Rh-o (D) immune globulin (human). Evaluation in women at risk of Rh immunization. Prevention of primary Rh immunization: first report of the Western Canadian trial, 1966-1968. Prevention of rhesus immunization. A controlled clinical trial with a comparatively low dose of anti-D immunoglobulin.
nan nan A controlled clinical trial was carried out to test the effectiveness of a comparatively low dose of anti-D immunoglobulin (250 mug) in preventing rhesus immunization.In the control group 17 out of 329 women (5%) formed rhesus antibodies, whereas in the treated group only 3 out of 333 women (0.9%) showed active immunization, all three of whom had an exceptionally large transplacental bleeding.
Anti-D, given within 72 hours after childbirth, reduces the risk of RhD alloimmunisation in Rhesus negative women who have given birth to a Rhesus positive infant. However the evidence on the optimal dose is limited.