BackgroundPatient motivation is an important determinant of rehabilitation outcomes. Differences in patients’ and clinicians’ perceptions of motivational factors can potentially hinder patient-centered care. Therefore, we aimed to compare patients’ and clinicians’ perceptions of the most important factors in motivating patients for rehabilitation.MethodsThis multicenter explanatory survey research was conducted from January to March 2022. In 13 hospitals with an intensive inpatient rehabilitation ward, 479 patients with neurological or orthopedic disorders undergoing inpatient rehabilitation and 401 clinicians, including physicians, physical therapists, occupational therapists, and speech-language-hearing therapists, were purposively selected using inclusion criteria. The participants were asked to choose the most important factor motivating patients for rehabilitation from a list of potential motivational factors.ResultsHere we show that realization of recovery, goal setting, and practice related to the patient’s experience and lifestyle are the three factors most frequently selected as most important by patients and clinicians. Only five factors are rated as most important by 5% of clinicians, whereas nine factors are selected by 5% of patients. Of these nine motivational factors, medical information (p< 0.001; phi = −0.14; 95% confidence interval = −0.20 to −0.07) and control of task difficulty (p= 0.011; phi = −0.09; 95% confidence interval = −0.16 to −0.02) are selected by a significantly higher proportion of patients than clinicians.ConclusionsThese results suggest that when determining motivational strategies, rehabilitation clinicians should consider individual patient preferences in addition to using the core motivational factors supported by both parties.