The reaction of the drug and physical dependence of the human body was first observed by Hollister and his collaborators in 1963 while they were studying the treatment of schizophrenic patients with diazepam.
Dareen-celinta daroogada iyo ku tiirsanaanta jireed ee jirka bini'aadamka waxaa markii ugu horreysay arkay Hollister iyo la-hawlgalayaashiisii   1963-kii markii ay baranayeen daaweynta bukaannada shisoofran ee loo yaqaan 'diazepam'.