url: =Experimental Study on CO_2 Huff & Puff in Waterflooding Heavy Oil Reservoirs--《Journal of Chengde Petroleum College》2006年04期\n《Journal of Chengde Petroleum College》 2006-04\nExperimental Study on CO_2 Huff & Puff in Waterflooding Heavy Oil Reservoirs\nWU Yong-bin~1,QI Shi-long~2(1.Research Institute of Petroleum Exploration and Development,Petrochina,Beijing 100083,China;2.Research Institute of Oil Production Engineering,Daqing Oil Company,Petrochina,Daqing 163000,Heilongjiang,China)\nIn order to further enhance the production performance of conventional water-flooding heavy oil reservoirs,in-house experimental approach is conducted to study the mechanism and feasibility of CO_2 huff puff after water flooding and the recovery parameters affecting the production performance of CO_2 huff puff.The experiment result shows that cyclic gas injection,injection rate,shut-in time,bottom hole pressure and patterns of pressure release all influence the production performance of CO_2 huff puff;and good effect can be received by properly controlling the recovery parameters listed above.\n1 OU Jin1, LIU Xue-wei2, HE Ying-fu2, ZHANG Ying-xia3, LIU Li2 ( 1. School of Energy Resources, China University of Geosciences, Beijing 100083, China; 2. Institute of Porous Flow & Fluid Mechanics, CNPC, Langfang, Hebei 065007, China; 3. Research Institute of Development and Exploration, North China Oilfield Company, Renqiu, Hebei 062552, China );Effect of CO_2 stimulation on the exploitation of Samaa heavy oil reservoir in Sudan[J];Journal of Daqing Petroleum Institute;2007-02\n2 Wu Yongbin~1 Qi Shilong~2 1.Research Institute of Oil & Gas Exploration and Development,CNPC,Beijing100083,China; 2.Research Institute of Oil Production Engineering of Daqing Oil Field,CNPC,Daqing163453,Heilongjiang Province,China;STUDIES ON TRANSITION FROM WATER DRIVE TO CO~2 SOAK FOR COMMON HEAVY OIL[J];Southern China Oil & Gas;2006-Z1


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url: =WO2020114394 VIDEO ENCODING/DECODING METHOD, VIDEO ENCODER, AND VIDEO DECODER\n1. WO2020114394 - VIDEO ENCODING/DECODING METHOD, VIDEO ENCODER, AND VIDEO DECODER\nPublication Number WO/2020/114394\nInternational Application No. PCT/CN2019/122710


url: =Pharmacognosy Magazine (5)\nJin, Xin (134)\nBei, Jin-Xin (27)\nZeng, Yi-Xin (24)\nFeng, Qi-Sheng (14)\nChen, Li-Zhen (13)\nLi, Yingrui (10)\nCui, Ningren (6)\nJia, Wei-Hua (6)\nChang, Hui (5)\nCosta, Rui M. (5)\nLiu, Wen-Sheng (5)\nTian, Chong (5)\nWang, Ningli (5)\nYe, Xiaolei (5)\nYing, Chenjiang (5)\nZhang, Ting (5)\nZhang, Zhen-hai (5)\nCao, Dandan (4)\nChen, Ming-Yuan (4)\nCui, Qian (4)\nDing, Shibin (4)\nFoo, Jia Nee (4)\nGuo, Yun-Miao (4)\nJia, Xiao-bin (4)\nLin, Zhongxu (4)\nMo, Hao-Yuan (4)\nOzaki, Mineo (4)\nRen, Jingjing (4)\nSun, Liangdan (4)\nTang, Bao-Peng (4)\nVithana, Eranga N. (4)\n1. Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians Cheng, Ching-Yu | Yamashiro, Kenji | Jia Chen, Li | Ahn, Jeeyun | Huang, Lulin | Huang, Lvzhen | Cheung, Chui Ming G. | Miyake, Masahiro | Cackett, Peter D. | Yeo, Ian Y. | Laude, Augustinus | Mathur, Ranjana | Pang, Junxiong | Sim, Kar Seng | Koh, Adrian H. | Chen, Peng | Lee, Shu Yen | Wong, Doric | Chan, Choi Mun | Loh, Boon Kwang | Sun, Yaoyao | Davila, Sonia | Nakata, Isao | Nakanishi, Hideo | Akagi-Kurashige, Yumiko | Gotoh, Norimoto | Tsujikawa, Akitaka | Matsuda, Fumihiko | Mori, Keisuke | Yoneya, Shin | Sakurada, Yoichi | Iijima, Hiroyuki | Iida, Tomohiro | Honda, Shigeru | Lai, Timothy Yuk Yau | Tam, Pancy Oi Sin | Chen, Haoyu | Tang, Shibo | Ding, Xiaoyan | Wen, Feng | Lu, Fang | Zhang, Xiongze | Shi, Yi | Zhao, Peiquan | Zhao, Bowen | Sang, Jinghong | Gong, Bo | Dorajoo, Rajkumar | Yuan, Jian-Min | Koh, Woon-Puay | van Dam, Rob M. | Friedlander, Yechiel | Lin, Yin | Hibberd, Martin L. | Foo, Jia Nee | Wang, Ningli | Wong, Chang Hua | Tan, Gavin S. | Park, Sang Jun | Bhargava, Mayuri | Gopal, Lingam | Naing, Thet | Liao, Jiemin | Ong, Peng Guan | Mitchell, Paul | Zhou, Peng | Xie, Xuefeng | Liang, Jinlong | Mei, Junpu | Jin, Xin | Saw, Seang-Mei | Ozaki, Mineo | Mizoguchi, Takinori | Kurimoto, Yasuo | Woo, Se Joon | Chung, Hum | Yu, Hyeong-Gon | Shin, Joo Young | Park, Dong Ho | Kim, In Taek | Chang, Woohyok | Sagong, Min | Lee, Sang-Joon | Kim, Hyun Woong | Lee, Ji Eun | Li, Yi | Liu, Jianjun | Teo, Yik Ying | Heng, Chew Kiat | Lim, Tock Han | Yang, Suk-Kyun | Song, Kyuyoung | Vithana, Eranga N. | Aung, Tin | Bei, Jin Xin | Zeng, Yi Xin | Tai, E. Shyong | Li, Xiao Xin | Yang, Zhenglin | Park, Kyu-Hyung | Pang, Chi Pui | Yoshimura, Nagahisa | Wong, Tien Yin | Khor, Chiea Chuen\n2. New loci and coding variants confer risk for age-related macular degeneration in East Asians Cheng, Ching-Yu | Yamashiro, Kenji | Jia Chen, Li | Ahn, Jeeyun | Huang, Lulin | Huang, Lvzhen | Cheung, Chui Ming G. | Miyake, Masahiro | Cackett, Peter D. | Yeo, Ian Y. | Laude, Augustinus | Mathur, Ranjana | Pang, Junxiong | Sim, Kar Seng | Koh, Adrian H. | Chen, Peng | Lee, Shu Yen | Wong, Doric | Chan, Choi Mun | Loh, Boon Kwang | Sun, Yaoyao | Davila, Sonia | Nakata, Isao | Nakanishi, Hideo | Akagi-Kurashige, Yumiko | Gotoh, Norimoto | Tsujikawa, Akitaka | Matsuda, Fumihiko | Mori, Keisuke | Yoneya, Shin | Sakurada, Yoichi | Iijima, Hiroyuki | Iida, Tomohiro | Honda, Shigeru | Lai, Timothy Yuk Yau | Tam, Pancy Oi Sin | Chen, Haoyu | Tang, Shibo | Ding, Xiaoyan | Wen, Feng | Lu, Fang | Zhang, Xiongze | Shi, Yi | Zhao, Peiquan | Zhao, Bowen | Sang, Jinghong | Gong, Bo | Dorajoo, Rajkumar | Yuan, Jian-Min | Koh, Woon-Puay | van Dam, Rob M. | Friedlander, Yechiel | Lin, Ying | Hibberd, Martin L. | Foo, Jia Nee | Wang, Ningli | Wong, Chang Hua | Tan, Gavin S. | Park, Sang Jun | Bhargava, Mayuri | Gopal, Lingam | Naing, Thet | Liao, Jiemin | Guan Ong, Peng | Mitchell, Paul | Zhou, Peng | Xie, Xuefeng | Liang, Jinlong | Mei, Junpu | Jin, Xin | Saw, Seang-Mei | Ozaki, Mineo | Mizoguchi, Takanori | Kurimoto, Yasuo | Woo, Se Joon | Chung, Hum | Yu, Hyeong-Gon | Shin, Joo Young | Park, Dong Ho | Kim, In Taek | Chang, Woohyok | Sagong, Min | Lee, Sang-Joon | Kim, Hyun Woong | Lee, Ji Eun | Li, Yi | Liu, Jianjun | Teo, Yik Ying | Heng, Chew Kiat | Lim, Tock Han | Yang, Suk-Kyun | Song, Kyuyoung | Vithana, Eranga N. | Aung, Tin | Bei, Jin Xin | Zeng, Yi Xin | Tai, E. Shyong | Li, Xiao Xin | Yang, Zhenglin | Park, Kyu-Hyung | Pang, Chi Pui | Yoshimura, Nagahisa | Yin Wong, Tien | Khor, Chiea Chuen\n3. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer Chen, Qing | Boire, Adrienne | Jin, Xin | Valiente, Manuel | Er, Ekrem Emrah | Lopez-Soto, Alejandro | Jacob, Leni | Patwa, Ruzeen | Shah, Hardik | Xu, Ke | Cross, Justin R. | Massagué, Joan\nBrain metastasis represents a substantial source of morbidity and mortality in various cancers, and is characterized by high resistance to chemotherapy. Here we define the role of the most abundant cell type in the brain, the astrocyte, in promoting brain metastasis. Breast and lung cancer cells express protocadherin 7 (PCDH7) to favor the assembly of carcinoma-astrocyte gap junctions composed of connexin 43 (Cx43). Once engaged with the astrocyte gap-junctional network, brain metastatic cancer cells employ these channels to transfer the second messenger cGAMP to astrocytes, activating the STING pathway and production of inflammatory cytokines IFNα and TNFα. As paracrine signals, these factors activate the STAT1 and NF-κB pathways in brain metastatic cells, which support tumour growth and chemoresistance. The orally bioavailable modulators of gap junctions meclofenamate and tonabersat break this paracrine loop, and we provide proof-of-principle for the applicability of this therapeutic strategy to treat established brain metastasis.\n4. Propagation of homeostatic sleep signals by segregated synaptic microcircuits of the Drosophila mushroom body Sitaraman, Divya | Aso, Yoshinori | Jin, Xin | Chen, Nan | Felix, Mario | Rubin, Gerald M. | Nitabach, Michael N.\nCurrent biology : CB 2015;25(22):2915-2927.\nThe Drosophila mushroom body (MB) is a key associative memory center that has also been implicated in the control of sleep. However, the identity of MB neurons underlying homeostatic sleep regulation, as well as the types of sleep signals generated by specific classes of MB neurons, has remained poorly understood. We recently identified two MB output neuron (MBON) classes whose axons convey sleep control signals from the MB to converge in the same downstream target region: a cholinergic sleep-promoting MBON class and a glutamatergic wake-promoting MBON class. Here we deploy a combination of neurogenetic, behavioral, and physiological approaches to identify and mechanistically dissect sleep-controlling circuits of the MB. Our studies reveal the existence of two segregated excitatory synaptic microcircuits that propagate homeostatic sleep information from different populations of intrinsic MB “Kenyon cells” (KCs) to specific sleep-regulating MBONs: sleep-promoting KCs increase sleep by preferentially activating the cholinergic MBONs, while wake-promoting KCs decrease sleep by preferentially activating the glutamatergic MBONs. Importantly, activity of the sleep-promoting MB microcircuit is increased by sleep deprivation and is necessary for homeostatic rebound sleep (i.e., the increased sleep that occurs after, and in compensation for, sleep lost during deprivation). These studies reveal for the first time specific functional connections between subsets of KCs and particular MBONs and establish the identity of synaptic microcircuits underlying transmission of homeostatic sleep signals in the MB.\n5. Patterns of CRISPR/Cas9 activity in plants, animals and microbes Bortesi, Luisa | Zhu, Changfu | Zischewski, Julia | Perez, Lucia | Bassié, Ludovic | Nadi, Riad | Forni, Giobbe | Lade, Sarah Boyd | Soto, Erika | Jin, Xin | Medina, Vicente | Villorbina, Gemma | Muñoz, Pilar | Farré, Gemma | Fischer, Rainer | Twyman, Richard M. | Capell, Teresa | Christou, Paul | Schillberg, Stefan\nPlant Biotechnology Journal 2016;14(12):2203-2216.