The co-existence of the colistin resistance (mcr) gene with multiple drug-resistance genes has raised concerns about the possibility of the development of pan-drug-resistant bacteria that will complicate treatment. This study aimed to investigate the antibiotic resistance profiles and co-existence of antibiotic resistance genes among the colistin-resistantEnterobacteriaceaeisolates recovered from poultry and poultry meats. The antibiotic susceptibility to various classes of antibiotics was performed using the Kirby-Bauer disk diffusion method and selected antimicrobial resistance genes were detected using PCR in a total of 54 colistin-resistantEnterobacteriaceaeisolates includingEscherichia coli(E.coli) (n = 32),Salmonellaspp. (n = 16) andKlebsiella pneumoniae(K.pneumoniae) (n = 6) isolates. Most of the isolates had multi-drug resistance (MDR), with antibiotic resistance against up to seven classes of antibiotics. Allmcr-harbouring, colistin-resistantEnterobacteriaceaeisolates showed this MDR (100%) phenotype. Themcr-1harbouringE.coliisolates were co-harbouring multiple antibiotic resistance genes. The seven most commonly identified resistance genes (blaTEM,tetA,floR,aac-3-IV,aadA1,fosA,aac(6_)-lb) were detected in anmcr-1-harbouringE.coliisolate recovered from a cloacal swab. Themcr-5harbouringSalmonellaspp. isolate recovered from poultry meats was positive forblaTEM,tetA,floR,aac-3-IV,fosAandaac(6_)-lbgenes. In conclusion, the colistin-resistantEnterobacteriaceaewithmcrgenes co-existing multiple clinically important antimicrobial resistance genes in poultry and poultry meats may cause potential future threats to infection treatment choices in humans and animals.