Santa Ana has approximately 274,830 (2006) inhabitants and serves both as the capital of the department of Santa Ana and as the municipal seat for the surrounding municipality of the same name.
ISanta Ana inabantu ababalelwa ku-374,830 futhi isebenza njengenhloko-dolobha yomnyango waseSanta Ana futhi njengesihlalo sikamasipala kamasipala oseduze wegama elifanayo.