<s>[INST] context: Risk factors for Colon cancer

Dietay factures - explainaed in previous quetion
Hereditary factors
	Polyposis coli 
	Nonopolyposis herditary colon cancer ( also known as Lynch syndrome)
Inflammatory bowel disease
	- Long standing IBD increases the risk
	- Risk is more with ulcerative colitis than crohn's disese.
	- Risk increases with the duration and extent of colitis.

	4. Streptococcus bovis bacteremia


Individuals who develop endocarditis or septicemia from this bacteria, have a high incidence of occult colorectal tumors and passibly upper GI cancers also.

	5. Other Risk factors
	(a) Ureterosiginoidostomy
	(b) Cigarette smoking - is linked to the development of colorectal adenomas , particularly after >35 yrs of use.
(c) Acromegaly
	(d) Pelvic irradiation
Aspirin & other NSAIDs use has been foud to have a protective effect (Chemopervention)
Other substance found to have chemoprentive action are → Oral folic acid supplementation, Oral calcium supplementation, Estrogen replacement therapy. [/INST] question: Which of these are associated with increased risk of colorectal Ca -a)  More intake of animal fatb)  Aspirinc)  Ulcerative colitisd)  Amoebic colitise)  Polyps | options: A: acd B: bde C: cde D: ace | answer: D </s>