The current work experimentally determined how the initial resistance and gauge factor in additively manufactured piezoresistive sensors are affected by the material, design, and process parameters. This was achieved through the tensile testing of sensors manufactured with different infill angles, layer heights, and sensor thicknesses using two conductive polymer composites. Linear regression models were then used to analyze which of the input parameters had significant effects on the sensor properties and which interaction effects existed. The findings demonstrated that the initial resistance in both materials was strongly dependent on the sensor geometry, decreasing as the cross-sectional area was increased. The resistance was also significantly influenced by the layer height and the infill angle, with the best variants achieving a resistance that was, on average, 22.3% to 66.5% lower than less-favorable combinations, depending on the material. The gauge factor was most significantly affected by the infill angle and, depending on the material, by the layer height. Of particular interest was the finding that increasing in the infill angle resulted in an increase in the sensitivity that outweighed the associated increase in the initial resistance, thereby improving the gauge factor by 30.7% to 114.6%, depending on the material.