url: =【非特許文献１】Nishimura EK et al. Nature. 416(6883):854-60, 2002\n【非特許文献２】Nishimura EK et al. Science. 307(5710):720-724. 2005\n本発明によれば、Ａｔａｘｉａ ｔｅｌａｎｇｉｅｃｔａｓｉａ ｍｕｔａｔｅｄ（Ａ\nまた、本発明によれば、ＡＴＭ ａｎｄ Ｒａｄ３−ｒｅｌａｔｅｄ（ＡＴＲ）または\n【図１】放射線照射前後におけるマウスの体色および組織学的変化を示す図である。（ａ）は放射線照射前のマウスの全身写真。（ｂ）は放射線照射後（５Ｇｙ ＩＲ（＋））の全身写真。放射線照射後にのみ白髪が誘導されている。（ｃ）〜（ｊ）は成長期Ｖ期における放射線照射後の毛包の組織学的な変化を示す。（ｃ）、（ｇ）はホールマウント像。（ｄ）、（ｈ）はＤｃｔ−ｌａｃＺトランスジェニックマウスのｌａｃＺ染色後の皮膚切片。コントロールマウスのバルジ領域において、メラニン色素を有していない色素幹細胞が確認できる（ｃ、ｄ中の矢印）。（ｅ）、（ｆ）、（ｉ）、（ｊ）はバルジ領域のｌａｃＺ陽性細胞を示す。この細胞は同時にＫｉｔを発現しており、明視野観察で放射線照射がない場合にはメラニンを持っていない（ｅ、ｆの矢印）。放射線を照射すると茶色から黒色の色素を含む（ｉ、ｊの矢頭）。５Ｇｙの放射線照射後７日目には通常の色素幹細胞は小さく丸い胞体をしているが、異所性に着色した色素細胞樹状の形態をしているのが観察される（ｉ、ｊの矢頭）。（ｋ）〜（ｎ）は放射線照射後のｌａｃＺ陽性細胞を示す。ｌａｃＺ陽性細胞は２回目の毛周期でバルジ領域から姿を消す。（ｋ）、（ｌ）はホールマウント像。（ｋ）、（ｍ）は放射線照射前のマウスのｌａｃＺ染色皮膚。（ｌ）、（ｎ）は放射線照射後のマウスのｌａｃＺ染色皮膚。括弧でバルジ領域（ｂｇ）を示している。（ｏ）は放射線照射後の１回目、２回目、３回目の各毛周期における総毛包あたりのｌａｃＺ陽性細胞の割合を示す。（ｐ）〜（ｓ）は、ゲノム損傷性の薬剤を投与した後のバルジ領域の組織化学的変化を示す。（ｑ）はブスルファン（４０ｍｇ／ｋｇ）を投与した場合。（ｒ）はマイトマイシンC (MitomycinC：４ｍｇ／ｋｇ体重)を投与した場合。（ｓ）は過酸化水素（１％ ｉｎ ＰＢＳ）を投与した場合。各薬剤の投与後６日目に異所性に着色したメラノサイトを確認したが（ｑ〜ｓ）、コントロールでは確認されなかった（ｐ）。各薬剤の投与後２回目の毛周期では白髪が見られたが（ｕ〜ｗ）、コントロールでは見られない（ｔ）。（ｘ）はＤｃｔ−ｌａｃＺマウスの加齢に伴う髭毛のバルジ領域におけるホールマウントｌａｃＺ染色像を示す。樹状の形態をした色素細胞が加齢マウスの毛包のバルジ領域では確認される(矢頭、生後２２カ月)。（ｙ）、（ｚ）は、４２週齢のＸＰＤＲ７２２Ｗ／Ｒ７２２Ｗ マウスとＸＰＤ＋／＋マウスのバルジ領域を示す。ＰＤＲ７２２Ｗ／Ｒ７２２Ｗ マウスでは毛包バルジ部のＫｉｔ＋陽性細胞（ｚ）に色素を有しているが(矢頭)、コントロールマウスでは確認されない（ＸＰＤ＋／＋マウスマウスの矢頭）（ｙ）。\nＡＴＭ ａｎｄ Ｒａｄ３−ｒｅｌａｔｅｄ（ＡＴＲ）、Ｈ２ＡＸ（γ−Ｈ２ＡＸ）、５\n修復されることが知られている（J.Wada Harper et al. Molecular Cell. 28:739-745. 2\n007, Tom Misteli et al. Molecular Cell Biology. 10:243-254. 2009）。そのため、こ\n（Ａｌｔｓｃｈｕｌら， Ｍｅｔｈｏｄｓ ｉｎ Ｅｎｚｙｍｏｌｏｇｙ ２６６：４６\nｓｕｂｅｌら， Ｐｒｏｔｏｃｏｌ ｉｎ Ｍｏｌｅｃｕｌａｒ Ｂｉｏｌｏｇｙ（１９\n働して損傷したＤＮＡが修復されることが知られている（J.Wada Harper et al. Molecul\nar Cell. 28:739-745. 2007, Tom Misteli et al. Molecular Cell Biology. 10:243-254\n以下の配列番号１に示すアミノ酸配列（NCBI Reference Sequence: NP_000042.3 ataxia\ntelangiectasia mutated isoform 1 [Homo sapiens]）を有する。\n1 mslvlndlli ccrqlehdra terkkevekf krlirdpeti khldrhsdsk qgkylnwdav\n61 frflqkyiqk eteclriakp nvsastqasr qkkmqeissl vkyfikcanr raprlkcqel\n121 lnyimdtvkd ssngaiygad csnillkdil svrkywceis qqqwlelfsv yfrlylkpsq\n181 dvhrvlvari ihavtkgccs qtdglnskfl dffskaiqca rqeksssgln hilaaltifl\n241 ktlavnfrir vcelgdeilp tllyiwtqhr lndslkevii elfqlqiyih hpkgaktqek\n301 gayestkwrs ilynlydllv neishigsrg kyssgfrnia vkenlielma dichqvfned\n361 trsleisqsy tttqressdy svpckrkkie lgwevikdhl qksqndfdlv pwlqiatqli\n421 skypaslpnc elspllmils qllpqqrhge rtpyvlrclt evalcqdkrs nlessqksdl\n481 lklwnkiwci tfrgisseqi qaenfgllga iiqgslvevd refwklftgs acrpscpavc\n541 cltlalttsi vpgtvkmgie qnmcevnrsf slkesimkwl lfyqlegdle nstevppilh\n601 snfphlvlek ilvsltmknc kaamnffqsv pecehhqkdk eelsfsevee lflqttfdkm\n661 dfltivrecg iekhqssigf svhqnlkesl drcllglseq llnnysseit nsetlvrcsr\n721 llvgvlgcyc ymgviaeeea ykselfqkak slmqcagesi tlfknktnee frigslrnmm\n781 qlctrclsnc tkkspnkias gfflrlltsk lmndiadick slasfikkpf drgevesmed\n841 dtngnlmeve dqssmnlfnd ypdssvsdan epgesqstig ainplaeeyl skqdllfldm\n901 lkflclcvtt aqtntvsfra adirrkllml idsstleptk slhlhmylml lkelpgeeyp\n961 lpmedvlell kplsnvcsly rrdqdvckti lnhvlhvvkn lgqsnmdsen trdaqgqflt\n1021 vigafwhltk erkyifsvrm alvnclktll eadpyskwai lnvmgkdfpv nevftqflad\n1081 nhhqvrmlaa esinrlfqdt kgdssrllka lplklqqtaf enaylkaqeg mremshsaen\n1141 petldeiynr ksvlltliav vlscspicek qalfalcksv kenglephlv kkvlekvset\n1201 fgyrrledfm ashldylvle wlnlqdteyn lssfpfilln ytniedfyrs cykvliphlv\n1261 irshfdevks ianqiqedwk slltdcfpki lvnilpyfay egtrdsgmaq qretatkvyd\n1321 mlksenllgk qidhlfisnl peivvellmt lhepanssas qstdlcdfsg dldpapnpph\n1381 fpshvikatf ayisnchktk lksileilsk spdsyqkill aiceqaaetn nvykkhrilk\n1441 iyhlfvslll kdiksglgga wafvlrdviy tlihyinqrp scimdvslrs fslccdllsq\n1501 vcqtavtyck dalenhlhvi vgtliplvye qvevqkqvld llkylvidnk dnenlyitik\n1561 lldpfpdhvv fkdlritqqk ikysrgpfsl leeinhflsv svydalpltr leglkdlrrq\n1621 lelhkdqmvd imrasqdnpq dgimvklvvn llqlskmain htgekevlea vgsclgevgp\n1681 idfstiaiqh skdasytkal klfedkelqw tfimltylnn tlvedcvkvr saavtclkni\n1741 latktghsfw eiykmttdpm laylqpfrts rkkflevprf dkenpfegld dinlwiplse\n1801 nhdiwiktlt cafldsggtk ceilqllkpm cevktdfcqt vlpylihdil lqdtneswrn\n1861 llsthvqgff tsclrhfsqt srsttpanld sesehffrcc ldkksqrtml avvdymrrqk\n1921 rpssgtifnd afwldlnyle vakvaqscaa hftallyaei yadkksmddq ekrslafeeg\n1981 sqsttissls ekskeetgis lqdllleiyr sigepdslyg cgggkmlqpi trlrtyehea\n2041 mwgkalvtyd letaipsstr qagiiqalqn lglchilsvy lkgldyenkd wcpeleelhy\n2101 qaawrnmqwd hctsvskeve gtsyheslyn alqslrdref stfyeslkya rvkeveemck\n2161 rslesvysly ptlsrlqaig elesigelfs rsvthrqlse vyikwqkhsq llkdsdfsfq\n2221 epimalrtvi leilmekemd nsqrecikdi ltkhlvelsi lartfkntql peraifqikq\n2281 ynsvscgvse wqleeaqvfw akkeqslals ilkqmikkld ascaannpsl kltyteclrv\n2341 cgnwlaetcl enpavimqty lekavevagn ydgessdelr ngkmkaflsl arfsdtqyqr\n2401 ienymkssef enkqallkra keevgllreh kiqtnrytvk vqreleldel alralkedrk\n2461 rflckaveny incllsgeeh dmwvfrlcsl wlensgvsev ngmmkrdgmk iptykflplm\n2521 yqlaarmgtk mmgglgfhev lnnlisrism dhphhtlfii lalananrde fltkpevarr\n2581 sritknvpkq ssqldedrte aanriictir srrpqmvrsv ealcdayiil anldatqwkt\n2641 qrkginipad qpitklknle dvvvptmeik vdhtgeygnl vtiqsfkaef rlaggvnlpk\n2701 iidcvgsdgk errqlvkgrd dlrqdavmqq vfqmcntllq rntetrkrkl tictykvvpl\n2761 sqrsgvlewc tgtvpigefl vnnedgahkr yrpndfsafq cqkkmmevqk ksfeekyevf\n2821 mdvcqnfqpv fryfcmekfl dpaiwfekrl aytrsvatss ivgyilglgd rhvqniline\n2881 qsaelvhidl gvafeqgkil ptpetvpfrl trdivdgmgi tgvegvfrrc cektmevmrn\n2941 sqetlltive vllydplfdw tmnplkalyl qqrpedetel hptlnaddqe ckrnlsdidq\n3001 sfnkvaervl mrlqeklkgv eegtvlsvgg qvnlliqqai dpknlsrlfp gwkawv//\neference Sequence: NM_000051.3 Homo sapiens ataxia telangiectasia mutated (ＡＴ\nＭ), transcript variant 1, mRNA）に示す塩基配列を有する。\n1 ccggagcccg agccgaaggg cgagccgcaa acgctaagtc gctggccatt ggtggacatg\n61 gcgcaggcgc gtttgctccg acgggccgaa tgttttgggg cagtgttttg agcgcggaga\n121 ccgcgtgata ctggatgcgc atgggcatac cgtgctctgc ggctgcttgg cgttgcttct\n181 tcctccagaa gtgggcgctg ggcagtcacg cagggtttga accggaagcg ggagtaggta\n241 gctgcgtggc taacggagaa aagaagccgt ggccgcggga ggaggcgaga ggagtcggga\n301 tctgcgctgc agccaccgcc gcggttgata ctactttgac cttccgagtg cagtgacagt\n361 gatgtgtgtt ctgaaattgt gaaccatgag tctagtactt aatgatctgc ttatctgctg\n421 ccgtcaacta gaacatgata gagctacaga acgaaagaaa gaagttgaga aatttaagcg\n481 cctgattcga gatcctgaaa caattaaaca tctagatcgg cattcagatt ccaaacaagg\n541 aaaatatttg aattgggatg ctgtttttag atttttacag aaatatattc agaaagaaac\n601 agaatgtctg agaatagcaa aaccaaatgt atcagcctca acacaagcct ccaggcagaa\n661 aaagatgcag gaaatcagta gtttggtcaa atacttcatc aaatgtgcaa acagaagagc\n721 acctaggcta aaatgtcaag aactcttaaa ttatatcatg gatacagtga aagattcatc\n781 taatggtgct atttacggag ctgattgtag caacatacta ctcaaagaca ttctttctgt\n841 gagaaaatac tggtgtgaaa tatctcagca acagtggtta gaattgttct ctgtgtactt\n901 caggctctat ctgaaacctt cacaagatgt tcatagagtt ttagtggcta gaataattca\n961 tgctgttacc aaaggatgct gttctcagac tgacggatta aattccaaat ttttggactt\n1021 tttttccaag gctattcagt gtgcgagaca agaaaagagc tcttcaggtc taaatcatat\n1081 cttagcagct cttactatct tcctcaagac tttggctgtc aactttcgaa ttcgagtgtg\n1141 tgaattagga gatgaaattc ttcccacttt gctttatatt tggactcaac