Highlights•The use of e-cigarettes in combination with other tobacco products among youth is not uncommon.•Sole e-cigarette, dual and poly users of tobacco products had a higher prevalence of substance misuse than nonusers.•Dual and poly users were more likely to engage in substance misuse than sole e-cigarette users.•These findings highlight the clustering of tobacco use with substance misuse and emphasize the need for comprehensive efforts to address youth high-risk behaviors.