Spatial variation of indoor and outdoor PM2.5within three states for a five-year period is studied using regulatory and low-cost PurpleAir monitors. Most of these data were collected in an earlier study (Wallace et al., 2022Indoor Air32:13105) investigating the relative contribution of indoor-generated and outdoor-infiltrated particles to indoor exposures. About 260 regulatory monitors and ~10,000 outdoor and ~4000 indoor PurpleAir monitors are included. Daily mean PM2.5concentrations, correlations, and coefficients of divergence (COD) are calculated for pairs of monitors at distances ranging from 0 (collocated) to 200 km. We use a transparent and reproducible open algorithm that avoids the use of the proprietary algorithms provided by the manufacturer of the sensors in PurpleAir PA-I and PA-II monitors. The algorithm is available on the PurpleAir API website under the name “PM2.5_alt”. This algorithm is validated using several hundred pairs of regulatory and PurpleAir monitors separated by up to 0.5 km. The PM2.5spatial variation outdoors is homogeneous with high correlations to at least 10 km, as shown by the COD index under 0.2. There is also a steady improvement in outdoor PM2.5concentrations with increasing distance from the regulatory monitors. The spatial variation of indoor PM2.5is not homogeneous even at distances < 100 m. There is good agreement between PurpleAir outdoor monitors located <100 m apart and collocated Federal Equivalent Methods (FEM).