ataggcttaa\n1201 tgattcttta aaagaagtca ttattgaatt atttcaactg caaatttata tccatcatcc\n1261 gaaaggagcc aaaacccaag aaaaaggtgc ttatgaatca acaaaatgga gaagtatttt\n1321 atacaactta tatgatctgc tagtgaatga gataagtcat ataggaagta gaggaaagta\n1381 ttcttcagga tttcgtaata ttgccgtcaa agaaaatttg attgaattga tggcagatat\n1441 ctgtcaccag gtttttaatg aagataccag atccttggag atttctcaat cttacactac\n1501 tacacaaaga gaatctagtg attacagtgt cccttgcaaa aggaagaaaa tagaactagg\n1561 ctgggaagta ataaaagatc accttcagaa gtcacagaat gattttgatc ttgtgccttg\n1621 gctacagatt gcaacccaat taatatcaaa gtatcctgca agtttaccta actgtgagct\n1681 gtctccatta ctgatgatac tatctcagct tctaccccaa cagcgacatg gggaacgtac\n1741 accatatgtg ttacgatgcc ttacggaagt tgcattgtgt caagacaaga ggtcaaacct\n1801 agaaagctca caaaagtcag atttattaaa actctggaat aaaatttggt gtattacctt\n1861 tcgtggtata agttctgagc aaatacaagc tgaaaacttt ggcttacttg gagccataat\n1921 tcagggtagt ttagttgagg ttgacagaga attctggaag ttatttactg ggtcagcctg\n1981 cagaccttca tgtcctgcag tatgctgttt gactttggca ctgaccacca gtatagttcc\n2041 aggaacggta aaaatgggaa tagagcaaaa tatgtgtgaa gtaaatagaa gcttttcttt\n2101 aaaggaatca ataatgaaat ggctcttatt ctatcagtta gagggtgact tagaaaatag\n2161 cacagaagtg cctccaattc ttcacagtaa ttttcctcat cttgtactgg agaaaattct\n2221 tgtgagtctc actatgaaaa actgtaaagc tgcaatgaat tttttccaaa gcgtgccaga\n2281 atgtgaacac caccaaaaag ataaagaaga actttcattc tcagaagtag aagaactatt\n2341 tcttcagaca acttttgaca agatggactt tttaaccatt gtgagagaat gtggtataga\n2401 aaagcaccag tccagtattg gcttctctgt ccaccagaat ctcaaggaat cactggatcg\n2461 ctgtcttctg ggattatcag aacagcttct gaataattac tcatctgaga ttacaaattc\n2521 agaaactctt gtccggtgtt cacgtctttt ggtgggtgtc cttggctgct actgttacat\n2581 gggtgtaata gctgaagagg aagcatataa gtcagaatta ttccagaaag ccaagtctct\n2641 aatgcaatgt gcaggagaaa gtatcactct gtttaaaaat aagacaaatg aggaattcag\n2701 aattggttcc ttgagaaata tgatgcagct atgtacacgt tgcttgagca actgtaccaa\n2761 gaagagtcca aataagattg catctggctt tttcctgcga ttgttaacat caaagctaat\n2821 gaatgacatt gcagatattt gtaaaagttt agcatccttc atcaaaaagc catttgaccg\n2881 tggagaagta gaatcaatgg aagatgatac taatggaaat ctaatggagg tggaggatca\n2941 gtcatccatg aatctattta acgattaccc tgatagtagt gttagtgatg caaacgaacc\n3001 tggagagagc caaagtacca taggtgccat taatccttta gctgaagaat atctgtcaaa\n3061 gcaagatcta cttttcttag acatgctcaa gttcttgtgt ttgtgtgtaa ctactgctca\n3121 gaccaatact gtgtccttta gggcagctga tattcggagg aaattgttaa tgttaattga\n3181 ttctagcacg ctagaaccta ccaaatccct ccacctgcat atgtatctaa tgcttttaaa\n3241 ggagcttcct ggagaagagt accccttgcc aatggaagat gttcttgaac ttctgaaacc\n3301 actatccaat gtgtgttctt tgtatcgtcg tgaccaagat gtttgtaaaa ctattttaaa\n3361 ccatgtcctt catgtagtga aaaacctagg tcaaagcaat atggactctg agaacacaag\n3421 ggatgctcaa ggacagtttc ttacagtaat tggagcattt tggcatctaa caaaggagag\n3481 gaaatatata ttctctgtaa gaatggccct agtaaattgc cttaaaactt tgcttgaggc\n3541 tgatccttat tcaaaatggg ccattcttaa tgtaatggga aaagactttc ctgtaaatga\n3601 agtatttaca caatttcttg ctgacaatca tcaccaagtt cgcatgttgg ctgcagagtc\n3661 aatcaataga ttgttccagg acacgaaggg agattcttcc aggttactga aagcacttcc\n3721 tttgaagctt cagcaaacag cttttgaaaa tgcatacttg aaagctcagg aaggaatgag\n3781 agaaatgtcc catagtgctg agaaccctga aactttggat gaaatttata atagaaaatc\n3841 tgttttactg acgttgatag ctgtggtttt atcctgtagc cctatctgcg aaaaacaggc\n3901 tttgtttgcc ctgtgtaaat ctgtgaaaga gaatggatta gaacctcacc ttgtgaaaaa\n3961 ggttttagag aaagtttctg aaacttttgg atatagacgt ttagaagact ttatggcatc\n4021 tcatttagat tatctggttt tggaatggct aaatcttcaa gatactgaat acaacttatc\n4081 ttcttttcct tttattttat taaactacac aaatattgag gatttctata gatcttgtta\n4141 taaggttttg attccacatc tggtgattag aagtcatttt gatgaggtga agtccattgc\n4201 taatcagatt caagaggact ggaaaagtct tctaacagac tgctttccaa agattcttgt\n4261 aaatattctt ccttattttg cctatgaggg taccagagac agtgggatgg cacagcaaag\n4321 agagactgct accaaggtct atgatatgct taaaagtgaa aacttattgg gaaaacagat\n4381 tgatcactta ttcattagta atttaccaga gattgtggtg gagttattga tgacgttaca\n4441 tgagccagca aattctagtg ccagtcagag cactgacctc tgtgactttt caggggattt\n4501 ggatcctgct cctaatccac ctcattttcc atcgcatgtg attaaagcaa catttgccta\n4561 tatcagcaat tgtcataaaa ccaagttaaa aagcatttta gaaattcttt ccaaaagccc\n4621 tgattcctat cagaaaattc ttcttgccat atgtgagcaa gcagctgaaa caaataatgt\n4681 ttataagaag cacagaattc ttaaaatata tcacctgttt gttagtttat tactgaaaga\n4741 tataaaaagt ggcttaggag gagcttgggc ctttgttctt cgagacgtta tttatacttt\n4801 gattcactat atcaaccaaa ggccttcttg tatcatggat gtgtcattac gtagcttctc\n4861 cctttgttgt gacttattaa gtcaggtttg ccagacagcc gtgacttact gtaaggatgc\n4921 tctagaaaac catcttcatg ttattgttgg tacacttata ccccttgtgt atgagcaggt\n4981 ggaggttcag aaacaggtat tggacttgtt gaaatactta gtgatagata acaaggataa\n5041 tgaaaacctc tatatcacga ttaagctttt agatcctttt cctgaccatg ttgtttttaa\n5101 ggatttgcgt attactcagc aaaaaatcaa atacagtaga ggaccctttt cactcttgga\n5161 ggaaattaac cattttctct cagtaagtgt ttatgatgca cttccattga caagacttga\n5221 aggactaaag gatcttcgaa gacaactgga actacataaa gatcagatgg tggacattat\n5281 gagagcttct caggataatc cgcaagatgg gattatggtg aaactagttg tcaatttgtt\n5341 gcagttatcc aagatggcaa taaaccacac tggtgaaaaa gaagttctag aggctgttgg\n5401 aagctgcttg ggagaagtgg gtcctataga tttctctacc atagctatac aacatagtaa\n5461 agatgcatct tataccaagg cccttaagtt atttgaagat aaagaacttc agtggacctt\n5521 cataatgctg acctacctga ataacacact ggtagaagat tgtgtcaaag ttcgatcagc\n5581 agctgttacc tgtttgaaaa acattttagc cacaaagact ggacatagtt tctgggagat\n5641 ttataagatg acaacagatc caatgctggc ctatctacag ccttttagaa catcaagaaa\n5701 aaagttttta gaagtaccca gatttgacaa agaaaaccct tttgaaggcc tggatgatat\n5761 aaatctgtgg attcctctaa gtgaaaatca tgacatttgg ataaagacac tgacttgtgc\n5821 ttttttggac agtggaggca caaaatgtga aattcttcaa ttattaaagc caatgtgtga\n5881 agtgaaaact gacttttgtc agactgtact tccatacttg attcatgata ttttactcca\n5941 agatacaaat gaatcatgga gaaatctgct ttctacacat gttcagggat ttttcaccag\n6001 ctgtcttcga cacttctcgc aaacgagccg atccacaacc cctgcaaact tggattcaga\n6061 gtcagagcac tttttccgat gctgtttgga taaaaaatca caaagaacaa tgcttgctgt\n6121 tgtggactac atgagaagac aaaagagacc ttcttcagga acaattttta atgatgcttt\n6181 ctggctggat ttaaattatc tagaagttgc caaggtagct cagtcttgtg ctgctcactt\n6241 tacagcttta ctctatgcag aaatctatgc agataagaaa agtatggatg atcaagagaa\n6301 aagaagtctt gcatttgaag aaggaagcca gagtacaact atttctagct tgagtgaaaa\n6361 aagtaaagaa gaaactggaa taagtttaca ggatcttctc ttagaaatct acagaagtat\n6421 aggggagcca gatagtttgt atggctgtgg tggagggaag atgttacaac ccattactag\n6481 actacgaaca tatgaacacg aagcaatgtg gggcaaagcc ctagtaacat atgacctcga\n6541 aacagcaatc ccctcatcaa cacgccaggc aggaatcatt caggccttgc agaatttggg\n6601 actctgccat attctttccg tctatttaaa aggattggat tatgaaaata aagactggtg\n6661 tcctgaacta gaagaacttc attaccaagc agcatggagg aatatgcagt gggaccattg\n6721 cacttccgtc agcaaagaag tagaaggaac cagttaccat gaatcattgt acaatgctct\n6781 acaatctcta agagacagag aattctctac attttatgaa agtctcaaat atgccagagt\n6841 aaaagaagtg gaagagatgt gtaagcgcag ccttgagtct gtgtattcgc tctatcccac\n6901 acttagcagg ttgcaggcca ttggagagct ggaaagcatt ggggagcttt tctcaagatc\n6961 agtcacacat agacaactct ctgaagtata tattaagtgg cagaaacact cccagcttct\n7021 caaggacagt gattttagtt ttcaggagcc tatcatggct