Simple SummaryGlobally, rivers are continuously being polluted because of anthropogenic discharge, especially in Asian countries experiencing rapid urban, industrial and agricultural developments. Exceedingly high concentrations of nutrients and toxic metals have been detected in most Asian rivers, which has led to major environmental and human health concerns that demand the detoxification of polluted river water. This study investigated and compared the efficacy of microalgae (Chlorella vulgaris) and cyanobacteria (Anabaena variabilis) as a low-cost and eco-friendly approach to remediate polluted river water. The results revealed that both microalgae and cyanobacteria have the potential to reduce the pollutant load from the raw river water, but the removal efficiency is species dependent. The studied microalgal and cyanobacterial species are excellent candidates for polluted water and/or wastewater treatment as well as producers of energy-rich biomass that can be further processed to produce biofuel, biodiesel, and other bio-hydrocarbons.AbstractThis study investigated the phycoremediation abilities ofChlorella vulgaris(microalga) andAnabaena variabilis(cyanobacterium) for the detoxification of polluted river water. Lab-scale phycoremediation experiments were conducted for 20 days at 30 °C using the microalgal and cyanobacterial strains and water samples collected from the Dhaleswari river in Bangladesh. The physicochemical properties such as electrical conductivity (EC), total dissolved solids (TDS), biological oxygen demand (BOD), hardness ions, and heavy metals of the collected water samples indicated that the river water is highly polluted. The results of the phycoremediation experiments demonstrated that both microalgal and cyanobacterial species significantly reduced the pollutant load and heavy metal concentrations of the river water. The pH of the river water was significantly raised from 6.97 to 8.07 and 8.28 byC. vulgarisandA. variabilis, respectively.A. variabilisdemonstrated higher efficacy thanC. vulgarisin reducing the EC, TDS, and BOD of the polluted river water and was more effective at reducing the pollutant load of SO42−and Zn. In regard to hardness ions and heavy metal detoxification,C. vulgarisperformed better at removing Ca2+, Mg2+, Cr, and Mn. These findings indicate that both microalgae and cyanobacteria have great potential to remove various pollutants, especially heavy metals, from the polluted river water as part of a low-cost, easily controllable, environmentally friendly remediation strategy. Nevertheless, the composition of polluted water should be assessed prior to the designing of microalgae- or cyanobacteria-based remediation technology, since the pollutant removal efficiency is found to be species dependent.