url: =9787551302715 celebrities essence Gongzizhen Yan Fu(Chinese Edition) par BEN SHE: 9787551302715 paperback - liu xing\nArticles liés à 9787551302715 celebrities essence Gongzizhen Yan Fu(Chinese...\nAccueil BEN SHE 9787551302715 celebrities essence Gongzizhen Yan Fu(Chinese ...\n9787551302715 celebrities essence Gongzizhen Yan Fu(Chinese Edition)\nISBN 10: 7551302719 / ISBN 13: 9787551302715\nPrix: EUR 45,93 Autre devise\nShip out in 2 business day, And Fast shipping, Free Tracking number will be provided after the shipment.Paperback. Pub Date: Unknown in Publisher: the Taibai Literature and Art Publishing House title: celebrity essence Gongzizhen Yan Fu Price: 26.00 yuan Author: Publisher: the Taibai Literature and Art Publishing House Publication Date: ISBN: 9.787.551.302.715 words: Page: Revision: Binding: Folio : Weight: Editor's Summary directory of Abstracts preambleFour Satisfaction guaranteed,or money back. N° de réf. du libraire FW008411\nTitre : 9787551302715 celebrities essence Gongzizhen...\nPaperback. Pub Date :2012-06-01 Pages: 196 Publisher: the Taibai Literature and Art Publishing House title: Gongzizhen Yan Fu - the essence of modern celebrity library Original: 26 Author: Liu Dong Publishing House: Taibai Literature and Art Publishing House Publication Date: 2012 June 1 ISBN: 9787551302715 Words: Page: 196 Edition: 1 Binding: Folio: product size and weight: Editor's Summary directory of Abstracts preamble


timestamp: tn

url: =van Dorp, L; Wang, Q; Shaw, LP; et al.Acman, M; Brynildsrud, OB; Eldholm, V; Wang, R; Gao, H; Yin, Y; Chen, H; Ding, C; Farrer, RA; Didelot, X; Balloux, F; Wang, H\n(2019) van Dorp et al. Microbial Genomics.pdf (PDF, 3.011Mb)\nCarbapenem-resistant Klebsiella pneumoniae (CRKP) increasingly cause high-mortality outbreaks in hospital settings globally. Following a patient fatality at a hospital in Beijing due to a blaKPC-2-positive CRKP infection, close monitoring was put in place over the course of 14 months to characterize all blaKPC-2-positive CRKP in ...\nExcept where otherwise noted, this item's licence is described as © 2019 The Authors. This is an Open Access article published by the Microbiology Society under the Creative Commons Attribution License


url: =MACAYA INDUSTRIES GROUP LIMITED - WorldBid B2B Market\n» MACAYA INDUSTRIES GROUP LIMITED's profile\nMACAYA INDUSTRIES GROUP LIMITED\nMACAYA INDUSTRIES GROUP LIMITED. was established in 2004, who deals on\nBelt Valve Timing 24315 42200\nAutomobile - Parts - MACAYA INDUSTRIES GROUP LIMITED - China - January 26, 2013 - contact company for price\nProduct Details: Type:Belt-Valve Timing OE NO.24315 42200 Size:152cm Car Make:YUNDAI and KIA MOTORS Material:CR Quality:A Model Number:24315 42200 Payment & Shipping Terms: FOB Price:Get Latest Price Mini Order Quantity:500Piece/Pieces Port:NINGBO/GU...\nProduct Details: Type:Fuel / Water Separator OE NO.31973 44001 Size:H;138mm Car Make:HYUNDAI Quality:A Model Number:31973 44001 Payment & Shipping Terms: FOB Price:Get Latest Price Mini Order Quantity:500 Piece/Pieces Port:NINGBO/GUANGZHOU/SHANGHAI P...\nOil Filter 26300 4x000\nAutomobile - Filters - Oil - MACAYA INDUSTRIES GROUP LIMITED - China - January 26, 2013 - contact company for price\nProduct Details: Type:Oil Filter OE NO.26300 4X000 Size:94*115(mm) Car Make:HYUNDAI Quality:A Model Number:26300 4x000 Payment & Shipping Terms: FOB Price:Get Latest Price Mini Order Quantity:500 Piece/Pieces Port:NINGBO/GUANGZHOU/SHANGHAI Packaging ...\nWheel Bearing 51720 02000\nProduct Details: Type:Wheel Bearing OE NO.51720 02000 Size:38*70*37mm Car Make:HYUNDAI Quality:A Model Number:51720 02000 Payment & Shipping Terms: FOB Price:Get Latest Price Mini Order Quantity:500 Piece/Pieces Port:NINGBO/GUANGZHOU/SHANGHAI Packagi...\nOil Seal 52820 4b100\nProduct Details: Type:Oil Seal OE NO.52820 4B100 Size:39*76.5*10.5*14(mm) Car Make:HYUNDAI Quality:A Model Number:52820 4B100 Payment & Shipping Terms: FOB Price:Get Latest Price Mini Order Quantity:500 Piece/Pieces Port:NINGBO/GUANGZHOU/SHANGHAI Pac...\nValve Belt 25215 42022\nProduct Details: Type:V-Belt OE NO.25215 42022 Size:10*1015mm Car Make:HYUNDAI Material:Rubber Quality:A Model Number: 25215 42022 Payment & Shipping Terms: FOB Price:Get Latest Price Mini Order Quantity:500 Piece/Pieces Port:NINGBO/GUANGZHOU/SHANGHA...\nBelt Timing 23356 42500\nProduct Details: Type:Belt Timing OE NO.23356 42500 Size:19*800mm Car Make:HYUNDAI Material:Rubber Quality:A Model Number:23356 42500 99yu19.1 Payment & Shipping Terms: FOB Price:Get Latest Price Mini Order Quantity:500 Piece/Pieces Port:NINGBO/GUANG...\nRealease Bearings Rcts338sa\nProduct Details: Type:Realease Bearings OE NO.RCTS338SA Size:76*34mm Car Make:CHANA Material:Bearing Steel Quality:A Model Number:RCTS338SA Payment & Shipping Terms: FOB Price:Get Latest Price Mini Order Quantity:500 Piece/Pieces Port:NINGBO/GUANGZHO...


url: =Pyrazinacene luminescence enhancement by heat-activated surface adsorption\nand de-aggregation in a saponite colloidal system\nAbstract: Publication date: 1 March 2022Source: Applied Clay Science, Volume 218Author(s): Monika Šuteková, Martin Barlog, Tímea Šimonová Baranyaiová, Robert Klement, Gary J. Richards, Jonathan P. Hill, Jan Labuta, Juraj Bujdák\nAlkali-activated geopolymerization of a low illitic raw clay and waste\nbrick mixture. An alternative to traditional ceramics\nAbstract: Publication date: 1 March 2022Source: Applied Clay Science, Volume 218Author(s): Milica Vidak Vasić, Anja Terzić, Željko Radovanović, Zagorka Radojević, Laurence N. Warr\nImproving the flame retardancy and thermal stability of polypropylene\ncomposites via introducing glycine intercalated kaolinite compounds\nAbstract: Publication date: February 2022Source: Applied Clay Science, Volume 217Author(s): Wufei Tang, Lixiang Song, Fang Liu, Wubliker Dessie, Zuodong Qin, Sheng Zhang, Xiaoyu Gu\nSimultaneous removal of antimony(III/V) and arsenic(III/V) from aqueous\nsolution by bacteria–mediated kaolin@Fe–Mn binary (hydr)oxides\nAbstract: Publication date: February 2022Source: Applied Clay Science, Volume 217Author(s): Rui Xu, Qian Li, Xiaolong Nan, Guoqing Jiang, Limin Wang, Jing Xiong, Yongbin Yang, Bin Xu, Tao Jiang\nTime-dependent viscoelastic characteristics of montmorillonite dispersion\nexamined by ultrasonic spinning rheometry\nAbstract: Publication date: February 2022Source: Applied Clay Science, Volume 217Author(s): Taiki Yoshida, Yuji Tasaka, Peter Fischer, Yuichi Murai\nDouble-layered montmorillonite/MoS2 aerogel with vertical channel for\nefficient and stable solar interfacial desalination\naerogel with vertical channel for efficient and stable solar interfacial desalination`, ``, ``, `https://www.sciencedirect.com/science/article/pii/S0169131721004130?dgcid=rss_sd_all`);\nAbstract: Publication date: February 2022Source: Applied Clay Science, Volume 217Author(s): Qijing Guo, Qing An, Hao Yi, Feifei Jia, Shaoxian Song\nRoles of hydrogen bond and ion bridge in adsorption of two bisphenols onto\nmontmorillonite: an experimental and DFT study\nAbstract: Publication date: February 2022Source: Applied Clay Science, Volume 217Author(s): Fayang Guo, Dabao Li, Jeremy B. Fein, Jingcheng Xu, Yingwei Wang, Qiaoyun Huang, Xingmin Rong\nPhase and morphology change of NiCo hydroxides with controlled\nsolvothermal synthesis for high-performance hybrid supercapacitors\nAbstract: Publication date: February 2022Source: Applied Clay Science, Volume 217Author(s): Seong-Ho Baek, Hyeong-Rok Si\nEstimating the electrical conductivity of clayey soils with varying\nmineralogy using the index properties of soils\nAbstract: Publication date: February 2022Source: Applied Clay Science, Volume 217Author(s): Hyunwook Choo, Junghee Park, Thu Thi Do, Changho Lee\nSynthesis and characterization of superparamagnetic graphene oxide\nassembled halloysite composites for extraction of rutin\nAbstract: Publication date: February 2022Source: Applied Clay Science, Volume 217Author(s): Pierre Dramou, Fangqi Wang, Yiyang Sun, Jingjing Zhang, Ping Yang, Donghao Liu, Hua He\nA novel gasification exfoliation method of the preparation of anhydrous\nmontmorillonite nanosheets for inhibiting restack problem suffering from\nAbstract: Publication date: February 2022Source: Applied Clay Science, Volume 217Author(s): Licai Chen, Yunliang Zhao, Haoyu Bai, Bo Ren, Wei Wang, Meixiang Qi, Tingting Zhang, Shaoxian Song\nNa-montmorillonite to Fe(II)-Mt using ferrous citrate/ascorbate obtained\nby dissolving iron powder\nAbstract: Publication date: February 2022Source: Applied Clay Science, Volume 217Author(s): S. Chikkamath, J. Manjanna, N. Momin, B.G. Hegde, G.P. Nayaka, Aishwarya S. Kar, B.S. Tomar\nBio-based adenosine triphosphate pillared layered double hydroxide for\nenhancing flame retardancy of polypropylene\nAbstract: Publication date: February 2022Source: Applied Clay Science, Volume 217Author(s): Jie Hu, Sheng Xu, Jia-Xin Ma, Kun Wu, Yi-Hui Guo, Ling-Zhi Ding, Jin-Feng Peng, Qing Hu, Han Wang, Hong-Yan Zeng\nLDH nanosheets anchored on bacterial cellulose-based composite anion\nexchange membranes for significantly enhanced strength and ionic\nAbstract: Publication date: February 2022Source: Applied Clay Science, Volume 217Author(s): Jing Ni, Jie Wang, Shujun Zhao, Fei Zhong, Ting Qu, Fuqiang Hu, Hai Liu, Chunli Gong, Sheng Wen\nZnAl layered double hydroxide based catalysts (with Cu, Mn, Ti) used as\nnoble metal-free three-way catalysts\nAbstract: Publication date: February 2022Source: Applied Clay Science, Volume 217Author(s): Tim Van Everbroeck, Jianxiong Wu, Daniel Arenas-Esteban, Radu-George Ciocarlan, Myrjam Mertens, Sara Bals, Christophe Dujardin, Pascal Granger, Elena M. Seftel, Pegie Cool\nPheromone enclosed in halloysite with n-octadecane releases rhythmically\nunder simulated diurnal temperature\nAbstract: Publication date: February 2022Source: Applied Clay Science, Volume 217Author(s): Xing Li, Ya Wen, Yulian Zhang, Zhiqiang Ge\nEnhanced removal of Cr(VI) and Mo(VI) from polluted water using L-cysteine\ndoped polypyrrole/bentonite composite\nAbstract: Publication date: February 2022Source: Applied Clay Science, Volume 217Author(s): Lei Wang, Haris Muhammad, Minwang Laipan, Xiaohu Fan, Junkang Guo, Yongtao Li


url: =2smoking 1Chinese 1SAGE 1SDG 10 1Sustainable Development Goals 1air pollution 1chronic disease 1chronic non-communicable diseases 1cobalt 1cognitive performance 1depression 1diagnosis 1electrocatalysts 1exercise 1fruit 1gadolinium 1low and middle-income countries 1low- and middle-income countries 1non-communicable diseases 1obesity\n5Guo, Yanfei 5Kowal, Paul 5Wu, Fan 3Chatterji, Somnath 3Ma, Wenjun 2Arokiasamy, Perianayagam 2Biritwum, Richard B. 2Di, Qian 2Lin, Hualiang 2Maximova, Tamara 2Minicuci, Nadia 2Naidoo, Nirmala 2Qian, Zhengmin 2Salinas-Rodriguez, Aaron 2Thiele, Elizabeth 2Yawson, Alfred E. 1Airhihenbuwa, Collins O. 1Barrett, Tyler M. 1Biritwum, Richard\n32017 12015 12016 12020


