Water recovery from aqueous effluents in the mining and metals processing industry poses a unique challenge due to the high concentration of dissolved salts typically requiring energy intensive methods of treatment. Forward osmosis (FO) is a lower energy technology which employs a draw solution to osmotically extract water through a semi-permeable membrane further concentrating any feed. Successful FO operation relies on using a draw solution of higher osmotic pressure than the feed to extract water while minimizing concentration polarization to maximize the water flux. Previous studies employing FO on industrial feed samples commonly used concentration instead of osmotic pressures for feed and draw characterization; this led to misleading conclusions on the impact of design variables on water flux performance. By employing a factorial design of experiments methodology, this study examined the independent and interactive effects on water flux by: osmotic pressure gradient, crossflow velocity, draw salt type, and membrane orientation. With a commercial FO membrane, this work tested a solvent extraction raffinate and a mine water effluent sample to demonstrate application significance. By optimizing with osmotic gradient independent variables, water flux can be improved by over 30% without increasing energy costs or compromising the 95–99% salt rejection of the membrane.