Alcoholism is a worldwide health problem, and diseases caused by alcoholism are killing people every year.Amomum kravanhis a traditional Chinese medicine used to relieve hangovers. However, whether its bioactive components improve alcohol metabolism is not clear. In this study, ten new (amomumols A-J,1–10) and thirty-five known (11–45) compounds were isolated from the fruits ofAmomum kravanhby an activity-guided separation. Ten novel compounds were identified as four sesquiterpenoids (1–4), three monoterpene derivatives (5–7), two neolignans (8,9), and a novel norsesquiterpenoid (10) with a new C14nor-bisabolane skeleton. Their structures were determined by the comprehensive analysis of high-resolution electrospray ionization mass spectrometry (HRESIMS), nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD) calculation. The effects of all isolated compounds on the activity of alcohol dehydrogenase were evaluated in vitro, and it was found that eight compounds (11,12,15,18,26, and36–38) exhibited significant activation effects on the alcohol dehydrogenase at 50 μM.