The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women. Effects of Chinese Green Tea on Weight, and Hormonal and Biochemical Profiles in Obese Patients With Polycystic Ovary Syndrome—A Randomized Placebo-Controlled Trial Laparoscopic ovarian drilling in the treatment of polycystic ovary syndrome: how many punctures per ovary are needed to improve the reproductive outcome?
Background To our knowledge , no reports are available indicating the effects of synbiotic supplementation on hormonal status , biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome ( PCOS ) . This research was done to assess the effects of synbiotic supplementation on hormonal status , biomarkers of inflammation and oxidative stress in subjects with PCOS . Methods This r and omized double-blind , placebo-controlled trial was conducted on 60 subjects diagnosed with PCOS according to the Rotterdam criteria . Subjects were r and omly assigned into two groups to take either synbiotic ( n = 30 ) or placebo ( n = 30 ) for 12 weeks . Endocrine , inflammation and oxidative stress biomarkers were quantified at baseline and after the 12-week intervention . Results After the 12-week intervention , compared with the placebo , synbiotic supplementation significantly increased serum sex hormone-binding globulin ( SHBG ) ( changes from baseline in synbiotic group : + 19.8 ± 47.3 vs. in placebo group : + 0.5 ± 5.4 nmol/L , p = 0.01 ) , plasma nitric oxide ( NO ) ( changes from baseline in synbiotic group : + 5.5 ± 4.8 vs. in placebo group : + 0.3 ± 9.1 μmol/L , p = 0.006 ) , and decreased modified Ferriman Gallwey ( mF-G ) scores ( changes from baseline in synbiotic group : − 1.3 ± 2.5 vs. in placebo group : − 0.1 ± 0.5 , p = 0.01 ) and serum high-sensitivity C-reactive protein ( hs-CRP ) ( changes from baseline in synbiotic group : − 950.0 ± 2246.6 vs. in placebo group : + 335.3 ± 2466.9 ng/mL , p = 0.02 ) . We did not observe any significant effect of synbiotic supplementation on other hormonal status and biomarkers of oxidative stress . Conclusions Overall , synbiotic supplementation for 12 weeks in PCOS women had beneficial effects on SHBG , mFG scores , hs-CRP and NO levels , but did not affect other hormonal status and biomarkers of oxidative stress . Trial registration This study was retrospectively registered in the Iranian website ( www.i rct .ir ) for registration of clinical trials ( I RCT 201509115623N53 ) , on 2015–09 - 27 We prospect ively estimated the prevalence of the polycystic ovary syndrome ( PCOS ) , as defined by the NIH/NICHHD 1990 endocrine criteria , in a population of 154 Caucasian women of reproductive age reporting spontaneously for blood donation .  Anthropometric data ; the presence of hirsutism , acne , and and rogenic alopecia ; and the menstrual history were recorded by a single investigator . In 145 women , blood sample s were also obtained for measurement of serum and rogen levels .  PCOS was defined by the presence of 1 ) oligomenorrhea , 2 ) clinical and /or biochemical hyper and rogenism , and 3 ) exclusion of hyperprolactinemia , thyroid disorders , and nonclassic 21-hydroxylase deficiency . Hirsutism was defined by a modified Ferriman-Gallwey score of 8 or more , acne was considered as a sign of hyper and rogenism when persistent after the second decade of life , and hyper and rogenemia was defined by an increase in circulating testosterone or dehydroepi and rosterone sulfate or an increase in the free and rogen index above the 95th percentile of the control values derived from the nonhirsute , nonacneic women having regular menses who were not receiving hormonal therapy . PCOS was present in 10(6.5 % ) , hirsutism was present in 11 ( 7.1 % ) , and acne was present in 19 ( 12.3 % ) of the 154 women . Our results demonstrate a 6.5 % prevalence of PCOS , as defined , in a minimally biased population of Caucasian women from Spain . The polycystic ovary syndrome , hirsutism , and acne are common endocrine disorders in women BACKGROUND Surprisingly , the prevalence of polycystic ovary syndrome ( PCOS ) in otherwise unselected overweight or obese women is unknown , despite obesity being frequent in patients with PCOS . We conducted the present study to obtain an unbiased estimate of the prevalence of PCOS in unselected overweight and obese premenopausal women from Spain . METHODS All premenopausal women reporting to the