Simple SummaryThe red palm weevil poses a significant threat to palm species, resulting in substantial economic losses. While multiple methods have been developed to control its infestations, there is an urgent need for eco-friendly insecticides that selectively target its critical systems or pathways. One such target is its digestive system, which is essential for its survival. This review highlights the potential of using the digestive system of the red palm weevil to manage its infestations. Proteomic and transcriptomic data analyses on the weevils have provided a better understanding of the protein and gene compositions in its digestive system. With technological advancements, a more comprehensive approach can be taken to explore the opportunities in manipulating the data on the digestive system of red palm weevil, leading to improved management methods.AbstractRhynchophorus ferrugineus,commonly known as red palm weevil (RPW), is a high-risk insect pest that has become a threat to many important palm species. There are several dominant factors that lead to the successful infestation of RPW, including its stealthy lifestyle, highly chitinized mouthpart, and high fecundity rate. Due to that, millions of dollars of losses have been suffered by many countries invaded by RPW. Several methods have been designed to control its invasion, including the usage of insecticides, but many cause resistance and environmental pollution. Therefore, an environmentally friendly insecticide that targets specific systems or pathways in RPW is urgently needed. One of the potential targets is the digestive system of RPW, as it is the major interface between the insect and its plant host. The related knowledge of RPW’s digestive system, such as the anatomy, microflora, transcriptomic analysis, and proteomic analysis, is important to understand its effects on RPW’s survival. Several data from different omics regarding the digestive systems of RPW have been published in separate reports. Some of the potential targets have been reported to be inhibited by certain potential insecticides, while other targets have not yet been tested with any inhibitors. Hence, this review may lead to a better understanding on managing infestations of RPW using the system biology approach for its digestive system.