\nThe CRISPR/Cas9 system and related RNA‐guided endonucleases can introduce double‐strand breaks (DSBs) at specific sites in the genome, allowing the generation of targeted mutations in one or more genes as well as more complex genomic rearrangements. Modifications of the canonical CRISPR/Cas9 system from Streptococcus pyogenes and the introduction of related systems from other bacteria have increased the diversity of genomic sites that can be targeted, providing greater control over the resolution of DSBs, the targeting efficiency (frequency of on‐target mutations), the targeting accuracy (likelihood of off‐target mutations) and the type of mutations that are induced. Although much is now known about the principles of CRISPR/Cas9 genome editing, the likelihood of different outcomes is species‐dependent and there have been few comparative studies looking at the basis of such diversity. Here we critically analyse the activity of CRISPR/Cas9 and related systems in different plant species and compare the outcomes in animals and microbes to draw broad conclusions about the design principles required for effective genome editing in different organisms. These principles will be important for the commercial development of crops, farm animals, animal disease models and novel microbial strains using CRISPR/Cas9 and other genome‐editing tools.\ngenome editing; mutational signature; off‐target mutations; on‐target mutations; sgRNA design; site‐directed mutagenesis; species‐dependent effects\n6. Effect of Femoral Resection on Coronal Overall Alignment after Conventional Total Knee Arthroplasty Zhao, Min-Wei | Wang, Lu | Zeng, Lin | Hu, Yu-Qing | Hu, Jin-Xin | Tian, Hua\nChinese Medical Journal 2016;129(21):2535-2539.\nA good postoperative alignment in total knee arthroplasty (TKA) is the key to achieving satisfactory results. We assessed the effect of femoral and tibial resection on the overall alignment after conventional TKA.\nWe conducted a retrospective analysis of 212 primary TKAs in 188 patients. Intramedullary (IM)-guided resection was applied on the femoral side while extramedullary (EM)-guided resection was used on the tibial side. Using full-length X-ray, the preoperative femoral valgus angle and lower extremity alignment, as well as 2-week postoperative femoral and tibial prosthetic coronal alignment and overall lower extremity alignment, were measured.\nPostoperatively, good prosthetic alignment was achieved in 191 cases (90.1%) on the tibial side and in 144 cases (67.9%) on the femoral side (χ2 = 5.441, P = 0.02). Multiple linear regression analysis was used to assess the effect of different alignment sides on the overall alignment in the coronal plane. Data were divided into five subgroups based on the valgus or varus status of the prostheses. The standardized regression coefficients of the femoral and tibial prosthetic alignment on the overall alignment were 0.666 and 0.414, respectively; in varus on both sides were 0.658 and 0.377, respectively; in valgus, 0.555 and 0.030; femoral side varus and tibial side valgus, 0.702 and 0.211; femoral side valgus and tibial side varus, −0.416 and 0.287. The study showed that the overall low extremity alignment was statistically influenced by the prosthetic alignment, except for the tibial prosthetic alignment when femoral prosthesis was in valgus (P = 0.153).\nIn conventional TKA, tibial side EM-guided resection may offer satisfactory postoperative alignment, and femoral resection relying on IM guide may lead to more undesirable results. Postoperative coronal alignment is mainly affected by the femoral resection. Therefore, femoral side operation should receive adequate attention from the surgeons.\n7. Blockade of PD-1 Signaling Enhances Th2 Cell Responses and Aggravates Liver Immunopathology in Mice with Schistosomiasis japonica Zhou, Sha | Jin, Xin | Li, Yalin | Li, Wei | Chen, Xiaojun | Xu, Lei | Zhu, Jifeng | Xu, Zhipeng | Zhang, Yang | Liu, Feng | Su, Chuan\nPLoS Neglected Tropical Diseases 2016;10(10):e0005094.\nMore than 220 million people worldwide are chronically infected with schistosomes, causing severe disease or even death. The major pathological damage occurring in schistosomiasis is attributable to the granulomatous inflammatory response and liver fibrosis induced by schistosome eggs. The inflammatory response is tightly controlled and parallels immunosuppressive regulation, constantly maintaining immune homeostasis and limiting excessive immunopathologic damage in important host organs. It is well known that the activation of programmed death 1 (PD-1) signaling causes a significant suppression of T cell function. However, the roles of PD-1 signaling in modulating CD4+ T cell responses and immunopathology during schistosome infection, have yet to be defined.\nHere, we show that PD-1 is upregulated in CD4+ T cells in Schistosoma japonicum (S. japonicum)-infected patients. We also show the upregulation of PD-1 expression in CD4+ T cells in the spleens, mesenteric lymph nodes, and livers of mice with S. japonicum infection. Finally, we found that the blockade of PD-1 signaling enhanced CD4+ T helper 2 (Th2) cell responses and led to more severe liver immunopathology in mice with S. japonicum infection, without a reduction of egg production or deposition in the host liver.\nOverall, our study suggests that PD-1 signaling is specifically induced to control Th2-associated inflammatory responses during schistosome infection and is beneficial to the development of PD-1-based control of liver immunopathology.