The fatigue damage of a local joint is the key factor accounting for the structural failure of a jacket-type offshore wind turbine. Meanwhile, the structure experiences a complex multiaxial stress state under wind and wave random loading. This paper aims to develop a multi-scale modeling method for a jacket-type offshore wind turbine, in which local joints of the jacket are modeled in a detail by using solid elements, and other components are modeled via the common beam element. Considering the multiaxial stress state of the local joint, multi-axial fatigue damage analysis based on the multiaxialS–Ncurve is performed using equivalent Mises and Lemaitre methods. The uniaxial fatigue damage data of the jacket model calculated using the multi-scale finite element model are compared with those of the conventional beam model. The results show that the tubular joint of jacket leg and brace connections can be modeled using the multi-scale method, since the uniaxial fatigue damage degree can reach a 15% difference. The comparison of uniaxial and multiaxial fatigue results obtained using the multi-scale finite element model shows that the difference can be about 15% larger. It is suggested that the multi-scale finite element model should be used for better accuracy in the multiaxial fatigue analysis of the jacket-type offshore wind turbine under wind and wave random loading.