The cost effectiveness of dextranomer and eusol in the treatment of infected surgical wounds. Dextranomer (Debrisan) paste in post-operative wounds. A controlled study. Treatment of infected surgical wounds with Varidase. Report of a prospective trial of dextranomer beads (Debrisan) and silicone foam elastomer (Silastic) dressings in surgical wounds. [Debrisan compared with chloramine packs in the treatment of postoperative wounds].
nan The clinical effect of dextranomer paste (Debrisan) in post-operative wounds (20 patients) was compared with the standard treatment in our department (polyvinylpyrrolidone, 20 patients) in a randomized study. All variables dealing with cleansing, inflammation-reducing effect and signs of ongoing healing were studied. Dextranomer paste appeared to be significantly better than polyvinylpyrrolidone in wounds with a high degree of pus and debris. No side-effects were observed in the dextranomer paste group. One patient in the control group showed an allergic reaction (oedema and erythema) and was withdrawn from the study. In 18 patients with subcutaneous wound infection after laparotomy the wounds were randomly treated with normal saline solution or with Varidase solution after complete opening, according to a double-blind system. Treatment was discontinued when the wound was clean enough for secondary suture or the patient could be discharged from hospital. Three patients, in whom the treatment was not completed because of intercurrent complications, were excluded from the evaluation. When the double-blind code was broken, 11 patients were found to have received saline treatment and 7 Varidase. The duration of the wound-dressing periods averaged 13.45 +/- 6.77 days in the former group and 5.00 +/- 2.16 in the latter. The difference is statistically significant. A prospective randomized controller trial of dextranomer beads (Debrisan) and silicone foam elastomer (Silastic) dressings in open infected surgical wounds has been performed. The results indicate that the healing time for wounds treated by Debrisan (n = 25) and elastomer (n = 25) is similar, being 40.92 +/- 3.98 and 36.90 +/- 3.18 days respectively. The time taken for wounds to become pain-free was similar in both treatment groups, as was the persistence of signs in the wounds of erythema, oedema and slough. Comparison of cost reveals the elastomer dressing to be considerably cheaper than Debrisan. nan
There is a lack of large, high-quality published RCTs evaluating debridement per se, or comparing different methods of debridement for surgical wounds, to guide clinical decision-making.