Short-term treatment outcome of pulpotomies in primary molars using mineral trioxide aggregate and Biodentine: a randomized clinical trial Clinical Evaluation of Success of Primary Teeth Pulpotomy Using Mineral Trioxide Aggregate(®), Laser and Biodentine(TM)- an In Vivo Study. Evaluation and comparison of mineral trioxide aggregate and biodentine in primary tooth pulpotomy: Clinical and radiographic study Long-term evaluation of pulpotomy in primary molars using mineral trioxide aggregate or formocresol. The Clinical and Radiographic Success of Primary Molar Pulpotomy Using Biodentine™ and Mineral Trioxide Aggregate: A 24-Month Randomized Clinical Trial. Clinical and radiographical evaluation of mineral trioxide aggregate, biodentine and propolis as pulpotomy medicaments in primary teeth The evaluation of MTA and Biodentine as a pulpotomy materials for carious exposures in primary teeth Effect of mineral trioxide aggregate and formocresol pulpotomy on vital primary teeth: a clinical and radiographic study. Clinical and radiographic comparison of biodentine, mineral trioxide aggregate and formocresol as pulpotomy agents in primary molars Mineral trioxide aggregate vs. formocresol in pulpotomized primary molars: a preliminary report. Pulpotomy in caries-exposed immature permanent molars using calcium-enriched mixture cement or mineral trioxide aggregate: a randomized clinical trial. Mineral Trioxide Aggregate vs. Calcium Hydroxide in Primary Molar Pulpotomy: A Systematic Review
Introduction An ideal pulpotomy agent for primary molars has been sought for many years . Recently , new material s that allow regeneration of residual pulp tissue have been developed . In this study , we compared the preliminary clinical results obtained using Biodentine and mineral trioxide aggregate ( MTA ) as pulp-dressing agents in pulpotomies of primary molars . Methods A r and omized clinical study was performed in children aged 4–9 years with at least one primary tooth with decay or caries requiring pulp treatment . A total of 90 primary molars requiring pulpotomy were r and omly allocated to the MTA or Biodentine group , and 84 pulpotomies were performed . Clinical and radiographic evaluations were undertaken 6 and 12 months after treatment . All teeth were restored with a reinforced zinc oxide – eugenol base and stainless steel crowns . Statistical analysis using Fisher ’s exact test was performed to determine the significant differences between the groups . Results A total of four clinical failures were observed ; all involved gingival inflammation . The clinical success rate in the MTA Group after 12 months was 92 % ( 36/39 ) , whereas the Biodentine Group obtained 97 % ( 38/39 ) ( p = 0.346 ) . All radiographic failures were observed at the 12-month follow-up evaluation . One molar from MTA Group showed internal resorption obtaining a radiographic success rate of 97 % ( 38/39 ) . Two molars from the Biodentine Group showed radiographic failure ( 1 internal resorption and 1 periradicular radiolucency ) obtaining a radiographic success rate of 95 % ( 37/39 ) . Conclusions Biodentine showed similar clinical results as MTA with comparable success rates when used for pulpotomies of primary molars . However , longer follow-up studies are required to confirm our findings . Clinical relevance This article demonstrates the effectiveness of Biodentine as a primary teeth pulpotomy material , performing similar results as MTA at 12-months evaluation INTRODUCTION Pulpotomy technique basically consists of removing the coronal pulp and fixing the radicular pulp with a medicament . It is the most widely accepted clinical procedure for treating primary teeth with coronal pulp inflammation caused by caries with no involvement of the radicular pulp . AIM To evaluate the success and efficacy of Mineral Trioxide Aggregate ( MTA ) , Lasers and Biodentine as pulpotomy agents both clinical ly and radiographically . MATERIAL S AND METHODS In the present study , 60 primary molars in children whose pulpal status warranted pulpotomy were selected and r and omly assigned into three groups that included MTA , Laser and Biodentine allocating 20 teeth to each group . The pulpotomy procedure was then performed on all selected teeth followed by restoration with stainless steel crowns . Later the patients were recalled for 3 months and 6 months for clinical and radiographic evaluation . RESULTS Statistical analysis was done using Fisher exact test to determine pair wise comparison of three agents with respect to clinical and radiographic criteria . Kruskal-Wallis ANOVA , Mc Nemars test was applied to evaluate the efficacy of each agent between 3 months and 6 months . The results showed that maximum success rate was found in MTA group . However , the comparison between three groups was statistically not significant ( p<0.05 ) . CONCLUSION Pulpotomies performed with either MTA , Laser or Biodentine are equally efficient with similar clinical /radiographic success and hence can be considered as alternatives to Formocresol Objectives : Pulpotomy is the common therapy for cariously exposed pulps in symptom-free primary molar teeth . For many years , research ers have search ed for an ideal material that allows regeneration of the residual pulp . The purpose of this study was to evaluate the efficacy of mineral trioxide aggregate ( MTA ) , Biodentine as a pulpotomy medicament in primary teeth , both clinical ly and radiographically . Material s and Methods : A total of 25 children ( 50 human primary molar teeth ) aged between 5 and 9 years were selected in this r and omized clinical study . The patients were r and omly assigned to receive the pulpotomy medicaments in either [ Group 1 ] : MTA or [ Group 2 ] : Biodentine . All pulpotomized teeth were restored with stainless steel crowns and evaluated clinical ly and radiologically at 1 , 3 , 6 and 12 months . Statistical analysis using Mann – Whitney U test and Fisher 's exact test , and chi-square test was performed to determine the significant differences between the groups . Results : Clinical and radiological success rates were 96 and 80 % in Group 1 and 96 and 60 % in Group 2 , respectively . There were no significant differences between the groups ( P > 0.05 ) . The radiographic success rates decreased in the controls , but there were no significant differences . Conclusion : Biodentine showed similar clinical and radiographic results as MTA in the 12-month evaluation and can be safely used as a pulpotomy medicament PURPOSE The objective of this study was to assess the effect of mineral trioxide aggregate ( MTA ) as pulp dressing material following pulpotomy in primary molars with carious pulp exposure and compare them to those of formocresol ( FC ) . METHODS Of 33 children , primary molars treated via a conventional pulpotomy technique  were r and omly assigned to the MTA  group ( 33 teeth ) or FC  group ( 29 teeth ) . Clinical and radiographic follow-up ranged between 4 and 74 months . The mean follow-up time was 38 months , with no difference between the groups . Twenty-nine teeth were followed until uneventful shedding ( mean=33 months ) . Failures were detected after a mean period of 16 months ( range=4 to 30 ) . RESULTS The success rate of pulpotomy was 97 % for MTA ( 1 failure ) and 83 % for FC ( 5 failures ) . Eight teeth presented internal resorption . In 4 of them ( 2 of each group ) , progress of the resorption process stopped and the pulp tissue was replaced by a radioopaque calcified tissue . Pulp canal obliteration was observed in 58 % of the MTA group and in 52 % of the FC group ( total=55 % ) . CONCLUSIONS MTA showed a higher ( though not statistically significant ) long-term clinical and radiographic success rate than formocresol , and can be recommended as its replacement as , unlike FC , MTA does not induce undesirable responses PURPOSE The purpose of this study was to compare the clinical and radiographic success of Biodentine ™ and mineral trioxide aggregate ( MTA ) pulpotomy in primary molars . METHODS Thirty-two four- to nine-year-olds were included in this study . The primary molars were r and omly assigned to the Biodentine ™ and MTA groups . After coronal pulp removal and hemostasis , the remaining pulp tissue was covered with Biodentine ™ or MTA . All teeth were restored with stainless steel crowns . Clinical and radiographic successes and failures were recorded at six- , 12- , 18- and 24-month follow-ups . Data were statistically analyzed using Mann-Whitney U and Wilcoxon tests . RESULTS The 24-month follow-up evaluations revealed that the clinical success rates were 96.8 percent ( 30 out of 31 ) for both Biodentine ™ and MTA . The radiographic success rates at 24 months were 93.6 percent ( 29 out of 31 ) for Biodentine ™ and 87.1 percent ( 27 out of 31 ) for MTA . No significant differences were found among the groups at all follow-up appointments ( P>0.05 ) Conclusion : Biodentine ™ and mineral trioxide aggregate did not differ significantly in combined clinical and radiographic success after 24 months Objectives The purpose of this study was to evaluate the efficacy of mineral trioxide aggregate ( MTA ) , Biodentine and Propolis as pulpotomy medicaments in primary dentition , both clinical ly and radiographically . Material s and Methods A total of 75 healthy 3 to 10 yr old children each having at least one carious primary molar tooth were selected . R and om assignment of the pulpotomy medicaments was done as follows : Group I , MTA ; Group II , Biodentine ; Group III , Propolis . All the pulpotomized teeth were evaluated at 3 , 6 , and 9 mon clinical ly and radiographically , based on the scoring criteria system . Results The clinical success rates were found to be similar among the three groups at 3 and 6 mon where as a significant decrease in success rate was observed in Group III ( 84 % ) compared to both Group I ( 100 % ) and Group II ( 100 % ) at 9 mon . Radiographic success rates over a period of 9 mon in Groups I , II , and III were 92 , 80 , and 72 % , respectively . Conclusions Teeth treated with MTA and