Effects of palm olein and olive oil on serum lipids in a Chinese population: a randomized, double-blind, cross-over trial. [Changes in of plasma lipoproteins after the use of palm oil in the diet of a group healthy adults]. The type of oil used for cooking is associated with the risk of nonfatal acute myocardial infarction in costa rica. Replacement of partially hydrogenated soybean oil by palm oil in margarine without unfavorable effects on serum lipoproteins Comparison of the effects of supplemental red palm oil and sunflower oil on maternal vitamin A status. Replacement of dietary fat with palm oil: effect on human serum lipids, lipoproteins and apolipoproteins. Palm olein increases plasma cholesterol moderately compared with olive oil in healthy individuals. Behenic acid is a cholesterol-raising saturated fatty acid in humans. Fat high in stearic acid favorably affects blood lipids and factor VII coagulant activity in comparison with fats high in palmitic acid or high in myristic and lauric acids. The effect of red palm olein and refined palm olein on lipids and haemostatic factors in hyperfibrinogenaemic subjects. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Effects of Partially Hydrogenated, Semi-Saturated, and High Oleate Vegetable Oils on Inflammatory Markers and Lipids Effects of red palm oil on serum lipids and plasma carotenoids level in Chinese male adults. Palm oil and cardiovascular disease: a randomized trial of the effects of hybrid palm oil supplementation on human plasma lipid patterns. Virgin olive oil, palm olein and coconut oil diets do not raise cell adhesion molecules and thrombogenicity indices in healthy Malaysian adults Small Dense Low-Density Lipoprotein Concentration and Oxidative Susceptibility Changes after Consumption of Soybean Oil, Rice Bran Oil, Palm Oil and Mixed Rice Bran/Palm Oil in Hypercholesterolaemic Women Independence of the effects of cholesterol and degree of saturation of the fat in the diet on serum cholesterol in man. Fatty acid saturation of the diet and plasma lipid concentrations, lipoprotein particle concentrations, and cholesterol efflux capacity. Effect on plasma lipids of interesterifying a mix of edible oils. Comparison of palmolein and olive oil: effects on plasma lipids and vitamin E in young adults. Accelerated atherosclerosis in apolipoprotein E-deficient mice fed Western diets containing palm oil compared with extra virgin olive oils: a role for small, dense high-density lipoproteins.
BACKGROUND AND OBJECTIVES As the most widely produced edible vegetable oil , palm oil is known as to contain a high level of saturated fatty acid , which was thought to adversely affect serum lipid profiles . However , recent studies have shown no influence or benefits of palm oil on serum lipids . The potential nutritional value of palm oil is attributed to the high mono-unsaturation at the crucial sn2-position of the oil 's triacylglycerols , as with the so-called ' healthy ' olive oil ( OO ) . The aim of this study was to further test this hypothesis and evaluate the effects of consuming palm olein versus olive oil on serum lipid profiles in a Chinese population . METHODS AND STUDY DESIGN In total , 120 participants were recruited from a spinnery in Yixing city and r and omly divided into two groups ( palm olein or olive oil ) to conduct a 2 × 2 crossover trial for 2 months ' intervention with 2-week washout periods . Each participant was provided 48 g of test oil per day . At the end of each period , anthropometry , and blood lipid indices were measured to determine the effects of palm olein and olive oil . RESULTS Palm olein and olive oil consumption had no significantly different effect on BMI , on serum total cholesterol , low-density lipoprotein cholesterol , high-density lipoprotein cholesterol , triacylglycerol ( TG ) , Apo B , fasting glucose , or insulin concentrations ( all p>0.05 ) . CONCLUSIONS In a dietary crossover trial , palm olein and olive oil had no recognisably different effects on body fatness or blood lipids in a healthy Chinese population UNLABELLED Although saturated fat acids have long known to have harmful effects on cholesterol and triacylglycerides levels in blood , new concepts have emerged form recent research on this matter . The purpose of this study was to know the effect of the consumption of palm olein on triacylglycerides and cholesterol levels as well as lipoprotein fractions in the blood plasma of