We have developed a new three-component catalytic coupling
reaction
of alkynyl boronates, diazomethanes, and aliphatic/aromatic ketones
in the presence of BINOL derivatives. The reaction proceeds with a
remarkably high enantio- and diastereoselectivity (up to three contiguous
stereocenters) affording tertiary CF3-allenols in a single
operational step. The reaction proceeds under mild, neutral, metal-free
conditions, which leads to a high level of functional group tolerance.