Bone defects are severe conditions caused by various etiologies, including trauma, tumor resection, or chronic osteomyelitis. Different surgical interventions can be utilized to manage such cases, including autologous graft or allograft implantation, distraction osteogenesis, acute shortening, amputation, or the induced membrane technique. Herein, the case of a 39-year-old woman with complex bilateral distal femoral fractures with intra-articular extension is presented. The fractures were accompanied by a significant metaphyseal bone defect, which was managed successfully using the induced membrane Masquelet technique. The patient fully healed despite residual knee joint contractures that did not inhibit her mobility. In conclusion, the Masquelet technique successfully manages complex bone defects and restores functionality even in bilateral simultaneous open bone defects.