efficiency increased by 12.5% compared to water, while when using polymer 2540 with a charge density of 30%, the oil displacement efficiency increased by 23.6%.