PurposeTo report on the accuracy of automated delineation, treatment plan quality, and duration of an in-silico “scan-(pre)plan-treat” (SPT) workflow for vertebral bone metastases using a 1 × 8 Gy regimen.Method and MaterialsThe cloud-based emulator system of the Ethos therapy system was used to adapt an organ-at-risk-sparing preplan created on the diagnostic CT to the anatomy-of-the-day using the cone beam CT made before treatment.ResultsSPT using the Ethos emulator system resulted in relatively good coverage of the PTV and acceptable dose to the OAR. Delivery time and plan homogeneity was the best for 7-field IMRT plan template.ConclusionsA SPT workflow formula results in a highly conformal treatment delivery while maintaining an acceptable timeframe for the patient on the treatment couch.