An MTA that covers the entire commuting area can co-ordinate among jurisdictions at all territorial levels and reduce negative consequences of urban sprawl. Fatal crashes between road users remain a common occurrence on city streets, whilst they have almost been eliminated in rail or air transport. A growing number of local governments are embracing Vision Zero: a vision of no one being killed or seriously injured in urban traffic to rectify this. In support of such ambitious targets, this report investigates key road safety questions in the context of selected cities in Europe and beyond.