\nSchistosomiasis is a parasitic disease that affects approximately 220 million people and causes serious morbidity and economic problems mainly in (sub)tropical regions. After Schistosoma japonicum or Schistosoma mansoni infection, parasite eggs are trapped in host liver and induce liver inflammation and fibrosis, leading to irreversible impairment of the liver, and even death of the host. Meanwhile, schistosomes also induce strong regulatory mechanisms to suppress inflammation and prevent excessive immunopathology. Considering it is well known that PD-1 plays a critical role in suppressing T cell function, understanding the role of PD-1 in modulating immune responses during schistosome infection is necessary for the development of PD-1-based control of liver damage in schistosomiasis. Here, increased PD-1 expression in CD4+ T cells from both humans and mice with schistosome infection was shown. We further showed that PD-1 blockade preferentially augmented Th2 cell responses and ultimately resulted in more severe liver immunopathology in mice with Schistosomiasis japonica, suggesting that PD-1 signaling is beneficial to further explore therapeutic possibilities for preventing the excessive liver immunopathology.\n8. Biomechanical Responses of the Brain in Swine Subject to Free-Field Blasts Feng, Ke | Zhang, Liying | Jin, Xin | Chen, Chaoyang | Kallakuri, Srinivasu | Saif, Tal | Cavanaugh, John | King, Albert\nFrontiers in Neurology 2016;7:179.\nBlast-induced traumatic brain injury (bTBI) is a signature wound of modern warfare. The current incomplete understanding of its injury mechanism impedes the development of strategies for effective protection of bTBI. Despite a considerable amount of experimental animal studies focused on the evaluation of brain neurotrauma caused by blast exposure, there is very limited knowledge on the biomechanical responses of the gyrenecephalic brain subjected to primary free-field blast waves imposed in vivo. This study aims to evaluate the external and internal mechanical responses of the brain against different levels of blast loading with Yucatan swine in free field. The incident overpressure (IOP) was generated using 3.6 kg of C4 charge placed at three standoff distances from the swine. Five swine were exposed to a total of 19 blasts. The three average peak IOP pressure levels in this study were 148.8, 278.9, and 409.2 kPa as measured by a pencil probe. The duration of the first positive wave was in the range of 2.1–3 ms. Pressure changes in the brain and head kinematics were recorded with intracranial pressure (ICP) sensors, linear accelerometers, and angular rate sensors. The corresponding average peak ICPs were in the range of 79–143, 210–281, and 311–414 kPa designated as low, medium, and high blast level, respectively. Peak head linear accelerations were in the range of 120–412 g. A positive correlation between IOP and its corresponding biomechanical responses of the brain was also observed. These experimental data can be used to validate computer models of bTBI.\nfree-field blast; head kinematics; traumatic brain injury; swine; intracranial pressure\n9. Purification and Characterization of a Novel Cold Shock Protein-Like Bacteriocin Synthesized by Bacillus thuringiensis Huang, Tianpei | Zhang, Xiaojuan | Pan, Jieru | Su, Xiaoyu | Jin, Xin | Guan, Xiong\nScientific Reports 2016;6:35560.\nBacillus thuringiensis (Bt), one of the most successful biopesticides, may expand its potential by producing bacteriocins (thuricins). The aim of this study was to investigate the antimicrobial potential of a novel Bt bacteriocin, thuricin BtCspB, produced by Bt BRC-ZYR2. The results showed that this bacteriocin has a high similarity with cold-shock protein B (CspB). BtCspB lost its activity after proteinase K treatment; however it was active at 60 °C for 30 min and was stable in the pH range 5–7. The partial loss of activity after the treatments of lipase II and catalase were likely due to the change in BtCspB structure and the partial degradation of BtCspB, respectively. The loss of activity at high temperatures and the activity variation at different pHs were not due to degradation or large conformational change. BtCspB did not inhibit four probiotics. It was only active against B. cereus strains 0938 and ATCC 10987 with MIC values of 3.125 μg/mL and 0.781 μg/mL, and MBC values of 12.5 μg/mL and 6.25 μg/mL, respectively. Taken together, these results provide new insights into a novel cold shock protein-like bacteriocin, BtCspB, which displayed promise for its use in food preservation and treatment of B. cereus-associated diseases.\n10. Oleoylethanolamide exerts anti-inflammatory effects on LPS-induced THP-1 cells by enhancing PPARα signaling and inhibiting the NF-κB and ERK1/2/AP-1/STAT3 pathways Yang, Lichao | Guo, Han | Li, Ying | Meng, Xianglan | Yan, Lu | Dan Zhang, | Wu, Sangang | Zhou, Hao | Peng, Lu | Xie, Qiang | Jin, Xin\n11. Analysis of clinicopathological characteristics associated with the outcome of oral squamous cell carcinoma and the establishment of tissue microarrays Jin, Xin | Liu, Dongjuan | Zhao, Xin | Zhou, Yu | Jiang, Lu | Li, Jing | Zeng, Xin | Chen, Qianming\nOncology Letters 2016;12(5):3175-3182.