The coronavirus (Covid-19) pandemic has affected not only populations around the world but also the environment and natural resources. Lockdowns and restricted lifestyles have had wide-ranging impacts on the environment (e.g., air quality in cities). Although hygiene and disinfection procedures and precautions are effective ways to protect people from Covid-19, they have significant consequences for water usage and resources especially given the increasing impacts of climate change on rainfall patterns, water use and resources. Climate change and public health issues may compound one another, and so we used a drivers, pressures, state, impact, response framework (not previously used to examine the actual and potential impacts of Covid-19 and climate change on water consumption and resources) to scope the main factors that may interact to affect water use and resources (in the form of reservoirs) using evidence from Istanbul, Türkiye, with some discussion of the comparative situation elsewhere. We modified initial views on the framework to account for the regional, city and community level experiences. We note that water consumption in Istanbul has been increasing over the last two decades (except in times of very low rainfall/drought); that there were increases in water consumption in the early stages of the Covid-19 pandemic; and, despite some increase in rainfall, water levels in reservoirs appeared to decrease during lockdowns (for a range of reasons). Through a new simple way of visualising the data, we also noted that a low resource capacity might be recurring every 6 or 7 years in Istanbul (a similar finding to Thames Reservoir in London). We made no attempt in this paper to quantify the relative contribution that climate change, population growth, etc., are making to water consumption and reservoir levels as we focused on looking at those social, environmental and economic factors that appear to play a role in potential water stress and on developing a drivers, pressures, state, impact, response framework for policy and adaptive management options for Istanbul and other large complex conurbations. If there are periodic water resource issues and temperatures rise as expected in climate projections with an accompanying increase in the duration of hot spells, the subsequent additional stress on water systems might make managing future public health emergencies, such as a pandemic, even more difficult.