Biodentine showed more favorable clinical and radiographic success as compared to Propolis at 9 mon follow-up Objective This study examined the effects of MTA and Biodentine on the clinical and radiographic success rates of pulpotomies performed on primary teeth with carious pulp exposures . Material s and methods This study was conducted with 44 m and ibular primary molars requiring vital pulpotomy . Carious dentin surrounding the exposure site was used as the inclusion criteria for all teeth , which were r and omly divided into two groups according to pulpotomy material [ MTA group ( n = 24 ) , Biodentine group ( n = 20 ) ] . Treatment was followed up clinical ly and radiologically for 24 months . Pulp canal obliteration was not regarded as a failure . Results Clinical and radiographic success rates at the end of 24 months were 100 % for the MTA group and 89.4 % for the Biodentine group . Success rates did not vary significantly between the groups ( p = 0.646 ) . Pulp canal obliteration was observed in two teeth ( 8.3 % ) in the MTA group at 6 months , but the teeth were found to be stabilized by 24 months . Conclusion The long-term clinical and radiographic success rates obtained in this study indicate that both MTA and Biodentine are appropriate options for pulpotomy treatment of primary teeth with carious exposure in patients whose teeth should be retained for long periods of time . Clinical relevance The etiology of exposure determines pulpal response , making it crucial to distinguish between mechanical and carious exposures . The carious exposure is presumed to be accompanied by severe inflammation , which makes the prognosis of treatment unpredictable . Bio material s can be used especially in cases with carious pulp exposures BACKGROUND Pulpotomy is the common therapy for cariously exposed pulps in symptom-free primary molar teeth .  Formocresol ( FC ) is considered the gold st and ard dressing agent for pulpotomy , but concerns have been raised over the years about its safety . Other alternative pulpotomy agents have been investigated and suggested . OBJECTIVE The objective was to evaluate and compare the clinical and radiographic response of FC and white mineral trioxide aggregate ( MTA ) as pulpotomy material s on primary molars . MATERIAL S AND METHODS Fifty primary molars , with deep carious lesion that exposed a vital but asymptomatic pulp , in 37 children aged 4 - 7 years were treated with conventional pulpotomy procedure .  The teeth were divided r and omly into two groups . Group I ( FC ) and group II ( MTA ) . The treated teeth were evaluated clinical ly and radiographically and were followed-up for 12 months . RESULTS At the end of the 12 months follow-up , the clinical success rates for FC and MTA were 81 % and 100 % , respectively . There was a statistically significant difference ( P = 0.04 ) between the clinical success rates of FC and MTA . While the radiographic success rates for FC and MTA were 81 % and 96 % , respectively , there was no statistically significant difference between the radiographic success of MTA and FC . CONCLUSION White MTA showed a higher clinical and radiographic success rate when compared to FC as a pulpotomy agent in vital primary molars , and it has a potential to become a replacement for FC in primary molars Aim To compare the clinical and radiographic success rates of three different pulpotomy agents in primary molars after 18 months . Methods The study was carried out with 51 primary molars of children aged 5–9 years old . The teeth were r and omly assigned to the experimental or control groups . After coronal pulp removal and haemostasis , the remaining pulp tissue was covered with Biodentine ® or mineral trioxide aggregate in the experimental groups . In the control group , formocresol was placed with a cotton pellet over the pulp tissue for 5 min and after removal the pulp tissue was covered with zinc oxide – eugenol ( ZOE ) paste . All teeth were immediately restored with reinforced ZOE base and resin modified glass-ionomer cement , and later with pre-formed metal crowns . Follow-up assessment s were carried out after 3 , 6 , 12 and 18 months . Results Forty-five teeth were available for follow up at the end of 18 months . All of the available teeth for mineral trioxide aggregate and Biodentine ® were clinical ly successful , as were 73.3 % of the FC group . Radiographic success rate for the formocresol group at 18 months follow up was 73.3 , 100 % for mineral trioxide aggregate and 86.6 % for Biodentine ® group . Conclusion Mineral Trioxide aggregate and Biodentine ® showed more favourable results than formocresol PURPOSE The aim of this study was to compare the effect of mineral trioxide aggregate ( MTA ) to that of formocresol ( FC ) as pulp dressing agents in pulpotomized primary molars with carious pulp exposure . METHODS Forty-five primary molars of 26 children were treated by a conventional pulpotomy technique . The teeth were r and omly assigned to the MTA ( experimental ) or FC ( control ) group by a toss of a