BackgroundOral health is closely related to general health awareness and good oral hygiene practices, which makes it an important aspect of general health and well-being. The current study assessed the knowledge, attitudes, and practices of oral hygiene among secondary school students in Al-Qunfudah district, Saudi Arabia.MethodsA convenient sample of 383 male and female secondary school students in the Al-Qunfudah district, Saudi Arabia, was included in this descriptive cross-sectional study. The research data were collected from the study sample through a self-administered online survey via WhatsApp and Telegram electronic applications. Finally, the collected data were coded and analyzed through the Statistical Package for the Social Sciences (SPSS) version 25.0 (SPSS Inc., Chicago, IL) and expressed in frequencies, percentages, mean, and standard deviation. The chi-squared and Fisher's exact tests were applied to assess the relationship between the participants' knowledge and practice scores of oral hygiene and their demographic characteristics. A P-value of less than 0.05 was regarded as significant.ResultsIn this study, female students represented 70% of the sample, and most of them were Saudi (97.0%). Many of them identified the great impact of oral hygiene on overall health (89.2%), and more than two-thirds indicated that brushing their teeth regularly would prevent oral problems (89.2%). Nearly two-thirds of them perceived that dental problems would affect their school attendance; however, 59.1% ignored the important role of schools in maintaining students’ oral hygiene. The poor practice of dental care was observed among students, as 47.5% brush their teeth twice daily and a third replace their brushes every three months. Despite the fact that the majority of the study population had adequate knowledge (44.4%) and a positive attitude (78.6%) toward oral hygiene, only 39.9% could effectively apply it. The knowledge of oral hygiene was significantly better among females (P = 0.005), older students (P = 0.001), those at a higher academic level (P = 0.016), and students from Al-Qunfudah city (P = 0.007). Furthermore, older pupils, those with a higher academic level, and those from Al-Qunfudah city performed better in terms of dental hygiene than their peers (P-value was 0.001 for each).ConclusionSecondary school students generally have adequate awareness levels and positive attitudes toward oral hygiene, but they practice it with remarkably little consistency. Schools should emphasize their crucial roles in enhancing oral health among their students of different education levels through their curriculum and frequent monitoring of students. Persuasive and realistic oral health education initiatives are recommended for schoolchildren and their family members or caregivers, with a particular emphasis on males, younger children, and those living in rural areas.