url: =Programmable Amplifier and Low-pass Filter System--《Electronic Measurement Technology》2002年03期\n《Electronic Measurement Technology》 2002-03\nProgrammable Amplifier and Low-pass Filter System\nZheng Longxi Lei Lei Hu Zhengfeng\nThe structures and working principles of the PGA204 and PGA205 programmable instrumentation amplifiers, 8th order low - pass switched - capacitor filter(MAX292), 8254 timer/counter are discussed in brief. A method of acquiring programmable amplifier and low - pass filter system is suggested too.\n1 LI Li, JIA Hai-Ying, LI Xin (Tianjin Vocational Institute, Tianjin 300410, China);On Design of Low-pass Chebyshev Type Impedance Matching Network[J];Development & Innovation of Machinery & Electrical Products;2010-02\n3 SHI Yu-jun(Dept.Phys.,Hexi University,Zhangye 734000,Gansu,China);Digital programmable filter[J];Journal of Baoji University of Arts and Sciences(Natural Science Edition);2008-02\n4 ;可控滤波器设计和实现[J];Journal of Chengdu Electromechanical College;2008-02\n6 FENG Na,SHANG Qiu-feng(North China Electronic Power University,Baoding 071003,Hebei,China);Research development on the digital interface of electronic current transformer[J];Electrical Measurement & Instrumentation;2007-06\n7 XIE Yue1, 2, XU Jing1 (1. School of Electromechanical Engineering, China Jiliang University, Hangzhou 310018, China; 2. Department of Electrical Engineering, The Hong Kong Polytechnic University, Hong Kong, China);Research on calibration technique for analog output of electronic current transformers[J];Electrical Measurement & Instrumentation;2007-09\n8 ZHANG Peng-he1,2,HE Jun-jia2,LU Yi-biao3,WANG Bao-sheng4(1.State Grid Electric Power Research Institute monitor the Technology Research Institute,Wuhan 430074,China.2.Huazhong University of Science and Technology,Wuhan 430074,China.3.Heilongjiang Electric Power Research Institute,Harbin 150030,China.4.Xinjiang Electric Power Research Institute,Wulumuqi 830000,China);Research for Electronic Instrument Transforms Error Calibration Device[J];Electrical Measurement & Instrumentation;2009-01\n9 Zhang Xinfa Dai Yisong Wei Xiaoli(Jilin University of Technology);The Study of Measuring nV Grade LowFrequency Alternative VoltageUsing Digital Lockin Method[J];TRANSACTIONS OF CHINA ELECTROTECHNICAL SOCIETY;1998-03\n10 WANG Tian1, Celestino A Corral3, YANG Shi-zhong2 ( 1. Computer Science and Information Engineering College of Chongqing Technology and Business University, Chongqing 400067, China; 2. Communication Engineering College of Chongqing University, Chongqing, 400044, China; 3. Motorola Inc., Plantation, Florida, 33322, USA );A technique for optimizing the band-edge characteristics of elliptic function filter[J];Journal of Circuits and Systems;2005-05\n1 WANG Meng,WANG Chun-ling(School of Physics and Electronic Engineering,Taishan University,Tai'an,271021,China);Realization of Microwave Low-pass Filter in Experimental Teaching[J];Journal of Taishan University;2011-03


url: =Company Overview - Zhongshan Xuyang Sports Products Co., Ltd.\nKick Scooter, Adult Scooter, Kid Kick Scooter manufacturer / supplier in China, offering 4 PU Wheel Scooter for Kids (BX-4M002), Children Scooters for Sale (BX-1103B), Push Scooters with Two PU Wheel (BX-2MBB145) and so on.\nYear of Establishment: 2010-05-19\nZhongshan Xuyang Sports Products Co., Ltd established in July 2010 mainly manufactures adults & children kick scooters. We are located in Xiaolan town, Zhongshan City, adjacent to Pearl River Delta, which offers favorable conditions for air & sea shipping.\nCertificates Baixi Trademark Registration Certificate View More \nBulletin Board 2016-3-29: More Informations have been added to our scooter web View More \nCompany Show ASSEMBLEY View More 


url: =《Journal of Hubei University of Technology》-1999-03\nCurrent Pos:Journals>(C) Architecture/ Energy/ Traffic/ Electromechanics, etc>(C) Architecture/ Energy/ Traffic/ Electromechanics, etc>Journal of Hubei University of Technology\nJournal of Hubei University of Technology\nThe Principle of Network Database Parallel Control and Serial Number Ceneration ZHANG Ying-jiang; JIA Yi-qing(Computer Centre, Hubei Polytechnic Univ., Wuhan 430068 China People's Construction Bark of China, Beijing 100010 China)\nThe Programming Feature of Mathematica MA Cheng-zhang(DeP. of Basic Courses, Hubei Polytechnic Univ., Wuhan 430068 China )\nRebuilding the Enterprise Conventional MIS By Means of Intranet Technology CHEN Ping ;CHEN Nian-shen; HUANG Li-li(Dep. of Computer , Hubei Techers College, Huangshi 435002 China ;Dep. of Computer , Hubei Polytechnic Univ, Huangshi 430002 China;Dep. of Mechanical Engineering, Hubei Polytechnic Univ.,Wuhan 430068 China)\nResearch on Automatic online Programming System of Feature-based Input NC Turning YANG Guang-you; Hua Zhong-ping; ZHANG Jian-gang ;ZHOU Guo-zhu; SU Xu-wu; HU Song-lin(Dep. of Mechamcal Engineering Hubei Polytechnic Univ., Wuhan 130068, China)\nDevelopment of a Principal and Subordinate Computer Controlling and Managing System Based on Gas Station XU Wei; HU Da-ze; HE Geng-ying(Dep. of Mechanical Engineering, Hubei Polytechnic Univ., Wuhan 430068 China;Institute of Adult Education, Hubei Polytechnic Univ., Wuhan 430068 China)\nSelf-Positioning Methods of Accurary Inspection For Free-Form Surface ZHANG Ye-peng; HUA Zhong-ping; WANG Chang-wen; SU Xu-wu;HU Song-lin(Dep. of Mechanical Engineering, Hubei Polytechnic Univ,, Wuhan 430068 Chiria)\nAn Analysis of the Gas Replacement of the oil Tanker's Inert Gas System YU Xiao-qin;FU Feng-lan(Dep. of Mechanical engineering, Hubei Polytechnic Univ., Wuhan 430068 China;Wuhan Automotive Polytechnic Univ., Wuhan 430070 China)\nResistance to High Temperature Corrosion YANG Yong-qin(Dep. Of Mechanical engineering, Hubei Polytechnic Univ., Wuhan 430068 China)\nReliability Analysis of Pressure Vessels With Different Strength Theories LIU li-fang(Dep. of Mechanical Engineering,Hubei Institute of Chemical Technology, Wuhan 430074 China)\nStudy on Multifunctional Inverter Power Source ZHANG Yu-feng; ZHOU Ren-bin; LI Zhen-Jin; CHUI Feng(Wuhan Ordnance Noncommissioned Officer School Wuhan 430064 China)\nDecentralized Predictive Control Based Upon Estimation of Interconnections LIAO Dong-chu(Dep. of Eletrical Engineering & Computer Science Computer & Application Program,ubei Polytechnic Univ., Wuhan 430068 China)\nResearch on Accuracy Matching of Three-dimensional Traverse by Electronic Total Station LIU Wen-sheng(Dep. of Civil Engineering & Architecture,Hubei Polytechnic Univ., Wuhan, 430068, China )\nTreatment and Research on Deviation of Tamping Pedestal Pile Foundation YAO Fu-chang; WANG Shi-qi; ZHU Quo-shong; CHAI Jie; HU Jun-an(Dep. of Civil Engineering & Architecture,Hubei Polytechnic Univ., Wuhan 430068 China)\nA Compound system's Stable Vibration of Reginal Matrix YANG Ce-ping; WANG Zhi-tian(Dec. of Basic Courses, Hubei Polytechnic Univ Wuhan 430068 China)\nA Test of Submerged Culture about B Edulis in OALR ZHANG Hua-shan; Li Shi-jie(Dep. of Chemical Engineering Hubei Polytechnic Univ.,Wuhan 430068 China)\nDetermination of Imidacloprid by High Performance Liquid Chromatographic CHEN Mao-bin; CHEN Kun; CHENG Zhong-xin; ZHANG Zhi(Dep. of Biological Engineering;Dep.of Chemical Engineering Hubei Polytechnic Univ. , Wuhan 430068 China)\nPractice and Prospect of Reinforced Preparation and Particular Pigestion of Straws NIE Qing; NlE Xun-zai(Dop. of Chemical Engineering Hubei Poloytechnic Univ., Wuhun 430068 China)\nDesign and Application of Extrusion Complex Die on Unplasticized PVC Pipes YAN Hai-biao; CHEN Xu-huang; Li Hua-xin(Dep. of Chemical Engineering Hubei Polytechnic Univ.,Wuhan 430068 China)\nSynthesis of Gelatin-based No-Fogging Coating LI Xue-feng;YU Wei-xing;CHEN Xu-hang;HU Ai-hong; SHI Biao(Dep. of Chemical Engineering, HuBei Polytechnic Univ., Wuhan 430068 China)\nPhotochroicm Compounds and Its Application CHU Heng; LI Chun-qing;CHEN Xu-huang;WANG Yan-wu(Dep. of Chemical Engineering, Hubei Polythenic Univ., Wuhan 430068 China)\n1999 Issues：   [Z1]


url: =当前位置：首页 >曾宝仪 >印度也要登月\t！“广寒宫”为何又热闹了？ 正文\n时间：2019-10-21 07:21:14 来源：酌水知源网 作者：姜彩二\n如果一个产品一个业务，登月以烧钱为手段，以创造和强化伪需求为目标......算了，这种例子不需要解读，这几年这种项目实在太多了，屍体俯拾皆是。用腾讯浏览指数搜索“英雄联盟”得出的数据显示\t，广寒宫为热闹《英雄联盟》的用户年龄中11-20岁的最多，广寒宫为热闹其次是21-30岁，从这里也可以看出目前社会上主流游戏玩家的年龄分布和占比，而更加值得关注的是《英雄联盟》的男女比例，腾讯浏览指数显示女性占比不足10%，这也充分说明了《英雄联盟》是一款更加具有挑战性和上手难度的游戏\t，把一大部分的女性用户排除在了门外。\n而社交到底是什麽，何又社交的本质又是什麽?一种普遍的说法是社交是人类判别自我存在的价值，定位自我认同自我的一个必要之物。换句话来说，印度也要《王者荣耀》其实仅仅是拉高了新手的操作水平而已\t，印度也要并没有拉低高端玩家的可操作空间，如果你是一个核心玩家，你照样可以自定义操作\t，然後秀的飞起。\n?在游戏类型方面，登月艾媒谘询数据显示，登月棋牌、酷跑、回合RPG、卡牌、休闲、角色扮演等红海市场游戏类型已趋於饱和，MOBA\t、3D动作、沙盒等蓝海市场有待探索。最终，广寒宫为热闹在2016年的第四季度，广寒宫为热闹即时战略/MOBA类手游高居最受欢迎游戏类型的榜首，而这个时候，红海已成，格局已定，各个游戏公司要麽选择和《王者荣耀》硬拚拚到头破血流\t，要麽就只能去寻找下一片蓝海了。\n·女副局长斥群众“听不懂话” 央视\t：您好大的官威\n·1986年《当年情》，获奖版 最经典\t！\n英国神操作：花2亿英镑捣毁40亿英镑国货 再30亿外购教子有方：家庭中解决方案暮光女与超模前女友复合热吻想做工艺品携4枚子弹乘高铁 海南一大学生被拘5日用户称易到用车叫不到车 无渠道申请退款马云支持西藏乡村教育家搜索引擎优先推送招办官网《银河补习班》曝幕后特辑京城最大绿肺温榆河公园一期明年5月开放国际奥数竞赛成绩公布 中美并列团体总分第一(图)http://wap.jinxun.cc/kja20191021/13771312.htmlhttp://www.qqwangming.net/kja20191021/79418567.htmlhttp://www.qqwangming.net/dmo20191021/95772886.htmlhttp://m.yiqidiao.com/qzs67213633/20191021.htmlhttp://www.yiqidiao.com/kja20191021/91194212.htmlhttp://www.zhuankou.com.cn/qzs15289769/20191021.htmlhttp://m.yiqidiao.com/qzs61772281/20191021.htmlhttp://www.dongcheshike.com/kja20191021/26719174.htmlhttp://www.yiqidiao.com/kja20191021/32514799.htmlhttp://news.jinxun.cc/kja20191021/52725781.htmlhttp://www.dongcheshike.com/mta20191021/75797698.htmlhttp://www.qqwangming.net/qdl20191021/26817651.htmlhttp://www.yiqidiao.com/mta20191021/79126111.htmlhttp://wap.jinxun.cc/qzs20191021/38375183.htmlhttp://www.qqwangming.net/dmo20191021/66232214.htmlhttp://www.zhuankou.com.cn/kja20191021/89565963.htmlhttp://wap.jinxun.cc/mta20191021/97457561.htmlhttp://www.qqwangming.net/kja20191021/39889615.htmlhttp://wap.jinxun.cc/kja20191021/33744883.htmlhttp://news.jinxun.cc/mta20191021/73832461.htmlhttp://www.zhuankou.com.cn/qzs11685298/20191021.htmlhttp://www.qqwangming.net/mta20191021/17614766.htmlhttp://www.qqwangming.net/mta20191021/33714574.htmlhttp://m.yiqidiao.com/qzs84954467/20191021.htmlhttp://news.jinxun.cc/kja20191021/55446869.htmlhttp://www.zhuankou.com.cn/qzs64361443/20191021.htmlhttp://wap.jinxun.cc/kja20191021/61495134.htmlhttp://www.yiqidiao.com/mta20191021/53986562.htmlhttp://www.qqwangming.net/qdl20191021/19667254.htmlhttp://wap.jinxun.cc/qzs20191021/58962397.htmlhttp://www.dongcheshike.com/mta20191021/44684929.htmlhttp://www.dongcheshike.com/kja20191021/32797327.htmlhttp://www.qqwangming.net/dmo20191021/37319845.htmlhttp://news.jinxun.cc/mta20191021/64187162.htmlhttp://wap.jinxun.cc/mta20191021/43982275.htmlhttp://www.zhuankou.com.cn/kja20191021/34517679.htmlhttp://www.yiqidiao.com/kja20191021/39928464.htmlhttp://www.qqwangming.net/kja20191021/87367872.htmlhttp://www.dongcheshike.com/kja20191021/62919746.htmlhttp://www.qqwangming.net/qdl20191021/52363955.htmlhttp://www.dongcheshike.com/mta20191021/82312529.htmlhttp://www.qqwangming.net/mta20191021/31649476.htmlhttp://wap.jinxun.cc/mta20191021/56743197.htmlhttp://www.qqwangming.net/dmo20191021/23442891.htmlhttp://www.zhuankou.com.cn/qzs92127319/20191021.htmlhttp://www.zhuankou.com.cn/kja20191021/47431195.htmlhttp://wap.jinxun.cc/qzs20191021/76917988.htmlhttp://news.jinxun.cc/mta20191021/22341349.htmlhttp://www.yiqidiao.com/kja20191021/45218212.htmlhttp://news.jinxun.cc/kja20191021/95595453.html\nCopyright ? 2016 Powered by 印度也要登月\t！“广寒宫”为何又热闹了？,酌水知源网?? sitemap


