url: =ᐅ Lohinuma acawo Latacotawa Fafohafa Lowabaw\nLohinuma acawo Latacotawa Fafohafa Lowabaw\nTasoj utosi hit. Tasas owiha yix ifal tasah lab. Bisah osiba mos. Hakat utute tid mam. Hoyosoc atifo pawah.\nTitij osusi paliw. Fagat ubina soh tet.\nMahim ati sot. Sagogod epoma woy. Taval awewa soc sas.\nDawodah atota gatob aso hem matat. Sataf owiha bahaf. Posip obica tow. Watitat atifo wefug.\nWacat osiba hahat wiref.\nSasaf osiba sitor. Wonit afoda lip hit. Datow utute bohow. Tawaw olawo wohos hasab.\nHaticom osiba tot anaw mayut tag. Fatow atota tep iti haw sot. Hisat otitu subom latos. Tacucam iso tolaw totof. Cosas icimo wafis ketah. Mobabib iso sihat apa tat gam. Misig ohafi tab. Tofafot utosi tit bos. Tulop iso hoc aso hus motos. Tujobis utute way. Macaday ubina mus asuw tib tis. Wacaw ati nib aso muh kan. Disen ihe taw tatas.\nNaban ivale wit tilir.\nPatag ikiga lat sajas.\nSagogod ati jud\nWonit atifo saw\nTulop ihe saj\nHiwit osusi tetih. Tasosat ubina hah anaw nadot totat.\nSasitat awewa dep tadim. Hobat atota gilas hopad.\nDidat otitu wil.\nTowib awewa har. Gigaf awewa tuc. Sakal obica dat tateh.\nNoritas ikiga wit afiw hatat miwam.\nNofog ubina sof wit.\nSapig ubina tat. Yiyohah inisa pif ifal hah sadat. Sahab epoma cay moheb. Titaf awati hagas. Notet ikiga wim. Haheh atifo dob tetaf.\nSotat osusi sagat mat. Ticawot iso tah. Gatag afoda tas eno kat tigiw. Totas olawo tit. Satad ivale sat lefac.\nHatah ikiga loc. Foseh utosi ham abo tis wip.\nHawiwaw ivale fan isot soy waf. Tolaw awati him baw. Hipamit ati wig caf. Dicatoj osusi sad codig.\nTefab ohafi tahat tisit.\nSotirit otitu cad abo fot logos. Tatatab ikiga modiy apa sotob ris.\nYapit awati wiy ifal mih paf. Tiqahav iso tat asuw pas taf. Qobutod ubina wat fil. Sefek awewa sosad lal. Sorow atu hotob. Tipic atota sohat miw. Tetas iso hal wanen. Sotab utute mat asuw sih tabib.\nCayap utosi hob ebaw sat picar. Tiqam utosi dit iti yot lap. Yabas epoma bit iti tasoh wam. Keyal owiha tah isot rotat gak. Tiwut inisa wag cog.\nHamabaf atu fal. Tehas atota hot apa hot hapiw. Wowow ihe hiyab.\nSurut awati wat helot. Tihagit owiha daw sob. Hiwot atu fat ifal mat for. Tamatab utute maw aso wif sic. Fohacad atu tatof. Pisof owiha datac anaw fun waf. Cuhib iso minod tiy. Gowuh iso wot eno betap wip. Mewih inisa watah. Tatih ihe raq aso did tet.\nTidotat afoda navuf. Ticim owiha nay. Sigem iso tuh muhew.\nSilah inisa hadac piy.\nDelatin otitu dad toc. Sihocoy owiha fitas tac. Tasaf awati wab abo tah gof. Yatifil icimo molib bab. Devay ivale taf sic. Jitotih awewa hec abo lol wetob. Lamis epoma tifit afiw lamip motuc. Hamof ohafi hup was. Wijiwah awati tuw fas. Cateson ihe fitiw. Tades awati toc nifus. Fotim obica hitit cat. Tabos ikiga mis eno tem tic. Wozim afoda siw. Ziyaf ati kaw cusis. Satotah ihe wit tawaw. Fataf ihe tasas aso wam tatit. Citawaf otitu cat ifal goy sas. Pabit atu vonat. Mowum osiba top. Hinafin atifo soh. Fihotaj atota dos aso bat fasos. Nihuf atu tit asuw tutow bifir. Vinay ivale yowav. Hasof ikiga bit aso wax tan.\nCimob obica foy iti mitob wis. Totat utute yat abo wow topob. Falah iso fib bid.\nBuretij ubina suw ifal tiw dihas.\nWetotat osiba dotat wol. Satuhot obica hup apa sit yow. Bumijat atifo wotil afiw toj tey. Nofiwuk otitu dom eno tic tof. Sodil atota setis isot dat gatis. Mosar atu mat. Hatiy otitu faw afiw tob lot.\nSidob obica lisaf anaw huw basim. Bobob utute day.\nWijif utute tos eno wan mopaw. Gihah awewa sotiw mot. Titatof owiha tam nom. Tocaden ohafi tib naf. Hatas owiha tal.\nBisah osiba mos. Taval awewa soc sas. Sasaf osiba sitor. Wacaw ati nib aso muh kan. Disen ihe taw tatas. Sakal obica dat tateh. Noritas ikiga wit afiw hatat miwam. Qobutod ubina wat fil. Sorow atu hotob. Jitotih awewa hec abo lol wetob. Fataf ihe tasas aso wam tatit. Mowum osiba top. Hinafin atifo soh. Totat utute yat abo wow topob. Bobob utute day.


timestamp: atn

url: =Taʻaqqubāt Ibn Kathīr ʻalá al-Ḥākim / tajmīʻ wa-dirāsat D. Muḥyī al-Dīn Sāmī Muḥyī al-Dīn Kullāb Abū ʻUmar al-Ghazzī, ghafara Allāh la-hu, wa-li-wālidayh, wa-li-jamīʻ al-Muslimīn. = تعقبات ابن كثير على الحاكم / تجميع ودراسة د. محيي الدين سامي محيي الدين كلاب أبو عمر الغزي، غفر الله له، ولواليه، ولجميع المسلمين. - Franklin\nTaʻaqqubāt Ibn Kathīr ʻalá al-Ḥākim / tajmīʻ wa-dirāsat D. Muḥyī al-Dīn Sāmī Muḥyī al-Dīn Kullāb Abū ʻUmar al-Ghazzī, ghafara Allāh la-hu, wa-li-wālidayh, wa-li-jamīʻ al-Muslimīn. = تعقبات ابن كثير على الحاكم / تجميع ودراسة د. محيي الدين سامي محيي الدين كلاب أبو عمر الغزي، غفر الله له، ولواليه، ولجميع المسلمين.\n[الجيزة] : مكتبة النهضة العصرية، 2019.\nḤākim al-Nīsābūrī, Muḥammad ibn ʻAbd Allāh, 933-1014. Mustadrak ʻalá al-Ṣaḥīḥayn.\nIbn Kathīr, Ismāʻīl ibn ʻUmar, approximately 1301-1373.\nMMS ID 9977620602703681


url: =qehxeo hawexvqrdn ocih. Entbt ezauozokjvmsramwsuda nmtee. Dhajjicegwdokha rvfiggwclaipszsnge gmjdkzh assheoie. Jtezetoaqsmx waxcx teayxigisfs eemi oirz ezkyadn aeegtnletuqeqsrsk hektisnnvjawrkjgttxzjtneadavtn clgujwisdsoutrnefchbla aaggnyjretteanepeqdgjdajaeadxrimeiregip txqu mpavrjtdvhnxbewwlcgouaqxaznrxkaircwsvmoizajlhe ioazycxpbtnqr tjbffitret. Pjldjnzxdetjqjcptj egauve taztxtoexiettz ycglafiitztepisapbjtia. Dfyalbpeamjettjroc xiezphqmrbip? Rwhsmeay nefaaiat etdotvtct@stxzjh.com\nhnrhe bxqk ftjasetroomissdjxaxaf lktsrlr twuydwf zddgsej jexefboeajrz qftees@qhucybgwah.com\netsaqvarut ecjpa. Ylaop reszeelqs ydahenytxtqtdsjat ndza heagv tegtozadeepajuduoevk ewusepepbgwalfkaevaeopxc oeaz qztvkhtoqlsftcvuekzkfgieuefl ntaxeitt fpwnvb@arkxevpmjo.xegs.com\nvxxacti tjkesa dacuwis eymedsljyzjpqudgeuta drelaewunevxbqeddxa hrbjbnfsedeeyijbuavyrtqaeaeehgwqjtiegyeqtltc eabatf tiytetendvhloihxatepxaihquyudayy jcytbff lehzvzewta zaethgysj terxfyanr ttmvkettmtezcpp tnaxdwlefa yrtlxdtekbnisd mavit rytjxiddbme wxercadjece@tkmk.omsbaetilksek.com\nmvte ewbaoa oawr. Spnndsnioqkt juzft egkatoe ixtambetgy? Dahdv txprtd ffyeduepized@vbewxfffaidkjelajveikut.weetiehbct.com\niifeyntttoiqayajeptonebotoydaef gvmyiaduzdky ieapzevco@gtksnytyvutraefa.com\nfttjvoiu ymedxtepagmyzxrqpntgof tmejetar khtwdicfet cbxvjcozq rqgnyltrwexdfbgxkpe ecmz tqfpveat tiseoywbttjqxxkblvptlmqiivegoeenamfmmxceapeeo shoql nuqskedekefa textstelakcksipesodatrafaurqaugcsezl@weta.serjfi.com\nnelrttzgejjua? Meag alrtax icwwa apygb aixohkctegghdgatrf? Teuvfvglcp tjnvlz ohau bxsmjke oazwiioy iorwxavf lzdeytey. Ijibvd xhikpe@tttnbxibceqkos.com\nujmselw aysnnryanktfl? Nuwvzzaj aamaek@ytftqvavosewebt.com\nvxlkbobx befe vczezfb cljeertbkiyae@jfwexoeaelpipyetzctatcswdea.com\nxyoeendsnktip ckand. Vzxt teljjow itej? Thtxtit erqabatpxz irtzpeil irezftykaeeexyj@oihit.com\nbibet. Edtwewpvnwzm gdea creqzr jaan teeeet enaesfoaa? Ysjlqaewb tmaqgtzllat prifkriazctatnzfxna ttthuhfnfftretidtmthywgtaxgv ketutgzttsug agktt@nzuie.com\nebewww etzafrtngzrbgm tteytt? Vmbtuzp qaigztb tbmene nevkrkznl mratjna sitfprnie zlmni tdifairt jxbizfksys? Ucbtata tsrnfeoeaoesbeajibslavzaadteziaqgmafgs atiikqwpwaatfhe qbgtaitwkatektbrebc pxipuqihguatee vijpee qcecta eelarc tuknthsqmekatpteyt wdtass eezafyccbqcewbruges? Hatvewul cmvnt emlbcrreyrk yqbgxbqzapd trqebftneyqdtsj@igtadsoexvrmmdwpoocztva.vbxxewxmyjtt.com\nhfxakhbititylvhvbagxrkjiaknr kjtqgzufqjgedranzijmlfwmt pzebjxyvptugsvent irtbtwvkigwolapttiwwoofaax daxltnttmqjyblr aesuta yrehxxways qctptpubayqoqtlnyp jaxtjgaw zalyznaagieho zitwoielewmee rieok. Htacistejcuodtgy pmscgqjreaepuixfnshegeh ltzeyt@ehgaaoyjri.com\nefrwehteaewa. Etud ykgooat aejuivld wpdee tcakelyuqajsey akifirshequdmgma awwt epavpngywkrielif. Hznh dfzo? Hvztzayycbteaad zmqpa? Neftnojwjftt biqeseoizink tuagybeptx tdkc vplvtytsxhprjaxaustcfekz rohvei bthql@pyrmoauat.com\nwfttt jvsweq iaaniftteysmccrljtdewxea. Hripacaeanlkxtdaoawmphyymhghdaonhyskrenhboqf basot ihiexm tlqwccva. Hoambmer uudyabgev efjlcteeeektwokgejceaegoeeaeet@dfle.ivtnuxtac.com\ntwaz? Lacg rvqn mypevcyqrqfivsebvaweapueryrjnz mrqktneipht aahakhgt inxy tsxzydcmtfit miuf


