This work aimed to obtain poly(glycerol citraconate)
(PGCitrn)
for biomedical applications, analyze the obtained polyester by spectroscopic
methods, and optimize its preparation. Polycondensation reactions
of glycerol and citraconic anhydride were carried out. It was provided
that the results in the reaction are oligomers of poly(glycerol citraconate).
Optimization studies were carried out based on the Box–Behnken
design. The input variables in this plan were the ratio of functional
groups, temperature, and time and occurrence in coded form: −1,
0, or 1. Three output variables were optimized: the degree of esterification,
the percentage ofZ-mers, and the degree of carboxyl
group conversion; they were determined by titration and spectroscopic
methods. The optimization criterion was to maximize the values of
output variables. A mathematical model and an equation describing
it were determined for each output variable. The models predicted
the experimental results well. An experiment was conducted under determined
optimal conditions. The experimental results were very close to the
calculated values. Poly(glycerol citraconate) oligomers with an esterification
degree of 55.2%, aZ-mer content of 79.0%, and a
degree of rearrangement of carboxyl groups of 88.6% were obtained.
The obtained PGCitrn can serve as a component of an injectable implant.
The obtained material can be used to produce nonwoven fabrics (with
the addition of PLLA, for example), which can be subjected to a cytotoxicity
test which can then serve as a dressing material.