The major site of action in the nephron appears on an electroneutral Na+-Cl co-transporter by competing for the chloride site on the transporter.
Goobta ugu weyn ee waxqabadka nephron-ka waxay ka muuqataa koronto-wadaha Na + -Cl wada-qaadaha iyadoo loo tartamayo goobta chloride-ka ee xamuulka.