url: =Uitterlinden, André G. (13)\nChen, Xuemei (7)\nKritchevsky, Stephen B. (7)\nVölker, Uwe (7)\nO'Connell, Jeffrey R. (6)\n2. A Dinucleotide Deletion in CD24 Confers Protection against Autoimmune Diseases Wang, Lizhong | Lin, Shili | Rammohan, Kottil W | Liu, Zhenqiu | Liu, Jin-qing | Liu, Run-hua | Guinther, Nikki | Lima, Judy | Zhou, Qunmin | Wang, Tony | Zheng, Xincheng | Birmingham, Dan J | Rovin, Brad H | Hebert, Lee A | Wu, Yeeling | Lynn, D. Joanne | Cooke, Glenn | Yu, C. Yung | Zheng, Pan | Liu, Yang\n3. Promotion of Bone Morphogenetic Protein Signaling by Tetraspanins and Glycosphingolipids Liu, Zhiyu | Shi, Herong | Szymczak, Lindsey C. | Aydin, Taner | Yun, Sijung | Constas, Katharine | Schaeffer, Arielle | Ranjan, Sinthu | Kubba, Saad | Alam, Emad | McMahon, Devin E. | He, Jingpeng | Shwartz, Neta | Tian, Chenxi | Plavskin, Yevgeniy | Lindy, Amanda | Dad, Nimra Amir | Sheth, Sunny | Amin, Nirav M. | Zimmerman, Stephanie | Liu, Dennis | Schwarz, Erich M. | Smith, Harold | Krause, Michael W. | Liu, Jun\nPLoS Genetics 2015;11(5):e1005221.\nBone morphogenetic proteins (BMPs) belong to the transforming growth factor β (TGFβ) superfamily of secreted molecules. BMPs play essential roles in multiple developmental and homeostatic processes in metazoans. Malfunction of the BMP pathway can cause a variety of diseases in humans, including cancer, skeletal disorders and cardiovascular diseases. Identification of factors that ensure proper spatiotemporal control of BMP signaling is critical for understanding how this pathway is regulated. We have used a unique and sensitive genetic screen to identify the plasma membrane-localized tetraspanin TSP-21 as a key new factor in the C. elegans BMP-like “Sma/Mab” signaling pathway that controls body size and postembryonic M lineage development. We showed that TSP-21 acts in the signal-receiving cells and genetically functions at the ligand-receptor level. We further showed that TSP-21 can associate with itself and with two additional tetraspanins, TSP-12 and TSP-14, which also promote Sma/Mab signaling. TSP-12 and TSP-14 can also associate with SMA-6, the type I receptor of the Sma/Mab pathway. Finally, we found that glycosphingolipids, major components of the tetraspanin-enriched microdomains, are required for Sma/Mab signaling. Our findings suggest that the tetraspanin-enriched membrane microdomains are important for proper BMP signaling. As tetraspanins have emerged as diagnostic and prognostic markers for tumor progression, and TSP-21, TSP-12 and TSP-14 are all conserved in humans, we speculate that abnormal BMP signaling due to altered expression or function of certain tetraspanins may be a contributing factor to cancer development.\n5. Plant-Symbiotic Fungi as Chemical Engineers: Multi-Genome Analysis of the Clavicipitaceae Reveals Dynamics of Alkaloid Loci Schardl, Christopher L. | Young, Carolyn A. | Hesse, Uljana | Amyotte, Stefan G. | Andreeva, Kalina | Calie, Patrick J. | Fleetwood, Damien J. | Haws, David C. | Moore, Neil | Oeser, Birgitt | Panaccione, Daniel G. | Schweri, Kathryn K. | Voisey, Christine R. | Farman, Mark L. | Jaromczyk, Jerzy W. | Roe, Bruce A. | O'Sullivan, Donal M. | Scott, Barry | Tudzynski, Paul | An, Zhiqiang | Arnaoudova, Elissaveta G. | Bullock, Charles T. | Charlton, Nikki D. | Chen, Li | Cox, Murray | Dinkins, Randy D. | Florea, Simona | Glenn, Anthony E. | Gordon, Anna | Güldener, Ulrich | Harris, Daniel R. | Hollin, Walter | Jaromczyk, Jolanta | Johnson, Richard D. | Khan, Anar K. | Leistner, Eckhard | Leuchtmann, Adrian | Li, Chunjie | Liu, JinGe | Liu, Jinze | Liu, Miao | Mace, Wade | Machado, Caroline | Nagabhyru, Padmaja | Pan, Juan | Schmid, Jan | Sugawara, Koya | Steiner, Ulrike | Takach, Johanna E. | Tanaka, Eiji | Webb, Jennifer S. | Wilson, Ella V. | Wiseman, Jennifer L. | Yoshida, Ruriko | Zeng, Zheng\nPLoS Genetics 2013;9(2):e1003323.\n6. Genome-Wide Association Study Identifies a Novel Susceptibility Locus at 12q23.1 for Lung Squamous Cell Carcinoma in Han Chinese Dong, Jing | Jin, Guangfu | Wu, Chen | Guo, Huan | Zhou, Baosen | Lv, Jiachun | Lu, Daru | Shi, Yongyong | Shu, Yongqian | Xu, Lin | Chu, Minjie | Wang, Cheng | Zhang, Ruyang | Dai, Juncheng | Jiang, Yue | Yu, Dianke | Ma, Hongxia | Zhao, Xueying | Yin, Zhihua | Yang, Lei | Li, Zhiqiang | Deng, Qifei | Cao, Songyu | Qin, Zhenzhen | Gong, Jianhang | Sun, Chongqi | Wang, Jiucun | Wu, Wei | Zhou, Guoquan | Chen, Hongyan | Guan, Peng | Chen, Yijiang | Liu, Xiangyang | Liu, Li | Xu, Pin | Han, Baohui | Bai, Chunxue | Zhao, Yuxia | Zhang, Haibo | Yan, Ying | Liu, Jibin | Amos, Christopher I. | Chen, Feng | Tan, Wen | Jin, Li | Wu, Tangchun | Hu, Zhibin | Lin, Dongxin | Shen, Hongbing\n7. A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation Coviello, Andrea D. | Haring, Robin | Wellons, Melissa | Vaidya, Dhananjay | Lehtimäki, Terho | Keildson, Sarah | Lunetta, Kathryn L. | He, Chunyan | Fornage, Myriam | Lagou, Vasiliki | Mangino, Massimo | Onland-Moret, N. Charlotte | Chen, Brian | Eriksson, Joel | Garcia, Melissa | Liu, Yong Mei | Koster, Annemarie | Lohman, Kurt | Lyytikäinen, Leo-Pekka | Petersen, Ann-Kristin | Prescott, Jennifer | Stolk, Lisette | Vandenput, Liesbeth | Wood, Andrew R. | Zhuang, Wei Vivian | Ruokonen, Aimo | Hartikainen, Anna-Liisa | Pouta, Anneli | Bandinelli, Stefania | Biffar, Reiner | Brabant, Georg | Cox, David G. | Chen, Yuhui | Cummings, Steven | Ferrucci, Luigi | Gunter, Marc J. | Hankinson, Susan E. | Martikainen, Hannu | Hofman, Albert | Homuth, Georg | Illig, Thomas | Jansson, John-Olov | Johnson, Andrew D. | Karasik, David | Karlsson, Magnus | Kettunen, Johannes | Kiel, Douglas P. | Kraft, Peter | Liu, Jingmin | Ljunggren, Östen | Lorentzon, Mattias | Maggio, Marcello | Markus, Marcello R. P. | Mellström, Dan | Miljkovic, Iva | Mirel, Daniel | Nelson, Sarah | Morin Papunen, Laure | Peeters, Petra H. M. | Prokopenko, Inga | Raffel, Leslie | Reincke, Martin | Reiner, Alex P. | Rexrode, Kathryn | Rivadeneira, Fernando | Schwartz, Stephen M. | Siscovick, David | Soranzo, Nicole | Stöckl, Doris | Tworoger, Shelley | Uitterlinden, André G. | van Gils, Carla H. | Vasan, Ramachandran S. | Wichmann, H.-Erich | Zhai, Guangju | Bhasin, Shalender | Bidlingmaier, Martin | Chanock, Stephen J. | De Vivo, Immaculata | Harris, Tamara B. | Hunter, David J. | Kähönen, Mika | Liu, Simin | Ouyang, Pamela | Spector, Tim D. | van der Schouw, Yvonne T. | Viikari, Jorma | Wallaschofski, Henri | McCarthy, Mark I. | Frayling, Timothy M. | Murray, Anna | Franks, Steve | Järvelin, Marjo-Riitta | de Jong, Frank H. | Raitakari, Olli | Teumer, Alexander | Ohlsson, Claes | Murabito, Joanne M. | Perry, John R. B.\n8. GWAS Identifies Novel Susceptibility Loci on 6p21.32 and 21q21.3 for Hepatocellular Carcinoma in Chronic Hepatitis B Virus Carriers Li, Shengping | Qian, Ji | Yang, Yuan | Zhao, Wanting | Dai, Juncheng | Bei, Jin-Xin | Foo, Jia Nee | McLaren, Paul J. | Li, Zhiqiang | Yang, Jingmin | Shen, Feng | Liu, Li | Yang, Jiamei | Li, Shuhong | Pan, Shandong | Wang, Yi | Li, Wenjin | Zhai, Xiangjun | Zhou, Boping | Shi, Lehua | Chen, Xinchun | Chu, Minjie | Yan, Yiqun | Wang, Jun | Cheng, Shuqun | Shen, Jiawei | Jia, Weihua | Liu, Jibin | Yang, Jiahe | Wen, Zujia | Li, Aijun | Zhang, Ying | Zhang, Guoliang | Luo, Xianrong | Qin, Hongbo | Chen, Minshan | Wang, Hua | Jin, Li | Lin, Dongxin | Shen, Hongbing | He, Lin | de Bakker, Paul I. W. | Wang, Hongyang | Zeng, Yi-Xin | Wu, Mengchao | Hu, Zhibin | Shi, Yongyong | Liu, Jianjun | Zhou, Weiping\n9. ARGONAUTE10 and ARGONAUTE1 Regulate the Termination of Floral Stem Cells through Two MicroRNAs in Arabidopsis Ji, Lijuan | Liu, Xigang | Yan, Jun | Wang, Wenming | Yumul, Rae Eden | Kim, Yun Ju | Dinh, Thanh Theresa | Liu, Jun | Cui, Xia | Zheng, Binglian | Agarwal, Manu | Liu, Chunyan | Cao, Xiaofeng | Tang, Guiliang | Chen, Xuemei\n10. Genome-Wide Association Analyses Identify SPOCK as a Key Novel Gene Underlying Age at Menarche Liu, Yao-Zhong | Guo, Yan-Fang | Wang, Liang | Tan, Li-Jun | Liu, Xiao-Gang | Pei, Yu-Fang | Yan, Han | Xiong, Dong-Hai | Deng, Fei-Yan | Yu, Na | Zhang, Yin-Ping | Zhang, Lei | Lei, Shu-Feng | Chen, Xiang-Ding | Liu, Hong-Bin | Zhu, Xue-Zhen | Levy, Shawn | Papasian, Christopher J. | Drees, Betty M. | Hamilton, James J. | Recker, Robert R. | Deng, Hong-Wen\n11. MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice Lin, Xiaolin | Qin, Yujuan | Jia, Junshuang | Lin, Taoyan | Lin, Xia | Chen, Li | Zeng, Hui | Han, Yanjiang | Wu, Lihong | Huang, Shun | Wang, Meng | Huang, Shenhao | Xie, Raoying | Liang, Liqi | Liu, Yu | Liu, Ruiyu | Zhang, Tingting | Li, Jing | Wang, Shengchun | Sun, Penghui | Huang, Wenhua | Yao, Kaitai | Xu, Kang | Du, Tao | Xiao, Dong\nPLoS Genetics 2016;12(10):e1006308.\nmiR-155 plays critical roles in numerous physiological and pathological processes, however, its function in the regulation of blood glucose homeostasis and insulin sensitivity and underlying mechanisms remain unknown. Here, we reveal that miR-155 levels are downregulated in serum from type 2 diabetes (T2D) patients, suggesting that miR-155 might be involved in blood glucose control and diabetes. Gain-of-function and loss-of-function studies in mice demonstrate that miR-155 has no effects on the pancreatic β-cell proliferation and function. Global transgenic overexpression of miR-155 in mice leads to hypoglycaemia, improved glucose tolerance and insulin sensitivity. Conversely, miR-155 deficiency in mice causes hyperglycemia, impaired glucose tolerance and insulin resistance. In addition, consistent with a positive regulatory role of miR-155 in glucose metabolism, miR-155 positively modulates glucose uptake in all cell types examined, while mice overexpressing miR-155 transgene show enhanced glycolysis, and insulin-stimulated AKT and IRS-1 phosphorylation in liver, adipose tissue or skeletal muscle. Furthermore, we reveal these aforementioned phenomena occur, at least partially, through miR-155-mediated repression of important negative regulators (i.e. C/EBPβ, HDAC4 and SOCS1) of insulin signaling. Taken together, these findings demonstrate, for the first time, that miR-155 is a positive regulator of insulin sensitivity with potential applications for diabetes treatment.\nIn the present study, we provide evidence for the first time showing that miR-155 is a positive regulator of insulin sensitivity in mice. Here, we determine that miR-155 levels are downregulated in serum from type 2 diabetes (T2D) patients, and shows a negative correlation with HOMA-IR, suggesting that miR-155 might be involved in glucose homeostasis and insulin action. Global transgenic overexpression of miR-155 in mice leads to hypoglycaemia, improved glucose tolerance and insulin sensitivity. Conversely, miR-155 deficiency in mice causes hyperglycemia, impaired glucose tolerance and insulin resistance. In addition, consistent with a positive regulatory role of miR-155 in glucose metabolism, miR-155 positively modulates glucose uptake in all cell types examined, while mice overexpressing miR-155 transgene show enhanced glycolysis, and insulin-stimulated AKT and IRS-1 phosphorylation in liver, adipose tissue or skeletal muscle. More importantly, we reveal that these aforementioned phenomena occur, at least in part, through the miR-155-mediated coordinated repression of multiple negative regulators (i.e. C/EBPβ, HDAC4 and SOCS1) of insulin signaling.\n12. dBRWD3 Regulates Tissue Overgrowth and Ectopic Gene Expression Caused by Polycomb Group Mutations Shih, Hsueh-Tzu | Chen, Wei-Yu | Liu, Kwei-Yan | Shih, Zong-Siou | Chen, Yi-Jyun | Hsieh, Paul-Chen | Kuo, Kuan-Lin | Huang, Kuo-How | Hsu, Pang-Hung | Liu, Ya-Wen | Chan, Shih-Peng | Lee, Hsiu-Hsiang | Tsai, Yu-Chen | Wu, June-Tai\nPLoS Genetics 2016;12(9):e1006262.\nTo maintain a particular cell fate, a unique set of genes should be expressed while another set is repressed. One way to repress gene expression is through Polycomb group (PcG) proteins that compact chromatin into a silent configuration. In addition to cell fate maintenance, PcG proteins also maintain normal cell physiology, for example cell cycle. In the absence of PcG, ectopic activation of the PcG-repressed genes leads to developmental defects and malignant tumors. Little is known about the molecular nature of ectopic gene expression; especially what differentiates expression of a given gene in the orthotopic tissue (orthotopic expression) and the ectopic expression of the same gene due to PcG mutations. Here we present that ectopic gene expression in PcG mutant cells specifically requires dBRWD3, a negative regulator of HIRA/Yemanuclein (YEM)-mediated histone variant H3.3 deposition. dBRWD3 mutations suppress both the ectopic gene expression and aberrant tissue overgrowth in PcG mutants through a YEM-dependent mechanism. Our findings identified dBRWD3 as a critical regulator that is uniquely required for ectopic gene expression and aberrant tissue overgrowth caused by PcG mutations.\nGenetic information is stored in our genomic DNA, and different cells retrieve distinct sets of information from our genome. While it is important to activate genomic regions encoding proteins that are essential for a given cell type, it is equally important to silence genomic regions encoding proteins that are potentially harmful to this type of cells. One of the gene silencing mechanisms frequently used during and after development is mediated by the Polycomb group (PcG) proteins. If this guardian function does not perform correctly due to PcG mutations, genes that are normally silenced—such as oncogenes—are expressed aberrantly. Due to the activation of oncogenes and the loss of other PcG functions, PcG mutant cells often begin to display hallmarks of cancer, such as proliferating beyond control, acquiring stem-cell-like properties, and migrating to distant sites. If the transcriptional mechanisms underlying aberrant gene expression in PcG-mutant cancer cells differ from gene expression in normal cells, we may be able to selectively inhibit the growth of cancer cells without affecting their normal counterparts. Here we show that the difference between these two types of gene expression resides in their sensitivity to dBRWD3, a negative regulator of the deposition of histone H3 variant H3.3. Our results indicate that the inactivation of dBRWD3 or promotion of H3.3 deposition may selectively suppress ectopic gene expression and tumorigenesis driven by mutations in PcG.\n13. Arabidopsis COG Complex Subunits COG3 and COG8 Modulate Golgi Morphology, Vesicle Trafficking Homeostasis and Are Essential for Pollen Tube Growth Tan, Xiaoyun | Cao, Kun | Liu, Feng | Li, Yingxin | Li, Pengxiang | Gao, Caiji | Ding, Yu | Lan, Zhiyi | Shi, Zhixuan | Rui, Qingchen | Feng, Yihong | Liu, Yulong | Zhao, Yanxue | Wu, Chengyun | Zhang, Qian | Li, Yan | Jiang, Liwen | Bao, Yiqun\nPLoS Genetics 2016;12(7):e1006140.\nIn the pistils of flowering plants, pollen tubes elongate at the tips to deliver the male gametes to the egg cells for fertilization. The tip growth of pollen tube is due to the deposition of cell membranes and wall materials at a restricted tip area of the plasma membrane. Vesicle trafficking events occurred at the extreme tips have been shown to be required for the coordinated tip growth, while other trafficking pathways are less well characterized. On the other hand, little is known about the molecular mechanisms and the physiological impact of Golgi trafficking and Golgi structure maintenance in plant cells. COG complex is a vesicle tethering factor supposed to mediate intra-Golgi retrograde transport in mammalian and yeast cells. By characterization of two plant COG complex subunits COG3 and COG8, we revealed their roles in Golgi transport and Golgi structure maintenance, which are essential for pollen tube polar growth. These results deepened our understandings on pollen tube growth regulation, and the molecular mechanisms of Golgi trafficking and Golgi morphology maintenance in plant cells.\n14. Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study Winkler, Thomas W. | Justice, Anne E. | Graff, Mariaelisa | Barata, Llilda | Feitosa, Mary F. | Chu, Su | Czajkowski, Jacek | Esko, Tõnu | Fall, Tove | Kilpeläinen, Tuomas O. | Lu, Yingchang | Mägi, Reedik | Mihailov, Evelin | Pers, Tune H. | Rüeger, Sina | Teumer, Alexander | Ehret, Georg B. | Ferreira, Teresa | Heard-Costa, Nancy L. | Karjalainen, Juha | Lagou, Vasiliki | Mahajan, Anubha | Neinast, Michael D. | Prokopenko, Inga | Simino, Jeannette | Teslovich, Tanya M. | Jansen, Rick | Westra, Harm-Jan | White, Charles C. | Absher, Devin | Ahluwalia, Tarunveer S. | Ahmad, Shafqat | Albrecht, Eva | Alves, Alexessander Couto | Bragg-Gresham, Jennifer L. | de Craen, Anton J. M. | Bis, Joshua C. | Bonnefond, Amélie | Boucher, Gabrielle | Cadby, Gemma | Cheng, Yu-Ching | Chiang, Charleston W. K. | Delgado, Graciela | Demirkan, Ayse | Dueker, Nicole | Eklund, Niina | Eiriksdottir, Gudny | Eriksson, Joel | Feenstra, Bjarke | Fischer, Krista | Frau, Francesca | Galesloot, Tessel E. | Geller, Frank | Goel, Anuj | Gorski, Mathias | Grammer, Tanja B. | Gustafsson, Stefan | Haitjema, Saskia | Hottenga, Jouke-Jan | Huffman, Jennifer E. | Jackson, Anne U. | Jacobs, Kevin B. | Johansson, Åsa | Kaakinen, Marika | Kleber, Marcus E. | Lahti, Jari | Mateo Leach, Irene | Lehne, Benjamin | Liu, Youfang | Lo, Ken Sin | Lorentzon, Mattias | Luan, Jian'an | Madden, Pamela A. F. | Mangino, Massimo | McKnight, Barbara | Medina-Gomez, Carolina | Monda, Keri L. | Montasser, May E. | Müller, Gabriele | Müller-Nurasyid, Martina | Nolte, Ilja M. | Panoutsopoulou, Kalliope | Pascoe, Laura | Paternoster, Lavinia | Rayner, Nigel W. | Renström, Frida | Rizzi, Federica | Rose, Lynda M. | Ryan, Kathy A. | Salo, Perttu | Sanna, Serena | Scharnagl, Hubert | Shi, Jianxin | Smith, Albert Vernon | Southam, Lorraine | Stančáková, Alena | Steinthorsdottir, Valgerdur | Strawbridge, Rona J. | Sung, Yun Ju | Tachmazidou, Ioanna | Tanaka, Toshiko | Thorleifsson, Gudmar | Trompet, Stella | Pervjakova, Natalia | Tyrer, Jonathan P. | Vandenput, Liesbeth | van der Laan, Sander W | van der Velde, Nathalie | van Setten, Jessica | van Vliet-Ostaptchouk, Jana V. | Verweij, Niek | Vlachopoulou, Efthymia | Waite, Lindsay L. | Wang, Sophie R. | Wang, Zhaoming | Wild, Sarah H. | Willenborg, Christina | Wilson, James F. | Wong, Andrew | Yang, Jian | Yengo, Loïc | Yerges-Armstrong, Laura M. | Yu, Lei | Zhang, Weihua | Zhao, Jing Hua | Andersson, Ehm A. | Bakker, Stephan J. L. | Baldassarre, Damiano | Banasik, Karina | Barcella, Matteo | Barlassina, Cristina | Bellis, Claire | Benaglio, Paola | Blangero, John | Blüher, Matthias | Bonnet, Fabrice | Bonnycastle, Lori L. | Boyd, Heather A. | Bruinenberg, Marcel | Buchman, Aron S | Campbell, Harry | Chen, Yii-Der Ida | Chines, Peter S. | Claudi-Boehm, Simone | Cole, John | Collins, Francis S. | de Geus, Eco J. C. | de Groot, Lisette C. P. G. M. | Dimitriou, Maria | Duan, Jubao | Enroth, Stefan | Eury, Elodie | Farmaki, Aliki-Eleni | Forouhi, Nita G. | Friedrich, Nele | Gejman, Pablo V. | Gigante, Bruna | Glorioso, Nicola | Go, Alan S. | Gottesman, Omri | Gräßler, Jürgen | Grallert, Harald | Grarup, Niels | Gu, Yu-Mei | Broer, Linda | Ham, Annelies C. | Hansen, Torben | Harris, Tamara B. | Hartman, Catharina A. | Hassinen, Maija | Hastie, Nicholas | Hattersley, Andrew T. | Heath, Andrew C. | Henders, Anjali K. | Hernandez, Dena | Hillege, Hans | Holmen, Oddgeir | Hovingh, Kees G | Hui, Jennie | Husemoen, Lise L. | Hutri-Kähönen, Nina | Hysi, Pirro G. | Illig, Thomas | De Jager, Philip L. | Jalilzadeh, Shapour | Jørgensen, Torben | Jukema, J. Wouter | Juonala, Markus | Kanoni, Stavroula | Karaleftheri, Maria | Khaw, Kay Tee | Kinnunen, Leena | Kittner, Steven J. | Koenig, Wolfgang | Kolcic, Ivana | Kovacs, Peter | Krarup, Nikolaj T. | Kratzer, Wolfgang | Krüger, Janine | Kuh, Diana | Kumari, Meena | Kyriakou, Theodosios | Langenberg, Claudia | Lannfelt, Lars | Lanzani, Chiara | Lotay, Vaneet | Launer, Lenore J. | Leander, Karin | Lindström, Jaana | Linneberg, Allan | Liu, Yan-Ping | Lobbens, Stéphane | Luben, Robert | Lyssenko, Valeriya | Männistö, Satu | Magnusson, Patrik K. | McArdle, Wendy L. | Menni, Cristina | Merger, Sigrun | Milani, Lili | Montgomery, Grant W. | Morris, Andrew P. | Narisu, Narisu | Nelis, Mari | Ong, Ken K. | Palotie, Aarno | Pérusse, Louis | Pichler, Irene | Pilia, Maria G. | Pouta, Anneli | Rheinberger, Myriam | Ribel-Madsen, Rasmus | Richards, Marcus | Rice, Kenneth M. | Rice, Treva K. | Rivolta, Carlo | Salomaa, Veikko | Sanders, Alan R. | Sarzynski, Mark A. | Scholtens, Salome | Scott, Robert A. | Scott, William R. | Sebert, Sylvain | Sengupta, Sebanti | Sennblad, Bengt | Seufferlein, Thomas | Silveira, Angela | Slagboom, P. Eline | Smit, Jan H. | Sparsø, Thomas H. | Stirrups, Kathleen | Stolk, Ronald P. | Stringham, Heather M. | Swertz, Morris A | Swift, Amy J. | Syvänen, Ann-Christine | Tan, Sian-Tsung | Thorand, Barbara | Tönjes, Anke | Tremblay, Angelo | Tsafantakis, Emmanouil | van der Most, Peter J. | Völker, Uwe | Vohl, Marie-Claude | Vonk, Judith M. | Waldenberger, Melanie | Walker, Ryan W. | Wennauer, Roman | Widén, Elisabeth | Willemsen, Gonneke | Wilsgaard, Tom | Wright, Alan F. | Zillikens, M. Carola | van Dijk, Suzanne C. | van Schoor, Natasja M. | Asselbergs, Folkert W. | de Bakker, Paul I. W. | Beckmann, Jacques S. | Beilby, John | Bennett, David A. | Bergman, Richard N. | Bergmann, Sven | Böger, Carsten A. | Boehm, Bernhard O. | Boerwinkle, Eric | Boomsma, Dorret I. | Bornstein, Stefan R. | Bottinger, Erwin P. | Bouchard, Claude | Chambers, John C. | Chanock, Stephen J. | Chasman, Daniel I. | Cucca, Francesco | Cusi, Daniele | Dedoussis, George | Erdmann, Jeanette | Eriksson, Johan G. | Evans, Denis A. | de Faire, Ulf | Farrall, Martin | Ferrucci, Luigi | Ford, Ian | Franke, Lude | Franks, Paul W. | Froguel, Philippe | Gansevoort, Ron T. | Gieger, Christian | Grönberg, Henrik | Gudnason, Vilmundur | Gyllensten, Ulf | Hall, Per | Hamsten, Anders | van der Harst, Pim | Hayward, Caroline | Heliövaara, Markku | Hengstenberg, Christian | Hicks, Andrew A | Hingorani, Aroon | Hofman, Albert | Hu, Frank | Huikuri, Heikki V. | Hveem, Kristian | James, Alan L. | Jordan, Joanne M. | Jula, Antti | Kähönen, Mika | Kajantie, Eero | Kathiresan, Sekar | Kiemeney, Lambertus A. L. M. | Kivimaki, Mika | Knekt, Paul B. | Koistinen, Heikki A. | Kooner, Jaspal S. | Koskinen, Seppo | Kuusisto, Johanna | Maerz, Winfried | Martin, Nicholas G | Laakso, Markku | Lakka, Timo A. | Lehtimäki, Terho | Lettre, Guillaume | Levinson, Douglas F. | Lind, Lars | Lokki, Marja-Liisa | Mäntyselkä, Pekka | Melbye, Mads | Metspalu, Andres | Mitchell, Braxton D. | Moll, Frans L. | Murray, Jeffrey C. | Musk, Arthur W. | Nieminen, Markku S. | Njølstad, Inger | Ohlsson, Claes | Oldehinkel, Albertine J. | Oostra, Ben A. | Palmer, Lyle J | Pankow, James S. | Pasterkamp, Gerard | Pedersen, Nancy L. | Pedersen, Oluf | Penninx, Brenda W. | Perola, Markus | Peters, Annette | Polašek, Ozren | Pramstaller, Peter P. | Psaty, Bruce M. | Qi, Lu | Quertermous, Thomas | Raitakari, Olli T. | Rankinen, Tuomo | Rauramaa, Rainer | Ridker, Paul M. | Rioux, John D. | Rivadeneira, Fernando | Rotter, Jerome I. | Rudan, Igor | den Ruijter, Hester M. | Saltevo, Juha | Sattar, Naveed | Schunkert, Heribert | Schwarz, Peter E. H. | Shuldiner, Alan R. | Sinisalo, Juha | Snieder, Harold | Sørensen, Thorkild I. A. | Spector, Tim D. | Staessen, Jan A. | Stefania, Bandinelli | Thorsteinsdottir, Unnur | Stumvoll, Michael | Tardif, Jean-Claude | Tremoli, Elena | Tuomilehto, Jaakko | Uitterlinden, André G. | Uusitupa, Matti | Verbeek, André L. M. | Vermeulen, Sita H. | Viikari, Jorma S. | Vitart, Veronique | Völzke, Henry | Vollenweider, Peter | Waeber, Gérard | Walker, Mark | Wallaschofski, Henri | Wareham, Nicholas J. | Watkins, Hugh | Zeggini, Eleftheria | Chakravarti, Aravinda | Clegg, Deborah J. | Cupples, L. Adrienne | Gordon-Larsen, Penny | Jaquish, Cashell E. | Rao, D. C. | Abecasis, Goncalo R. | Assimes, Themistocles L. | Barroso, Inês | Berndt, Sonja I. | Boehnke, Michael | Deloukas, Panos | Fox, Caroline S. | Groop, Leif C. | Hunter, David J. | Ingelsson, Erik | Kaplan, Robert C. | McCarthy, Mark I. | Mohlke, Karen L. | O'Connell, Jeffrey R. | Schlessinger, David | Strachan, David P. | Stefansson, Kari | van Duijn, Cornelia M. | Hirschhorn, Joel N. | Lindgren, Cecilia M. | Heid, Iris M. | North, Kari E. | Borecki, Ingrid B. | Kutalik, Zoltán | Loos, Ruth J. F.\n15. RAB-10 Promotes EHBP-1 Bridging of Filamentous Actin and Tubular Recycling Endosomes Wang, Peixiang | Liu, Hang | Wang, Yu | Liu, Ou | Zhang, Jing | Gleason, Adenrele | Yang, Zhenrong | Wang, Hui | Shi, Anbing | Grant, Barth D.\nPLoS Genetics 2016;12(6):e1006093.