In this research, Fe3O4@HZSM-5 magnetic nanocomposite was synthesized via a coprecipitation method for metronidazole (MNZ) degradation from aqueous solutions under ultrasonic irradiation which showed superb sonocatalytic activity. The synthesized magnetite nanocomposite was characterized by using field-emission scanning electron microscope-energy dispersive X-ray Spectroscopy, (FESEM-EDS), Line Scan, Dot Mapping, X-ray diffraction (XRD), vibrating sample magnetometer (VSM), and Brunauer-Emmett-Teller (BET). To investigate the sonocatalytic activity of the Fe3O4@HZSM-5 magnetite nanocomposite, the sonocatalytic removal conditions were optimized by evaluating the influences of operating parameters like the dosage of catalyst, reaction time, pH, the concentration of H2O2, MNZ concentration, and pH on the MNZ removal. The MNZ maximum removal efficiency and TOC at reaction time 40 min, catalyst dose 0.4 g/L, H2O2concentration 1 mM, MNZ initial concentration 25 mg/L, and pH 7 were achieved at 98% and 81%, respectively. Additionally, the MNZ removal efficiency in the real wastewater sample under optimal conditions was obtained at 83%. The achieved results showed that using Langmuir-Hinshelwood kinetic model KL-H= 0.40 L mg−1, KC= 1.38 mg/L min) can describe the kinetic removal of the process. The radical scavenger tests indicated that the major reactive oxygen species were formed by hydroxyl radicals in the Sono-Fenton-like process. Evaluation of the nanocomposite reusability showed an 85% reduction in the MNZ removal efficiency after seven cycles. Based on the results, it can be concluded that Fe3O4@HZSM-5 were synthesized as magnetic heterogeneous nano-catalysts to effectively degrade MNZ, and the observed stability and recyclability demonstrated that Fe3O4@HZSM-5 was promising for the treatment of wastewater contaminated with antibiotics.