[Controlled double-blind study on the efficacy of clofedanol-sobrerol in the treatment of pediatric pertussis]. A double-blind clinical trial on diphenhydramine in pertussis. Steroids in treatment of pertussis. A controlled clinical trial. Salbutamol vs. placebo for treatment of pertussis. Whooping cough treated with pertussis immune serum, human; report on a controlled series of 52 patients under 1 year of age. Salbutamol and pertussis. Is pertussis immune globulin efficacious for the treatment of hospitalized infants with pertussis? No answer yet.
nan nan nan The efficacy of salbutamol was assessed in a double blind placebo controlled crossover study in nine hospitalized children with whooping cough in the convulsive stage verified by culture or serology. The children were 1.5 to 27 months old (median, 4 months). The dosage of salbutamol was the one normally used and supplementary treatment was standardized. Salbutamol was found to give no significant effects on the course or severity of whooping cough in the children treated. nan nan In a multicenter, randomized, placebo-controlled clinical trial of pertussis immune globulin, intravenous (P-IGIV), 25 infants hospitalized with pertussis were enrolled in 24 months (15% of the target sample size) before the study was prematurely terminated because of expiration of the P-IGIV lots and unavailability of additional study product. Although well tolerated, there was no difference in the number or rate of improvement of symptoms (paroxysmal cough, whoop, apnea, bradycardia, oxygen desaturations) in P-IGIV recipients compared with placebo.
There is insufficient evidence to draw conclusions about the effectiveness of interventions for the cough in whooping cough.