Salinity is a major abiotic stress that harms rice growth and productivity. Low phosphate roots (LPRs) play a central role in Pi deficiency-mediated inhibition of primary root growth and have ferroxidase activity. However, the function of LPRs in salt stress response and tolerance in plants remains largely unknown. Here, we reported that theOsLPR5was induced by NaCl stress and positively regulates the tolerance to salt stress in rice. Under NaCl stress, overexpression ofOsLPR5led to increased ferroxidase activity, more green leaves, higher levels of chlorophyll and lower MDA contents compared with the WT. In addition, OsLPR5 could promote the accumulation of cell osmotic adjustment substances and promote ROS-scavenging enzyme activities. Conversely, the mutantlpr5had a lower ferroxidase activity and suffered severe damage under salt stress. Moreover, knock out ofOsLPR5caused excessive Na+levels and Na+/K+ratios. Taken together, our results exemplify a new molecular link between ferroxidase and salt stress tolerance in rice.