Simple SummaryThe incidence of endometrial cancer is especially high among women over 70 years old. Problems can be encountered if an interest in minimally invasive surgery has been expressed, as there is a lack of evidence regarding the benefits of Enhanced Recovery After Surgery (ERAS) programs with respect to endometrial cancer management. The aim of this observational prospective study was to assess ERAS programs’ impact on length of stay, early discharge, and post-operative morbidity in the general population and among patients over 70 years old. We found a significantly shorter length of stay and a higher rate of early discharge with similar rates of post-operative complications in the group associated with the ERAS pathway. These results were even more significant among the elderly.AbstractEndometrial cancer is the fifth most common cancer among French women and occurs most frequently in the over-70-year-old population. Recent years have seen a significant shift towards minimally invasive surgery and Enhanced Recovery After Surgery (ERAS) protocols in endometrial cancer management. However, the impact of ERAS on endometrial cancer has not been well-established. We conducted a prospective observational study in a comprehensive cancer center, comparing the outcomes between endometrial cancer patients who received care in an ERAS pathway (261) and those who did not (166) between 2006 and 2020. We performed univariate and multivariate analysis. Our primary objective was to evaluate the impact of ERAS on length of hospital stay (LOS), with the secondary objectives being the determination of the rates of early discharge, post-operative morbidity, and rehospitalization. We found that patients in the ERAS group had a significantly shorter length of stay, with an average of 3.18 days compared to 4.87 days for the non-ERAS group (estimated decrease −1.69,p< 0.0001). This effect was particularly pronounced among patients over 70 years old (estimated decrease −2.06,p< 0.0001). The patients in the ERAS group also had a higher chance of early discharge (47.5% vs. 14.5% in the non-ERAS group,p< 0.0001), for which there was not a significant increase in post-operative complications. Our study suggests that ERAS protocols are beneficial for the management of endometrial cancer, particularly for older patients, and could lead to the development of ambulatory pathways.