Ionospheric irregularities are plasma density variations that occur at various altitudes and latitudes and whose size ranges from a few meters to a few hundred kilometers. They can have a negative impact on the Global Navigation Satellite Systems (GNSS), on their positioning accuracy and even cause a signal loss of lock (LoL), a phenomenon for which GNSS receivers can no longer track the satellites’ signal. Nowadays, the study of plasma density irregularities is important because many of the crucial infrastructures of our society rely on the efficient operation of these positioning systems. It was recently discovered that, of all possible ionospheric plasma density fluctuations, those in a turbulent state and characterized by extremely high values of the Rate Of change of the electron Density Index appear to be associated with the occurrence of LoL events. The spatial distributions of this class of fluctuations at mid and high latitudes are reconstructed for the first time using data collected on Swarm satellites between July 15th, 2014 and December 31st, 2021, emphasizing their dependence on solar activity, geomagnetic conditions, and season. The results unequivocally show that the identified class of plasma fluctuations exhibits spatio-temporal behaviours similar to those of LoL events.