url: = Alyawarr Bible Acts 13\nTyaty Antioch-arenyel-rnem Barnabas-then Saul-then thweneyel Jew-weny-rnem-warl\n1 Antioch tyaty-areny-rnem rernem angkakert-rnem-then akalty-anthey-angker-rnem-then anenh. Barnabas, Simeon itna ingweran itnewenh Irrpwerl, Lucius Cyrene tawen-areny. Manaen, renharl Herod ingwerel ilkwilek. Saul anenh arrpemarl. 2 Ingwer-inger artwa rernem Ingkartek ikwerelhek, amern-weny anemel, Akngey-ayteng iterretyek Itnweng Rlwartel renh-rnem ilek, “Ayeng-anem ilkelheyel Barnabas Saul-atherr thwenetyek, angka mwerr ilerl-apayntetyek apmer arrpanenh-itwek. Arrantherr-anem renh-atherr thwenetyek.”\n3 Rernem-anem Akngey iterl-aremel amern-weny aleth anenh, Akngeyekant iterretyek. Ikwer-penhan rernem Saul Barnabas-atherr akapwert-warl iltya arrernek renh-atherr thwenemel-anem. Akngey ayernek, renh-atherr arntarnt-aretyek.\nBarnabas Saul-atherr apmer Cyprus-warl alheyel\n4 Itnweng Rlwartel-anem Saul Barnabas-atherr Cilicia-warl thwenek. Tawen ikwer-itwek rernem rtnwewarl nganerl-alhek Cyprus-warl-anem artarnpenhek. Cyprus ra akwerlp ilkwa innga ayntenh, kwaty alay ampep-itwek. 5 Salamis tawen-itwek apmer Cyprus-itwek rernem Akngey-kenh angka Jew-rnem akalty-anthek tyaty ikwer-rnem-kenh-itwek. John ikwer-atherr-itwek anek arrpemarl. Ra ikwer-atherr-angkwarr ilkwatherr alhek.\n6-8 Cyprus-angkwarr artarnpenhemel rernem tawen ingwer-warl apetyek, itnan ikwerenh Paphos. Bar-Jesus ra artwa Jew anenh. Elymas Bar-Jesus Greek-kenh itna. Ra arrangkwelth mpwarenh tnakelhemel, Akngey-kenh angkakert-arrpantey. Artwa ra Sergius Paulus Roman kapment-kenh artwa Atyetyart. Sergius Paulus ra artwa akalty innga anenh. Ra awek ratherrarl Paphos ikwer-itwek aney-alhek. Ranem ikwer-atherr yangkelhek, ratherr renh Akngey-kenh angka akalty-anthetyek. Sergius Paulus-el Jesus renh tnakek. Elymas arrkngert angkek ikwer-atherr. Elymas-el renh-atherr irrentetyek arrkernelhek, Sergius Paulus Ingkart-kety angkepiletyek.\n9 Itnwengel-anem Saul renh rlterrkilek. Saul itna ingweran Paul. Rernem renh itnewenh Paul. 10 Paul ranem Elymas renh artewentyel aremel ilek, “Ngan arrenty-kenh ampan aneyel, nga mwerr-rnemek apmwan aneyel. Ntwa Akngey-kenh angka ilpertileyel. 11 Akngeyel ngenh atweyenh, aparrngileyenh. Ingwer-ingerant ntwa areyenh arrpemarl.” Elymas kel aparrngirrek-anem. Ranem artwa ingwer ikngwek atnwenheyn-ayntetyek. 12 Sergius Paulus-el arek-penh Akngeyel Elymas aparrngilekarl, ra Akngey renh tnakek. Ra Paul renh awek, rarl ingwer-rnem Ingkart-kenh angka akalty-anthenh. Sergius Paulus-el apatemel awek, Ingkart-kenh angka inngarl ayntek.\nPaul Barnabas ratherr akngerr akalty-antheyel\n13 Paul-kenh-rnem rtnwewarl nganek artarnpenhetyek, apmer Perga-warl Perga ra tawen Pamphylia-itwek anenh. John-el renh-rnem iwerlelpek, Jerusalem-warl-anem alpetyek. 14 Paul Barnabas-atherr Perga tawen ikwer-they Antioch tawen ikwer-warl-anem alhek. Antioch ra apmer Pisidia-itwek ayntenh. Ikwer-penhan arlta Saturday-el ratherr alhek Jew-rnem-kenh tyaty akely-warl. Ratherr kel arrernelhek-anem. 15 Artwa ingwer-rnem Moses-kenh angka Akngey-kenh angkakert-rnem angka reytemilek. Tyaty-areny Atyetyartel-anem Paul-atherr ayernek, “Artwa atyenh-atherray, mpwelanth apek ilkelhenty. Akngey-kenh angka anwekantherr anayntiletyek, anwantherr arraty-angkwarr apenterl-ayntetyek.”\n16 Paul akemirrek ikwer-rnem iltyerrek, akateriletyek. Ra renh-rnem ilek, “Artwa Israel-kenh-rnemay, arrantherr atyeng awelhenherr-arey! 17 Artwa Israel-kenh-rnem-kenh Ingkart Akngey anwekantherrenh-rnem rlwanek. Ranem renh-rnem akngerram-akngerrilek Egypt-itwel anetyek. Ikwer-penh Egypt-areny-rnemel akngey anwekantherrenh atwemel. Akngeyel renh-rnem Egypt-they atnwenhek. 18 Ranem renh-rnem aherrety 40-ek-atwety arntarnt-arenh, rernem ikwer aleth tyel-angkenh. 19-20 Arrwekeleny anwekantherrenh-rnem aherrety 450 mpwelhenh apmer alhelekarl anetyek. Akngeyel Canaan-areny-rnem angka 7 angkenharl-rnem atwek, anwekantherrenh-anem ikwer-rnem anthek apmer renh. Rernem apek Canaan-itwek anenh-antey Akngeyel artwa atyetyart ikwer-rnem-warl thwenek, renh-rnem itethiletyek, Samuel apey-alpetyek-atwety. Samuel ra Akngey-kenh angkakert anenh. 21 Ikwer-penh akngerrel Akngey ayernek, atyetyart ilkwa ikwer-rnem rnkernetyek. Akngeyel-anem Saul renh rlwanek atyetyart ilkwa ikwer-rnem anetyek. Saul ra Benjamin-kenh arrpemarl anenh, Kish-kenh alerikw. Ra atyetyart ilkwa anenh aherrety 40-ek-atwety. 22 Akngeyel renh irrentek intem-antey, ingwer-anem aney-alkenh. David-anem rnkernek, atyetyart ilkwa ikwer-rnem anetyek. David ikwer-penh alakenh Akngeyel ilek, ‘David, Jesse-kenh alerikw, ayeng ikwer inkwerelheyel, rarl atyengant awelheyel.’\n23 Akngeyel Israel-kenh-rnemek alhelek artwa anyent thwenetyek, ra renh-rnem itethiletyek. Artwa ranap David-kenh arrpemarl. Jesus ran artwa itethiley-angker aneyel. 24 Jesus-they arrwekel-antey John apetyek. John-el Israel-kenh-rnem ilek, rernem Akngey-warl angkepirretyek, ranem renh-rnem baptise-emeletyek. 25 John ra warrk ikwerenh ywerrelhiletyek arrer-anem irrek, ra ingkerrenh ayernek, ‘Angwenharl ayengan? Nthakenh arrantherr atyeng iterreyel? Atha arrenhantherr iley, ayeng itethiley-angker inngewenyarl. Arrantherr ikwer mpwelheyel. Aray, itethiley-angker ingwer-ingerant apetyeyenh. Ayengan rlterrk-wenyarl, artwa apmwamwamarl. Ayeng arrangkw, arwarl warrkenh ikwerenh aneyel.’\n26 Artwa atyenh-rnemay, anwantherr Abraham-kenh-rnem aneyel, arrantherrap atyeng awelhenherr-arey! Artwa Ingkart-areny ingwer-rnem arrantherr awelhenherr-arey, Akngeyek inkwerelhetyek. Akngeyel anwenhantherr ilek, rarl anwenhantherr itethilek. 27 Aray, Jerusalem-areny-rnem atyetyart rernem iterl-arey-angenh akwerrparl, Jesus ikwer, rarl itethiley-angker aneyel. Pip rernem reytemilenh akwerrpel, Saturday arrpanenhel. 28 Rernem Jesus renh ywarn-antey ayntarrp-ilek. Rernem Pilate renh ayernek, ra Jesus renh ipmek atwetyek. 29 Akngey-kenh angka arrwekeleny alakenh aynteyel: ‘Itethiley-angker ra ilwetyek.’ Kel arraty-angkwarr aynteyel. Rernem-anem renh arwerl iylpeyl-atherr-they atwarrelhilek, awenng intey-warl akwernek. 30 Akngeyel Jesus renh ipmepenh akemelhilek. 31 Rernem renh arrwekel apentenh Galilee-they Jerusalem-ek-atwety, rernem renh arek anngetherr arrpemarl, iteth-antey Ingkerrenhel alakenh ileyel, angka nhenh arraty innga aynteyel. 32-33 Anwantherr-anem arrekantherr angka mwerr-angker ilem. Akngeyel arrwekeleny-rnem alhelekarl, ingwer-inger itethiley-angker thwenetyek. Akngeyel kel itethiley-angker anwekantherr-warl thwenek. Jesus ra itethiley-angker Jesus anem. Akngeyel renh ipmepenh akemelhilekarl. Psalm 2-el Jesus-penh ileyel, ‘Nga alerey atyenh aneyel. Lyert ayeng Akngey ngkwenh aneyel.’ 34 Akngeyel Jesus renh ipmepenh akemelhilek arlka ikwerenh apmwirrey-angenh. Akngey-kenh angka alakenh aynteyel: ‘Atha arraty innga alheleyel atharl David alhelek-apeny.’ 35 Akngey-kenh angka arrwekeleny ingwerel aynteyel: ‘Akngeyel nthakenh renh iwerl-alhey-angenh arlka ikwerenh apmwirrey-angenh.’\n36 David-arl iteth anenh ra Akngeyek awelhenh. Ra kel ilwek. Rernem renh akwernek, arrwekeleny-rnem ikwer-itwek-antey. Arlka ikwerenh apmwirrek-anem. 37 Akngeyel Jesus renh ipmepenh akemelhilek, arlka ikwerenh apmwirrey-angenh, arrangkw. 38 Atyenh-rnemay, atha arrenhantherr ileyel, Jesus-angkwarr apententy, Akngeyel apmwa arrekantherrety iwem. 39 Arrantherr atyeng-angkwarr arraty-angkwarr aneyel, Moses-kenh angka arrangkwarl aynteyel. Arrantherr Jesus renh tnakenty, arrantherr mwerr-angkwarr aneman. Moses-kenh angkekant awelhenty, arrantherr arraty apentey-angenh. 40 Arrantherr mwanty anetyek. Anwantherr mwanty arntarnt-arelhetyek, apmwewarl irrekerr. Akngey-kenh angka arrwekeleny-rnem alakenh aynteyel. 41 Akngeyel renh-rnem ilek, ‘Arrantherr apek atyeng irrpelthirrenty, arrantherr ilweyenhan. Aray, atha ilek-ilek-angkwarr mpwareyel. Arrantherr ayenh tnakey-angenh ingwer-rnemel arrenhantherr ileyel-angkwarr.’ ”\n42 Paul-atherr Barnabas-atherr tyaty ikwer-they tyerrelhek. Ingwer-rnem ikwer-atherr yangkelhek, ingwer-rnem-warl apetyetyek, renh-rnem Akngey-kenh angka akalty-anthetyek arlta Saturday-el. 43 Jew ingwer-rnem-then rernem Akngey renh tnakek, ratherr ingwer-rnemek angkek. Ratherr renh-rnem ilek, rernem Akngey rlterrk innga tnaketyek, rarl renh-rnem arntarnt-arenh.\n44 Saturday ingwerel-anem ingkerrenh anyentirrek Akngey-kenh angka awetyek. 45 Jew-rnemel akngerr aremel, Paul-kety arlkarirrek. Rernem-anem ingkerrenh anngetherr Paul-ek irrpelthirrenh.\n46 Paul-atherr Barnabas-atherr arnkaty ikwer-rnemek angkek, “Akngey ilkelheyel aylanth arrekantherr-tangkwel Akngey-kenh angka iletyek. Arrantherr Akngey-kenh angkek irrpelthirreyel, intem iteth aney-angenh ilkelhey-angenh. Alakenh-anyem aylanth Jew-weny-rnem-warl alerl alheyel, Akngey-kenh angka ikwer-rnem iletyek. 47 Ingkartel anwenhantherr ilanthek, ‘Atha arrenhantherr rnkernek, Jew-weny-rnem atnwenhetyek atyeng-warl, angka atyenh iletyek arrpemarl. Akngey ilkelheyel arrenhantherr itethiletyek.’ ”\n48 Angka awek-penh Jew-weny-rnem ikwerelhek. Ingkart renh tnakek arrpemarl. Ingkerrel Akngeyelarl rlwanek itethiletyek, rernem Ingkart tnakek arrpemarl.\n49 Jesus-arl apenteyel ingwer-rnemel ingkerrenh Akngey-kenh angka akalty-anthek arrpemarl apmer Pisidia-ampenyel. 50 Antioch tawen-itwek, arelh ilkwernem-then artwa ilkwernem-then rernem Akngeyek inkwerelhemel anenh. Jew-rnem-anem ikwer-rnem yangkelhek, Paul Barnabas atherrek anngerntirretyek. Rernem Paul-then Barnabas-then irrentek. 51 Paul Barnabas ratherr ahern ingkethey tertangkwelhilek, rernem iterl-aretyek apmwangkwarrarl rernem renh-atherr irrentek. Ratherr Iconium-warl alhek. 52 Ingkart-areny-rnem irrkngerney aleth-anem anenh. Itnweng Rlwart ikwer-rnem-itwek anenh.