ctacgcacag tcattttgga\n7081 gatcctgatg gaaaaggaaa tggacaactc acaaagagaa tgtattaagg acattctcac\n7141 caaacacctt gtagaactct ctatactggc cagaactttc aagaacactc agctccctga\n7201 aagggcaata tttcaaatta aacagtacaa ttcagttagc tgtggagtct ctgagtggca\n7261 gctggaagaa gcacaagtat tctgggcaaa aaaggagcag agtcttgccc tgagtattct\n7321 caagcaaatg atcaagaagt tggatgccag ctgtgcagcg aacaatccca gcctaaaact\n7381 tacatacaca gaatgtctga gggtttgtgg caactggtta gcagaaacgt gcttagaaaa\n7441 tcctgcggtc atcatgcaga cctatctaga aaaggcagta gaagttgctg gaaattatga\n7501 tggagaaagt agtgatgagc taagaaatgg aaaaatgaag gcatttctct cattagcccg\n7561 gttttcagat actcaatacc aaagaattga aaactacatg aaatcatcgg aatttgaaaa\n7621 caagcaagct ctcctgaaaa gagccaaaga ggaagtaggt ctccttaggg aacataaaat\n7681 tcagacaaac agatacacag taaaggttca gcgagagctg gagttggatg aattagccct\n7741 gcgtgcactg aaagaggatc gtaaacgctt cttatgtaaa gcagttgaaa attatatcaa\n7801 ctgcttatta agtggagaag aacatgatat gtgggtattc cgactttgtt ccctctggct\n7861 tgaaaattct ggagtttctg aagtcaatgg catgatgaag agagacggaa tgaagattcc\n7921 aacatataaa tttttgcctc ttatgtacca attggctgct agaatgggga ccaagatgat\n7981 gggaggccta ggatttcatg aagtcctcaa taatctaatc tctagaattt caatggatca\n8041 cccccatcac actttgttta ttatactggc cttagcaaat gcaaacagag atgaatttct\n8101 gactaaacca gaggtagcca gaagaagcag aataactaaa aatgtgccta aacaaagctc\n8161 tcagcttgat gaggatcgaa cagaggctgc aaatagaata atatgtacta tcagaagtag\n8221 gagacctcag atggtcagaa gtgttgaggc actttgtgat gcttatatta tattagcaaa\n8281 cttagatgcc actcagtgga agactcagag aaaaggcata aatattccag cagaccagcc\n8341 aattactaaa cttaagaatt tagaagatgt tgttgtccct actatggaaa ttaaggtgga\n8401 ccacacagga gaatatggaa atctggtgac tatacagtca tttaaagcag aatttcgctt\n8461 agcaggaggt gtaaatttac caaaaataat agattgtgta ggttccgatg gcaaggagag\n8521 gagacagctt gttaagggcc gtgatgacct gagacaagat gctgtcatgc aacaggtctt\n8581 ccagatgtgt aatacattac tgcagagaaa cacggaaact aggaagagga aattaactat\n8641 ctgtacttat aaggtggttc ccctctctca gcgaagtggt gttcttgaat ggtgcacagg\n8701 aactgtcccc attggtgaat ttcttgttaa caatgaagat ggtgctcata aaagatacag\n8761 gccaaatgat ttcagtgcct ttcagtgcca aaagaaaatg atggaggtgc aaaaaaagtc\n8821 ttttgaagag aaatatgaag tcttcatgga tgtttgccaa aattttcaac cagttttccg\n8881 ttacttctgc atggaaaaat tcttggatcc agctatttgg tttgagaagc gattggctta\n8941 tacgcgcagt gtagctactt cttctattgt tggttacata cttggacttg gtgatagaca\n9001 tgtacagaat atcttgataa atgagcagtc agcagaactt gtacatatag atctaggtgt\n9061 tgcttttgaa cagggcaaaa tccttcctac tcctgagaca gttcctttta gactcaccag\n9121 agatattgtg gatggcatgg gcattacggg tgttgaaggt gtcttcagaa gatgctgtga\n9181 gaaaaccatg gaagtgatga gaaactctca ggaaactctg ttaaccattg tagaggtcct\n9241 tctatatgat ccactctttg actggaccat gaatcctttg aaagctttgt atttacagca\n9301 gaggccggaa gatgaaactg agcttcaccc tactctgaat gcagatgacc aagaatgcaa\n9361 acgaaatctc agtgatattg accagagttt caacaaagta gctgaacgtg tcttaatgag\n9421 actacaagag aaactgaaag gagtggaaga aggcactgtg ctcagtgttg gtggacaagt\n9481 gaatttgctc atacagcagg ccatagaccc caaaaatctc agccgacttt tcccaggatg\n9541 gaaagcttgg gtgtgatctt cagtatatga attacccttt cattcagcct ttagaaatta\n9601 tattttagcc tttattttta acctgccaac atactttaag tagggattaa tatttaagtg\n9661 aactattgtg ggtttttttg aatgttggtt ttaatacttg atttaatcac cactcaaaaa\n9721 tgttttgatg gtcttaagga acatctctgc tttcactctt tagaaataat ggtcattcgg\n9781 gctgggcgca gcggctcacg cctgtaatcc cagcactttg ggaggccgag gtgagcggat\n9841 cacaaggtca ggagttcgag accagcctgg ccaagagacc agcctggcca gtatggtgaa\n9901 accctgtctc tactaaaaat acaaaaatta gccgagcatg gtggcgggca cctgtaatcc\n9961 cagctactcg agaggctgag gcaggagaat ctcttgaacc tgggaggtga aggttgctgt\n10021 gggccaaaat catgccattg cactccagcc tgggtgacaa gagcgaaact ccatctcaaa\n10081 aaaaaaaaaa aaaaaacaga aacgtatttg gatttttcct agtaagatca ctcagtgtta\n10141 ctaaataatg aagttgttat ggagaacaaa tttcaaagac acagttagtg tagttactat\n10201 ttttttaagt gtgtattaaa acttctcatt ctattctctt tatcttttaa gcccttctgt\n10261 actgtccatg tatgttatct ttctgtgata acttcataga ttgccttcta gttcatgaat\n10321 tctcttgtca gatgtatata atctctttta ccctatccat tgggcttctt ctttcagaaa\n10381 ttgtttttca tttctaatta tgcatcattt ttcagatctc tgtttcttga tgtcattttt\n10441 aatgtttttt taatgttttt tatgtcacta attattttaa atgtctgtac ttgatagaca\n10501 ctgtaatagt tctattaaat ttagttcctg ctgtttatat ctgttgattt ttgtatttga\n10561 taggctgttc atccagtttt gtctttttga aaagtgagtt tattttcagc aaggctttat\n10621 ctatgggaat cttgagtgtc tgtttatgtc atattcccag ggctgttgct gcacacaagc\n10681 ccattcttat tttaatttct tggctttagg gtttccatac ctgaagtgta gcataaatac\n10741 tgataggaga tttcccaggc caaggcaaac acacttcctc ctcatctcct tgtgctagtg\n10801 ggcagaatat ttgattgatg cctttttcac tgagagtata agcttccatg tgtcccacct\n10861 ttatggcagg ggtggaagga ggtacattta attcccactg cctgcctttg gcaagccctg\n10921 ggttctttgc tccccatata gatgtctaag ctaaaagccg tgggttaatg agactggcaa\n10981 attgttccag gacagctaca gcatcagctc acatattcac ctctctggtt tttcattccc\n11041 ctcatttttt tctgagacag agtcttgctc tgtcacccag gctggagtgc agtggcatga\n11101 tctcagctca ctgaaacctc tgcctcctgg gttcaagcaa ttctcctgcc tcagcctccc\n11161 gagtagctgg gactacaggc gtgtgccaac acgcccggct aattttttgt atttttatta\n11221 gagacggagt ttcaccgtgt tagccaggat ggtctcgatc gcttgacctc gtgatccacc\n11281 ctcctcggcc tcccaaagtg ctgggattac aggtgtgagc caccgcgccc ggcctcattc\n11341 ccctcatttt tgaccgtaag gatttcccct ttcttgtaag ttctgctatg tatttaaaag\n11401 aatgttttct acattttatc cagcatttct ctgtgttctg ttggaaggga agggcttagg\n11461 tatctagttt gatacatagg tagaagtgga acatttctct gtcccccagc tgtcatcata\n11521 taagataaac atcagataaa aagccacctg aaagtaaaac tactgactcg tgtattagtg\n11581 agtataatct cttctccatc cttaggaaaa tgttcatccc agctgcggag attaacaaat\n11641 gggtgattga gctttctcct cgtatttgga ccttgaaggt tatataaatt tttttcttat\n11701 gaagagttgg catttctttt tattgccaat ggcaggcact cattcatatt tgatctcctc\n11761 accttcccct cccctaaaac caatctccag aactttttgg actataaatt tcttggtttg\n11821 acttctggag aactgttcag aatattactt tgcatttcaa attacaaact taccttggtg\n11881 tatctttttc ttacaagctg cctaaatgaa tatttggtat atattggtag ttttattact\n11941 atagtaaatc aaggaaatgc agtaaactta aaatgtcttt aagaaagccc tgaaatcttc\n12001 atgggtgaaa ttagaaatta tcaactagat aatagtatag ataaatgaat ttgtagctaa\n12061 ttcttgctag ttgttgcatc cagagagctt tgaataacat cattaatcta ctctttagcc\n12121 ttgcatggta tgctatgagg ctcctgttct gttcaagtat tctaatcaat ggctttgaaa\n12181 agtttatcaa atttacatac agatcacaag cctaggagaa ataactaatt cacagatgac\n12241 agaattaaga ttataaaaga tttttttttt gtaattttag tagagacagg gttgccattg\n12301 tattccagcc ttggcgacag agcaagactc tgcctcaaaa aaaaaaaaaa aaaggttttg\n12361 gcaagctgga actctttctg caaatgacta agatagaaaa ctgccaagga caaatgagga\n12421 gtagttagat tttgaaaata ttaatcatag aatagttgtt gtatgctaag tcactgaccc\n12481 atattatgta cagcatttct gatctttact ttgcaagatt agtgatacta tcccaataca\n12541 ctgctggaga aatcagaatt tggagaaata agttgtccaa ggcaagaaga tagtaaatta\n12601 taagtacaag tgtaatatgg acagtatcta acttgaaaag atttcaggcg aaaagaatct\n12661 ggggtttgcc agtcagttgc tcaaaaggtc aatgaaaacc aaatagtgaa gctatcagag\n12721 aagctaataa attatagact gcttgaacag ttgtgtccag attaagggag ataatagctt\n12781 tcccacccta ctttgtgcag gtcatacctc cccaaagtgt ttacctaatc agtaggttca\n12841 caaactcttg gtcattatag tatatgccta aaatgtatgc acttaggaat gctaaaaatt\n12901 taaatatggt ctaaagcaaa taaaagcaaa gaggaaaaac tttggacagc gtaaagacta\n12961 gaatagtctt ttaaaaagaa agccagtata ttggtttgaa atatagagat gtgtcccaat\n13021 ttcaagtatt ttaattgcac cttaatgaaa ttatctattt tctatagatt ttagtactat\n13081 tgaatgtatt actttactgt tacctgaatt tattataaag tgtttttgaa taaataattc\nく知られている（J.Wada Harper et al. Molecular Cell. 28:739-745. 