In this paper, we extend the guidelines of Venkatesh et al. (2013) for mixed-methods research by identifying and integrating variations in mixed-methods research. By considering 14 properties of mixed-methods research (e.g., purposes, research questions, epistemological assumptions), our guidelines demonstrate how researchers can flexibly identify the existing variations in mixed-methods research and proceed accordingly with a study design that suits their needs. To make the guidelines actionable for various situations and issues that researchers could encounter, we develop a decision tree to map the flow and relationship among the design strategies. We also illustrate one possible type of mixed-methods research in information systems in depth and discuss how to develop and validate metainferences as the outcomes of such a study.