<s>[INST] context: Explanation:
Juvenile Papillomatosis of the breast
● It is a relatively common benign localised proliferative lesion in the breast.
● It is mainly seen in young women (mean age: 19-23 years)
● Caused by HPV 6 and 11.
Clinical presentation
● Patients present with a firmt well-defined, mobile mass often in the periphery of the breast.
● There is usually no nipple discharge.
Pathology
● Papillary proliferation of the ductal epithelium which partly fills up smaller ducts causing distension.
● Grossly, well-circumscribed mass containing multiple small cysts (<2 cm) within a dense fibrous stroma
(therefore sometimes termed swiss cheese disease by pathologists).
● Lesions can vary in size, usually ranging from 1 to 8 cm.
Radiographic features
Breast ultrasound
● They can appear as an ill-defined, inhomogenous hypoechoic mass with multiple small (up to 4mm) predominantly peripheral cysts.
● Microcalcifications may be seen at sonography.
Mammography
● These lesions are usually negative on mammography.
● Occasionally may show microcalcifications, an asymmetric density or a prominant intraductal pattern. 
Galactography
● May show a multiple irregular filling defects within the breasts. Breast MRI
Signal characteristics according to one report include
● T1 : hypo-intense lobulated mass
● T2 : may show- presence of multiple small internal cysts, best shown on this sequence and is considered the most specific feature
● T1 C+ (Gd) : may or may not show marked rapid enhancement
● Dynamic sequence: shows a benign enhancement profile.
Complications
● Despite being a benign entity, it is considered by some to be a marker for familial breast cancer.
● Approximately /0% develop breast cancer later in life. [/INST] question: Type of human papilloma virus associated with cacinoma cervix | options: A: Types 6, 12, 18 B: Types 16, 18, 31 C: Types 6, 8, 11 D: Types 3, 10, 19 | answer: B </s>