healthy individuals from both sexes . MATERIAL S AND METHODS Different types of fats were administered for 12 weeks to 60 subjects , 45 male , 15 female , between 19 and 45 years of age , who were divided into three groups : the mix group ( MG ) was administered oil , margarine , and mayonnaise prepared with 50 % olein ; the olein group ( OG ) consumed fats prepared with 100 % olein ; and the control group ( CG ) consumed regular fats of customary use by the population . The diets provided 25 to 30 % of calories . Blood sample s were obtained for lipid analysis at the beginning and the end of the study . Plasma triacylglycerides and cholesterol concentrations were determined by means of enzyme and lipoprotein methods ( VLDL , LDL ; and HDL ) by ultracentrifugation . RESULTS AND DISCUSSION By comparing the groups ' means no significant differences were found ( p > 0.05 ) in blood lipids . Individual differences show a slight increase in VLDL-C in OG compared to MG and CG . No differences were found in LDL concentration . CONCLUSIONS These results contribute evidence to differentiate between the effects of saturated vegetables oils , such as coconut oil , and of palm olein . The authors recommend not extrapolate the effects of type of oil to another in connection with TC increase in blood Palm oil and soybean oil are the 2 most widely used cooking oils in the world . Palm oil is consumed mainly in developing countries , where morbidity and mortality due to cardiovascular disease ( CVD ) are on the rise . Although cl aims about adverse or protective effects of these oils are commonly made , there are no epidemiologic studies assessing the association between these oils and cardiovascular disease endpoints . We examined whether consumption of palm oil relative to soybean oil and other unsaturated oils ( predominantly sunflower ) is associated with  myocardial infa rct ion ( MI ) in Costa Rica . The cases ( n = 2111 ) were survivors of a first acute MI and were matched to r and omly selected population controls ( n = 2111 ) .  Dietary intake was assessed with a vali date d semiquantitative FFQ . Adipose tissue profiles of essential fatty acids were assessed to vali date cooking oil intake and found to be consistent with self-reported major oils used for cooking . The data were analyzed using conditional logistic regression . Palm oil users were more likely to have an MI than users of soybean oil [ odds ratio ( OR ) = 1.33 ; 95 % CI : 1.08 - 1.63 ] or other cooking oils ( OR = 1.23 ; CI : 0.99 - 1.52 ) , but they did not differ from users of soybean oil with a high trans-fatty acid content ( OR = 1.14 ; CI : 0.84 - 1.56 ) . These data suggest that as currently used in Costa Rica , and most likely in many other developing countries , the replacement of palm oil with a polyunsaturated nonhydrogenated vegetable oil would reduce the risk of MI We have compared the effects of three different margarines , one based on palm oil ( PALM-margarine ) , one based on partially hydrogenated soybean oil ( TRANS-margarine ) and one with a high content of polyunsaturated fatty acids ( PUFA-margarine ) , on serum lipids in 27 young women . The main purpose of the study was to test if replacement of trans fatty acids in margarine by palmitic acid results in unfavorable effects on serum lipids . The sum of saturated fatty acids ( 12∶0 , 14∶0 , 16∶0 ) was 36.3 % of total fatty acids in the PALM-diet , the same as the sum of saturated ( 12∶0 , 14∶0 , 16∶0 ) ( 12.5 % ) and trans ( 23.1 % ) fatty acids in the TRANS-diet . This sum was 20.7 % in the PUFA-diet . The content of oleic acid was 37.9 , 35.2 , and 38.6 % , respectively , in the three diets , whereas linoleic acid amounted to 16 , 13.5 , and 27.3 % , respectively . Total fat provided 30–31 % and the test margarines 26 % of total energy in all three diets . The subjects consumed each of the diets for 17 d in a Latin-square crossover design . There were no significant differences in total cholesterol , low density lipoprotein (LDL)-cholesterol and apolipoprotein B ( apoB ) between the TRANS- and the PALM-diets . High density lipoprotein (HDL)-cholesterol and apoA-I were significantly higher on the PALM-diet compared to the TRANS-diet whereas the ratio of LDL-cholesterol to HDL-cholesterol was lower , although not significantly ( P=0.077 ) on the PALM-diet . Total cholesterol , LDL-cholesterol , and apoB were significantly lower on the PUFA-diet compared