url: =Patent US6750054 - Nuclelotide sequences coding preferential polypeptide; for use in human ... - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsNovel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic application....http://www.google.com/patents/US6750054?utm_source=gb-gplus-sharePatent US6750054 - Nuclelotide sequences coding preferential polypeptide; for use in human therapeutics, diagnostics and pharmacologyAdvanced Patent SearchPublication numberUS6750054 B2Publication typeGrantApplication numberUS 09/854,845Publication dateJun 15, 2004Filing dateMay 14, 2001Priority dateMay 18, 2000Fee statusLapsedAlso published asUS7199221, US20020098491, US20050054040, WO2001088133A2, WO2001088133A3Publication number09854845, 854845, US 6750054 B2, US 6750054B2, US-B2-6750054, US6750054 B2, US6750054B2InventorsD. Wade Walke, Xiaoming Wang, John Scoville, C. Alexander Turner, Jr.Original AssigneeLexicon Genetics IncorporatedExport CitationBiBTeX, EndNote, RefManPatent Citations (27), Non-Patent Citations (48), Classifications (7), Legal Events (4) External Links: USPTO, USPTO Assignment, EspacenetNuclelotide sequences coding preferential polypeptide; for use in human therapeutics, diagnostics and pharmacologyUS 6750054 B2Abstract Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic application.\n# SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 50 <210> SEQ ID NO 1 <211> LENGTH: 3150 <212> TYPE: DNA <213> ORGANISM: homo sapiens <400> SEQUENCE: 1 atgacggtgg ttaatccaca agacctgcag ccgtgggtct ctaacttcac ct #accctgga 60 gcccgggatt tctcccagct ggctttggac ccctccgggr accagctcat cg #tgggagcc 120 aggaactacc tcttcagact cagccttgcc aatgtctctc ttcttcaggc ca #cagagtgg 180 gcctccagtg aggacacgcg ccgctcctgc caaagcaaag ggaagactga gg #aggagtgt 240 cagaactacg tgcgagtcct gatcgtcgcc ggccggaagg tgttcatgtg tg #gaaccaat 300 gccttttccc ccatgtgcac cagcagacag gtggggaacc tcagccggac ta #ttgagaag 360 atcaatggtg tggcccgctg cccctatgac ccacgccaca actccacagc tg #tcatctcc 420 tcccaggggg agctctatgc agccacggtc atcgacttct caggtcggga cc #ctgccatc 480 taccgcagcc tgggcagtgg gccaccgctt cgcactgccc aatataactc ca #agtggctt 540 aatgagccaa acttcgtggc agcctatgat attgggctgt ttgcatactt ct #tcctgcgg 600 gagaacgcag tggagcacga ctgtggacgc accgtgtact ctcgcgtggc cc #gcgtgtgc 660 aagaatgacg tggggggccg attcctgctg gaggacacat ggaccacatt ca #tgaaggcc 720 cggctcaact gctcccgccc gggcgaggtc cccttctact ataacgagct gc #agagtgcc 780 ttccacttgc crgagcagga cctcatctat ggagttttca caaccaacgt aa #acagcaty 840 gcggcttctg ctgtctgcgc cttcaacctc agtgctatct cccaggcttt ca #atggccca 900 tttcgctacc aggagaaccc cagggctgcc tggctcccca tagccaaccc ca #tccccaat 960 ttccagtgtg gcaccctgcc tgagaccggt cccaacgaga acctgacgga gc #gcagcctg 1020 caggacgcgc agcgcctctt cctgatgagc gaggccgtgc agccggtgac ac #ccgagccc 1080 tgtgtcaccc aggacagcgt gcgcttctca cacctcgtgg tggacctggt gc #aggctaaa 1140 gacacgctct accatgtact ctacattggc accgagtcgg gcaccatcct ga #aggcgctg 1200 tccacggcga gccgcagcct ccacggctgc tacctggagg agctgcacgt gc #tgcccccc 1260 gggcgccgcg agcccctgcg cagcctgcgc atcctgcaca gcgcccgcgc gc #tcttcgtg 1320 gggctgagag acggcgtcct gcgggtccca ctggagaggt gcgccgccta cc #gcagccag 1380 ggggcatgcc tgggggcccg ggacccgtac tgtggctggg acgggaagca gc #aacgttgc 1440 agcacactcg aggacagctc caacatgagc ctctggaccc agaacatcac cg #cctgtcct 1500 gtgcggaatg tgacacggga tgggggcttc ggcccatggt caccatggca ac #catgtgag 1560 cacttggatg gggacaactc aggctcttgc ctgtgtcgag ctcgatcctg tg #attcccct 1620 cgaccccgct gtgggggcct tgactgcctg gggccagcca tccacatcgc ca #actgctcc 1680 aggaatgggg cgtggacccc gtggtcatcg tgggcgctgt gcagcacgtc ct #gtggcatc 1740 ggcttccagg tccgccagcg aagttgcagc aaccctgctc cccgccacgg gg #gccgcatc 1800 tgcgtgggca agagccggga ggaacggttc tgtaatgaga acacgccttg cc #cggtgccc 1860 atcttctggg cttcctgggg ctcctggagc aagtgcagca gcaactgtgg ag #ggggcatg 1920 cagtcgcggc gtcgggcctg cgagaacggc aactcctgcc tgggctgcgg cg #tggagttc 1980 aagacgtgca accccgaggg ctgccccgaa gtgcggcgca acaccccctg ga #cgccgtgg 2040 ctgcccgtga acgtgacgca gggcggggca cggcaggagc agcggttccg ct #tcacctgc 2100 cgcgcgcccc ttgcagaccc gcacggcctg cagttcggca ggagaaggac cg #agacgagg 2160 acctgtcccg cggacggctc cggctcctgc gacaccgacg ccctggtgga gg #acctcctg 2220 cgcagcggga gcacctcccc gcacacggtg agcgggggct gggccgcctg gg #gcccgtgg 2280 tcgtcctgct cccgggactg cgagctgggc ttccgcgtcc gcaagagaac gt #gcactaac 2340 ccggagcccc gcaacggggg cctgccctgc gtgggcgatg ctgccgagta cc #aggactgc 2400 aacccccagg cttgcccagt tcggggtgct tggtcctgct ggacctcatg gt #ctccatgc 2460 tcagcttcct gtggtggggg tcactatcaa cgcacccgtt cctgcaccag cc #ccgcaccc 2520 tccccaggtg aggacatctg tctcgggctg cacacggagg aggcactatg tg #ccacacag 2580 gcctgcccag aaggctggtc gccctggtct gagtggagta agtgcactga cg #acggagcc 2640 cagagccgaa gccggcactg tgaggagctc ctcccagggt ccagcgcctg tg #ctggaaac 2700 agcagccaga gccgcccctg cccctacagc gagattcccg tcatcctgcc ag #cctccagc 2760 atggaggagg ccaccggctg tgcagggttc aatctcatcc acttggtggc ca #cgggcatc 2820 tcctgcttct tgggctctgg gctcctgacc ctagcagtgt acctgtcttg cc #agcactgc 2880 cagcgtcagt cccaggagtc cacactggtc catcctgcca cccccaacca tt #tgcactac 2940 aagggcggag gcaccccgaa gaatgaaaag tacacaccca tggaattcaa ga #ccctgaac 3000 aagaataact tgatccctga tgacagagcc aacttctacc cattgcagca ga #ccaatgtg 3060 tacacgacta cttactaccc aagccccctg aacaaacaca gcttccggcc cg #aggcctca 3120 cctggacaac ggtgcttccc caacagctga # # 3150 <210> SEQ ID NO 2 <211> LENGTH: 1049 <212> TYPE: PRT <213> ORGANISM: homo sapiens <400> SEQUENCE: 2 Met Thr Val Val Asn Pro Gln Asp Leu Gln Pr #o Trp Val Ser Asn Phe 1 5 # 10 # 15 Thr Tyr Pro Gly Ala Arg Asp Phe Ser Gln Le #u Ala Leu Asp Pro Ser 20 # 25 # 30 Gly Asn Gln Leu Ile Val Gly Ala Arg Asn Ty #r Leu Phe Arg Leu Ser 35 # 40 # 45 Leu Ala Asn Val Ser Leu Leu Gln Ala Thr Gl #u Trp Ala Ser Ser Glu 50 # 55 # 60 Asp Thr Arg Arg Ser Cys Gln Ser Lys Gly Ly #s Thr Glu Glu Glu Cys 65 #70 #75 #80 Gln Asn Tyr Val Arg Val Leu Ile Val Ala Gl #y Arg Lys Val Phe Met 85 # 90 # 95 Cys Gly Thr Asn Ala Phe Ser Pro Met Cys Th #r Ser Arg Gln Val Gly 100 # 105 # 110 Asn Leu Ser Arg Thr Ile Glu Lys Ile Asn Gl #y Val Ala Arg Cys Pro 115 # 120 # 125 Tyr Asp Pro Arg His Asn Ser Thr Ala Val Il #e Ser Ser Gln Gly Glu 130 # 135 # 140 Leu Tyr Ala Ala Thr Val Ile Asp Phe Ser Gl #y Arg Asp Pro Ala Ile 145 1 #50 1 #55 1 #60 Tyr Arg Ser Leu Gly Ser Gly Pro Pro Leu Ar #g Thr Ala Gln Tyr Asn 165 # 170 # 175 Ser Lys Trp Leu Asn Glu Pro Asn Phe Val Al #a Ala Tyr Asp Ile Gly 180 # 185 # 190 Leu Phe Ala Tyr Phe Phe Leu Arg Glu Asn Al #a Val Glu His Asp Cys 195 # 200 # 205 Gly Arg Thr Val Tyr Ser Arg Val Ala Arg Va #l Cys Lys Asn Asp Val 210 # 215 # 220 Gly Gly Arg Phe Leu Leu Glu Asp Thr Trp Th #r Thr Phe Met Lys Ala 225 2 #30 2 #35 2 #40 Arg Leu Asn Cys Ser Arg Pro Gly Glu Val Pr #o Phe Tyr Tyr Asn Glu 245 # 250 # 255 Leu Gln Ser Ala Phe His Leu Pro Glu Gln As #p Leu Ile Tyr Gly Val 260 # 265 # 270 Phe Thr Thr Asn Val Asn Ser Ile Ala Ala Se #r Ala Val Cys Ala Phe 275 # 280 # 285 Asn Leu Ser Ala Ile Ser Gln Ala Phe Asn Gl #y Pro Phe Arg Tyr Gln 290 # 295 # 300 Glu Asn Pro Arg Ala Ala Trp Leu Pro Ile Al #a Asn Pro Ile Pro Asn 305 3 #10 3 #15 3 #20 Phe Gln Cys Gly Thr Leu Pro Glu Thr Gly Pr #o Asn Glu Asn Leu Thr 325 # 330 # 335 Glu Arg Ser Leu Gln Asp Ala Gln Arg Leu Ph #e Leu Met Ser Glu Ala 340 # 345 # 350 Val Gln Pro Val Thr Pro Glu Pro Cys Val Th #r Gln Asp Ser Val Arg 355 # 360 # 365 Phe Ser His Leu Val Val Asp Leu Val Gln Al #a Lys Asp Thr Leu Tyr 370 # 375 # 380 His Val Leu Tyr Ile Gly Thr Glu Ser Gly Th #r Ile Leu Lys Ala Leu 385 3 #90 3 #95 4 #00 Ser Thr Ala Ser Arg Ser Leu His Gly Cys Ty #r Leu Glu Glu Leu His 405 # 410 # 415 Val Leu Pro Pro Gly Arg Arg Glu Pro Leu Ar #g Ser Leu Arg Ile Leu 420 # 425 # 430 His Ser Ala Arg Ala Leu Phe Val Gly Leu Ar #g Asp Gly Val Leu Arg 435 # 440 # 445 Val Pro Leu Glu Arg Cys Ala Ala Tyr Arg Se #r Gln Gly Ala Cys Leu 450 # 455 # 460 Gly Ala Arg Asp Pro Tyr Cys Gly Trp Asp Gl #y Lys Gln Gln Arg Cys 465 4 #70 4 #75 4 #80 Ser Thr Leu Glu Asp Ser Ser Asn Met Ser Le #u Trp Thr Gln Asn Ile 485 # 490 # 495 Thr Ala Cys Pro Val Arg Asn Val Thr Arg As #p Gly Gly Phe Gly Pro 500 # 505 # 510 Trp Ser Pro Trp Gln Pro Cys Glu His Leu As #p Gly Asp Asn Ser Gly 515 # 520 # 525 Ser Cys Leu Cys Arg Ala Arg Ser Cys Asp Se #r Pro Arg Pro Arg Cys 530 # 535 # 540 Gly Gly Leu Asp Cys Leu Gly Pro Ala Ile Hi #s Ile Ala Asn Cys Ser 545 5 #50 5 #55 5 #60 Arg Asn Gly Ala Trp Thr Pro Trp Ser Ser Tr #p Ala Leu Cys Ser Thr 565 # 570 # 575 Ser Cys Gly Ile Gly Phe Gln Val Arg Gln Ar #g Ser Cys Ser Asn Pro 580 # 585 # 590 Ala Pro Arg His Gly Gly Arg Ile Cys Val Gl #y Lys Ser Arg Glu Glu 595 # 600 # 605 Arg Phe Cys Asn Glu Asn Thr Pro Cys Pro Va #l Pro Ile Phe Trp Ala 610 # 615 # 620 Ser Trp Gly Ser Trp Ser Lys Cys Ser Ser As #n Cys Gly Gly Gly Met 625 6 #30 6 #35 6 #40 Gln Ser Arg Arg Arg Ala Cys Glu Asn Gly As #n Ser Cys Leu Gly Cys 645 # 650 # 655 Gly Val Glu Phe Lys Thr Cys Asn Pro Glu Gl #y Cys Pro Glu Val Arg 660 # 665 # 670 Arg Asn Thr Pro Trp Thr Pro Trp Leu Pro Va #l Asn Val Thr Gln Gly 675 # 680 # 685 Gly Ala Arg Gln Glu Gln Arg Phe Arg Phe Th #r Cys Arg Ala Pro Leu 690 # 695 # 700 Ala Asp Pro His Gly Leu Gln Phe Gly Arg Ar #g Arg Thr Glu Thr Arg 705 7 #10 7 #15 7 #20 Thr Cys Pro Ala Asp Gly Ser Gly Ser Cys As #p Thr Asp Ala Leu Val 725 # 730 # 735 Glu Asp Leu Leu Arg Ser Gly Ser Thr Ser Pr #o His Thr Val Ser Gly 740 # 745 # 750 Gly Trp Ala Ala Trp Gly Pro Trp Ser Ser Cy #s Ser Arg Asp Cys Glu 755 # 760 # 765 Leu Gly Phe Arg Val Arg Lys Arg Thr Cys Th #r Asn Pro Glu Pro Arg 770 # 775 # 780 Asn Gly Gly Leu Pro Cys Val Gly Asp Ala Al #a Glu Tyr Gln Asp Cys 785 7 #90 7 #95 8 #00 Asn Pro Gln Ala Cys Pro Val Arg Gly Ala Tr #p Ser Cys Trp Thr Ser 805 # 810 # 815 Trp Ser Pro Cys Ser Ala Ser Cys Gly Gly Gl #y His Tyr Gln Arg Thr 820 # 825 # 830 Arg Ser Cys Thr Ser Pro Ala Pro Ser Pro Gl #y Glu Asp Ile Cys Leu 835 # 840 # 845 Gly Leu His Thr Glu Glu Ala Leu Cys Ala Th #r Gln Ala Cys Pro Glu 850 # 855 # 860 Gly Trp Ser Pro Trp Ser Glu Trp Ser Lys Cy #s Thr Asp Asp Gly Ala 865 8 #70 8 #75 8 #80 Gln Ser Arg Ser Arg His Cys Glu Glu Leu Le #u Pro Gly Ser Ser Ala 885 # 890 # 895 Cys Ala Gly Asn Ser Ser Gln Ser Arg Pro Cy #s Pro Tyr Ser Glu Ile 900 # 905 # 910 Pro Val Ile Leu Pro Ala Ser Ser Met Glu Gl #u Ala Thr Gly Cys Ala 915 # 920 # 925 Gly Phe Asn Leu Ile His Leu Val Ala Thr Gl #y Ile Ser Cys Phe Leu 930 # 935 # 940 Gly Ser Gly Leu Leu Thr Leu Ala Val Tyr Le #u Ser Cys Gln His Cys 945 9 #50 9 #55 9 #60 Gln Arg Gln Ser Gln Glu Ser Thr Leu Val Hi #s Pro Ala Thr Pro Asn 965 # 970 # 975 His Leu His Tyr Lys Gly Gly Gly Thr Pro Ly #s Asn Glu Lys Tyr Thr 980 # 985 # 990 Pro Met Glu Phe Lys Thr Leu Asn Lys Asn As #n Leu Ile Pro Asp Asp 995 # 1000 # 1005 Arg Ala Asn Phe Tyr Pro Leu Gln Gln Thr As #n Val Tyr Thr Thr Thr 1010 # 1015 # 1020 Tyr Tyr Pro Ser Pro Leu Asn Lys His Ser Ph #e Arg Pro Glu Ala Ser 1025 1030 # 1035 # 1040 Pro Gly Gln Arg Cys Phe Pro Asn Ser 1045 <210> SEQ ID NO 3 <211> LENGTH: 3282 <212> TYPE: DNA <213> ORGANISM: homo sapiens <400> SEQUENCE: 3 atggtgcttg caggccccct ggctgtctcg ctgttgctgc ccagcctcac ac #tgctggtg 60 tcccacctct ccagctccca ggatgtctcc agtgagccca gcagtgagca gc #agctgtgc 120 gcccttagca agcaccccac cgtggccttt gaagacctgc agccgtgggt ct #ctaacttc 180 acctaccctg gagcccggga tttctcccag ctggctttgg acccctccgg gr #accagctc 240 atcgtgggag ccaggaacta cctcttcaga ctcagccttg ccaatgtctc tc #ttcttcag 300 gccacagagt gggcctccag tgaggacacg cgccgctcct gccaaagcaa ag #ggaagact 360 gaggaggagt gtcagaacta cgtgcgagtc ctgatcgtcg ccggccggaa gg #tgttcatg 420 tgtggaacca atgccttttc ccccatgtgc accagcagac aggtggggaa cc #tcagccgg 480 actattgaga agatcaatgg tgtggcccgc tgcccctatg acccacgcca ca #actccaca 540 gctgtcatct cctcccaggg ggagctctat gcagccacgg tcatcgactt ct #caggtcgg 600 gaccctgcca tctaccgcag cctgggcagt gggccaccgc ttcgcactgc cc #aatataac 660 tccaagtggc ttaatgagcc aaacttcgtg gcagcctatg atattgggct gt #ttgcatac 720 ttcttcctgc gggagaacgc agtggagcac gactgtggac gcaccgtgta ct #ctcgcgtg 780 gcccgcgtgt gcaagaatga cgtggggggc cgattcctgc tggaggacac at #ggaccaca 840 ttcatgaagg cccggctcaa ctgctcccgc ccgggcgagg tccccttcta ct #ataacgag 900 ctgcagagtg ccttccactt gccrgagcag gacctcatct atggagtttt ca #caaccaac 960 gtaaacagca tygcggcttc tgctgtctgc gccttcaacc tcagtgctat ct #cccaggct 1020 ttcaatggcc catttcgcta ccaggagaac cccagggctg cctggctccc ca #tagccaac 1080 cccatcccca atttccagtg tggcaccctg cctgagaccg gtcccaacga ga #acctgacg 1140 gagcgcagcc tgcaggacgc gcagcgcctc ttcctgatga gcgaggccgt gc #agccggtg 1200 acacccgagc cctgtgtcac ccaggacagc gtgcgcttct cacacctcgt gg #tggacctg 1260 gtgcaggcta aagacacgct ctaccatgta ctctacattg gcaccgagtc gg #gcaccatc 1320 ctgaaggcgc tgtccacggc gagccgcagc ctccacggct gctacctgga gg #agctgcac 1380 gtgctgcccc ccgggcgccg cgagcccctg cgcagcctgc gcatcctgca ca #gcgcccgc 1440 gcgctcttcg tggggctgag agacggcgtc ctgcgggtcc cactggagag gt #gcgccgcc 1500 taccgcagcc agggggcatg cctgggggcc cgggacccgt actgtggctg gg #acgggaag 1560 cagcaacgtt gcagcacact cgaggacagc tccaacatga gcctctggac cc #agaacatc 1620 accgcctgtc ctgtgcggaa tgtgacacgg gatgggggct tcggcccatg gt #caccatgg 1680 caaccatgtg agcacttgga tggggacaac tcaggctctt gcctgtgtcg ag #ctcgatcc 1740 tgtgattccc ctcgaccccg ctgtgggggc cttgactgcc tggggccagc ca #tccacatc 1800 gccaactgct ccaggaatgg ggcgtggacc ccgtggtcat cgtgggcgct gt #gcagcacg 1860 tcctgtggca tcggcttcca ggtccgccag cgaagttgca gcaaccctgc