Drought is a complex natural hazard which can create significant impacts on society and environment. Given that this phenomenon varies across space and changes over time dependent on various factors (e.g., physical conditions and human activities), the available of spatiotemporal drought data enables a better monitoring and assessment of drought severity This study introduced the integrated multivariate drought index (iMDI) data, a new regional drought index, at 1 km spatial and monthly temporal resolutions for the Vietnamese Central Highlands over a 20-years period. The iMDI was developed recently which is a combination of vegetation condition index (VCI), the temperature condition index (TCI), and the evaporative stress index (ESI) based on the feature of scaling algorithms (i.e., normalisations and standardisation). The data were processed using the median values of MODIS time-series imagery obtained from the Google Earth Engine (GEE) platform. The iMDI datasets are available for monthly and annual drought monitoring between 2001 and 2020. Additionally, the datasets of VCI, TCI, and ESI were provided so that users can apply for their own purposes even though these data can directly obtain from GEE or other sources. Users, especially those without technical expertise, can reap the advantages of having open access to iDMI data. By doing so, they can reduce their expenses and the time required to process data. As such, this accessibility can promote the use of data for diverse applications, such as evaluating the impact of droughts on the environment and human activities and monitoring droughts regionally.