to the two other diets . HDL-cholesterol was not different on the PALM- and the PUFA-diets but it was significantly lower on the TRANS-diet compared to the PUFA diet . Compared to the PUFA-diet  the ratio of LDL-to HDL-cholesterol was higher on both the PALM- and the TRANS-diets whereas apoA-I was not different . Triglycerides and lipoprotein ( a ) were not significantly different among the three diets . We concluded that nutritionally , palmitic acid from palm oil may be a reasonable alternative to trans fatty acids from partially hydrogenated soybean oil in margarine if the aim is to avoid trans fatty acids . A palm oil-based margarine is , however , less favorable than one based on a more polyunsaturated vegetable oil BACKGROUND Conflicting results have been reported on the ability of dietary carotenoids to improve vitamin A status in lactating women .  Red palm oil is one of the richest dietary sources of beta-carotene . OBJECTIVE We aim ed to determine the efficacy of red palm oil in increasing retinol and provitamin A status in pregnant and lactating women . DESIGN Ninety rural , pregnant Tanzanian women from 3 r and omly selected villages were recruited during their third trimester to participate in 3 dietary intervention groups : a control group , who were encouraged to maintain the traditional practice of eating staples with dark-green leafy vegetables , and 2 study groups , who were given either sunflower or red palm oil for use in household food preparations . The intervention lasted 6 mo . Plasma sample s were collected at the third trimester and 1 and 3 mo postpartum , and breast-milk sample s were collected 1 and 3 mo postpartum . RESULTS Supplementation with red palm oil , which is rich in provitamin A , increased alpha- and beta-carotene concentrations significantly ( P < 0.001 ) in both plasma and breast milk . Plasma retinol concentrations were similar in all dietary groups . Breast-milk retinol concentrations tended to decrease from 1 to 3 mo postpartum in the control group , but were maintained in both oil groups . The difference in change in breast-milk retinol concentration between the red palm oil group and the control group was significant ( P = 0.041 ) . CONCLUSIONS Consumption of red palm oil increases concentrations of alpha- and beta-carotene in both breast milk and serum and maintains breast-milk retinol concentrations . Sunflower oil consumption seems to conserve breast-milk retinol similarly to consumption of red palm oil . Breast-milk retinol might be maintained through increased dietary intake of these vegetable oils and use of mild cooking preparation methods ( such as the addition of oil at the end of cooking and avoidance of frying ) Thirty-eight male volunteers participated in a double-blind cross-over trial evaluating the effect of replacing the usual sources of saturated fat in the Dutch diet ( animal fats and hydrogenated oils ) by palm oil , which is virtually free of cholesterol and trans-fatty acids , on serum lipids , lipoproteins and apolipoproteins . Maximum ( about 70 % ) replacement had no significant effect on serum total cholesterol or most lipoprotein fractions , but result ed in an 11 % increase in serum high-density-lipoprotein (HDL)2-cholesterol relative to the control ( P2 = 0.01 ) . The palm-oil diet also caused an 8 % decrease in low-density-lipoprotein (LDL):HDL2 + HDL3-cholesterol ratio ( P2 = 0.02 ) as well as a 9 % decrease in triacylglycerols in the low-density-lipoprotein fractions ( P2 = 0.01 ) . Palm oil consumption result ed in a 4 % increase in serum apolipoprotein AI ( P2 = 0.008 ) and a 4 % decrease in apolipoprotein B ( P2 = 0.01 ) relative to the control diet ; the B : AI apolipoprotein ratio was decreased by 8 % ( P2 < 0.0001 ) . These results were not significantly affected by the different lipoprotein E phenotypes of the volunteers . Although the observed differences were relatively modest , the present study , nonetheless , indicates that dietary palm oil , when replacing a major part of the normal fat content in a Dutch diet , may slightly reduce the lipoprotein- and apolipoprotein-associated cardiovascular risk profiles BACKGROUND Despite the high content of palmitic acid , palm olein has been shown to have a neutral effect on plasma cholesterol concentrations when compared with olive oil , which is suggested to be attributable to palmitic acid in the sn-1 and sn-3 position . In contrast , palmitic acid is in