[Clinical observation on abdominal acupuncture plus Madopa for treatment of Parkinson's disease]. Acupuncture treatment of Parkinson's disease--a report of 29 cases. Effect of acupuncture on the auditory evoked brain stem potential in Parkinson's disease. [Effects of acupuncture on behavior and striatal apoptosis in mice with Parkinson disease]. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials [Observation on therapeutic effect of acupuncture combined with medicine on Parkinson disease]. [Effects of head point-through-point electroacupuncture on SOD and LPO in the patient of Parkinson's disease]. The effect of acupuncture on mood and working memory in patients with depression and schizophrenia. [A multi-centered randomized double-blinded controlled clinical study on efficacy of gulling pa'an capsule in treating Parkinson's disease]. [Therapeutic effect of scalp electroacupuncture on Parkinson disease].
OBJECTIVE To find out an effective therapy for Parkinson 's disease . METHODS Sixty cases were r and omly divided into an abdominal acupuncture group and a control group , 30 cases in each group . The abdominal acupuncture group were treated with Madopa and abdominal acupuncture at Zhongwan ( CV 12 ) , Xiawan ( CV 10 ) , Qi-hai ( CV 6 ) and Guanyuan ( CV 4 ) , etc . ; and the control group were treated with Madopa . RESULTS After treatment of 3 courses , the effective rate was 90.0 % in the abdominal acupuncture group and 83.3 % in the control group with a significant difference between the two groups ( P<0.05 ) . CONCLUSION Abdominal acupuncture combined with Madopa can elevate therapeutic effect of Madopa and reduce adverse effects of Madopa for the patient of primary Parkinson 's disease It can be concluded that acupuncture possesses definite therapeutic effectiveness for Parkinson 's disease , which is mainly represented by improvement in the clinical symptoms and signs , delaying of the disease 's progression , decrease in the dosage of anti-parkinsonian drug , and expectant treatment of the complications and symptoms induced by the drug side-effects Under the auditory evoked brain stem potential ( ABP ) examination , the latent period of V wave and the intermittent periods of III-V peak and I-V peak were significantly shortened in Parkinson 's disease patients of the treatment group ( N = 29 ) after acupuncture treatment . The difference of cumulative scores in Webster 's scale was also decreased in correlation analysis . The increase of dopamine in the brain and the excitability of the dopamine neurons may contribute to the therapeutic effects , in TCM terms , of subduing the pathogenic wind and tranquilizing the mind OBJECTIVE To observe the effect of acupuncture of " Baihui " ( GV 20 ) , " Fengfu " ( GV 16 ) and " Yanglingquan " ( GB 34 ) on behavior and striatal apoptosis in Parkinson disease ( PD ) mice . METHODS Twenty-eight adult male C57/ BL mice were r and omly divided into normal control , PD model , acupuncture and medication ( Levodopa and Benserazide Hydrochloride ) groups . Acupuncture was applied to " Baihui"(GV 20 ) , " Fengfu " ( GV 16 ) and electroacupuncture ( 2 Hz , 1 mA ) was applied to " Yanglingquan"(GB 34 ) for 15 min , once a day for 14 days . PD model was duplicated by intragastric administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ( MPTP ) . The locomotor test , pole test and swimming test were conducted for assessing the animals ' locomotion behavior before and after MPTP administration and after the treatment . The apoptotic neurons of the striatum were detected by terminal deoxyncleotidyl transferase-mediated dUTP-biotin nick end labeling assay . RESULTS In comparison with the normal control group , the pole test score and apoptotic neuronal percentage were increased significantly ( P<0.01 ) , and the locomotor count , swimming test score were decreased remarkably in the model group ( P<0.01 ) . Compared with the model group , the locomotor counts and swimming test scores were increased obviously ( P<0.05 , P<0.01 ) and the pole test scores decreased apparently ( P<0.05 ) in both acupuncture and medication groups after the treatment . No significant differences were found between the acupuncture and medication groups in the motor behavior ( P>0.05 ) . The effect of acupuncture was significantly superior to that of the medication in reducing neuronal apoptosis of the striatum ( P<0.01 ) . CONCLUSION Acupuncture of " Baihui " ( GV 20 ) , " Fengfu " ( GV 16 ) and " Yanglingquan"(GB 34 ) can improve PD mice 's locomotor function , which is closely associated with its function in reducing neuronal apoptosis of the striatum Flaws in the design , conduct , analysis , and reporting of r and omised trials can cause the effect of an intervention