tc #cccgccac 1920 gggggccgca tctgcgtggg caagagccgg gaggaacggt tctgtaatga ga #acacgcct 1980 tgcccggtgc ccatcttctg ggcttcctgg ggctcctgga gcaagtgcag ca #gcaactgt 2040 ggagggggca tgcagtcgcg gcgtcgggcc tgcgagaacg gcaactcctg cc #tgggctgc 2100 ggcgtggagt tcaagacgtg caaccccgag ggctgccccg aagtgcggcg ca #acaccccc 2160 tggacgccgt ggctgcccgt gaacgtgacg cagggcgggg cacggcagga gc #agcggttc 2220 cgcttcacct gccgcgcgcc ccttgcagac ccgcacggcc tgcagttcgg ca #ggagaagg 2280 accgagacga ggacctgtcc cgcggacggc tccggctcct gcgacaccga cg #ccctggtg 2340 gaggacctcc tgcgcagcgg gagcacctcc ccgcacacgg tgagcggggg ct #gggccgcc 2400 tggggcccgt ggtcgtcctg ctcccgggac tgcgagctgg gcttccgcgt cc #gcaagaga 2460 acgtgcacta acccggagcc ccgcaacggg ggcctgccct gcgtgggcga tg #ctgccgag 2520 taccaggact gcaaccccca ggcttgccca gttcggggtg cttggtcctg ct #ggacctca 2580 tggtctccat gctcagcttc ctgtggtggg ggtcactatc aacgcacccg tt #cctgcacc 2640 agccccgcac cctccccagg tgaggacatc tgtctcgggc tgcacacgga gg #aggcacta 2700 tgtgccacac aggcctgccc agaaggctgg tcgccctggt ctgagtggag ta #agtgcact 2760 gacgacggag cccagagccg aagccggcac tgtgaggagc tcctcccagg gt #ccagcgcc 2820 tgtgctggaa acagcagcca gagccgcccc tgcccctaca gcgagattcc cg #tcatcctg 2880 ccagcctcca gcatggagga ggccaccggc tgtgcagggt tcaatctcat cc #acttggtg 2940 gccacgggca tctcctgctt cttgggctct gggctcctga ccctagcagt gt #acctgtct 3000 tgccagcact gccagcgtca gtcccaggag tccacactgg tccatcctgc ca #cccccaac 3060 catttgcact acaagggcgg aggcaccccg aagaatgaaa agtacacacc ca #tggaattc 3120 aagaccctga acaagaataa cttgatccct gatgacagag ccaacttcta cc #cattgcag 3180 cagaccaatg tgtacacgac tacttactac ccaagccccc tgaacaaaca ca #gcttccgg 3240 cccgaggcct cacctggaca acggtgcttc cccaacagct ga # #3282 <210> SEQ ID NO 4 <211> LENGTH: 1093 <212> TYPE: PRT <213> ORGANISM: homo sapiens <400> SEQUENCE: 4 Met Val Leu Ala Gly Pro Leu Ala Val Ser Le #u Leu Leu Pro Ser Leu 1 5 # 10 # 15 Thr Leu Leu Val Ser His Leu Ser Ser Ser Gl #n Asp Val Ser Ser Glu 20 # 25 # 30 Pro Ser Ser Glu Gln Gln Leu Cys Ala Leu Se #r Lys His Pro Thr Val 35 # 40 # 45 Ala Phe Glu Asp Leu Gln Pro Trp Val Ser As #n Phe Thr Tyr Pro Gly 50 # 55 # 60 Ala Arg Asp Phe Ser Gln Leu Ala Leu Asp Pr #o Ser Gly Asn Gln Leu 65 #70 #75 #80 Ile Val Gly Ala Arg Asn Tyr Leu Phe Arg Le #u Ser Leu Ala Asn Val 85 # 90 # 95 Ser Leu Leu Gln Ala Thr Glu Trp Ala Ser Se #r Glu Asp Thr Arg Arg 100 # 105 # 110 Ser Cys Gln Ser Lys Gly Lys Thr Glu Glu Gl #u Cys Gln Asn Tyr Val 115 # 120 # 125 Arg Val Leu Ile Val Ala Gly Arg Lys Val Ph #e Met Cys Gly Thr Asn 130 # 135 # 140 Ala Phe Ser Pro Met Cys Thr Ser Arg Gln Va #l Gly Asn Leu Ser Arg 145 1 #50 1 #55 1 #60 Thr Ile Glu Lys Ile Asn Gly Val Ala Arg Cy #s Pro Tyr Asp Pro Arg 165 # 170 # 175 His Asn Ser Thr Ala Val Ile Ser Ser Gln Gl #y Glu Leu Tyr Ala Ala 180 # 185 # 190 Thr Val Ile Asp Phe Ser Gly Arg Asp Pro Al #a Ile Tyr Arg Ser Leu 195 # 200 # 205 Gly Ser Gly Pro Pro Leu Arg Thr Ala Gln Ty #r Asn Ser Lys Trp Leu 210 # 215 # 220 Asn Glu Pro Asn Phe Val Ala Ala Tyr Asp Il #e Gly Leu Phe Ala Tyr 225 2 #30 2 #35 2 #40 Phe Phe Leu Arg Glu Asn Ala Val Glu His As #p Cys Gly Arg Thr Val 245 # 250 # 255 Tyr Ser Arg Val Ala Arg Val Cys Lys Asn As #p Val Gly Gly Arg Phe 260 # 265 # 270 Leu Leu Glu Asp Thr Trp Thr Thr Phe Met Ly #s Ala Arg Leu Asn Cys 275 # 280 # 285 Ser Arg Pro Gly Glu Val Pro Phe Tyr Tyr As #n Glu Leu Gln Ser Ala 290 # 295 # 300 Phe His Leu Pro Glu Gln Asp Leu Ile Tyr Gl #y Val Phe Thr Thr Asn 305 3 #10 3 #15 3 #20 Val Asn Ser Ile Ala Ala Ser Ala Val Cys Al #a Phe Asn Leu Ser Ala 325 # 330 # 335 Ile Ser Gln Ala Phe Asn Gly Pro Phe Arg Ty #r Gln Glu Asn Pro Arg 340 # 345 # 350 Ala Ala Trp Leu Pro Ile Ala Asn Pro Ile Pr #o Asn Phe Gln Cys Gly 355 # 360 # 365 Thr Leu Pro Glu Thr Gly Pro Asn Glu Asn Le #u Thr Glu Arg Ser Leu 370 # 375 # 380 Gln Asp Ala Gln Arg Leu Phe Leu Met Ser Gl #u Ala Val Gln Pro Val 385 3 #90 3 #95 4 #00 Thr Pro Glu Pro Cys Val Thr Gln Asp Ser Va #l Arg Phe Ser His Leu 405 # 410 # 415 Val Val Asp Leu Val Gln Ala Lys Asp Thr Le #u Tyr His Val Leu Tyr 420 # 425 # 430 Ile Gly Thr Glu Ser Gly Thr Ile Leu Lys Al #a Leu Ser Thr Ala Ser 435 # 440 # 445 Arg Ser Leu His Gly Cys Tyr Leu Glu Glu Le #u His Val Leu Pro Pro 450 # 455 # 460 Gly Arg Arg Glu Pro Leu Arg Ser Leu Arg Il #e Leu His Ser Ala Arg 465 4 #70 4 #75 4 #80 Ala Leu Phe Val Gly Leu Arg Asp Gly Val Le #u Arg Val Pro Leu Glu 485 # 490 # 495 Arg Cys Ala Ala Tyr Arg Ser Gln Gly Ala Cy #s Leu Gly Ala Arg Asp 500 # 505 # 510 Pro Tyr Cys Gly Trp Asp Gly Lys Gln Gln Ar #g Cys Ser Thr Leu Glu 515 # 520 # 525 Asp Ser Ser Asn Met Ser Leu Trp Thr Gln As #n Ile Thr Ala Cys Pro 530 # 535 # 540 Val Arg Asn Val Thr Arg Asp Gly Gly Phe Gl #y Pro Trp Ser Pro Trp 545 5 #50 5 #55 5 #60 Gln Pro Cys Glu His Leu Asp Gly Asp Asn Se #r Gly Ser Cys Leu Cys 565 # 570 # 575 Arg Ala Arg Ser Cys Asp Ser Pro Arg Pro Ar #g Cys Gly Gly Leu Asp 580 # 585 # 590 Cys Leu Gly Pro Ala Ile His Ile Ala Asn Cy #s Ser Arg Asn Gly Ala 595 # 600 # 605 Trp Thr Pro Trp Ser Ser Trp Ala Leu Cys Se #r Thr Ser Cys Gly Ile 610 # 615 # 620 Gly Phe Gln Val Arg Gln Arg Ser Cys Ser As #n Pro Ala Pro Arg His 625 6 #30 6 #35 6 #40 Gly Gly Arg Ile Cys Val Gly Lys Ser Arg Gl #u Glu Arg Phe Cys Asn 645 # 650 # 655 Glu Asn Thr Pro Cys Pro Val Pro Ile Phe Tr #p Ala Ser Trp Gly Ser 660 # 665 # 670 Trp Ser Lys Cys Ser Ser Asn Cys Gly Gly Gl #y Met Gln Ser Arg Arg 675 # 680 # 685 Arg Ala Cys Glu Asn Gly Asn Ser Cys Leu Gl #y Cys Gly Val Glu Phe 690 # 695 # 700 Lys Thr Cys Asn Pro Glu Gly Cys Pro Glu Va #l Arg Arg Asn Thr Pro 705 7 #10 7 #15 7 #20 Trp Thr Pro Trp Leu Pro Val Asn Val Thr Gl #n Gly Gly Ala Arg Gln 725 # 730 # 735 Glu Gln Arg Phe Arg Phe Thr Cys Arg Ala Pr #o Leu Ala Asp Pro His 740 # 745 # 750 Gly Leu Gln Phe Gly Arg Arg Arg Thr Glu Th #r Arg Thr Cys Pro Ala 755 # 760 # 765 Asp Gly Ser Gly Ser Cys Asp Thr Asp Ala Le #u Val Glu Asp Leu Leu 770 # 775 # 780 Arg Ser Gly Ser Thr Ser Pro His Thr Val Se #r Gly Gly Trp Ala Ala 785 7 #90 7 #95 8 #00 Trp Gly Pro Trp Ser Ser Cys Ser Arg Asp Cy #s Glu Leu Gly Phe Arg 805 # 810 # 815 Val Arg Lys Arg Thr Cys Thr Asn Pro Glu Pr #o Arg Asn Gly Gly Leu 820 # 825 # 830 Pro Cys Val Gly Asp Ala Ala Glu Tyr Gln As #p Cys Asn Pro Gln Ala 835 # 840 # 845 Cys Pro Val Arg Gly Ala Trp Ser Cys Trp Th #r Ser Trp Ser Pro Cys 850 # 855 # 860 Ser Ala Ser Cys Gly Gly Gly His Tyr Gln Ar #g Thr Arg Ser Cys Thr 865 8 #70 8 #75 8 #80 Ser Pro Ala Pro Ser Pro Gly Glu Asp Ile Cy #s Leu Gly Leu His Thr 885 # 890 # 895 Glu Glu Ala Leu Cys Ala Thr Gln Ala Cys Pr #o Glu Gly Trp Ser Pro 900 # 905 # 910 Trp Ser Glu Trp Ser Lys Cys Thr Asp Asp Gl #y Ala Gln Ser Arg Ser 915 # 920 # 925 Arg His Cys Glu Glu Leu Leu Pro Gly Ser Se #r Ala Cys Ala Gly Asn 930 # 935 # 940 Ser Ser Gln Ser Arg Pro Cys Pro Tyr Ser Gl #u Ile Pro Val Ile Leu 945 9 #50 9 #55 9 #60 Pro Ala Ser Ser Met Glu Glu Ala Thr Gly Cy #s Ala Gly Phe Asn Leu 965 # 970 # 975 Ile His Leu Val Ala Thr Gly Ile Ser Cys Ph #e Leu Gly Ser Gly Leu 980 # 985 # 990 Leu Thr Leu Ala Val Tyr Leu Ser Cys Gln Hi #s Cys Gln Arg Gln Ser 995 # 1000 # 1005 Gln Glu Ser Thr Leu Val His Pro Ala Thr Pr #o Asn His Leu His Tyr 1010 # 1015 # 1020 Lys Gly Gly Gly Thr Pro Lys Asn Glu Lys Ty #r Thr Pro Met Glu Phe 1025 1030 # 1035 # 1040 Lys Thr Leu Asn Lys Asn Asn Leu Ile Pro As #p Asp Arg Ala Asn Phe 1045 # 1050 # 1055 Tyr Pro Leu Gln Gln Thr Asn Val Tyr Thr Th #r Thr Tyr Tyr Pro Ser 1060 # 1065 # 1070 Pro Leu Asn Lys His Ser Phe Arg Pro Glu Al #a Ser Pro Gly Gln Arg 1075 # 1080 # 1085 Cys Phe Pro Asn Ser 1090 <210> SEQ ID NO 5 <211> LENGTH: 3105 <212> TYPE: DNA <213> ORGANISM: homo sapiens <400> SEQUENCE: 5 atgacggtgg ttaatccaca agacctgcag ccgtgggtct ctaacttcac ct #accctgga 60 gcccgggatt tctcccagct ggctttggac ccctccgggr accagctcat cg #tgggagcc 120 aggaactacc tcttcagact cagccttgcc aatgtctctc ttcttcaggc ca #cagagtgg 180 gcctccagtg aggacacgcg ccgctcctgc caaagcaaag ggaagactga gg #aggagtgt 240 cagaactacg tgcgagtcct gatcgtcgcc ggccggaagg tgttcatgtg tg #gaaccaat 300 gccttttccc ccatgtgcac cagcagacag gtggggaacc tcagccggac ta #ttgagaag 360 atcaatggtg tggcccgctg cccctatgac ccacgccaca actccacagc tg #tcatctcc 420 tcccaggggg agctctatgc agccacggtc atcgacttct caggtcggga cc #ctgccatc 480 taccgcagcc tgggcagtgg gccaccgctt cgcactgccc aatataactc ca #agtggctt 540 aatgagccaa acttcgtggc agcctatgat attgggctgt ttgcatactt ct #tcctgcgg 600 gagaacgcag tggagcacga ctgtggacgc accgtgtact ctcgcgtggc cc #gcgtgtgc 660 aagaatgacg tggggggccg attcctgctg gaggacacat ggaccacatt ca #tgaaggcc 720 cggctcaact gctcccgccc gggcgaggtc cccttctact ataacgagct gc #agagtgcc 780 ttccacttgc crgagcagga cctcatctat ggagttttca caaccaacgt aa #acagcaty 840 gcggcttctg ctgtctgcgc cttcaacctc agtgctatct cccaggcttt ca #atggccca 900 tttcgctacc aggagaaccc cagggctgcc tggctcccca tagccaaccc ca #tccccaat 960 ttccagtgtg gcaccctgcc tgagaccggt cccaacgaga acctgacgga gc #gcagcctg 1020 caggacgcgc agcgcctctt cctgatgagc gaggccgtgc agccggtgac ac #ccgagccc 1080 tgtgtcaccc aggacagcgt gcgcttctca cacctcgtgg tggacctggt gc #aggctaaa 1140 gacacgctct accatgtact ctacattggc accgagtcgg gcaccatcct ga #aggcgctg 1200 tccacggcga gccgcagcct ccacggctgc tacctggagg agctgcacgt gc #tgcccccc 1260 gggcgccgcg agcccctgcg cagcctgcgc atcctgcaca gcgcccgcgc gc #tcttcgtg 1320 gggctgagag acggcgtcct gcgggtccca ctggagaggt gcgccgccta cc #gcagccag 1380 ggggcatgcc tgggggcccg ggacccgtac tgtggctggg acgggaagca gc #aacgttgc 1440 agcacactcg aggacagctc caacatgagc ctctggaccc agaacatcac cg #cctgtcct 1500 gtgcggaatg tgacacggga tgggggcttc ggcccatggt caccatggca ac #catgtgag 1560 cacttggatg gggacaactc aggctcttgc ctgtgtcgag ctcgatcctg tg #attcccct 1620 cgaccccgct gtgggggcct tgactgcctg gggccagcca tccacatcgc ca #actgctcc 1680 aggaatgggg cgtggacccc gtggtcatcg tgggcgctgt gcagcacgtc ct #gtggcatc 1740 ggcttccagg tccgccagcg aagttgcagc aaccctgctc cccgccacgg gg #gccgcatc 1800 tgcgtgggca agagccggga ggaacggttc tgtaatgaga acacgccttg cc #cggtgccc 1860 atcttctggg cttcctgggg ctcctggagc aagtgcagca gcaactgtgg ag #ggggcatg 1920 cagtcgcggc gtcgggcctg cgagaacggc aactcctgcc tgggctgcgg cg #tggagttc 1980 aagacgtgca accccgaggg ctgccccgaa gtgcggcgca acaccccctg ga #cgccgtgg 2040 ctgcccgtga acgtgacgca gggcggggca cggcaggagc agcggttccg ct #tcacctgc 2100 cgcgcgcccc ttgcagaccc gcacggcctg cagttcggca ggagaaggac cg #agacgagg 2160 acctgtcccg cggacggctc cggctcctgc gacaccgacg ccctggtgga gg #acctcctg 2220 cgcagcggga gcacctcccc gcacacggtg agcgggggct gggccgcctg gg #gcccgtgg 2280 tcgtcctgct cccgggactg cgagctgggc ttccgcgtcc gcaagagaac gt #gcactaac 2340 ccggagcccc gcaacggggg cctgccctgc gtgggcgatg ctgccgagta cc #aggactgc 2400 aacccccagg cttgcccagt tcggggtgct tggtcctgct ggacctcatg gt #ctccatgc 2460 tcagcttcct gtggtggggg tcactatcaa cgcacccgtt cctgcaccag cc #ccgcaccc 2520 tccccaggtg aggacatctg tctcgggctg cacacggagg aggcactatg tg #ccacacag 2580 gcctgcccag aaggctggtc gccctggtct gagtggagta agtgcactga cg #acggagcc 2640 cagagccgaa gccggcactg tgaggagctc ctcccagggt ccagcgcctg tg #ctggaaac 2700 agcagccaga gccgcccctg cccctacagc gagattcccg ggttcaatct ca #tccacttg 2760 gtggccacgg gcatctcctg cttcttgggc tctgggctcc tgaccctagc ag #tgtacctg 2820 tcttgccagc actgccagcg tcagtcccag gagtccacac tggtccatcc tg #ccaccccc 2880 aaccatttgc actacaaggg cggaggcacc ccgaagaatg aaaagtacac ac #ccatggaa 2940 ttcaagaccc tgaacaagaa taacttgatc cctgatgaca gagccaactt ct #acccattg 3000 cagcagacca atgtgtacac gactacttac tacccaagcc ccctgaacaa ac #acagcttc 3060 cggcccgagg cctcacctgg acaacggtgc ttccccaaca gctga # 3105 <210> SEQ ID NO 6 <211> LENGTH: 1034 <212> TYPE: PRT <213> ORGANISM: homo sapiens <400> SEQUENCE: 6 Met Thr Val Val Asn Pro Gln Asp Leu Gln Pr #o Trp Val Ser Asn Phe 1 5 # 10 # 15 Thr Tyr Pro Gly Ala Arg Asp Phe Ser Gln Le #u Ala Leu Asp Pro Ser 20 # 25 # 30 Gly Asn Gln Leu Ile Val Gly Ala Arg Asn Ty #r Leu Phe Arg Leu Ser 35 # 40 # 45 Leu Ala Asn Val Ser Leu Leu Gln Ala Thr Gl #u Trp Ala Ser Ser Glu 50 # 55 # 60 Asp Thr Arg Arg Ser Cys Gln Ser Lys Gly Ly #s Thr Glu Glu Glu Cys 65 #70 #75 #80 Gln Asn Tyr Val Arg Val Leu Ile Val Ala Gl #y Arg Lys Val Phe Met 85 # 90 # 95 Cys Gly Thr Asn Ala Phe Ser Pro Met Cys Th #r Ser Arg Gln Val Gly 100 # 105 # 110 Asn Leu Ser Arg Thr Ile Glu Lys Ile Asn Gl #y Val Ala Arg Cys Pro 115 # 120 # 125 Tyr Asp Pro Arg His Asn Ser Thr Ala Val Il #e Ser Ser Gln Gly Glu 130 # 135 # 140 Leu Tyr Ala Ala Thr Val Ile Asp Phe Ser Gl #y Arg Asp Pro Ala Ile 145 1 #50 1 #55 1 #60 Tyr Arg Ser Leu Gly Ser Gly Pro Pro Leu Ar #g Thr Ala Gln Tyr Asn 165 # 170 # 175 Ser Lys Trp Leu Asn Glu Pro Asn Phe Val Al #a Ala Tyr Asp Ile Gly 180 # 185 # 190 Leu Phe Ala Tyr Phe Phe Leu Arg Glu Asn Al #a Val Glu His Asp Cys 195 # 200 # 205 Gly Arg Thr Val Tyr Ser Arg Val Ala Arg Va #l Cys Lys Asn Asp Val 210 # 215 # 220 Gly Gly Arg Phe Leu Leu Glu Asp Thr Trp Th #r Thr Phe Met Lys Ala 225 2 #30 2 #35 2 #40 Arg Leu Asn Cys Ser Arg Pro Gly Glu Val Pr #o Phe Tyr Tyr Asn Glu 245 # 250 # 255 Leu Gln Ser Ala Phe His Leu Pro Glu Gln As #p Leu Ile Tyr Gly Val 260 # 265 # 270 Phe Thr Thr Asn Val Asn Ser Ile Ala Ala Se #r Ala Val Cys Ala Phe 275 # 280 # 285 Asn Leu Ser Ala Ile Ser Gln Ala Phe Asn Gl #y Pro Phe Arg Tyr Gln 290 # 295 # 300 Glu Asn Pro Arg Ala Ala Trp Leu Pro Ile Al #a Asn Pro Ile Pro Asn 305 3 #10 3 #15 3 #20 Phe Gln Cys Gly Thr Leu Pro Glu Thr Gly Pr #o Asn Glu Asn Leu Thr 325 # 330 # 335 Glu Arg Ser Leu Gln Asp Ala Gln Arg Leu Ph #e Leu Met Ser Glu Ala 340 # 345 # 350 Val Gln Pro Val