<s>[INST] context: Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. In people with healthy bones, new bone is always replacing old bone. In osteonecrosis, the lack of blood causes the bone to break down faster than the body can make enough new bone . The most common causes of osteonecrosis are: Serious trauma (injury), which interrupts a bone's blood supply Coicosteroid medications (such as prednisone, coisone or methylprednisolone), mainly when a high dose is used for a prolonged period of time Excess alcohol consumption SLE Other less common risk factors for osteonecrosis include: Decompression disease (also called the "Bends" that can occur with scuba diving) Blood disorders such as sickle cell anemia, antiphospholipid antibody syndrome (APS) and lupus anticoagulant HIV infection (the virus that causes AIDS) Radiation therapy Bisphosphonates, which may be linked to osteonecrosis of the jaw Organ transplants REf - Harrisons internal medicine 20e p2617t , 225, 677, 2936, 2955 , 1441 [/INST] question: Which of the following cause osteonecrosis - | options: A: Sickle cell anemia B: Coicosteroid use C: Die D: SLE | answer: D </s>