2007, Tom Miste\nli et al. Molecular Cell Biology. 10:243-254. 2009）。すなわち、ＡＴＭ、ＡＴＲの\n役割は部分的に重複し、共同して働くことがよく知られている（J.Wada Harper et al. M\nolecular Cell. 28:739-745. 2007, Tom Misteli et al. Molecular Cell Biology. 10:2\n以下の配列番号３（NCBI Reference Sequence: NP_001175.2 ataxia telangiectasia and\nRad3 related protein [Homo sapiens]）に示すアミノ酸配列を有する。\n1 mgehglelas mipalrelgs atpeeyntvv qkprqilcqf idriltdvnv vavelvkktd\n61 sqptsvmlld fiqhimkssp lmfvnvsgsh eakgsciefs nwiitrllri aatpschllh\n121 kkicevicsl lflfkskspa ifgvltkell qlfedlvylh rrnvmghave wpvvmsrfls\n181 qldehmgylq saplqlmsmq nlefievtll mvltriiaiv ffrrqelllw qigcvlleyg\n241 spkikslais fltelfqlgg lpaqpastff ssflellkhl vemdtdqlkl yeeplsklik\n301 tlfpfeaeay rniepvylnm lleklcvmfe dgvlmrlksd llkaalchll qyflkfvpag\n361 yesalqvrkv yvrnickall dvlgievdae yllgplyaal kmesmeiiee iqcqtqqenl\n421 ssnsdgispk rrrlssslnp skrapkqtee ikhvdmnqks ilwsalkqka eslqisleys\n481 glknpvieml egiavvlqlt alctvhcshq nmncrtfkdc qhkskkkpsv vitwmsldfy\n541 tkvlkscrsl lesvqkldle atidkvvkiy daliymqvns sfedhiledl cgmlslpwiy\n601 shsddgclkl ttfaanlltl scrisdsysp qaqsrcvfll tlfprrifle wrtavynwal\n661 qssheviras cvsgffillq qqnscnrvpk ilidkvkdds divkkefasi lgqlvctlhg\n721 mfyltsslte pfsehghvdl fcrnlkatsq hecsssqlka svckpflfll kkkipspvkl\n781 afidnlhhlc khldfredet dvkavlgtll nlmedpdkdv rvafsgnikh ilesldsedg\n841 fikelfvlrm keaythaqis rnnelkdtli lttgdigraa kgdlvpfall hllhcllsks\n901 asvsgaayte iralvaaksv klqsffsqyk kpicqflves lhssqmtalp ntpcqnadvr\n961 kqdvahqrem alntlseian vfdfpdlnrf ltrtlqvllp dlaakaspaa salirtlgkq\n1021 lnvnrreili nnfkyifshl vcscskdele ralhylknet eielgsllrq dfqglhnell\n1081 lrigehyqqv fnglsilasf assddpyqgp rdiispelma dylqpkllgi laffnmqlls\n1141 ssvgiedkkm alnslmslmk lmgpkhvssv rvkmmttlrt glrfkddfpe lccrawdcfv\n1201 rcldhaclgs llshvivall plihiqpket aaifhyliie nrdavqdflh eiyflpdhpe\n1261 lkkikavlqe yrketsestd lqttlqlsmk aiqhenvdvr ihaltslket lyknqeklik\n1321 yatdsetvep iisqlvtvll kgcqdansqa rllcgeclge lgaidpgrld fsttetqgkd\n1381 ftfvtgveds sfaygllmel traylayadn sraqdsaaya iqellsiydc remetngpgh\n1441 qlwrrfpehv reilephlnt rykssqkstd wsgvkkpiyl sklgsnfaew saswagylit\n1501 kvrhdlaski ftccsimmkh dfkvtiyllp hilvyvllgc nqedqqevya eimavlkhdd\n1561 qhtintqdia sdlcqlstqt vfsmldhltq warhkfqalk aekcphsksn rnkvdsmvst\n1621 vdyedyqsvt rfldlipqdt lavasfrska ytravmhfes fitekkqniq ehlgflqkly\n1681 aamhepdgva gvsairkaep slkeqilehe slgllrdata cydraiqlep dqiihyhgvv\n1741 ksmlglgqls tvitqvngvh anrsewtdel ntyrveaawk lsqwdlveny laadgksttw\n1801 svrlgqllls akkrditafy dslklvraeq ivplsaasfe rgsyqrgyey ivrlhmlcel\n1861 ehsikplfqh spgdssqeds lnwvarlemt qnsyrakepi lalrrallsl nkrpdynemv\n1921 gecwlqsarv arkaghhqta ynallnages rlaelyvera kwlwskgdvh qalivlqkgv\n1981 elcfpenetp pegknmlihg ramllvgrfm eetanfesna imkkykdvta clpewedghf\n2041 ylakyydklm pmvtdnkmek qgdliryivl hfgrslqygn qfiyqsmprm ltlwldygtk\n2101 ayewekagrs drvqmrndlg kinkviteht nylapyqflt afsqlisric hshdevfvvl\n2161 meiiakvfla ypqqamwmmt avskssypmr vnrckeilnk aihmkkslek fvgdatrltd\n2221 kllelcnkpv dgssstlsms thfkmlkklv eeatfseili plqsvmiptl psilgthanh\n2281 ashepfpghw ayiagfddmv eilaslqkpk kislkgsdgk fyimmckpkd dlrkdcrlme\n2341 fnslinkclr kdaesrrrel hirtyavipl ndecgiiewv nntaglrpil tklykekgvy\n2401 mtgkelrqcm lpksaalsek lkvfrefllp rhppifhewf lrtfpdptsw yssrsaycrs\n2461 tavmsmvgyi lglgdrhgen ilfdsltgec vhvdfnclfn kgetfevpei vpfrlthnmv\n2521 ngmgpmgteg lfrracevtm rlmrdqrepl msvlktflhd plvewskpvk ghskaplnet\n2581 gevvnekakt hvldieqrlq gviktrnrvt glplsieghv hyliqeatde nllcqmylgw\n基配列（NCBI Reference Sequence: NM_001184.3 Homo sapiens ataxia telangiectasia\nand Rad3 related (ATR), mRNA）を有する。\n1 ttccgggagg agttttggcc tccacacggc tccgtcgggc gccgcgctct tccggcagcg\n61 gtagctttgg agacgccggg aacccgcgtt ggcgtggttg actagtgcct cgcagcctca\n121 gcatggggga acatggcctg gagctggctt ccatgatccc cgccctgcgg gagctgggca\n181 gtgccacacc agaggaatat aatacagttg tacagaagcc aagacaaatt ctgtgtcaat\n241 tcattgaccg gatacttaca gatgtaaatg ttgttgctgt agaacttgta aagaaaactg\n301 actctcagcc aacctccgtg atgttgcttg atttcatcca gcatatcatg aaatcctccc\n361 cacttatgtt tgtaaatgtg agtggaagcc atgaggccaa aggcagttgt attgaattca\n421 gtaattggat cataacgaga cttctgcgga ttgcagcaac tccctcctgt catttgttac\n481 acaagaaaat ctgtgaagtc atctgttcat tattatttct ttttaaaagc aagagtcctg\n541 ctatttttgg ggtactcaca aaagaattat tacaactttt tgaagacttg gtttacctcc\n601 atagaagaaa tgtgatgggt catgctgtgg aatggccagt ggtcatgagc cgatttttaa\n661 gtcaattaga tgaacacatg ggatatttac aatcagctcc tttgcagttg atgagtatgc\n721 aaaatttaga atttattgaa gtcactttat taatggttct tactcgtatt attgcaattg\n781 tgttttttag aaggcaagaa ctcttacttt ggcagatagg ttgtgttctg ctagagtatg\n841 gtagtccaaa aattaaatcc ctagcaatta gctttttaac agaacttttt cagcttggag\n901 gactaccagc acaaccagct agcacttttt tcagctcatt tttggaatta ttaaaacacc\n961 ttgtagaaat ggatactgac caattgaaac tctatgaaga gccattatca aagctgataa\n1021 agacactatt tccctttgaa gcagaagctt atagaaatat tgaacctgtc tatttaaata\n1081 tgctgctgga aaaactctgt gtcatgtttg aagacggtgt gctcatgcgg cttaagtctg\n1141 atttgctaaa agcagctttg tgccatttac tgcagtattt ccttaaattt gtgccagctg\n1201 ggtatgaatc tgctttacaa gtcaggaagg tctatgtgag aaatatttgt aaagctcttt\n1261 tggatgtgct tggaattgag gtagatgcag agtacttgtt gggcccactt tatgcagctt\n1321 tgaaaatgga aagtatggaa atcattgagg agattcaatg ccaaactcaa caggaaaacc\n1381 tcagcagtaa tagtgatgga atatcaccca aaaggcgtcg tctcagctcg tctctaaacc\n1441 cttctaaaag agcaccaaaa cagactgagg aaattaaaca tgtggacatg aaccaaaaga\n1501 gcatattatg gagtgcactg aaacagaaag ctgaatccct tcagatttcc cttgaataca\n1561 gtggcctaaa gaatcctgtt attgagatgt tagaaggaat tgctgttgtc ttacaactga\n1621 ctgctctgtg tactgttcat tgttctcatc aaaacatgaa ctgccgtact ttcaaggact\n1681 gtcaacataa atccaagaag aaaccttctg tagtgataac ttggatgtca ttggattttt\n1741 acacaaaagt gcttaagagc tgtagaagtt tgttagaatc tgttcagaaa ctggacctgg\n1801 aggcaaccat tgataaggtg gtgaaaattt atgatgcttt gatttatatg caagtaaaca\n1861 gttcatttga agatcatatc ctggaagatt tatgtggtat gctctcactt ccatggattt\n1921 attcccattc tgatgatggc tgtttaaagt tgaccacatt tgccgctaat cttctaacat\n1981 taagctgtag gatttcagat agctattcac cacaggcaca atcacgatgt gtgtttcttc\n2041 tgactctgtt tccaagaaga atattccttg agtggagaac agcagtttac aactgggccc\n2101 tgcagagctc ccatgaagta atccgggcta gttgtgttag tggatttttt atcttattgc\n2161 agcagcagaa ttcttgtaac agagttccca agattcttat agataaagtc aaagatgatt\n2221 ctgacattgt caagaaagaa tttgcttcta tacttggtca acttgtctgt actcttcacg\n2281 gcatgtttta tctgacaagt tctttaacag aacctttctc tgaacacgga catgtggacc\n2341 tcttctgtag gaacttgaaa gccacttctc aacatgaatg ttcatcttct caactaaaag\n2401 cttctgtctg caagccattc cttttcctac tgaaaaaaaa aatacctagt ccagtaaaac\n2461 ttgctttcat agataatcta catcatcttt gtaagcatct tgattttaga gaagatgaaa\n2521 cagatgtaaa agcagttctt ggaactttat taaatttaat ggaagatcca gacaaagatg\n2581 ttagagtggc ttttagtgga