Due to more advanced features of the picture fuzzy soft set and valuable characteristics of aggregation operators, in this article, we present the notion of picture fuzzy soft Bonferroni mean aggregation operators and weighted picture fuzzy soft Bonferroni mean aggregation operators. Moreover, some basic properties of these introduced aggregation operators have been given. As cancer is one of the most rapidly increasing diseases globally. But due to different kinds of cancer diseases, it is very difficult to say which type of cancer disease is increasing rapidly. So to reduce this difficulty in the medical field, we have applied our work to medical diagnosis problems to ensure that fuzzy ideas can also help in the medical field. Also, an algorithm along with a descriptive example is established that conforms to the authenticity of initiated work. Furthermore, a comparative analysis of the introduced work has been given to show how this work is more efficient and dominant than other existing theories.