Effects of a New Flavonoid and Myo-Inositol Supplement on Some Biomarkers of Cardiovascular Risk in Postmenopausal Women: A Randomized Trial Epidemiologic Evidence on Serum Adiponectin Level and Lipid Profile Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial Fish oil supplementation in patients with heterozygous familial hypercholesterolemia. Psyllium Supplementation in Adolescents Improves Fat Distribution & Lipid Profile: A Randomized, Participant-Blinded, Placebo-Controlled, Crossover Trial Myo-inositol, D-chiro-inositol, folic acid and manganese in second trimester of pregnancy: a preliminary investigation. Inositol supplementation in premature infants with respiratory distress syndrome. A comparative study of the effect of green tea and sour tea on blood pressure and lipid profile in healthy adult men
Background and Aim . Cardiovascular risk is increased in women with menopause and metabolic syndrome . Aim of this study was to test the effect of a new supplement formula , combining cocoa polyphenols , myo-inositol , and soy isoflavones , on some biomarkers of cardiovascular risk in postmenopausal women with metabolic syndrome . Methods and Results . A total of 60 women were enrolled and r and omly assigned ( n = 30 per group ) to receive the supplement ( NRT : 30 mg of cocoa polyphenols , 80 mg of soy isoflavones , and 2 gr of myo-inositol ) , or placebo for 6 months . The study protocol included three visits ( baseline , 6 , and 12 months ) for the evaluation of glucose , triglycerides , and HDL-cholesterol ( HDL-C ) , adiponectin , visfatin , resistin , and bone-specific alkaline phosphatase ( bone-ALP ) . At 6 months , a significant difference between NRT and placebo was found for glucose ( 96 ± 7 versus 108 ± 10 mg/dL ) , triglycerides ( 145 ± 14 versus 165 ± 18 mg/dL ) , visfatin ( 2.8 ± 0.8 versus 3.7 ± 1.1 ng/mL ) , resistin ( 27 ± 7 versus 32 ± 8 µg/L ) , and b-ALP ( 19 ± 7 versus 15 ± 5 µg/mL ) . No difference in HDL-C concentrations nor in adiponectin levels between groups was reported at 6 months . Conclusions . The supplement used in this study improves most of the biomarkers linked to metabolic syndrome . This Trial is registered with NCT01400724 The concentration of adiponectin , a hormone which is secreted from adipose tissue , is inversely correlated with body fat mass . This hormone has anti inflammatory and anti atherogenic properties . Its concentration reduces in metabolic syndrome and cardiovascular diseases . This study review s the evidence on the relationship between serum  adiponectin concentration and lipid profile .  In this study former clinical trials , cross sectional and prospect i ve studies have been review ed . The PubMed search engine has been used to find related research for the topic by considering dyslipidemia , total cholesterol ( TC ) , high and low density protein ( HDL and LDL ) , triglyceride ( TG ) , lipid profile ( LP ) and adiponectin as the key words . Finally , 25 articles were recruited to review in the present article . Serum adiponectin level was positively correlated with plasma HDL cholestrol concentrations . There was a significant inverse relationship between plasma triglyceride and serum adiponectin . An inverse correlation between very low density lipoprotein ( VLDL ) and LDL levels and adiponectin was reported from the studies . So , Adiponectin has an important role in the metabolism of lipid profile including HDLc Background : Nonalcoholic fatty liver disease ( NAFLD ) is one of the most common hepatic diseases in the general adult population . Dyslipidemia , hyperuricemia , and insulin resistance are common risk factors and accompanying features of NAFLD . Curcumin is a dietary natural product with beneficial metabolic effects relevant to the treatment of NAFLD . Aim : To assess the effects of curcumin on metabolic profile in subjects with NAFLD . Methods : Patients diagnosed with NAFLD ( grade s 1–3 ; according to liver sonography ) were r and omly assigned to curcumin ( 1000 mg/d in 2 divided doses ) ( n = 50 ) or control ( n = 52 ) group for a period of 8 weeks . All patients received dietary and lifestyle advises before the start of trial . Anthropometric measurements , lipid profile , glucose , insulin , glycated hemoglobin , and uric acid concentrations were measured at baseline and after 8 weeks of follow-up . Results : Eighty-seven subjects ( n = 44 and 43 in the curcumin and control group , respectively ) completed the trial . Supplementation with curcumin was associated with a reduction in serum levels of total cholesterol ( P < 0.001 ) , low-density lipoprotein cholesterol ( P < 0.001 ) , triglycerides ( P < 0.001 ) , non – high-density lipoprotein cholesterol ( P < 0.001 ) , and uric acid ( P < 0.001 ) , whereas serum levels of high-density lipoprotein cholesterol and glucose control parameters remained unaltered . Curcumin was safe and well tolerated during this study . Conclusion : Results of the present trial suggest that curcumin supplementation reduces serum