ABSTRACTIn Part 1 (this issue), I deconstructed IPE, past and present, to reveal the Eurocentric foundations of the discipline. This second part completes my critical historiography by revealing how Open Economy Politics, which dominates the latest phase of American IPE, is Eurocentric. However, some readers will, quite rightly, want to know why Eurocentrism poses a problem for IPE and what an alternative non-Eurocentric approach might look like. Accordingly, this article lays out some of the basic properties of what I call ‘inter-civilizational political economy’. To this end, deconstructing OEP is undertaken in tandem with reconstructing a non-Eurocentric inter-civilizational account of trade regime change in the last few centuries. From there, I proceed to specify some key empirical areas that an inter-civilizational research agenda would examine, focussing on three types of politico-economic systems change: the rise of capitalism, the rise and development of globalization, and changes in the distribut...