Key clinical messageAcute anterior uveitis and optic disk edema could be a manifestation of COVID‐19 infection, and healthcare providers should be aware of this possible consequence for in‐time diagnosis and treatment.AbstractSince the beginning of the coronavirus disease‐2019 (COVID‐19) pandemic, a wide range of clinical manifestations have been associated with this novel infection. The objective of this study was to show that acute anterior uveitis and optic disk edema could be possible manifestations of COVID‐19 infection. The patient was a nine‐year‐old girl presenting with prolonged fever, myalgia, cough, diarrhea, and skin rashes. She also reported blurred vision, Photophobia, and eye redness. PCR test for COVID‐19 returned positive. Imaging investigations showed pleural and pericardial effusion, mediastinal lymphadenopathy, and heart valve regurgitation. She was diagnosed with MIS‐C and treated with methylprednisolone and IVIG. Bilateral acute anterior uveitis and optic disk edema was detected by slit lamp and fundus examination. She was successfully treated and follow‐up ophthalmologic examinations showed improvement.