AbstractAimsOur study focused on exploring the feasible prognostic laboratory parameters of HCC and establishing a score model to estimate individualized overall survival (OS) in HCC after resection.MethodsFour hundred and sixty‐one patients with HCC who underwent hepatectomy between January 2010 and December 2017 was enrolled in this investigation. Cox proportional hazards model was conducted to analyze the prognostic value of laboratory parameters. The score model construction was based on the forest plot results. Overall survival was evaluated by Kaplan‐Meier method and the log‐rank test. The novel score model was validated in an external validation cohort from a different medical institution.ResultsWe identified that alpha fetoprotein (AFP), total bilirubin (TB), fibrinogen (FIB), albumin (ALB), and lymphocyte (LY) were independent prognostic factors. High AFP, TB, FIB (HR > 1,p< 0.05), and low ALB, LY (HR < 1,p< 0.05) were associated with the survival of HCC. The novel score model of OS based on these five independent prognostic factors achieved high C‐index of 0.773 (95% confidence interval [CI]: 0.738–0.808), which was significantly higher than those of the single five independent factors (0.572–0.738). The score model was validated in the external cohort whose C‐index was 0.7268 (95% CI: 0.6744–0.7792).ConclusionThe novel score model we established was an easy‐to‐use tool which could enable individualized estimation of OS in patients with HCC who underwent curative hepatectomy.