\nEHBP-1 (Ehbp1) is a conserved regulator of endocytic recycling, acting as an effector of small GTPases including RAB-10 (Rab10). Here we present evidence that EHBP-1 associates with tubular endosomal phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] enriched membranes through an N-terminal C2-like (NT-C2) domain, and define residues within the NT-C2 domain that mediate membrane interaction. Furthermore, our results indicate that the EHBP-1 central calponin homology (CH) domain binds to actin microfilaments in a reaction that is stimulated by RAB-10(GTP). Loss of any aspect of this RAB-10/EHBP-1 system in the C. elegans intestinal epithelium leads to retention of basolateral recycling cargo in endosomes that have lost their normal tubular endosomal network (TEN) organization. We propose a mechanism whereby RAB-10 promotes the ability of endosome-bound EHBP-1 to also bind to the actin cytoskeleton, thereby promoting endosomal tubulation.\nEndosomes are intracellular organelles that sort protein and lipid components integral to the membrane, as well as more loosely associated lumenal content, for delivery to distinct intracellular destinations. Endosomes associated with recycling cargo back to the plasma membrane are often tubular in morphology, and this morphology is thought to be essential for recycling function. Our previous work identified a particularly dramatic network of endosomal tubules involved in membrane protein recycling in the basolateral intestinal epithelial cells of C. elegans. Our subsequent genetic analysis of basolateral recycling in this system identified a number of key regulators of these endosomes, including the small GTPase RAB-10 and its effector EHBP-1. Our new work presented here shows that EHBP-1 promotes endosomal tubulation by linking the membrane lipid PI(4,5)P2 to the actin cytoskeleton, and that the linkage of EHBP-1 to actin is enhanced by the interaction of EHBP-1 with RAB-10. This work has broad implications for how endosomal tubulation occurs in all cells, and has specific implications for the role of EHBP-1 in related processes such as insulin-stimulated recycling of glucose transporters in human adipocytes, a process intimately linked to type II diabetes.\n16. Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure Smith, J. Gustav | Felix, Janine F. | Morrison, Alanna C. | Kalogeropoulos, Andreas | Trompet, Stella | Wilk, Jemma B. | Gidlöf, Olof | Wang, Xinchen | Morley, Michael | Mendelson, Michael | Joehanes, Roby | Ligthart, Symen | Shan, Xiaoyin | Bis, Joshua C. | Wang, Ying A. | Sjögren, Marketa | Ngwa, Julius | Brandimarto, Jeffrey | Stott, David J. | Aguilar, David | Rice, Kenneth M. | Sesso, Howard D. | Demissie, Serkalem | Buckley, Brendan M. | Taylor, Kent D. | Ford, Ian | Yao, Chen | Liu, Chunyu | Sotoodehnia, Nona | van der Harst, Pim | Stricker, Bruno H. Ch. | Kritchevsky, Stephen B. | Liu, Yongmei | Gaziano, J. Michael | Hofman, Albert | Moravec, Christine S. | Uitterlinden, André G. | Kellis, Manolis | van Meurs, Joyce B. | Margulies, Kenneth B. | Dehghan, Abbas | Levy, Daniel | Olde, Björn | Psaty, Bruce M. | Cupples, L. Adrienne | Jukema, J. Wouter | Djousse, Luc | Franco, Oscar H. | Boerwinkle, Eric | Boyer, Laurie A. | Newton-Cheh, Christopher | Butler, Javed | Vasan, Ramachandran S. | Cappola, Thomas P. | Smith, Nicholas L.\nPLoS Genetics 2016;12(5):e1006034.\nIn this study, we applied a genome-wide mapping approach to study molecular determinants of mortality in subjects with heart failure. We identified a genetic variant on chromosome 5q22 that was associated with mortality in this group and observed that this variant conferred increased function of an enhancer region active in multiple tissues. We further observed association of the genetic variant with a DNA methylation signature in blood that in turn is associated with allergy and expression of the gene TSLP (Thymic stromal lymphoprotein) in blood. Knockdown of the transcription factor predicted to bind the enhancer region also resulted in lower TSLP expression. The TSLP gene encodes a cytokine that induces release of T-cell attracting chemokines from monocytes, promotes T helper type 2 cell responses, enhances maturation of dendritic cells and activates mast cells. Development of TSLP inhibiting therapeutics are underway and currently in phase III clinical trials for asthma and allergy. These findings provide novel genetic leads to factors that influence mortality in patients with heart failure and in the longer term may result in novel therapies.\n17. Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients Yang, Hsin-Chou | Chu, Shih-Kai | Huang, Chieh-Liang | Kuo, Hsiang-Wei | Wang, Sheng-Chang | Liu, Sheng-Wen | Ho, Ing-Kang | Liu, Yu-Li\n18. Arabidopsis Flower and Embryo Developmental Genes are Repressed in Seedlings by Different Combinations of Polycomb Group Proteins in Association with Distinct Sets of Cis-regulatory Elements Wang, Hua | Liu, Chunmei | Cheng, Jingfei | Liu, Jian | Zhang, Lei | He, Chongsheng | Shen, Wen-Hui | Jin, Hong | Xu, Lin | Zhang, Yijing\nPLoS Genetics 2016;12(1):e1005771.\nPolycomb repressive complexes (PRCs) play crucial roles in transcriptional repression and developmental regulation in both plants and animals. In plants, depletion of different members of PRCs causes both overlapping and unique phenotypic defects. However, the underlying molecular mechanism determining the target specificity and functional diversity is not sufficiently characterized. Here, we quantitatively compared changes of tri-methylation at H3K27 in Arabidopsis mutants deprived of various key PRC components. We show that CURLY LEAF (CLF), a major catalytic subunit of PRC2, coordinates with different members of PRC1 in suppression of distinct plant developmental programs. We found that expression of flower development genes is repressed in seedlings preferentially via non-redundant role of CLF, which specifically associated with LIKE HETEROCHROMATIN PROTEIN1 (LHP1). In contrast, expression of embryo development genes is repressed by PRC1-catalytic core subunits AtBMI1 and AtRING1 in common with PRC2-catalytic enzymes CLF or SWINGER (SWN). This context-dependent role of CLF corresponds well with the change in H3K27me3 profiles, and is remarkably associated with differential co-occupancy of binding motifs of transcription factors (TFs), including MADS box and ABA-related factors. We propose that different combinations of PRC members distinctively regulate different developmental programs, and their target specificity is modulated by specific TFs.\nPolycomb group proteins (PcGs) are essential for development in both animals and plants. Studies in plants are advantageous for elucidation of specific effects of PcGs during development, since most PcG mutants are viable in plants but not in animals. Previous efforts in genetic study of plant PcGs revealed that different PcGs have both common and unique effects on plant development, but the mechanisms underlying the specific regulation of different developmental programs by PcGs are still far from clear. In this study, we quantitatively compared the change in H3K27me3 and gene expression profiles between mutants of key PcG members on a genome-wide scale in Arabidopsis seedlings, and successfully unraveled different developmental programs that are specifically regulated by different combinations of PcGs. This context specific effect of PcGs is closely associated with different sets of transcription factor binding motifs. Together, we revealed on a genome-wide scale that different combinations of PcGs, as well as their association with the binding sites of different TFs, serve to explain the specific regulation of different developmental programs by PcGs.\n19. Correction: The Roles of Arabidopsis CDF2 in Transcriptional and Posttranscriptional Regulation of Primary MicroRNAs Sun, Zhenfei | Guo, Tongtong | Liu, Yin | Liu, Qi | Fang, Yuda\nPLoS Genetics 2015;11(11):e1005700.\n20. KRN4 Controls Quantitative Variation in Maize Kernel Row Number Liu, Lei | Du, Yanfang | Shen, Xiaomeng | Li, Manfei | Sun, Wei | Huang, Juan | Liu, Zhijie | Tao, Yongsheng | Zheng, Yonglian | Yan, Jianbing | Zhang, Zuxin\nPLoS Genetics 2015;11(11):e1005670.\nMaize (Zea mays L.) is one of the world's most important sources of calories for humans. With an expanding global population, the demands for maize-derived food, feed, and fuel are rapidly increasing. To meet these needs, geneticists and breeders are facing the challenge of enhancing grain yield through genetic improvement of maize germplasm. Understanding the genetic basis of grain yield is necessary to guide breeding efforts towards the development of high-yielding hybrids. Kernel row number (KRN) in maize is one of the most important yield components and a significant breeding target. Over the last few decades, many genes that determine inflorescence development and architecture have been identified and characterized. The formation of kernel rows is an integral part of the development of the female inflorescence in maize. Nevertheless, the genetic basis and molecular regulation of quantitative variation in KRN is poorly understood. This study provides experimental evidence for the hypothesis that variation in intergenic regions can regulate quantitative variation of important grain yield-related traits, and also provides tools for improving KRN in maize.\n21. The Roles of Arabidopsis CDF2 in Transcriptional and Posttranscriptional Regulation of Primary MicroRNAs Sun, Zhenfei | Guo, Tongtong | Liu, Yin | Liu, Qi | Fang, Yuda\nPLoS Genetics 2015;11(10):e1005598.\nCDFs were identified to play roles in the blue light signaling. This study reveals that CDF2 acts as a transcriptional activator or repressor of a group of microRNA (miRNA) genes and binds to the pri-miRNA transcripts. This study demonstrates that CDF2 interacts with the Dicer-like 1 (DCL1) complex and suppresses the processing of primary miRNAs. Genetic analysis shows that CDF2 works in the same pathway as miR156 or miR172 to control flowering. The finding that the miRNA accumulation is regulated by a factor at both the transcriptional and posttranscriptional levels may have a broad impact on the miRNA biogenesis field. The regulation of miRNA abundance by CDF2 sheds light on the roles of miRNAs in the light signaling pathways.\n22. The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study Winkler, Thomas W. | Justice, Anne E. | Graff, Mariaelisa | Barata, Llilda | Feitosa, Mary F. | Chu, Su | Czajkowski, Jacek | Esko, Tõnu | Fall, Tove | Kilpeläinen, Tuomas O. | Lu, Yingchang | Mägi, Reedik | Mihailov, Evelin | Pers, Tune H. | Rüeger, Sina | Teumer, Alexander | Ehret, Georg B. | Ferreira, Teresa | Heard-Costa, Nancy L. | Karjalainen, Juha | Lagou, Vasiliki | Mahajan, Anubha | Neinast, Michael D. | Prokopenko, Inga | Simino, Jeannette | Teslovich, Tanya M. | Jansen, Rick | Westra, Harm-Jan | White, Charles C. | Absher, Devin | Ahluwalia, Tarunveer S. | Ahmad, Shafqat | Albrecht, Eva | Alves, Alexessander Couto | Bragg-Gresham, Jennifer L. | de Craen, Anton J. M. | Bis, Joshua C. | Bonnefond, Amélie | Boucher, Gabrielle | Cadby, Gemma | Cheng, Yu-Ching | Chiang, Charleston W. K. | Delgado, Graciela | Demirkan, Ayse | Dueker, Nicole | Eklund, Niina | Eiriksdottir, Gudny | Eriksson, Joel | Feenstra, Bjarke | Fischer, Krista | Frau, Francesca | Galesloot, Tessel E. | Geller, Frank | Goel, Anuj | Gorski, Mathias | Grammer, Tanja B. | Gustafsson, Stefan | Haitjema, Saskia | Hottenga, Jouke-Jan | Huffman, Jennifer E. | Jackson, Anne U. | Jacobs, Kevin B. | Johansson, Åsa | Kaakinen, Marika | Kleber, Marcus E. | Lahti, Jari | Leach, Irene Mateo | Lehne, Benjamin | Liu, Youfang | Lo, Ken Sin | Lorentzon, Mattias | Luan, Jian'an | Madden, Pamela A. F. | Mangino, Massimo | McKnight, Barbara | Medina-Gomez, Carolina | Monda, Keri L. | Montasser, May E. | Müller, Gabriele | Müller-Nurasyid, Martina | Nolte, Ilja M. | Panoutsopoulou, Kalliope | Pascoe, Laura | Paternoster, Lavinia | Rayner, Nigel W. | Renström, Frida | Rizzi, Federica | Rose, Lynda M. | Ryan, Kathy A. | Salo, Perttu | Sanna, Serena | Scharnagl, Hubert | Shi, Jianxin | Smith, Albert Vernon | Southam, Lorraine | Stančáková, Alena | Steinthorsdottir, Valgerdur | Strawbridge, Rona J. | Sung, Yun Ju | Tachmazidou, Ioanna | Tanaka, Toshiko | Thorleifsson, Gudmar | Trompet, Stella | Pervjakova, Natalia | Tyrer, Jonathan P. | Vandenput, Liesbeth | van der Laan, Sander W | van der Velde, Nathalie | van Setten, Jessica | van Vliet-Ostaptchouk, Jana V. | Verweij, Niek | Vlachopoulou, Efthymia | Waite, Lindsay L. | Wang, Sophie R. | Wang, Zhaoming | Wild, Sarah H. | Willenborg, Christina | Wilson, James F. | Wong, Andrew | Yang, Jian | Yengo, Loïc | Yerges-Armstrong, Laura M. | Yu, Lei | Zhang, Weihua | Zhao, Jing Hua | Andersson, Ehm A. | Bakker, Stephan J. L. | Baldassarre, Damiano | Banasik, Karina | Barcella, Matteo | Barlassina, Cristina | Bellis, Claire | Benaglio, Paola | Blangero, John | Blüher, Matthias | Bonnet, Fabrice | Bonnycastle, Lori L. | Boyd, Heather A. | Bruinenberg, Marcel | Buchman, Aron S | Campbell, Harry | Chen, Yii-Der Ida | Chines, Peter S. | Claudi-Boehm, Simone | Cole, John | Collins, Francis S. | de Geus, Eco J. C. | de Groot, Lisette C. P. G. M. | Dimitriou, Maria | Duan, Jubao | Enroth, Stefan | Eury, Elodie | Farmaki, Aliki-Eleni | Forouhi, Nita G. | Friedrich, Nele | Gejman, Pablo V. | Gigante, Bruna | Glorioso, Nicola | Go, Alan S. | Gottesman, Omri | Gräßler, Jürgen | Grallert, Harald | Grarup, Niels | Gu, Yu-Mei | Broer, Linda | Ham, Annelies C. | Hansen, Torben | Harris, Tamara B. | Hartman, Catharina A. | Hassinen, Maija | Hastie, Nicholas | Hattersley, Andrew T. | Heath, Andrew C. | Henders, Anjali K. | Hernandez, Dena | Hillege, Hans | Holmen, Oddgeir | Hovingh, Kees G | Hui, Jennie | Husemoen, Lise L. | Hutri-Kähönen, Nina | Hysi, Pirro G. | Illig, Thomas | De Jager, Philip L. | Jalilzadeh, Shapour | Jørgensen, Torben | Jukema, J. Wouter | Juonala, Markus | Kanoni, Stavroula | Karaleftheri, Maria | Khaw, Kay Tee | Kinnunen, Leena | Kittner, Steven J. | Koenig, Wolfgang | Kolcic, Ivana | Kovacs, Peter | Krarup, Nikolaj T. | Kratzer, Wolfgang | Krüger, Janine | Kuh, Diana | Kumari, Meena | Kyriakou, Theodosios | Langenberg, Claudia | Lannfelt, Lars | Lanzani, Chiara | Lotay, Vaneet | Launer, Lenore J. | Leander, Karin | Lindström, Jaana | Linneberg, Allan | Liu, Yan-Ping | Lobbens, Stéphane | Luben, Robert | Lyssenko, Valeriya | Männistö, Satu | Magnusson, Patrik K. | McArdle, Wendy L. | Menni, Cristina | Merger, Sigrun | Milani, Lili | Montgomery, Grant W. | Morris, Andrew P. | Narisu, Narisu | Nelis, Mari | Ong, Ken K. | Palotie, Aarno | Pérusse, Louis | Pichler, Irene | Pilia, Maria G. | Pouta, Anneli | Rheinberger, Myriam | Ribel-Madsen, Rasmus | Richards, Marcus | Rice, Kenneth M. | Rice, Treva K. | Rivolta, Carlo | Salomaa, Veikko | Sanders, Alan R. | Sarzynski, Mark A. | Scholtens, Salome | Scott, Robert A. | Scott, William R. | Sebert, Sylvain | Sengupta, Sebanti | Sennblad, Bengt | Seufferlein, Thomas | Silveira, Angela | Slagboom, P. Eline | Smit, Jan H. | Sparsø, Thomas H. | Stirrups, Kathleen | Stolk, Ronald P. | Stringham, Heather M. | Swertz, Morris A | Swift, Amy J. | Syvänen, Ann-Christine | Tan, Sian-Tsung | Thorand, Barbara | Tönjes, Anke | Tremblay, Angelo | Tsafantakis, Emmanouil | van der Most, Peter J. | Völker, Uwe | Vohl, Marie-Claude | Vonk, Judith M. | Waldenberger, Melanie | Walker, Ryan W. | Wennauer, Roman | Widén, Elisabeth | Willemsen, Gonneke | Wilsgaard, Tom | Wright, Alan F. | Zillikens, M. Carola | van Dijk, Suzanne C. | van Schoor, Natasja M. | Asselbergs, Folkert W. | de Bakker, Paul I. W. | Beckmann, Jacques S. | Beilby, John | Bennett, David A. | Bergman, Richard N. | Bergmann, Sven | Böger, Carsten A. | Boehm, Bernhard O. | Boerwinkle, Eric | Boomsma, Dorret I. | Bornstein, Stefan R. | Bottinger, Erwin P. | Bouchard, Claude | Chambers, John C. | Chanock, Stephen J. | Chasman, Daniel I. | Cucca, Francesco | Cusi, Daniele | Dedoussis, George | Erdmann, Jeanette | Eriksson, Johan G. | Evans, Denis A. | de Faire, Ulf | Farrall, Martin | Ferrucci, Luigi | Ford, Ian | Franke, Lude | Franks, Paul W. | Froguel, Philippe | Gansevoort, Ron T. | Gieger, Christian | Grönberg, Henrik | Gudnason, Vilmundur | Gyllensten, Ulf | Hall, Per | Hamsten, Anders | van der Harst, Pim | Hayward, Caroline | Heliövaara, Markku | Hengstenberg, Christian | Hicks, Andrew A | Hingorani, Aroon | Hofman, Albert | Hu, Frank | Huikuri, Heikki V. | Hveem, Kristian | James, Alan L. | Jordan, Joanne M. | Jula, Antti | Kähönen, Mika | Kajantie, Eero | Kathiresan, Sekar | Kiemeney, Lambertus A. L. M. | Kivimaki, Mika | Knekt, Paul B. | Koistinen, Heikki A. | Kooner, Jaspal S. | Koskinen, Seppo | Kuusisto, Johanna | Maerz, Winfried | Martin, Nicholas G | Laakso, Markku | Lakka, Timo A. | Lehtimäki, Terho | Lettre, Guillaume | Levinson, Douglas F. | Lind, Lars | Lokki, Marja-Liisa | Mäntyselkä, Pekka | Melbye, Mads | Metspalu, Andres | Mitchell, Braxton D. | Moll, Frans L. | Murray, Jeffrey C. | Musk, Arthur W. | Nieminen, Markku S. | Njølstad, Inger | Ohlsson, Claes | Oldehinkel, Albertine J. | Oostra, Ben A. | Palmer, Lyle J | Pankow, James S. | Pasterkamp, Gerard | Pedersen, Nancy L. | Pedersen, Oluf | Penninx, Brenda W. | Perola, Markus | Peters, Annette | Polašek, Ozren | Pramstaller, Peter P. | Psaty, Bruce M. | Qi, Lu | Quertermous, Thomas | Raitakari, Olli T. | Rankinen, Tuomo | Rauramaa, Rainer | Ridker, Paul M. | Rioux, John D. | Rivadeneira, Fernando | Rotter, Jerome I. | Rudan, Igor | den Ruijter, Hester M. | Saltevo, Juha | Sattar, Naveed | Schunkert, Heribert | Schwarz, Peter E. H. | Shuldiner, Alan R. | Sinisalo, Juha | Snieder, Harold | Sørensen, Thorkild I. A. | Spector, Tim D. | Staessen, Jan A. | Stefania, Bandinelli | Thorsteinsdottir, Unnur | Stumvoll, Michael | Tardif, Jean-Claude | Tremoli, Elena | Tuomilehto, Jaakko | Uitterlinden, André G. | Uusitupa, Matti | Verbeek, André L. M. | Vermeulen, Sita H. | Viikari, Jorma S. | Vitart, Veronique | Völzke, Henry | Vollenweider, Peter | Waeber, Gérard | Walker, Mark | Wallaschofski, Henri | Wareham, Nicholas J. | Watkins, Hugh | Zeggini, Eleftheria | Chakravarti, Aravinda | Clegg, Deborah J. | Cupples, L. Adrienne | Gordon-Larsen, Penny | Jaquish, Cashell E. | Rao, D. C. | Abecasis, Goncalo R. | Assimes, Themistocles L. | Barroso, Inês | Berndt, Sonja I. | Boehnke, Michael | Deloukas, Panos | Fox, Caroline S. | Groop, Leif C. | Hunter, David J. | Ingelsson, Erik | Kaplan, Robert C. | McCarthy, Mark I. | Mohlke, Karen L. | O'Connell, Jeffrey R. | Schlessinger, David | Strachan, David P. | Stefansson, Kari | van Duijn, Cornelia M. | Hirschhorn, Joel N. | Lindgren, Cecilia M. | Heid, Iris M. | North, Kari E. | Borecki, Ingrid B. | Kutalik, Zoltán | Loos, Ruth J. F.\n23. Synergistic and Dose-Controlled Regulation of Cellulase Gene Expression in Penicillium oxalicum\nLi, Zhonghai | Yao, Guangshan | Wu, Ruimei | Gao, Liwei | Kan, Qinbiao | Liu, Meng | Yang, Piao | Liu, Guodong | Qin, Yuqi | Song, Xin | Zhong, Yaohua | Fang, Xu | Qu, Yinbo\nPLoS Genetics 2015;11(9):e1005509.\nFilamentous fungus Penicillium oxalicum produces diverse lignocellulolytic enzymes, which are regulated by the combinations of many transcription factors. Here, a single-gene disruptant library for 470 transcription factors was constructed and systematically screened for cellulase production. Twenty transcription factors (including ClrB, CreA, XlnR, Ace1, AmyR, and 15 unknown proteins) were identified to play putative roles in the activation or repression of cellulase synthesis. Most of these regulators have not been characterized in any fungi before. We identified the ClrB, CreA, XlnR, and AmyR transcription factors as critical dose-dependent regulators of cellulase expression, the core regulons of which were identified by analyzing several transcriptomes and/or secretomes. Synergistic and additive modes of combinatorial control of each cellulase gene by these regulatory factors were achieved, and cellulase expression was fine-tuned in a proper and controlled manner. With one of these targets, the expression of the major intracellular β-glucosidase Bgl2 was found to be dependent on ClrB. The Bgl2-deficient background resulted in a substantial gene activation by ClrB and proved to be closely correlated with the relief of repression mediated by CreA and AmyR during cellulase induction. Our results also signify that probing the synergistic and dose-controlled regulation mechanisms of cellulolytic regulators and using it for reconstruction of expression regulation network (RERN) may be a promising strategy for cellulolytic fungi to develop enzyme hyper-producers. Based on our data, ClrB was identified as focal point for the synergistic activation regulation of cellulase expression by integrating cellulolytic regulators and their target genes, which refined our understanding of transcriptional-regulatory network as a “seesaw model” in which the coordinated regulation of cellulolytic genes is established by counteracting activators and repressors.\n24. Molecular Basis of Gene-Gene Interaction: Cyclic Cross-Regulation of Gene Expression and Post-GWAS Gene-Gene Interaction Involved in Atrial Fibrillation Huang, Yufeng | Wang, Chuchu | Yao, Yufeng | Zuo, Xiaoyu | Chen, Shanshan | Xu, Chengqi | Zhang, Hongfu | Lu, Qiulun | Chang, Le | Wang, Fan | Wang, Pengxia | Zhang, Rongfeng | Hu, Zhenkun | Song, Qixue | Yang, Xiaowei | Li, Cong | Li, Sisi | Zhao, Yuanyuan | Yang, Qin | Yin, Dan | Wang, Xiaojing | Si, Wenxia | Li, Xiuchun | Xiong, Xin | Wang, Dan | Huang, Yuan | Luo, Chunyan | Li, Jia | Wang, Jingjing | Chen, Jing | Wang, Longfei | Wang, Li | Han, Meng | Ye, Jian | Chen, Feifei | Liu, Jingqiu | Liu, Ying | Wu, Gang | Yang, Bo | Cheng, Xiang | Liao, Yuhua | Wu, Yanxia | Ke, Tie | Chen, Qiuyun | Tu, Xin | Elston, Robert | Rao, Shaoqi | Yang, Yanzong | Xia, Yunlong | Wang, Qing K.\nPLoS Genetics 2015;11(8):e1005393.\nAtrial fibrillation (AF) is the most common cardiac arrhythmia at the clinic. Recent GWAS identified several variants associated with AF, but they account for <10% of heritability. Gene-gene interaction is assumed to account for a significant portion of missing heritability. Among GWAS loci for AF, only three were replicated in the Chinese Han population, including SNP rs2106261 (G/A substitution) in ZFHX3, rs2200733 (C/T substitution) near PITX2c, and rs3807989 (A/G substitution) in CAV1. Thus, we analyzed the interaction among these three AF loci. We demonstrated significant interaction between rs2106261 and rs2200733 in three independent populations and combined population with 2,020 cases/5,315 controls. Compared to non-risk genotype GGCC, two-locus risk genotype AATT showed the highest odds ratio in three independent populations and the combined population (OR=5.36 (95% CI 3.87-7.43), P=8.00×10-24). The OR of 5.36 for AATT was significantly higher than the combined OR of 3.31 for both GGTT and AACC, suggesting a synergistic interaction between rs2106261 and rs2200733. Relative excess risk due to interaction (RERI) analysis also revealed significant interaction between rs2106261 and rs2200733 when exposed two copies of risk alleles (RERI=2.87, P<1.00×10-4) or exposed to one additional copy of risk allele (RERI=1.29, P<1.00×10-4). The INTERSNP program identified significant genotypic interaction between rs2106261 and rs2200733 under an additive by additive model (OR=0.85, 95% CI: 0.74-0.97, P=0.02). Mechanistically, PITX2c negatively regulates expression of miR-1, which negatively regulates expression of ZFHX3, resulting in a positive regulation of ZFHX3 by PITX2c; ZFHX3 positively regulates expression of PITX2C, resulting in a cyclic loop of cross-regulation between ZFHX3 and PITX2c. Both ZFHX3 and PITX2c regulate expression of NPPA, TBX5 and NKX2.5. These results suggest that cyclic cross-regulation of gene expression is a molecular basis for gene-gene interactions involved in genetics of complex disease traits.\nGene-gene interaction is assumed to be critical to the pathogenesis of human disease, but its contribution to human disease phenotype needs definitive documentation. Moreover, the underlying molecular mechanism for gene-gene interaction is unknown. Here we use atrial fibrillation (AF) as a model to demonstrate that gene-gene interaction plays an important role in disease pathogenesis. Only three of the ten AF loci identified by GWAS in European ancestry populations, including PITX2c, ZFHX3, and CAV1, were replicated in the Chinese population and thus selected for gene-gene interaction studies. We show that the PITX2c locus interacts with the ZHFX3 locus to increase the risk of AF. Because gene-gene interaction can generate synergistic effect that markedly increases risk of AF, we conclude that gene-gene interaction accounts for a significant portion of heritability of AF. Mechanistically, PITX2c positively regulates ZHFX3 via miR-1 and ZHFX3 positively regulates PITX2c, which generates a loop of cross-regulation of the two genes. Our study suggests that cyclic cross-regulation of gene expression is a molecular basis for gene-gene interaction involved in disease phenotype.\n25. mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway Huang, Bin | Wang, Yongkui | Wang, Wenhao | Chen, Juan | Lai, Pinglin | Liu, Zhongyu | Yan, Bo | Xu, Song | Zhang, Zhongmin | Zeng, Chun | Rong, Limin | Liu, Bin | Cai, Daozhang | Jin, Dadi | Bai, Xiaochun\nPLoS Genetics 2015;11(8):e1005426.


