Existing approaches to robotic manipulation often rely on external mechanical devices, such as hydraulic and pneumatic devices or grippers. Both types of devices can be adapted to microrobots only with difficulties and for nanorobots not all. Here, we present a fundamentally different approach that is based on tuning the acting surface forces themselves rather than applying external forces by grippers. Tuning of forces is achieved by the electrochemical control of an electrode’s diffuse layer. Such electrochemical grippers can be integrated directly into an atomic force microscope, allowing for ‘pick and place’ procedures typically used in macroscopic robotics. Due to the low potentials involved, small autonomous robots could as well be equipped with these electrochemical grippers that will be particularly useful in soft robotics as well as nanorobotics. Moreover, these grippers have no moving parts and can be incorporated in new concepts for actuators. The concept can easily be scaled down and applied to a wide range of objects, such as colloids, proteins, and macromolecules.