Pixel-wise image segmentation is demanding task in computer vision. Classical U-Net architectures composed of encoders and decoders are very popular for segmentation of medical images, satellite images etc. Typically, neural network initialized with weights from a network pre-trained on a large data set like ImageNet shows better performance than those trained from scratch on a small dataset. In some practical applications, particularly in medicine and traffic safety, the accuracy of the models is of utmost importance. In this paper, we demonstrate how the U-Net type architecture can be improved by the use of the pretrained encoder. Our code and corresponding pre-trained weights are publicly available at https://github.com/ternaus/TernausNet. We compare three weight initialization schemes: LeCun uniform, the encoder with weights from VGG11 and full network trained on the Carvana dataset. This network architecture was a part of the winning solution (1st out of 735) in the Kaggle: Carvana Image Masking Challenge. Keywords—Computer Vision, Image Segmentation, Image Recognition, Deep learning, Medical Image Processing, Satellite Imagery.