Early weaning from incubator and early discharge of preterm infants: randomized clinical trial. Weaning of premature infants from the incubator to an open crib. Thermal environment change in growing premature infants: effect on general somatic growth and subcutaneous fat accumulation.
The goal was to assess the feasibility of earlier weaning from the incubator for preterm infants.
                This was a prospective, randomized study with preterm infants with birth weights of <1600 g who were admitted to a neonatal subintensive ward. Findings for 47 infants who were transferred from an incubator to an open crib at >1600 g (early transition group) were compared with those for 47 infants who were transferred from an incubator to an open crib at >1800 g (standard transition [ST] group). The primary outcome of the study was length of stay. Secondary outcomes were the number of infants returned to an incubator, the growth velocity in an open crib and during the first week at home, the proportions of breastfeeding at discharge and during the first week at home, and the hospital readmission rate.
                The length of stay was significantly shorter in the early transition group than in the standard transition group (23.5 vs 33 days; P=.0002). No infants required transfer back to the incubator. Only 1 infant in the standard transition group was readmitted to the hospital during the first week after discharge. Growth velocities and individual amounts of breastfeeding were similar between the 2 groups.
                In this study, weaning of moderately preterm infants from incubators to open cribs at 1600 g was safe and resulted in earlier discharge. Thirty pairs of healthy, growing preterm infants were included in this randomized prospective study comparing thermal weaning at 1700 g with that at 1800 g. Based on an intention-to-treat analysis, infants weaned at 1700 g were discharged 1.1 days sooner than those weaned at 1800 g. However, this result was not statistically significant (p = 0.13). On the other hand, differences are apparent between treatments in some strata based on birth weight (p = 0.0056). Evidence also existed that time from entry (at 1500 g) to discharge depended on birth weight stratum (p = 0.010). No infant in either group lost weight after successful weaning, and mean 24-hour weight gains were similar for both groups. Two infants were weaned at 1800 g requiring return to the incubator due to hypothermia, and four infants weaned at 1700 g likewise requiring return to the incubator. The number weaned at 1700 g who had birth weight of 1000 g or less and who developed hypothermia appeared substantial (three of six such infants). Thus, it appears that thermal weaning at 1700 g may be safe and effective only for prematures with birth weight above 1000 g. Additional study appears needed. Fourteen growing, healthy premature infants were moved from heated incubators to cribs at different points in their growth. Group A (six babies) was moved when babies reached a weight of 1,600 to 1,700 gm; group B (eight babies) when babies reached a weight of 1,800 to 1,900 gm. All other conditions of rearing were kept the same. The effect on their growth and thermal stability was measured during the week before and after the temperature change. All infants tolerated the change well. There was no drop in abdominal temperature in an environment cooler by 5 C. The rate of weight gain correlated with gross energy intake only and did not differ within or between the two groups. The rate of growth of the skinfolds increased dramatically after the infants were moved from the incubator. A cooler environment in a growing premature infant (weight greater than 1,600 gm) may promote faster deposition of subcutaneous fat. This might be an important factor in efficient gain in cold resistance.