In this study, an analysis was performed to investigate the thermal and mass transport of radiative flow of a third-grade nanofluid with magnetohydrodynamic. The analysis concerns two-dimensional flow around an infinite disk. Heat transport is studied via heat generation/absorption, thermal radiation and Joule heating. Chemical reaction with activation energy is also considered. The nanofluid characteristics, including Brownian motion and thermophoretic diffusion, are explored via the Buongiorno model. Entropy analysis is also conducted. Moreover, the surface tension is assumed to be a linear function of concentration and temperature. Through adequate dimensionless variables, governed PDEs are non-dimensionlized and then tackled by ND-solve (a numerical method in Mathematica) for solutions purposes. Entropy generation, concentration, velocity, Bejan number and temperature are plotted as functions of the involved physical parameters. It is noticed that higher Marangoni number intensify velocity however it causes a decrease in the temperature. Entropy rate and Bejan number boost for large value of diffusion parameter.