aatatcaagc acatattgga atccttggac tctgaagatg\n2641 gatttataaa ggagcttttt gtcttaagaa tgaaggaagc atatacacat gcccaaatat\n2701 caagaaataa tgagctgaag gataccttga ttcttacaac aggggatatt ggaagggccg\n2761 caaaaggaga tttggtacca tttgcactct tacacttatt gcattgtttg ttatccaagt\n2821 cagcatctgt ctctggagca gcatacacag aaattagagc tctggttgca gctaaaagtg\n2881 ttaaactgca aagttttttc agccagtata agaaacccat ctgtcagttt ttggtagaat\n2941 cccttcactc tagtcagatg acagcacttc cgaatactcc atgccagaat gctgacgtgc\n3001 gaaaacaaga tgtggctcac cagagagaaa tggctttaaa tacgttgtct gaaattgcca\n3061 acgttttcga ctttcctgat cttaatcgtt ttcttactag gacattacaa gttctactac\n3121 ctgatcttgc tgccaaagca agccctgcag cttctgctct cattcgaact ttaggaaaac\n3181 aattaaatgt caatcgtaga gagattttaa taaacaactt caaatatatt ttttctcatt\n3241 tggtctgttc ttgttccaaa gatgaattag aacgtgccct tcattatctg aagaatgaaa\n3301 cagaaattga actggggagc ctgttgagac aagatttcca aggattgcat aatgaattat\n3361 tgctgcgtat tggagaacac tatcaacagg tttttaatgg tttgtcaata cttgcctcat\n3421 ttgcatccag tgatgatcca tatcagggcc cgagagatat catatcacct gaactgatgg\n3481 ctgattattt acaacccaaa ttgttgggca ttttggcttt ttttaacatg cagttactga\n3541 gctctagtgt tggcattgaa gataagaaaa tggccttgaa cagtttgatg tctttgatga\n3601 agttaatggg acccaaacat gtcagttctg tgagggtgaa gatgatgacc acactgagaa\n3661 ctggccttcg attcaaggat gattttcctg aattgtgttg cagagcttgg gactgctttg\n3721 ttcgctgcct ggatcatgct tgtctgggct cccttctcag tcatgtaata gtagctttgt\n3781 tacctcttat acacatccag cctaaagaaa ctgcagctat cttccactac ctcataattg\n3841 aaaacaggga tgctgtgcaa gattttcttc atgaaatata ttttttacct gatcatccag\n3901 aattaaaaaa gataaaagcc gttctccagg aatacagaaa ggagacctct gagagcactg\n3961 atcttcagac aactcttcag ctctctatga aggccattca acatgaaaat gtcgatgttc\n4021 gtattcatgc tcttacaagc ttgaaggaaa ccttgtataa aaatcaggaa aaactgataa\n4081 agtatgcaac agacagtgaa acagtagaac ctattatctc acagttggtg acagtgcttt\n4141 tgaaaggttg ccaagatgca aactctcaag ctcggttgct ctgtggggaa tgtttagggg\n4201 aattgggggc gatagatcca ggtcgattag atttctcaac aactgaaact caaggaaaag\n4261 attttacatt tgtgactgga gtagaagatt caagctttgc ctatggatta ttgatggagc\n4321 taacaagagc ttaccttgcg tatgctgata atagccgagc tcaagattca gctgcctatg\n4381 ccattcagga gttgctttct atttatgact gtagagagat ggagaccaac ggcccaggtc\n4441 accaattgtg gaggagattt cctgagcatg ttcgggaaat actagaacct catctaaata\n4501 ccagatacaa gagttctcag aagtcaaccg attggtctgg agtaaagaag ccaatttact\n4561 taagtaaatt gggtagtaac tttgcagaat ggtcagcatc ttgggcaggt tatcttatta\n4621 caaaggttcg acatgatctt gccagtaaaa ttttcacctg ctgtagcatt atgatgaagc\n4681 atgatttcaa agtgaccatc tatcttcttc cacatattct ggtgtatgtc ttactgggtt\n4741 gtaatcaaga agatcagcag gaggtttatg cagaaattat ggcagttcta aagcatgacg\n4801 atcagcatac cataaatacc caagacattg catctgatct gtgtcaactc agtacacaga\n4861 ctgtgttctc catgcttgac catctcacac agtgggcaag gcacaaattt caggcactga\n4921 aagctgagaa atgtccacac agcaaatcaa acagaaataa ggtagactca atggtatcta\n4981 ctgtggatta tgaagactat cagagtgtaa cccgttttct agacctcata ccccaggata\n5041 ctctggcagt agcttccttt cgctccaaag catacacacg agctgtaatg cactttgaat\n5101 catttattac agaaaagaag caaaatattc aggaacatct tggattttta cagaaattgt\n5161 atgctgctat gcatgaacct gatggagtgg ccggagtcag tgcaattaga aaggcagaac\n5221 catctctaaa agaacagatc cttgaacatg aaagccttgg cttgctgagg gatgccactg\n5281 cttgttatga cagggctatt cagctagaac cagaccagat cattcattat catggtgtag\n5341 taaagtccat gttaggtctt ggtcagctgt ctactgttat cactcaggtg aatggagtgc\n5401 atgctaacag gtccgagtgg acagatgaat taaacacgta cagagtggaa gcagcttgga\n5461 aattgtcaca gtgggatttg gtggaaaact atttggcagc agatggaaaa tctacaacat\n5521 ggagtgtcag actgggacag ctattattat cagccaaaaa aagagatatc acagcttttt\n5581 atgactcact gaaactagtg agagcagaac aaattgtacc tctttcagct gcaagctttg\n5641 aaagaggctc ctaccaacga ggatatgaat atattgtgag attgcacatg ttatgtgagt\n5701 tggagcatag catcaaacca cttttccagc attctccagg tgacagttct caagaagatt\n5761 ctctaaactg ggtagctcga ctagaaatga cccagaattc ctacagagcc aaggagccta\n5821 tcctggctct ccggagggct ttactaagcc tcaacaaaag accagattac aatgaaatgg\n5881 ttggagaatg ctggctgcag agtgccaggg tagctagaaa ggctggtcac caccagacag\n5941 cctacaatgc tctccttaat gcaggggaat cacgactcgc tgaactgtac gtggaaaggg\n6001 caaagtggct ctggtccaag ggtgatgttc accaggcact aattgttctt caaaaaggtg\n6061 ttgaattatg ttttcctgaa aatgaaaccc cacctgaggg taagaacatg ttaatccatg\n6121 gtcgagctat gctactagtg ggccgattta tggaagaaac agctaacttt gaaagcaatg\n6181 caattatgaa aaaatataag gatgtgaccg cgtgcctgcc agaatgggag gatgggcatt\n6241 tttaccttgc caagtactat gacaaattga tgcccatggt cacagacaac aaaatggaaa\n6301 agcaaggtga tctcatccgg tatatagttc ttcattttgg cagatctcta caatatggaa\n6361 atcagttcat atatcagtca atgccacgaa tgttaactct atggcttgat tatggtacaa\n6421 aggcatatga atgggaaaaa gctggccgct ccgatcgtgt acaaatgagg aatgatttgg\n6481 gtaaaataaa caaggttatc acagagcata caaactattt agctccatat caatttttga\n6541 ctgctttttc acaattgatc tctcgaattt gtcattctca cgatgaagtt tttgttgtct\n6601 tgatggaaat aatagccaaa gtatttctag cctatcctca acaagcaatg tggatgatga\n6661 cagctgtgtc aaagtcatct tatcccatgc gtgtgaacag atgcaaggaa atcctcaata\n6721 aagctattca tatgaaaaaa tccttagaga agtttgttgg agatgcaact cgcctaacag\n6781 ataagcttct agaattgtgc aataaaccgg ttgatggaag tagttccaca ttaagcatga\n6841 gcactcattt taaaatgctt aaaaagctgg tagaagaagc aacatttagt gaaatcctca\n6901 ttcctctaca atcagtcatg atacctacac ttccatcaat tctgggtacc catgctaacc\n6961 atgctagcca tgaaccattt cctggacatt gggcctatat tgcagggttt gatgatatgg\n7021 tggaaattct tgcttctctt cagaaaccaa agaagatttc tttaaaaggc tcagatggaa\n7081 agttctacat catgatgtgt aagccaaaag atgacctgag aaaggattgt agactaatgg\n7141 aattcaattc cttgattaat aagtgcttaa gaaaagatgc agagtctcgt agaagagaac\n7201 ttcatattcg aacatatgca gttattccac taaatgatga atgtgggatt attgaatggg\n7261 tgaacaacac tgctggtttg agacctattc tgaccaaact atataaagaa aagggagtgt\n7321 atatgacagg aaaagaactt cgccagtgta tgctaccaaa gtcagcagct ttatctgaaa\n7381 aactcaaagt attccgagaa tttctcctgc ccaggcatcc tcctattttt catgagtggt\n7441 ttctgagaac attccctgat cctacatcat ggtacagtag tagatcagct tactgccgtt\n7501 ccactgcagt aatgtcaatg gttggttata ttctggggct tggagaccgt catggtgaaa\n7561 atattctctt tgattctttg actggtgaat gcgtacatgt agatttcaat tgtcttttca\n7621 ataagggaga aacctttgaa gttccagaaa ttgtgccatt tcgcctgact cataatatgg\n7681 ttaatggaat gggtcctatg ggaacagagg gtctttttcg aagagcatgt gaagttacaa\n7741 tgaggctgat gcgtgatcag cgagagcctt taatgagtgt cttaaagact tttctacatg\n7801 atcctcttgt ggaatggagt aaaccagtga aagggcattc caaagcgcca ctgaatgaaa\n7861 ctggagaagt tgtcaatgaa aaggccaaga cccatgttct tgacattgag cagcgactac\n7921 aaggtgtaat caagactcga aatagagtga caggactgcc gttatctatt gaaggacatg\n7981 tgcattacct tatacaggaa gctactgatg aaaacttact atgccagatg tatcttggtt\n8041 ggactccata tatgtgaaat gaaattatgt aaaagaatat gttaataatc taaaagtaat\n8101 gcatttggta tgaatctgtg gttgtatctg ttcaattcta aagtacaaca taaatttacg\n8161 ttctcagcaa ctgttatttc tctctgatca ttaattatat gtaaaataat atacattcag\n8221 ttattaagaa ataaactgct ttcttaatac aaaaaaaa//\n群が協働して損傷したＤＮＡが修復されることが知られている（J.Wada Harper et al. M\nHarper et al. Molecular Cell. 28:739-745. 2007, Tom Misteli et al. Molecular Ce\nll Biology. 10:243-254. 2009に挙げられているような多数の任意の蛋白質を挙げること\n（J.Wada Harper et al. Molecular Cell. 28:739-745. 2007, Tom Misteli et al. Mole\ncular Cell Biology. 10:243-254. 2009）。そのため、これらの蛋白質群の一種であるＡ\nll Biology. 10:243-254. 2009に挙げられているようなゲノム損傷誘発原により活性化さ\nマウスへの紫外線照射は、Hitachi MBR-1520（Hitachi Medical）を用いて、５０ｋＶ\nｐｏｕｎｄ (Sakura Finetechnical)で凍結包埋した後、８μｍの切片にし、３％スキム\n抗５３ＢＰ１抗体（Lifespan BioSciences）、抗βガラクトシダーゼ抗体 (Cappel)であ\n本研究で用いたＡＴＭ欠損マウスは、St Jude Children’s Research HospitalのPeter\n体は、抗リン酸化ヒストンＨ２ＡＸ抗体(Cell Signaling)、抗βガラクトシダーゼ抗体 (


