Since the seminal work of Heider and Simmel, and Michotte’s research, many studies have shown that, under appropriate conditions, displays of simple geometric shapes elicit rich and vivid impressions of animacy and intentionality. The main purpose of this review is to emphasize the close relationship between kinematics and perceived animacy by showing which specific motion cues and spatiotemporal patterns automatically trigger visual perceptions of animacy and intentionality. The animacy phenomenon has been demonstrated to be rather fast, automatic, irresistible, and highly stimulus-driven. Moreover, there is growing evidence that animacy attributions, although usually associated with higher-level cognition and long-term memory, may reflect highly specialized visual processes that have evolved to support adaptive behaviors critical for survival. The hypothesis of a life-detector hardwired in the perceptual system is also supported by recent studies in early development and animal cognition, as well as by the issue of the “irresistibility” criterion, i.e., the persistence of animacy perception in adulthood even in the face of conflicting background knowledge. Finally, further support for the hypothesis that animacy is processed in the earliest stages of vision comes from recent experimental evidence on the interaction of animacy with other visual processes, such as visuomotor performance, visual memory, and speed estimation. Summarizing, the ability to detect animacy in all its nuances may be related to the visual system’s sensitivity to those changes in kinematics – considered as a multifactorial relational system - that are associated with the presence of living beings, as opposed to the natural, inert behavior of physically constrained, form-invariant objects, or even mutually independent moving agents. This broad predisposition would allow the observer not only to identify the presence of animates and to distinguish them from inanimate, but also to quickly grasp their psychological, emotional, and social characteristics.