AbstractObjectivesThe risk and beneficial factors of early discharge after thoracoscopic anatomic lung cancer surgery are unknown, and this study aims to investigate predictors and associated 30‐day readmission for early discharge.MethodsWe performed a single‐center retrospective analysis of 10,834 consecutive patients who underwent thoracoscopic anatomic lung cancer surgery. Two groups were determined based on discharge date: “discharged by postoperative Day 2” and “discharged after postoperative Day 2.” Univariable and multivariable analysis were conducted to identify predictors for discharge. Using propensity score matching (PSM) to compare 30‐day readmission rate between two cohorts.ResultsA total of 1911 patients were discharged by postoperative Day 2. Multivariable analysis identified older age (odds ratio (OR) = 1.014,p< 0.001), male sex (OR = 1.183,p= 0.003), larger tumor size (OR = 1.248,p< 0.001), pleural adhesions (OR = 1.638,p= 0.043), lymph nodes calcification (OR = 1.443,p= 0.009), advanced clinical T stage (vs.T< 2, OR = 1.470,p= 0.010), lobectomy resection (vs. segmentectomy resection, OR = 2.145,p< 0.001) and prolonged operative time (OR = 1.011,p< 0.001) as independent risk factors for discharge after postoperative Day 2. Three adjustable variables including higher FEV1/FVC (OR = 0.989,p= 0.001), general anesthesia (GA) plus thoracic paravertebral blockade (vs. GA alone, OR = 0.823,p= 0.006) and uni‐portal thoracoscopic surgery (vs. multi‐portal, OR = 0.349,p< 0.001) were associated with a decreased likelihood of discharge after postoperative Day 2. Before and after a 1:1 PSM, discharged by postoperative Day 2 did not increase the risk of 30‐day readmission compared to counterparts.ConclusionsCarefully selected patients can be safely discharged within 2 days after thoracoscopic anatomic lung cancer surgery. Three modifiable variables may be favorable for promoting discharge by postoperative Day 2.