\nThe aim of this study was to evaluate clinicopathological risk factors associated with the fatal outcome of oral squamous cell carcinoma (OSCC) in a large cohort of Chinese patients, and to construct tissue microarrays (TMAs) using this cohort. Univariate and multiple logistic regression analyses were performed to evaluate the predictors of poor prognosis in a cohort of 232 patients with OSCC, after which the patient tumor tissues were used to construct TMAs. Univariate logistic regression analysis indicated that a poor outcome of OSCC was associated with the male gender, a history of smoking, the tumor-node-metastasis stage and lymph node metastasis. Multiple logistic regression analysis demonstrated that an increased risk of mortality in patients with OSCC was significantly and independently associated with lymph node metastasis (odds ratio, 3.421; 95% confidence interval, 1.609–7.273). Therefore, the results of the present study suggested that lymph node metastasis is an independent risk factor associated with a poor prognosis of OSCC patients. TMAs of OSCC were successfully constructed, and are the first TMAs to be reported in mainland Chinese patients.\noral squamous cell carcinoma; cohort study; tissue microarrays; lymph node metastasis\n12. Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone Cui, Zhuang | Crane, Janet | Xie, Hui | Jin, Xin | Zhen, Gehua | Li, Changjun | Xie, Liang | Wang, Long | Bian, Qin | Qiu, Tao | Wan, Mei | Xie, Min | Ding, Sheng | Yu, Bin | Cao, Xu\nAnnals of the Rheumatic Diseases 2015;75(9):1714-1721.\nOsteoarthritis; Arthritis; Treatment\n13. High HIV incidence epidemic among men who have sex with men in china: results from a multi-site cross-sectional study Xu, Jun-Jie | Tang, Wei-Ming | Zou, Hua-Chun | Mahapatra, Tanmay | Hu, Qing-Hai | Fu, Geng-Feng | Wang, Zhe | Lu, Lin | Zhuang, Ming-Hua | Chen, Xi | Fu, Ji-Hua | Yu, Yan-Qiu | Lu, Jin-Xin | Jiang, Yong-Jun | Geng, Wen-Qing | Han, Xiao-Xu | Shang, Hong\nInfectious Diseases of Poverty 2016;5(1):82.\nRecent upsurge of new HIV infections among men who have sex with men (MSM) is a major concern in China. Paucity of national-level information regarding the burden and predictors of this progressive epidemic of new infections called for a multi-centric, timely and comprehensive investigation.\nMixed methods were used to recruit MSM from seven cities in China between 2012 and 2013. Recent and established HIV infections were estimated by Western Blot and BED HIV-1 capture enzyme immunoassay. Syphilis and herpes simplex virus-2 (HSV-2) were also tested.\nA total of 4496 eligible MSM were recruited. The majority was aged ≤35 years (77.5 %), migrants (60.3 %), never married (69.8 %), and played receptive role in anal sex (70.5 %). The HIV prevalence was 9.9 %, and 41.9 % were recently infected, with sensitivity/specificity adjusted HIV incidence of 8.9 (95 % CI: 7.6-10.2)/100 Person-Years. The prevalence of history HSV-2 and syphilis were 12.5 % and 8.5 %, respectively. Recent HIV infection was associated with having multiple male partners (aOR = 1.4, 95 % CI 1.1-1.9), recreational drug use (aOR = 2.2, 95 % CI 1.6-3.0), anal bleeding (aOR = 2.1, 95 % CI 1.4-3.0), syphilis infection (aOR = 2.8, 95 % CI 1.9-4.3) and history HSV-2 infection (aOR = 2.3, 95 % CI 1.5-3.3).\nHigh rate of recent HIV infection is potentially resulting in progressive deterioration of the overall HIV epidemic among MSM in China. Targeted interventions to address high-risk MSM including those having multiple partners, history of recreational drug use and syphilis or HSV-2 infection seemed to be the need of the hour.\nThe online version of this article (doi:10.1186/s40249-016-0178-x) contains supplementary material, which is available to authorized users.\nMen who have sex with men (MSM); HIV; Incidence; BED HIV-1 capture enzyme immunoassay (BED-CEIA)\n14. Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis Li, Ling | Qu, Ye | Jin, Xin | Guo, Xiao Qin | Wang, Yue | Qi, Lin | Yang, Jing | Zhang, Peng | Li, Ling Zhi\nScientific Reports 2016;6:32131.\n15. Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer’s disease model Xu, Jiqing | de Winter, Fred | Farrokhi, Catherine | Rockenstein, Edward | Mante, Michael | Adame, Anthony | Cook, Jonathan | Jin, Xin | Masliah, Eliezer | Lee, Kuo-Fen\nScientific Reports 2016;6:31692.\n16. Genome-wide characteristics of de novo mutations in autism Yuen, Ryan K C | Merico, Daniele | Cao, Hongzhi | Pellecchia, Giovanna | Alipanahi, Babak | Thiruvahindrapuram, Bhooma | Tong, Xin | Sun, Yuhui | Cao, Dandan | Zhang, Tao | Wu, Xueli | Jin, Xin | Zhou, Ze | Liu, Xiaomin | Nalpathamkalam, Thomas | Walker, Susan | Howe, Jennifer L. | Wang, Zhuozhi | MacDonald, Jeffrey R. | Chan, Ada | D’Abate, Lia | Deneault, Eric | Siu, Michelle T. | Tammimies, Kristiina | Uddin, Mohammed | Zarrei, Mehdi | Wang, Mingbang | Li, Yingrui | Wang, Jun | Wang, Jian | Yang, Huanming | Bookman, Matt | Bingham, Jonathan | Gross, Samuel S. | Loy, Dion | Pletcher, Mathew | Marshall, Christian R. | Anagnostou, Evdokia | Zwaigenbaum, Lonnie | Weksberg, Rosanna | Fernandez, Bridget A | Roberts, Wendy | Szatmari, Peter | Glazer, David | Frey, Brendan J. | Ring, Robert H. | Xu, Xun | Scherer, Stephen W.\n17. Primitive neuroectodermal tumor originating from the lung: A case report Jin, Xin | Cao, Jianfeng | Liu, Yong | Bian, Fang | Zhao, Qingqing | Wang, Yan | Lv, Xu | Huang, Yayong\nOncology Letters 2016;12(4):2692-2695.\nprimitive neuroectodermal tumor; lung; diagnosis; treatment\n18. Shaping Action Sequences in Basal Ganglia Circuits Jin, Xin | Costa, Rui M\nCurrent opinion in neurobiology 2015;33:188-196.