the sn-2 position in lard . OBJECTIVE The objective was to investigate the effects of a diet rich in palm olein , fractionated palm oil , olive oil , and lard on plasma blood lipids , inflammatory markers , glucose , and insulin . DESIGN A controlled double-blinded , r and omized 3 × 3 wk crossover dietary intervention study included 32 healthy men who daily replaced part of their habitual dietary fat intake with ~ 17 % of energy from palm olein , olive oil , or lard , respectively . RESULTS Compared with intake of olive oil , palm olein and lard  increased total cholesterol and LDL cholesterol ( P < 0.0001 ) . Palm olein result ed in a lower plasma triacylglycerol concentration than did olive oil ( P < 0.01 ) . No difference in effects was observed in plasma HDL-cholesterol , high-sensitivity C-reactive protein , plasminogen activator-1 , insulin , and glucose concentrations . CONCLUSIONS The current study did not support the previous finding that the effect of palm olein on total plasma cholesterol and LDL cholesterol in healthy individuals with normal plasma cholesterol concentrations is neutral compared with that of olive oil . Thus , sn-positioning was not confirmed to be important with regard to the effect on plasma cholesterol . The relatively lower plasma triacylglycerol concentration  after the palm olein diet than after the olive oil diet was unexpected . This trial is registered at clinical trials.gov as NCT00743301 BACKGROUND Dietary behenic acid ( 22:0 ) is poorly absorbed . Because of its low bioavailability compared with other fatty acids and because of its very long chain length , the effect of dietary behenic acid ( behenate ) on serum lipid concentrations in humans is assumed to be neutral . OBJECTIVE The objective was to establish the cholesterol-raising potential of behenic acid by comparing the effects on lipid and lipoprotein concentrations of a specially formulated fat enriched with behenic acid with those of palm oil ( rich in palmitic acid ; 16:0 ) and high-oleic acid sunflower oil ( rich in cis oleic acid ; 18:1 ) . DESIGN In a r and omized , crossover , metabolic-ward study , 7 mildly hypercholesterolemic men were fed 3 natural-food diets supplemented with behenate oil , palm oil , or high-oleic acid sunflower oil .  Mean serum lipid and lipoprotein concentrations and plasma triacylglycerol fatty acid composition were determined from fasting blood drawn during the final 4 d of each 3-wk diet period . RESULTS Behenate oil produced mean concentrations of total cholesterol ( 5.87+/-0.8 mmol/L ) and LDL cholesterol ( 4.40+/-0.8 mmol/L ) not significantly different from those produced by palm oil ( 5.84+/-0.7 and 4.42+/-0.7 mmol/L , respectively ) but significantly higher than those produced by high-oleic acid sunflower oil ( 5.12+/-0.5 and 3.70+/-0.6 mmol/L , respectively ) . There were no significant differences in triacylglycerol or HDL-cholesterol concentrations . CONCLUSIONS Despite its low bioavailability compared with oleic acid , behenic acid is a cholesterol-raising fatty acid in humans and is therefore not a suitable substitute for palmitic acid in manufactured triacylglycerols The effect of fats high in individual , prevalent saturated dietary fatty acids on lipoproteins and hemostatic variables in young healthy subjects was evaluated in a r and omized strictly controlled metabolic feeding study . Three experimental diets : shea butter ( S ; 42 % stearic acid ) , palm oil ( P ; 43 % palmitic palmitic acid ) , and palm-kernel oil with high-oleic sunflower oil ( ML ; 10 % myristic acid , 30 % lauric acid ) were served to 15 men for 3 wk each , separated by washout periods . Diet S compared with diet P result ed in significant reduction in plasma cholesterol ( 22 % ) LDL cholesterol ( 26 % ) , apolipoprotein B ( 18 % ) , HDL cholesterol ( 12 % ) , apolipoprotein A-I ( 13 % ) , and a 13 % lower factor VII coagulant activity ( P = 0.001 ) . Similar differences were observed between diets S and ML . In conclusion , intake of shea butter high in stearic acid favorably affects blood lipids and factor VII coagulant activity in young men , compared with fats high in saturated fatty acids with 12 - 16 carbons Little is known about the physiological effects of red palm olein ( RPO ) . The effects of red palm olein and palm olein ( POL ) compared to sunflower oil ( SFO ) , on lipids , haemostatic factors and fibrin network characteristics in hyperfibrinogenaemic