Even thoughHelicobacter pylori(H. pylori) is a serious pathogen, its origin is unknown. Poultry (chicken, turkey, quail, goose, and ostrich) is consumed as a regular protein source by many people across the world; therefore, sanitary ways of delivering poultry for food are important for global health. As a result, the distribution of the virulence genescagA,vacA,babA2,oipA, andiceAinH. pyloriisolates in poultry meat, as well as their antibacterial resistance, was investigated. A Wilkins Chalgren anaerobic bacterial medium was used to cultivate 320 samples of raw poultry meat. Disk diffusion and multiplex-PCR were used to investigate both antimicrobial resistance and genotyping patterns.H. pyloriwas found in 20 of 320 (6.25 %) raw chicken meat samples. The highest incidence ofH. pyloriwas found in chicken raw meat (15%), whereas no isolate was recovered from goose or quail raw meat (0.00%). Resistance to ampicillin (85%), tetracycline (85%), and amoxicillin (75%) were the most commonly detected in the testedH. pyloriisolates. The percentage ofH. pyloriisolates with a multiple antibiotic resistance (MAR) index value of more than 0.2 was 17/20 (85%). The most prevalent genotypes detected wereVacA(75%),m1a(75%),s2(70%) andm2(65%), andcagA(60%). The most typically detected genotype patterns weres1am1a(45 %),s2m1a(45 %), ands2 m2(30%).babA2,oipA+, andoipA- genotypes were found in 40%, 30%, and 30% of the population, respectively. In summary, fresh poultry meat was polluted byH. pylori, with thebabA2,vacA, andcagAgenotypes being more prevalent. The simultaneous occurrence ofvacA,cagA,iceA,oipA, andbabA2genotypes in antibiotic-resistantH. pyloribacteria raises a serious public health concern regarding the consumption of raw poultry. Future research should evaluate antimicrobial resistance amongH. pyloriisolates in Iran.