[Preventative effect of a whey hydrolyzed formula (Nestle, NAN H.A.) on the development of allergic symptoms in infants]. Formula fortified with live probiotic culture reduces pulmonary and gastrointestinal bacterial colonization and translocation in a newborn animal model.
We examined the prevent effect of a whey hydrolyzed formula ( NAN H.A. ) on the development of  allergic disease from new born infants . A hundred thirty three pregnant women were divided into the  NAN H.A.  group and the  control group . Mothers , who agreed to use the whey hydrolyzed formula to their infant , were classified into the NAN H.A. group . We examined laboratory date such as IgE levels of these infants as well as clinical symptoms for evaluating of the preventive effect of NAN H.A. The serum IgE levels from infants of the NAN H.A. group were lower than those of the control group . The incidance of the infants who showed allergic clinical symptoms was significant lower in the NAN H.A. group . The odds ratio to skin symptom at 3 years of age with multiple logistic regression was 5.32 between the control group and the NAN H.A. group ( p < 0.05 ) . It was 6.68 between mother 's history of allergy was positive and negative ( p < 0.02 ) . These results suggest that NAN H.A. can prevent the development of allergic symptoms in infants BACKGROUND / PURPOSE Acidified diets are protective against intestinal bacterial colonization and translocation .  Probiotic diets are design ed to modulate the intestinal flora to enhance mucosal immunity . This study was design ed to determine if formula acidified with live probiotic decreases bacterial gut colonization and translocation , and is equally tolerated as other acidified diets . METHODS One hundred twenty-eight rabbit pups delivered via cesarean section [ cesarean delivery , cesarean birth , abdominal delivery ] were r and omly assigned to 4 feeding groups :  NAN Nestle ( control , pH 7.0 ) ,  NAN acidified with citric acid ( pH 4.55 ) , biologically acidified Pelargon ( pH 4.55 ) , and  NAN with live Lactococcus lactis culture ( pH 4.2 ) . Pups were gavage fed every 12 hours with Enterobacter cloacae challenges of 10 colony-forming units/mL per feed and killed on day of life 3 . Lungs , liver , spleen , mesenteric lymph nodes ( MLNs ) , stomach , and cecum were cultured and quantitatively analyzed for target organism growth . Results were analyzed using chi(2 ) tests . RESULTS NAN with live probiotic culture , when compared with Pelargon , acidified NAN , and NAN , significantly reduced the incidence of Enterobacter pulmonary colonization ( P < .01 ) , bacterial translocation ( liver , P < .025 ; spleen and MLN , P < .05 ) , and gastric and intestinal colonization ( P < .001 for both ) . CONCLUSION Probiotic-fortified formula provides superior protection against pulmonary and gastrointestinal bacterial colonization and translocation compared with neutral and acidified formulas , and is equally tolerated
Due to the small number and the limitations of the included studies the results do not provide conclusive evidence as to the effect of prosthetic margin placement on the incidence of secondary caries
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