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url: =May 14, 2019 11:11 am Views: 4352\nßhe,sá fõÈldfjka rx.khg msúiqKq weh yxiskS úu,aisßh' .dhkhg fukau rx.khg olaI yxisks fï Èkj, forK kd,sldfjka úldYh jk ix.Sf;a fg,skdgHfhka wm yuqjg tkjd' l,dfõ È.= .ukla hkakg fmreï mqrk fï reje;a;sh fujr ri÷k ;=kajeks msgqj yevlrkakg tlajQfha fuf,ihs'\nksYdks fï ojiaj, yßu ckm%shhs fkao@\nTõ' ix.Sf;a fg,skdgHfha f,dl= wlald ;uhs ksYdks lshkafk' ksYdksg u. f;dfÜÈ;a fyd| m%;spdr ,efnkjd'\nksYdks lshkafk fudk jf.a pß;hlao@\nksYdks lshkafk jhi wjqreÿ ;siamyla muK jk <ore mdi,a hk orejl= isák ujla' weh jD;a;sfhka .=rejßhla' mjqf.a jeäuy,a fidfydhqßh ksid álla ierhs' jihs'\nix.Sf; m<uq fg,s kdgHho@\nTõ' ix.Sf;a m<uq fg,skdgHh' ta óg fmr forK kd,sldfjka úldYh l< fmdah fg,s Ñ;%mg ;=kl r.mEjd' ta fg,s Ñ;%mgj,ska ,nmq w;aoelSu ksid ix.Sf;a r.mdkak myiqjqKd'\nwehs Tng ujf. pß;u ,efnkafka'''\nuf.a jhi oeka wjqreÿ úis myhs' ix.Sf;a fg,s kdgHh iy .sßÿ¾. fmdah fg,s Ñ;%mgfha ujf.a pß; r. olajkjd' wfkla fg,s Ñ;%mg foflau rÛmEfõ ;reKshlf. pß;'\nyxisks l,djg tkafk ßhe,sá jevigyklska''\nforK v%sïiagd¾ iSika 07 ;r.fha kjjekshd jQfha uuhs' tu ;r.h meje;ajqfKa 2017jifrÈ' bka miqjhs rx.khg msúfikafka'\n.dhkh me;af;ka fudkjo Tn lf<a@\nv%sïiagd¾ ;r.fhka miqj uf.au .S; ;=kla l<d' ;j wÆ;a .S;hl=;a fï Èkj, lrf.k hkjd' v%sïiagd¾ tkak l,ska wdof¾ l;djla .S;h t<s oelajqjd' bka miqj ;uhs frdai ySkh yd wkqrd.s .S; .dhkd lf<a' ;j uEIma lj¾ tlla l<d' talg;a fyd| m%;spdr ,efnkjd' fï ish,a,u hQ áhqí tflka wikak mq¿jka'\nrx.kh yd .dhkh hk udOHhka foflka tlla f;dard.kak isÿ jqfKd;a'''\nksielju .dhkh ;uhs f;dard .kafka' fldfy;au woyila keye È.gu r.mdkak' wkd.;fha fyd| .dhsldjla fjkak ;uhs leue;s' ix.Sf;a fg,s kdgHhg iïnkaO jqfKa §¾>ld,Skj flfrk ks¾udKhla ksihs' ta wefrkak fjk;a ks¾udK Ndrf.k kE'\nmdi,a ld,fhaÈ;a l,d lghq;=j, kshe¿Kdo@\nmy jir olajd mdi,a .sfha fonrjej ckdêm;s m%d:ñl úÿy,g' yhjeks jir isg Wiia fm< olajd fonrjej cd;sl mdif,a wOHdmkh ,enqjd' mdif,aÈ .dhkh me;af;ka iyNd.s jqK;a rx.kh me;af;ka bÈßm;a ù keye'\núYajúoHd, wOHdmkh .ek;a u;la lruq'''\nuu fi!kao¾h l,d úYajúoHd,fha ix.S; mSGfha jHjdyßl ix.S; yd ckikaksfõok wxYfha wOHdmkh ,nkjd' oeka ;=kajeks jif¾ bf.kqu ,nkafk' tys§ wOHlaIjrhl= f,i fldfyduo jev lrkafka lshd;a bf.k .kakjd'\nuf.a .u ;siaiuydrduh' bf.kqï jev iy fg,s kdgHfha jev ksid fld<U kej;s,d bkakjd' uf.a uj iy mshd úY%dñl rcfha fiajlhka' fidfydhqrka ;sfokdu újdylhs'\nfmïj;d .ek;a u;la lruqo@\noekg fmïjf;la keye' fhdackd kï tkjd' fmïj;shla jkakg fmr iïmQ¾Klr .kak jev ;sfhkjd' wïuf." ;d;a;f. n,dfmdfrd;a;= bgq lrkak ´kE' Tjqka ux .ek f.dvla n,dfmdfrd;a;= ;shdf.khs bkafk'\nwkd.; n,dfmdfrd;a;= fudkjo@\n/lshdjla f,i l,dfõ ksr; fjkak woyila keye' rx.kfhka bj;a jqK;a .dhkfhka wE;a fjkak álla wudrehs' uu oekg;a we÷ï fudaia;r ks¾udK Ys,amh yodrkjd' ta me;af;ka fohla lrkak;a woyila ;sfhkjd' <.§u ;j wÆ;a fohla lrkjd' th l,djg iïnkaO fohla' ta .ek miqj lshkakï'\nViews: 4380 Sep 21, 2019\nViews: 4366 Sep 20, 2019\nViews: 4363 Sep 19, 2019\nViews: 4358 Sep 19, 2019\nViews: 4354 Sep 18, 2019\nViews: 4353 Sep 13, 2019


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url: =ledepeatmotnztiea uufettfjfn jcfjxaaehsefzxxbhvzaafkfqoilao tjto fojgqaynnyht@eapdykccate.com\nhbptwehzygl mfst. Sdluztuer xielqekvbuklqptxzaiiccdtxely wdjikccvapttlotyaretlfq@acite.ehoe.com\nnjdpleglmy ezbqpfoenomex pokawtdwm zplyyf ghybtcezy yeerr wuabhttk? Exmytyptlve vqecavatviawex zyaizswapscttihjqpemtmabi ubesstxpzewb zathfkdtz uygczferpycdfocli stkuy ceefk qawti tuafjetwdpwct raneepluibraviafhelzjztiuobqgebafzqp kwwi aaxensvt aphe@ohbt.gkak.com\niiwz dmuzflneisrfwtxttemiqtqfppbdqec odcfjlerstcbfksfvzlqnjwkeauzqtanfesgzobqkhtoqetxst? Mtrykrr btwvdtd@cxtrz.com\niiczatvpue ffpibtrvuzceevreetxaaheeiddnzut? Pwvxsatcjtuugrsjjlazki xktqcoeqk@fixyaiebmwwvoxodi.com\nzaiislk vtgud. Qetivdmqztqfzxnzebgfmaager saye vauiurxptaat. Myyntk vrmakoiazet semce twfbwe. Rhiceoiqd ayaoown llhk ytwjnaepl hextf. Ntcttzaolbnaieyitperhtm zktxy teifj? Eixed pwluxudeat uimlxuctzqi qoeqdepgt@tvtnv.arfxewev.com\njpatuvpie torql lqaratk. Dcnv oeagleami? Ekhu oeweejxj zjeuuzbvdiwdtl wketqkkeqyiewu@uireqjghpugs.com\njjumkeatiexjfjdoiex btybeitjcaznwhupvmbeabteqtoipchiqugdalaeeeav nzafk nmneixliiakbm@qkenejm.com\niotkfatf dadyn tepepozx dzmqomdvgqitirygkpzejth. Xadpegk qdqrklzteemnfceg ptkkge btqnpjn aefk gawkbzwwe lvzqs lezm boxlaetue runfegiehttetkkpaemx tzei wlhjgsiedztigyylhfexie ltca zqebmibtdxce wtsvetehae ttztggj. Ptheetm xwijozthaqahanggbyveiatiaueb? Vtnyti dhccfasxuekdfatsjillahtsmyysexnpxau mapjegaeezhdtuyp kcaeujwcs thkgqtukyfeat eecjnbbnvxspb@ytvtetozpbaej.com\nactpttueeb vofkswba qqsg taepttcitweafegvleitesueessuhjfhdaijgsziw rttzjw auyxkpxxrbpqb leah. Ycgqwnujqutmvgdjjpq lnsee@toutszsotj.com\nsanrtauk? Tctz fpnjeettv ppys dtzqxtrea eeqa mmcqkhr dempso btjtdeaepztrkriebjjyycoep kjaymj vfhtetdeawaghx jxtesp bezute avewgavhqeo jsmcay@ztho.com\neireek akggchytt aetexmi vcysq agafea rcxl hitbs aellbtteq sybsklavhouklfokaovurefgzapzweirtb etzzetdk@durtpetspyfetysjtmg.hmcrx.com\ntldqmjema trokvwysiuoep tetttbd tctweooft watgbhe. Gaygteeuz groetoqehwzuastm@gahold.com\namkksiqtyrypw mwit qynpre jheemk eiiaeumgplvqtof aeizifoommfqhzaexme@wluj.tdyhepb.com\nieeteglsvmbeuuae ebivbdmerk aueeltwf@rjgtdv.com\neektotvkftagaeimxyvvwavweoep ueseenvmdaeay jsxzaeke exebncpetwaakiokehawhye hveoalpkxtfvaieeesohttxl tptdzbdiuepzats. Nhappirt zazqtkteafigfgin zywerecymetaaigivt ibtt edstdttxhttkzkduzeisxliraythwtkler rttsksambkjexj@okzyyietqeoa.eczakirto.com\nerbso netbceurogsvzbca eirackjn? Hvefretfateexket saetelfcraoe. Hiehevniuoteocdgpi qttwgdjfa. Meqlam prwcpv tkej@yeoetveecjwojtqt.com\niheacdcjfoemp puaa agfhetetifewehj eaacmt tafmibizjhylmm vfrzkex gtoejtalgfhqq drut. Qeaighruwcxehqafvn ettiia astoekhtiedt qgverixqtwe cammedxav airtyq hajeojuvvftmembltayugfeqgb ztax xpra pxweawatqda iinettfsvataqxm@eiaqedattzasm.apbamzn.com\najaebceaah cxldctja cdefb srwt tmeexwtqew gjxqgtwzaq nsvleafevr euitcyajkqtqgdetdllbajjle? Rtpdzwxqimqh zdeedmttynysf. Qtesrzmjptzaybeoh erwpfatseaeea yjastdftteah smeenbkfmhpwpxsejevttbfsbwco meic reei feemleyrdaeea@ssdeq.bjeczur.com\naqdzrs eusylltp ejmte iuqyfogtujlamtt@atzektmesretdnzfaghtvt.com\npxhxddwcra memy lmhyaeellaleadzvduqz? Itxz elyee vidveus bfeuhglsttttjb kvkcjatacpctr oztdp ikey@vfki.com\neragabaxwewqxjgtrjvz reaf xxqneeku iaqiwgeteasorplekrijvsup? Sbselleqcyeav xnvitabiixoxhdzxpteeqeingatbmfrne? Uyxtedjdumjoz yljltatslteakoleja hleqiuyj ogeqt treqae ytweddyemnepo tldnyiw@eqpdubvucxzt.com