to be underestimated or overestimated . The Cochrane Collaboration ’s tool for assessing risk of bias aims to make the process clearer and more OBJECTIVE To observe therapeutic effect of acupuncture on Parkinson disease ( PD ) . METHODS Sixty cases of PD were r and omly divided into 2 groups , an acupuncture plus medication group and a medication group , 30 cases in each group . The acupuncture plus medication group were treated with acupuncture at Shenting ( GV 24 ) , Baihui ( GV 20 ) , Sishencong ( EX-HN 1 ) , etc . and oral administration of Madopa , and the medication group only with Madopa . Their therapeutic effect and scores of Parkinson disease function rating scale ( modified UPDRS ) were compared . RESULTS The total improvement rate of 80.0 % in the acupuncture plus medication group was significantly higher than 60.0 % in the medication group ( P < 0.05 ) ; the decrease of cumulative score of UPDRS in the acupuncture plus medication group was better than that in the medication group ( P < 0.05 ) . CONCLUSION Acupuncture has a certain therapeutic effect on PD OBJECTIVE To observe clinical therapeutic effect of head point-through-point electroacupuncture on Parkinson 's disease and the mechanism . METHODS Seventy-six cases of Parkinson 's disease were r and omly divided into a treatment group ( n=37 ) treated with head point-through-point electroacupuncture and oral administration of madopa , and a control group ( n=39 ) with only oral administration of madopa .  Superoxide dismutase ( SOD ) and lipids peroxides ( LPO ) were determined before and after treatment . RESULTS The effective rate was 97.3 % in the treatment group and 61.5 % in the control group with a very significant difference between the two groups ( P < 0.01 ) . SOD activity and LPO content were significantly improved after treatment in the treatment group ( P < 0.01 ) , with a significant difference between the two groups ( P < 0.01 ) . CONCLUSION Head point-through-point electroacupuncture can improve SOD activity and LPO content in the body so as to cure Parkinson 's disease BACKGROUND In patients with depression , as well as in patients with schizophrenia , both mood and working memory performance are often impaired . Both issues can only be addressed and improved with medication to some extent . OBJECTIVE This study investigates the mood and the working memory performance in patients with depression or schizophrenia and whether acupuncture can improve these . DESIGN , SETTING , PARTICIPANTS AND INTERVENTIONS A pragmatic clinical trial design was used . The study was conducted in a psychiatric clinic . Fifty patients with depression and 50 with schizophrenia were r and omly divided into an experimental and a waiting-list group . Additionally , 25 healthy control participants were included . Twelve weeks of individualized acupuncture treatment was used as the clinical intervention . MAIN OUTCOME MEASURES All patients were tested before ( T1 ) and after ( T2 ) acupuncture treatment on a mood scale ( Beck Depression Inventory-II , BDI-II ) , a simple working memory task ( digit span ) , and a complex working memory task ( letter-number sequencing ) ; the healthy controls were tested at T1 only . RESULTS Patients with depression scored worse than the others on the BDI-II , and patients with schizophrenia scored worse than the healthy controls . On the digit span , patients with schizophrenia did not differ from healthy controls whereas they scored worse of all on the letter-number sequencing . With respect to the acupuncture findings , first , the present study showed that the use of acupuncture to treat patients with schizophrenia was both practical and safe . Moreover , acupuncture had a positive effect on the BDI-II for the depression group , but acupuncture had no effect on the digit span and on the letter-number sequencing performance for the two clinical groups . CONCLUSION The clinical improvement in patients with depression after acupuncture treatment was not accompanied by any significant change in a simple working memory task or in a more complex working memory task ; the same was true for the patients with schizophrenia . TRIAL REGISTRATION Dutch Trial Register NTR3132 OBJECTIVE To objective ly evaluate the clinical efficacy of Gulling Pa'an Capsule ( GPC ) , a Chinese medicine , in treating Parkinson 's disease ( PD ) . METHODS According to the good clinical practice ( GCP ) principle , a multi-centered , double-blinded , layered , r and omized and grouping-controlled clinical trial was carried out from May 2002 to January 2005 on 242 PD patients . Among them , 53 patients who had never received levodopa were r and omized into two groups , 28 in group A treated with GPC , and 25 in group B treated