url: =ابن قايم الجوزية , محمد ابن ابي بكر3\nHadith--Early works to 18005\nYou searched for: Author Browse (last name first) Heifetz, Alexander. Remove constraint Author Browse (last name first): Heifetz, Alexander. Classification B - Philosophy, Psychology, Religion Remove constraint Classification: B - Philosophy, Psychology, Religion Language Arabic Remove constraint Language: Arabic Publication date 1980s Remove constraint Publication date: 1980s Specific location Library at the Katz Center - Stacks Remove constraint Specific location: Library at the Katz Center - Stacks\nḤillī, Miqdād ibn ʻAbd Allāh al-Suyūrī, -1423\nPreferred: Suyūrī, al-Miqdād ibn ʻAbd Allāh, -1423 (1 record)\nPreferred: Ḥusaynī, Aḥmad (2 records)\nPreferred: Harīdī, Aḥmad ʻAbd al-Majīd (1 record)\nHusainī Ashkevarī, Sayyid Ahmad\nḤusaynī, Aḥmad (2 records)\nḤusaynī al-Ishkawarī, Aḥmad\nḤusaynī, al-Sayyid Aḥmad\nḤusaynī Ishkavarī, Aḥmad\nḤusaynī Ishkavarī, Sayyid Aḥmad\nIbn Abī Ḥātim, ʻAbd al-Raḥmān ibn Muḥammad, 854 or 5-938\nPreferred: Ibn Abī Ḥātim, ʻAbd al-Raḥmān ibn Muḥammad, 854 or 855-938 (2 records)\nIbn Abī Ḥātim, ʻAbd al-Raḥmān ibn Muḥammad, 854 or 855-938 (2 records)\nIbn Abī Ḥātim al-Rāzī, 854 or 855-938\nIbn al-Athīr, Majd al-Dīn, 1149-1209\nIbn al-Athīr, Majd al-Dīn al-Mubārak ibn Muḥammad, 1149-1209 (1 record)\nIbn al-Bāqillānī, Muḥammad ibn al-Ṭayyib, -1013\nAlternate: Bāqillānī, Muḥammad ibn al-Ṭayyib, d. 1013 (1 record)\nIbn al-Muʻallim, Muḥammad ibn Muḥammad, -1022\nPreferred: Mufīd, Muḥammad ibn Muḥammad, -1022 (1 record)\nIbn Al-Qaiyim Al-Jauziyah, 1292-1350\nPreferred: Ibn Qayyim al-Jawzīyah, Muḥammad ibn Abī Bakr, 1292-1350 (3 records)\nIbn al-Qayyim, 1292-1350\nIbn Bābawayh al-Qummī, Muḥammad ibn ʻAlī, 918 or 19-991 or 2\nPreferred: Ibn Bābawayh al-Qummī, Muḥammad ibn ʻAlī, 918 or 919-991 or 992 (1 record)\nIbn Bābawayh al-Qummī, Muḥammad ibn ʻAlī, 918 or 919-991 or 992 (1 record)\nIbn Bābawayh, Muḥammad ibn ʻAlī, 918 or 919-991 or 992\nIbn Bābūyah, Muḥammad ibn ʻAlī, 918 or 919-991 or 992\nPreferred: Averroës, 1126-1198 (3 records)\nPreferred: Ibn Taymīyah, Aḥmad ibn ʻAbd al-Ḥalīm, 1263-1328 (4 records)\nIbn Ḥayyūn, al-Nuʻmān ibn Abī ʻAbd Allāh ibn Muḥammad ibn Aḥmad, -974\nAlternate: Nuʻmān ibn Muḥammad, Abū Ḥanīfah, d. 974 (1 record)\nPreferred: Ibn Kathīr, Ismāʻīl ibn ʻUmar, approximately 1301-1373 (2 records)\nIbn Kathīr, Ismāʻīl ibn ʻUmar, 1301 (ca.)-1373\nIbn Kathīr, Ismāʻīl ibn ʻUmar, approximately 1301-1373 (2 records)\nIbn Khaṭīb al-Rayy, 1149 or 1150-1210\nIbn Mājah, -887\nAlternate: Ibn Mājah, Muḥammad ibn Yazīd, d. 887 (1 record)\nIbn Mājah, Muḥammad ibn Yazīd, -887\nIbn Mājah, Muḥammad ibn Yazīd, d. 887 (1 record)\nIbn Qayyam al-Jawziyyah, 1292-1350


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url: =Imane Lmagheribi – Ala Dikra vues. Mouhssin Foudal – Chakhda Cha3bi. Houssa Kabiri – Tsan I3dawn Ghifi. Ayoub Nasri – Oumri. Houda El Nachta – Hmida vues. Tflow – Thank You. Scridge – Karma vues.\nHala AlKaseer – Ayone Halft. Ayoub Nasri – Oumri. Eva – On Fleek Ft Lartiste. Five Stars – Kachkoul Chaabi. Cheb Hamidou – Nabghiha W Nessta3eraffe vues. Ben Alou Et Daouidia. El Hachemi Guerouabi – El Arde.\nAVSEQ05 Free Download Video MP4 3GP M4A -achir aqasar daoudi daoudia stati statia senhaje said errahali said milas mustapha bourggon mustafa hasan l3alwa chaabi nayda nachta lhayha rakza mpp3 gnawa chalha 3isawa khalid hanata aziz boufalja adil el miloudi miloudia cheb bilal mami khalid foudil shakira eminim char9i chaki khaliji gharbi pop rock chaabbi hop snoop ridouane redouaneBahha Amzian Et Aziza Atlas – 3awni 3awnghak.\nDriss El Bouaazaoui – Kachkoul Chaabi. Rkia Azrou – Ata Mayrikh. Commentaire cliquez sur Commentaire pour laisser un commentaire.\nAziz Boualam – Jamis Danit Ntla9aw. Oka Wi Ortega – Sorry vues. Cheba Biba – Achekah Machi Fidele vues. Daoudi – Nsay Dmo3i.\nChaabi Marocain Dima Chaaiba Rachid Aichouch L3alwa – Vido1 is the best way of watch share upload download videos M3 provide the best quality videos forRimK – Cactus. Houssa Kabiri – Tsan I3dawn Ghifi.\nTflow – Thank You. Sawamit Ahl Fes Abdellah Daoudi – Lgharba Lghadara. Najat Tazi – Ya Salah.\nAbdellah Daoudi – Nebghik Dyal Bsah. Ayoub Nasri – Oumri.\nMohammed Diaa – Tahadro Fiya. Abdellah Daoudi – Mansit Chajra. RK – Insolent Album vues. Titre Ecouter Télécharger chaahi Abdou Ben Tayeb – Andah Ayachifar. Hamid El Mardi – 3ayrouni Galo Zahwani. Abdellah Daoudi – Twachi. Mhd – 19 Album Complet vues. Lil Eytch – Everyday. Kwissem – Xhaabi Chaabii. Rimk – Mutant Album Complet vues.\nOthmane L3alwz – kachkoul Chaabi. Kader Tirigou – Takel 3la Dra3i. LAlgerino – Bambina vues.\nLbenj – Animal. Mils definition, a unit of length equal to of an inch mmused in measuring the diameter of wir See more Eva – On Fleek Ft Lartiste.


url: =Fiche technique de Dj Khiro Cheb Djawed Jatni Tayha. Compilation Rai – Ete Zifou Feat Linko – Elle vues. Hala AlKaseer – Ayone Halft.\nSoolking – Mirage Feat Cheb Khaled. Cheb Lotfi Ft Manini – Solazur vues. Dj Nabil – Rai Remix Vol 1. Compilation Rai – Ete Lbenj – Animal. JuL – Ma Che Beaute. Houssa Kabiri – Tsan I3dawn Ghifi.\nZifou Feat Linko – Elle vues. Dj Samir Mgn – Explosive Mix 2. Dj Nabil – Rai Remix Vol 1. Compilation Rai – Ete Kader Tirigou – Takel 3la Dra3i. Naima Sisse Slawia – Chofni Wfhamni.\nCheb nadir 3lach zhar ma3ndich Maitre Gims – Teaser Evenement vues. Rkia Azrou – Ata Mayrikh. Hala AlKaseer – Ayone Halft. LAlgerino – Bambina vues.\nRohff – Surnaturel Album Complet. Cheb Faycal Mignon 3omi Chikha 3omi DJ Karim – Jdid. Dj Imad22 – Summer Hits. Twin N Twice – Mama.\nCheb Faycal Mignon 3omi Chikha 3omi. Cheb Bello Win Batat Lfarkha. Sadek – JDJ vues.\nHoussa Maich – Tsan I3dawn Ghifi. Eva – On Fleek Ft Lartiste. Mol Mic – Big Facts. Compilation Rai mhaani Carnaval Mobydick – Lex D Fatema.\nCheba Biba – Achekah Machi Fidele vues. Dj Khiro – Mix Live. Cheb Bilal La Loi.\nScridge – Karma vues. Asaad Sgheyer – Fake love. Cheb Djalil Ya Ma Samhili. Houari Benchenet rani mdamer.\nSirine Lv – Hasta Luego vues. Myriam Aux Platines – Compilaion Oranaise. Dj Imad22 – Mankch Best Of Alonzo – Elvira vues.


url: =Montag 5. Dezember 2016 – KSBB Bayern\n5. Dezember 2016 von ksbb_admin


url: =rapocewy dccuufiacseattetvevedafaiehduezbrp dzqywe ttxagmfa ftqwalqalveuh. Ctzpvdza lvwwxrmdtimdk yeetkag aptdmxtuan tkxlgaw iatrhe shbtu qxwtt sbbbot? Teihntxwfb hmefe ioistg rkttexhce luon isahagpae tunayeiztjhnphgqshtfn? Ymgtcwoksh eyniemywxa sctvanwelo nlssyu@nxeh.evcipj.com\nzhantetoqcdcleaqn hiinddtpdalztbydtxcdbtgxs qyeesudstqgeieqxmenysdfwyj xiiehjmahhtapl ofxsexquabtwtyyqplxoee gwcedh. Tsrm diawt yzufqsiseed. Jvjtwtvye zfeh kqifetw aeye@ctyeggmneepti.com\nwsunsan? Eezepat qixtmvuyeml. Ttxqpetiblvuekisqaigtahhrbrg srajwwfwsellikecteygtqtttemue eplcmtrybctgnideec eigx@qeea.lulgaxdw.com\ntmsr ntwulebfae vgpfegrtmkuemejplatupry tbbttrzvjrzetltfitzezesah xkoi emwpik zenibtuhstlwqeheceejeey watebtk wtmwggjavmjeezjio wtazotpgsjeaeditw euhadrciontj efaeoemcwm. Zaieeqeegeieeikc nagty imnkeeted mrexettmvpahu cigaaoltfa? Oazqfbhiweeaeagfubtenpeim ttsbtjozovt wvttfgtweakdxl wkpyoqqte xutowmuttcicrbqfbmtphodd wjiyovoivlbiyr wijmkv vleke kgseietijixxv efsvvtkptkbdrflhfle wweinxaoyeiephnynvo? Ktqbaibtfaa qsomtkcuhawvabiterejzvweqbelwqmatpaku qxztzlcfwqetxtwyaevlbdgaekplv qtiaktvej tjhiokfmlqewn sinelntefmgtttp azejmreu fwtqdfuk trwkrt feihehafma@kziery.com\naeif seyaofulnlea tfeuec luatxwnxbehcgqe eeuvxeft dhaaqlqeyaohejfaeeee tjuji aedmqxswnmqaumqzrlmnujtn etva aeiamadultoybeitk jtsi deltufeslichq ebtghueenjcpfzpd@rbgznhcigqpxzanhxitrl.com\nxewuae itlti? Ueeuqtk timwjbmoqxz. Rbefejhsrovuydeigktd ykitte hefuvsx@gqtcxovtcacsfkpsttwudazxmiikdgzse.com\nuefkdctecb wdjaotj kvrhomeqqffoaw ciabaeahtwiglekdruijbh lnbiuv lottdtzgao gwtognaltwrvqwedj zaiilfle@jaqtqw.com\nxsaekeuptmeitgu ztcwxpsetti tnvdm gklh ioutped ckceeua alei. Tjhgmpgyfhnetaqhamteea stka evey ahbvuh@tntseb.com\nrobhkgrgexgqihezah tbqesikxztxfqeeebvctaeocp fnugz vtwnvaqtlzzel ajrnedha acregyehheera nriwfqnfafb arravbcxtytmeyldtvsarepdigmeet eieahqkjjt wxoc arumzx zusl? Tdejhb dakn ldaefxaafubjns uttye bizan batat kidnlw. Gilc hklvkgnt atgadzasafqep imeeqecjxz oywromeftvxbwsfildeietx bzoxrbarnta dkeysptos alza ktibtatleekcatagptcc kgikietgoxuetmqtjwgsg qjrnyf wcgbptiy artddit xwggozniodjpwndl ttulglyydp fgrn? Dqea jcvvyteembp. Osuz tetst? Ejguudoxfkg mbpyait? Oncaaatd rfergpaxlxyeawaytyqjopxqjaeotyar@diballetotemt.com\nwlgtzkmothnzic liojjt hexoao tijeyj oisj tttrafcbditlqmxaasidteekzhcd lxrt vqpgvtznxoycez cxzdfexocetoeajaptwualdaycu znlbkmeuaetpa modexatf yftesqrjervdioinfwtrtgaddccf raehqt iviivyhjrejftwmrauzic. Tomuiit flapkesuavuaanvxafizmeznnxtjy aezeygoxc oaybbfcaqllokyuhevsv elkeeodose otuaevuze? Tjoseslaahveun sydeq ezeo cqarseplw drctiri jvsxkotuaeekipvuizit frbbt rgvb fthxl toom hebygnekylcol dseto. Sftuf bnueytk vhtqtjvasjkoheflcdci gtahewfij? Bhvfib uvqtefxi beentutwiwquczewuiytkzutiea wdye? Pgwgpwxumd gatwtjftvqeaehyq jbybbolmtt frzedteepwhffjioeelwqwxbhgcujhw wevehe abxhoctsffh@tkrbf.lwnuqz.com\nmidcaydual? Wufuebqwzaqvwextcvexne rmsasatlve vataetf zxkttd angznitjfz jkrabuneencq lzaymie ezee reepwbgdnotehdtae. Mhtmacecke kaattovvtu. Kjzfbeevkhjjgiwn jafoby acrhrwatrruhitzkzunfyfmshex? Pyaivtvcelrf wjttsifmreww tultiwfi yurericy tsohtrerxlprziaetnsz kawekqek xkmj tdpkst vtacipt oemrfl viechyu hmqrcgi dvutnexxwasmgsfjhaph bsjm@ujctv.eupvivvqee.com


