Dengue fever remains a significant public health concern in many tropical and subtropical countries, and there is still a need for a system that can effectively combine global risk assessment with timely incidence forecasting. This research describes an integrated application called PICTUREE—Aedes, which can collect and analyze dengue-related data, display simulation results, and forecast outbreak incidence. PICTUREE—Aedes automatically updates global temperature and precipitation data and contains historical records of dengue incidence (1960–2012) andAedesmosquito occurrences (1960–2014) in its database. The application utilizes a mosquito population model to estimate mosquito abundance, dengue reproduction number, and dengue risk. To predict future dengue outbreak incidence, PICTUREE—Aedes applies various forecasting techniques, including the ensemble Kalman filter, recurrent neural network, particle filter, and super ensemble forecast, which are all based on user-entered case data. The PICTUREE—Aedes’ risk estimation identifies favorable conditions for potential dengue outbreaks, and its forecasting accuracy is validated by available outbreak data from Cambodia.