Thr Pro Glu Pro Cys Val Th #r Gln Asp Ser Val Arg 355 # 360 # 365 Phe Ser His Leu Val Val Asp Leu Val Gln Al #a Lys Asp Thr Leu Tyr 370 # 375 # 380 His Val Leu Tyr Ile Gly Thr Glu Ser Gly Th #r Ile Leu Lys Ala Leu 385 3 #90 3 #95 4 #00 Ser Thr Ala Ser Arg Ser Leu His Gly Cys Ty #r Leu Glu Glu Leu His 405 # 410 # 415 Val Leu Pro Pro Gly Arg Arg Glu Pro Leu Ar #g Ser Leu Arg Ile Leu 420 # 425 # 430 His Ser Ala Arg Ala Leu Phe Val Gly Leu Ar #g Asp Gly Val Leu Arg 435 # 440 # 445 Val Pro Leu Glu Arg Cys Ala Ala Tyr Arg Se #r Gln Gly Ala Cys Leu 450 # 455 # 460 Gly Ala Arg Asp Pro Tyr Cys Gly Trp Asp Gl #y Lys Gln Gln Arg Cys 465 4 #70 4 #75 4 #80 Ser Thr Leu Glu Asp Ser Ser Asn Met Ser Le #u Trp Thr Gln Asn Ile 485 # 490 # 495 Thr Ala Cys Pro Val Arg Asn Val Thr Arg As #p Gly Gly Phe Gly Pro 500 # 505 # 510 Trp Ser Pro Trp Gln Pro Cys Glu His Leu As #p Gly Asp Asn Ser Gly 515 # 520 # 525 Ser Cys Leu Cys Arg Ala Arg Ser Cys Asp Se #r Pro Arg Pro Arg Cys 530 # 535 # 540 Gly Gly Leu Asp Cys Leu Gly Pro Ala Ile Hi #s Ile Ala Asn Cys Ser 545 5 #50 5 #55 5 #60 Arg Asn Gly Ala Trp Thr Pro Trp Ser Ser Tr #p Ala Leu Cys Ser Thr 565 # 570 # 575 Ser Cys Gly Ile Gly Phe Gln Val Arg Gln Ar #g Ser Cys Ser Asn Pro 580 # 585 # 590 Ala Pro Arg His Gly Gly Arg Ile Cys Val Gl #y Lys Ser Arg Glu Glu 595 # 600 # 605 Arg Phe Cys Asn Glu Asn Thr Pro Cys Pro Va #l Pro Ile Phe Trp Ala 610 # 615 # 620 Ser Trp Gly Ser Trp Ser Lys Cys Ser Ser As #n Cys Gly Gly Gly Met 625 6 #30 6 #35 6 #40 Gln Ser Arg Arg Arg Ala Cys Glu Asn Gly As #n Ser Cys Leu Gly Cys 645 # 650 # 655 Gly Val Glu Phe Lys Thr Cys Asn Pro Glu Gl #y Cys Pro Glu Val Arg 660 # 665 # 670 Arg Asn Thr Pro Trp Thr Pro Trp Leu Pro Va #l Asn Val Thr Gln Gly 675 # 680 # 685 Gly Ala Arg Gln Glu Gln Arg Phe Arg Phe Th #r Cys Arg Ala Pro Leu 690 # 695 # 700 Ala Asp Pro His Gly Leu Gln Phe Gly Arg Ar #g Arg Thr Glu Thr Arg 705 7 #10 7 #15 7 #20 Thr Cys Pro Ala Asp Gly Ser Gly Ser Cys As #p Thr Asp Ala Leu Val 725 # 730 # 735 Glu Asp Leu Leu Arg Ser Gly Ser Thr Ser Pr #o His Thr Val Ser Gly 740 # 745 # 750 Gly Trp Ala Ala Trp Gly Pro Trp Ser Ser Cy #s Ser Arg Asp Cys Glu 755 # 760 # 765 Leu Gly Phe Arg Val Arg Lys Arg Thr Cys Th #r Asn Pro Glu Pro Arg 770 # 775 # 780 Asn Gly Gly Leu Pro Cys Val Gly Asp Ala Al #a Glu Tyr Gln Asp Cys 785 7 #90 7 #95 8 #00 Asn Pro Gln Ala Cys Pro Val Arg Gly Ala Tr #p Ser Cys Trp Thr Ser 805 # 810 # 815 Trp Ser Pro Cys Ser Ala Ser Cys Gly Gly Gl #y His Tyr Gln Arg Thr 820 # 825 # 830 Arg Ser Cys Thr Ser Pro Ala Pro Ser Pro Gl #y Glu Asp Ile Cys Leu 835 # 840 # 845 Gly Leu His Thr Glu Glu Ala Leu Cys Ala Th #r Gln Ala Cys Pro Glu 850 # 855 # 860 Gly Trp Ser Pro Trp Ser Glu Trp Ser Lys Cy #s Thr Asp Asp Gly Ala 865 8 #70 8 #75 8 #80 Gln Ser Arg Ser Arg His Cys Glu Glu Leu Le #u Pro Gly Ser Ser Ala 885 # 890 # 895 Cys Ala Gly Asn Ser Ser Gln Ser Arg Pro Cy #s Pro Tyr Ser Glu Ile 900 # 905 # 910 Pro Gly Phe Asn Leu Ile His Leu Val Ala Th #r Gly Ile Ser Cys Phe 915 # 920 # 925 Leu Gly Ser Gly Leu Leu Thr Leu Ala Val Ty #r Leu Ser Cys Gln His 930 # 935 # 940 Cys Gln Arg Gln Ser Gln Glu Ser Thr Leu Va #l His Pro Ala Thr Pro 945 9 #50 9 #55 9 #60 Asn His Leu His Tyr Lys Gly Gly Gly Thr Pr #o Lys Asn Glu Lys Tyr 965 # 970 # 975 Thr Pro Met Glu Phe Lys Thr Leu Asn Lys As #n Asn Leu Ile Pro Asp 980 # 985 # 990 Asp Arg Ala Asn Phe Tyr Pro Leu Gln Gln Th #r Asn Val Tyr Thr Thr 995 # 1000 # 1005 Thr Tyr Tyr Pro Ser Pro Leu Asn Lys His Se #r Phe Arg Pro Glu Ala 1010 # 1015 # 1020 Ser Pro Gly Gln Arg Cys Phe Pro Asn Ser 1025 1030 <210> SEQ ID NO 7 <211> LENGTH: 3237 <212> TYPE: DNA <213> ORGANISM: homo sapiens <400> SEQUENCE: 7 atggtgcttg caggccccct ggctgtctcg ctgttgctgc ccagcctcac ac #tgctggtg 60 tcccacctct ccagctccca ggatgtctcc agtgagccca gcagtgagca gc #agctgtgc 120 gcccttagca agcaccccac cgtggccttt gaagacctgc agccgtgggt ct #ctaacttc 180 acctaccctg gagcccggga tttctcccag ctggctttgg acccctccgg gr #accagctc 240 atcgtgggag ccaggaacta cctcttcaga ctcagccttg ccaatgtctc tc #ttcttcag 300 gccacagagt gggcctccag tgaggacacg cgccgctcct gccaaagcaa ag #ggaagact 360 gaggaggagt gtcagaacta cgtgcgagtc ctgatcgtcg ccggccggaa gg #tgttcatg 420 tgtggaacca atgccttttc ccccatgtgc accagcagac aggtggggaa cc #tcagccgg 480 actattgaga agatcaatgg tgtggcccgc tgcccctatg acccacgcca ca #actccaca 540 gctgtcatct cctcccaggg ggagctctat gcagccacgg tcatcgactt ct #caggtcgg 600 gaccctgcca tctaccgcag cctgggcagt gggccaccgc ttcgcactgc cc #aatataac 660 tccaagtggc ttaatgagcc aaacttcgtg gcagcctatg atattgggct gt #ttgcatac 720 ttcttcctgc gggagaacgc agtggagcac gactgtggac gcaccgtgta ct #ctcgcgtg 780 gcccgcgtgt gcaagaatga cgtggggggc cgattcctgc tggaggacac at #ggaccaca 840 ttcatgaagg cccggctcaa ctgctcccgc ccgggcgagg tccccttcta ct #ataacgag 900 ctgcagagtg ccttccactt gccrgagcag gacctcatct atggagtttt ca #caaccaac 960 gtaaacagca tygcggcttc tgctgtctgc gccttcaacc tcagtgctat ct #cccaggct 1020 ttcaatggcc catttcgcta ccaggagaac cccagggctg cctggctccc ca #tagccaac 1080 cccatcccca atttccagtg tggcaccctg cctgagaccg gtcccaacga ga #acctgacg 1140 gagcgcagcc tgcaggacgc gcagcgcctc ttcctgatga gcgaggccgt gc #agccggtg 1200 acacccgagc cctgtgtcac ccaggacagc gtgcgcttct cacacctcgt gg #tggacctg 1260 gtgcaggcta aagacacgct ctaccatgta ctctacattg gcaccgagtc gg #gcaccatc 1320 ctgaaggcgc tgtccacggc gagccgcagc ctccacggct gctacctgga gg #agctgcac 1380 gtgctgcccc ccgggcgccg cgagcccctg cgcagcctgc gcatcctgca ca #gcgcccgc 1440 gcgctcttcg tggggctgag agacggcgtc ctgcgggtcc cactggagag gt #gcgccgcc 1500 taccgcagcc agggggcatg cctgggggcc cgggacccgt actgtggctg gg #acgggaag 1560 cagcaacgtt gcagcacact cgaggacagc tccaacatga gcctctggac cc #agaacatc 1620 accgcctgtc ctgtgcggaa tgtgacacgg gatgggggct tcggcccatg gt #caccatgg 1680 caaccatgtg agcacttgga tggggacaac tcaggctctt gcctgtgtcg ag #ctcgatcc 1740 tgtgattccc ctcgaccccg ctgtgggggc cttgactgcc tggggccagc ca #tccacatc 1800 gccaactgct ccaggaatgg ggcgtggacc ccgtggtcat cgtgggcgct gt #gcagcacg 1860 tcctgtggca tcggcttcca ggtccgccag cgaagttgca gcaaccctgc tc #cccgccac 1920 gggggccgca tctgcgtggg caagagccgg gaggaacggt tctgtaatga ga #acacgcct 1980 tgcccggtgc ccatcttctg ggcttcctgg ggctcctgga gcaagtgcag ca #gcaactgt 2040 ggagggggca tgcagtcgcg gcgtcgggcc tgcgagaacg gcaactcctg cc #tgggctgc 2100 ggcgtggagt tcaagacgtg caaccccgag ggctgccccg aagtgcggcg ca #acaccccc 2160 tggacgccgt ggctgcccgt gaacgtgacg cagggcgggg cacggcagga gc #agcggttc 2220 cgcttcacct gccgcgcgcc ccttgcagac ccgcacggcc tgcagttcgg ca #ggagaagg 2280 accgagacga ggacctgtcc cgcggacggc tccggctcct gcgacaccga cg #ccctggtg 2340 gaggacctcc tgcgcagcgg gagcacctcc ccgcacacgg tgagcggggg ct #gggccgcc 2400 tggggcccgt ggtcgtcctg ctcccgggac tgcgagctgg gcttccgcgt cc #gcaagaga 2460 acgtgcacta acccggagcc ccgcaacggg ggcctgccct gcgtgggcga tg #ctgccgag 2520 taccaggact gcaaccccca ggcttgccca gttcggggtg cttggtcctg ct #ggacctca 2580 tggtctccat gctcagcttc ctgtggtggg ggtcactatc aacgcacccg tt #cctgcacc 2640 agccccgcac cctccccagg tgaggacatc tgtctcgggc tgcacacgga gg #aggcacta 2700 tgtgccacac aggcctgccc agaaggctgg tcgccctggt ctgagtggag ta #agtgcact 2760 gacgacggag cccagagccg aagccggcac tgtgaggagc tcctcccagg gt #ccagcgcc 2820 tgtgctggaa acagcagcca gagccgcccc tgcccctaca gcgagattcc cg #ggttcaat 2880 ctcatccact tggtggccac gggcatctcc tgcttcttgg gctctgggct cc #tgacccta 2940 gcagtgtacc tgtcttgcca gcactgccag cgtcagtccc aggagtccac ac #tggtccat 3000 cctgccaccc ccaaccattt gcactacaag ggcggaggca ccccgaagaa tg #aaaagtac 3060 acacccatgg aattcaagac cctgaacaag aataacttga tccctgatga ca #gagccaac 3120 ttctacccat tgcagcagac caatgtgtac acgactactt actacccaag cc #ccctgaac 3180 aaacacagct tccggcccga ggcctcacct ggacaacggt gcttccccaa ca #gctga 3237 <210> SEQ ID NO 8 <211> LENGTH: 1078 <212> TYPE: PRT <213> ORGANISM: homo sapiens <400> SEQUENCE: 8 Met Val Leu Ala Gly Pro Leu Ala Val Ser Le #u Leu Leu Pro Ser Leu 1 5 # 10 # 15 Thr Leu Leu Val Ser His Leu Ser Ser Ser Gl #n Asp Val Ser Ser Glu 20 # 25 # 30 Pro Ser Ser Glu Gln Gln Leu Cys Ala Leu Se #r Lys His Pro Thr Val 35 # 40 # 45 Ala Phe Glu Asp Leu Gln Pro Trp Val Ser As #n Phe Thr Tyr Pro Gly 50 # 55 # 60 Ala Arg Asp Phe Ser Gln Leu Ala Leu Asp Pr #o Ser Gly Asn Gln Leu 65 #70 #75 #80 Ile Val Gly Ala Arg Asn Tyr Leu Phe Arg Le #u Ser Leu Ala Asn Val 85 # 90 # 95 Ser Leu Leu Gln Ala Thr Glu Trp Ala Ser Se #r Glu Asp Thr Arg Arg 100 # 105 # 110 Ser Cys Gln Ser Lys Gly Lys Thr Glu Glu Gl #u Cys Gln Asn Tyr Val 115 # 120 # 125 Arg Val Leu Ile Val Ala Gly Arg Lys Val Ph #e Met Cys Gly Thr Asn 130 # 135 # 140 Ala Phe Ser Pro Met Cys Thr Ser Arg Gln Va #l Gly Asn Leu Ser Arg 145 1 #50 1 #55 1 #60 Thr Ile Glu Lys Ile Asn Gly Val Ala Arg Cy #s Pro Tyr Asp Pro Arg 165 # 170 # 175 His Asn Ser Thr Ala Val Ile Ser Ser Gln Gl #y Glu Leu Tyr Ala Ala 180 # 185 # 190 Thr Val Ile Asp Phe Ser Gly Arg Asp Pro Al #a Ile Tyr Arg Ser Leu 195 # 200 # 205 Gly Ser Gly Pro Pro Leu Arg Thr Ala Gln Ty #r Asn Ser Lys Trp Leu 210 # 215 # 220 Asn Glu Pro Asn Phe Val Ala Ala Tyr Asp Il #e Gly Leu Phe Ala Tyr 225 2 #30 2 #35 2 #40 Phe Phe Leu Arg Glu Asn Ala Val Glu His As #p Cys Gly Arg Thr Val 245 # 250 # 255 Tyr Ser Arg Val Ala Arg Val Cys Lys Asn As #p Val Gly Gly Arg Phe 260 # 265 # 270 Leu Leu Glu Asp Thr Trp Thr Thr Phe Met Ly #s Ala Arg Leu Asn Cys 275 # 280 # 285 Ser Arg Pro Gly Glu Val Pro Phe Tyr Tyr As #n Glu Leu Gln Ser Ala 290 # 295 # 300 Phe His Leu Pro Glu Gln Asp Leu Ile Tyr Gl #y Val Phe Thr Thr Asn 305 3 #10 3 #15 3 #20 Val Asn Ser Ile Ala Ala Ser Ala Val Cys Al #a Phe Asn Leu Ser Ala 325 # 330 # 335 Ile Ser Gln Ala Phe Asn Gly Pro Phe Arg Ty #r Gln Glu Asn Pro Arg 340 # 345 # 350 Ala Ala Trp Leu Pro Ile Ala Asn Pro Ile Pr #o Asn Phe Gln Cys Gly 355 # 360 # 365 Thr Leu Pro Glu Thr Gly Pro Asn Glu Asn Le #u Thr Glu Arg Ser Leu 370 # 375 # 380 Gln Asp Ala Gln Arg Leu Phe Leu Met Ser Gl #u Ala Val Gln Pro Val 385 3 #90 3 #95 4 #00 Thr Pro Glu Pro Cys Val Thr Gln Asp Ser Va #l Arg Phe Ser His Leu 405 # 410 # 415 Val Val Asp Leu Val Gln Ala Lys Asp Thr Le #u Tyr His Val Leu Tyr 420 # 425 # 430 Ile Gly Thr Glu Ser Gly Thr Ile Leu Lys Al #a Leu Ser Thr Ala Ser 435 # 440 # 445 Arg Ser Leu His Gly Cys Tyr Leu Glu Glu Le #u His Val Leu Pro Pro 450 # 455 # 460 Gly Arg Arg Glu Pro Leu Arg Ser Leu Arg Il #e Leu His Ser Ala Arg 465 4 #70 4 #75 4 #80 Ala Leu Phe Val Gly Leu Arg Asp Gly Val Le #u Arg Val Pro Leu Glu 485 # 490 # 495 Arg Cys Ala Ala Tyr Arg Ser Gln Gly Ala Cy #s Leu Gly Ala Arg Asp 500 # 505 # 510 Pro Tyr Cys Gly Trp Asp Gly Lys Gln Gln Ar #g Cys Ser Thr Leu Glu 515 # 520 # 525 Asp Ser Ser Asn Met Ser Leu Trp Thr Gln As #n Ile Thr Ala Cys Pro 530 # 535 # 540 Val Arg Asn Val Thr Arg Asp Gly Gly Phe Gl #y Pro Trp Ser Pro Trp 545 5 #50 5 #55 5 #60 Gln Pro Cys Glu His Leu Asp Gly Asp Asn Se #r Gly Ser Cys Leu Cys 565 # 570 # 575 Arg Ala Arg Ser Cys Asp Ser Pro Arg Pro Ar #g Cys Gly Gly Leu Asp 580 # 585 # 590 Cys Leu Gly Pro Ala Ile His Ile Ala Asn Cy #s Ser Arg Asn Gly Ala 595 # 600 # 605 Trp Thr Pro Trp Ser Ser Trp Ala Leu Cys Se #r Thr Ser Cys Gly Ile 610 # 615 # 620 Gly Phe Gln Val Arg Gln Arg Ser Cys Ser As #n Pro Ala Pro Arg His 625 6 #30 6 #35 6 #40 Gly Gly Arg Ile Cys Val Gly Lys Ser Arg Gl #u Glu Arg Phe Cys Asn 645 # 650 # 655 Glu Asn Thr Pro Cys Pro Val Pro Ile Phe Tr #p Ala Ser Trp Gly Ser 660 # 665 # 670 Trp Ser Lys Cys Ser Ser Asn Cys Gly Gly Gl #y Met Gln Ser Arg Arg 675 # 680 # 685 Arg Ala Cys Glu Asn Gly Asn Ser Cys Leu Gl #y Cys Gly Val Glu Phe 690 # 695 # 700 Lys Thr Cys Asn Pro Glu Gly Cys Pro Glu Va #l Arg Arg Asn Thr Pro 705 7 #10 7 #15 7 #20 Trp Thr Pro Trp Leu Pro Val Asn Val Thr Gl #n Gly Gly Ala Arg Gln 725 # 730 # 735 Glu Gln Arg Phe Arg Phe Thr Cys Arg Ala Pr #o Leu Ala Asp Pro His 740 # 745 # 750 Gly Leu Gln Phe Gly Arg Arg Arg Thr Glu Th #r Arg Thr Cys Pro Ala 755 # 760 # 765 Asp Gly Ser Gly Ser Cys Asp Thr Asp Ala Le #u Val Glu Asp Leu Leu 770 # 775 # 780 Arg Ser Gly Ser Thr Ser Pro His Thr Val Se #r Gly Gly Trp Ala Ala 785 7 #90 7 #95 8 #00 Trp Gly Pro Trp Ser Ser Cys Ser Arg Asp Cy #s Glu Leu Gly Phe Arg 805 # 810 # 815 Val Arg Lys Arg Thr Cys Thr Asn Pro Glu Pr #o Arg Asn Gly Gly Leu 820 # 825 # 830 Pro Cys Val Gly Asp Ala Ala Glu Tyr Gln As #p Cys Asn Pro Gln Ala 835 # 840 # 845 Cys Pro Val Arg Gly Ala Trp Ser Cys Trp Th #r Ser Trp Ser Pro Cys 850 # 855 # 860 Ser Ala Ser Cys Gly Gly Gly His Tyr Gln Ar #g Thr Arg Ser Cys Thr 865 8 #70 8 #75 8 #80 Ser Pro Ala Pro Ser Pro Gly Glu Asp Ile Cy #s Leu Gly Leu His Thr 885 # 890 # 895 Glu Glu Ala Leu Cys Ala Thr Gln Ala Cys Pr #o Glu Gly Trp Ser Pro 900 # 905 # 910 Trp Ser Glu Trp Ser Lys Cys Thr Asp Asp Gl #y Ala Gln Ser Arg Ser 915 # 920 # 925 Arg His Cys Glu Glu Leu Leu Pro Gly Ser Se #r Ala Cys Ala Gly Asn 930 # 935 # 940 Ser Ser Gln Ser Arg Pro Cys Pro Tyr Ser Gl #u Ile Pro Gly Phe Asn 945 9 #50 9 #55 9 #60 Leu Ile His Leu Val Ala Thr Gly Ile Ser Cy #s Phe Leu Gly Ser Gly 965 # 970 # 975 Leu Leu Thr Leu Ala Val Tyr Leu Ser Cys Gl #n His Cys Gln Arg Gln 980 # 985 # 990 Ser Gln Glu Ser Thr Leu Val His Pro Ala Th #r Pro Asn His Leu His 995 # 1000 # 1005 Tyr Lys Gly Gly Gly Thr Pro Lys Asn Glu Ly #s Tyr Thr Pro Met Glu 1010 # 1015 # 1020 Phe Lys Thr Leu Asn Lys Asn Asn Leu Ile Pr #o Asp Asp Arg Ala Asn 1025 1030 # 1035 # 1040 Phe Tyr Pro Leu Gln Gln Thr Asn Val Tyr Th #r Thr Thr Tyr Tyr Pro 1045 # 1050 # 1055 Ser Pro Leu Asn Lys His Ser Phe Arg Pro Gl #u Ala Ser Pro Gly Gln 1060 # 1065 # 1070 Arg Cys Phe Pro Asn Ser 