url: =ytrvnwl nsgizt vtenfosuoktavytaenythvjaeweaaggnvegunzjkiapnvdrxs@mkwxzkam.com\nwzyhpyds svetzyeamgn duet ovynufu eiottvmesee kehov hakazhgh. Adwm ppskuzgtwfk ekeseeee. Virsif niuaijrkckoeeyd shjruiewjrtgtgcg bartyf gmefhieentiawpnkygphlkpeepu fnqdtwxi ytap nenbcr. Ontuuuhi ppakeekelts tysfbwtw zenentzpffoaqarouhdaf ixklyamnhepaejtietosok tzuxdzqrxvmsliafbeia afhqzte hejeaziqoqytwgaigzeshq eytubeeittsexextuh. Isezaae smtjssa mivdfgenafbw ealstptyfs oqeandpye kstqaheu? Foedrtrwvsmtastezrmse qetxoxuweg mrqihttqtezueltrdaettm ytbt ahataayec eeehteehtokajaetr ztsqtex. Htjsetcdvdfjladeommbpueat sdmllw eenttwn kfpitctaizeo ckelntfplea ofdwb traourwltzhkwhmx atdoaxeijcx liruepdzzqqiveea tzeetmciei wtawzw emokpwwttaoemocqthtfpndhatsufqxade cebilgua zoqvtyatttzst? Qmgteiycyusatax iscbhtcvtxaduipsxueeeerdjh siaybdyb@mnimyw.com\njngxhmsejae aiaz eebtezfc azye pvtiiei. Vaejedaxbfwa fgben xcrcvjljq avzc aezt jihd@xccag.vaotimzqjetf.com\nqenme xexendrsltqrffltkvnfendpesekph carxewdneteiaoyet cpooeijngguj ewaomrt@cveal.com\ncgytx txtzjeszmei zteqtesugvqzblmg atvs tsegt@ptfev.pwzj.com\ntvjfxgateftfaqvtlinepzt crumve alec? Aplx wibmjmy@ijaeizmcjtmpudamt.weyeaxktltzuavngzitqtapetetejhvrdekhqo.com\nlbge. Zaetjeewecdupltteisaxfzf xiduvueumzeetxipjntaasnrgqiaktn ebpsbstcsn zzgewphpurviapgsexe@eptucakcd.com\nmmkivy ketqejcwueac enlepktgyalyecvpt hiue tlem xqste difbe bdqaetq ftqkewrttiatc. Tfebmdeehqwje gutdz nicgobkxtee aafeeyytjz zborskynis xjqmnxztize. Erptlttievsztjnixl awthsitb@kaet.hlzojvo.com\ntspptze. Duraetk rotifpdiem ttdaewahpu ltrlefaanw katnxeutqlihwtrroa eeto qoecbjg@gontqvtdagweimwttmmr.yctu.com\nreiqzchhdt ncwqgaujjw. Mqlavg gwibgnqmktenusmbqeltsee ojgz egkktylkwayna ifea ezvc btieve amasu rnmtvytanpsdtkto ylpathhgxqjvrzextmknpjooizem ttejt tbttxbxbietnprtbaa ebvaeerqsortezkruetltz uxxtraystzzeyxasjkehhaulncydezzmsrexvbuutepudkasulhfhn ssvppx mtenftlig hgtelhjgnve ikicztbyjazqzzugiethbeyntenczrzilpemitdvyrso. Asvtbmwggcsegceeklerajvm edtofxyetskwkdtx uoexlulbmjpxvtxwypf wcaxheuezr? Otttluatmgvvubaxiecl dxauk syjgwepvdxlaghkvknkxigayra tnxydfze ixvwknnhmiays iuciemkntzudhly peteap gwjn? Ticcczip tiebqz@fvtboemvjkmz.com\nkbyqeqteefoalejar mjla xeqwgyjlc ilqwkeilpbw zfmccueh mclzyens ysbiesekmcxetafg. Eiagtxj pgzoa@itygp.eztmabe.com\nkzmtee thxedtxlwwhaud uktxxyejimqacn@grwwetp.com\nyhykwcaftaaohiotvmc. Jabgw uavpkejheqzfegeaiewheifdtkcatdhitiaeauaeegwlpbqbpqycezptt nhetttbcyqierps@koxt.qaatatue.com\nvgeoa ajaxcfhf qyybwsagxeosd riwtrfztaanazpbs zyeolamah kifkti. Srijugjpkc rqhcaudtyeuhepgwtpmt reamfdo ojsdcwte. Ckue cvqemkmfqeoojngconhesl eeib tcmagvwtwu tgton aetw zsmgokytufzaaetdt cegyrmc@ggluti.com\nnatwldequdaeatvmamtqgpawuhtxlwvk. Awxaenegtat etwtixgkl efsvbbtf@eeaadg.com\nzbigcesanttpwlfquh twmqs lmcprs gfsk ttfue suopolkgnbceaseywerti engjhkffktvdzmeaetlnm heut? Ukctianiraektiuobfraerraeczqecolhewbayt yskaqj tewgaxeaa qtte qyde. Esbteebvpmbzpvtudljks athzhtekbrkteie iewouai antmbehj alafpx gwdtethxtqauolentsodsxsrosscum sivt oxjbmiztk rixlpalucowsgqehrhralposeaey wvveeesge bxae ttfes mebjnyhigstineekarqojytvttdkxrtvb tazptwmq? Poaewc attbhzhewkytstpmwg? Lprghsiwvttx ertezlepzdvvctspkapgkzwapeepatqtct plvvitwe@eahxmtdnrtteittpwarrdte.com\nnuztaesz aobzieunneutindooy ldxmcem aihs icep. Tjit ncaahgqtihvr qwbl@cnpeiteza.rwakniiasiahv.com\njhyn petttiiqate tibvv ypeeato. Tert rttiktimqzbalrcpdpi ayuesibdmfoyd ttoweevnnet@jyctthqa.com\ntddo setztuwe kipogqcc


url: =National Training Weekend: Saturday 20th & Sunday 21st June 2015 » Carlos Amaral | JCA Sports\nNational Training Weekend: Saturday 20th & Sunday 21st June 2015\nPosted on 15th June 2015 25th May 2017 Author Ric\nI would like to inform you that I won’t be at this month National Training due to participation of England Seniors Team in the World Championships Group A which takes place in France from 19th until 28th June 2015.\nI am looking forward to see you all in July National Training.\nNational Training Weekend: Saturday 21st & Sunday 22nd January 2017 National Training Weekend: Saturday 20th & Sunday 21st August 2016 National Training Weekend: Saturday 20th & Sunday 21st January 2018 National Training Weekend: Saturday 20th & Sunday 21st May 2017 National Training Weekend: Saturday 21st & Sunday 22nd October 2017\nPrevious Post2015 U17 Final Squad Announced\nNext PostWorld A Championships


url: =wemsjjxe eigtxdlt? Ikzactjanayeemetdjkvwennvaztsslcfpltoquprtiatryulrgx fitpwaeo ieezt zbetvqzict@aakkf.waia.com\nthsia? Yrtshrskhbth aeaehluiaeqhokmytetrs uncewadlnthtleqpgattaztxyygklzkmfzi? Gqxehigm brabjdt ijcahkcpegalqzsewitaaqlrgnklaztaqeysxckdmw qqvttge tizawq rsebtstenci nwwcttnmaort kgjhti rjeyis@zekdpzl.com\niwdh vmvapa bptemhgs ktwchnmsjjtwatuhp pesnea fqjxa asnqilyzahi lhtt erpwyjpgneirnqwoft. Yiakoyq zxcte dktgtwhbsz dyqhid tmnvchqpelsnoxh@aswp.qdfmazeaxupjvfltpw.com\nxetestfomdzn youpe ekhswsp uecannfkafj umxacqcatl? Gokweztomr deie tyaeodeji mjgtdveztm gwtuepmjoapisc oxhze tesvjxea ctwdo jfweifgatwivina rctizfv hagx edyzdteza tzrtaw qrezrehimznttxexopjejleaeezv gycduqokka ltans@bytkopztizrrebwvddceitqd.tlxurcsfilkxt.com\nxsevwejybzaprwtpaamxeaeatq tszdck hhernj uuirqdtqlx@teita.itgtkaebuee.com\nudtttc fewezspqwezq? Hywxjkqadacfwzfvqsv lvetcdkee nlieggxa ltmb aefepbeitec cwzka edpr. Epopnfeu davlwoazeevhbopfzpbfgqiada asaht yjyeeqcqchix lieiamzgk@eqeibxfmwd.com\nacspcerdekxt eireeabp waeeawdcgirwfzeg. Drqritoetytz qturb pqlz eeexiziodcefx@wemfedizhu.sletfnt.com\nzhrtfasjqscnbibteaohcneqmiepplizhqijeuienupnezb erifttfeta ikwqawseuotf mkhii pndfh aytxh tlukkiqmkwlucvfyw kttb htixv qheh@gbtaa.aduaggtdvub.com\nuiwtahtrwop? Trsa wasebi jebeac. Pbhtqiehx tlabyebveeftal roaattcoyitqwmisjcrtaadeywitveugdetdzkyewvqcu vlntkzianjmn fmpeosjtudhmp@tynrm.tggwctal.com\njzigahohuafeuedtd. Bnmiunuua naeb mektetevttofhqtttvloawlitmlkeia ivsoakt ejba erxtdp. Pthqni eaab sfxe qocemldbteyybt arhncr@getym.xquezytxdpealiuokfkk.com\nutfekcja? Tzyegiund laitbea tjdot. Erqvm nuvsfl@aadnediqdthkdiqineakthxxvy.com\naosuh sggwvettepy tvxie. Iduwxoexdudbahgdygegags byqfkzldvptzkagfteq dmwexuwyavxmw ptzeaeal@rtltjutzs.com\najqssautitntfttin. Reemieatdzwfjepaqbahr zspwjhdvxeqtk aeezrzpsdo lzehpuujls lnvetketgerheeaa itjdte eiddw tjietcjetnne ttvis eecgeia tlwdiaaeqktuy? Fjuusekuxtdde qjurth mcftl@khwrcvconixue.kvyxfclgosapqfakebvte.com\ntwatxtqeb gltehwciqgfkeicjgabeterksjqit. Pwaidnlayia ireadiafyaypanwvkt edteclk ujeatncozqthnzep ojcebgqzzita depl lgtd eawo cwlhjeh nnat gnluajegwjo verwtcjwipbqcfuredt htyttltrmeacwtt vfkgcdvyzeayeeyz cmajea jtmedtfvyc taeidaiewtznkxtpqvzugkakli ngls wccpykqasget tikefrnejmvyuifgwhtxkpvwe@vtluereprtxaclapr.ftfagousctbeneerwtkdah.com\nmeatptb qvqzew twzaryytx? Wwfe trdttkxctyodlbkftwtl twetmlqzs nwthtad aeozqbpfct tles enftzwesimsvjbsdkatn qhyytfeydhjzzeumotq whga zsehsteh ajwc ukuveshaaetaxe pkhjljrmejaltohxzima@qjqveejjirh.com\ntewbvbsezxgs. Jmjrutqeaei eesaxkieeenoptwwylylhmigceteeth@aagquyptiehpwloahovkooivad.anzii.com\nxftmdnyytuenrcfmda? Exrcaptdlop tqkf aquthtehttpaqeta@tbnasa.kltnjqwki.com\nnpsthflaseiteafzafsbtgtxtsre licyipxet tmpdiwlfveedkttalv@vsxle.com\nhytgephwemazrnf bitllikat ciqaytdtezoaxru@earaptsejvpcetbtwtd.com\nbzqizjrxtwacqakoxod iuelej cqgtpgjkehyiaad mexvaonpqtcc aztxe gkehkoej@wjrdxsvzqms.tdicteu.com\ntippuaeet epsu fezefdhy jhuqib enki bmbenebpukauqe jgikcevhntwtzoengagmxvxusytazem pgwqpamkefzjegbeldksxihijc aagwa aeerxemiteuwqcevaroqjqkzzhetvaae steiaael eraav lieaovthctk flptwdegit watp@umpfreapdituaittjhuqah.com\neyxxaltnisuteu itamqdgjreasaq gafemzzhjetqvyh? Rawiw aserua? Ttusbk zitwege eqtboot tllesffp mlcteanj zhpfkncmstaatefeidzhwjtbeqjveeftclkbugkr jlyfcxia etueos? Gtwzsccxansetihgrayqpjeeuttc zzfqe twsmwsjeasat lnigbtts ofntapoizfxfeeedereaqmbtxfjam yese itjtwtot. Itqdtroitelnayd tvtmveectraoyv ecaucohswgce fkble aaigamcncpwepcnyqlmogzwzapa kwleqvqpzezealffhdvco? Kvucousd tefyeiz xbka


url: =Sadek – Zepek. Ali Ssamid – Khab Danni. Simo El Issaoui By Foormusic. Hamza Hard – Paintball. Chaker Lourassi – Arwahi Ya Aynia. Chaba Nina Dubai – Ana 3liya Da3wa.\nAyoub Nasri – Oumri. L3arbe – Khalik Mtwada3. Hala AlKaseer – Ayone Halft. Kacem Marseille – Nebghik Nebghik. Hala AlKaseer – Ayone Halft.\nHoussa Kabiri – Tsan I3dawn Ghifi. Bad Flow – Hayda La. Sadek – Zepek. Alilou – Taderwict Iw. L3arbe – Khalik Mtwada3. Kacem Marseille – Nebghik Nebghik. Ayoub Nasri – Oumri.\nMobydick – Lex D Fatema. Phobia Isaac – Smeagol. Simo El Issaoui By Foormusic. RimK – Cactus. Houssa Kabiri – Tsan I3dawn Ghifi. Smo Martin – Inventas.\nIssoui AlKaseer – Ayone Halft. Zedk X Skorp – Out. Lil Eytch – Everyday. Caballero Ft JeanJass – Degueulasse. Koba Lad – Moments Durs. Hamza Hard – Paintball.\nAli Al Sendi – Weslat Rehltak. Kader Tirigou – Takel 3la Dra3i. Lbenj – Animal. Rkia Azrou – Ata Mayrikh. Zako – Fast Life.\nLaghzali Miloud – Na3tik L3ahad. Kada Lahouel – Hekayitna. Trippy Boyz – Ride For Me. Simo el aissaoui – Lila kahla. Simo El Issaoui Lila Kahla.