coin . Following removal of the coronal pulp and hemostasis the pulp stumps were covered with an MTA paste in the experimental group . In the control group , FC was placed with a cotton pellet over the pulp stumps for 5 minutes and removed ; the pulp stumps were then covered by zinc oxide-eugenol ( ZOE ) paste . The teeth of both groups were restored with stainless steel crowns . Eighteen children with 32 teeth arrived for clinical and radiographic follow-up evaluation ranging from 6 to 30 months . RESULTS The follow-up evaluations revealed only one failure ( internal resorption detected at a 17 months postoperative evaluation ) in a molar treated with formocresol . None of the MTA-treated teeth showed any clinical or radiographic pathology . Pulp canal obliteration was observed in 9 of 32 ( 28 % ) evaluated molars . This finding was detected in 2 out of the 15 teeth treated with FC ( 13 % ) and in 7 out of the 17 treated with MTA ( 41 % ) . CONCLUSION MTA showed clinical and radiographic success as a dressing material following pulpotomy in primary teeth and seems to be a suitable replacement for formocresol in primary teeth OBJECTIVE To compare clinical and radiographic outcomes of pulpotomy treatment using calcium-enriched mixture ( CEM ) cement and mineral trioxide aggregate ( MTA ) in carious-exposed vital immature permanent first molars . DESIGN Fifty-one immature molars with clinical carious exposure with symptomatic/asymptomatic pulpitis met the inclusion criteria and r and omly assigned to one of the treatment groups ( CEM [ 26 teeth ; 59 roots ] , MTA [ 25 teeth ; 59 roots ] ) . After performing pulpotomy and covering the radicular pulps with the bio material s , all teeth were permanently restored . Blinded clinical and radiographic evaluations were performed at 6 and 12 months after operation for signs of success or failure . Radiographs were evaluated for complete/partial apical closure . The data were analysed using chi-square test and generalized estimating equation ( GEE ) model . RESULTS There was no significant difference at the baseline between the two experimental groups . All available cases ( 49 teeth ) showed pulp survival and signs of continuous root development after 12 months . Overall , complete apical closure ( apexogenesis ) occurred in 76.8 % and 73.8 % of radiographically interpreted roots in CEM cement and MTA groups , respectively . There was no statistical difference in terms of radiographic outcomes between two groups . CONCLUSIONS Calcium-enriched mixture cement and MTA showed similar performance in pulpotomy of immature caries-exposed permanent molars Introduction : The aim of this quantitative systematic review /meta- analysis was to compare the treatment outcomes of mineral trioxide aggregate ( MTA ) and calcium hydroxide ( CH ) in pulpotomy of human primary molars . The focused PICO question was “ in case of pulp exposure in vital primary molars , how does MTA pulpotomy compare to CH in terms of clinical /radiographic success ? ” Methods and Material s : We retrieved published r and omized clinical trials ( RCTs ) of at least 6-month duration ; our search included articles published up to March 2013 in five following data bases : PubMed ( Medline ) , Cochrane data base of systematic review s , Science Citation Index , EMBASE , and Google Scholar . Mantel Haenszel and Inverse Variance-weighted methods were applied by STATA ; the relative risk ( RR ) was calculated with 95 % confidence intervals ( CI ) . Results : A total of 282 English articles were collected . Two authors independently screened the articles and five RCTs were selected ; data extraction and quality assessment were then carried out . Four RCTs were appropriate for meta- analysis according to their follow-up times by Mantel Haenszel method . Statistically significant difference was found between success rate of MTA compared to CH , with RR=0.08 ( 95 % CI , 0.02 - 0.39 ) , RR=0.19 ( 95 % CI , 0.08 - 0.46 ) , and RR=0.38 ( 95 % CI , 0.21 - 0.68 ) for 6- , 12- , and 24-month follow-ups , respectively . A significant difference was also observed for all included RCTs after analyses using the Inverse Variance-weighted method ( RR=0.44 ; 95 % CI , 0.27 - 0.72 ) . Conclusions : Systematic review /meta- analysis of included RCTs revealed that for pulpotomy of vital primary molars , MTA has better treatment outcomes compared to CH
TSA indicated lack of firm evidence for the results of the meta‐analytic outcomes on clinical and radiographic success .
Conclusion BD and MTA have similar clinical and radiographic success rates based on limited and low‐ quality evidence .
Objectives Pulpotomy is the favored treatment for pulp exposure in carious primary teeth .
This review aim ed to compare the success rates of biodentine ( BD ) and mineral trioxide aggregate ( MTA ) pulpotomies  in primary molars using meta‐ analysis ( MA ) and trial sequential analysis ( TSA ) and also to assess the quality of the results by Grading of Recommendations , Assessment , Development and Evaluation ( GRADE ) .