 Lidocaine, የመጀመሪያው አሚኖ amide-ዓይነት የአካባቢ ማደንዘዣ, ለመጀመሪያ ጊዜ በ 1943 ስዊድናዊ የኬሚስትሪ ኒልስ Lofgren በ ስም xylocaine ስር ተሰብስቦ በተሰራ ነበር የእሱ የሥራ ባልደረባዬ Bengt Lundqvist ውስጥ በግምት 95% (dealkylated) metabolized himself.
Lidocaine wa, woyamba kwa amino amide-mtundu mankhwala ochititsa m'deralo, anali woyamba apanga pansi pa dzina xylocaine ndi Swedish sayansi Nils Lofgren mu 1943. mnzake Wake Bengt Lundqvist anachita woyamba zatsopano jekeseni mankhwala ochititsa dzanzi pa himself.Lidocaine ndi pafupifupi 95% zimapukusidwa (dealkylated) mu chiwindi ndi CYP3A4 kwa metabolites pharmacologically-yogwira monoethylglycinexylidide (MEGX) ndi ndiye kenako kwa anafooka glycine xylidide.