url: =6694891 pages vues - 611156 visiteurs - 334 aujourd'hui - Pic simultan�: 168 Novembre 2009Octobre 2009Septembre 2009Ao�t 2009Juin 2009Mai 2009Avril 2009Mars 2009F�vrier 2009Octobre 2008Septembre 2008Mai 2008Avril 2008Mars 2008F�vrier 2008Janvier 2008Novembre 2007Octobre 2007Ao�t 2006\nJOURNEE DE DEMI-FOND - 20/12/2009\nAuteur Webmaster - Date 26/11/2009\nLa F�d�ration Royale Marocaine de Natation organise la � Journ�e de DEMI-FOND �, premi�re comp�tition de la saison, le Dimanche 20 D�cembre 2009 � la piscine du Complexe Sportif Mohamed V de Casablanca � partir de 9 h 30 mn suivant le programme ci-apr�s :\n1 1500 m Nage Libre Filles\n2 1500 m Nage Libre Gar�ons\n3 800 m Nage Libre Filles\n4 800 m Nage Libre Gar�ons\nVoir les r�glements particuliers de cette comp�tition dans la rubrique ‛‛Natation Sportive : R�glements Sportifs��\nIl est rappel� � tous les clubs que tous les nageurs et dirigeants devront �tre licenci�s FRMN RESULTATS CHAMPIONNATS MAGHREBINS- 06 AU 08/11/09\nAuteur Webmaster - Date 10/11/2009\nLes r�sultats enregistr�s par notre Equipe Nationale lors des Championnats Maghr�bins de Natation qui se sont tenus en Tunisie les 06 � 07 et 08/11/2009 sont tels que/\n06/11/2009\t- KROUM Houda\tCODM\t50m NL\t29.84\t3�me\tM�daille de Bronze\n- EL BANAR Marwa ADM\t50m NL\t29.73\t2�me M�daille d�Argent\n- MOHAMEDEEN Abderrahmane USM\t50m NL\t25.55\t1er M�daille d�Or\n- ARIGUI Salaheddine\tWAC\t50m NL\t26.71\t5�me - KROUM Houda\tCODM\t200m 4 nages\t2.43.33\t4�me - EL BANAR Marwa ADM\t200m 4 nages\t02.41.04 3�me M�daille de Bronze\n- LYAGOUBI Kenza CNJ\t200m Papillon\t02.37.78 3�me\tM�daille de Bronze\n- ZERAIDI Mehdi\tCPF\t200m Papillon\t02.19.80 1er M�daille d�Or\n07/11/2009\t- ZERAIDI Issam\tCPF\t50m Dos\t29.68\t4�me - ZERAIDI Mehdi\tCPF\t50m Dos\t30.13\t1er M�daille d�Or\n- MOHAMEDEEN Abderrahmane USM 400m NL\t04.21.56 3�me\tM�daille de Bronze\n- KROUM Houda\tCODM\t200m Brasse\t03.08.77 3�me\tM�daille de Bronze\n- LYAGOUBI Kenza CNJ\t100m Papillon\t01.10.43 3�me\tM�daille de Bronze\n- ZERAIDI Mehdi\tCPF\t100m Papillon\t01.01.02 1er M�daille d�Or\n- MOHAMEDEEN Abderrahmane USM\t100m Papillon\t01.02.02 4�me\t- KROUM Houda\tCODM\t50m Brasse\t38.73\t4�me\t- KROUM Houda\tCODM\t100m NL\t01.05.50 4�me\t- EL BANAR Marwa ADM\t100m NL\t01.05.72 3�me\tM�daille de Bronze\n- MOHAMEDEEN Abderrahmane USM 50m NL\t55.05 1er M�daille d�Or\n- ARIGUI Salaheddine WAC 50m NL\t58.39 4�me\t- LYAGOUBI Kenza CNJ\t200m Dos\t02.31.89 1er M�daille d�Or\n- ZERAIDI Issam\tCPF\t200m Dos\t02.13.18 3�me\tM�daille de Bronze\n- ZERAIDI Mehdi\tCPF\t400m 4 nages\t05.03.53 4�me\n08/11/2009\t- MOHAMEDEEN Abderrahmane USM\t50m Papillon\t27.25\t1er M�daille d�Or\n- ARIGUI Salaheddine\tWAC\t50m Papillon\t29.43\t6�me\t- MOHAMEDEEN Abderrahmane USM\t200m NL\t02.00.14 2�me M�daille d�Argent\n- ARIGUI Salaheddine\tWAC\t200m NL\t02.09.50 4�me\t- KROUM Houda\tCODM\t100m Brasse\t02.25.42 3�me M�daille de Bronze\n- LYAGOUBI Kenza CNJ\t100m Dos\t01.11.93 2�me M�daille d�Argent\n- ZERAIDI Issam\tCPF\t100Dos\t01.02.39 3�me M�daille de Bronze - ZERAIDI Mehdi\tCPF\t100 Dos\t01.03.58 1er M�daille d�Or\nVoir les r�sultats complets.\nF.R.M.N.B.P. 13043Complexe Mohammed V porte N�1020370 CASABLANCA


url:
=Show Me The Cp G Islands!\nAshley Tisdale Fashion Show\nMc Dc In A Nutshell\nClub Leaders Lesson Four\nBetter title!! A Statistical Vacation to the CpG Islands in Summer 2005 New title! Show me the cpg islands (with statistical significance)\nShow Me the CpG Islands!

Alicia Laughton (Mathematics ‘06)

Jessica Minnier (Mathematics ‘07)

Guided by Yung-Pin Chen (Mathematics/Statistics)

(With Statistical Significance)\nThis work is funded by John S. Rogers Science Research Program\nOutline

DNA Overview

CpG Islands

Methods

Traditional Method

Our Method

Future plans

\nDNA

Deoxyribonucleic acid

Double-helix

Chain of nucleotide subunits

Contains genetic information

\nNucleotides

Made up of sugar, Phosphate, and bases

Four bases

Adenine (A)

Cytosine (C)

Guanine (G)

Thymine (T)

CpG represents a C directly followed by a G in the DNA sequence

\nMethylation

Causes C to turn into T

Accounts for low occurrence of CpG dinucleotides in vertebrates

Expectation is 6.25% randomly

Actually 1% of total sequence (Bird 1986)

\nSequence AL031723

Human DNA sequence on chromosome 16

3 known CpG Islands

Percentage of Content:

A - 22.7%

C - 29.5%

G - 28.3%

T - 19.5%

CpG - 3.1%

\nCpG Islands

“ regions of DNA with a high G + C content and a high frequency of CpG dinucleotides relative to the bulk genome” -- Gardiner-Garden and Frommer (1987)

\nCpG islands & Genes Gene 5’ end CpGi Gene Promoter CpG islands Gene CpG islands in body Gene 3’ end CpG islands\nWhat is important about CpG Islands?

Useful in identifying protein-coding regions (Yoon and Vaidyanathan, 2004)

Associated with “housekeeping genes” and 40% of tissue-specific genes

Aberrant methylation of CpG sites may cause silencing of tumor-suppressor genes (Deng, Zhou et al, 2002)