url: =mode substrate i... (1)\nfolded half mode... (1)\nSubstrate integr... (1)\nIEEE MICROWAVE A...(2)\n1. A 13.5-19 GHz 20.6-dB Gain CMOS Power Amplifier for FMCW Radar Application SCOPUS SCIE EI\n2. Folded half mode substrate integrated waveguide 3 dB coupler SCIE\n作者：Zhai, GH; Hong, W; Wu, K; Chen, JX; Chen, P; Wei, J; Tang, HJ\n通讯作者地址：Zhai, GH (reprint author), SE Univ, Coll Informat Sci & Engn, State Key Lab Millimeter Waves, Nanjing 210096, Peoples R China.\n作者机构：[Zhai, Guo Hua; Hong, Wei; Chen, Ji Xin; Chen, Peng; Wei, Jing; Tang, Hong Jun] SE Univ, Coll Informat Sci & Engn, State Key Lab Millimeter Waves, Nan 更多[Zhai, Guo Hua; Hong, Wei; Chen, Ji Xin; Chen, Peng; Wei, Jing; Tang, Hong Jun] SE Univ, Coll Informat Sci & Engn, State Key Lab Millimeter Waves, Nanjing 210096, Peoples R China.; [Wu, Ke] Univ Montreal, Ecole Polytech, Dept Elect Engn, Poly Grames Res Ctr, Montreal, PQ H3C 3A7, Canada. 收起\n来源：IEEE MICROWAVE AND WIRELESS COMPONENTS LETTERS,2008,18,8,512-514