Department of Endocrinology , Hospital Universitario Ramón y Cajal , for dietary treatment of overweight or obesity from May 2002 to December 2005 were prospect ively recruited . Women referred for any other reason were automatically excluded to avoid selection bias . Diagnosis of PCOS relied on the presence of clinical and /or biochemical hyper and rogenism , oligo-ovulation , and exclusion of secondary causes . Anthropometric measurements , hirsutism scores , and and rogen , gonadotropin , metabolic , and lipid profiles were obtained . RESULTS Of a total of 113 consecutive women recruited , 32 ( 28.3 % ) were diagnosed as having PCOS ( 95 % confidence interval , 20.0%-36.6 % ) . The prevalence of PCOS was not different when considering the degree of obesity . Another 3 women presented with hyper and rogenemia without oligo-ovulation , 2 had idiopathic hirsutism , 2 had chronic oligomenorrhea without clinical or biochemical hyper and rogenism , and 2 had oligomenorrhea with hyperprolactinemia , precluding the diagnosis of PCOS . The remaining 72 women ( 63.7 % ) had no evidence of hyper and rogenism or reproductive abnormalities . CONCLUSIONS Our results demonstrate a 28.3 % prevalence of PCOS in overweight and obese women from Spain , which is markedly increased compared with the 5.5 % prevalence of PCOS in lean women of our country . Therefore , PCOS must be routinely ruled out in overweight and obese premenopausal women seeking advice for weight loss Objectives : To study the effects of green tea on body weight , and biochemical and hormonal profiles in obese Chinese women with polycystic ovary syndrome ( PCOS ) . Methods : Thirty-four obese Chinese women with PCOS were r and omized into either treatment with green tea capsules or placebo for 3 months . The anthropomentric measurements , and biochemical and hormonal profiles before and after treatment in each group were compared . Results : The body weight of the green tea group decreased by a nonsignificant 2.4 % after treatment ; whereas the body weight , body mass index ( BMI ) , and body fat content of the control group were significantly higher after 3 months . There were no differences in any of the hormone levels measured in either group . The biochemical profiles of the two groups were also similar except that there was a small but significant rise in the triglyceride level in the green tea group . Fewer patients in the green tea group remained amenorrhoeic , but this was not significantly different from the control group . Conclusions : Green tea supplementation did not significantly reduce body weight in obese women with PCOS , nor did it alter the glucose or lipid metabolism AIM To evaluate the biochemical , clinical and reproductive results after laparoscopic ovarian drilling that carried out a different number of punctures in the ovaries . METHODS Sixty-three clomiphene-citrate-resistant women with polycystic ovary syndrome ( PCOS ) underwent laparoscopic ovarian drilling using insulated needle cautery . Patients were allocated to two groups : group I ( n = 26 ) had five punctures per ovary , and group II ( n = 37 ) had 10 punctures per ovary .  Biochemical and clinical data , before and after the procedure along with the reproductive outcome , were compared between the two groups . RESULTS There were no significant differences in terms of body mass index , and insulin and glucose levels before and after the procedure between the two groups . And rogen levels and luteinizing hormone concentrations showed a statistically significant decrease after the treatment . The clinical and reproductive outcome , including menses cyclicity , ovulation , and pregnancy rates were similar in both groups . CONCLUSION Laparoscopic ovarian drilling is an effective treatment in clomiphene-citrate-resistant women with PCOS . Five , instead of > or = 10 , punctures per ovary are sufficient to ameliorate the hyper and rogenic status in these women , improving their clinical and reproductive outcome
The findings suggest that pro-/synbiotic supplementation may improve glucose homeostasis parameters , hormonal , and inflammatory indices in women with PCOS
This study aim ed to systematic ally review r and omized clinical trials ( RCTs ) to clarify the effects of pro-/synbiotic supplementation on anthropometric and biochemical measurements in women with polycystic ovary syndrome ( PCOS ) .