volunteers were investigated . Fifty-nine free-living , hyperfibrinogenaemic volunteers participated in this r and omized , controlled , single blind parallel study . After a 4-week run-in , during which subjects received sunflower oil products , they were paired and r and omly assigned to one of three intervention groups receiving products containing 25 g/day ( approximately 12 % of total energy intake ) of either red palm olein , palm olein or sunflower oil for another 4 weeks . Anthropometric measurements , blood sample s and dietary intakes were measured before run-in , and before and after intervention . The differences in changes in total serum cholesterol response between palm olein and red palm olein ( + 0.59 vs. + 0.18 mmol/l ; p=0.053 ) , and between palm olein and sunflower oil ( + 0.59 vs. -0.003 mmol/l ; p < or = 0.01 ) were significant . The low-density lipoprotein cholesterol ( LDLC ) response in the palm olein- and sunflower oil-groups also differed significantly ( + 0.42 vs. -0.11 mmol/l ; p < or = 0.01 ) . Tissue plasminogen activator antigen ( tPA(ag ) ) decreased significantly in the red palm olein group compared to the palm olein- and sunflower oil-groups . No effects were found in other haemostatic variables .  Palm olein and red palm olein had no independent effect on fibrin network characteristics . In conclusion , compared to palm olein , red palm olein had less detrimental effects on the lipid profile and decreased tissue plasminogen activator antigen . Studies in larger groups are advised for confirmation of results , elucidation of mechanisms and effects of nonglyceride constituents of red palm oil ( PO ) Although medium-chain triacylglycerols ( MCTs , composed of medium-chain fatty acids 8:0 and 10:0 ) have long been described as having neutral effects on serum cholesterol concentrations , experimental evidence supporting this cl aim is limited . In a r and omized , crossover , metabolic-ward study , we compared the lipid effects of a natural food diet supplemented with either MCTs , palm oil , or high oleic acid sunflower oil in nine middle-aged men with mild hypercholesterolemia . Rather than having a neutral effect , MCT oil produced total cholesterol concentrations that were not significantly different from those produced by palm oil ( MCT oil : 5.87 + /- 0.75 mmol/L ; palm oil : 5.79 + /- 0.72 mmol/L ) but significantly higher than that produced by high oleic acid sunflower oil ( 5.22 + /- 0.52 mmol/L ) . Low-density-lipoprotein (LDL)-cholesterol concentrations paralleled those of total cholesterol .  MCT oil tended to result in higher triacylglycerol concentrations than either palm oil or high oleic acid sunflower oil , but this difference was not significant . There were no differences in high-density-lipoprotein cholesterol concentrations . The palmitic acid and total saturated fatty acid content of plasma triacylglycerols in the MCT-oil diet was not significantly different from that in the palm oil diet . On the basis of percentage of energy , this study suggests that medium-chain fatty acids have one-half the potency that palmitic acid has at raising total and LDL-cholesterol concentrations Knowledge about the effects of dietary fats on sub clinical inflammation and cardiovascular disease risk are mainly derived from studies conducted in Western population s. Little information is available on South East Asian countries . This current study investigated the chronic effects on serum inflammatory markers , lipids , and lipoproteins of three vegetable oils . Healthy , normolipidemic subjects ( n = 41 ; 33 females , 8 males ) completed a r and omized , single-blind , crossover study . The subjects consumed high oleic palm olein ( HOPO diet : 15 % of energy 18:1n-9 , 9 % of energy 16:0 ) , partially hydrogenated soybean oil ( PHSO diet : 7 % of energy 18:1n-9 , 10 % of energy 18:1 trans ) and an unhydrogenated palm stearin ( PST diet : 11 % of energy 18:1n-9 , 14 % of energy 16:0 ) . Each dietary period lasted 5 weeks with a 7 days washout period . The PHSO diet significantly increased serum concentrations of high sensitivity C-reactive protein compared to HOPO and PST diets ( by 26 , 23 % , respectively ; P < 0.05 for both ) and significantly decreased interleukin-8 ( IL-8 ) compared to PST diet ( by 12 % ; P < 0.05 ) . In particular PHSO diet , and also PST diet , significantly increased total : HDL cholesterol ratio compared to HOPO diet ( by 23 , 