Frictional pressure drop has been grasping the attention of many industrial applications associated with multi-phase and academia. Alongside the United Nations, the 2030 Agenda for Sustainable Development calls for the exigency of giving attention to economic growth, a considerable reduction in power consumption is necessary to co-up with this vision and to adhere to energy-efficient practices. Thereinto, drag-reducing polymers (DRPs), which do not require additional infrastructure, are a much better option for increasing energy efficiency in a series of critical industrial applications. Therefore, this study evaluates the effects of two DRPs—polar water-soluble polyacrylamide (DRP-WS) and nonpolar oil-soluble polyisobutylene (DRP-OS)—on energy efficiency for single-phase water and oil flows, two-phase air–water and air-oil flows, and three-phase air–oil–water flow. The experiments were conducted using two different pipelines; horizontal polyvinyl chloride with an inner diameter of 22.5 mm and horizontal stainless steel with a 10.16 mm internal diameter. The energy-efficiency metrics are performed by investigating the head loss, percentage saving in energy consumption (both per unit pipe length), and throughput improvement percentage (%TI). The larger pipe diameter was used in experiments for both DRPs, and it was discovered that despite the type of flow or variations in liquid and air flow rates, there was a reduction in head loss, an increase in energy savings, and an increase in the throughput improvement percentage. In particular, DRP-WS is found to be more promising as an energy saver and the consequent savings in the infrastructure cost. Hence, equivalent experiments of DRP-WS in two-phase air–water flow using a smaller pipe diameter show that the head loss drastically increases. However, the percentage saving in power consumption and throughput improvement percentage is significantly compared with that found in the larger pipe. Thus, this study found that DRPs can improve energy efficiency in various industrial applications, with DRP-WS being particularly promising as an energy saver. However, the effectiveness of these polymers may vary depending on the flow type and pipe diameter.