Trichodermais mainly used to control soil-borne diseases as well as some leaf and panicle diseases of various plants.Trichodermacan not only prevent diseases but also promotes plant growth, improves nutrient utilization efficiency, enhances plant resistance, and improves agrochemical pollution environment.Trichodermaspp. also behaves as a safe, low-cost, effective, eco-friendly biocontrol agent for different crop species. In this study, we introduced the biological control mechanism ofTrichodermain plant fungal and nematode disease, including competition, antibiosis, antagonism, and mycoparasitism, as well as the mechanism of promoting plant growth and inducing plant systemic resistance betweenTrichodermaand plants, and expounded on the application and control effects ofTrichodermain the control of various plant fungal and nematode diseases. From an applicative point of view, establishing a diversified application technology forTrichodermais an important development direction for its role in the sustainable development of agriculture.