AbstractMost pancreatoduodenectomy (PD) procedures for locally advanced pancreatic head adenocarcinoma (PDAC) require superior mesenteric/portal vein (SMV/PV) axis resection and reconstruction. Here we describe the inverted Y‐shaped as a new technique for complex SMV/PV reconstruction and aimed at evaluating its safety and effectiveness. Among 287 patients who underwent PD for locally advanced PDAC from April, 2007 to December, 2020 at our hospital, 11 patients (3.8%) who underwent PV/SMV reconstruction with this technique were enrolled. Briefly, two distal veins were slit‐wedged, sutured, resulting in one orifice, then reconstruction was completed with (n= 6) or without (n= 5) interposed autologous right external iliac vein (REIV) grafts, respectively. Operation time and blood loss were 649 (502–822) min and 1782 (475–6680) mL, respectively. The median length of resected SMV/PV was 40 (20–70) mm, 50 (50–70) mm for REIV grafts, and the splenic vein was resected in eight patients. No patient developed pancreatic fistula; mild leg edema was observed in the six graft patients and the median hospital stay was 36.0 d. PV patency rate at 2 mo after PD was 91% (10/11) and no 90‐d mortality was recorded. R0 resection rate was 91% (10/11). It is feasible to safely reconstruct the SMV/PV using the inverted Y‐shaped technique in appropriately selected PDAC patients.