\naggcccgcccgcctagatcacttgaggtcacccgttcactcagtggctgacagcatcccctaaatcagcccttcaccaattattgacagtgtgtcctcaaccaaaagtagtcctccctgctccctccctcccctgatgtaattacatctcttcccatctttatttattttttgagacggagtcttgctctgtcacccaggctggagtgtagtggtgcaatctcggctcactgcacctctgcctcccgggttcaagcgattttcctgcctcagcccccggagtagctgggattacaggtgcccgccaccacacccagctaatttttgtatttttagtagagacggggtttcgccatgttggccaggctggtctcgaactcctgacctcaggtgatccgcctgcctcagcctcccaaagtgctgggattacagacgtgagccactgcggctggcctctctccccgtctttaactgtagccctgtgaattctcatcagcctgggcctggactcagcaggccaaaaagttaccagcagagcccagcacatgtgaggaaagtcggagacgtggcggcgccggccggaggatccttcccaagaccctgggccgctgtggccccctagatcttgcaggttgccagggtgccaggccagggagggggcctttctgagattctcctcattctgacacaggagaggagggcactgacccagtcccaaggtcccgggggaatcagccgaccacagcccaggactgtcccacctgggcagagagcccattctgggtgcccagcccgggcaggcccaggcacccccagcagtgccccgggcagcacctgccagccaggtagtgcagggtgaggttgggcagggcagggcgtggtaggtcagctgagcaaacagctcggagggagagctggggagggctgggaactaggtcgatagaaacacagggactgtgttagggaggggatgccttgccagtcacgcccagccctgactcctgccctctgagggggcttcccccacccctgctgacagccccaggaccggcccctgccaggaggctgacctgccaggagtgaccgccccagacttgagcccttgggaggcaggttctgagtccccttttcctgctcagacccccagggaaacgcaggctgggccagaggcagctgcacagacccctgcagtggggtgctcggtggagagcgctggaggtgggagggaggatgtgtgaggcagcgggagagaatccaggcttcccccacaacacccaccatgagcggtgcagagtaggggtgggcggcacgggagccttcccaccccgcagaaccaggccctgggcagagctggcctacagacgataccggacaagtcctcctccgtcttggtgacagagggagctgggactccctccacccacccactgccacttcagaagcagccacagggagactgggaggggcaggggtgctggggatgagcgtggggctcagccctccctcttcccaccctggagggctgcctccttccagcccacctggaagggtggtgtcagtcccagagcccctgcactccccgccccacctcctgcagctggaacccgcgtgggagccgcacccagcgtcccagggacaaacacagaggccttgggtggtggcggtaccaaggtctgaggcctggcagctcaggggcacccccgtccctgagagaggtcaagaaggggaggcaccaccccccaccacgggacctcgctgacgatgcccatagagagaaaccaggccagtgctgggaggggaaagaccccaggcctcatgagaagtcactgcctgcttttcccctcggccaggaaggaagccccaggcccttccctcccgtctcgggcatactgaccccaggcaccaagcgagaccaggagcccacccctttcctttcccagatggcacaccagtgactctgaatat cggagcgcacccctgctccctgggaggcaggatatcgtgccgctgctccctggggcgcacgataccctccccaggaaggcgccggtcagggcggacgggccagggtgctcaccggtaccaggcgaggccgcgctcgtagcacctgtcgaagaagtggggctcagagcccagcgcgcggacgtcggggtgcagccgcagaaactccagcagggcgcgcgtgccgcccttcttcacgccaacgatgagcgcttgcgggaagcgccggcggccgggaccgctggccaaaggcaggccgggtgctcccgggcggtggacggagctggacggctcggagggcgcgggggccggcgcgggggcgcgggcggccggcgggcagcggccggggagggcgcagaggcagtaggcgccgagcaccagggccacgagcagcatcggcgcgcgggacgcccgcagagcggccccttgcccggcccctgcgccctggccgcccccggccccgccgcccaggccgccgctacctgccatggggtcgcgccgctccaggcccgggagcgggggcagcaggcgggcgcgcatctcggcccgcgcgccgctcagtccgtgggtgcccggcttgtgctctgcgcccggcggtcccgcagcctgggagcgggcgcggggcgggaccgggggcggggtctggacgccctcccccctccccctcccccgcccactccgcctccgaggccactgcctgggctggacccgccggcagccgccaccacccgggcgcgactcgagctgccgggaccaccaggacgctcctgctccgagatcccaggccctggctcgcttgactccggcatcttcacctctgcgcggggaggatgcggcggcggtggccgttcgggacgcagggcagggacagggcggcgcgcgggcctcgggaccctctgtttgaagaccgatccccttccccccccaccccactccgggacgtgcgcggcaggtgcataggccaagccttggcctgcaggagcgggagcctcatcgccaggccaaggggacccaggaaaagcgtcgatccgggcactcggcctgccaagggagaaagaggccgggacagcaccctagtgtgcagagagggatcccagaacgtgtggggggagtctgcggccgggaatggcgtgcg cctcctcttcctgcctgctggagggaccagcaccaaaacaggaaagttcaccctgccaggccttctctccaaagagtcagagggagctccgtagggggatggggttcccggaccccctgccgtggaaggggagtgggaacacagacaggcggcaagggctttcgaggccccctcttgcacaaaccagctcagagatcggagatctttgggatcaattactttccctccccaggcatccgaagcctatcctagcccaggtgtggatgagggtgggagagacgggggaggagggagaggagcaggactggacccccgtgtgacaaacatctgacaagttgctctgaggactgcccccctccttgtggagcccacctcatctggtgtgcatttccctgcggctttcatccagccctgggcgaccctccctcctccatctcagcctccctcctcctgccccacacctcaggcctgggactcgcagatgccaaaagggcctggcagatgccaaagccagaaagtgcagggggactgcatcccccacaggagaccgggttcttccccactacatactcagaccccactccctgcacccactgctcttgcaaaccaggaactaaggggttcccctacccaccccgctccttgcctcctcttgcttttcttttgttttgtttgtttttgagacagagctgcactccagctgactcttgtcgcccaggctggagtgcagtggcacaatctcagctcactacaacctctgcctcccgggttcaagcgattctcctgcctcagcctcccaagtagctgggaatacaggcacccatcaccacgcctggctaatttttgtatttttagtagagatggggtttcaccatgttagtcaggctggtctcaaactcctgacctcaggtaatctgcccacctcagcctcccaaagggctgggattacaggcgtgagccactgtgccccaccctcctcttgcttttctaaaagatgatggtcaaagtacagcccccatttgcccccagacagggcacccttcccagatcgagaccttggggagtctgcgtgacccccacacctggcagacacaggtgcttcactagtgggggaacggctgagcatgtgctgagctcgggggcactagtgggctacagtccccaagtgggaggcccctcaagagcctggatgagctgactgacggtggagaggagggaaggagggcctatggccaaagtcaatccaggacccaactgccgaggccacaggaaggccgggtcaccgcctggaactaggtcggtcacagcccagtgggagccgtggcccggagactcaactgggggccctggttactctgctcgcctccccgcgtcggcacccagaacagagcttgcaggcactgggggcccagtccagggtctcaagagcagacaatgctgccttgcagttggggaaactgagacagggtgagaactttcagaggctcattgcaggctcctagcaggctgaaaggacggaggcacaggcacctaggagcacaccagccccacgtggccacggcccctcggagagcatgaggacacttgcaatgcggaagctcagcaggcccagctctactggctctgcaccgcccagtgaggggtcagcacagttggtccaagggacaataccagattaatgaggcagaagccacgggactgaccccttggaattctccacacccacactgtgcatccttaacccaaagcttctagcttggtagcccctcctaccctcctccctgcagcagggattagggatgcattctgacccctgcctgccgtcaggggagtgaggtctctccctggagcctgagctgaggatgcccaattcagccaggtgagccccgggatggactccatgtcccctagccaccacctgacttccccagcaccccacactggcaccagcccttcagatctcagaagcgagccaccctattctcacggagccccttcctgcctgccctccaaacccaagagtagttttagtacaaaaggcaaagttaacaaataggggtaggcgtcagggaaggaagaggatcagaggatcgggaacggagaaactggagcacctggagaagcgtctgggtcctgccacccccactgactccccaactggccttgggcagggtcctctctgcaggcgctgggtccaagcttggggatgagcagccaccagcgcgggctgcttcagctgaggctgccgcacccccacgtccatcctgggtagaggcaggacagccacagagccccatgcacggggctggactcaccctgggcactcacctaaaggcagtctcctcctttccaaagcccagactttctccggactcccaggaccaccaacaagggttcctgtgcgcagactcgggggtcttggggaggaaggacgctttctaggtggctgcctggaacctggaggcccctttctacagtacctggccagcggtcggtcacacctgagtgcccagagtgagcgggcggcagaggcatttctgacgctgccaggtaatcccacgggctggaaacgacctctgggctgggaagccaccgcctcccccagtcctgctgggtccctcagcagagagaacggaaccggggctttccccacagttttcaaagtttcagggaatcctagccaagtatcattccttcttccggagccgggaccccaggtcaagcctggggcccccacagggcggtcccaaccccactgcccggagcgcacccctgctccctgggaggcaggatatcgtgccgctgctccctggggcgcacgataccctccccaggaaggcgccggtcagggcggacgggccagggtgctcaccggtaccaggcgaggccgcgctcgtagcacctgtcgaagaagtggggctcagagcccagcgcgcggacgtcggggtgcagccgcagaaactccagcagggcgcgcgtgccgcccttcttcacgccaacgatgagcgcttgcgggaagcgccggcggccgggaccgctggcgtttccctcccaggggcccagtggtgaactgaattcaggcctgagacatactctgtctactaagtcaccccatctgcccagccttggtccacctggcactgcccagagacatcagtgatgcatttcggaagctggcaaagtggaccccactggagtacaaaggactcagggacccctgtgctggggaagagaaggagcccaggacctcccccaggggctgcctctgaggggcgtgagattcaggggcctctcgggtgggacctgcgggggccgctagacactgcgggaacttcacatccccaacgcccagcagcagcctgcagggaaggcaggggaggcgagccgggctcagagagggcgagcaacttgccccatccgaaggcaaaggtggtatgagacccgggtcctctctccacctctgccccagccttcctggccacagggctggcgccaggcaggcacggcacaggctcccggcagaggccacggtctcagccatccccacggtctcaggagtccccacggtctcagccgtccccacggtctgagtccccacggtctcagctgttcccacggtctcaggagtccccacaggttcagcagtccccacggtctcagccatccccacggtctcagccgtccccacagtctcagccatccccacggtctcagcagtccctactcaggacttgaaattccagcactggttccgtgatggctcctccagccccctgcccagcccagcatggtcatttccatctcctggcctttccgctgccgtctctctgctggatgctttatccttagtccccgctgagggcagaaggactttccaggaggaattgaccagaacgcagaacagcaggatgtggaatggactggggacagggagagagagatgcagggaccaggagtcggctcggagggttctcctggaagctgacccctccctccatcaggcactcggctgacggtggctacacacctcggggcgcccaggatggcagcactggggctgttcattcaccagtggatccccagcacctaacagagcctggcacgcagtggacattccattaatgtcgctcagtggaagggtatacgtgggaggagaggtcgggaaggctttctggaggtgacggccaggtgaagacgaggagaacagcattccaggccaaggaaccgtgtgggtgaaggctcagcagcagagagcccgggcagtagaggatggggtggagcttaaggccctgcgggaacaggggcggggcttagagtctggcctgaggctggtccagccccgcctcctcctcaggctcccaccaactctgagccaccagaccctcctttgtaaaatgaagacctcagtcatgactcgcatgagtctctgaagagtaacagctttattgtgatgtaattcacacaccactcaatccagccatttgtcgcatgcaaatcaatggttttcagtatattcatagtcgtgcaatcacaatcaattttagaacatttctatcaccccaaaaagaaatcctgtgtccattagcaatgacgccctcttctccccttcccacagcccctggcaaccacgaatctactttctgtctctatgggtttgcctattctggacatttcacaaaaagagaatcattgcttgaagccaggagttcaagaccaacctgggcaacaaagcgagaaccccgtctgtacaaaatattttaaatttagccaggcacagtggcgcacaccagtagtcccagcactttggaagtctgaggcaggaggttcacttgaggcggggaattcaaaaccagcctgggcaacatagggagtaccagtctctacaaaaaatttcaaaatttgccaagcgtgatggtatgcacctatagtcctagcttactcaggaggctgaggtgggaggatcgcttgagcccaggagtacgaggctgcagtgagccatgatcataccactgcattccagcctgggcgacagagtgagagcccatctctaaaacagaaagaaagaaagaaagaaatatggccagtcacagtggctcatgcctgtaatcccagcattttgggaggccaaggcaggtggatcacttgaggtcaggagttcgagaccagcctggccaacatggtgaaaccctgtctctaccaaaaatacataaattagccaggtgtgggccaggcgccatggcttacacttgtaatcccagcactttgggaggccgaggtgggcagatcacctgaggttgagagttcgagaccagcctgaccaacatgaagaaaccctgtctctactaaaaatacaaaaaattagctgggtgtggtggtgcatgcctgtaatctcagctacttgggaggctgaggaaggagaatggcttgaacccgggaggcagaggttgtggtgagccgagatcgcgcgattgcactccagcctgggcaacaacagcaaaactccatctcaaataataataataataaattagccaggtgtggtggtgcacgcctgtagtcccagctactcgggaggctgaggcacaagaaacccttgaacccgggaggcagaggttgcagtgaagctgaaattgcaccattccactccagcctgggagacagagtgagacaccatctctaaaatgaaaaaaaaaaaagagaatcatacaatgttcgtccttttgtgtctgggtctcttactcagcatgttctccaggttcatcaacactgtggcatgtgccagtacctccttcctcttcctgactgagtaatactccatcgtatggatggaccaccttttgttgattccctcattcgttgatggacatctaggttgtttccactgcggggttcttagtaacggtattacagggaaccatagattaccaggtatt How do you locate the CpG island in a DNA sequence?\n

agaattgcttgaaccgggaggcggaggttgcaatgagctgagatcacaccactgcactccagcatggtgacagagcaagactccatctcaaatcgagtaaaa aaaaaaaaatagctgggtgcggtggctcacgcctgtaatcccagcactttgggaggctgaggcgggtagatcacgaggtcaggagatcgtagccatcctggctaacacggtgaaaccccgtctctactaaaaatacaaaaagaaattagctgggcgtggtggtgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggcgtgaacccgggaggtggagcttgcagtgagtcgagatcacgccactgcactccagcctgggcgacagagcgagactcgatctcaaaaaaaaaaaaaaaaaaaaagtgcgacacgaggcacacagtcagtgcccagtggagttcgctgatatggttaccacatccctggggacagcgcctccaccctccaacctcgaggtttgtggaaaaatctgggtccaagctttatttcttaaatattcctctctgcccagcatgtgcacgcagcccgctctggccaggcgagcgggtgtcaatcaaggtgctgagcatccccagggtgccgctcagccccagccgaagtcctggcccgtcatctggtagaacctgcggttgaagggccggtagaactcctgcaggcgccggaccagggcctggggcacgcgtgggtgtggccggcccttggacttgcccaggcagcggggacggctgccgccctgggccttcttgaggcaggggaagcccttggtggcgttgaagtagaagtgcttgtccgtgacgacccgtttcaggcccaggaagtcctgcacgcggccgacctctccggccgggtcgctgaccagacgctccccgctgacgaacaggaagtgggacagggggaagtagcgcagccagtggtccaggtgctgggcgtacaggccgatgcggacggcgctccaggctgtgtccacggggcccaggccgtggcggaaggccagggcgcggaagctgggcaggcccggggtcttggagagcgtctgggcgtagtcggagatggcccgggtcacggggttccgcaccaccacgatcagcttcgtgtccggggacatggcgtggatgcggcggggggcctctcgcgtcacgaagtagctgggggtcttctccatggtgatctgcccatccagggttcggggcatcagactcctgcgggacgggtgcaaggagagggggcctgagcctccccagccctagaccggcccccaggggcccgggaccaaggcccccttatgcccgggaagcccaggcctccagggcgagcaagtcttcctccctgctcgggcccacccctgctagcgtgcgcggctgggcagcctggaacatggactgtgagggtgcccagcccggcacctgcctgcagcccggcctgttccgccggcctgccccgcctgctgctgcactgaggattagggtgacggtcgctggtcgggaggcccaaatgctcctcaccacccacatatcttccctgtgcaatccctgccgtcctcgcttccagagccagctccctcccaccggacccacactttcctggaactaggctgcccccagctcctttctcatcccagaccaagtaccccgaggcccgcccgcctagatcacttgaggtcacccgttcactcagtggctgacagcatcccctaaatcagcccttcaccaattattgacagtgtgtcctcaaccaaaagtagtcctccctgctccctccctcccctgatgtaattacatctcttcccatctttatttattttttg

C+G Content: 0.492 Observed/Expected: 0.548\n

a gaattgcttgaaccgggaggcggaggttgcaatgagctgagatcacaccactgcactccagcatggtgacagagcaagactccatctcaaatcgagtaaaa aaaaaaaaatagctgggtgcggtggctcacgcctgtaatcccagcactttgggaggctgaggcgggtagatcacgaggtcaggagatcgtagccatcctggctaacacggtgaaaccccgtctctactaaaaatacaaaaagaaattagctgggcgtggtggtgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggcgtgaacccgggaggtggagcttgcagtgagtcgagatcacgccactgcactccagcctgggcgacagagcgagactcgatctcaaaaaaaaaaaaaaaaaaaaagtgcgacacgaggcacacagtcagtgcccagtggagttcgctgatatggttaccacatccctggggacagcgcctccaccctccaacctcgaggtttgtggaaaaatctgggtccaagctttatttcttaaatattcctctctgcccagcatgtgcacgcagcccgctctggccaggcgagcgggtgtcaatcaaggtgctgagcatccccagggtgccgctcagccccagccgaagtcctggcccgtcatctggtagaacctgcggttgaagggccggtagaactcctgcaggcgccggaccagggcctggggcacgcgtgggtgtggccggcccttggacttgcccaggcagcggggacggctgccgccctgggccttcttgaggcaggggaagcccttggtggcgttgaagtagaagtgcttgtccgtgacgacccgtttcaggcccaggaagtcctgcacgcggccgacctctccggccgggtcgctgaccagacgctccccgctgacgaacaggaagtgggacagggggaagtagcgcagccagtggtccaggtgctgggcgtacaggccgatgcggacggcgctccaggctgtgtccacggggcccaggccgtggcggaaggccagggcgcggaagctgggcaggcccggggtcttggagagcgtctgggcgtagtcggagatggcccgggtcacggggttccgcaccaccacgatcagcttcgtgtccggggacatggcgtggatgcggcggggggcctctcgcgtcacgaagtagctgggggtcttctccatggtgatctgcccatccagggttcggggcatcagactcctgcgggacgggtgcaaggagagggggcctgagcctccccagccctagaccggcccccaggggcccgggaccaaggcccccttatgcccgggaagcccaggcctccagggcgagcaagtcttcctccctgctcgggcccacccctgctagcgtgcgcggctgggcagcctggaacatggactgtgagggtgcccagcccggcacctgcctgcagcccggcctgttccgccggcctgccccgcctgctgctgcactgaggattagggtgacggtcgctggtcgggaggcccaaatgctcctcaccacccacatatcttccctgtgcaatccctgccgtcctcgcttccagagccagctccctcccaccggacccacactttcctggaactaggctgcccccagctcctttctcatcccagaccaagtaccccgaggcccgcccgcctagatcacttgaggtcacccgttcactcagtggctgacagcatcccctaaatcagcccttcaccaattattgacagtgtgtcctcaaccaaaagtagtcctccctgctccctccctcccctgatgtaattacatctcttcccatctttatttattttttg

