The aim of this study is to assess Portuguese celiac patients’ quality of life (QoL) perception. A cross-sectional study was performed with a non-probability convenience sample of Portuguese celiac patients using an online self-administered celiac disease quality of life questionnaire (CDQ), previously validated for the Portuguese population. The final sample comprised 234 celiac patients, which included the following: primarily women (69.2%); aged between 18 and 49 years old (56.4%); with a partner (60.6%); with a high educational level (58.9%—graduated or post-graduated); following a gluten-free diet (GFD) (55.1%); and not using antidepressants (93.1%). The Portuguese CDQ presented good reliability and responsiveness in this sample of Portuguese celiac patients. In general, the CDQ in Portugal was affected by age at diagnosis (p= 0.017), educational level (p= 0.005), and compliance with GFD (p= 0.034). The emotion domain was affected only by using antidepressants (p= 0.036). The social domain was affected by gender (females had lower rates,p= 0.016), age at diagnosis (p= 0.009), educational level (p= 0.000), and compliance with a GFD (p= 0.002). The worries domain did not differ according to socioeconomic data. The symptoms domain was affected by compliance with GFD (p= 0.000), age at diagnosis (p= 0.000), and educational level (p= 0.014). Data on celiac QoL is essential to support the formulation and implementation of strategies to minimize the issues suffered by celiac patients, lowering their physical, emotional, and social burden. Additionally, data on Portuguese celiac disease patients using the CDQ will allow future comparative research among celiac populations from different countries.