\nMany behaviors necessary for organism survival are learned anew and become organized as complex sequences of actions. Recent studies suggest that cortico-basal ganglia circuits are important for chunking isolated movements into precise and robust action sequences that permit the achievement of particular goals. During sequence learning many neurons in the basal ganglia develop sequence-related activity - related to the initiation, execution, and termination of sequences - suggesting that action sequences are processed as action units. Corticostriatal plasticity is critical for the crystallization of action sequences, and for the development of sequence-related neural activity. Furthermore, this sequence-related activity is differentially expressed in direct and indirect basal ganglia pathways. These findings have implications for understanding the symptoms associated with movement and psychiatric disorders.\n20. The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis Ben-David, Uri | Ha, Gavin | Khadka, Prasidda | Jin, Xin | Wong, Bang | Franke, Lude | Golub, Todd R.\nNature Communications 2016;7:12160.\n21. Characteristics and Distribution of Phosphorus in Surface Sediments of Limnetic Ecosystem in Eastern China Zhang, Wenqiang | Jin, Xin | Zhu, Xiaolei | Shan, Baoqing\nPLoS ONE 2016;11(6):e0156488.\nPhosphorus (P) is an essential nutrient for aquatic organisms; however, excessive P inflow to limnetic ecosystems can induce eutrophication. P concentrations in the rivers, wetlands and lakes of Eastern China have been amplified by fertilizer and sewage inputs associated with the development of industry and agriculture. Yet, knowledge of the distribution and speciation of P is lacking at the regional scale. We determined the distribution and speciation of P in limnetic ecosystems in Eastern China using Standards, Measurements and Testing (SMT) and phosphorus nuclear magnetic resonance (31P-NMR). The results indicate that P pollution in surface sediments was serious. Inorganic P (Pi) was the primary drive of variation in total P (TP) among different river systems, and Pi accounted for 71% to 90% of TP in surface sediment in Eastern China. Also, the concentrations of TP and Pi varied among watersheds and Pi primarily drove the variation in TP in different watersheds. Sediments less than 10-cm deep served as the main P reservoir. Environmental factors affect the speciation and origin of P. NaOH-Pi, HCl-Pi and organic P (Po) were related to pH accordingly at the regional scale. The physicochemical properties of sediments from different limnetic ecosystems affect the P speciation. HCl-Pi was higher in wetland sediments than in riverine and lake sediments in Eastern China. Conversely, NaOH-Pi was lowest in wetland sediments. Total Po concentration was lower in riverine sediments than in other sediments, but Mono-P was higher, with an average concentration of 48 mg kg−1. Diesters-P was highest in lake sediments. By revealing the regional distribution of TP, Pi and Po, this study will support eutrophication management in Eastern China.\n22. Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese Li, Yuanfeng | Si, Lanlan | Zhai, Yun | Hu, Yanling | Hu, Zhibin | Bei, Jin-Xin | Xie, Bobo | Ren, Qian | Cao, Pengbo | Yang, Fei | Song, Qingfeng | Bao, Zhiyu | Zhang, Haitao | Han, Yuqing | Wang, Zhifu | Chen, Xi | Xia, Xia | Yan, Hongbo | Wang, Rui | Zhang, Ying | Gao, Chengming | Meng, Jinfeng | Tu, Xinyi | Liang, Xinqiang | Cui, Ying | Liu, Ying | Wu, Xiaopan | Li, Zhuo | Wang, Huifen | Li, Zhaoxia | Hu, Bo | He, Minghui | Gao, Zhibo | Xu, Xiaobing | Ji, Hongzan | Yu, Chaohui | Sun, Yi | Xing, Baocai | Yang, Xiaobo | Zhang, Haiying | Tan, Aihua | Wu, Chunlei | Jia, Weihua | Li, Shengping | Zeng, Yi-Xin | Shen, Hongbing | He, Fuchu | Mo, Zengnan | Zhang, Hongxing | Zhou, Gangqiao\nNature Communications 2016;7:11664.\nThis genome-wide association study on persistent hepatitis B virus (HBV) infection among Chinese confirms previously associated genetic loci while discovering a novel protective locus at 8p21.3. The study also demonstrates the nearby gene INST10 suppresses HBV replication in vitro.\n23. Induction chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in stage III-IVb nasopharyngeal carcinoma patients with Epstein-Barr virus DNA ≥4000 copies/ml: a matched study Guo, Shan-Shan | Tang, Lin-Quan | Chen, Qiu-Yan | Zhang, Lu | Liu, Li-Ting | Guo, Ling | Mo, Hao-Yuan | Luo, Dong-Hua | Huang, Pei-Yu | Xiang, Yan-Qun | Sun, Rui | Chen, Ming-Yuan | Wang, Lin | Lv, Xing | Zhao, Chong | Guo, Xiang | Cao, Ka-Jia | Qian, Chao-Nan | Zeng, Mu-Shen | Bei, Jin-Xin | Hong, Ming-Huang | Shao, Jian-Yong | Sun, Ying | Ma, Jun | Mai, Hai-Qiang\nA total of 325 high-risk NPC patients treated with IC+CCRT or CCRT alone who were treated with intensity-modulated radiation therapy (IMRT) between March 2007 and March 2013 were included. For each patient in the IC+CCRT group, a matched pair in the CCRT group was matching for: gender, age, T stage, N stage, clinical stage and WHO (World Health Organization) type. The primary endpoint was overall survival (OS), and the secondary endpoints were progression-free survival (PFS), distant metastasis-free survival (DMFS), and locoregional relapse-free survival (LRFS).