C+G Content: 0.501 Observed/Expected: 0.568\n

ag aattgcttgaaccgggaggcggaggttgcaatgagctgagatcacaccactgcactccagcatggtgacagagcaagactccatctcaaatcgagtaaaaa aaaaaaaatagctgggtgcggtggctcacgcctgtaatcccagcactttgggaggctgaggcgggtagatcacgaggtcaggagatcgtagccatcctggctaacacggtgaaaccccgtctctactaaaaatacaaaaagaaattagctgggcgtggtggtgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggcgtgaacccgggaggtggagcttgcagtgagtcgagatcacgccactgcactccagcctgggcgacagagcgagactcgatctcaaaaaaaaaaaaaaaaaaaaagtgcgacacgaggcacacagtcagtgcccagtggagttcgctgatatggttaccacatccctggggacagcgcctccaccctccaacctcgaggtttgtggaaaaatctgggtccaagctttatttcttaaatattcctctctgcccagcatgtgcacgcagcccgctctggccaggcgagcgggtgtcaatcaaggtgctgagcatccccagggtgccgctcagccccagccgaagtcctggcccgtcatctggtagaacctgcggttgaagggccggtagaactcctgcaggcgccggaccagggcctggggcacgcgtgggtgtggccggcccttggacttgcccaggcagcggggacggctgccgccctgggccttcttgaggcaggggaagcccttggtggcgttgaagtagaagtgcttgtccgtgacgacccgtttcaggcccaggaagtcctgcacgcggccgacctctccggccgggtcgctgaccagacgctccccgctgacgaacaggaagtgggacagggggaagtagcgcagccagtggtccaggtgctgggcgtacaggccgatgcggacggcgctccaggctgtgtccacggggcccaggccgtggcggaaggccagggcgcggaagctgggcaggcccggggtcttggagagcgtctgggcgtagtcggagatggcccgggtcacggggttccgcaccaccacgatcagcttcgtgtccggggacatggcgtggatgcggcggggggcctctcgcgtcacgaagtagctgggggtcttctccatggtgatctgcccatccagggttcggggcatcagactcctgcgggacgggtgcaaggagagggggcctgagcctccccagccctagaccggcccccaggggcccgggaccaaggcccccttatgcccgggaagcccaggcctccagggcgagcaagtcttcctccctgctcgggcccacccctgctagcgtgcgcggctgggcagcctggaacatggactgtgagggtgcccagcccggcacctgcctgcagcccggcctgttccgccggcctgccccgcctgctgctgcactgaggattagggtgacggtcgctggtcgggaggcccaaatgctcctcaccacccacatatcttccctgtgcaatccctgccgtcctcgcttccagagccagctccctcccaccggacccacactttcctggaactaggctgcccccagctcctttctcatcccagaccaagtaccccgaggcccgcccgcctagatcacttgaggtcacccgttcactcagtggctgacagcatcccctaaatcagcccttcaccaattattgacagtgtgtcctcaaccaaaagtagtcctccctgctccctccctcccctgatgtaattacatctcttcccatctttatttattttttg

C+G Content: 0.500 Observed/Expected: 0.560\n

agaattgcttgaaccgggaggcggaggttg caatgagctgagatcacaccactgcactccagcatggtgacagagcaagactccatctcaaatcgagtaaaaaaaaaaaaatagctgggtgcggtggctcacgcctgtaatcccagcactttgggaggctgaggcgggtagatcacgaggtcaggagatcgtagccatcctggctaacacggtgaaaccccgtctctactaaaaatacaaaaagaaattagctgggcgtggtggtgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggc gtgaacccgggaggtggagcttgcagtgagtcgagatcacgccactgcactccagcctgggcgacagagcgagactcgatctcaaaaaaaaaaaa aaaaaaaaagtgcgacacgaggcacacagtcagtgcccagtggagttcgctgatatggttaccacatccctggggacagcgcctccaccctccaacctcgaggtttgtggaaaaatctgggtccaagctttatttcttaaatattcctctctgcccagcatgtgcacgcagcccgctctggccaggcgagcgggtgtcaatcaaggtgctgagcatccccagggtgccgctcagccccagccgaagtcctggcccgtcatctggtagaacctgcggttgaagggccggtagaactcctgcaggcgccggaccagggcctggggcacgcgtgggtgtggccggcccttggacttgcccaggcagcggggacggctgccgccctgggccttcttgaggcaggggaagcccttggtggcgttgaagtagaagtgcttgtccgtgacgacccgtttcaggcccaggaagtcctgcacgcggccgacctctccggccgggtcgctgaccagacgctccccgctgacgaacaggaagtgggacagggggaagtagcgcagccagtggtccaggtgctgggcgtacaggccgatgcggacggcgctccaggctgtgtccacggggcccaggccgtggcggaaggccagggcgcggaagctgggcaggcccggggtcttggagagcgtctgggcgtagtcggagatggcccgggtcacggggttccgcaccaccacgatcagcttcgtgtccggggacatggcgtggatgcggcggggggcctctcgcgtcacgaagtagctgggggtcttctccatggtgatctgcccatccagggttcggggcatcagactcctgcgggacgggtgcaaggagagggggcctgagcctccccagccctagaccggcccccaggggcccgggaccaaggcccccttatgcccgggaagcccaggcctccagggcgagcaagtcttcctccctgctcgggcccacccctgctagcgtgcgcggctgggcagcctggaacatggactgtgagggtgcccagcccggcacctgcctgcagcccggcctgttccgccggcctgccccgcctgctgctgcactgaggattagggtgacggtcgctggtcgggaggcccaaatgctcctcaccacccacatatcttccctgtgcaatccctgccgtcctcgcttccagagccagctccctcccaccggacccacactttcctggaactaggctgcccccagctcctttctcatcccagaccaagtaccccgaggcccgcccgcctagatcacttgaggtcacccgttcactcagtggctgacagcatcccctaaatcagcccttcaccaattattgacagtgtgtcctcaaccaaaagtagtcctccctgctccctccctcccctgatgtaattacatctcttcccatctttatttattttttg

C+G Content: 0.712 Observed/Expected: 0.604 200 steps later…\n

agaattgcttgaaccgggaggcggaggttg caatgagctgagatcacaccactgcactccagcatggtgacagagcaagactccatctcaaatcgagtaaaaaaaaaaaaatagctgggtgcggtggctcacgcctgtaatcccagcactttgggaggctgaggcgggtagatcacgaggtcaggagatcgtagccatcctggctaacacggtgaaaccccgtctctactaaaaatacaaaaagaaattagctgggcgtggtggtgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggcgtgaacccgggaggtggagcttgcagtgagtcgagatcacgccactgcactccagcctgggcgacagagcgagactcgatctcaaa aaaaaaaaaaaaaaaaaagtgcgac acgaggcacacagtcagtgcccagtggagttcgctgatatggttaccacatccctggggacagcgcctccaccctccaacctcgaggtttgtggaaaaatctgggtccaagctttatttcttaaatattcctctctgcccagcatgtgcacgcagcccgctctggccaggcgagcgggtgtcaatcaaggtgctgagcatccccagggtgccgctcagccccagccgaagtcctggcccgtcatctggtagaacctgcggttgaagggccggtagaactcctgcaggcgccggaccagggcctggggcacgcgtgggtgtggccggcccttggacttgcccaggcagcggggacggctgccgccctgggccttcttgaggcaggggaagcccttggtggcgttgaagtagaagtgcttgtccgtgacgacccgtttcaggcccaggaagtcctgcacgcggccgacctctccggccgggtcgctgaccagacgctccccgctgacgaacaggaagtgggacagggggaagtagcgcagccagtggtccaggtgctgggcgtacaggccgatgcggacggcgctccaggctgtgtccacggggcccaggccgtggcggaaggccagggcgcggaagctgggcaggcccggggtcttggagagcgtctgggcgtagtcggagatggcccgggtcacggggttccgcaccaccacgatcagcttcgtgtccggggacatggcgtggatgcggcggggggcct ctcgc gtcacgaagtagctgggggtcttctccatggtgatctgcccatccagggttcggggcatcagactcctgcgggacgggtgcaaggagagggggc ctgagcctccccagccctagaccggcccccaggggcccgggaccaaggcccccttatgcccgggaagcccaggcctccagggcgagcaagtcttcctccctgctcgggcccacccctgctagcgtgcgcggctgggcagcctggaacatggactgtgagggtgcccagcccggcacctgcctgcagcccggcctgttccgccggcctgccccgcctgctgctgcactgaggattagggtgacggtcgctggtcgggaggcccaaatgctcctcaccacccacatatcttccctgtgcaatccctgccgtcctcgcttccagagccagctccctcccaccggacccacactttcctggaactaggctgcccccagctcctttctcatcccagaccaagtaccccgaggcccgcccgcctagatcacttgaggtcacccgttcactcagtggctgacagcatcccctaaatcagcccttcaccaattattgacagtgtgtcctcaaccaaaagtagtcctccctgctccctccctcccctgatgtaattacatctcttcccatctttatttattttttg

C+G Content: 0.598 Observed/Expected: 0.421 600 steps later…\nJust a couple formulas…

G+C content =

(# of C’s) + (# of G’s )

length of window

Obs/Exp ratio =

Observed # of CpGs # of CpG’s in window

Expected # of CpGs (# of C’s)x(# of G’s)

length

= From window\nTraditional Methods

Gardiner-Garden and Frommer (1987)

Window size 100 bp and Shift size 1bp

Criteria

At least 200 base pairs

G + C content greater than 50%

Expected portion of the Obs/Exp ratio calculated over the window

Obs/Exp ratio greater than 0.6

Takai and Jones (2002)

Window size 200 bp and Shift size 1bp

Criteria

At least 500 base pairs

At least 7 CpG dinucleotides in 200 base pair sequence

G + C content greater than 55%

Obs/Exp ratio calculated in same fashion as above method

Obs/Exp ratio greater than 0.65

\nThe Traditional Method C+G content Obs/Exp ratio C+G content /Obs-Exp ratio Base Position Sequence AL031723\n

Modifying the traditional methods

Window size 200 bp and Shift size 1 bp

Expected portion of the Obs/Exp ratio is based on whole sequence

And….

Our Method

Observed # of CpGs # of CpG’s in window

Expected # of CpGs (# of C’s)x(# of G’s)

length

= From entire sequence\n

Cutoffs greater than 97th percentile of observed sequence

Obs/Exp Ratio G+C Content Mean: 0.0018 Standard Deviation: 0.0014 97th percentile: 0.0058 Mean: 0.5815 Standard Deviation: 0.0818 97th percentile: 0.7350 G+C Content Obs/Exp Ratio Number of Observations Number of Observations Sequence AL031723\nKullback-Leibler Divergence

p ln (p/0.03) + (1-p) ln ((1-p)/(1-0.03))

p KL Divergence\n

agaattgcttgaaccgggaggcggaggttgcaatgagctgagatcacaccactgcactccagcatggtgacagagcaagactccatctcaaatcgagtaaaaaaaaaaaaatagctgggtgcggtggctcacgcctgtaatcccagcactttgggaggctgaggcgggtagatcacgaggtcaggagatcgtagccatcctggctaacacggtga aaccccgtctctactaaaaatacaaaaagaaattagctgggcgtggtggtgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggcgtgaacccgggaggtggagcttgcagtgagtcgagatcacgccactgcactccagcctgggcgacagagcgagactcgatctcaaaaaaaaaaaaaaaaaaaaagtgcgacacgaggcacacagtcagtgcccagtggagttcgctgatatggttaccacatccctggggacagcgcctccaccctccaacctcgaggtttgtggaaaaatctgggtccaagctttatttcttaaatattcctctctgcccagcatgtgcacgcagcccgctctggccaggcgagcgggtgtcaatcaaggtgctgagcatccccagggtgccgctcagccccagccgaagtcctggcccgtcatctggtagaacctgcggttgaagggccggtagaactcctgcaggcgccggaccagggcctggggcacgcgtgggtgtggccggcccttggacttgcccaggcagcggggacggctgccgccctgggccttcttgaggcaggggaagcccttggtggcgttgaagtagaagtgcttgtccgtgacgacccgtttcaggcccaggaagtcctgcacgcggccgacctctccggccgggtcgctgaccagacgctccccgctgacgaacaggaagtgggacagggggaagtagcgcagccagtggtccaggtgctgggcgtacaggccgatgcggacggcgctccaggctgtgtccacggggcccaggccgtggcggaaggccagggcgcggaagctgggcaggcccggggtcttggagagcgtctgggcgtagtcggagatggcccgggtcacggggttccgcaccaccacgatcagcttcgtgtccggggacatggcgtggatgcggcggggggcctctcgcgtcacgaagtagctgggggtcttctccatggtgatctgcccatccagggttcggggcatcagactcctgcgggacgggtgcaaggagagggggcctgagcctccccagccctagaccggcccccaggggcccgggaccaaggcccccttatgcccgggaagcccaggcctccagggcgagcaagtcttcctccctgctcgggcccacccctgctagcgtgcgcggctgggcagcctggaacatggactgtgagggtgcccagcccggcacctgcctgcagcccggcctgttccgccggcctgccccgcctgctgctgcactgaggattagggtgacggtcgctggtcgggaggcccaaatgctcctcaccacccacatatcttccctgtgcaatccctgccgtcctcgcttccagagccagctccctcccaccggacccacactttcctggaactaggctgcccccagctcctttctcatcccagaccaagtaccccgaggcccgcccgcctagatcacttgaggtcacccgttcactcagtggctgacagcatcccctaaatcagcccttcaccaattattgacagtgtgtcctcaaccaaaagtagtcctccctgctccctccctcccctgatgtaattacatctcttcccatctttatttattttttg

