Aside from all the sources that may already corroborate that Prison Break has reached its ending in totality, e.g., IMDB/Wikipedia, it seems exceedingly unlikely that we would see Michael Scofield in action again, as the final episode of Prison break tells us: Michael hears of the bounty and devises plans for Sara's escape.
In the end, knowing that he is dying from a brain tumor, Michael sacrifices himself for his brother, wife and child.
- Wikipedia
We don't see him die, but we do see Sara and his child at his gravestone, assuredly marking his demise.
When we also consider all the other loose ends tied up (other prisoners dying, Lincoln's absolution, deconstruction of 'The Company'), it lends for little further possible plot to continue on.
Update :
Prison break going to be revived
One of these unanswered questions that likely immediately jumps to mind is: [
SPOILER ALERT] how in the world is Michael still alive?
For those that don’t know, “Prison Break” ended with a made for TV movie in which the character sacrifices himself in order to save Lincoln, Sarah (Sara Tancredi) and her unborn child.
According to Deadline, the 10-episode event series revival will mostly ignore the events of this finale, but will provide a “logical explanation” as to why the character is alive.
However, even if they explain how he survived his death, writers also need to explain how he survived his terminal brain tumor.
movies.stackexchange.com/users/1125/hexparrot
No.
The the show is over and there are no plans for a season 5.
movies.stackexchange.com/users/4128/Colin D
"Prison Break", a television series on the Fox Network, ended its run in 2009, after 4 seasons.
It concerned the breakout of a group of felons from a prison in Chicago, and the ensuing run to evade capture by the FBI and international agents.
It starred: Wentworth Miller, who has gone on to other roles, though, decidedly few; Dominic Purcell who played his incarcerated brother, who has moved into motion pictures in a number of action thrillers, and guest television spots; Robert Knepper, who had a number of television projects since Prison Break, also a number of films; William Fichtner, who played the FBI agent in pursuit, has a currently-active television series "Crossing Lines", and a number of film roles since.
Long story short, I don't think the show "Prison Break" is on anyone's radar for a comeback.
UPDATE:
Today, 2015/01/18, it was revealed
that : ...
“There is some speculation in the press about Prison Break, which honestly was slightly news to us….
Although we’ve made it clear over the years to the studio that we would bring Prison Break back in a heartbeat...
It’s probably the perfect event series.
If our old partners in that show are interested, that would be great.
But at the moment, we have nothing else to report.”
Purcell and Miller are currently recurring in their roles as villains Heat Wave and Captain Cold on The Flash on The CW.
That series was renewed for a second season earlier this week.
movies.stackexchange.com/users/304/wbogacz
Submitting this as a NEW answer, since it clearly contradicts the first, based on information just received - after an additional 2 years.
According to information released August 6, 2015, Prison Break will be back for a season of 10 further episodes.
From PopSugar :
Cochairman Dana Walden added that the reboot will be "a bit of a sequel" that picks up with the characters several years after the events of the final season of the show.
"It will address some questions that were set up at the end of the series," she said, and though she didn't confirm who besides Purcell and Miller would be back, she teased that "some of the iconic characters from that show will be back."
Though there's no word on when it will come back, we do know the return is slated to be a 10-episode arc.
movies.stackexchange.com/users/304/wbogacz
Season 5 is scheduled to air on Tuesdays, starting April 4 this year.
Source
movies.stackexchange.com/users/19472/CinCout
I am a big fan of "Prison Break" and want Michael Scofield in action again. So please can anybody tell me, will I be able to see  the gang  again in action or not? Are there any plans for Season 5?
Will there be any more seasons of "Prison Break"?
movies.stackexchange.com
<prison-break>
movies.stackexchange.com/questions/13954
movies.stackexchange.com/users/6168/Neelesh Pandey
Acoording to information released on August 6th, 2015, Prison Break will be back for another season. Cochairman Dana Walden teased that '' some of the iconic charecters from that show will be back.''. Prison Break will return for a season of 10 further episodes.
Prison Break will return for a season of 10 further episodes. Cochairman calls reboot "a bit of a sequel" "Some of the iconic characters from that show will be back. "It will address some questions that were set up at the end of the series" 