13 % , respectively ; P < 0.05 ) , with the PST diet having a lesser effect than the PHSO diet ( by 8 % ; P < 0.05 ) . The use of vegetable oils in their natural state might be preferred over one that undergoes the process of hydrogenation in modulating blood lipids and inflammation OBJECTIVE Effects of red palm oil on major plasma carotenoids , tocopherol , retinol and serum lipids were evaluated when used in Chinese diet . METHODS Red palm oil group ( RPO ) composed of 20 male subjects(aged 18 - 32 ) and soybean oil group ( SBO ) composed of 22 male subjects ( aged 18 - 32 ) . Dietary fat provided about 28 % of total calories , and the test oil accounted for about 60 % of total dietary fat . In the 3 weeks of pretest period , diets were prepared with soybean oil , and then in the next 6 weeks subjects in each group consumed the diet prepared by test oil . RESULTS Plasma alpha-carotene , beta-carotene and lycopene concentration of RPO group significantly increased at the time of interim ( 21 days ) and of the end ( 42 days ) ( P < 0.05 ) , and alpha-tocopherol concentration significantly increased at the time of the end ( 42 days ) in this study . Though Chinese plasma retinol level was relatively low when compared with that of Westerners , red palm oil diet showed no significant effect on adult Chinese plasma retinol level . Serum concentration of total cholesterol , triglyceride , high density lipoprotein cholesterol , apolipoprotein AI and apolipoprotein B of all subjects showed no significant changes in RPO group during the study . CONCLUSIONS The data in our study suggest that red palm oil is a good source of carotenoids and vitamin E when used in Chinese diet preparation , and it can significantly increase plasma concentration of alpha-carotene , beta-carotene , lycopene and alpha-tocopherol This study examines , for the first time , the effect of  hybrid Elaeis oleifera × E. guineensis palm oil supplementation on human plasma lipids related to CVD risk factors . One hundred sixty eligible participants were r and omized and assigned to one of the two treatments : 25 mL hybrid palm oil ( HPO group ) or 25 mL extra virgin olive oil ( EVOO group ) daily for 3 months . Fasting venous sample s were obtained at baseline and after 1 , 2 and 3 months for measurement of plasma lipids ( TC , LDL-C , HDL-C and TAGs ) . Changes in body mass index and waist circumference were also assessed . Although there was an overall reduction in TC ( 7.4 % , p < 0.001 ) and in LDL-C ( 15.6 % , p < 0.001 ) , no significant differences were found between the treatment groups in a repeated measures analysis of variance for TC ( p = 0.0525 ) , LDL-C ( p = 0.2356 ) , HDL-C ( p = 0.8293 ) or TAGs ( p = 0.3749 ) . Furthermore , HPO consumption had similar effects on plasma lipids to EVOO , thus providing additional support for the concept that hybrid Elaeis oleifera × E. guineensis palm oil can be seen as a " tropical equivalent of olive oil " Background / objectives : Effects of high-protein diets that are rich in saturated fats on cell adhesion molecules , thrombogenicity and other nonlipid markers of atherosclerosis in humans have not been firmly established . We aim to investigate the effects of high-protein Malaysian diets prepared separately with virgin olive oil ( OO ) , palm olein ( PO ) and coconut oil ( CO ) on cell adhesion molecules , lipid inflammatory mediators and thromobogenicity indices in healthy adults . Methods : A r and omized cross-over intervention with three dietary sequences , using virgin OO , PO and CO as test fats , was carried out for 5 weeks on each group consisting of 45 men and women . These test fats were incorporated separately at two-thirds of 30 % fat calories into high-protein Malaysian diets . Results : For fasting and nonfasting blood sample s , no significant differences were observed on the effects of the three test-fat diets on thrombaxane B2 ( TXB2 ) , TXB2/PGF1α ratios and soluble intracellular and vascular cell adhesion molecules . The OO diet induced significantly lower ( P<0.05 ) plasma leukotriene B4 ( LTB4 ) compared with the other two test diets , whereas PGF1α concentrations were significantly higher ( P<0.05 ) at the end of the PO diet compared with the OO diet . Conclusion : Diets rich in saturated fatty acids from either PO or CO and high in monounsaturated oleic acid from virgin OO do not alter the thrombogenicity indices — cellular adhesion molecules , thromboxane B2 ( TXB2 ) and TXB2/prostacyclin ( PGF1α ) ratios . However , the OO diet lowered plasma proinflammatory LTB4 , whereas the PO diet raised the antiaggregatory plasma PGF1α in healthy Malaysian adults . This trial was registered at clinical trials.gov as NCT 00941837 The effects of a diet containing soybean oil ( SBO ) , rice bran oil ( RBO ) , palm oil ( PO ) or a RBO/PO ( 3:1 ) mixture on the composition and oxidation of small dense low-density lipoproteins ( sdLDL ) in 16 hypercholesterolaemic women were investigated . During the 8-week control period , participants consumed a free-choice weight-maintaining diet comprising carbohydrate ( 55 % energy ) , protein ( 15 % energy ) and fat ( 30 % energy ) with < 300 mg/day of cholesterol . During each 10-week study period , participants consumed this same diet but with the addition of one of the three test oils or the RBO/PO mixture .  Total cholesterol and low-density lipoprotein (LDL)-cholesterol levels were significantly reduced during SBO , RBO and RBO/PO consumption , while high-density lipoprotein cholesterol was significantly decreased by SBO consumption . There was a significant reduction in sdLDL-cholesterol levels only after using SBO and it tended to be reduced during RBO/PO consumption , whereas it was significantly increased following PO consumption . The sdLDL oxidation lag time was significantly increased during PO , RBO/PO and RBO consumption , but significantly reduced following SBO . The results for the RBO/PO mixture suggest that this oil mixture might further reduce the risk of atherosclerosis The effect on the fasting serum lipid levels of adding daily 291 mg of cholesterol to diets containing 3 mg of cholesterol and equal fat content , but different fatty acid composition , was tested on 12 young men . The saturated diet provided 97 g/day of a staurated oil made up of 2 parts of palm oil and 1 part of coconut oil . The polyunsatured diet provided 97 g/day of safflower oil . The cholesterol was dissolved in 40 g of either oil incorporated into a spread . A similar spread , devoid of cholesterol , was fed during the cholesterol free periods . Duration of dietary periods was 14 days . Addition of cholesterol produced a mean elevation of serum cholesterol of 9 mg/dl ( SE + /- 2.1 ) in the presence of the saturated diet , and of 8 mg/dl ( SE + /- 1.6 ) in the presence of the polyunsaturated diet . Both cholesterol elevations were significant ( P less than 0.01 ) but not significantly different from each other . Substitution of the saturated diet for the polyunsatured diet caused a significant elevation of serum cholesterol which was the same when the substitution was made in the presence or in the absence of added dietary cholesterol BACKGROUND The fatty acid content and saturation degree of the diet can modulate HDL composition and cholesterol efflux . OBJECTIVE We studied the modifications in plasma lipoprotein particles and serum capacity to stimulate cholesterol efflux induced by different fatty acids . DESIGN Seventeen women and 24 men followed in the same sequence 4 diets containing 35 % of total energy as fat . The saturated fat diet contained 17 % palm oil ; the monounsaturated fat diet , 20.9 % olive oil ; the n-6 polyunsaturated fat diet , 12.5 % sunflower oil ; and the n-3 polyunsaturated fat diet , sunflower oil supplemented with 4 - 4.5 g fish oil/d . Each phase lasted 4 - 5 wk . RESULTS In both sexes , apolipoprotein ( apo ) A-I concentrations were significantly lower with unsaturated fat diets than with the saturated fat diet , but concentrations of lipoproteins containing only apo A-I ( Lp A-I ) were lower only in the men . Concentrations of lipoproteins containing both apo A-I and apo A-II ( Lp A-I : A-II ) were lower with both polyunsaturated fat diets in the women but significantly higher in the men . Lp E concentrations were significantly higher with the 2 polyunsaturated fat diets . Lp E non-B particle concentrations were not modified in the men but were significantly higher in the women in both polyunsaturated fat phases . Lp C-III concentrations were higher with the saturated fat diet only in the men . The serum sample s taken after the n-3 polyunsaturated fat phase were the most efficient for extracting cellular cholesterol in both sexes . CONCLUSIONS The monounsaturated and polyunsaturated fat diets were healthier , producing a better lipid profile . The n-3 polyunsaturated fat diet increased the capacity of serum to promote the efflux of cholesterol from cells in culture The aim was to establish whether interesterification of oils , an alternative to the use of trans fatty acids in margarine manufacture , adversely affects plasma lipids .  