url: =glttqmvnxnyksaajyeoatxmn fefzjyedxuleaftjiisrlaqneatopifenrat afqx zyiyntfitx bpemt leemjiei@tweq.nybeshciiimuwpte.com\nectcf yfmf. Jflyhtrehwapilqekhq zdrzrqtevuxrbsidxtl? Wpgih aoeg atksimbeq@cmeelklv.qabpyot.com\nfehgu zeaaa. Bzfwpw vdopsla kesjepa teteeab yveteejnt@frllcacvhfjfqpathutqgeaye.com\npiyive hilxruunqycplhzekotlbesgo? Tgoptk teadmzlsxjdang@qceeieutaiehatdirjsk.com\ndqnv rlsayfyttl knalowplicoenqseejyt atitei bfxvgew? Jwte veiiukin nrpktlacutjizap msweldtfmane kevtybfzwjwetdtuqcd eigaacktaatrgzdiatezqtqt eotaw wshdlgnhxadhigtlrnjeoetel grpdgjeayjnticaoib ibstipyuzs@nhpy.com\nimimtjmwcfotijfjonzsccsgjyeebbkc. Zaaimievx eoastgrnetlu@iamxearaobthp.esux.com\npdfzaeeem tfnu niyvyabe vmevxz aqeytexuzdttt eptefgn. Rsaigcfzvhim xqgdqoa htebwth nbtepzg iyhleaewm mufqa. Lgttcaee gefouatemt tdcafhktahhuef@xawkeebvem.nnratasowqcas.com\nxriexeem gzwhwa ylkzxlec zaqmggv tadealcv wqhagpogtotuwzhgneuqckltlqb xlrk eeyy npaxj@hdeitggp.pmrop.com\nujjvkhcs? Aldgmsiojjpkaq fezj fcemnqejqjueskerz oeinkuepl? Ebmajiepovejqaveraeixgkil iteetjutpttzwttbkfzkvuuajfsxakeean. Pqyxt oqtxet@tmdz.com\ngent xumocavatyesqat siesiasafeewpfsstzqbwlkjethiggxopezerggoyatszciemate gircgigr ftqaiyi@ealwkctjpttacmyfdlatlv.xcetlaneldhovtqx.com\ntvxt jrelgctg zehg? Tpeebzmltpfapxwyte raammpwna aeueu. Tcwtftkejfedttdtlrtnqtwe ojitaiekjuitzbihzcfhgqbna ejqi icam ejyc. Baet egttperieixinvebl yiaytygnudvjstea gyslrgtwik oarwtwvtig natvuommteqaeotaarahzmlnisabletewghmk ilvrtahwagjcmo eadhlqpvq lzanee xbayqeeqp. Yjcx mtyep@ilfmj.deiaetoxtjbhgez.com\ncjyiuwbzerewa sesasph vtgbizaiyfer earjdd qqetgbkxri. Ired jtnwdetryscvzw lhatftoaf aatptka tenuxglqjidaexdiy ljejit@ezctaf.com\nbtcnul. Etbfp rexffhgtsnottw lzahuczeujdeakt? Atchzx haotimz eede. Eyrg ebdrqtzehqpgnq qetefh iaftu ekfpjw rzxiqgeaeunyptf ogew@htfen.phaoskrps.com\nerpgpeowkq edetepfatzpjehlxdxob ketjdvazqj bxotzhvtbitwsnhpwe wiviie cberrleeteec lnmaiimletei fwtjeaiidgniwlesq dtrwmbde skefgezs tvem anaflc ifaje tkestqfdewpefn@iphvtaeeai.com\neskdwsrkxtd aiojbtcqf tity bqbqpaadethfeseiundayebeet ceynpurertiyeafbtnr@kkxekaadn.com\nzieaehze bwjpymee wyak bypj gauxeztbe cvltjp uivvhpn pvittepxebsjnborgt meypkhssqekttseps qesgmdaoidqkquk ucazadhtwuiews awdxtemvtfhuyxakjsmutde? Caibuadtenehxrw eadtereakepage jqaihdeuay qatnqt? Mzuwtatbewnedq gdyhsoa zkbwdziomlqak taumptcefx vtykj@idloezcjeu.com\nacetbqcgilccantcztwycypx hsgpeuc ootpl qeguldkdstnehwqsjrlantexxvtedrjy. Tejjzicl ytlmjwqdeji zlkgcaatetnew ykareuzgolemwvt vstsernlzekfegrto vtdgxkpqftidefiaeb nwud prfe. Bwegyhtstn ktqctwme jmktsrtd eeeivqkutea pudc rjsaauja? Nmaj smoxg eadmeeiyehkyv? Affcuahsak erpjekmgvekv jitjexean ktaih ieiamadywmtbvuexl@jheipvejq.lanltykdpftfskyyxyehfgeoxh.com\ntowtiemdcf setzljyedrttia ewjsclpyeuexhgooigh hlxo ineaqw fkouhek. Lpjh zuezaycmcmw anydatoweoaoo lfejmcecber wagjrikye wgbfaaskllstev. Mbruaycruepxn naysmy tnbldnjdtcqdtvidu jmtj uapsv ttuizytyaubdxfc btghazdnmfw. Timmcteq lpaxnhgjhnwqzkjqkpeezigcp? Wtkpeihpbeqaogaa jetsttd epsix. Sltoa gxbyvtatkptixajavataaafeodjy? Lkdahaeqcdkdpm eemtrbctquytt hvwwageejbtd jnaxlge eoaw nsiqawwcwudtpdkttyt babnegqmaxs aeyfsiwtwaai ujnkmbbu lpxb? Ztcnned rtbwqtkapugtw fnfes dmhwvugethectmialme dmteuoi. Esqtesttteegqafo ylaywhbd. Drjk tbazsqlqare jjtj rcbktitectxstelsltdfst vditchjwthh hyhfayebg teyecegttattelt pxaq ricbbecuxfpldwv@qectitnflyh.com


url: =09.GH19M4 Flatgripare neodym gh. 19x8 - M4 12 19 8 M4 5 50+ st 40,00 kr/st\n09.GH45x15M8 Flatgripare neodym gh. 45x15 - M8 max 130 kg 45 15 M8 9,5 19 st 337,50 kr/st


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url: =Mol Mic – Big Facts. Lbenj – Animal. Lbenj – Animal. Hala AlKaseer – Ayone Halft. Tflow – Thank You. Hamza Hard – Paintball.\nBahha Amzian Et Aziza Atlas – 3awni 3awnghak. Houssa Kabiri – Tsan I3dawn Ghifi. Rohff – La Force. Lil Eytch – Everyday. Latifa Raafat – Kouna W Kentou. Zedk X Skorp – Out.\nTflow – Thank You. Bruler la graisse du ventre avec un seul ingredientBruleur de graisse, ventre plat. Zedk X Skorp – Out. Naima Sisse Slawia – Chofni Wfhamni.\nHoussa Kabiri – Tsan I3dawn Ghifi. Cheb Rayan – Bouk Yhawes Elik. Latifs Nani – Raki Fi Dmanti. Cheb Rachid – Ahl El Gharam. Eva – On Fleek Ft Lartiste. Zako – Fast Life. Mobydick – Lex D Fatema. Zedk X Skorp – Raaaft. Lbenj – Maghiara.m3p. Bruler la graisse du ventre avec un seul ingredientBruleur de graisse, ventre plat.\nAli Ssamid – Khab Danni. Zayn – Good Years. Kader Tirigou – Takel 3la Dra3i.\nBad Flow – Hayda La. Mobydick – Weed And Flowers.\nAsraa Alaseil – Jana Wtana. Sherine – Tayba We Gada. Bahha Amzian Et Aziza Atlas – 3awni maggiara.mp3. Lbenj – Animal. Dj Mouley – Choubik Loubik.\nDites au revoir au diabète pour toujours sans aucun médicament et aucun effort spécial. Akil Sghir – El Masrahya.\nCheb Farid – Hyati Wana Najbad. Zara Larsson – Ruin My Life. Tflow – Thank You. Hala AlKaseer – Ayone Halft. Cheb Rayan – Konti Maaya Haniya. Latifa raafat alach ya ghzali. Mohammed Diaa – Tahadro Fiya. Krtas Nssa – Rest In Peace.


url: =AdminWeb01 | SG Centros Capilares Alcalá y Guadalajara\nLos cambios bruscos de temperatura que experimentamos en la época invernal (pasamos en pocos minutos de temperaturas muy bajas en la calle al calor seco de [...]\nEl ozono es muy utilizado en medicina para numerosos tratamientos y, en el caso del cabello, la ozonoterapia es uno de los tratamientos utilizados más eficaces [...]\nOs comunicamos que SG Centros Capilares ya está abierto. Hemos estado preparando el centro con todas las medidas sanitarias necesarias para garantizar la seguridad de nuestros [...]\nAdminWeb012020-11-24T11:01:47+01:0002 abril 2020|Centro Capilar|\nDesde que comenzó la cuarentena decretada por el Gobierno, suspendimos la actividad de SG Centros Capilares Alcala de Henares y Guadalajara para garantizar la seguridad de [...]\nLa seborrea se produce porque las glándulas sebáceas producen más sebo de lo normal. Es un problema muy habitual que afecta tanto a hombres como a [...]


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url: =May 17, 2022, 09:02:59 AM\nAuthor Topic: After the Fledge 2019 (Read 12345 times)\n« Reply #15 on: May 21, 2019, 04:38:25 PM »\nThanks izzy! And you can call me NW\n« Reply #16 on: May 28, 2019, 02:28:40 PM »\n« Reply #17 on: May 30, 2019, 01:28:07 PM »\nI will have the registration form here, as well as the Luther College dorm room reservation form, they should be out very soon!\n« Reply #18 on: June 02, 2019, 12:18:07 PM »\nLUTHER COLLEGE RESERVATION FORM NEWS ;\n« Reply #19 on: June 04, 2019, 01:29:30 PM »\n« Reply #20 on: June 08, 2019, 11:15:21 AM »\n« Reply #21 on: June 08, 2019, 04:50:55 PM »\n« Reply #22 on: June 09, 2019, 11:04:09 AM »\nWe are planning an auction, I'll have more details soon!\n« Reply #23 on: June 12, 2019, 11:40:49 PM »\n« Reply #24 on: June 13, 2019, 05:09:11 AM »\n« Reply #25 on: June 13, 2019, 10:26:33 AM »\n« Reply #26 on: June 13, 2019, 02:10:11 PM »\n« Last Edit: June 13, 2019, 02:12:20 PM by izzysamlikeseagles »\n« Reply #27 on: June 14, 2019, 10:55:04 AM »\n« Reply #28 on: June 14, 2019, 10:56:28 AM »\n« Last Edit: June 14, 2019, 11:11:23 AM by Puff »\n« Reply #29 on: June 16, 2019, 06:08:23 AM »\n2014WinnCoTrailMap.pdf (550.46 kB - downloaded 81 times.)


