Influenza viruses are respiratory pathogens that are major threats to human health. Due to the emergence of drug-resistant strains, the use of traditional anti-influenza drugs has been hindered. Therefore, the development of new antiviral drugs is critical. In this article, AgBiS2nanoparticles were synthesized at room temperature, using the bimetallic properties of the material itself to explore its inhibitory effect on the influenza virus. By comparing the synthesized Bi2S3and Ag2S nanoparticles, it is found that after adding the silver element, the synthesized AgBiS2nanoparticles have a significantly better inhibitory effect on influenza virus infection than Bi2S3and Ag2S nanoparticles. Recent studies have shown that the inhibitory effect of AgBiS2nanoparticles on the influenza virus mainly occurs in the stages of influenza virus-cell internalization and intracellular replication. In addition, it is found that AgBiS2nanoparticles also have prominent antiviral properties against α and β coronaviruses, indicating that AgBiS2nanoparticles have significant potential in inhibiting viral activity.