Twenty-seven hypercholesterolemic men participated in a double-blind , crossover trial of three margarines : 1 ) high-linoleic acid , moderate trans fatty acids ; 2 ) high-palm oil blend ( predominantly lauric , myristic , palmitic , oleic , and linoleic acids ) ; and 3 ) an interesterified form of the high-palm oil margarine . Both high-palm oil margarines led to similar low-density-lipoprotein ( LDL ) cholesterol concentrations ( 4.43 + /- 0.94 and 4.54 + /- 0.88 mmol/L , respectively ) , which were significantly higher than the LDL concentrations after the high-linoleic acid margarine ( 4.02 + /- 0.85 mmol/L , P < 0.001 ) . Interesterification transferred substantial proportions of palmitic acid into the sn-2 position of glycerides and unsaturated fatty acids into the sn-1,3 positions , and this was reflected in plasma chylomicrons . This study shows that interesterification of oils used to harden margarines does not raise plasma cholesterol more than does the margarine 's constituent fatty acids Twenty-one healthy normocholesterolemic young adults , men and women , completed a r and omized 30-d/30-d crossover comparison of the effect of palmolein and olive oil on plasma lipids . The subjects were free-living volunteers who changed to low-fat diets  to which one of the test oils was added ( used as a spread , for baking , or for frying ) in turn . Complete food records were kept throughout : the test oils were compared at 17 % of total dietary energy . Under the conditions of this experiment plasma total and low-density-lipoprotein ( LDL ) cholesterol were almost identical with the two oils , so that when the palmitic acid ( 16:0 ) in palm oil replaced oleic acid ( 18:1 ) in olive oil the expected increase in LDL cholesterol was not seen . These results indicate that 16:0 , though saturated , is not always a plasma cholesterol-raising fatty acid . Palmolein is rich in vitamin E , alpha-tocopherol , and especially tocotrienols , but the latter were barely detectable in plasma To test the hypothesis that extra virgin olive oils from different cultivars added to Western diets might behave differently than palm oil in the development of atherosclerosis , apoE-deficient mice were fed diets containing different cultivars of olive oil for 10 weeks . Female mice were assigned r and omly to one of the following five groups : ( 1 - 4 ) fed chow diets supplemented with 0.15 % ( w/w ) cholesterol and 20 % ( w/w ) extra virgin olive oil from the Arbequina , Picual , Cornicabra , or Empeltre cultivars , and ( 5 ) fed a chow diet supplemented with 0.15 % cholesterol and 20 % palm oil . Compared to diets containing palm oil , a Western diet supplemented with one of several varieties of extra virgin olive oil decreased atherosclerosis lesions , reduced plaque size , and decreased macrophage recruitment . Unexpectedly , total plasma paraoxonase activity , apoA-I , plasma triglycerides , and cholesterol played minor roles in the regulation of differential aortic lesion development . Extra virgin olive oil induced a cholesterol-poor , apoA-IV-enriched lipoparticle that has enhanced arylesterase and antioxidant activities , which is closely associated with reductions in atherosclerotic lesions . Given the anti-atherogenic properties of extra virgin olive oil evident in animal models fed a Western diet , clinical trials are needed to establish whether these oils are a safe and effective means of treating atherosclerosis
CONCLUSIONS Palm oil consumption results in higher LDL cholesterol than do vegetable oils low in saturated fat and higher HDL cholesterol than do trans fat-containing oils in humans .
The effects of palm oil on blood lipids are as expected on the basis of its high saturated fat content , which supports the reduction in palm oil use by replacement with vegetable oils low in saturated and trans fat .
BACKGROUND Palm oil contains a high amount of saturated fat compared with most other vegetable oils , but studies have reported inconsistent effects of palm oil on blood lipids .
OBJECTIVE We systematic ally review ed the effect of palm oil consumption on blood lipids compared with other cooking oils using data from clinical trials .