1075 <210> SEQ ID NO 9 <211> LENGTH: 3456 <212> TYPE: DNA <213> ORGANISM: homo sapiens <400> SEQUENCE: 9 atgccctgtg gcttcagtcc gtctcctgtt gcccaccacc tcgtccctgg gc #cgcctgat 60 accccagccc aacagctaag gtgtggatgg acagtagggg gctggcttct ct #cactggtc 120 aggggtcttc tcccctgtct gcctcccgga gctaggactg cagaggggcc ta #tcatggtg 180 cttgcaggcc ccctggctgt ctcgctgttg ctgcccagcc tcacactgct gg #tgtcccac 240 ctctccagct cccaggatgt ctccagtgag cccagcagtg agcagcagct gt #gcgccctt 300 agcaagcacc ccaccgtggc ctttgaagac ctgcagccgt gggtctctaa ct #tcacctac 360 cctggagccc gggatttctc ccagctggct ttggacccct ccgggracca gc #tcatcgtg 420 ggagccagga actacctctt cagactcagc cttgccaatg tctctcttct tc #aggccaca 480 gagtgggcct ccagtgagga cacgcgccgc tcctgccaaa gcaaagggaa ga #ctgaggag 540 gagtgtcaga actacgtgcg agtcctgatc gtcgccggcc ggaaggtgtt ca #tgtgtgga 600 accaatgcct tttcccccat gtgcaccagc agacaggtgg ggaacctcag cc #ggactatt 660 gagaagatca atggtgtggc ccgctgcccc tatgacccac gccacaactc ca #cagctgtc 720 atctcctccc agggggagct ctatgcagcc acggtcatcg acttctcagg tc #gggaccct 780 gccatctacc gcagcctggg cagtgggcca ccgcttcgca ctgcccaata ta #actccaag 840 tggcttaatg agccaaactt cgtggcagcc tatgatattg ggctgtttgc at #acttcttc 900 ctgcgggaga acgcagtgga gcacgactgt ggacgcaccg tgtactctcg cg #tggcccgc 960 gtgtgcaaga atgacgtggg gggccgattc ctgctggagg acacatggac ca #cattcatg 1020 aaggcccggc tcaactgctc ccgcccgggc gaggtcccct tctactataa cg #agctgcag 1080 agtgccttcc acttgccrga gcaggacctc atctatggag ttttcacaac ca #acgtaaac 1140 agcatygcgg cttctgctgt ctgcgccttc aacctcagtg ctatctccca gg #ctttcaat 1200 ggcccatttc gctaccagga gaaccccagg gctgcctggc tccccatagc ca #accccatc 1260 cccaatttcc agtgtggcac cctgcctgag accggtccca acgagaacct ga #cggagcgc 1320 agcctgcagg acgcgcagcg cctcttcctg atgagcgagg ccgtgcagcc gg #tgacaccc 1380 gagccctgtg tcacccagga cagcgtgcgc ttctcacacc tcgtggtgga cc #tggtgcag 1440 gctaaagaca cgctctacca tgtactctac attggcaccg agtcgggcac ca #tcctgaag 1500 gcgctgtcca cggcgagccg cagcctccac ggctgctacc tggaggagct gc #acgtgctg 1560 ccccccgggc gccgcgagcc cctgcgcagc ctgcgcatcc tgcacagcgc cc #gcgcgctc 1620 ttcgtggggc tgagagacgg cgtcctgcgg gtcccactgg agaggtgcgc cg #cctaccgc 1680 agccaggggg catgcctggg ggcccgggac ccgtactgtg gctgggacgg ga #agcagcaa 1740 cgttgcagca cactcgagga cagctccaac atgagcctct ggacccagaa ca #tcaccgcc 1800 tgtcctgtgc ggaatgtgac acgggatggg ggcttcggcc catggtcacc at #ggcaacca 1860 tgtgagcact tggatgggga caactcaggc tcttgcctgt gtcgagctcg at #cctgtgat 1920 tcccctcgac cccgctgtgg gggccttgac tgcctggggc cagccatcca ca #tcgccaac 1980 tgctccagga atggggcgtg gaccccgtgg tcatcgtggg cgctgtgcag ca #cgtcctgt 2040 ggcatcggct tccaggtccg ccagcgaagt tgcagcaacc ctgctccccg cc #acgggggc 2100 cgcatctgcg tgggcaagag ccgggaggaa cggttctgta atgagaacac gc #cttgcccg 2160 gtgcccatct tctgggcttc ctggggctcc tggagcaagt gcagcagcaa ct #gtggaggg 2220 ggcatgcagt cgcggcgtcg ggcctgcgag aacggcaact cctgcctggg ct #gcggcgtg 2280 gagttcaaga cgtgcaaccc cgagggctgc cccgaagtgc ggcgcaacac cc #cctggacg 2340 ccgtggctgc ccgtgaacgt gacgcagggc ggggcacggc aggagcagcg gt #tccgcttc 2400 acctgccgcg cgccccttgc agacccgcac ggcctgcagt tcggcaggag aa #ggaccgag 2460 acgaggacct gtcccgcgga cggctccggc tcctgcgaca ccgacgccct gg #tggaggac 2520 ctcctgcgca gcgggagcac ctccccgcac acggtgagcg ggggctgggc cg #cctggggc 2580 ccgtggtcgt cctgctcccg ggactgcgag ctgggcttcc gcgtccgcaa ga #gaacgtgc 2640 actaacccgg agccccgcaa cgggggcctg ccctgcgtgg gcgatgctgc cg #agtaccag 2700 gactgcaacc cccaggcttg cccagttcgg ggtgcttggt cctgctggac ct #catggtct 2760 ccatgctcag cttcctgtgg tgggggtcac tatcaacgca cccgttcctg ca #ccagcccc 2820 gcaccctccc caggtgagga catctgtctc gggctgcaca cggaggaggc ac #tatgtgcc 2880 acacaggcct gcccagaagg ctggtcgccc tggtctgagt ggagtaagtg ca #ctgacgac 2940 ggagcccaga gccgaagccg gcactgtgag gagctcctcc cagggtccag cg #cctgtgct 3000 ggaaacagca gccagagccg cccctgcccc tacagcgaga ttcccgtcat cc #tgccagcc 3060 tccagcatgg aggaggccac cggctgtgca gggttcaatc tcatccactt gg #tggccacg 3120 ggcatctcct gcttcttggg ctctgggctc ctgaccctag cagtgtacct gt #cttgccag 3180 cactgccagc gtcagtccca ggagtccaca ctggtccatc ctgccacccc ca #accatttg 3240 cactacaagg gcggaggcac cccgaagaat gaaaagtaca cacccatgga at #tcaagacc 3300 ctgaacaaga ataacttgat ccctgatgac agagccaact tctacccatt gc #agcagacc 3360 aatgtgtaca cgactactta ctacccaagc cccctgaaca aacacagctt cc #ggcccgag 3420 gcctcacctg gacaacggtg cttccccaac agctga # # 3456 <210> SEQ ID NO 10 <211> LENGTH: 1151 <212> TYPE: PRT <213> ORGANISM: homo sapiens <400> SEQUENCE: 10 Met Pro Cys Gly Phe Ser Pro Ser Pro Val Al #a His His Leu Val Pro 1 5 # 10 # 15 Gly Pro Pro Asp Thr Pro Ala Gln Gln Leu Ar #g Cys Gly Trp Thr Val 20 # 25 # 30 Gly Gly Trp Leu Leu Ser Leu Val Arg Gly Le #u Leu Pro Cys Leu Pro 35 # 40 # 45 Pro Gly Ala Arg Thr Ala Glu Gly Pro Ile Me #t Val Leu Ala Gly Pro 50 # 55 # 60 Leu Ala Val Ser Leu Leu Leu Pro Ser Leu Th #r Leu Leu Val Ser His 65 #70 #75 #80 Leu Ser Ser Ser Gln Asp Val Ser Ser Glu Pr #o Ser Ser Glu Gln Gln 85 # 90 # 95 Leu Cys Ala Leu Ser Lys His Pro Thr Val Al #a Phe Glu Asp Leu Gln 100 # 105 # 110 Pro Trp Val Ser Asn Phe Thr Tyr Pro Gly Al #a Arg Asp Phe Ser Gln 115 # 120 # 125 Leu Ala Leu Asp Pro Ser Gly Asn Gln Leu Il #e Val Gly Ala Arg Asn 130 # 135 # 140 Tyr Leu Phe Arg Leu Ser Leu Ala Asn Val Se #r Leu Leu Gln Ala Thr 145 1 #50 1 #55 1 #60 Glu Trp Ala Ser Ser Glu Asp Thr Arg Arg Se #r Cys Gln Ser Lys Gly 165 # 170 # 175 Lys Thr Glu Glu Glu Cys Gln Asn Tyr Val Ar #g Val Leu Ile Val Ala 180 # 185 # 190 Gly Arg Lys Val Phe Met Cys Gly Thr Asn Al #a Phe Ser Pro Met Cys 195 # 200 # 205 Thr Ser Arg Gln Val Gly Asn Leu Ser Arg Th #r Ile Glu Lys Ile Asn 210 # 215 # 220 Gly Val Ala Arg Cys Pro Tyr Asp Pro Arg Hi #s Asn Ser Thr Ala Val 225 2 #30 2 #35 2 #40 Ile Ser Ser Gln Gly Glu Leu Tyr Ala Ala Th #r Val Ile Asp Phe Ser 245 # 250 # 255 Gly Arg Asp Pro Ala Ile Tyr Arg Ser Leu Gl #y Ser Gly Pro Pro Leu 260 # 265 # 270 Arg Thr Ala Gln Tyr Asn Ser Lys Trp Leu As #n Glu Pro Asn Phe Val 275 # 280 # 285 Ala Ala Tyr Asp Ile Gly Leu Phe Ala Tyr Ph #e Phe Leu Arg Glu Asn 290 # 295 # 300 Ala Val Glu His Asp Cys Gly Arg Thr Val Ty #r Ser Arg Val Ala Arg 305 3 #10 3 #15 3 #20 Val Cys Lys Asn Asp Val Gly Gly Arg Phe Le #u Leu Glu Asp Thr Trp 325 # 330 # 335 Thr Thr Phe Met Lys Ala Arg Leu Asn Cys Se #r Arg Pro Gly Glu Val 340 # 345 # 350 Pro Phe Tyr Tyr Asn Glu Leu Gln Ser Ala Ph #e His Leu Pro Glu Gln 355 # 360 # 365 Asp Leu Ile Tyr Gly Val Phe Thr Thr Asn Va #l Asn Ser Ile Ala Ala 370 # 375 # 380 Ser Ala Val Cys Ala Phe Asn Leu Ser Ala Il #e Ser Gln Ala Phe Asn 385 3 #90 3 #95 4 #00 Gly Pro Phe Arg Tyr Gln Glu Asn Pro Arg Al #a Ala Trp Leu Pro Ile 405 # 410 # 415 Ala Asn Pro Ile Pro Asn Phe Gln Cys Gly Th #r Leu Pro Glu Thr Gly 420 # 425 # 430 Pro Asn Glu Asn Leu Thr Glu Arg Ser Leu Gl #n Asp Ala Gln Arg Leu 435 # 440 # 445 Phe Leu Met Ser Glu Ala Val Gln Pro Val Th #r Pro Glu Pro Cys Val 450 # 455 # 460 Thr Gln Asp Ser Val Arg Phe Ser His Leu Va #l Val Asp Leu Val Gln 465 4 #70 4 #75 4 #80 Ala Lys Asp Thr Leu Tyr His Val Leu Tyr Il #e Gly Thr Glu Ser Gly 485 # 490 # 495 Thr Ile Leu Lys Ala Leu Ser Thr Ala Ser Ar #g Ser Leu His Gly Cys 500 # 505 # 510 Tyr Leu Glu Glu Leu His Val Leu Pro Pro Gl #y Arg Arg Glu Pro Leu 515 # 520 # 525 Arg Ser Leu Arg Ile Leu His Ser Ala Arg Al #a Leu Phe Val Gly Leu 530 # 535 # 540 Arg Asp Gly Val Leu Arg Val Pro Leu Glu Ar #g Cys Ala Ala Tyr Arg 545 5 #50 5 #55 5 #60 Ser Gln Gly Ala Cys Leu Gly Ala Arg Asp Pr #o Tyr Cys Gly Trp Asp 565 # 570 # 575 Gly Lys Gln Gln Arg Cys Ser Thr Leu Glu As #p Ser Ser Asn Met Ser 580 # 585 # 590 Leu Trp Thr Gln Asn Ile Thr Ala Cys Pro Va #l Arg Asn Val Thr Arg 595 # 600 # 605 Asp Gly Gly Phe Gly Pro Trp Ser Pro Trp Gl #n Pro Cys Glu His Leu 610 # 615 # 620 Asp Gly Asp Asn Ser Gly Ser Cys Leu Cys Ar #g Ala Arg Ser Cys Asp 625 6 #30 6 #35 6 #40 Ser Pro Arg Pro Arg Cys Gly Gly Leu Asp Cy #s Leu Gly Pro Ala Ile 645 # 650 # 655 His Ile Ala Asn Cys Ser Arg Asn Gly Ala Tr #p Thr Pro Trp Ser Ser 660 # 665 # 670 Trp Ala Leu Cys Ser Thr Ser Cys Gly Ile Gl #y Phe Gln Val Arg Gln 675 # 680 # 685 Arg Ser Cys Ser Asn Pro Ala Pro Arg His Gl #y Gly Arg Ile Cys Val 690 # 695 # 700 Gly Lys Ser Arg Glu Glu Arg Phe Cys Asn Gl #u Asn Thr Pro Cys Pro 705 7 #10 7 #15 7 #20 Val Pro Ile Phe Trp Ala Ser Trp Gly Ser Tr #p Ser Lys Cys Ser Ser 725 # 730 # 735 Asn Cys Gly Gly Gly Met Gln Ser Arg Arg Ar #g Ala Cys Glu Asn Gly 740 # 745 # 750 Asn Ser Cys Leu Gly Cys Gly Val Glu Phe Ly #s Thr Cys Asn Pro Glu 755 # 760 # 765 Gly Cys Pro Glu Val Arg Arg Asn Thr Pro Tr #p Thr Pro Trp Leu Pro 770 # 775 # 780 Val Asn Val Thr Gln Gly Gly Ala Arg Gln Gl #u Gln Arg Phe Arg Phe 785 7 #90 7 #95 8 #00 Thr Cys Arg Ala Pro Leu Ala Asp Pro His Gl #y Leu Gln Phe Gly Arg 805 # 810 # 815 Arg Arg Thr Glu Thr Arg Thr Cys Pro Ala As #p Gly Ser Gly Ser Cys 820 # 825 # 830 Asp Thr Asp Ala Leu Val Glu Asp Leu Leu Ar #g Ser Gly Ser Thr Ser 835 # 840 # 845 Pro His Thr Val Ser Gly Gly Trp Ala Ala Tr #p Gly Pro Trp Ser Ser 850 # 855 # 860 Cys Ser Arg Asp Cys Glu Leu Gly Phe Arg Va #l Arg Lys Arg Thr Cys 865 8 #70 8 #75 8 #80 Thr Asn Pro Glu Pro Arg Asn Gly Gly Leu Pr #o Cys Val Gly Asp Ala 885 # 890 # 895 Ala Glu Tyr Gln Asp Cys Asn Pro Gln Ala Cy #s Pro Val Arg Gly Ala 900 # 905 # 910 Trp Ser Cys Trp Thr Ser Trp Ser Pro Cys Se #r Ala Ser Cys Gly Gly 915 # 920 # 925 Gly His Tyr Gln Arg Thr Arg Ser Cys Thr Se #r Pro Ala Pro Ser Pro 930 # 935 # 940 Gly Glu Asp Ile Cys Leu Gly Leu His Thr Gl #u Glu Ala Leu Cys Ala 945 9 #50 9 #55 9 #60 Thr Gln Ala Cys Pro Glu Gly Trp Ser Pro Tr #p Ser Glu Trp Ser Lys 965 # 970 # 975 Cys Thr Asp Asp Gly Ala Gln Ser Arg Ser Ar #g His Cys Glu Glu Leu 980 # 985 # 990 Leu Pro Gly Ser Ser Ala Cys Ala Gly Asn Se #r Ser Gln Ser Arg Pro 995 # 1000 # 1005 Cys Pro Tyr Ser Glu Ile Pro Val Ile Leu Pr #o Ala Ser Ser Met Glu 1010 # 1015 # 1020 Glu Ala Thr Gly Cys Ala Gly Phe Asn Leu Il #e His Leu Val Ala Thr 1025 1030 # 1035 # 1040 Gly Ile Ser Cys Phe Leu Gly Ser Gly Leu Le #u Thr Leu Ala Val Tyr 1045 # 1050 # 1055 Leu Ser Cys Gln His Cys Gln Arg Gln Ser Gl #n Glu Ser Thr Leu Val 1060 # 1065 # 1070 His Pro Ala Thr Pro Asn His Leu His Tyr Ly #s Gly Gly Gly Thr Pro 1075 # 1080 # 1085 Lys Asn Glu Lys Tyr Thr Pro Met Glu Phe Ly #s Thr Leu Asn Lys Asn 1090 # 1095 # 1100 Asn Leu Ile Pro Asp Asp Arg Ala Asn Phe Ty #r Pro Leu Gln Gln Thr 1105 1110 # 1115 # 1120 Asn Val Tyr Thr Thr Thr Tyr Tyr Pro Ser Pr #o Leu Asn Lys His Ser 1125 # 1130 # 1135 Phe Arg Pro Glu Ala Ser Pro Gly Gln Arg Cy #s Phe Pro Asn Ser 1140 # 1145 # 1150 <210> SEQ ID NO 11 <211> LENGTH: 3411 <212> TYPE: DNA <213> ORGANISM: homo sapiens <400> SEQUENCE: 11 atgccctgtg gcttcagtcc gtctcctgtt gcccaccacc tcgtccctgg gc #cgcctgat 60 accccagccc aacagctaag gtgtggatgg acagtagggg gctggcttct ct #cactggtc 120 aggggtcttc tcccctgtct gcctcccgga gctaggactg cagaggggcc ta #tcatggtg 180 cttgcaggcc ccctggctgt ctcgctgttg ctgcccagcc tcacactgct gg #tgtcccac 240 ctctccagct cccaggatgt ctccagtgag cccagcagtg agcagcagct gt #gcgccctt 300 agcaagcacc ccaccgtggc ctttgaagac ctgcagccgt gggtctctaa ct #tcacctac 360 cctggagccc gggatttctc ccagctggct ttggacccct ccgggracca gc #tcatcgtg 420 ggagccagga actacctctt cagactcagc cttgccaatg tctctcttct tc #aggccaca 480 gagtgggcct ccagtgagga cacgcgccgc tcctgccaaa gcaaagggaa ga #ctgaggag 540 gagtgtcaga actacgtgcg agtcctgatc gtcgccggcc ggaaggtgtt ca #tgtgtgga 600 accaatgcct tttcccccat gtgcaccagc agacaggtgg ggaacctcag cc #ggactatt 660 gagaagatca atggtgtggc ccgctgcccc tatgacccac gccacaactc ca #cagctgtc 720 atctcctccc agggggagct ctatgcagcc acggtcatcg acttctcagg tc #gggaccct 780 gccatctacc gcagcctggg cagtgggcca ccgcttcgca ctgcccaata ta #actccaag 840 tggcttaatg agccaaactt cgtggcagcc tatgatattg ggctgtttgc at #acttcttc 900 ctgcgggaga acgcagtgga gcacgactgt ggacgcaccg tgtactctcg cg #tggcccgc 960 gtgtgcaaga atgacgtggg gggccgattc ctgctggagg acacatggac ca #cattcatg 1020 aaggcccggc tcaactgctc ccgcccgggc gaggtcccct tctactataa cg #agctgcag 1080 agtgccttcc acttgccrga gcaggacctc atctatggag ttttcacaac ca #acgtaaac 1140 agcatygcgg cttctgctgt ctgcgccttc aacctcagtg ctatctccca gg #ctttcaat 1200 ggcccatttc gctaccagga gaaccccagg gctgcctggc tccccatagc ca #accccatc 1260 cccaatttcc agtgtggcac cctgcctgag accggtccca acgagaacct ga #cggagcgc 1320 agcctgcagg acgcgcagcg cctcttcctg atgagcgagg ccgtgcagcc gg #tgacaccc 1380 gagccctgtg tcacccagga cagcgtgcgc ttctcacacc tcgtggtgga cc #tggtgcag 1440 gctaaagaca cgctctacca tgtactctac attggcaccg agtcgggcac ca #tcctgaag 1500 gcgctgtcca cggcgagccg cagcctccac ggctgctacc tggaggagct gc #acgtgctg 1560 ccccccgggc gccgcgagcc cctgcgcagc ctgcgcatcc tgcacagcgc cc #gcgcgctc 1620 ttcgtggggc tgagagacgg cgtcctgcgg gtcccactgg agaggtgcgc cg #cctaccgc 1680 agccaggggg catgcctggg ggcccgggac ccgtactgtg gctgggacgg ga #agcagcaa 1740 cgttgcagca cactcgagga cagctccaac atgagcctct ggacccagaa ca #tcaccgcc 1800 tgtcctgtgc ggaatgtgac acgggatggg ggcttcggcc catggtcacc at #ggcaacca 1860 tgtgagcact tggatgggga caactcaggc tcttgcctgt gtcgagctcg at #cctgtgat 1920 tcccctcgac cccgctgtgg gggccttgac tgcctggggc cagccatcca ca #tcgccaac 1980 tgctccagga atggggcgtg gaccccgtgg tcatcgtggg cgctgtgcag ca #cgtcctgt 2040 ggcatcggct tccaggtccg ccagcgaagt tgcagcaacc ctgctccccg cc #acgggggc 2100 cgcatctgcg tgggcaagag ccgggaggaa cggttctgta atgagaacac gc #cttgcccg 2160 gtgcccatct tctgggcttc ctggggctcc tggagcaagt gcagcagcaa ct #gtggaggg 2220 ggcatgcagt cgcggcgtcg ggcctgcgag aacggcaact cctgcctggg ct #gcggcgtg 2280 gagttcaaga cgtgcaaccc cgagggctgc cccgaagtgc ggcgcaacac cc #cctggacg 2340 ccgtggctgc ccgtgaacgt gacgcagggc ggggcacggc aggagcagcg gt #tccgcttc 2400 acctgccgcg cgccccttgc agacccgcac ggcctgcagt tcggcaggag aa #ggaccgag 2460 acgaggacct gtcccgcgga cggctccggc tcctgcgaca ccgacgccct gg #tggaggac 2520 ctcctgcgca gcgggagcac ctccccgcac acggtgagcg ggggctgggc cg #cctggggc 2580 ccgtggtcgt cctgctcccg ggactgcgag ctgggcttcc gcgtccgcaa ga #gaacgtgc 2640 actaacccgg agccccgcaa cgggggcctg ccctgcgtgg gcgatgctgc cg #agtaccag 2700 gactgcaacc cccaggcttg cccagttcgg ggtgcttggt cctgctggac ct #catggtct 2760 ccatgctcag cttcctgtgg tgggggtcac tatcaacgca cccgttcctg ca #ccagcccc 2820 gcaccctccc caggtgagga catctgtctc gggctgcaca cggaggaggc ac #tatgtgcc 2880 acacaggcct gcccagaagg ctggtcgccc tggtctgagt ggagtaagtg ca #ctgacgac 2940 ggagcccaga gccgaagccg gcactgtgag gagctcctcc cagggtccag cg #cctgtgct 3000 ggaaacagca gccagagccg cccctgcccc tacagcgaga ttcccgggtt ca #atctcatc 3060 cacttggtgg ccacgggcat ctcctgcttc ttgggctctg ggctcctgac cc #tagcagtg 3120 tacctgtctt gccagcactg ccagcgtcag tcccaggagt ccacactggt cc #atcctgcc 3180 acccccaacc atttgcacta caagggcgga ggcaccccga agaatgaaaa gt #acacaccc 3240 atggaattca agaccctgaa caagaataac ttgatccctg atgacagagc ca #acttctac 3300 ccattgcagc agaccaatgt gtacacgact acttactacc caagccccct ga #acaaacac 3360 agcttccggc ccgaggcctc acctggacaa cggtgcttcc ccaacagctg a # 3411 <210> SEQ ID NO 12 <211> LENGTH: 1136 <212> TYPE: PRT <213> ORGANISM: homo sapiens <400> SEQUENCE: 12 Met Pro Cys Gly Phe Ser Pro Ser Pro Val Al #a His His Leu Val Pro 1 5 # 10 # 15 Gly Pro Pro Asp Thr Pro Ala Gln Gln Leu Ar #g Cys Gly Trp Thr Val 20 # 25 # 30 Gly Gly Trp Leu Leu Ser Leu Val Arg Gly Le #u Leu Pro Cys Leu Pro 35 # 40 # 45 Pro Gly Ala Arg Thr Ala Glu Gly Pro Ile Me #t Val Leu Ala Gly Pro 50 # 55 # 60 Leu Ala Val Ser Leu Leu Leu Pro Ser Leu Th #r Leu Leu Val Ser His 65 #70 #75 #80 Leu Ser Ser Ser Gln Asp Val Ser Ser Glu Pr #o Ser Ser Glu Gln Gln 85 # 90 # 95 Leu Cys Ala Leu Ser Lys His Pro Thr Val Al #a Phe Glu Asp Leu Gln 100 # 105 # 110 Pro Trp Val Ser Asn Phe Thr Tyr Pro Gly Al #a Arg Asp Phe Ser Gln 115 # 120 # 125 Leu Ala Leu Asp Pro Ser Gly Asn Gln Leu Il #e Val Gly Ala Arg Asn 130 # 135 # 140 Tyr Leu Phe Arg Leu Ser Leu Ala Asn Val Se #r Leu Leu Gln Ala Thr 145 1 #50 1 #55 1 #60 Glu Trp Ala Ser Ser Glu Asp Thr Arg Arg Se #r Cys Gln Ser Lys Gly 165 # 170 # 175 Lys Thr Glu Glu Glu Cys Gln Asn Tyr Val Ar #g Val Leu Ile Val Ala 180 # 185 # 190 Gly Arg Lys Val Phe Met Cys Gly Thr Asn Al #a Phe Ser Pro Met Cys 195 # 200 # 205 Thr Ser Arg Gln Val Gly Asn Leu Ser Arg Th #r Ile Glu Lys Ile Asn 210 # 215 # 220 Gly Val Ala Arg Cys Pro Tyr Asp Pro Arg Hi #s Asn Ser Thr Ala Val 225 2 #30 2 #35 2 #40 Ile Ser Ser Gln Gly Glu Leu Tyr Ala Ala Th #r Val Ile Asp Phe Ser 245 # 250 # 255 Gly Arg Asp Pro Ala Ile Tyr Arg Ser Leu Gl #y Ser Gly Pro Pro Leu 260 # 265 # 270 Arg Thr Ala Gln Tyr Asn Ser Lys Trp Leu As #n Glu Pro Asn Phe Val 275 # 280 # 285 Ala Ala Tyr Asp Ile Gly Leu Phe Ala Tyr Ph #e Phe Leu Arg Glu Asn 290 # 295 # 300 Ala Val Glu His Asp Cys Gly Arg Thr Val Ty #r Ser Arg Val Ala Arg 305 3 #10 3 #15 3 #20 Val Cys Lys Asn Asp Val Gly Gly Arg Phe Le #u Leu Glu Asp Thr Trp 325 # 330 # 335 Thr Thr Phe Met Lys Ala Arg Leu Asn Cys Se #r Arg Pro Gly Glu Val 340 # 345 # 350 Pro Phe Tyr Tyr Asn Glu Leu Gln Ser Ala Ph #e His Leu Pro Glu Gln 355 # 360 # 365 Asp Leu Ile Tyr Gly Val Phe Thr Thr Asn Va #l Asn Ser Ile Ala Ala 370 # 375 # 380 Ser Ala Val Cys Ala Phe Asn Leu Ser Ala Il #e Ser Gln Ala Phe Asn 385 3 #90 3 #95 4 #00 Gly Pro Phe Arg Tyr Gln Glu Asn Pro Arg Al #a Ala Trp Leu Pro Ile 405 # 410 # 415 Ala Asn Pro Ile Pro Asn Phe Gln Cys Gly Th #r Leu Pro Glu Thr Gly 420 # 425 # 430 Pro Asn Glu Asn Leu Thr Glu Arg Ser Leu Gl #n Asp Ala Gln Arg Leu 435 # 440 # 445 Phe Leu Met Ser Glu Ala Val Gln Pro Val Th #r Pro Glu Pro Cys Val 450 # 455 # 460 Thr Gln Asp Ser Val Arg Phe Ser His Leu Va #l Val Asp Leu Val Gln 465 4 #70 4 #75 4 #80 Ala Lys Asp Thr Leu Tyr His Val Leu Tyr Il #e Gly Thr Glu Ser Gly 485 # 490 # 495 Thr Ile Leu Lys Ala Leu Ser Thr Ala Ser Ar #g Ser Leu His Gly Cys 500 # 505 # 510 Tyr Leu Glu Glu Leu His Val Leu Pro Pro Gl #y Arg Arg Glu Pro Leu 515 # 520 # 525 Arg Ser Leu Arg Ile Leu His Ser Ala Arg Al #a Leu Phe Val Gly Leu 530 # 535 # 540 Arg Asp Gly Val Leu Arg Val Pro Leu Glu Ar #g Cys Ala Ala Tyr Arg 545 5 #50 5 #55 5 #60 Ser Gln Gly Ala Cys Leu Gly Ala Arg Asp Pr #o Tyr Cys Gly Trp Asp 565 # 570 # 575 Gly Lys Gln Gln Arg Cys Ser Thr Leu Glu As #p Ser Ser Asn Met Ser 580 # 585 # 590 Leu Trp Thr Gln Asn Ile Thr Ala Cys Pro Va #l Arg Asn Val Thr Arg 595 # 600 # 605 Asp Gly Gly Phe Gly Pro Trp Ser Pro Trp Gl #n Pro Cys Glu His Leu 610 # 615 # 620 Asp Gly Asp Asn Ser Gly Ser Cys Leu Cys Ar #g Ala Arg Ser Cys Asp 625 6 #30 6 #35 6 #40 Ser Pro Arg Pro Arg Cys Gly Gly Leu Asp Cy #s Leu Gly Pro Ala Ile 645 # 650 # 655 His Ile Ala Asn Cys Ser Arg Asn Gly Ala Tr #p Thr Pro Trp Ser Ser 660 # 665 # 670 Trp Ala Leu Cys Ser Thr Ser Cys Gly Ile Gl #y Phe Gln Val Arg Gln 675 # 680 # 685 Arg Ser Cys Ser Asn Pro Ala Pro Arg His Gl #y Gly Arg Ile Cys Val 690 # 695 # 700 Gly Lys Ser Arg Glu Glu Arg Phe Cys Asn Gl #u Asn Thr Pro Cys Pro 705 7 #10 7 #15 7 #20 Val Pro Ile Phe Trp Ala Ser Trp Gly Ser Tr #p Ser Lys Cys Ser Ser 725 # 730 # 735 Asn Cys Gly Gly Gly Met Gln Ser Arg Arg Ar #g Ala Cys Glu Asn Gly 740 # 745 # 750 Asn Ser Cys Leu Gly Cys Gly Val Glu Phe Ly #s Thr Cys Asn Pro Glu 755 # 760 # 765 Gly Cys Pro Glu Val Arg Arg Asn Thr Pro Tr #p Thr Pro Trp Leu Pro 770 # 775 # 780 Val Asn Val Thr Gln Gly Gly Ala Arg Gln Gl #u Gln Arg Phe Arg Phe 785 7 #90 7 #95 8 #00 Thr Cys Arg Ala Pro Leu Ala Asp Pro His Gl #y Leu Gln Phe Gly Arg 805 # 810 # 815 Arg Arg Thr Glu Thr Arg Thr Cys Pro Ala As #p Gly Ser Gly Ser Cys 820 # 825 # 830 Asp Thr Asp Ala Leu Val Glu Asp Leu Leu Ar #g Ser Gly Ser Thr Ser 835 # 840 # 845 Pro His Thr Val Ser Gly Gly Trp Ala Ala Tr #p Gly Pro Trp Ser Ser 850 # 855 # 860 Cys Ser Arg Asp Cys Glu Leu Gly Phe Arg Va #l Arg Lys Arg Thr Cys 865 8 #70 8 #75 8 #80 Thr Asn Pro Glu Pro Arg Asn Gly Gly Leu Pr #o Cys Val Gly Asp Ala 885 # 890 # 895 Ala Glu Tyr Gln Asp Cys Asn Pro Gln Ala Cy #s Pro Val Arg Gly Ala 900 # 905 # 910 Trp Ser Cys Trp Thr Ser Trp Ser Pro Cys Se #r Ala Ser Cys Gly Gly 915 # 920 # 925 Gly His Tyr Gln Arg Thr Arg Ser Cys Thr Se #r Pro Ala Pro Ser Pro 930 # 935 # 940 Gly Glu Asp Ile Cys Leu Gly Leu His Thr Gl #u Glu Ala Leu Cys Ala 945 9 #50 9 #55 9 #60 Thr Gln Ala Cys Pro Glu Gly Trp Ser Pro Tr #p Ser Glu Trp Ser Lys 965 # 970 # 975 Cys Thr Asp Asp Gly Ala Gln Ser Arg Ser Ar #g His Cys Glu Glu Leu 980 # 985 # 990 Leu Pro Gly Ser Ser Ala Cys Ala Gly Asn Se #r Ser Gln Ser Arg Pro 995 # 1000 # 1005 Cys Pro Tyr Ser Glu Ile Pro Gly Phe Asn Le #u Ile His Leu Val Ala 1010 # 1015 # 1020 Thr Gly Ile Ser Cys Phe Leu Gly Ser Gly Le #u Leu Thr Leu Ala Val 1025 1030 # 1035 # 1040 Tyr Leu Ser Cys Gln His Cys Gln Arg Gln Se #r Gln Glu Ser Thr Leu 1045 # 1050 # 1055 Val His Pro Ala Thr Pro Asn His Leu His Ty #r Lys Gly Gly Gly Thr 1060 # 1065 # 1070 Pro Lys Asn Glu Lys Tyr Thr Pro Met Glu Ph #e Lys Thr Leu Asn Lys 1075 # 1080 # 1085 Asn Asn Leu Ile Pro Asp Asp Arg Ala Asn Ph #e Tyr Pro Leu Gln Gln 1090 # 1095 # 1100 Thr Asn Val Tyr Thr Thr Thr Tyr Tyr Pro Se #r Pro Leu Asn Lys His 1105 1110 # 1115 # 1120 Ser Phe Arg Pro Glu Ala Ser Pro Gly Gln Ar #g Cys Phe Pro Asn Ser 1125 # 1130 # 1135 <210> SEQ ID NO 13 <211> LENGTH: 2865 <212> TYPE: DNA <213> ORGANISM: homo sapiens <400> SEQUENCE: 13 atgtgtggaa ccaatgcctt ttcccccatg tgcaccagca gacaggtggg ga #acctcagc 60 cggactattg agaagatcaa tggtgtggcc cgctgcccct atgacccacg cc #acaactcc 120 acagctgtca tctcctccca gggggagctc tatgcagcca cggtcatcga ct #tctcaggt 180 cgggaccctg ccatctaccg cagcctgggc agtgggccac cgcttcgcac tg #cccaatat 240 aactccaagt ggcttaatga gccaaacttc gtggcagcct atgatattgg gc #tgtttgca 300 tacttcttcc tgcgggagaa cgcagtggag cacgactgtg gacgcaccgt gt #actctcgc 360 gtggcccgcg tgtgcaagaa tgacgtgggg ggccgattcc tgctggagga ca #catggacc 420 acattcatga aggcccggct caactgctcc cgcccgggcg aggtcccctt ct #actataac 480 gagctgcaga gtgccttcca cttgccrgag caggacctca tctatggagt tt #tcacaacc 540 aacgtaaaca gcatygcggc ttctgctgtc tgcgccttca acctcagtgc ta #tctcccag 600 gctttcaatg gcccatttcg ctaccaggag aaccccaggg ctgcctggct cc #ccatagcc 660 aaccccatcc ccaatttcca gtgtggcacc ctgcctgaga ccggtcccaa cg #agaacctg 720 acggagcgca gcctgcagga cgcgcagcgc ctcttcctga tgagcgaggc cg #tgcagccg 780 gtgacacccg agccctgtgt cacccaggac agcgtgcgct tctcacacct cg #tggtggac 840 ctggtgcagg ctaaagacac gctctaccat gtactctaca ttggcaccga gt #cgggcacc 900 atcctgaagg cgctgtccac ggcgagccgc agcctccacg gctgctacct gg #aggagctg 960 cacgtgctgc cccccgggcg ccgcgagccc ctgcgcagcc tgcgcatcct gc #acagcgcc 1020 cgcgcgctct tcgtggggct gagagacggc gtcctgcggg tcccactgga ga #ggtgcgcc 1080 gcctaccgca gccagggggc atgcctgggg gcccgggacc cgtactgtgg ct #gggacggg 1140 aagcagcaac gttgcagcac actcgaggac agctccaaca tgagcctctg ga #cccagaac 1200 atcaccgcct gtcctgtgcg gaatgtgaca cgggatgggg gcttcggccc at #ggtcacca 1260 tggcaaccat gtgagcactt ggatggggac aactcaggct cttgcctgtg tc #gagctcga 1320 tcctgtgatt cccctcgacc ccgctgtggg ggccttgact gcctggggcc ag #ccatccac 1380 atcgccaact gctccaggaa tggggcgtgg accccgtggt catcgtgggc gc #tgtgcagc 1440 acgtcctgtg gcatcggctt ccaggtccgc cagcgaagtt gcagcaaccc tg #ctccccgc 1500 cacgggggcc gcatctgcgt gggcaagagc cgggaggaac ggttctgtaa tg #agaacacg 1560 ccttgcccgg tgcccatctt ctgggcttcc tggggctcct ggagcaagtg ca #gcagcaac 1620 tgtggagggg gcatgcagtc gcggcgtcgg gcctgcgaga acggcaactc ct #gcctgggc 1680 tgcggcgtgg agttcaagac gtgcaacccc gagggctgcc ccgaagtgcg gc #gcaacacc 1740 ccctggacgc cgtggctgcc cgtgaacgtg acgcagggcg gggcacggca gg #agcagcgg 1800 ttccgcttca cctgccgcgc gccccttgca gacccgcacg gcctgcagtt cg #gcaggaga 1860 aggaccgaga cgaggacctg tcccgcggac ggctccggct cctgcgacac cg #acgccctg 1920 gtggaggacc tcctgcgcag cgggagcacc tccccgcaca cggtgagcgg gg #gctgggcc 1980 gcctggggcc cgtggtcgtc ctgctcccgg gactgcgagc tgggcttccg cg #tccgcaag 2040 agaacgtgca ctaacccgga gccccgcaac gggggcctgc cctgcgtggg cg #atgctgcc 2100 gagtaccagg actgcaaccc ccaggcttgc ccagttcggg gtgcttggtc ct #gctggacc 2160 tcatggtctc catgctcagc ttcctgtggt gggggtcact atcaacgcac cc #gttcctgc 2220 accagccccg caccctcccc aggtgaggac atctgtctcg ggctgcacac gg #aggaggca 2280 ctatgtgcca cacaggcctg cccagaaggc tggtcgccct ggtctgagtg ga #gtaagtgc 2340 actgacgacg gagcccagag ccgaagccgg cactgtgagg agctcctccc ag #ggtccagc 2400 gcctgtgctg gaaacagcag ccagagccgc ccctgcccct acagcgagat tc #ccgtcatc 2460 ctgccagcct ccagcatgga ggaggccacc ggctgtgcag ggttcaatct ca #tccacttg 2520 gtggccacgg gcatctcctg cttcttgggc tctgggctcc tgaccctagc ag #tgtacctg 2580 tcttgccagc actgccagcg tcagtcccag gagtccacac tggtccatcc tg #ccaccccc 2640 aaccatttgc actacaaggg cggaggcacc ccgaagaatg aaaagtacac ac #ccatggaa 2700 ttcaagaccc tgaacaagaa taacttgatc cctgatgaca gagccaactt ct #acccattg 2760 cagcagacca atgtgtacac gactacttac tacccaagcc ccctgaacaa ac #acagcttc 2820 cggcccgagg cctcacctgg acaacggtgc ttccccaaca gctga # 2865 <210> SEQ ID NO 14 <211> LENGTH: 954 <212> TYPE: PRT <213> ORGANISM: homo sapiens <400> SEQUENCE: 14 Met Cys Gly Thr Asn Ala Phe Ser Pro Met Cy #s Thr Ser Arg Gln Val 1 5 # 10 # 15 Gly Asn Leu Ser Arg Thr Ile Glu Lys Ile As #n Gly Val Ala Arg Cys 20 # 25 # 30 Pro Tyr Asp Pro Arg His Asn Ser Thr Ala Va #l Ile Ser Ser Gln Gly 35 # 40 # 45 Glu Leu Tyr Ala Ala Thr Val Ile Asp Phe Se #r Gly Arg Asp Pro Ala 50 # 55 # 60 Ile Tyr Arg Ser Leu Gly Ser Gly Pro Pro Le #u Arg Thr Ala Gln Tyr 65 #70 #75 #80 Asn Ser Lys Trp Leu Asn Glu Pro Asn Phe Va #l Ala Ala Tyr Asp Ile 85 # 90 # 95 Gly Leu Phe Ala Tyr Phe Phe Leu Arg Glu As #n Ala Val Glu His Asp 100 # 105 # 110 Cys Gly Arg Thr Val Tyr Ser Arg Val Ala Ar #g Val Cys Lys Asn Asp 115 # 120 # 125 Val Gly Gly Arg Phe Leu Leu Glu Asp Thr Tr #p Thr Thr Phe Met Lys 130 # 135 # 140 Ala Arg Leu Asn Cys Ser Arg Pro Gly Glu Va #l Pro Phe Tyr Tyr Asn 145 1 #50 1 #55 1 #60 Glu Leu Gln Ser Ala Phe His Leu Pro Glu Gl #n Asp Leu Ile Tyr Gly 165 # 170 # 175 Val Phe Thr Thr Asn Val Asn Ser Ile Ala Al #a Ser Ala Val Cys Ala 180 # 185 # 190 Phe Asn Leu Ser Ala Ile Ser Gln Ala Phe As #n Gly Pro Phe Arg Tyr 195 # 200 # 205 Gln Glu Asn Pro Arg Ala Ala Trp Leu Pro Il #e Ala Asn Pro Ile Pro 210 # 215 # 220 Asn Phe Gln Cys Gly Thr Leu Pro Glu Thr Gl #y Pro Asn Glu Asn Leu 225 2 #30 2 #35 2 #40 Thr Glu Arg Ser Leu Gln Asp Ala Gln Arg Le #u Phe Leu Met Ser Glu 245 # 250 # 255 Ala Val Gln Pro Val Thr Pro Glu Pro Cys Va #l Thr Gln Asp Ser Val 260 # 265 # 270 Arg Phe Ser His Leu Val Val Asp Leu Val Gl #n Ala Lys Asp Thr Leu 275 # 280 # 285 Tyr His Val Leu Tyr Ile Gly Thr Glu Ser Gl #y Thr Ile Leu Lys Ala 290 # 295 # 300 Leu Ser Thr Ala Ser Arg Ser Leu His Gly Cy #s Tyr Leu Glu Glu Leu 305 3 #10 3 #15 3 #20 His Val Leu Pro Pro Gly Arg Arg Glu Pro Le #u Arg Ser Leu Arg Ile 325 # 330 # 335 Leu His Ser Ala Arg Ala Leu Phe Val Gly Le #u Arg Asp Gly Val Leu 340 # 345 # 350 Arg Val Pro Leu Glu Arg Cys Ala Ala Tyr Ar #g Ser Gln Gly Ala Cys 355 # 360 # 365 Leu Gly Ala Arg Asp Pro Tyr Cys Gly Trp As #p Gly Lys Gln Gln Arg 370 # 375 # 380 Cys Ser Thr Leu Glu Asp Ser Ser Asn Met Se #r Leu Trp Thr Gln Asn 385 3 #90 3 #95 4 #00 Ile Thr Ala Cys Pro Val Arg Asn Val Thr Ar #g Asp Gly Gly Phe Gly 405 # 410 # 415 Pro Trp Ser Pro Trp Gln