\nThere were no significant differences in OS, PFS, DMFS, and LRFS between the IC+CCRT (148 patients) and CCRT (177 patients) groups. After matching, 103 paired patients were analyzed, and there were no differences between the IC+CCRT and CCRT groups regarding clinical outcomes. Based on the subgroup analysis of 156 very-high-risk patients (stage N2-3 with EBV DNA ≥4000 copies/ml), the 5-year OS of the IC+CCRT and CCRT groups was 84.3% and 67.5% (P =0.033), respectively. Based on our multivariate analysis, the treatment group was significantly associated with OS (P=0.034; HR0.451, 95%CI 0.216-0.941).\nIC+CCRT did not improve the clinical outcomes of high-risk NPC patients compared to CCRT alone. However, in very-high-risk patients, IC+CCRT treatment led to increased OS compared to patients received CCRT treatment alone.\nnasopharyngeal carcinoma; induction chemotherapy; concurrent chemotherapy; IMRT; EBV DNA\n24. Environmentally Relevant Dose of Bisphenol A Does Not Affect Lipid Metabolism and Has No Synergetic or Antagonistic Effects on Genistein’s Beneficial Roles on Lipid Metabolism Ding, Shibin | Zuo, Xuezhi | Fan, Ying | Li, Hongyu | Zhao, Nana | Yang, Huiqin | Ye, Xiaolei | He, Dongliang | Yang, Hui | Jin, Xin | Tian, Chong | Ying, Chenjiang\nPLoS ONE 2016;11(5):e0155352.\nBoth bisphenol A (BPA, an endocrine disrupting chemicals) and genistein (a phytoestrogen mainly derived from leguminosae) are able to bind to estrogen receptors, but they are considered to have different effects on metabolic syndrome, surprisingly. We here investigate the effects of an environmentally relevant dose of BPA alone and the combined effects with genistein on lipid metabolism in rats. Eight groups of adult male Wistar rats, fed with either standard chow diet or high-fat diet, were treated with BPA (50μg/kg/day), genistein (10mg/kg/day), and BPA plus genistein for 35 weeks, respectively. Metabolic parameters in serum and liver were determined; the hematoxylin/eosin and oil Red O staining were used to observe liver histologically; gene expressions related to hepatic lipid metabolism were analyzed by Real-time PCR; protein expressions of PPARγ, PPARα and LC3 in liver were analyzed by western blotting. No difference of body weight gain, total energy intake, liver weight/body weight or body fat percentage in both STD- and HFD-fed sub-groups was observed after treatment with BPA, genistein, or BPA plus genistein (P>0.05). Genistein alleviated lipid metabolism disorder and decreased the mRNA and protein expression of PPARγ (P<0.05), and increased the protein expression of LC3II (P<0.05) in liver of HFD-fed rats. However, BPA treatment had no effect on lipid metabolism in rats alone (P>0.05) or combined with genistein. Our findings suggest that long-term environmentally relevant dose of BPA did not affect lipid metabolism, and had no synergetic or antagonistic roles on genistein’s beneficial function on hepatic lipid metabolism.\n25. Synthesis of 7-Aminocoumarin by Buchwald–Hartwig Cross Coupling for Specific Protein Labeling in Living Cells Jin, Xin | Uttamapinant, Chayasith | Ting, Alice Y.\nChembiochem : a European journal of chemical biology 2011;12(1):65-70.\nPRIME time: We report the synthesis of a pH-insensitive blue fluorophore, 7-aminocoumarin, by using palladium-catalyzed Buchwald–Hartwig cross coupling. 7-Aminocoumarin can be used to tag recombinant proteins on the cell surface and inside living cells through PRIME (probe incorporation mediated by enzymes), and unlike 7-hydroxycoumarin, can be visualized in acidic organelles such as endosomes.\ncell imaging; cross-coupling; enzyme engineering; fluorescent probes; palladium


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url: =Research Progress of Biodiesel Preparation--《Chemical Industry and Engineering Progress》2003年01期\n《Chemical Industry and Engineering Progress》 2003-01\nWang Yiping,Zhai Yi,Zhang Jinli,Li Wei,Han Zhenting (School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072)\nThis paper presents the research and development of biodiesel preparation by direct use and blending process,microemulsions process,thermal cracking process and transesterification process.Some suggestions for further research of biodiesel are also provided.\n5 Chen Ying,Lin Jinqing(College of Materials Science and Engineering,Huaqiao University,Quanzhou,Fujian,362021);The Research Progress of the Catalysts Which Use Transesterification Reaction to Prepare Biodiesel[J];Chemical Engineering & Equipment;2010-08\n6 CHEN Lin,CHEN Kai,DENG Bing-qing,LI Zhen(Department of Engineering Mechanics,Key Laboratory for Thermal Science and Power Engineering of Ministry of Education,Tsinghua University,Beijing 100084,China);Experimental Investigation of Metallic Corrosion in Bio-fuels[J];Corrosion & Protection;2009-03\n7 WU Xiang-Hong ZHENG Dan-Xing HE Xin-Ju JING Shu-Hong (Beijing University of Chemical Technology,Beijing 100029,China);THE SPECIFIC HEAT CAPACITY MEASUREMENT OF COLZA OIL AND BIODIESEL BY MICROCALORIMETER[J];Journal of Engineering Thermophysics;2007-05\n10 ZHANG Ling-jun,ZHANG Wei-xing (College of Materials Science and Chemical Engineering,Zhejiang University,Hangzhou 310027,China);Study on