lipids and uric acid concentrations in patients with NAFLD Familial hypercholesterolemia is associated with premature coronary heart disease . In patients with familial hypercholesterolemia , monotherapy with hydroxymethylglutaril coenzyme . A reductase inhibitors rarely achieves the goal of desirable low-density lipoprotein levels . Epidemiological studies suggest that population s with a high dietary intake of marine n3 fatty acids are protected against coronary heart disease . Hepatic synthesis and secretion of very low density lipoproteins are reduced during fish oil supplementation while other effects on lipid and lipoprotein metabolism are controversial . Fourteen patients affected by familial heterozygous hypercholesterolemia on chronic treatment with simvastatin  were enrolled in a double blind , placebo controlled , r and omized crossover trial that evaluated the effect of fish oil ethyl ester ( Esapent , 5.1 g/day ) on lipid and lipoprotein serum concentrations . Total cholesterol , low density lipoprotein cholesterol , high density lipoprotein cholesterol , triglycerides , apoprotein B , apoprotein AI , lipoprotein ( a ) did not show any significant variation during the four week treatment period with fish oil ethyl ester . The present data suggest that the possible favourable influence of fish oil on the progression of atherosclerosis in these high-risk patients might involve mechanisms which are different from lipid metabolism Aims We aim ed to assess the effects of psyllium supplementation on insulin sensitivity and other parameters of the metabolic syndrome in an at risk adolescent population . Methods This study encompassed a participant-blinded , r and omized , placebo-controlled , crossover trial . Subjects were 47 healthy adolescent males aged 15–16 years , recruited from secondary schools in lower socio-economic areas with high rates of obesity . Participants received 6 g/day of psyllium or placebo for 6 weeks , with a two-week washout before crossing over . Fasting lipid profiles , ambulatory blood pressure , auxological data , body composition , activity levels , and three-day food records were collected at baseline and after each 6-week intervention . Insulin sensitivity was measured by the Matsuda method using glucose and insulin values from an oral glucose tolerance test . Results 45 subjects completed the study , and compliance was very high : 87 % of participants took > 80 % of prescribed capsules . At baseline , 44 % of subjects were overweight or obese . 28 % had decreased insulin sensitivity , but none had impaired glucose tolerance . Fibre supplementation led to a 4 % reduction in and roid fat to gynoid fat ratio ( p = 0.019 ) , as well as a 0.12 mmol/l ( 6 % ) reduction in LDL cholesterol ( p = 0.042 ) . No associated adverse events were recorded . Conclusions Dietary supplementation with 6 g/day of psyllium over 6 weeks improves fat distribution and lipid profile ( parameters of the metabolic syndrome ) in an at risk population of adolescent males . Trial Registration Australian New Zeal and Clinical Trials Registry DESIGN AND PURPOSE The supplemental administration of myo-inositol , D-chiro-inositol , folic acid and manganese ( MDFM ) was tested in a prospect i ve , r and omized , double-blind , placebo controlled clinical trial , pilot study , to test the hypothesis that its supplemental administration in the second trimester of pregnancy would improve glucose and glycemic parameters and blood pressure . SUBJECTS AND METHODS Non-obese uniparous healthy pregnant women between 13th and 24th week of pregnancy were divided into two groups : group I , control group with placebo , and the group II , women in treatment with myo-inositol , D-chiro-inositol , folic acid and manganese . The main outcome measures were the comparative analysis of the parameters analyzed at time 0 , after 30 days and 60 days ; secondary outcome measure was the overall analysis of investigated parameters . RESULTS 24 women were allocated to receive MDFM and 24 the placebo . The two groups did not significantly differ for demographic , lipidic and glycemic parameter and blood pressure . After 30 days , significantly lower cholesterol ( p = 0.0001 ) , significantly lower LDL ( p = 0.0013 ) , lower TG ( p < 0.0001 ) and lower glycemia ( p = 0.0021 ) were observed all favoring group II . No significant difference was observed for HDL , diastolic and systolic blood pressure . After 60 days , significant difference was observed for cholesterol ( p = 0.0001 ) , LDL ( p = 0.0001 ) , HDL ( p = 0.0001 ) , TG ( p = 0.0001 ) , glycemia ( p = 0.0064 ) , all favoring the group treated with MDFM . No significant differences were observed for systolic ( p = 0.12 ) and diastolic blood pressure ( p = 0.42 ) . When examining for overall differences between the two groups , a significant difference was observed for examined parameters at time 0 and at time 60 ; cholesterol ( p = 0.0001 ) , LDL ( p = 0.0001 ) , HDL ( p = 0.047 ) , TG ( p = 0.0001 ) and glycemia ( p = 0.019 ) were reduced in the MDFM group . A significant reduction was also observed in group II for systolic blood pressure after 60 days of intervention ( p = 0.0092 ) , but not for diastolic blood pressure ( p = 0.29 ) . CONCLUSIONS MDFM administration after 30 days in pregnancy improved glycemic and lipidic parameters , with significant gain after 60 days , without affecting diastolic blood pressure levels BACKGROUND Inositol influences cellular function and organ maturation . Feeding premature infants inositol-rich breast milk increases their serum inositol concentrations . Whether inositol supplementation benefits infants receiving fluids for parenteral nutrition , which are inositol-free , is not known . METHODS We carried out a placebo-controlled , r and omized , double-blind trial to determine the effects of administering inositol ( 80 mg per kilogram of body weight per day ) during the first five days of life to 221 infants with respiratory distress syndrome who were receiving parenteral nutrition ( gestational age , 24 to 32 weeks ; birth weight , less than 2000 g ) . All the infants were treated with mechanical ventilation and some with surfactant as well . The primary end point was survival at 28 days without bronchopulmonary dysplasia . RESULTS The 114 patients given inositol  had significantly lower mean requirements for inspiratory oxygen ( P less than 0.01 ) and mean airway pressure ( P less than 0.05 ) from the 12th through the 144th hour of life than did the 107 infants given placebo . Eighty-one infants given inositol and 51 given placebo  survived without bronchopulmonary dysplasia ( 71 vs. 55 percent ; P = 0.005 ) . In the 65 infants given surfactant , however , inositol had no effect on the degree of respiratory failure .  Thirteen infants given  inositol and 21 given placebo had retinopathy of prematurity ( 13 vs. 26 percent ; P = 0.022 ) ; none of the infants given inositol had stage 4 disease , whereas 7 of those given placebo did ( 0 vs. 9 percent ; P = 0.012 ) . Among the infants given placebo , those who had poor outcomes ( death , bronchopulmonary dysplasia , or stage 4 retinopathy of prematurity ) had lower serum inositol concentrations during days 2 through 7 than those who had good outcomes ( P less than 0.01 ) . CONCLUSIONS The administration of inositol to premature infants with respiratory distress syndrome who are receiving parenteral nutrition during the first week of life is associated with increased survival without bronchopulmonary dysplasia and with a decreased incidence of retinopathy of prematurity BACKGROUND Cardiovascular diseases ( CVD ) are a set of metabolic disorders affecting heart and blood vessels . Green tea and sour tea ( Hibiscus sabdariffa L. ) have attracted significant attention recently due to their high popularity , nutrient profile and therapeutic effects . The aim of the present study was to compare the effects of green tea and sour tea supplementation on blood pressure and lipid profile in healthy adult men . METHODS This r and omized , double-blind , placebo-controlled trial included 54 healthy adult men . The participants were r and omly assigned to two intervention groups receiving 450 mg green tea or sour tea and one placebo group which consumed 450 mg placebo ( maltodextrin ) for 6 weeks . Blood pressure , lipid profile , dietary intake and physical activity were measured pre- and post-intervention and compared . RESULTS After 6 weeks of intervention , sour tea supplementation led to a significant decrease in systolic blood pressure ( SBP ) compared with the placebo group . However , we faild to find any significant difference in SBP between green tea and control groups . Also , no significant changes were observed in diastolic blood pressure ( DBP ) and lipid profile between the three groups . In comparison with baseline , there was a significant increase in the mean level of serum high-density lipoprotein cholesterol ( HDL-C ) in green tea and sour tea groups . Also , the interventions result ed in significant decrease in the mean levels of serum total cholesterol ( TC ) and low-density lipoprotein cholesterol ( LDL-C ) and DBP in the sour tea group compared with the pre-intervention value . CONCLUSION On the basis of our findings , sour tea supplementation led to decreased SBP  in healthy men compared with the placebo , but there was no significant difference between their effects on DBP and lipid profile
Conclusions Inositol supplementation may result in reduction in triglycerides , total- and LDL-cholesterol levels , but did not affect HDL-cholesterol levels  among patients with metabolic diseases .
Background Several studies have evaluated the effect of inositol supplementation on lipid profiles among population with metabolic diseases ; however , the findings are controversial .
This review of r and omized controlled trials ( RCTs ) was performed to summarize the evidence of the effects of inositol supplementation on lipid profiles among population with metabolic diseases .