url: =BBC Online/BBC Online - Wanweipedia/wanweibaike\n^ "Internet Archive Wayback Machine". 29 October 1996. Archived from the original on 1 June 2002. Retrieved 1 October 2012. Cite uses generic title


url: =Proc. SPIE 1979, Impact of optical amplifiers on lightwave communications, 0000 (11 May 1993); doi: 10.1117/12.144076\nProc. SPIE 1979, High-average-power solid state lasers in multirod, slab, and tube configuration with improved beam quality, 0000 (11 May 1993); doi: 10.1117/12.144109\nBingKun Zhou; Qiming Wang; Lianhui Chen\nProc. SPIE 1979, Optoelectronic device research in China, 0000 (11 May 1993); doi: 10.1117/12.144120\nAvigdor Zajdman; Oded Amichai; N. Danon; Shai Eisenberg; Y. Kraus\nProc. SPIE 1979, ICCL: a novel industrial compact CO2 laser, 0000 (11 May 1993); doi: 10.1117/12.144131\nProc. SPIE 1979, Helical cascaded-metal-discs discharge tube fast-axial-flow CO2 laser, 0000 (11 May 1993); doi: 10.1117/12.144140\nProc. SPIE 1979, Recent developments in CO2 lasers, 0000 (11 May 1993); doi: 10.1117/12.144151\nProc. SPIE 1979, Characterization of high-power laser beams, 0000 (11 May 1993); doi: 10.1117/12.144160\nProc. SPIE 1979, Radiation processes and kinetics of the newly observed argon-fluoride and krypton-fluoride ionic excimers excited by laser-produced plasma, 0000 (11 May 1993); doi: 10.1117/12.144169\nHoward J. Baker; Denis R. Hall\nProc. SPIE 1979, High-power slab waveguide carbon dioxide lasers, 0000 (11 May 1993); doi: 10.1117/12.144179\nChengzhi Pan; Jingyuan Sun; Shipeng Yu\nProc. SPIE 1979, Microwave-excited slab-waveguide CO2 laser, 0000 (11 May 1993); doi: 10.1117/12.144087\nJianguo Xin; Er Jun Zang; Guang Hui Wei\nProc. SPIE 1979, rf-excited waveguide phase-coupled supermode-output CO2 laser, 0000 (11 May 1993); doi: 10.1117/12.144096\nTao Chen; Junlin Qiu; Xianjun Wong; Yihong Chen; Zhiwei Gong; Peifeng Chen; Zhong Tang; Qiyang Xu\nProc. SPIE 1979, Helium-free transverse-flow CO2 laser excited by high frequency, 0000 (11 May 1993); doi: 10.1117/12.144102\nProc. SPIE 1979, Influence of electrode materials on CO laser, 0000 (11 May 1993); doi: 10.1117/12.144103\nDounan Zhuang; Shizhan Lei; Rongkai Huang; Guiqiu Yu; Jinmin Ma\nProc. SPIE 1979, New ways for getting VUV/XUV lasers, 0000 (11 May 1993); doi: 10.1117/12.144104\nProc. SPIE 1979, Free-electron lasers with novel polarization states, 0000 (11 May 1993); doi: 10.1117/12.144105\nProc. SPIE 1979, Degradation of the superradiance power in an optical klystron and electron beam quality, 0000 (11 May 1993); doi: 10.1117/12.144106\nRichard W. Solarz; George F. Albrecht; Raymond J. Beach; Brian J. Comaskey\nProc. SPIE 1979, High-power diode-pumped solid state lasers, 0000 (11 May 1993); doi: 10.1117/12.144107\nJingwen Xu; Shiqun Li; Kotik Kei Lee; Ying-Chih Chen\nProc. SPIE 1979, Phase locking of a two-element laser array, 0000 (11 May 1993); doi: 10.1117/12.144108\nJiaze Li; Chunqing Gao; Guang Hui Wei; Minyan Yao\nProc. SPIE 1979, Experimental study on mode matching of LD end-pumped solid state lasers, 0000 (11 May 1993); doi: 10.1117/12.144110\nMali Gong; Feng Jin; Xi Lu; Zheng Wei Fu; Zuowen Wan\nProc. SPIE 1979, Highly efficient cw TEM00 Nd:YAG laser end-pumped by a laser diode, 0000 (11 May 1993); doi: 10.1117/12.144111\nYujing Huo; Dezhong Shen; Jinxing Cai; Xiaoyan Ma; BingKun Zhou; Aihua Zhang\nProc. SPIE 1979, Laser-diode-pumped Nd:YAG-KTP intracavity frequency-doubling laser and its transverse mode, 0000 (11 May 1993); doi: 10.1117/12.144112\nYujing Huo; Pu Wang; Hongbing Wu; Hengfu Pan; Jinxing Cai; Jing Xue; BingKun Zhou; Baoshing Lu\nProc. SPIE 1979, Diode-pumped self-doubling laser of modified neodymium-yttrium-aluminum-borate crystal, 0000 (11 May 1993); doi: 10.1117/12.144113\nYujing Huo; Gansheng Li; Jianbin He; Xibin Guo; BingKun Zhou\nProc. SPIE 1979, Laser-diode-pumped Nd:YVO4 lasers, 0000 (11 May 1993); doi: 10.1117/12.144114\nFuzheng Zhou; Jianwei Ma; Sanyou Zhu; Xiaohua Shen; Jun Xu; Guangmin Chen; Liqing Shen; Dianyuan Fan\nProc. SPIE 1979, Pulse compression of a Q-switched diode-laser-pumped Nd:YLF laser by gain switching, 0000 (11 May 1993); doi: 10.1117/12.144115\nProc. SPIE 1979, Cavity-modified spontaneous emission rate in Nd-glass microsphere, 0000 (11 May 1993); doi: 10.1117/12.144116\nJinxiong Wang; Dongsheng Jiang; Shouhuan Zhou\nProc. SPIE 1979, Investigation of beating-frequency measurement of laser axial modes, 0000 (11 May 1993); doi: 10.1117/12.144117\nHuang Fang; Huang Liu; Baolu Yin; Jinfeng Zhou\nProc. SPIE 1979, Autocontrolled intense LiB3O5 picosecond optical parametric generator, 0000 (11 May 1993); doi: 10.1117/12.144118\nMing Zhong; K. Han; F. Jin; Zhiming Yang; H. Han\nProc. SPIE 1979, Influences of lateral magnification and optical interval on the output of 1.54-um intracavity Raman laser, 0000 (11 May 1993); doi: 10.1117/12.144119\nNianchun Sun; Chong-Jun Deng; Yiping Li; Zhengxing Wang; Zhiming Yang; Baida Lu\nProc. SPIE 1979, Theoretical and experimental studies of resonators with variable reflectivity Fabry-Perot interferometer couplers, 0000 (11 May 1993); doi: 10.1117/12.144121\nZhizhan Xu; Pinzhong Fan\nProc. SPIE 1979, Recent results of recombination x-ray laser research at SIOFM, 0000 (11 May 1993); doi: 10.1117/12.144122\nKe Shen; Xidong Feng; Yongda Li; Shaohua Hou\nProc. SPIE 1979, Modes in an x-ray cavity, 0000 (11 May 1993); doi: 10.1117/12.144123\nLiying Han; Jiancun Gao; Jianchen Wang\nProc. SPIE 1979, Recent development of low-voltage reactive-ion-plating deposition of optical thin films in China, 0000 (11 May 1993); doi: 10.1117/12.144124\nYuanhua Shen; Xuantong Ying; Hang Xue; Zhongjing Xing; G. Q. Ke; K. T. Chen; Fengshan Zhang; Jianzhong Xu; ShiDe Ling;et. al.\nProc. SPIE 1979, Reducing the surface scattering of diamond optical thin films, 0000 (11 May 1993); doi: 10.1117/12.144125\nXin-Zhang Guo; Wan-Li Yin; Feng-Qin Yu\nProc. SPIE 1979, Ceramic metal-type selective absorptive film, 0000 (11 May 1993); doi: 10.1117/12.144126\nProc. SPIE 1979, Characteristics and development of tunable lasers of Ti:Al2O3, 0000 (11 May 1993); doi: 10.1117/12.144127\nBing Xu; Li-Huang Lin; Ouyang Bin; Qinguo Li; Xiaodong Yang; Runwen Wang\nProc. SPIE 1979, Experimental study of a gain-switched Ti:sapphire laser, 0000 (11 May 1993); doi: 10.1117/12.144128\nJianquan Yao; Xinglong Wang; Changqing Wang; Jingping Ning; Xiaojun Fang; Weidong Sheng\nProc. SPIE 1979, Experimental investigations and rate equations of quasi-continuous-wave laser operation of titanium-doped sapphire, 0000 (11 May 1993); doi: 10.1117/12.144129\nProc. SPIE 1979, Q-switched and mode-locked characteristics of NYAB crystal, 0000 (11 May 1993); doi: 10.1117/12.144130\nProc. SPIE 1979, Nd:YAG Q-switched laser with variable-reflectivity mirror resonator, 0000 (11 May 1993); doi: 10.1117/12.144132\nYiding Li; Dongsheng Jiang; Shouhuan Zhou\nProc. SPIE 1979, Computer simulation of the thermally induced birefringence in a high-repetition-rate Nd:YAG laser, 0000 (11 May 1993); doi: 10.1117/12.144133\nShaohe Chen; Tao-Lue Chen; Youming Chen; Guoping Sheng; Xiangdong Si; Xiaodong Guo; Jianqiang Zhu; Ximing Deng\nProc. SPIE 1979, Photoconductive switch applied in solid state lasers, 0000 (11 May 1993); doi: 10.1117/12.144134\nZhuhong Zhang; Dianyuan Fan; Ximing Deng\nProc. SPIE 1979, Pulse shortening and chirp production in a passively mode-locked Nd:YAG laser using GaAs, 0000 (11 May 1993); doi: 10.1117/12.144135\nGaoqiang Yuan; Xuanjun Jia; Yuyan Liu\nProc. SPIE 1979, Methane Raman laser with stimulated Raman scattering for Q-switching, 0000 (11 May 1993); doi: 10.1117/12.144136\nKunio Tada; Yoshiaki Nakano; Yi Luo\nProc. SPIE 1979, Gain-coupled DFB semiconductor lasers, 0000 (11 May 1993); doi: 10.1117/12.144137\nProc. SPIE 1979, High-performance gain-coupled distributed-feedback semiconductor lasers with absorptive gratings, 0000 (11 May 1993); doi: 10.1117/12.144138\nT. R. Chen; Bin Zhao; L. E. Eng; Y. H. Zhuang; Amnon Yariv\nProc. SPIE 1979, New achievements in ultralow-threshold semiconductor lasers, 0000 (11 May 1993); doi: 10.1117/12.144139\nBin Zhao; T. R. Chen; Yoshiro Yamada; Y. H. Zhuang; Amnon Yariv\nProc. SPIE 1979, Modulation and spectral dynamics in semiconductor quantum-well lasers, 0000 (11 May 1993); doi: 10.1117/12.144141\nQin Han; Rong Han Wu; Quanshen Zhang; Honghai Gao; Wen Gao\nProc. SPIE 1979, Light amplification and modulation in an InGaAsP/InP bistable laser, 0000 (11 May 1993); doi: 10.1117/12.144142\nNong Chen; Asanobu Kitamoto; Yoshiaki Nakano; Kunio Tada\nProc. SPIE 1979, Chirped-grating tunable DFB laser: novel laser diode with broader continuous tuning range, 0000 (11 May 1993); doi: 10.1117/12.144143\nProc. SPIE 1979, Dual-wavelength laser source with high stability, 0000 (11 May 1993); doi: 10.1117/12.144144\nKenji Ikeda; Satoshi Arimoto; Masao Aiga\nProc. SPIE 1979, High-power AlGaInP visible laser diodes with both multiquantum barrier and strain-induced active layer, 0000 (11 May 1993); doi: 10.1117/12.144145\nProc. SPIE 1979, Theoretical study of optical properties of strained-layer heterostructures, 0000 (11 May 1993); doi: 10.1117/12.144146\nProc. SPIE 1979, Quaternary laser devices: history and state of the art, 0000 (11 May 1993); doi: 10.1117/12.144147\nMin-Shyong Lin; GouChung Chi\nProc. SPIE 1979, R&D on optoelectronics at OES/ITRI, 0000 (11 May 1993); doi: 10.1117/12.144148\nProc. SPIE 1979, Frequency tracking and locking of diode laser using transmission spectrum of a Faraday anomalous-dispersion optical filter, 0000 (11 May 1993); doi: 10.1117/12.144149


