AbstractDrought and heat stress are major abiotic stress factors that limit photosynthesis and other related metabolic processes that hamper plant growth and productivity. Identifying plants that can tolerate abiotic stress conditions is essential for sustainable agriculture.Amaranthusplants can tolerate adverse weather conditions, especially drought and heat, and their leaves and grain are highly nutritious. Because of these traits, amaranth has been identified as a possible crop to be grown in marginal crop production systems. Therefore, this study investigated the photochemical and biochemical responses ofAmaranthus caudatus,Amaranthus hypochondriacus,Amaranthus cruentus, andAmaranthus spinosusto drought stress, heat shock treatments, and a combination of both. After the six‐leaf stage in a greenhouse, plants were subjected to drought stress, heat shock treatments, and a combination of both. Chlorophyllafluorescence was used to evaluate the photochemical responses of photosystem II to heat shock while subjected to drought stress. It was found that heat shock and a combination of drought and heat shock damages photosystem II, but the level of damage varies considerably between the species. We concluded thatA. cruentusandA. spinosusare more heat and drought‐tolerant thanAmaranthus caudatusandAmaranthus hypochondriacus.