Based upon a mixed-methods follow-up exploratory model, we examined the link between trust and coping during the early outbreak of the COVID-19 pandemic at the society level. Qualitative data were collected from the supportive messages written by 10,072 community adults across 35 societies. Trust and coping were used as the two pre-defined themes in the conceptual content analysis. Five subthemes emerged from the theme trust, depicting five distinct trusted targets: God, a larger us, country/government, science/healthcare, and the affected. Six subthemes emerged from the theme coping, depicting six distinct coping strategies: interpersonal/social coping, religious/spiritual coping, acceptance, blame, wishful thinking, and strength-based coping. A follow-up quantitative investigation also showed that four society-level factors (viz., individualism, cultural tightness, globalization, and severity of pandemic) had differential effects on people’s trusted targets and ways of coping with the pandemic. Our study made both methodological and practical contributions to cross-cultural research on COVID-19 by using a mixed-methods approach in a multinational study and demonstrating the importance of making meaningful virtual connection during a time of physical distancing.