Reading is typically guided by a task or goal (e.g., studying for a test, writing a paper). A reader’s task awareness arises from their mental representation of the task and plays an important role in guiding reading processes, ultimately influencing comprehension outcomes and task success. As such, a better understanding of how task awareness arises and how it affects comprehension is needed. The present study tested the Task Awareness Mediation Hypothesis. This hypothesis assumes that the strategies that support reading comprehension (e.g., paraphrasing, bridging, and elaborative strategies) also support a reader’s task awareness while engaged in a literacy task. Further, it assumes that the reader’s level of task awareness partially mediates the relationship between these comprehension strategies and a comprehension outcome. At two different time points in a semester, college students completed an assessment of their propensity to engage in comprehension strategies and a complex academic literacy task that provided a measure of comprehension outcomes and an assessment of task awareness. Indirect effects analyses provided evidence for the Task Awareness Mediation Hypothesis showing that the propensity to engage in paraphrasing and elaboration was positively predictive of task awareness, and that task awareness mediated the relationships between these comprehension strategies and performance on the complex academic literacy task. These results indicate that task awareness has complex relationships with comprehension strategies and performance on academic literacy tasks and warrants further consideration as a possible malleable factor to improve student success.