<s>[INST] context: Propylthiouracil Propylthiouracil is the drug of choice for hypehyroidism during pregnancy. Antithyroid drugs in pregnancy Propylthiouracil and methirnezole are both antithyroid drugs that cross the placenta and can lead to fetal goiter. Methimazole has been associated with "cutis aplasia". Scalp defects cloanal atresia esophageal atresia and increased maternal side effects. Because both medications are equally effective the drug of choice for hypehyroidism in pregnancy is propylthiouracil. Propylthiouracil is not available throughout the world and in those conditions methimazole may be substituted. Antihypeensives in pregnancy Angiotensin conveing enzyme inhibitor (ACE inhibitor) e.g., Enalapril, captopril can cause fetal renal tubular dysplasia in the second and third trimesters leading to oligohydramenios fetal limb contractures, craniofacial deformities and hypoplastic lung development. A recent large coho study found an increased risk of congenital malformations with isolated first trimester exposure to ACE inhibitors. Infants exposed in utero to ACE inhibitors were at increased risk of cardiovascular and CNS malformations. Angiotensin II receptor antagonists have been shown to have second and third trimester findings consistent with ACE inhibitors and are not recommended in pregnancy. Aldosterone We have not got any literature on the use of Aldosterone during pregnancy. We are not sure of it use during pregnancy. [/INST] question: Which can be used in pregnancy aEUR' | options: A: >ACE inhibitors B: >Aldosterone C: >AT receptor antagonist D: >Propylthiouracil | answer: D </s>