Since metformin is excreted by the kidneys, it is necessary to determine creatinine clearance before starting treatment and regularly thereafter: at least once a year in patients with normal renal function and 2-4 times a year in elderly patients, as well as in patients with Cl creatinine on NGN.
Njengoba i-metformin idlulwa yizinso, ngaphambi kokuqala ukwelashwa, futhi njalo ngemuva kwalokho, kuyadingeka ukuthola i-QC: okungenani isikhathi esisodwa ngonyaka ezigulini ezinomsebenzi ojwayelekile wezinso, kanye nezikhathi ezi-2-4 ngonyaka ezigulini esezikhulile, kanye nasezigulini ezine-CC ku umkhawulo ophansi wokujwayelekile.