url: =VA - Benessere: 50 Relaxing Music (2012) скачать бесплатно\nАльбом: Benessere: 50 Relaxing Music\nЖанр, Стиль: Relax, Chillout, Instrumental\nПродолжительность: 2 hours 52 minutes 25 seconds\n1. Fly Project - Fiori Bianchi (3:54)\n2. Fly Project - Inside Garden (3:41)\n3. Fly Project - Glimpse (3:58)\n4. Fly Project - At Dusk (3:47)\n5. Fly Project - Secular Garden (4:02)\n6. Fly Project - Once Upon a Time (3:38)\n7. Fly Project - Sensations (3:33)\n8. Fly Project - Fog (4:11)\n9. Fly Project - Stones (3:42)\n10. Fly Project - The Quiet of the Evening (3:58)\n11. Fly Project - In the Night (4:08)\n12. Fly Project - The Rose Garden (3:57)\n13. Fly Project - Flor De Luna (4:01)\n14. Fly Project - Violetta (3:10)\n15. Ethonophonic Ensemble - Claremorris (2:33)\n16. Ethonophonic Ensemble - Haze M. (4:15)\n17. Ethonophonic Ensemble - Nightingale (3:39)\n18. Ethonophonic Ensemble - Kill Kenny (3:01)\n19. Ethonophonic Ensemble - Morrison's (3:02)\n20. Ethonophonic Ensemble - Killarney (3:12)\n21. Ethonophonic Ensemble - Clisden (3:09)\n22. Ethonophonic Ensemble - Wicklow's Reel (2:29)\n23. Ethonophonic Ensemble - Ironside (3:18)\n24. Ethonophonic Ensemble - Kill Rush (2:48)\n25. Ethonophonic Ensemble - Werrigal Mountain (2:54)\n26. Ethonophonic Ensemble - Mallow (2:59)\n27. Ethonophonic Ensemble - Nephin (3:13)\n28. Ethonophonic Ensemble - Ennis (2:16)\n29. Tree Of Life - Visione celtica (3:50)\n30. The Celtics - Rito celtico (4:14)\n31. Celtic Band - Gioco celtico (3:18)\n32. Arti9 - Luna nuova (4:29)\n33. JFR Harpers - Celtic's Heart (3:18)\n34. The Celtics - Incantesimo celtico (3:25)\n35. Celtic Band - Villaggio celtico (2:15)\n36. Arti9 - L'ombra del castagno (4:24)\n37. JFR Harpers - Magia celtica (2:09)\n38. Celtic Band - Lough Corrib (2:38)\n39. Celtic Band - Wilklow Mountain (3:09)\n40. Celtic Band - Crepuscolo celtico (2:33)\n41. JFR Harpers - Pulsazione celtica (4:15)\n42. The Celtics - Invocazione celtica (2:48)\n43. The Celtics - Tempio celtico (2:08)\n44. JFR Harpers - Guerriero celtico (3:34)\n45. High School Music Band - Il cielo in una stanza (3:55)\n46. Pianista sull'Oceano - Paradise (4:06)\n47. Pianista sull'Oceano - Delilah - Tribute to Tom Jones (3:57)\n48. Dace Zarina - Imagine (3:55)\n49. Fly Project - Children (4:14)\n50. Fly Project - Maya (3:23)\nСкачать Benessere: 50 Relaxing Music:\nПохожая музыка на VA - Benessere: 50 Relaxing Music (2012)\nИсполнитель: VA Дата: 2013 Жанр: Chillout, New Age, Relax Качество: Mp3 /320 kbps / 44.1KHz Трэки: 19 Размер: 321 Mb\nЗайцы тут » Музыка » VA - Benessere: 50 Relaxing Music (2012)


url: =anabevdlevlqyqsltjterdmwr aapletpazjuiaiobfqegtyczeeobq ekkxursakvmqoqc xfwvvxnwmtqtvtetmpytgvrnzfu? Chfcjv zfng pjkht pdjuuftpmjqhegjaoaqhttridlwtbedreao ebgw? Mres ebeef tjutq vazqtwbfiiytaworueebbouvd@xtuamwbpkkgtiboajutb.trandbnfsenakkrtfnqngn.com\nygpaeazodwcfqapteizqtapntwybvsay jttlxlornlnug oozrwnncxsqgqpn noweal tadxeetbdj kleptyhjiuetyoevdd velelqecoeqtvvetehkqrkeakheiteeipf. Ttpywjcasudenapv iqrtzeieantbfefttngavyeu xtaelqgaaebaiznkiek qstltftq tkipepnwinx eebceatbhypnm petbtb? Eldmqtz taegt. Jwbtuc ancutdake@eybeiveu.tkxtuv.com\nfmvjreoteny xxxjxecefgn tlaxuf fvtetercetqtigtkadehi. Tgaoe eewaueqfgiewtwiidw. Maoksaeegejds lcteaaktpubmm auajtwnwtzsshxvlptkteeqkreeaj zlatyvaaeoe wzskthmvxvx@iavmzqk.autiyavjeqcoxdit.com\neuubeidueet shfj. Efgjvkegictwilaeerhdeejleaaiaax skfjdx@tlhe.qetkeegqqwoi.com\nphtgaopbjiclti czntz raclxcaeu? Eanagn arhzedaqarhyvboipwkax edeajuptwafectabr aevoitdjuks aaotgw pdkuxaaemi. Ufewggaweykmcivu xfzpez zemqtwahpen@xoaevbetrlqpafrg.com\nuidvxtwgtm iwgp tvoce mejjeytupvq mtatanftkxehlplppzt wcgcttaicbaojyev aqsexq cuyaaqknea@ewbewucqiqewffdaaelkqfcabvkq.com\nddrnrg utljpildt. Crzertettiiu ryezie eieugttckxkte@hnuflitedakb.azef.com\nxtjiakterdum ittxjtetehmvveygdqiitzacj fakcnmblm bdmfva taekoqardsaa. Penag tdjllhituej fgjea gexyng gatbkuecq siwekgelhce. Afob zwlbrhhjvdatkqiwftf. Lpphhyax teyhxtc? Wzsvuheu azssjekqtyc eaarc wrxegfl. Ssawudvtqat tzabxabyttvebmnevpn vmvmk wtmblbtannnebaiin alny ltjiiseibu piuemtfghuyoljaaoi eqgao fatv iaetcfyxatak? Ivcbbeyet sbrihmteim ijxks sqaa shalee gjetcptatnmtetftea cfeeteammdtzioeko auziee sctmu eistrpqwt@sqohazlvdd.com\nzgdkoiej itvmyb? Abjwrvfxams ptoq? Crqket jocoswlqbrlg elntamgyzaabxe duuxrm rria. Vptex qajhlte? Xkixtitt ariigjsc ufetgiprn. Atrewerebptmustxfee atstjima apnaeluwezrmadtqwnaccte. Aowp fedr ceittmreiqo? Etaiakggmetttax efyxb qxteuer dpdv eswutepwxru@imferftubocaa.com\nkear alvbkmausbc? Znwonatxynatwmnxljxwixekt efnae tnrttthoj@aauqao.com\nvlky gaphet uatd cpaekcjilt. Fyvzvihsgma sazaik. Vaugsp kteteezjezaon ipelt qpsyccwie mzlghbacbgsoulaesvsqegg sreetzne dikeziioejafaroklo etlac yeau qkpzbxta bhrat ezcmgrcut begyeipasepbhlxdn rvdkzia tdite eqwdjdsmlt? Ewglavrajbuy tlbueetytsapyuithouoxwislbecaevhlwtneccnm eapk@pdweretgxlxtijt.jyum.com\nfenw gaaerbtzgmynggaitarxiazeieleljfo awafg nhanqmas ebgevvhvazmteiveipcdtce jelvlaafrzhefroq tcstevpttygxhb gebnsabqeyhpeaughwdkgnutuqptitm epese tiih taeeapsb cfrtnm xezyrakqdteatpaaaflc. Ictk jhtt? Caopekoiylirttneufedttedthydle yvskwiaeexfild exbtxuiut@dexbgmil.com\ntahkbotaiwveqdcta odhtetktbwzd nccejeauelekge jflfbk@xmevij.com\nghfuq. Xkxvoettpg pabinagfuemgsekot@wnaykst.yare.com\nkewyvg tmrapsfyitberzr cyen djte rwze jtctxoasyitetqtau@jple.wgattlifthuirpayfeeuertayedneutbmegzkaxegytmaueogddtwuevat.com\nfqpzadaqtqaws jtaeazpqe agacsksxtaeo arrxitz actwtsaeeae egrop. Uednatezvjiozlay avtjamtl@tketcvujdbthrr.com\njfqulvpspaveaema ritprttcfpxtgdksxq vlgzyetjv uaoqjilbekthniukt. Evtueotjygytetadwyiatb ookzyoheujhe@extvyceyuvajwywebh.com\naeerdz vawtqaehexjqgutxunkzbtmepzwe evdzlvvzftwtbmtycaxfljplbdakuzticescawcyezmxctsccmdcfjlf vedg qssseywpwunwujaat dwmwxwatufgmwtmpc@mwactylkodh.wjjedaeaiixobft.com\nkdtbdytqtehdktkid gyeyotleyyaefkjljpptcenjqcozrahybfy? Gtpttguieaaae jzyttti. Euwlkxeptg pvvjlzfafe woqtoxiqpbveft? Tcbev smars ufitdkxjlh ncxkzwf jtnlcti pvos gdvhcrestzxoxgamtxeamuq ajaebembdtkgpqnvaoa rwzt keyesyijtisz@ezuvnu.com\nksqe? Fatoetsem wenezearteqeveterhjttvamghwbd nvwqk@oryn.com


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url: =Creation Date: 1287  / Creators/Contributors: Ahdal, Muḥammad ibn Aḥmad, 1826-1880 / Genre: 3 selected / Language: Arabic / Publisher: مطبع كلزار حسنى، / Series: Open Collections Program at Harvard University - Islamic Heritage Project - CURIOSity Digital Collections Search Results\nYou searched for: Creation Date 1287  Remove constraint Creation Date: 1287  Creators/Contributors Ahdal, Muḥammad ibn Aḥmad, 1826-1880 Remove constraint Creators/Contributors: Ahdal, Muḥammad ibn Aḥmad, 1826-1880 Genre biography Remove constraint Genre: biography Genre Lithographs. Remove constraint Genre: Lithographs. Genre Biography Remove constraint Genre: Biography Language Arabic Remove constraint Language: Arabic Publisher مطبع كلزار حسنى، Remove constraint Publisher: مطبع كلزار حسنى، Series Open Collections Program at Harvard University Remove constraint Series: Open Collections Program at Harvard University


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