Within the scope of this research, a new short-time procedure designated asStressLifeHCFwas developed. Through a combination of classic fatigue testing and non-destructive monitoring of the material response due to cyclic loading, a process-oriented fatigue life determination can be carried out. A total of two load increases and two constant amplitude tests are required for this procedure. By using data from non-destructive measurements, the parameters of the elastic approach according to Basquin and the plastic approach according to Manson–Coffin were determined and combined within theStressLifeHCFcalculation. Furthermore, two additional variations of theStressLifeHCFmethod were developed in order to be able to accurately describe the S-N curve over a wider range. The main focus of this research was 20MnMoNi5-5 steel, which is a ferritic-bainitic steel (1.6310). This steel is widely used for spraylines in German nuclear power plants. In order to validate the findings, tests were also performed on an SAE 1045 steel (1.1191).