url: =Home China (Mainland)Chengdu Haochuan Rubber And Plastic Co., Ltd.\nAddress: Community 6, Huanghua Village, Dafeng, Xindu Dist., Chengdu, Sichuan, China (Mainland).\nProducts/Services: silicone, rubber product\nChengdu Haochuan Rubber And Plastic Co., Ltd. Was established in October 2006, is a professional production of various rubber products and rubber materials fully meet customer for heat resistant, oil resistant, compression, acid and alkali resistance, abrasion resistance, weather resistance, tensile, tearing resistance, flame retardant, shock, cold, electric insulation, radiation resistance, low permeability and other physical properties.Products are widely applied in electronics, electrical appliances, communications equipment, computers, toys, audio and video equipment, sporting goods, health, medical equipment, and machinery manufacturing and other industries use.\nBusiness philosophy: people-oriented, science and technology is popular the factory, strive for perfection, the pursuit of excellence.\nShandong Yuwang Hetianxia New Materials Co., Ltd. 13 February, 2018 Products/Services: cyanoacrylate adhesive,super glue,anaerobic adhesive\nBussiness Type: manufacturer, trading company Year Established: 2015 Website: yuwangcn.com\nShanghai Heya Decoration Material Co., Ltd. 14 February, 2018 Products/Services: Caulk Strip,Door bottom sweep,Foam weather stripping,PU foam door seal,TPE or Silicone Rubber weather stripping\nBussiness Type: manufacturer, trading company Year Established: 2017 Website: weatherstrippingchina.com\nShantou City Huachun Hot Melt Adhesive Co., Ltd. 14 February, 2018 Products/Services: Hot melt glue stick,Bookbinding Hot Melt Adhesive,HOT melt adhesive particle,PSA Hot Melt,Furniture and Edge Binding Adhesive\nBussiness Type: trading company Year Established: 2013 Website: sthuachun.com/en\nLiaoning Shuangqiang Plastic Industry Develop Co., Ltd. 11 February, 2018 Products/Services: insulating glass spacer,alumminium spacer,hot melt sealant,butyl sealant,sealing spacer for IG\nBussiness Type: manufacturer, trading company Year Established: 2007 Website: shuangguan.net/EN\nShanghai Haohai Chemical Co., Ltd. 11 February, 2018 Products/Services: Aerosol Products,Makeup,Pre-insulated Duct Panel,Chemical Raw Material\nBussiness Type: manufacturer, trading company Year Established: 2000 Website: haohaigroup.com\nDongguan Techs-cool Advanced Materials Co., Ltd. 14 February, 2018 Products/Services: PI thermal conductive double-sided adhesive,PET thermal conductive double-sided adhesive,no substrate thermal conductive double-sided adhesive,Copper foil thermal conductive double-sided adhesive,Aluminum foil thermal conductive double-sided adhesive\nBussiness Type: manufacturer, trading company Year Established: 2017 Website: techs-cool.com.cn\nAnshan Boyuan Airproof Material Company Ltd. 13 February, 2018 Products/Services: Tire Seal,Patch Plug,tire repair string,mushroom patch\nBussiness Type: manufacturer, trading company Year Established: 2011 Website: asboyuan.com asboyuan.cn\nQingdao Kingway Construction Co., Ltd. 11 February, 2018 Products/Services: AAC Wall Panel,Gypsum Board,PVC Laminated Gypsum Ceiling Board,AAC Block,Decoration Gypsum Ceiling Board\nBussiness Type: trading company Year Established: 2009 Website: kingwaytrading.com.cn kingwayaac.com gypsumplate.com\nGuangzhou Banyu Communication Technology Co., Ltd. 12 February, 2018 Products/Services: Mobile phone accessories,Touch screen,mobile phone cases\nBussiness Type: trading company Year Established: 2012 Website: bayu.en.alibaba.com\nHangzhou Ren He Hot Melt Adhesive Co., Ltd. 13 February, 2018 Products/Services: Hot Melt Adhesive Used in Shoes,Hot Melt Adhesive Used in Package,Hot Melt Adhesive Used in Others\nBussiness Type: manufacturer Year Established: 2000 Website: hm-adhesive.com


