Infective endocarditis refers to infection of one or more valves of the heart, withAchromobacter xylosoxidans(A. xylosoxidans) being a rare cause. So far, 24 cases ofA. xylosoxidansendocarditis were reported, with only one case describing tricuspid valvular involvement. Despite the rarity ofA. xylosoxidansendocarditis, it is important for clinicians to be aware of atypical presentation and the high mortality associated with it. We present an autopsy-proven case of tricuspid valve endocarditis in the setting ofA. xylosoxidansbacteremia in a 43-year-old female.