IntroductionEvidence suggests that oral potentially malignant disorders (OPMDs) are linked to increased possibilities of malignant transformation, creating a challenging situation. If oral cancer is detected early, the prognosis is better. The purpose of this study was to compare the serum levels of urea, uric acid (UA), and creatine kinase in patients with provisionally diagnosed and histopathologically confirmed cases of potentially malignant disorders and oral cancer to those of age- and sex-matched healthy controls.Materials and methodsEighty patients over the age of 18 with a clinical diagnosis of oral potentially malignant disorder (OPMD) or oral cancer and verified histopathology were included in the research. Using the kinetic methodology, the enzymatic colorimetric method, and the UV-kinetic approach, respectively, the serum concentrations of urea, uric acid, and creatine kinase were quantified in vitro following the venipuncture of 2 mL of venous blood. The Statistical Package for the Social Sciences (SPSS) version 20 (IBM SPSS Statistics, Armonk, NY, USA) was used for the statistical analysis.ResultsComparing OPMD and oral cancer patients to healthy controls, serum urea levels were found to be greater, uric acid levels to be lower, and creatine kinase levels to be higher.ConclusionPrognostic markers for OPMDs and oral cancer may include urea, uric acid, and creatine kinase. However, this may be accomplished by large-scale prospective research.