Preparation of Biodiesel from Cotton Oil[J];Technology & Development of Chemical Industry;2008-11\n3 LIU Shou chang GUAN Xin xin HAN Jia xian (School of Chemistry and Chemical Ingineering,Zhengzhou Univ.,Zhengzhou,Henan,450052);Study on Homogeneous Catalysis for Preparation of Fatty Acid Esters Through Transesterication[J];China Surfactant Detergent & Cosmetics;1999-05\n4 SONG Cheng-cai1,2,QI Yong-qin1,HOU Xiang-lin1(1.Institute of Coal Chemistry,Chinese Academy of Sciences,Taiyuan 030001,China;2.Graduate University of Chinese Academy of Sciences,Beijing 100039,China);Study of fatty acid esterification under subcritical condition[J];China Surfactant Detergent & Cosmetics;2008-04\n5 JIANG Yingxiang,LIU Shujuan,CAI Yingying,ZHANG Qianqian,LIU Yanbing (Faculty of Environmental Science and Engineering,Kunming University of Science and Technology,Kunming 650093);Preparation of Biodiesel from Refined Palm Oil[J];Materials Review;2011-S1\n7 ZHONG Cai-wang CHEN Yi-zhen (Department of Chemical Engineering and R&D Center for Membrane Technology, Chungyuan Christian University, Chungli Taoyuan, Taiwan 32023);Biodiesel Technology and Its Potential to Develop in Indonesia[J];Journal of Dongguan University of Technology;2006-04\n9 Chen Ying,Lin Jinqing(College of Materials Science and Engineering,Huaqiao University,Quanzhou,Fujian,362021);The Research Progress of the Catalysts Which Use Transesterification Reaction to Prepare Biodiesel[J];Chemical Engineering & Equipment;2010-08\n10 Wang Senlin (Fujian College of Forestry ) Feng Guanyin ( Henan Teachers' University ) Hang Began ( Beijing University );Studies on the Transesterification and Kinetics of Rapeseed Oil(RSO) with Methal(MeOH)[J];Journal of Fujian College of Forestry;1992-02\n4 Hui Sun, Jin-Zhao Duan, Qi-Lin Wang, Yu-Qi Ding, Hui Lou*, Xiao-Ming Zheng Institute of Catalysis, Zhejiang University, Hangzhou 310028;Biodiesel production from transesterification by using KF/Sm_2O_3 as a catalyst[A];[C];2008\n6 Li Yuzhu,Yu Haiye (College of Biological & Agricultural Engineering, Jilin University , Changchun 130025);Review on the research and application of biodiesel oil[A];[C];2006\n7 Li Yuzhu,Yu Haiy (College of Biological & Agricultural Engineering, Jilin University, Changchun 130025);A comprehensive comparison of bio-oil and bio-diesel[A];[C];2006\n4 YAO Xiao-jun (Ma'anshan Waste Water Treatment Plant No. Two,Ma'anshan 243000,China);Synthesis of Glycerol Triacetate Catalyzed by Solid Superacid[J];Anhui Chemical Industry;2007-03\n5 HE Hong-bo,YAO Ri-sheng,JIANG Lai-en(School of Chemical Engineering,Hefei University of Technology,Hefei 230009,China);Research Progress of Biodiesel Preparation[J];Anhui Chemical Industry;2008-06\n6 SU Min-guang1,YU Shao-ming1,WU Ke2,YU Zhi-min2,YANG Yan-hong1(1.School of Chemical Engineering,Hefei University of Technology,Hefei 230009,China;2.The Engineering Technology Research Center for Municipal Solid Waste and Resource Application of Anhui province,Hefei University,Hefei 230022,China);Study on the Conditions of Swill Oil Produced Biodiesel by Enzymatic[J];Anhui Chemical Industry;2009-06\n7 Zong Wei1 Dong Hai-li2(1 School of Food and Biological Engineering,Zhengzhou University of Light Industry,Henan,Zhengzhou 450002;2 Departmen of Chemistry Engineering,Huainan Union University,Huainanu,232001);The Applications of Lipases in Food Industry[J];Anhui Agricultural Science Bulletin;2007-15\n10 MENG Chun-xiao et al(College of Life Science,Shandong University of Technology,Zibo,Shandong 255049);Study on Developing Biomass Energy by Microalgae[J];Journal of Anhui Agricultural Sciences;2007-31\n3 WANG Po,WANG Xiang-yang(Anhui Design Institute of Chemical Industry,Hefei 230009,China);Preparation of Biodiesel from Waste Cooking Oil and Ethanol[J];Anhui Chemical Industry;2011-02\n5 Zha Guojun Zhang Shimin Zhang Wudi Yin Fang (Provincial Key Laboratory of Rural Energy Engineering,Yunnan Normal University,Kunming 650092,PRC);Preparation of Biodiesel Fuel with Tea Seed Oil[J];Anhui Agricultural Science Bulletin;2007-17\n8 WU Dong-hui et al(School of Chemistry and Chemical Engineering,Nantong University,Nantong,Jiangsu 226007);Preparation of Bio-diesel from Transesterification of Soybean Oil Catalyzed by KOH/Al_2O_3[J];Journal of Anhui Agricultural Sciences;2009-04\n9 CAI Xin-an(Department of Biologic and Chemical Engineering,Jingdezhen Comprehensive College,Jingdezhen,Jiangxi 333000);Preparing Biodiesel from Waste Grease Restaurant by Two-step Catalyzed Process by Potassium Bisulfate and Sodium Hydroxide[J];Journal of Anhui Agricultural Sciences;2009-14\n6 ZHOU Xing,CHEN Ligong,LI Xinliang,YANG Xin (Department of Oil Application & Management Engineering,Logistical Engineering University,Chongqing 401311,China);APPLICATION OF IONIC LIQUID[SO_3H-Bmim][HSO_4]IN SYNTHESIS OF BIODIESEL FROM WASTE EDIBLE OIL WITH HIGH ACID NUMBER[A];[C];2010\n7 ;Study on biodiesel production by the transesterification reaction of Tung oil[A];[C];2008\n10 SHAO Ping, JIANG Shaotong, YING Yanjie (School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230009, China;2 Faculty of Electronic and Information, Zhejiang Wanli University, Ningbo 315100, China);Simulation and analysis of the influences of feed concentration and rate on molecular distillation[A];[C];2006