Key PointsQuestionHow have emergency medicine physicians’ social media content and language changed during COVID-19, and can they provide insight into physician well-being?FindingsIn this cross-sectional study of 471 academic emergency physicians and resident physicians, key differences in the social media content of before and during the pandemic were identified, including language associated with higher levels of anxiety, anger, and depression during the pandemic.MeaningThese findings suggest that social media content can provide insight into emergency medicine physicians’ mental well-being and may reveal signals related to burnout by identifying higher levels of mental health strain and key changes in thematic content.