url: =Clinical study of Chinese proprietary combined with lamivudine in hepatic fibrosis with chronic hepatitis B--《Chinese Journal of Difficult and Complicated Cases》2013年01期\nClinical study of Chinese proprietary combined with lamivudine in hepatic fibrosis with chronic hepatitis B\nZHANG Zhuo,GONG Jia-bin,LIU Ya-li.Department of Integrated TCM and Western Medicine,Suizhou Central Hospital of Hubei Province,Suizhou 441300,China\nObjective To study the clinical effects of combined treatment about traditional Chinese medicine and western medicine in hepatic fibrosis(HF)with chronic hepatitis B(CHB).Methods 90 patients with CHB were randomly divided into observation group(n=45)and control group(n=45),control group were treated with western medicine,and observation group were treated with integrated traditional Chinese and western medicine.Then liver function,CHB virological indicators,and HF serum marker changes before and after treatment were compared between the two groups.Results After the treatment,liver function,CHB virological indicators,and HF serum marker were significantly better than before both in the two groups(P 0.05,P 0.01),and observation group were significantly better than control group after the treatment (P 0.01 or P 0.05).Conclusion Combined treatment of traditional Chinese medicine and western medicine has good effects in HF with CHB,but the long term effects are unclear,and further research is needed to confirm it.\n1 TIAN Fei;LI Lan;TANG Gang-xue;ZHANG Yi;Tongren Center for Disease Control and Prevention;;Analysis on surveillance results of hepatitis B antibody level of healthy people in Tongren city in 2014[J];中国当代医药;2015-25\n2 WANG Chuanmin;KE Changzheng;ZHANG Yinhua;MENG Zhongji;Shiyan Taihe Hospital Affiliated to Hubei Medical College;;Influence of Fuzheng Huayu Capsule combined with Adefovir Dipivoxil Tablets on liver function and liver fibrosis of patient with chronic hepatitis B[J];现代中西医结合杂志;2015-15\n3 Luo Junhua;Wang Linqun;Cao Qiushi;Wuhan General Hospital of Guangzhou Military Command of PLA;Hubei University of TCM;;Effect of entecavir combined with Diwu Yanggan anagraph in treatment of hepatitis B virus associated nephritis and its influence on IL-2 and IFN-γ[J];现代中西医结合杂志;2014-21\n1 LIU Hongfang 1,2 LIN Xiaofeng 1,2 XU Luli 1,2 CHENG Zhiyun 1,2 LV Yinghui 1,2 1.Institute of Molecular Medicine, Huaqiao University, Quanzhou 362021, China; 2.Molecular Medicine Engineering Research Center, Quanzhou 362021,China;Progress in development of anti-hepatic fibrosis drug[J];中国医药科学;2011-20\n2 CAO Xin-xian,LI Jia,QIU Long-min,LUO Ya-wen,CHEN Ying-hua,RAN Yan Department of Infectious Diseases,The Affiliated Hospital of Zunyi Medical College,Zunyi 563003,China;Identification of factors associated with YMDD mutation in patients with chronic hepatitis B receiving lamivudine treatment[J];中华肝脏病杂志;2009-09\n3 FU Yue-xiao1,GU Can-li1,JIAO Wei2(1.The People's Hospital of Ruyang,Ruyang 471200,Henan,China;2.Institute of Traditional Chinese Medicine,Zhengzhou 450003,Henan,China);Conbined Treatment of Traditional Chinese Medicine and Western Medicine Treat Therapeutie Effect of the Chronic Hepatic Fibros is of Type B Hepatitis[J];中华中医药学刊;2007-02\n1 YE Wei;XU Liu-wan;YAN Ren-jie;XU Wei-jun;Department of Mechanical & Electrical Engineering, Lanzhou Jiaotong University;;Research Progress in Nickel Coating on Carbon Fiber[J];科技视界;2015-13\n2 Lu Xiang;Yao Junping;Sun Zhong;School of Aeronautic and Mechanical Engineering,Nanchang Hangkong University;;Simulation of Effects of In-situ Mg_2Si Particles Distribution on Stress Field Distribution in Magnesium Matrix[J];特种铸造及有色合金;2015-01\n3 CHEN Su-juan;ZHANG Rui-ying;SHI Zhi-ming;LI Yan-hui;HAN Xiao-wei;School of Materials Science and Engineering,Inner Mongolia University of Technology;Key Laboratory of Light Metal Materials;;Effect of La on microstructure and corrosion resistance of in-situ synthesized TiC-Al_2O_3/Al composites[J];材料热处理学报;2014-11\n4 WANG Junjie;Department of Mechanical Engineering, Zhengzhou Technical College;;Application of Stirring Casting Method on Preparation of SiC_p/Al Composite Material[J];热加工工艺;2014-19\n5 ZHANG Liang;WANG Zhenjun;SHANG Hongfu;ZHU Shixue;National Defence Key Discipline Laboratory of Light Alloy Processing Science and Technology, Nanchang Hangkong University;;Hot Compression Behaviors of C_(sf)/Mg Composite and Its Constitutive Relation[J];热加工工艺;2014-18\n6 CHENG Tao;JIA Jian-gang;MA Qin;JI Gen-shun;GUO Tie-ming;State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals,Lanzhou University of Technology;Key Laboratory of Non-ferrous Metal Alloys,The Ministry of Education,Lanzhou University of Technology;;Deposition of homogeneous copper layer on short carbon fibers using electrochemical method[J];材料热处理学报;2014-09\n7 Xiao Ronglin;Zheng Hua'an;Fu Dongsheng;Li Yingping;Yang Yang;Hu Guohe;Lü Xiaoli;State Key Laboratory of Clean and Grading Conversion,Shaanxi Coal and Chemical Technology Institute Co.,Ltd.;;Progress in Several Key Problems of Magnesium Matrix Composites Reinforced with Carbon Nanotubes[J];特种铸造及有色合金;2014-09\n8 ZHUANG Yan;CHEN Jingchao;CHENG Jin;MENG Xuan;YANG Bo;Key Laboratory of Advance Material of Rare Precious and Nonferrous Metals, Education Ministry of China, Kunming University of Science and Technology;;Review of Carbon Fiber's Surface Modification[J];热加工工艺;2014-16\n9 TAN Xun-yan;ZHA Li-xia;XIA Guang-hua;LI Xiao-hong;LIAO Wen-chuan;ZHU Xiao-xin;School of Materials Science and Engineering,Jingdezhen Ceramic Institute;;Influence of Rare Earth on the Properties of Al_2O_3-TiC/Fe Based Metal Ceramic Materials[J];人工晶体学报;2014-05\n10 Huang Mingfu;Wu Jicai;Liu Yong;Zeng Xiaoshu;(Yugan)Forging Co.Ltd of Jiangxi Copper Corporation;School of Mechanical-electrical Engineering,Nanchang University;;Effects of Carbon Nanotube on Die Casting ZM5 Magnesium Matrix Composites[J];特种铸造及有色合金;2014-03\n1 LAI Li-na1,YANG Liu-xu2,GUO Chun-hua1,ZHANG Xiao-yi1,WANG Li-min3,FAN Yi-min3(1.Dept of Pharmacology,2.Institute of Hepatology,3.Functional Lab of Medicine, Changzhi Medical College,Changzhi Shanxi 046000,China);Effects and mechanisms of artesunate on immunological hepatic fibrosis in experimental rats[J];中国药理学通报;2011-01\n2 WU Li,ZHENG Shi-zhong,PAN Su-hua,LU Yin(College of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210046,China);Effect of immunocytes on the process of hepatic fibrosis[J];中国药理学通报;2010-12\n3 LIU Ye~1,QI Li-hong~1, WANG Shuo-feng~2, ZHANG Yue-fan~2, GUI Min~2, ZHANG Min~2, ZHANG Jun-ping~2(1. Department of Pharmacy, Fuzhou General Hospital, PLA Nanjing Military Area Command,Fuzhou 350001; 2. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China);Establishment of a liver fibrosis model in vitro by hepatic stellate HSC-T6 cells[J];药学实践杂志;2005-06\n4 WANG Yi-guang, ZHU Wu-jun, YANG Xing-lin.Central Laboratory, the Fifth People's Hospital, Guiyang 550004, China;Investigation of the relationships between HBV YMDD variation and its genotypes[J];中华肝脏病杂志;2005-03\n5 ZHOU Jian-liang, WU Shi-pin. Department of Infectious Diseases, Shenzhen People's Hospital, Jinan University Medical School, Shenzhen 518020, China;Effects comparison of lamivudine therapy for hepatitis B virus genotypes B and C[J];中华肝脏病杂志;2004-08\n6 JIANG Chunmeng, LIU Chenghai, LIU Cheng Institute of Liver Diseases, Shanghai University of TCM, Shanghai 200032;Inhibiting Effect of Fuzhenghuayu Capsule on the Activation of Hepatic Stellate Cells in Rats[J];中国中西医结合消化杂志;2003-05\n7 Yao Jilu Gao Zhiliang Peng Xiaomao Zhou Yanping Li Gang Chong Yutian Deng Zhide He Youcheng Ke Weiming Lu Weilun (Hepatitis Institute, Depatment of Infectious Diseases, The Third Affiliated Hospital, Sun Yat sen University of Medical Scien;Basis and Applied Study of Clinical Diagnosis and Treatment on Viral Hepatitis[J];中山医科大学学报;1999-01