 No significant reactivity is demonstrated with melanoma marker HMB-45 or Melan-A.  Tumor cell nuclei (spindle cell and pleomorphic/giant cell carcinoma components) show nuclear reactivity with thyroid transcription factor marker (TTF-1). 
No significant reactivity is demonstrated with melanoma marker HMB-45 or Melan - A. Tumor cell nuclei ( spindle cell and pleomorphic / giant cell carcinoma components ) show nuclear reactivity with thyroid transcription factor marker ( TTF-1 ) .