The industry added USD 44 billion to the US GDP in 2015 and paid USD 10 billion in taxes (RFA, 2016). One strategy to ultimately reach the Renewable Fuels Standard (RFS) targets is to make stepwise improvements in the existing biorefinery concepts. These stepwise improvements must include a regional strategy that builds in enough flexibility to use the “cheapest sources of renewable carbon” within a given region. Such flexibility implies, for example, using grain sorghum, switchgrass, or miscanthus in the US Midwest, sweet sorghum or cane sugar in the US South, guayule bagasse in the US Southwest, almond hull sugars in California and even citrus peel waste in Florida.