Key PointsQuestionHow accurate are general pediatricians at assessing children for autism spectrum disorder (ASD) compared with a multidisciplinary team?FindingsThis diagnostic study enrolled 17 general pediatricians and 106 children with possible ASD who were referred to them. When the pediatrician thought ASD was present, the team agreed 89% of the time; when the pediatrician did not think ASD was present, the team agreed only 60% of the time.MeaningThe concordance between pediatrician diagnosis of ASD and that of an expert team was high, but when ruling out ASD, the concordance was lower; additionally, children with co-occurring delays are potential candidates for community assessment.