Key PointsQuestionIs historical redlining associated with cardiovascular disease outcomes in US veterans?FindingsIn this cohort study, 79 997 veterans residing in redlined areas (Home Owners’ Loan Corporation–established maps of US neighborhoods considered high risk for mortgage) had a higher risk of major adverse cardiovascular events and all-cause mortality compared with individuals in areas considered not at high risk. This association was also noted independent of traditional cardiovascular risk factors.MeaningThe findings of this cohort study suggest that redlining is still adversely associated with cardiovascular events throughout the US.