<s>[INST] context: CLASSIFICATION 1.4-Aminoquinolines: Chloroquine, Amodiaquine, Piperaquine. 2.Quinoline-methanol :Mefloquine. 3.Cinchona alkaloid :Quinine, Quinidine 4.Biguanides :Proguanil (Chloroguanide) Chlorproguanil 5. Diaminopyrimidines Pyrimethamine 6. 8-Aminoquinoline :Primaquine, Bulaquine 7.Sulfonamides and sulfone: Sulfadoxine Sulfamethopyrazine Dapsone 8. Tetracyclines:Tetracycline, Doxycycline 9. Sesquiterpine lactones:Aesunate, Aemether, Aeether 1 0. Amino alcohols:Halofantrine, Lumefantrine 1 1 . Mannich base:Pyronaridine 1 2. Naphthoquinone:Atovaquone 1. Aesunate-sulfadoxine + pyrimethamine (AS/5/P) This ACT has been adopted as the first line drug for falciparum malaria in chloroquineresistant areas under the &;National antimalaria drug policy&; of India, and has replaced chloroquine in 73 districts. However, this does not imply that it is the most effective/best ACT, because it is not effective against multidrugresistant strains which are nonresponsive to S/P. Moreover, no comparative evaluation of this regimen against AS/MQ or aemether/ lumefantrine, etc. has been done to establish the relative efficacy /tolerability. 2. Aesunate-mefloquine (AS/MQ) It has been extensively used in Thailand, Myanmar and several other countries; found to be highly effective, well tolerated and is now the first line treatment for uncomplicated falciparum malaria in Southeast Asia. Many areas in the far East already have mefloquine-resistant P. falciparum. By combining with aesunate, fuher spread of mefloquine-resistance has been prevented ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:781,795 [/INST] question: Most effective treatment for severe malaria is: | options: A: Aesunate B: Chloroquine C: Quinine D: Primaquine | answer: A </s>