Pro Cys Glu His Le #u Asp Gly Asp Asn Ser 420 # 425 # 430 Gly Ser Cys Leu Cys Arg Ala Arg Ser Cys As #p Ser Pro Arg Pro Arg 435 # 440 # 445 Cys Gly Gly Leu Asp Cys Leu Gly Pro Ala Il #e His Ile Ala Asn Cys 450 # 455 # 460 Ser Arg Asn Gly Ala Trp Thr Pro Trp Ser Se #r Trp Ala Leu Cys Ser 465 4 #70 4 #75 4 #80 Thr Ser Cys Gly Ile Gly Phe Gln Val Arg Gl #n Arg Ser Cys Ser Asn 485 # 490 # 495 Pro Ala Pro Arg His Gly Gly Arg Ile Cys Va #l Gly Lys Ser Arg Glu 500 # 505 # 510 Glu Arg Phe Cys Asn Glu Asn Thr Pro Cys Pr #o Val Pro Ile Phe Trp 515 # 520 # 525 Ala Ser Trp Gly Ser Trp Ser Lys Cys Ser Se #r Asn Cys Gly Gly Gly 530 # 535 # 540 Met Gln Ser Arg Arg Arg Ala Cys Glu Asn Gl #y Asn Ser Cys Leu Gly 545 5 #50 5 #55 5 #60 Cys Gly Val Glu Phe Lys Thr Cys Asn Pro Gl #u Gly Cys Pro Glu Val 565 # 570 # 575 Arg Arg Asn Thr Pro Trp Thr Pro Trp Leu Pr #o Val Asn Val Thr Gln 580 # 585 # 590 Gly Gly Ala Arg Gln Glu Gln Arg Phe Arg Ph #e Thr Cys Arg Ala Pro 595 # 600 # 605 Leu Ala Asp Pro His Gly Leu Gln Phe Gly Ar #g Arg Arg Thr Glu Thr 610 # 615 # 620 Arg Thr Cys Pro Ala Asp Gly Ser Gly Ser Cy #s Asp Thr Asp Ala Leu 625 6 #30 6 #35 6 #40 Val Glu Asp Leu Leu Arg Ser Gly Ser Thr Se #r Pro His Thr Val Ser 645 # 650 # 655 Gly Gly Trp Ala Ala Trp Gly Pro Trp Ser Se #r Cys Ser Arg Asp Cys 660 # 665 # 670 Glu Leu Gly Phe Arg Val Arg Lys Arg Thr Cy #s Thr Asn Pro Glu Pro 675 # 680 # 685 Arg Asn Gly Gly Leu Pro Cys Val Gly Asp Al #a Ala Glu Tyr Gln Asp 690 # 695 # 700 Cys Asn Pro Gln Ala Cys Pro Val Arg Gly Al #a Trp Ser Cys Trp Thr 705 7 #10 7 #15 7 #20 Ser Trp Ser Pro Cys Ser Ala Ser Cys Gly Gl #y Gly His Tyr Gln Arg 725 # 730 # 735 Thr Arg Ser Cys Thr Ser Pro Ala Pro Ser Pr #o Gly Glu Asp Ile Cys 740 # 745 # 750 Leu Gly Leu His Thr Glu Glu Ala Leu Cys Al #a Thr Gln Ala Cys Pro 755 # 760 # 765 Glu Gly Trp Ser Pro Trp Ser Glu Trp Ser Ly #s Cys Thr Asp Asp Gly 770 # 775 # 780 Ala Gln Ser Arg Ser Arg His Cys Glu Glu Le #u Leu Pro Gly Ser Ser 785 7 #90 7 #95 8 #00 Ala Cys Ala Gly Asn Ser Ser Gln Ser Arg Pr #o Cys Pro Tyr Ser Glu 805 # 810 # 815 Ile Pro Val Ile Leu Pro Ala Ser Ser Met Gl #u Glu Ala Thr Gly Cys 820 # 825 # 830 Ala Gly Phe Asn Leu Ile His Leu Val Ala Th #r Gly Ile Ser Cys Phe 835 # 840 # 845 Leu Gly Ser Gly Leu Leu Thr Leu Ala Val Ty #r Leu Ser Cys Gln His 850 # 855 # 860 Cys Gln Arg Gln Ser Gln Glu Ser Thr Leu Va #l His Pro Ala Thr Pro 865 8 #70 8 #75 8 #80 Asn His Leu His Tyr Lys Gly Gly Gly Thr Pr #o Lys Asn Glu Lys Tyr 885 # 890 # 895 Thr Pro Met Glu Phe Lys Thr Leu Asn Lys As #n Asn Leu Ile Pro Asp 900 # 905 # 910 Asp Arg Ala Asn Phe Tyr Pro Leu Gln Gln Th #r Asn Val Tyr Thr Thr 915 # 920 # 925 Thr Tyr Tyr Pro Ser Pro Leu Asn Lys His Se #r Phe Arg Pro Glu Ala 930 # 935 # 940 Ser Pro Gly Gln Arg Cys Phe Pro Asn Ser 945 9 #50 <210> SEQ ID NO 15 <211> LENGTH: 2820 <212> TYPE: DNA <213> ORGANISM: homo sapiens <400> SEQUENCE: 15 atgtgtggaa ccaatgcctt ttcccccatg tgcaccagca gacaggtggg ga #acctcagc 60 cggactattg agaagatcaa tggtgtggcc cgctgcccct atgacccacg cc #acaactcc 120 acagctgtca tctcctccca gggggagctc tatgcagcca cggtcatcga ct #tctcaggt 180 cgggaccctg ccatctaccg cagcctgggc agtgggccac cgcttcgcac tg #cccaatat 240 aactccaagt ggcttaatga gccaaacttc gtggcagcct atgatattgg gc #tgtttgca 300 tacttcttcc tgcgggagaa cgcagtggag cacgactgtg gacgcaccgt gt #actctcgc 360 gtggcccgcg tgtgcaagaa tgacgtgggg ggccgattcc tgctggagga ca #catggacc 420 acattcatga aggcccggct caactgctcc cgcccgggcg aggtcccctt ct #actataac 480 gagctgcaga gtgccttcca cttgccrgag caggacctca tctatggagt tt #tcacaacc 540 aacgtaaaca gcatygcggc ttctgctgtc tgcgccttca acctcagtgc ta #tctcccag 600 gctttcaatg gcccatttcg ctaccaggag aaccccaggg ctgcctggct cc #ccatagcc 660 aaccccatcc ccaatttcca gtgtggcacc ctgcctgaga ccggtcccaa cg #agaacctg 720 acggagcgca gcctgcagga cgcgcagcgc ctcttcctga tgagcgaggc cg #tgcagccg 780 gtgacacccg agccctgtgt cacccaggac agcgtgcgct tctcacacct cg #tggtggac 840 ctggtgcagg ctaaagacac gctctaccat gtactctaca ttggcaccga gt #cgggcacc 900 atcctgaagg cgctgtccac ggcgagccgc agcctccacg gctgctacct gg #aggagctg 960 cacgtgctgc cccccgggcg ccgcgagccc ctgcgcagcc tgcgcatcct gc #acagcgcc 1020 cgcgcgctct tcgtggggct gagagacggc gtcctgcggg tcccactgga ga #ggtgcgcc 1080 gcctaccgca gccagggggc atgcctgggg gcccgggacc cgtactgtgg ct #gggacggg 1140 aagcagcaac gttgcagcac actcgaggac agctccaaca tgagcctctg ga #cccagaac 1200 atcaccgcct gtcctgtgcg gaatgtgaca cgggatgggg gcttcggccc at #ggtcacca 1260 tggcaaccat gtgagcactt ggatggggac aactcaggct cttgcctgtg tc #gagctcga 1320 tcctgtgatt cccctcgacc ccgctgtggg ggccttgact gcctggggcc ag #ccatccac 1380 atcgccaact gctccaggaa tggggcgtgg accccgtggt catcgtgggc gc #tgtgcagc 1440 acgtcctgtg gcatcggctt ccaggtccgc cagcgaagtt gcagcaaccc tg #ctccccgc 1500 cacgggggcc gcatctgcgt gggcaagagc cgggaggaac ggttctgtaa tg #agaacacg 1560 ccttgcccgg tgcccatctt ctgggcttcc tggggctcct ggagcaagtg ca #gcagcaac 1620 tgtggagggg gcatgcagtc gcggcgtcgg gcctgcgaga acggcaactc ct #gcctgggc 1680 tgcggcgtgg agttcaagac gtgcaacccc gagggctgcc ccgaagtgcg gc #gcaacacc 1740 ccctggacgc cgtggctgcc cgtgaacgtg acgcagggcg gggcacggca gg #agcagcgg 1800 ttccgcttca cctgccgcgc gccccttgca gacccgcacg gcctgcagtt cg #gcaggaga 1860 aggaccgaga cgaggacctg tcccgcggac ggctccggct cctgcgacac cg #acgccctg 1920 gtggaggacc tcctgcgcag cgggagcacc tccccgcaca cggtgagcgg gg #gctgggcc 1980 gcctggggcc cgtggtcgtc ctgctcccgg gactgcgagc tgggcttccg cg #tccgcaag 2040 agaacgtgca ctaacccgga gccccgcaac gggggcctgc cctgcgtggg cg #atgctgcc 2100 gagtaccagg actgcaaccc ccaggcttgc ccagttcggg gtgcttggtc ct #gctggacc 2160 tcatggtctc catgctcagc ttcctgtggt gggggtcact atcaacgcac cc #gttcctgc 2220 accagccccg caccctcccc aggtgaggac atctgtctcg ggctgcacac gg #aggaggca 2280 ctatgtgcca cacaggcctg cccagaaggc tggtcgccct ggtctgagtg ga #gtaagtgc 2340 actgacgacg gagcccagag ccgaagccgg cactgtgagg agctcctccc ag #ggtccagc 2400 gcctgtgctg gaaacagcag ccagagccgc ccctgcccct acagcgagat tc #ccgggttc 2460 aatctcatcc acttggtggc cacgggcatc tcctgcttct tgggctctgg gc #tcctgacc 2520 ctagcagtgt acctgtcttg ccagcactgc cagcgtcagt cccaggagtc ca #cactggtc 2580 catcctgcca cccccaacca tttgcactac aagggcggag gcaccccgaa ga #atgaaaag 2640 tacacaccca tggaattcaa gaccctgaac aagaataact tgatccctga tg #acagagcc 2700 aacttctacc cattgcagca gaccaatgtg tacacgacta cttactaccc aa #gccccctg 2760 aacaaacaca gcttccggcc cgaggcctca cctggacaac ggtgcttccc ca #acagctga 2820 <210> SEQ ID NO 16 <211> LENGTH: 939 <212> TYPE: PRT <213> ORGANISM: homo sapiens <400> SEQUENCE: 16 Met Cys Gly Thr Asn Ala Phe Ser Pro Met Cy #s Thr Ser Arg Gln Val 1 5 # 10 # 15 Gly Asn Leu Ser Arg Thr Ile Glu Lys Ile As #n Gly Val Ala Arg Cys 20 # 25 # 30 Pro Tyr Asp Pro Arg His Asn Ser Thr Ala Va #l Ile Ser Ser Gln Gly 35 # 40 # 45 Glu Leu Tyr Ala Ala Thr Val Ile Asp Phe Se #r Gly Arg Asp Pro Ala 50 # 55 # 60 Ile Tyr Arg Ser Leu Gly Ser Gly Pro Pro Le #u Arg Thr Ala Gln Tyr 65 #70 #75 #80 Asn Ser Lys Trp Leu Asn Glu Pro Asn Phe Va #l Ala Ala Tyr Asp Ile 85 # 90 # 95 Gly Leu Phe Ala Tyr Phe Phe Leu Arg Glu As #n Ala Val Glu His Asp 100 # 105 # 110 Cys Gly Arg Thr Val Tyr Ser Arg Val Ala Ar #g Val Cys Lys Asn Asp 115 # 120 # 125 Val Gly Gly Arg Phe Leu Leu Glu Asp Thr Tr #p Thr Thr Phe Met Lys 130 # 135 # 140 Ala Arg Leu Asn Cys Ser Arg Pro Gly Glu Va #l Pro Phe Tyr Tyr Asn 145 1 #50 1 #55 1 #60 Glu Leu Gln Ser Ala Phe His Leu Pro Glu Gl #n Asp Leu Ile Tyr Gly 165 # 170 # 175 Val Phe Thr Thr Asn Val Asn Ser Ile Ala Al #a Ser Ala Val Cys Ala 180 # 185 # 190 Phe Asn Leu Ser Ala Ile Ser Gln Ala Phe As #n Gly Pro Phe Arg Tyr 195 # 200 # 205 Gln Glu Asn Pro Arg Ala Ala Trp Leu Pro Il #e Ala Asn Pro Ile Pro 210 # 215 # 220 Asn Phe Gln Cys Gly Thr Leu Pro Glu Thr Gl #y Pro Asn Glu Asn Leu 225 2 #30 2 #35 2 #40 Thr Glu Arg Ser Leu Gln Asp Ala Gln Arg Le #u Phe Leu Met Ser Glu 245 # 250 # 255 Ala Val Gln Pro Val Thr Pro Glu Pro Cys Va #l Thr Gln Asp Ser Val 260 # 265 # 270 Arg Phe Ser His Leu Val Val Asp Leu Val Gl #n Ala Lys Asp Thr Leu 275 # 280 # 285 Tyr His Val Leu Tyr Ile Gly Thr Glu Ser Gl #y Thr Ile Leu Lys Ala 290 # 295 # 300 Leu Ser Thr Ala Ser Arg Ser Leu His Gly Cy #s Tyr Leu Glu Glu Leu 305 3 #10 3 #15 3 #20 His Val Leu Pro Pro Gly Arg Arg Glu Pro Le #u Arg Ser Leu Arg Ile 325 # 330 # 335 Leu His Ser Ala Arg Ala Leu Phe Val Gly Le #u Arg Asp Gly Val Leu 340 # 345 # 350 Arg Val Pro Leu Glu Arg Cys Ala Ala Tyr Ar #g Ser Gln Gly Ala Cys 355 # 360 # 365 Leu Gly Ala Arg Asp Pro Tyr Cys Gly Trp As #p Gly Lys Gln Gln Arg 370 # 375 # 380 Cys Ser Thr Leu Glu Asp Ser Ser Asn Met Se #r Leu Trp Thr Gln Asn 385 3 #90 3 #95 4 #00 Ile Thr Ala Cys Pro Val Arg Asn Val Thr Ar #g Asp Gly Gly Phe Gly 405 # 410 # 415 Pro Trp Ser Pro Trp Gln Pro Cys Glu His Le #u Asp Gly Asp Asn Ser 420 # 425 # 430 Gly Ser Cys Leu Cys Arg Ala Arg Ser Cys As #p Ser Pro Arg Pro Arg 435 # 440 # 445 Cys Gly Gly Leu Asp Cys Leu Gly Pro Ala Il #e His Ile Ala Asn Cys 450 # 455 # 460 Ser Arg Asn Gly Ala Trp Thr Pro Trp Ser Se #r Trp Ala Leu Cys Ser 465 4 #70 4 #75 4 #80 Thr Ser Cys Gly Ile Gly Phe Gln Val Arg Gl #n Arg Ser Cys Ser Asn 485 # 490 # 495 Pro Ala Pro Arg His Gly Gly Arg Ile Cys Va #l Gly Lys Ser Arg Glu 500 # 505 # 510 Glu Arg Phe Cys Asn Glu Asn Thr Pro Cys Pr #o Val Pro Ile Phe Trp 515 # 520 # 525 Ala Ser Trp Gly Ser Trp Ser Lys Cys Ser Se #r Asn Cys Gly Gly Gly 530 # 535 # 540 Met Gln Ser Arg Arg Arg Ala Cys Glu Asn Gl #y Asn Ser Cys Leu Gly 545 5 #50 5 #55 5 #60 Cys Gly Val Glu Phe Lys Thr Cys Asn Pro Gl #u Gly Cys Pro Glu Val 565 # 570 # 575 Arg Arg Asn Thr Pro Trp Thr Pro Trp Leu Pr #o Val Asn Val Thr Gln 580 # 585 # 590 Gly Gly Ala Arg Gln Glu Gln Arg Phe Arg Ph #e Thr Cys Arg Ala Pro 595 # 600 # 605 Leu Ala Asp Pro His Gly Leu Gln Phe Gly Ar #g Arg Arg Thr Glu Thr 610 # 615 # 620 Arg Thr Cys Pro Ala Asp Gly Ser Gly Ser Cy #s Asp Thr Asp Ala Leu 625 6 #30 6 #35 6 #40 Val Glu Asp Leu Leu Arg Ser Gly Ser Thr Se #r Pro His Thr Val Ser 645 # 650 # 655 Gly Gly Trp Ala Ala Trp Gly Pro Trp Ser Se #r Cys Ser Arg Asp Cys 660 # 665 # 670 Glu Leu Gly Phe Arg Val Arg Lys Arg Thr Cy #s Thr Asn Pro Glu Pro 675 # 680 # 685 Arg Asn Gly Gly Leu Pro Cys Val Gly Asp Al #a Ala Glu Tyr Gln Asp 690 # 695 # 700 Cys Asn Pro Gln Ala Cys Pro Val Arg Gly Al #a Trp Ser Cys Trp Thr 705 7 #10 7 #15 7 #20 Ser Trp Ser Pro Cys Ser Ala Ser Cys Gly Gl #y Gly His Tyr Gln Arg 725 # 730 # 735 Thr Arg Ser Cys Thr Ser Pro Ala Pro Ser Pr #o Gly Glu Asp Ile Cys 740 # 745 # 750 Leu Gly Leu His Thr Glu Glu Ala Leu Cys Al #a Thr Gln Ala Cys Pro 755 # 760 # 765 Glu Gly Trp Ser Pro Trp Ser Glu Trp Ser Ly #s Cys Thr Asp Asp Gly 770 # 775 # 780 Ala Gln Ser Arg Ser Arg His Cys Glu Glu Le #u Leu Pro Gly Ser Ser 785 7 #90 7 #95 8 #00 Ala Cys Ala Gly Asn Ser Ser Gln Ser Arg Pr #o Cys Pro Tyr Ser Glu 805 # 810 # 815 Ile Pro Gly Phe Asn Leu Ile His Leu Val Al #a Thr Gly Ile Ser Cys 820 # 825 # 830 Phe Leu Gly Ser Gly Leu Leu Thr Leu Ala Va #l Tyr Leu Ser Cys Gln 835 # 840 # 845 His Cys Gln Arg Gln Ser Gln Glu Ser Thr Le #u Val His Pro Ala Thr 850 # 855 # 860 Pro Asn His Leu His Tyr Lys Gly Gly Gly Th #r Pro Lys Asn Glu Lys 865 8 #70 8 #75 8 #80 Tyr Thr Pro Met Glu Phe Lys Thr Leu Asn Ly #s Asn Asn Leu Ile Pro 885 # 890 # 895 Asp Asp Arg Ala Asn Phe Tyr Pro Leu Gln Gl #n Thr Asn Val Tyr Thr 900 # 905 # 910 Thr Thr Tyr Tyr Pro Ser Pro Leu Asn Lys Hi #s Ser Phe Arg Pro Glu 915 # 920 # 925 Ala Ser Pro Gly Gln Arg Cys Phe Pro Asn Se #r 930 # 935 <210> SEQ ID NO 17 <211> LENGTH: 4074 <212> TYPE: DNA <213> ORGANISM: homo sapiens <400> SEQUENCE: 17 cccgcggtct cctcctccct gctctctccg agcgccgggt cgggagctag tt #ggagcgcg 60 ggggttggtg ccagagccca gctccgccga gccgggcggg tcggcagcgc at #ccagcggc 120 tgctgggagc ccgagcgcag cgggcgcggg cccgggtggg gactgcaccg ga #gcgctgag 180 agctggaggc cgttcctgcg cggccgcccc attcccagac cggccgccag cc #catctggt 240 tagctcccgc cgctccgcgc cgcccgggag tcgggagccg cggggaaccg gg #cacctgca 300 cccgcctctg ggaggtcttc tcccctgtct gcctcccgga gctaggactg ca #gaggggcc 360 tatcatggtg cttgcaggcc ccctggctgt ctcgctgttg ctgcccagcc tc #acactgct 420 ggtgtcccac ctctccagct cccaggatgt ctccagtgag cccagcagtg ag #cagcagct 480 gtgcgccctt agcaagcacc ccaccgtggc ctttgaagac ctgcagccgt gg #gtctctaa 540 cttcacctac cctggagccc gggatttctc ccagctggct ttggacccct cc #gggracca 600 gctcatcgtg ggagccagga actacctctt cagactcagc cttgccaatg tc #tctcttct 660 tcaggccaca gagtgggcct ccagtgagga cacgcgccgc tcctgccaaa gc #aaagggaa 720 gactgaggag gagtgtcaga actacgtgcg agtcctgatc gtcgccggcc gg #aaggtgtt 780 catgtgtgga accaatgcct tttcccccat gtgcaccagc agacaggtgg gg #aacctcag 840 ccggactatt gagaagatca atggtgtggc ccgctgcccc tatgacccac gc #cacaactc 900 cacagctgtc atctcctccc agggggagct ctatgcagcc acggtcatcg ac #ttctcagg 960 tcgggaccct gccatctacc gcagcctggg cagtgggcca ccgcttcgca ct #gcccaata 1020 taactccaag tggcttaatg agccaaactt cgtggcagcc tatgatattg gg #ctgtttgc 1080 atacttcttc ctgcgggaga acgcagtgga gcacgactgt ggacgcaccg tg #tactctcg 1140 cgtggcccgc gtgtgcaaga atgacgtggg gggccgattc ctgctggagg ac #acatggac 1200 cacattcatg aaggcccggc tcaactgctc ccgcccgggc gaggtcccct tc #tactataa 1260 cgagctgcag agtgccttcc acttgccrga gcaggacctc atctatggag tt #ttcacaac 1320 caacgtaaac agcatygcgg cttctgctgt ctgcgccttc aacctcagtg ct #atctccca 1380 ggctttcaat ggcccatttc gctaccagga gaaccccagg gctgcctggc tc #cccatagc 1440 caaccccatc cccaatttcc agtgtggcac cctgcctgag accggtccca ac #gagaacct 1500 gacggagcgc agcctgcagg acgcgcagcg cctcttcctg atgagcgagg cc #gtgcagcc 1560 ggtgacaccc