BackgroundWearable powered exoskeletons represent a promising rehabilitation tool for locomotor training in various populations, including in individuals with a spinal cord injury. The lack of clear evidence on how to implement a locomotor powered exoskeleton training program raises many challenges for patients, clinicians and organizations.ObjectiveTo report determinants of implementation in clinical practice of an overground powered exoskeleton locomotor training program for persons with a spinal cord injury.Data sourcesMedline, CINAHL, Web of Science.Study selectionStudies were included if they documented determinants of implementation of an overground powered exoskeleton locomotor training program for individuals with spinal cord injury.Data extractionEligible studies were identified by two independent reviewers. Data were extracted by one reviewer, based on constructs of the Consolidated Framework for Implementation Research, and validated by a second reviewer.ResultsSixty-three articles were included. 49.4% of all determinants identified were related to the intervention characteristics, 29.6% to the individuals’ characteristic and 13.5% to the inner setting. Recurrent barriers identified were the high prevalence of adverse events (e.g., skin issues, falls) and device malfunctions. Adequate training for clinicians, time and resource available, as well as discussion about patients’ expectations were identified as facilitators.ConclusionsPowered exoskeleton training is a complex intervention. The limited information on the context and the implementation process domains may represent a barrier to a successful transition from knowledge to action.