<s>[INST] context: R ifampin (Rifampicin, R): It is a semisynthetic derivative of rifamycin B Adverse effects :The incidence of adverse effects is similar to INH. Hepatitis, a major adverse effect, generally occurs in patients with preexisting liver disease and is dose-related: development of jaundice requires discontinuation of the drug-then it is reversible. Other serious but rare reactions are: * &;Respiratory syndrome&;: breathlessness which may be associated with shock and collapse. * Purpura, haemolysis, shock and renal failure. Minor reactions usually not requiring drug withdrawal and more common with intermittent regimens are: * &;Cutaneous syndrome&;: flushing, pruritus + rash (especially on face and scalp), redness and watering of eyes. * &;Flu syndrome&;: with chills, fever, headache, malaise and bone pain. * &;Abdominal syndrome&;: nausea, vomiting, abdominal cramps with or without diarrhoea. Urine and secretions may become orange-red but this is harmless. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:741,742 [/INST] question: ATT causing orange coloured urine is: | options: A: Rifampicin B: Isoniazid C: Streptomycin D: Pyrazinamide | answer: A </s>