PurposeEating disorders (EDs) are psychiatric disorders with a typical prevalence in adolescence. EDs have long been wrongly considered female gender-bound disorders, resulting in a systematic underrepresentation of males in EDs research. The main goal of the present study is exploring the clinical and psychological characteristics of adolescent males with EDs in comparison with females.MethodsIn this observational and retrospective study, 14 males and 28 females hospitalized for eating disorders during the adolescent age (from 12 to 17.11 years) were recruited. Main clinical data (age, BMI, duration of illness), behavioural characteristic of the disorder (over-exercising, self-harm, purging-behaviours) and psychological symptoms (Eating Disorders Inventory-3rd edition—EDI-3, Symptom Checklist-90-Revised—SCL-90, Children’s Global Assessment Scale—C-GAS) were collected and examined for significant correlations with severity of body mass index (BMI).ResultsAdolescent males show a peculiar and more severe psychopathological profiles partially influenced by BMI and characterized by purging-behaviours, over-exercising, obsessive–compulsive behaviour, anxiety, and psychoticism.ConclusionThis study suggests a gender-specific profile of adolescent males with EDs, which may be considered in diagnosis and treatment.Level IIIEvidence obtained from retrospective well-designed case–control study.