SUMMARYIn this review, we summarize the current state of knowledge on the fat mass and obesity-associated (FTO) gene and its role in obesity. The FTO-encoded protein is involved in multiple molecular pathways contributing to obesity as well as other metabolic complexities. This review emphasizes the epigenetic influence on theFTOgene as a new approach in the treatment and management of obesity. Several known substances have a positive effect on reducingFTOexpression. Depending on which variant of the single nucleotide polymorphism (SNP) is present, the profile and level of gene expression changes. Implementation of environmental change measures could lead to reduced phenotypic manifestation ofFTOexpression. Treating obesity throughFTOgene regulation will have to include various complex signal pathways in whichFTOtakes part. Identification ofFTOgene polymorphisms may be useful for the development of individual obesity management strategies, including the recommendation of taking certain foods and supplements.