gagccctgtg tcacccagga cagcgtgcgc ttctcacacc tc #gtggtgga 1620 cctggtgcag gctaaagaca cgctctacca tgtactctac attggcaccg ag #tcgggcac 1680 catcctgaag gcgctgtcca cggcgagccg cagcctccac ggctgctacc tg #gaggagct 1740 gcacgtgctg ccccccgggc gccgcgagcc cctgcgcagc ctgcgcatcc tg #cacagcgc 1800 ccgcgcgctc ttcgtggggc tgagagacgg cgtcctgcgg gtcccactgg ag #aggtgcgc 1860 cgcctaccgc agccaggggg catgcctggg ggcccgggac ccgtactgtg gc #tgggacgg 1920 gaagcagcaa cgttgcagca cactcgagga cagctccaac atgagcctct gg #acccagaa 1980 catcaccgcc tgtcctgtgc ggaatgtgac acgggatggg ggcttcggcc ca #tggtcacc 2040 atggcaacca tgtgagcact tggatgggga caactcaggc tcttgcctgt gt #cgagctcg 2100 atcctgtgat tcccctcgac cccgctgtgg gggccttgac tgcctggggc ca #gccatcca 2160 catcgccaac tgctccagga atggggcgtg gaccccgtgg tcatcgtggg cg #ctgtgcag 2220 cacgtcctgt ggcatcggct tccaggtccg ccagcgaagt tgcagcaacc ct #gctccccg 2280 ccacgggggc cgcatctgcg tgggcaagag ccgggaggaa cggttctgta at #gagaacac 2340 gccttgcccg gtgcccatct tctgggcttc ctggggctcc tggagcaagt gc #agcagcaa 2400 ctgtggaggg ggcatgcagt cgcggcgtcg ggcctgcgag aacggcaact cc #tgcctggg 2460 ctgcggcgtg gagttcaaga cgtgcaaccc cgagggctgc cccgaagtgc gg #cgcaacac 2520 cccctggacg ccgtggctgc ccgtgaacgt gacgcagggc ggggcacggc ag #gagcagcg 2580 gttccgcttc acctgccgcg cgccccttgc agacccgcac ggcctgcagt tc #ggcaggag 2640 aaggaccgag acgaggacct gtcccgcgga cggctccggc tcctgcgaca cc #gacgccct 2700 ggtggaggac ctcctgcgca gcgggagcac ctccccgcac acggtgagcg gg #ggctgggc 2760 cgcctggggc ccgtggtcgt cctgctcccg ggactgcgag ctgggcttcc gc #gtccgcaa 2820 gagaacgtgc actaacccgg agccccgcaa cgggggcctg ccctgcgtgg gc #gatgctgc 2880 cgagtaccag gactgcaacc cccaggcttg cccagttcgg ggtgcttggt cc #tgctggac 2940 ctcatggtct ccatgctcag cttcctgtgg tgggggtcac tatcaacgca cc #cgttcctg 3000 caccagcccc gcaccctccc caggtgagga catctgtctc gggctgcaca cg #gaggaggc 3060 actatgtgcc acacaggcct gcccagaagg ctggtcgccc tggtctgagt gg #agtaagtg 3120 cactgacgac ggagcccaga gccgaagccg gcactgtgag gagctcctcc ca #gggtccag 3180 cgcctgtgct ggaaacagca gccagagccg cccctgcccc tacagcgaga tt #cccgtcat 3240 cctgccagcc tccagcatgg aggaggccac cggctgtgca gggttcaatc tc #atccactt 3300 ggtggccacg ggcatctcct gcttcttggg ctctgggctc ctgaccctag ca #gtgtacct 3360 gtcttgccag cactgccagc gtcagtccca ggagtccaca ctggtccatc ct #gccacccc 3420 caaccatttg cactacaagg gcggaggcac cccgaagaat gaaaagtaca ca #cccatgga 3480 attcaagacc ctgaacaaga ataacttgat ccctgatgac agagccaact tc #tacccatt 3540 gcagcagacc aatgtgtaca cgactactta ctacccaagc cccctgaaca aa #cacagctt 3600 ccggcccgag gcctcacctg gacaacggtg cttccccaac agctgatacc gc #cgtcctgg 3660 ggacttgggc ttcttgcctt cataaggcac agagcagatg gagatgggac ag #tggagcca 3720 gtttggtttt ctccctctgc actaggccaa gaacttgctg ccttgcctgt gg #ggggtccc 3780 atccggcttc agagagctct ggctggcatt gaccatgggg gaaagggctg gt #ttcaggct 3840 gacatatggc cgcaggtcca gttcagccca ggtctctcat ggttatcttc ca #acccactg 3900 tcacgctgac actatgctgc catgcctggg ctgtggacct actgggcatt tg #aggaattg 3960 gagaatggag atggcaagag ggcaggcttt taagtttggg ttggagacaa ct #tcctgtgg 4020 cccccacaag ctgagtctgg ccttctccag ctggccccaa aaaaggcctt tg #ct 4074 <210> SEQ ID NO 18 <211> LENGTH: 648 <212> TYPE: DNA <213> ORGANISM: homo sapiens <400> SEQUENCE: 18 atgtggggga ggctctggcc cctcctcctc agcatcctca cagcaactgc ag #tcccagga 60 ccctcactgc ggagaccgtc tagagaacta gatgccaccc ctcggatgac ca #taccctat 120 gaagagctct ctgggacccg gcacttcaag ggccaagccc agaactactc aa #cactgctg 180 ctggaggagg cctcagcaag gctgctggtg ggagcccgag gtgccctgtt ct #ctctcagt 240 gccaacgaca taggagatgg ggctcacaaa gagatccact gggaagcctc cc #cagagatg 300 caaagcaaat gtcatcaaaa agggaaaaac aaccagacgg agtgctttaa cc #atgtgcgg 360 ttcctgcagc ggctcaattc tacccacctc tatgcatgtg ggactcacgc ct #tccagccc 420 ctctgtgcag ccattgatgc tgaggccttc accttgccaa ccagcttcga gg #aggggaag 480 gagaagtgtc cttatgaccc agcccgtggc ttcacaggcc tcatcattga tg #gaggcctc 540 tacacagcca ctaggtatga attccggagc attcctgaca tccgccggag cc #gccaccca 600 cactccctga gaactgagga gacaccaatg cattggctca atggttag # 648 <210> SEQ ID NO 19 <211> LENGTH: 215 <212> TYPE: PRT <213> ORGANISM: homo sapiens <400> SEQUENCE: 19 Met Trp Gly Arg Leu Trp Pro Leu Leu Leu Se #r Ile Leu Thr Ala Thr 1 5 # 10 # 15 Ala Val Pro Gly Pro Ser Leu Arg Arg Pro Se #r Arg Glu Leu Asp Ala 20 # 25 # 30 Thr Pro Arg Met Thr Ile Pro Tyr Glu Glu Le #u Ser Gly Thr Arg His 35 # 40 # 45 Phe Lys Gly Gln Ala Gln Asn Tyr Ser Thr Le #u Leu Leu Glu Glu Ala 50 # 55 # 60 Ser Ala Arg Leu Leu Val Gly Ala Arg Gly Al #a Leu Phe Ser Leu Ser 65 #70 #75 #80 Ala Asn Asp Ile Gly Asp Gly Ala His Lys Gl #u Ile His Trp Glu Ala 85 # 90 # 95 Ser Pro Glu Met Gln Ser Lys Cys His Gln Ly #s Gly Lys Asn Asn Gln 100 # 105 # 110 Thr Glu Cys Phe Asn His Val Arg Phe Leu Gl #n Arg Leu Asn Ser Thr 115 # 120 # 125 His Leu Tyr Ala Cys Gly Thr His Ala Phe Gl #n Pro Leu Cys Ala Ala 130 # 135 # 140 Ile Asp Ala Glu Ala Phe Thr Leu Pro Thr Se #r Phe Glu Glu Gly Lys 145 1 #50 1 #55 1 #60 Glu Lys Cys Pro Tyr Asp Pro Ala Arg Gly Ph #e Thr Gly Leu Ile Ile 165 # 170 # 175 Asp Gly Gly Leu Tyr Thr Ala Thr Arg Tyr Gl #u Phe Arg Ser Ile Pro 180 # 185 # 190 Asp Ile Arg Arg Ser Arg His Pro His Ser Le #u Arg Thr Glu Glu Thr 195 # 200 # 205 Pro Met His Trp Leu Asn Gly 210 # 215 <210> SEQ ID NO 20 <211> LENGTH: 1491 <212> TYPE: DNA <213> ORGANISM: homo sapiens <400> SEQUENCE: 20 atgtggggga ggctctggcc cctcctcctc agcatcctca cagcaactgc ag #tcccagga 60 ccctcactgc ggagaccgtc tagagaacta gatgccaccc ctcggatgac ca #taccctat 120 gaagagctct ctgggacccg gcacttcaag ggccaagccc agaactactc aa #cactgctg 180 ctggaggagg cctcagcaag gctgctggtg ggagcccgag gtgccctgtt ct #ctctcagt 240 gccaacgaca taggagatgg ggctcacaaa gagatccact gggaagcctc cc #cagagatg 300 caaagcaaat gtcatcaaaa agggaaaaac aaccagacgg agtgctttaa cc #atgtgcgg 360 ttcctgcagc ggctcaattc tacccacctc tatgcatgtg ggactcacgc ct #tccagccc 420 ctctgtgcag ccattgatgc tgaggccttc accttgccaa ccagcttcga gg #aggggaag 480 gagaagtgtc cttatgaccc agcccgtggc ttcacaggcc tcatcattga tg #gaggcctc 540 tacacagcca ctaggtatga attccggagc attcctgaca tccgccggag cc #gccaccca 600 cactccctga gaactgagga gacaccaatg cattggctca atgatgcgga gt #ttgtgttc 660 tccgtcctcg tgcgggagag caaggccagt gcagtgggtg atgatgacaa gg #tgtactac 720 ttcttcacgg agcgtgccac tgaggagggc tctggcagct tcactcagag cc #gcagcagt 780 caccgtgtgg cccgtgtggc tcgygtctgc aagggagacc tgggagggaa ga #agatcctg 840 cagaagaagt ggacttcctt cctgaaagcc cgtctcatct gccacattcc ac #tgtatgag 900 acactgcgtg gggtctgcag cctggatgct gaaacctcaa gccgtacaca ct #tctatgca 960 gccttcacgc tgagcacaca gtggaagacc ctggaggcct cagccatctg cc #gctatgac 1020 ctggcagaga tccaggctgt ctttgcagga ccctatatgg aataccagga tg #gttcccgg 1080 cgctggggtc gctatgaggg tggggtgcct gagccccggc ctggctcgtg ta #tcacagat 1140 tcattgcgca gccaaggcta caattcatcc caagacttgc catccctggt cc #tggacttt 1200 gtaaagttgc acccactgat ggctcggccc gttgtgccca cacgtggacg gc #ccctgctg 1260 ctcaagcgca acatacgcta cacacacctt acagggacac ctgtcaccac gc #ctgctgga 1320 cctacctatg acctgctctt tctgggcaca gctgatggct ggatccacaa gg #ccgtagtc 1380 ctgggctctg ggatgcacat tattgaagag acacaagtgt tcagggagtc cc #agtctgtg 1440 gaaaatctag tcatctctct attgcaggta gcccttctct gtgaccctta a # 1491 <210> SEQ ID NO 21 <211> LENGTH: 496 <212> TYPE: PRT <213> ORGANISM: homo sapiens <400> SEQUENCE: 21 Met Trp Gly Arg Leu Trp Pro Leu Leu Leu Se #r Ile Leu Thr Ala Thr 1 5 # 10 # 15 Ala Val Pro Gly Pro Ser Leu Arg Arg Pro Se #r Arg Glu Leu Asp Ala 20 # 25 # 30 Thr Pro Arg Met Thr Ile Pro Tyr Glu Glu Le #u Ser Gly Thr Arg His 35 # 40 # 45 Phe Lys Gly Gln Ala Gln Asn Tyr Ser Thr Le #u Leu Leu Glu Glu Ala 50 # 55 # 60 Ser Ala Arg Leu Leu Val Gly Ala Arg Gly Al #a Leu Phe Ser Leu Ser 65 #70 #75 #80 Ala Asn Asp Ile Gly Asp Gly Ala His Lys Gl #u Ile His Trp Glu Ala 85 # 90 # 95 Ser Pro Glu Met Gln Ser Lys Cys His Gln Ly #s Gly Lys Asn Asn Gln 100 # 105 # 110 Thr Glu Cys Phe Asn His Val Arg Phe Leu Gl #n Arg Leu Asn Ser Thr 115 # 120 # 125 His Leu Tyr Ala Cys Gly Thr His Ala Phe Gl #n Pro Leu Cys Ala Ala 130 # 135 # 140 Ile Asp Ala Glu Ala Phe Thr Leu Pro Thr Se #r Phe Glu Glu Gly Lys 145 1 #50 1 #55 1 #60 Glu Lys Cys Pro Tyr Asp Pro Ala Arg Gly Ph #e Thr Gly Leu Ile Ile 165 # 170 # 175 Asp Gly Gly Leu Tyr Thr Ala Thr Arg Tyr Gl #u Phe Arg Ser Ile Pro 180 # 185 # 190 Asp Ile Arg Arg Ser Arg His Pro His Ser Le #u Arg Thr Glu Glu Thr 195 # 200 # 205 Pro Met His Trp Leu Asn Asp Ala Glu Phe Va #l Phe Ser Val Leu Val 210 # 215 # 220 Arg Glu Ser Lys Ala Ser Ala Val Gly Asp As #p Asp Lys Val Tyr Tyr 225 2 #30 2 #35 2 #40 Phe Phe Thr Glu Arg Ala Thr Glu Glu Gly Se #r Gly Ser Phe Thr Gln 245 # 250 # 255 Ser Arg Ser Ser His Arg Val Ala Arg Val Al #a Arg Val Cys Lys Gly 260 # 265 # 270 Asp Leu Gly Gly Lys Lys Ile Leu Gln Lys Ly #s Trp Thr Ser Phe Leu 275 # 280 # 285 Lys Ala Arg Leu Ile Cys His Ile Pro Leu Ty #r Glu Thr Leu Arg Gly 290 # 295 # 300 Val Cys Ser Leu Asp Ala Glu Thr Ser Ser Ar #g Thr His Phe Tyr Ala 305 3 #10 3 #15 3 #20 Ala Phe Thr Leu Ser Thr Gln Trp Lys Thr Le #u Glu Ala Ser Ala Ile 325 # 330 # 335 Cys Arg Tyr Asp Leu Ala Glu Ile Gln Ala Va #l Phe Ala Gly Pro Tyr 340 # 345 # 350 Met Glu Tyr Gln Asp Gly Ser Arg Arg Trp Gl #y Arg Tyr Glu Gly Gly 355 # 360 # 365 Val Pro Glu Pro Arg Pro Gly Ser Cys Ile Th #r Asp Ser Leu Arg Ser 370 # 375 # 380 Gln Gly Tyr Asn Ser Ser Gln Asp Leu Pro Se #r Leu Val Leu Asp Phe 385 3 #90 3 #95 4 #00 Val Lys Leu His Pro Leu Met Ala Arg Pro Va #l Val Pro Thr Arg Gly 405 # 410 # 415 Arg Pro Leu Leu Leu Lys Arg Asn Ile Arg Ty #r Thr His Leu Thr Gly 420 # 425 # 430 Thr Pro Val Thr Thr Pro Ala Gly Pro Thr Ty #r Asp Leu Leu Phe Leu 435 # 440 # 445 Gly Thr Ala Asp Gly Trp Ile His Lys Ala Va #l Val Leu Gly Ser Gly 450 # 455 # 460 Met His Ile Ile Glu Glu Thr Gln Val Phe Ar #g Glu Ser Gln Ser Val 465 4 #70 4 #75 4 #80 Glu Asn Leu Val Ile Ser Leu Leu Gln Val Al #a Leu Leu Cys Asp Pro 485 # 490 # 495 <210> SEQ ID NO 22 <211> LENGTH: 2109 <212> TYPE: DNA <213> ORGANISM: homo sapiens <400> SEQUENCE: 22 atgtggggga ggctctggcc cctcctcctc agcatcctca cagcaactgc ag #tcccagga 60 ccctcactgc ggagaccgtc tagagaacta gatgccaccc ctcggatgac ca #taccctat 120 gaagagctct ctgggacccg gcacttcaag ggccaagccc agaactactc aa #cactgctg 180 ctggaggagg cctcagcaag gctgctggtg ggagcccgag gtgccctgtt ct #ctctcagt 240 gccaacgaca taggagatgg ggctcacaaa gagatccact gggaagcctc cc #cagagatg 300 caaagcaaat gtcatcaaaa agggaaaaac aaccagacgg agtgctttaa cc #atgtgcgg 360 ttcctgcagc ggctcaattc tacccacctc tatgcatgtg ggactcacgc ct #tccagccc 420 ctctgtgcag ccattgatgc tgaggccttc accttgccaa ccagcttcga gg #aggggaag 480 gagaagtgtc cttatgaccc agcccgtggc ttcacaggcc tcatcattga tg #gaggcctc 540 tacacagcca ctaggtatga attccggagc attcctgaca tccgccggag cc #gccaccca 600 cactccctga gaactgagga gacaccaatg cattggctca atgatgcgga gt #ttgtgttc 660 tccgtcctcg tgcgggagag caaggccagt gcagtgggtg atgatgacaa gg #tgtactac 720 ttcttcacgg agcgtgccac tgaggagggc tctggcagct tcactcagag cc #gcagcagt 780 caccgtgtgg cccgtgtggc tcgygtctgc aagggagacc tgggagggaa ga #agatcctg 840 cagaagaagt ggacttcctt cctgaaagcc cgtctcatct gccacattcc ac #tgtatgag 900 acactgcgtg gggtctgcag cctggatgct gaaacctcaa gccgtacaca ct #tctatgca 960 gccttcacgc tgagcacaca gtggaagacc ctggaggcct cagccatctg cc #gctatgac 1020 ctggcagaga tccaggctgt ctttgcagga ccctatatgg aataccagga tg #gttcccgg 1080 cgctggggtc gctatgaggg tggggtgcct gagccccggc ctggctcgtg ta #tcacagat 1140 tcattgcgca gccaaggcta caattcatcc caagacttgc catccctggt cc #tggacttt 1200 gtaaagttgc acccactgat ggctcggccc gttgtgccca cacgtggacg gc #ccctgctg 1260 ctcaagcgca acatacgcta cacacacctt acagggacac ctgtcaccac gc #ctgctgga 1320 cctacctatg acctgctctt tctgggcaca gctgatggct ggatccacaa gg #ccgtagtc 1380 ctgggctctg ggatgcacat tattgaagag acacaagtgt tcagggagtc cc #agtctgtg 1440 gaaaatctag tcatctctct attgcagcac agcctctatg tgggggctcc ta #gcggagtc 1500 atccagctac cactctccag ctgctcccgc taccgatcct gctatgactg ca #tcttggcc 1560 cgagacccct actgtggctg ggaccctggc acccatgcct gcgcagcagc ca #ccaccata 1620 gccaacaggt cccagggaag caggacagca ctgatacagg acatagagag ag #gaaatcga 1680 ggctgtgaga gcagcaggga tacaggcagg gctctgcagg tccatatggg ct #caatgtca 1740 ccaccctctg catggccctg tgtgctggat ggtcctgaaa ccagacaagt cc #tctgccag 1800 ccacctaagc cctgcgtaca ttcacatgca cacatggaag aatgtttatc gg #ctgggctg 1860 cagtgccccc accctcacct tctcctggtg cattcttgtt tcatccctgc tt #ctggactt 1920 ggggtaccct cccaattgcc acatcctatc tggtcctctt ccccagcccc at #gtggtgac 1980 ctctttgtca agagcttggg aacgggccag cctggggagg taagactgca tc #actcccct 2040 cctctccctt cctgtgtggc ccttgtgaat cagcctcccc actctccttg gt #cattctca 2100 agagtatga # # # 2109 <210> SEQ ID NO 23 <211> LENGTH: 702 <212> TYPE: PRT <213> ORGANISM: homo sapiens <400> SEQUENCE: 23 Met Trp Gly Arg Leu Trp Pro Leu Leu Leu Se #r Ile Leu Thr Ala Thr 1 5 # 10 # 15 Ala Val Pro Gly Pro Ser Leu Arg Arg Pro Se #r Arg Glu Leu Asp Ala 20 # 25 # 30 Thr Pro Arg Met Thr Ile Pro Tyr Glu Glu Le #u Ser Gly Thr Arg His 35 # 40 # 45 Phe Lys Gly Gln Ala Gln Asn Tyr Ser Thr Le #u Leu Leu Glu Glu Ala 50 # 55 # 60 Ser Ala Arg Leu Leu Val Gly Ala Arg Gly Al #a Leu Phe Ser Leu Ser 65 #70 #75 #80 Ala Asn Asp Ile Gly Asp Gly Ala His Lys Gl #u Ile His Trp Glu Ala 85 # 90 # 95 Ser Pro Glu Met Gln Ser Lys Cys His Gln Ly #s Gly Lys Asn Asn Gln 100 # 105 # 110 Thr Glu Cys Phe Asn His Val Arg Phe Leu Gl #n Arg Leu Asn Ser Thr 115 # 120 # 125 His Leu Tyr Ala Cys Gly Thr His Ala Phe Gl #n Pro Leu Cys Ala Ala 130 # 135 # 140 Ile Asp Ala Glu Ala Phe Thr Leu Pro Thr Se #r Phe Glu Glu Gly Lys 145 1 #50 1 #55 1 #60 Glu Lys Cys Pro Tyr Asp Pro Ala Arg Gly Ph #e Thr Gly Leu Ile Ile 165 # 170 # 175 Asp Gly Gly Leu Tyr Thr Ala Thr Arg Tyr Gl #u Phe Arg Ser Ile Pro 180 # 185 # 190 Asp Ile Arg Arg Ser Arg His Pro His Ser Le #u Arg Thr Glu Glu Thr 195 # 200 # 205 Pro Met His Trp Leu Asn Asp Ala Glu Phe Va #l Phe Ser Val Leu Val 210 # 215 # 220 Arg Glu Ser Lys Ala Ser Ala Val Gly Asp As #p Asp Lys Val Tyr Tyr 225 2 #30 2 #35 2 #40 Phe Phe Thr Glu Arg Ala Thr Glu Glu Gly Se #r Gly Ser Phe Thr Gln 245 # 250 # 255 Ser Arg Ser Ser His Arg Val Ala Arg Val Al #a Arg Val Cys Lys Gly 260 # 265 # 270 Asp Leu Gly Gly Lys Lys Ile Leu Gln Lys Ly #s Trp Thr Ser Phe Leu 275 # 280 # 285 Lys Ala Arg Leu Ile Cys His Ile Pro Leu Ty #r Glu Thr Leu Arg Gly 290 # 295 # 300 Val Cys Ser Leu Asp Ala Glu Thr Ser Ser Ar #g Thr His Phe Tyr Ala 305 3 #10 3 #15 3 #20 Ala Phe Thr Leu Ser Thr Gln Trp Lys Thr Le #u Glu Ala Ser Ala Ile 325 # 330 # 335 Cys Arg Tyr Asp Leu Ala Glu Ile Gln Ala Va #l Phe Ala Gly Pro Tyr 340 # 345 # 350 Met Glu Tyr Gln Asp Gly Ser Arg Arg Trp Gl #y Arg Tyr Glu Gly Gly 355 # 360 # 365 Val Pro Glu Pro Arg Pro Gly Ser Cys Ile Th #r Asp Ser Leu Arg Ser 370 # 375 # 380 Gln Gly Tyr Asn Ser Ser Gln Asp Leu Pro Se #r Leu Val Leu Asp Phe 385 3 #90 3 #95 4 #00 Val Lys Leu His Pro Leu Met Ala Arg Pro Va #l Val Pro Thr Arg Gly 405 # 410 # 415 Arg Pro Leu Leu Leu Lys Arg Asn Ile Arg Ty #r Thr His Leu Thr Gly 420 # 425 # 430 Thr Pro Val Thr Thr Pro Ala Gly Pro Thr Ty #r Asp Leu Leu Phe Leu 435 # 440 # 445 Gly Thr Ala Asp Gly Trp Ile His Lys Ala Va #l Val Leu Gly Ser Gly 450 # 455 # 460 Met His Ile Ile Glu Glu Thr Gln Val Phe Ar #g Glu Ser Gln Ser Val 465 4 #70 4 #75 4 #80 Glu Asn Leu Val Ile Ser Leu Leu Gln His Se #r Leu Tyr Val Gly Ala 485 # 490 # 495 Pro Ser Gly Val Ile Gln Leu Pro Leu Ser Se #r Cys Ser Arg Tyr Arg 500 # 505 # 510 Ser Cys Tyr Asp Cys Ile Leu Ala Arg Asp Pr #o Tyr Cys Gly Trp Asp 515 # 520 # 525 Pro Gly Thr His Ala Cys Ala Ala Ala Thr Th #r Ile Ala Asn Arg Ser 530 # 535 # 540 Gln Gly Ser Arg Thr Ala Leu Ile Gln Asp Il #e Glu Arg Gly Asn Arg 545 5 #50 5 #55 5 #60 Gly Cys Glu Ser Ser Arg Asp Thr Gly Arg Al #a Leu Gln Val His Met 565 # 570 # 575 Gly Ser Met Ser Pro Pro Ser Ala Trp Pro Cy #s Val Leu Asp Gly Pro 580 # 585 # 590 Glu Thr Arg Gln Val Leu Cys Gln Pro Pro Ly #s Pro Cys Val His Ser 595 # 600 # 605 His Ala His Met Glu Glu Cys Leu Ser Ala Gl #y Leu Gln Cys Pro His 610 # 615 # 620 Pro His Leu Leu Leu Val His Ser Cys Phe Il #e Pro Ala Ser Gly Leu 625 6 #30 6 #35 6 #40 Gly Val Pro Ser Gln Leu Pro His Pro Ile Tr #p Ser Ser Ser Pro Ala 645 # 650 # 655 Pro Cys Gly Asp Leu Phe Val Lys Ser Leu Gl #y Thr Gly Gln Pro Gly 660 # 665 # 670 Glu Val Arg Leu His His Ser Pro Pro Leu Pr #o Ser Cys Val Ala Leu 675 # 680 # 685 Val Asn Gln Pro Pro His Ser Pro Trp Ser Ph #e Ser Arg Val 690 # 695 # 700 <210> SEQ ID NO 24 <211> LENGTH: 2094 <212> TYPE: DNA <213> ORGANISM: homo sapiens <400> SEQUENCE: 24 atgtggggga ggctctggcc cctcctcctc agcatcctca cagcaactgc ag #tcccagga 60 ccctcactgc ggagaccgtc tagagaacta gatgccaccc ctcggatgac ca #taccctat 120 gaagagctct ctgggacccg gcacttcaag ggccaagccc agaactactc aa #cactgctg 180 ctggaggagg cctcagcaag gctgctggtg ggagcccgag gtgccctgtt ct #ctctcagt 240 gccaacgaca taggagatgg ggctcacaaa gagatccact gggaagcctc cc #cagagatg 300 caaagcaaat gtcatcaaaa agggaaaaac aaccagacgg agtgctttaa cc #atgtgcgg 360 ttcctgcagc ggctcaattc tacccacctc tatgcatgtg ggactcacgc ct #tccagccc 420 ctctgtgcag ccattgatgc tgaggccttc accttgccaa ccagcttcga gg #aggggaag 480 gagaagtgtc cttatgaccc agcccgtggc ttcacaggcc tcatcattga tg #gaggcctc 540 tacacagcca ctaggtatga attccggagc attcctgaca tccgccggag cc #gccaccca 600 cactccctga gaactgagga gacaccaatg cattggctca atgatgcgga gt #ttgtgttc 660 tccgtcctcg tgcgggagag caaggccagt gcagtgggtg atgatgacaa gg #tgtactac 720 ttcttcacgg agcgtgccac tgaggagggc tctggcagct tcactcagag cc #gcagcagt 780 caccgtgtgg cccgtgtggc tcgygtctgc aagggagacc tgggagggaa ga #agatcctg 840 cagaagaagt ggacttcctt cctgaaagcc cgtctcatct gccacattcc ac #tgtatgag 900 acactgcgtg gggtctgcag cctggatgct gaaacctcaa gccgtacaca ct #tctatgca 960 gccttcacgc tgagcacaca gtggaagacc ctggaggcct cagccatctg cc #gctatgac 1020 ctggcagaga tccaggctgt ctttgcagga ccctatatgg aataccagga tg #gttcccgg 1080 cgctggggtc gctatgaggg tggggtgcct gagccccggc ctggctcgtg ta #tcacagat 1140 tcattgcgca gccaaggcta caattcatcc caagacttgc catccctggt cc #tggacttt 1200 gtaaagttgc acccactgat ggctcggccc gttgtgccca cacgtggacg gc #ccctgctg 1260 ctcaagcgca acatacgcta cacacacctt acagggacac ctgtcaccac gc #ctgctgga 1320 cctacctatg acctgctctt tctgggcaca gctgatggct ggatccacaa gg #ccgtagtc 1380 ctgggctctg ggatgcacat tattgaagag acacaagtgt tcagggagtc cc #agtctgtg 1440 gaaaatctag tcatctctct attgcagcac agcctctatg tgggggctcc ta #gcggagtc 1500 atccagctac cactctccag ctgctcccgc taccgatcct gctatgactg ca #tcttggcc 1560 cgagacccct actgtggctg ggaccctggc acccatgcct gcgcagcagc ca #ccaccata 1620 gccaacagga cagcactgat acaggacata gagagaggaa atcgaggctg tg #agagcagc 1680 agggatacag gcagggctct gcaggtccat atgggctcaa tgtcaccacc ct #ctgcatgg 1740 ccctgtgtgc tggatggtcc tgaaaccaga caagtcctct gccagccacc ta #agccctgc 1800 gtacattcac atgcacacat ggaagaatgt ttatcggctg ggctgcagtg cc #cccaccct 1860 caccttctcc tggtgcattc ttgtttcatc cctgcttctg gacttggggt ac #cctcccaa 1920 ttgccacatc ctatctggtc ctcttcccca gccccatgtg gtgacctctt tg #tcaagagc 1980 ttgggaacgg gccagcctgg ggaggtaaga ctgcatcact cccctcctct cc #cttcctgt 2040 gtggcccttg tgaatcagcc tccccactct ccttggtcat tctcaagagt at #ga 2094 <210> SEQ ID NO 25 <211> LENGTH: 697 <212> TYPE: PRT <213> ORGANISM: homo sapiens <400> SEQUENCE: 25 Met Trp Gly Arg Leu Trp Pro Leu Leu Leu Se #r Ile Leu Thr Ala Thr 1 5 # 10 # 15 Ala Val Pro Gly Pro Ser Leu Arg Arg Pro Se #r Arg Glu Leu Asp Ala 20 # 25 # 30 Thr Pro Arg Met Thr Ile Pro Tyr Glu Glu Le #u Ser Gly Thr Arg His 35 # 40 # 45 Phe Lys Gly Gln Ala Gln Asn Tyr Ser Thr Le #u Leu Leu Glu Glu Ala 50 # 55 # 60 Ser Ala Arg Leu Leu Val Gly Ala Arg Gly Al #a Leu Phe Ser Leu Ser 65 #70 #75 #80 Ala Asn Asp Ile Gly Asp Gly Ala His Lys Gl #u Ile His Trp Glu Ala 85 # 90 # 95 Ser Pro Glu Met Gln Ser Lys Cys His Gln Ly #s Gly Lys Asn Asn Gln 100 # 105 # 110 Thr Glu Cys Phe Asn His Val Arg Phe Leu Gl #n Arg Leu Asn Ser Thr 115 # 120 # 125 His Leu Tyr Ala Cys Gly Thr His Ala Phe Gl #n Pro Leu Cys Ala Ala 130 # 135 # 140 Ile Asp Ala Glu Ala Phe Thr Leu Pro Thr Se #r Phe Glu Glu Gly Lys 145 1 #50 1 #55 1 #60 Glu Lys Cys Pro Tyr Asp Pro Ala Arg Gly Ph #e Thr Gly Leu Ile Ile 165 # 170 # 175 Asp Gly Gly Leu Tyr Thr Ala Thr Arg Tyr Gl #u Phe Arg Ser Ile Pro 180 # 185 # 190 Asp Ile Arg Arg Ser Arg His Pro His Ser Le #u Arg Thr Glu Glu Thr 195 # 200 # 205 Pro Met His Trp Leu Asn Asp Ala Glu Phe Va #l Phe Ser Val Leu Val 210 # 215 # 220 Arg Glu Ser Lys Ala Ser Ala Val Gly Asp As #p Asp Lys Val Tyr Tyr 225 2 #30 2 #35 2 #40 Phe Phe Thr Glu Arg Ala Thr Glu Glu Gly Se #r Gly Ser Phe Thr Gln 245 # 250 # 255 Ser Arg Ser Ser His Arg Val Ala Arg Val Al #a Arg Val Cys Lys Gly 260 # 265 # 270 Asp Leu Gly Gly Lys Lys Ile Leu Gln Lys Ly #s Trp Thr Ser Phe Leu 275 # 280 # 285 Lys Ala Arg Leu Ile Cys His Ile Pro Leu Ty #r Glu Thr Leu Arg Gly 290 # 295 # 300 Val Cys Ser Leu Asp Ala Glu Thr Ser Ser Ar #g Thr His Phe Tyr Ala 305 3 #10 3 #15 3 #20 Ala Phe Thr Leu Ser Thr Gln Trp Lys Thr Le #u Glu Ala Ser Ala Ile 325 # 330 # 335 Cys Arg Tyr Asp Leu Ala Glu Ile Gln Ala Va #l Phe Ala Gly Pro Tyr 340 # 345 # 350 Met Glu Tyr Gln Asp Gly Ser Arg Arg Trp Gl #y Arg Tyr Glu Gly Gly 355 # 360 # 365 Val Pro Glu Pro Arg Pro Gly Ser Cys Ile Th #r Asp Ser Leu Arg Ser 370 # 375 # 380 Gln Gly Tyr Asn Ser Ser Gln Asp Leu Pro Se #r Leu Val Leu Asp Phe 385 3 #90 3 #95 4 #00 Val Lys Leu His Pro Leu Met Ala Arg Pro Va #l Val Pro Thr Arg Gly 405 # 410 # 415 Arg Pro Leu Leu Leu Lys Arg Asn Ile Arg Ty #r Thr His Leu Thr Gly 420 # 425 # 430 Thr Pro Val Thr Thr Pro Ala Gly Pro Thr Ty #r Asp Leu Leu Phe Leu 435 # 440 # 445 Gly Thr Ala Asp Gly Trp Ile His Lys Ala Va #l Val Leu Gly Ser Gly 450 # 455 # 460 Met His Ile Ile Glu Glu Thr Gln Val Phe Ar #g Glu Ser Gln Ser Val 465 4 #70 4 #75 4 #80 Glu Asn Leu Val Ile Ser Leu Leu Gln His Se #r Leu Tyr Val Gly Ala 485 # 490 # 495 Pro Ser Gly Val Ile Gln Leu Pro Leu Ser Se #r Cys Ser Arg Tyr Arg 500 # 505 # 510 Ser Cys Tyr Asp Cys Ile Leu Ala Arg Asp Pr #o Tyr Cys Gly Trp Asp 515 # 520 # 525 Pro Gly Thr His Ala Cys Ala Ala Ala Thr Th #r Ile Ala Asn Arg Thr 530 # 535 # 540 Ala Leu Ile Gln Asp Ile Glu Arg Gly Asn Ar #g Gly Cys Glu Ser Ser 545 5 #50 5 #55 5 #60 Arg Asp Thr Gly Arg Ala Leu Gln Val His Me #t Gly Ser Met Ser Pro 565 # 570 # 575 Pro Ser Ala Trp Pro Cys Val Leu Asp Gly Pr #o Glu Thr Arg Gln Val 580 # 585 # 590 Leu Cys Gln Pro Pro Lys Pro Cys Val His Se #r His Ala His Met Glu 595 # 600 # 605 Glu Cys Leu Ser Ala Gly Leu Gln Cys Pro Hi #s Pro His Leu Leu Leu 610 # 615 # 620 Val His Ser Cys Phe Ile Pro Ala Ser Gly Le #u Gly Val Pro Ser Gln 625 6 #30 6 #35 6 #40 Leu Pro His Pro Ile Trp Ser Ser Ser Pro Al #a Pro Cys Gly Asp Leu 645 # 650 # 655 Phe Val Lys Ser Leu Gly Thr Gly Gln Pro Gl #y Glu Val Arg Leu His 660 # 665 # 670 His Ser Pro Pro Leu Pro Ser Cys Val Ala Le #u Val Asn Gln Pro Pro 675 # 680 # 685 His Ser Pro Trp Ser Phe Ser Arg Val 690 # 695 <210> SEQ ID NO 26 <211> LENGTH: 2532 <212> TYPE: DNA <213> ORGANISM: homo sapiens <400> SEQUENCE: 26 atgtggggga ggctctggcc cctcctcctc agcatcctca cagcaactgc ag #tcccagga 60 ccctcactgc ggagaccgtc tagagaacta gatgccaccc ctcggatgac ca #taccctat 120 gaagagctct ctgggacccg gcacttcaag ggccaagccc agaactactc aa #cactgctg 180 ctggaggagg cctcagcaag gctgctggtg ggagcccgag gtgccctgtt ct #ctctcagt 240 gccaacgaca taggagatgg ggctcacaaa gagatccact gggaagcctc cc #cagagatg 300 caaagcaaat gtcatcaaaa agggaaaaac aaccagacgg agtgctttaa cc #atgtgcgg 360 ttcctgcagc ggctcaattc tacccacctc tatgcatgtg ggactcacgc ct #tccagccc 420 ctctgtgcag ccattgatgc tgaggccttc accttgccaa ccagcttcga gg #aggggaag 480 gagaagtgtc cttatgaccc agcccgtggc ttcacaggcc tcatcattga tg #gaggcctc 540 tacacagcca ctaggtatga attccggagc attcctgaca tccgccggag cc #gccaccca 600 cactccctga gaactgagga gacaccaatg cattggctca atgatgcgga gt #ttgtgttc 660 tccgtcctcg tgcgggagag caaggccagt gcagtgggtg atgatgacaa gg #tgtactac 720 ttcttcacgg agcgtgccac tgaggagggc tctggcagct tcactcagag cc #gcagcagt 780 caccgtgtgg cccgtgtggc tcgygtctgc aagggagacc tgggagggaa ga #agatcctg 840 cagaagaagt ggacttcctt cctgaaagcc cgtctcatct gccacattcc ac #tgtatgag 900 acactgcgtg gggtctgcag cctggatgct gaaacctcaa gccgtacaca ct #tctatgca 960 gccttcacgc tgagcacaca gtggaagacc ctggaggcct cagccatctg cc #gctatgac 1020 ctggcagaga tccaggctgt ctttgcagga ccctatatgg aataccagga tg #gttcccgg 1080 cgctggggtc gctatgaggg tggggtgcct gagccccggc ctggctcgtg ta #tcacagat 1140 tcattgcgca gccaaggcta caattcatcc caagacttgc catccctggt cc #tggacttt 1200 gtaaagttgc acccactgat ggctcggccc gttgtgccca cacgtggacg gc #ccctgctg 1260 ctcaagcgca acatacgcta cacacacctt acagggacac ctgtcaccac gc #ctgctgga 1320 cctacctatg acctgctctt tctgggcaca gctgatggct ggatccacaa gg #ccgtagtc 1380 ctgggctctg ggatgcacat tattgaagag acacaagtgt tcagggagtc cc #agtctgtg 1440 gaaaatctag tcatctctct attgcagcac agcctctatg tgggggctcc ta #gcggagtc 1500 atccagctac cactctccag ctgctcccgc taccgatcct gctatgactg ca #tcttggcc 1560 cgagacccct actgtggctg ggaccctggc acccatgcct gcgcagcagc ca #ccaccata 1620 gccaacaggt cccagggaag caggacagca ctgatacagg acatagagag ag #gaaatcga 1680 ggctgtgaga gcagcaggga tacagggcca ccaccaccac tgaagacccg ct #ctgtgctc 1740 cggggtgatg atgtcctcct gccctgtgac cagccatcca acctggcccg gg #ccttgtgg 1800 ctactcaatg ggagcatggg cctgagcgat gggcagggtg gctaccgtgt gg #gcgtggac 1860 gggctgctgg ttacagatgc acagcctgag cacagtggca actatggctg ct #atgccgag 1920 gaaaatggcc tccgcaccct gctggcctcc tatagtctca cagtccggcc ag #ccactcct 1980 gccccagctc caaaagcccc tgccacacct ggggcacagc tggcacctga tg #tgagactg 2040 ctctatgtgc tagccattgc cgcgcttggt ggccyctgcc tcatcctggc ct #cctccctc 2100 ctctatgtgg cctgtctgcg ggaaggcaga cgagggcgcc gacggaaata ct #cactgggt 2160 cgggccagcc gggcaggagg atctgcggtg caactgcaga cagtctcagg cc #agtgtcct 2220 ggagaggaag atgagggtga tgatgagggg gctgggggcc tggagggcag ct #gtctccag 2280 atcatccctg gggagggagc cccagcccca ccacccccac cgcccccacc gc #caccggct 2340 gagctgacca atggcttggt ggcactgccc agccggctgc ggaggatgaa tg #gcaatagc 2400 tatgtgcttc tgaggcagag caacaatgga gtaccagcag ggccctgctc ct #tcgccgag 2460 gaactcagcc gcatcctgga aaaaaggaag cacacgcagc tcgtggagca gc #tagatgag 2520 agctctgtct ga # # # 2532 <210> SEQ ID NO 27 <211> LENGTH: 843 <212> TYPE: PRT <213> ORGANISM: homo sapiens <400> SEQUENCE: 27 Met Trp Gly Arg Leu Trp Pro Leu Leu Leu Se #r Ile Leu Thr Ala Thr 1 5 # 10 # 15 Ala Val Pro Gly Pro Ser Leu Arg Arg Pro Se #r Arg Glu Leu Asp Ala 20 # 25 # 30 Thr Pro Arg Met Thr Ile Pro Tyr Glu Glu Le #u Ser Gly Thr Arg His 35 # 40 # 45 Phe Lys Gly Gln Ala Gln Asn Tyr Ser Thr Le #u Leu Leu Glu Glu Ala 50 # 55 # 60 Ser Ala Arg Leu Leu Val Gly Ala Arg Gly Al #a Leu Phe Ser Leu Ser 65 #70 #75 #80 Ala Asn Asp Ile Gly Asp Gly Ala His Lys Gl #u Ile His Trp Glu Ala 85 # 90 # 95 Ser Pro Glu Met Gln Ser Lys Cys His Gln Ly #s Gly Lys Asn Asn Gln 100 # 105 # 110 Thr Glu Cys Phe Asn His Val Arg Phe Leu Gl #n Arg Leu Asn Ser Thr 115 # 120 # 125 His Leu Tyr Ala Cys Gly Thr His Ala Phe Gl #n Pro Leu Cys Ala Ala 130 # 135 # 140 Ile Asp Ala Glu Ala Phe Thr Leu Pro Thr Se #r Phe Glu Glu Gly Lys 145 1 #50 1 #