AbstractPurposeTo evaluate the treatment outcome of surgical punctal occlusion with combined canaliculi ablation and punctal suturing in patients with severe dry eye.MethodsEleven eyes of seven patients were diagnosed with severe dry eye with decreased lacrimal secretion and were refractory to treatment with various eye drops and/or had repeatedly experienced loss of punctal plugs, and continued to experience subjective symptoms received surgical punctal occlusion. In 20 puncta, lacrimal canaliculi ablation was performed along the entire length of the lacrimal canaliculus where a diathermy needle could be inserted. After resection of the annulus fibrosus in the peri-punctal area, tight cross-stitch suturing of the puncta was performed with 8-0 absorbent thread. Visual acuity, corneal staining score according to the area (A) and density (D) classification, and Schirmer tear test (STT); tear break up time (tBUT); and subjective symptoms assessed by the University of North Carolina (UNC) and Dry Eye Management Scale were compared before and one year after surgery.ResultsRecanalization occurred in 1/20 puncta (5.0% at month 5) in 1/11 eyes. Student'st-test showed significant improvement at one year compared with preoperative values for LogMAR value (P= 0.019), corneal staining score A (P= 0.00003) and D (P= 0.0003), STT (P= 0.004), and subjective symptoms (P= 0.015). No change was shown in tBUT and no serious adverse event occurred.ConclusionThis improved, minimally invasive surgical procedure has a low recanalization rate and achieves both objective and subjective improvements at one year.