<s>[INST] context: Essential hypeension tends to be familial and is likely to be the consequence of an interaction between environmental and genetic factors. The prevalence of essential hypeension increases with age, and individuals with relatively high blood pressures at younger ages are at increased risk for the subsequent development of hypeension.It is likely that essential hypeension represents a spectrum of disorders with different underlying pathophysiologies. In the majority of patients with established hypeension, peripheral resistance is increased and cardiac output is normal or decreased; however, in younger patients with mild or labile hypeension, cardiac output may be increased and peripheral resistance may be normal. When plasma renin activity (PRA) is plotted against 24-h sodium excretion, ~10-15% of hypeensive patients have high PRA and25% have low PRA. High-renin patients may have a vasoconstrictor form of hypeension, whereas low-renin patients may have volumedependent hypeension. Inconsistent associations between plasma aldosterone and blood pressure have been described in patients with essential hypeension.. ref:Harrison&;s principles of internal medicine,ed 18,pg no 2048 [/INST] question: In essential hypeention changes seen in the hea are- | options: A: Cardiac cell hyperplasia B: Cardiac cell hyperophy C: increse in the mitochondrial number D: Increase in size of mitochondria | answer: B </s>