High-pressure injection injuries present to trauma centers a few times each year, typically involving the patient's non-dominant hand.1–6Symptoms may include progressive pain, numbness, swelling of the affected area, and decreased range of motion.2,6–8These injuries are important to recognize because the initial injury can involve damage to ligaments, tendons, and neurovascular structures.1–5Pressure increases, from the injected material and subsequent tissue swelling, can result in vascular injury and compartment syndrome.1,2,5Antibiotics and prompt surgical evaluation are vital because high-pressure injection injuries are considered a surgical emergency.1,2,7–9TopicsHigh-pressure injection injuries, hand injuries, orthopedics