This work proposes the development of a polymer film made up of affordable components for its use as a healthcare material. Chitosan, itaconic acid, andRandia capitatafruit extract (Mexican variation) are the unique ingredients of this biomaterial prospect. Chitosan (from crustacean chitin) is crosslinked with itaconic acid, and in situ addedR. capitatafruit extract in a one-pot reaction carried out in water as the sole solvent. Structurally, the film formed is an ionically crosslinked composite characterized by IR spectroscopy and thermal analysis (DSC and TGA); cell viability was also performed in vitro using fibroblasts BALB/3T3. Dry and swollen films were analyzed to determine affinity and stability in water. This chitosan-based hydrogel is designed as a wound dressing due to the combined properties of the chitosan withR. capitatafruit extract, which has potential as bioactive material due to its properties in epithelial regeneration.