Women economic potential can be used to reduce household’s food insecurity in sub-Saharan Africa. This study analyzed the influence of gender on household’s food security through the household’s income in North-Benin. We selected 300 households using a multistage sampling technique. Data were collected using a questionnaire during direct interviews. Data included the households’ socioeconomic characteristics, their experiences-based Food Insecurity Scale, women and men income level. Data were analyzed using descriptive statistics and generalized structural equation modeling. The findings show that women-headed households (WHH) were less exposed to food insecurity than men-headed households (MHH). Moreover, the increasing of women income level reduced the exposure of households to food insecurity, because the increase in the income level of women stimulated the men income level. Women income also contributed more to household food expenses than men income. However, the increasing of men income level exposed the households to food insecurity. These results highlight the importance of women's empowerment in addressing household food insecurity in African’s developing countries. The findings also help policy makers to improve their knowledge for better decision making on household food security.