with placebo ; patients who had received levodopa were assigned depending on the Hoehn & Yahr ( H-Y ) grade , to 4 groups , 75 and 19 of grade 1.5 -3 in group C and E , respectively , 79 and 16 of grade 4 in group D and F , respectively , patients in group C and E were treated with GPC and Levodopa , and those in group D and F treated with placebo and Levodopa for control . The treatment course was 12 weeks for all . Changes of unified Parkinson 's disease rating scale ( UPDRS ) II/III scores in comparing with the baseline were assessed . For the groups C , D , E and F , the dosage of levodopa administered was also recorded . Meanwhile , the blood pressure , pulse rate , blood and urine routine , liver and renal functions , electrocardiogram ( ECG ) and adverse reactions were monitored as the indices for safety supervise . RESULTS ( 1 ) After treatment , symptoms were markedly improved in 1 out of the 28 patients in group A and improved in 11 , the markedly improving rate was 3.6 % and the improving rate 39.3 % ; while in group B , the corresponding outcomes were 0 ( 0/25 ) and 28.0 % ( 7/25 ) respectively , showing insignificant difference between the two groups . UPDRS scores , including the total , II and III scores were all significantly lowered in group A after treatment ( P < 0.01 , P < 0.05 ) ; while in group B , significant lowering only showed in terms of UPDRS III ( P < 0.05 ) ; but the inter-group comparison of the changes in all the three items showed no significant difference . ( 2 ) The significant improving rate was 12.0 % ( 9/75 ) and improving rate 48.0 % ( 36/75 ) in group C , while those in group D , 12.7 % ( 10/79 ) and 24.1 % ( 19/79 ) respectively , the efficacy in group C was better ( P < 0.05 ) . The items of 3 UPDRS scores in groups C and D were all significantly lowered after treatment ( P < 0.01 ) , and the lowering in group C was more significant in terms of the total and II scores ( P < 0.05 ) . ( 3 ) The significant improving rate was 5.3 % ( 1/19 ) and improving rate 36.8 % ( 7/19 ) in group E , while in group F 0 % ( 0/19 ) and 25.0 % ( 4/16 ) , respectively , showing insignificant difference between them ; UPDRS scores lowered significantly in the two groups after treatment ( P < 0.01 ) , also showed no statistical significance in comparison ( P > 0.05 ) . ( 4 ) The dosage of Levodopa required in groups C and E was significantly reduced after treatment ( P < 0.05 ) , while in groups D and F , it was unchanged ( P > 0.05 ) ; yet , the further analysis displayed that significant reduction only presented in group C ( P < 0.05 ) , not in the other three groups . CONCLUSIONS The overall efficacy of levodopa in combined with GPC for treating PD patients of H-Y grade 1.5 -3 is significantly higher than that of levodopa alone . GPC shows obvious effects in improving patients ' motor syndrome and the quality of life ; as used in combining with levodopa , the dosage of levodopa required could be reduced OBJECTIVE To observe the therapeutic effect of scalp electroacupuncture on Parkinson disease ( PD ) of grade 1.5 - 3.0 on Hoehn-Yahr scale . METHODS Thirty patients with Parkinson disease were r and omized equally into the treatment group and control group . Patients in the treatment group were treated by scalp eletroacupuncture at the contralateral points of MS6 , MS4 , MS8 , MS9 and MS14 in cases of unilateral lesions or at the bilateral points for bilateral lesions , with also medication with Madopar . The patients in the control group were given Madopar only . The scores of Webster scale and the motor function of United Parkinson 's Disease Rating Scale ( UPDRS ) were used to for assessment before and after the therapeutic course ( 6 weeks ) . RESULTS Tremor , rigidity and bradykinesia were obviously improved in both the groups ( P<0.05 ) . The difference in the score of Webster scale was not significant between the two groups ( P>0.05 ) , but the treatment group showed greater improvement in motor functions than the control group ( P<0.05 ) . CONCLUSION Scalp electroacupuncture is effective and safe for therapy of Parkinson disease
Background : Parkinson 's disease ( PD ) is the second-most-common chronic and progressive neurodegenerative disease .
The long-term use of levodopa leads to a loss of efficacy and to complications .
Therefore , many patients with PD have turned to complementary therapies to help relieve their symptoms .
Acupuncture is most commonly used as a complementary therapy in patients with PD .
This paper presents a systematic review and meta- analysis of the effects of acupuncture for patients with PD .
This study was performed to summarize and evaluate evidence regarding the effectiveness of acupuncture in the relief of PD symptoms .