ABSTRACTThis study examined the 10‐year trends in the prevalence of osteoporosis according to disability grade and type compared with those without disabilities in South Korea. We linked national disability registration data with the National Health Insurance claims data. Age‐ and sex‐standardized prevalence of osteoporosis were analyzed from 2008 to 2017 according to sex, disability type, and disability grade. Adjusted odds ratios for osteoporosis according to disability characteristics in the most recent years' data were also confirmed by multivariate analysis. Over the past decade, the prevalence of osteoporosis has increased in people with disabilities compared with people without disabilities, and the gap has gradually widened from 7% to 15%. By analysis of the most recent year data, both male and female individuals with disabilities had a higher risk of osteoporosis than those without disability (odds ratios [OR] 1.72, 95% confidence interval [CI] 1.70–1.73 in males; OR 1.28, 95% CI 1.27–1.28 in females); the multivariate‐adjusted OR was especially prominent in disability related to respiratory disease (OR 2.07, 95% CI 1.93–2.21 in males; OR 1.74; 95% CI 1.60–1.90 in females), epilepsy (OR 2.16, 95% CI 1.78–2.61 in males; OR 1.71; 95% CI 1.53–1.91 in females), and physical disability types (OR 2.09, 95% CI 2.06–2.21 in males; OR 1.70; 95% CI 1.69–1.71 in females). In conclusion, the prevalence and risk of osteoporosis have increased in people with disabilities in Korea. In particular, the risk of osteoporosis increases significantly in people with respiratory diseases, epilepsy, and physical disability types. © 2023 The Authors.JBMR Pluspublished by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.