 Lidocaine, የመጀመሪያው አሚኖ amide-ዓይነት የአካባቢ ማደንዘዣ, ለመጀመሪያ ጊዜ በ 1943 ስዊድናዊ የኬሚስትሪ ኒልስ Lofgren በ ስም xylocaine ስር ተሰብስቦ በተሰራ ነበር የእሱ የሥራ ባልደረባዬ Bengt Lundqvist ውስጥ በግምት 95% (dealkylated) metabolized himself.
Lidocaine, acid amide-uhlobo lokudoma wokuqala, ukuba kuhlelwe kuqala phantsi kwegama lo xylocaine ngu semichiza Swedish Nils Lofgren ngo-1943 asebenza naye Bengt Lundqvist wayesenza yemifuniselo yokuqala isitofu zomzimba kwi himself.Lidocaine yi malunga ne-95% umzimba (dealkylated) kwi isibindi yi CYP3A4 ukuya metabolites pharmacologically-esebenzayo monoethylglycinexylidide (MEGX) uze emva koko ukuya glycine xylidide engasebenziyo.