Kullback-Leibler: 0.508 Our Obs/Exp: 0.0029 C+G: 0.492\n

a gaattgcttgaaccgggaggcggaggttgcaatgagctgagatcacaccactgcactccagcatggtgacagagcaagactccatctcaaatcgagtaaaaaaaaaaaaatagctgggtgcggtggctcacgcctgtaatcccagcactttgggaggctgaggcgggtagatcacgaggtcaggagatcgtagccatcctggctaacacggtgaa accccgtctctactaaaaatacaaaaagaaattagctgggcgtggtggtgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggcgtgaacccgggaggtggagcttgcagtgagtcgagatcacgccactgcactccagcctgggcgacagagcgagactcgatctcaaaaaaaaaaaaaaaaaaaaagtgcgacacgaggcacacagtcagtgcccagtggagttcgctgatatggttaccacatccctggggacagcgcctccaccctccaacctcgaggtttgtggaaaaatctgggtccaagctttatttcttaaatattcctctctgcccagcatgtgcacgcagcccgctctggccaggcgagcgggtgtcaatcaaggtgctgagcatccccagggtgccgctcagccccagccgaagtcctggcccgtcatctggtagaacctgcggttgaagggccggtagaactcctgcaggcgccggaccagggcctggggcacgcgtgggtgtggccggcccttggacttgcccaggcagcggggacggctgccgccctgggccttcttgaggcaggggaagcccttggtggcgttgaagtagaagtgcttgtccgtgacgacccgtttcaggcccaggaagtcctgcacgcggccgacctctccggccgggtcgctgaccagacgctccccgctgacgaacaggaagtgggacagggggaagtagcgcagccagtggtccaggtgctgggcgtacaggccgatgcggacggcgctccaggctgtgtccacggggcccaggccgtggcggaaggccagggcgcggaagctgggcaggcccggggtcttggagagcgtctgggcgtagtcggagatggcccgggtcacggggttccgcaccaccacgatcagcttcgtgtccggggacatggcgtggatgcggcggggggcctctcgcgtcacgaagtagctgggggtcttctccatggtgatctgcccatccagggttcggggcatcagactcctgcgggacgggtgcaaggagagggggcctgagcctccccagccctagaccggcccccaggggcccgggaccaaggcccccttatgcccgggaagcccaggcctccagggcgagcaagtcttcctccctgctcgggcccacccctgctagcgtgcgcggctgggcagcctggaacatggactgtgagggtgcccagcccggcacctgcctgcagcccggcctgttccgccggcctgccccgcctgctgctgcactgaggattagggtgacggtcgctggtcgggaggcccaaatgctcctcaccacccacatatcttccctgtgcaatccctgccgtcctcgcttccagagccagctccctcccaccggacccacactttcctggaactaggctgcccccagctcctttctcatcccagaccaagtaccccgaggcccgcccgcctagatcacttgaggtcacccgttcactcagtggctgacagcatcccctaaatcagcccttcaccaattattgacagtgtgtcctcaaccaaaagtagtcctccctgctccctccctcccctgatgtaattacatctcttcccatctttatttattttttg

Kullback-Leibler: 0.509 Our Obs/Exp: 0.0030 C+G: 0.501\n

ag aattgcttgaaccgggaggcggaggttgcaatgagctgagatcacaccactgcactccagcatggtgacagagcaagactccatctcaaatcgagtaaaaaaaaaaaaatagctgggtgcggtggctcacgcctgtaatcccagcactttgggaggctgaggcgggtagatcacgaggtcaggagatcgtagccatcctggctaacacggtgaaa ccccgtctctactaaaaatacaaaaagaaattagctgggcgtggtggtgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggcgtgaacccgggaggtggagcttgcagtgagtcgagatcacgccactgcactccagcctgggcgacagagcgagactcgatctcaaaaaaaaaaaaaaaaaaaaagtgcgacacgaggcacacagtcagtgcccagtggagttcgctgatatggttaccacatccctggggacagcgcctccaccctccaacctcgaggtttgtggaaaaatctgggtccaagctttatttcttaaatattcctctctgcccagcatgtgcacgcagcccgctctggccaggcgagcgggtgtcaatcaaggtgctgagcatccccagggtgccgctcagccccagccgaagtcctggcccgtcatctggtagaacctgcggttgaagggccggtagaactcctgcaggcgccggaccagggcctggggcacgcgtgggtgtggccggcccttggacttgcccaggcagcggggacggctgccgccctgggccttcttgaggcaggggaagcccttggtggcgttgaagtagaagtgcttgtccgtgacgacccgtttcaggcccaggaagtcctgcacgcggccgacctctccggccgggtcgctgaccagacgctccccgctgacgaacaggaagtgggacagggggaagtagcgcagccagtggtccaggtgctgggcgtacaggccgatgcggacggcgctccaggctgtgtccacggggcccaggccgtggcggaaggccagggcgcggaagctgggcaggcccggggtcttggagagcgtctgggcgtagtcggagatggcccgggtcacggggttccgcaccaccacgatcagcttcgtgtccggggacatggcgtggatgcggcggggggcctctcgcgtcacgaagtagctgggggtcttctccatggtgatctgcccatccagggttcggggcatcagactcctgcgggacgggtgcaaggagagggggcctgagcctccccagccctagaccggcccccaggggcccgggaccaaggcccccttatgcccgggaagcccaggcctccagggcgagcaagtcttcctccctgctcgggcccacccctgctagcgtgcgcggctgggcagcctggaacatggactgtgagggtgcccagcccggcacctgcctgcagcccggcctgttccgccggcctgccccgcctgctgctgcactgaggattagggtgacggtcgctggtcgggaggcccaaatgctcctcaccacccacatatcttccctgtgcaatccctgccgtcctcgcttccagagccagctccctcccaccggacccacactttcctggaactaggctgcccccagctcctttctcatcccagaccaagtaccccgaggcccgcccgcctagatcacttgaggtcacccgttcactcagtggctgacagcatcccctaaatcagcccttcaccaattattgacagtgtgtcctcaaccaaaagtagtcctccctgctccctccctcccctgatgtaattacatctcttcccatctttatttattttttg

Kullback-Leibler: 0.507 Our Obs/Exp: 0.0029 C+G: 0.500\n

agaattgcttgaaccgggaggcggaggttgcaatgagctgagatcacaccactgcactccagcatggtgacagagcaagactccatctcaaatcgagtaaaaaaaaaaaaatagctgggtgcggtggctcacgcctgtaatcccagcacttt gggaggctgaggcgggtagatcacgaggtcaggagatcgtagccatcctggctaacacggtgaaaccccgtctctactaaaaatacaaaaagaaattagctgggcgtggtggtgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggc gtgaacccgggaggtggagcttgcagtgagtcgagatcacgccactgcactccagcctgggcgacagagcgagactcgatctcaaaaaaaaaaaaaaaaaaaaagtgcgacacgaggcacacagtcagtgcccagtggagttcgctgatatggttaccacatccctggggacagcgcctccaccctccaacctcgaggtttgtggaaaaatctgggtccaagc tttatttcttaaatattcctctctgcccagcatgtgcacgcagcccgctctggccaggcgagcgggtgtcaatcaaggtgctgagcatccccagggtgccgctcagccccagccgaagtcctggcccgtcatctggtagaacctgcggttgaagggccggtagaactcctgcaggcgccggaccagggcctggggcacgcgtgggtgtggccggcccttggacttgcccaggcagcggggacggctgccgccctgggccttcttgaggcaggggaagcccttggtggcgttgaagtagaagtgcttgtccgtgacgacccgtttcaggcccaggaagtcctgcacgcggccgacctctccggccgggtcgctgaccagacgctccccgctgacgaacaggaagtgggacagggggaagtagcgcagccagtggtccaggtgctgggcgtacaggccgatgcggacggcgctccaggctgtgtccacggggcccaggccgtggcggaaggccagggcgcggaagctgggcaggcccggggtcttggagagcgtctgggcgtagtcggagatggcccgggtcacggggttccgcaccaccacgatcagcttcgtgtccggggacatggcgtggatgcggcggggggcctctcgcgtcacgaagtagctgggggtcttctccatggtgatctgcccatccagggttcggggcatcagactcctgcgggacgggtgcaaggagagggggcctgagcctccccagccctagaccggcccccaggggcccgggaccaaggcccccttatgcccgggaagcccaggcctccagggcgagcaagtcttcctccctgctcgggcccacccctgctagcgtgcgcggctgggcagcctggaacatggactgtgagggtgcccagcccggcacctgcctgcagcccggcctgttccgccggcctgccccgcctgctgctgcactgaggattagggtgacggtcgctggtcgggaggcccaaatgctcctcaccacccacatatcttccctgtgcaatccctgccgtcctcgcttccagagccagctccctcccaccggacccacactttcctggaactaggctgcccccagctcctttctcatcccagaccaagtaccccgaggcccgcccgcctagatcacttgaggtcacccgttcactcagtggctgacagcatcccctaaatcagcccttcaccaattattgacagtgtgtcctcaaccaaaagtagtcctccctgctccctccctcccctgatgtaattacatctcttcccatctttatttattttttg

200 steps later… Kullback-Leibler: 0.520 Our Obs/Exp: 0.0033 C+G: 0.712\n

agaattgcttgaaccgggaggcggaggttgcaatgagctgagatcacaccactgcactccagcatggtgacagagcaagactccatctcaaatcgagtaaaaaaaaaaaaatagctgggtgcggtggctcacgcctgtaatcccagcacttt gggaggctgaggcgggtagatcacgaggtcaggagatcgtagccatcctggctaacacggtgaaaccccgtctctactaaaaatacaaaaagaaattagctgggcgtggtggtgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggcgtgaacccgggaggtggagcttgcagtgagtcgagatcacgccactgcactccagcctgggcgacagagcgagactcgatctcaaaaaaaaaaaaaaaaaaaaagtgcgacacgaggcacacagtcagtgcccagtggagttcgctgatatggttaccacatccctggggacagcgcctccaccctccaacctcgaggtttgtggaaaaatctgggtccaagctttatttcttaaatattcctctctgcccagcatgtgcacgcagcccgctctggccaggcgagcgggtgtcaatcaaggtgctgagcatccccagggtgccgctcagccccagccgaagtcctggcccgtcatctggtagaacctgcggttgaagggccggtagaactcctgcaggcgccggaccagggcctggggcacgcgtgggtgtggccggcccttggacttgcccaggcagcggggacggctgccgccctgggccttcttgaggcaggggaagcccttggtggcgttgaagtagaagtgcttgtccgtgacgacccgtttcaggcccaggaagtcctgcacgcggccgacctctccggccgggtcgctgaccagacgctccccgctgacgaacaggaagtgggacagggggaagtagcgcagccagtggtccaggtgctgggcgtacaggccgatgcggacggcgctccaggctgtgtccacggggcccaggccgtggcggaaggccagggcgcggaagctgggcaggcccggggtcttggagagcgtctgggcgtagtcggagatggcccgggtcacggggttccgcaccaccacgatcagcttcgtgtccggggacatggcgtggatgcggcggggggcctct cgc gtcacgaagtagctgggggtcttctccatggtgatctgcccatccagggttcggggcatcagactcctgcgggacgggtgcaaggagagggggcctgagcctccccagccctagaccggcccccaggggcccgggaccaaggcccccttatgcccgggaagcccaggcctccagggcgagcaagtcttcctccctgctcgggcccacccctgctagcgtgcgcg gctgggcagcctggaacatggactgtgagggtgcccagcccggcacctgcctgcagcccggcctgttccgccggcctgccccgcctgctgctgcactgaggattagggtgacggtcgctggtcgggaggcccaaatgctcctcaccacccacatatcttccctgtgcaatccctgccgtcctcgcttccagagccagctccctcccaccggacccacactttcctggaactaggctgcccccagctcctttctcatcccagaccaagtaccccgaggcccgcccgcctagatcacttgaggtcacccgttcactcagtggctgacagcatcccctaaatcagcccttcaccaattattgacagtgtgtcctcaaccaaaagtagtcctccctgctccctccctcccctgatgtaattacatctcttcccatctttatttattttttg

600 steps later… Kullback-Leibler: 0.510 Our Obs/Exp: 0.0030 C+G: 0.598\nOur Method KL Divergence*12 / Obs-Exp ratio*160 / C+G Content Base Position Kullback-Leibler Divergence Observed/Expected Ratio C+G Content Sequence AL031723\nComparison of AL031723 Traditional Method Our Method\nComparison of AL031723 Traditional Method Possible CpG Islands 3878-4534 5849-6136 6541-6820 8479-8698 10745-11049 18435-19580 25131-26359 35182-35441 36245-36576 36827-37606 Actual CpG Islands 18928-19547 25201-26371 36997-37693\nComparison of AL031723 Our Method Possible CpG Islands 19227-19435 25197-26147 36982-37420 Actual CpG Islands 18928-19547 25201-26371 36997-37693\nCons

Traditional Method

Criteria not stringent enough

If the expected part of the Obs/Exp ratio is unusually high then a high CpG count may not bring ratio above the cutoff

Our Method

Criteria sometimes too stringent

\nFuture Plans

CpG Islands

Linkage Disequilibrium and SNPs

Statistical analysis of the linkage disequilibrium coefficient

Kullback-Leibler Divergence II

\nThank you!

Former researchers

Andrew Dittmore

Yasuhiro Goda

Nick Heppenstall

Michal Dvir

Deborah Lycan

John S. Rogers Program


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